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Roche Molecular Systems Inc
Roche Molecular Systems Inc_20100107
Roche Molecular Systems Inc_20100128

Roche Molecular Systems Inc patents


Recent patent applications related to Roche Molecular Systems Inc. Roche Molecular Systems Inc is listed as an Agent/Assignee. Note: Roche Molecular Systems Inc may have other listings under different names/spellings. We're not affiliated with Roche Molecular Systems Inc, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "R" | Roche Molecular Systems Inc-related inventors


 new patent  Dna polymerases with increased 3'-mismatch discrimination

Disclosed are mutant DNA polymerases having increased 3′-mismatch discrimination relative to a corresponding, unmodified polymerase. The mutant polymerases are useful in a variety of disclosed primer extension methods. Also disclosed are related compositions, including recombinant nucleic acids, vectors, and host cells, which are useful, e.g., for production of the mutant... Roche Molecular Systems Inc

 new patent  Plate with wells for chemical or biological reactions, and multiple imaging of such a plate by means of an imaging system

The present disclosure provides a plate comprising an array of wells for chemical or biological reactions, wherein each of the wells comprises a reaction chamber with at least one opening on a surface of the plate. The array of wells consist of a plurality of adjacent blocks of wells, wherein... Roche Molecular Systems Inc

Helper oligonucleotide for improved efficiency of amplification and detection/quantitation of nucleic acids

Improved methods for the detection and quantitation of a target nucleic acid in a sample using a non-extending helper oligonucleotide are described. The methods include contacting nucleic acids in a sample with amplification reagents including one or more primers, one or more non-extending helper oligonucleotides, and one or more probes.... Roche Molecular Systems Inc

Dna polymerases with increased 3'-mismatch discrimination

Disclosed are mutant DNA polymerases having increased 3′-mismatch discrimination relative to a corresponding, unmodified polymerase. The mutant polymerases are useful in a variety of disclosed primer extension methods. Also disclosed are related compositions, including recombinant nucleic acids, vectors, and host cells, which are useful, e.g., for production of the mutant... Roche Molecular Systems Inc

Dna polymerases with improved activity

Disclosed are DNA polymerases having increased reverse transcriptase efficiency relative to a corresponding, unmodified polymerase. The polymerases are useful in a variety of disclosed primer extension methods. Also disclosed are related compositions, including recombinant nucleic acids, vectors, and host cells, which are useful, e.g., for production of the DNA polymerases.... Roche Molecular Systems Inc

Dna polymerases with improved activity

Provided are DNA polymerases having increased reverse transcriptase efficiency relative to a corresponding, unmodified polymerase. The polymerases are useful in a variety of primer extension methods. Also provided are related compositions, including recombinant nucleic acids, vectors, and host cells, which are useful, e.g., for production of the DNA polymerases.... Roche Molecular Systems Inc

System for separating and detecting an analyte

The present invention relates to an automated analytical system and an automated method for separating and detecting an analyte, as well as an automated analytical instrument.... Roche Molecular Systems Inc

Dna polymerases and related methods

Disclosed are mutant DNA polymerases having improved extension rates relative to a corresponding, unmodified polymerase. The mutant polymerases are useful in a variety of disclosed primer extension methods. Also disclosed are related compositions, including recombinant nucleic acids, vectors, and host cells, which are useful, e.g., for production of the mutant... Roche Molecular Systems Inc

Internal control probes for improving pcr assay performance

The present invention relates to methods for improving multiplex real-time PCR assays by the use of an internal control probe labeled with Quasar 705.... Roche Molecular Systems Inc

Compositions and methods for detection of hepatitis c virus genotype 3

Methods for the rapid detection of the presence or absence of Hepatitis C Virus (HCV) in a biological or non-biological sample are described. The methods can include performing an amplifying step, a hybridizing step, and a detecting step. Furthermore, primers and probes targeting HCV and kits are provided that are... Roche Molecular Systems Inc

Compositions and methods for detection of mycoplasma genitalium

Methods for the rapid detection of the presence or absence of Mycoplasma genitalium (MG) in a biological or non-biological sample are described. The methods can include performing an amplifying step, a hybridizing step, and a detecting step. Furthermore, primers, probes targeting the target MG gene, along with kits are provided... Roche Molecular Systems Inc

Compositions and methods for detection of trichomonas vaginalis

Methods for the rapid detection of the presence or absence of Trichomonas vaginalis (TV) in a biological or non-biological sample are described. The methods can include performing an amplifying step, a hybridizing step, and a detecting step. Furthermore, primers, probes targeting the target TV gene, along with kits are provided... Roche Molecular Systems Inc

Cell surface marker depletion in a sample processing device

The disclosure provides methods, devices, and kits for conducting a quantitative analysis of a whole blood sample. Various modifications to the disclosed methods, devices, and kits are described.... Roche Molecular Systems Inc

Rfid detection systems and methods

Improved detection and tracking methods and systems are disclosed herein. The use of RFID labels that are operably connected upon complex formation in a binding assay is described as well as the use of RFID labels and supplemental identifiers to enhance component tracking in assay systems.... Roche Molecular Systems Inc

Rfid tracking systems and methods

Improved component tracking methods and systems are disclosed herein. The use of suspended reagent and/or sample identifiers are described as well as the use of suspended and supplemental identifiers to enhance component tracking in assay systems.... Roche Molecular Systems Inc

Protein-based sample collection matrices and devices

Provided herein are methods and compositions to effectively isolate nucleic acids using protein-based sample collection matrices.... Roche Molecular Systems Inc

Detection of met exon 14 deletions and associated therapies

Provided herein are methods and compositions to detect MET exon 14 skipping using RT-PCR, and methods of treating individuals with MET exon 14 deleted cancers.... Roche Molecular Systems Inc

Methods and compositions for classifying dlbcl

Provided herein are methods and compositions to classify DLBCL subtypes using quantitative RT-PCR.... Roche Molecular Systems Inc

Solid waste bag unit and analyzer comprising solid waste bag unit

A solid waste bag unit for solid waste of an analyzer is disclosed. The solid waste bag unit comprises a bag, and an insert, wherein the insert is arranged within the bag. Further, an analyzer and a method for removing solid waste of an analyzer are disclosed.... Roche Molecular Systems Inc

Analyzer & loading a rack into a rack slot of an analyzer

An analyzer is disclosed. The analyzer comprises a rack slot configured to receive at least one rack, wherein the rack slot comprises a front end, at which the rack is manually loadable into the rack slot, and a rear end, which is opposite to the front end and at which... Roche Molecular Systems Inc

System and nucleic acids containing fluid processing

A system and method for the processing of nucleic acids containing fluids involving manipulation of magnetically responsive particles contained therein are disclosed. In the system, a holder holds a plurality of containers containing the fluids, a heating device applies thermal energy to the fluids for incubation, and a separating device... Roche Molecular Systems Inc

Qualitative and quantitative detection of microbial nucleic acids

The present invention relates to new methods and uses for the qualitative and quantitative detection of microbial nucleic acids using at least a first control nucleic acid, or a first and a second control nucleic acid in different concentrations. The method is based on amplification of nucleic acids, for example... Roche Molecular Systems Inc

Sample processing methods

A method of processing a sample may include introducing a sample into a vessel, the vessel having proximal and distal ends, the sample being introduced into the proximal end of the vessel; incubating the sample in the vessel with a substance capable of specific binding to a preselected component of... Roche Molecular Systems Inc

Use of rnase h for the selective amplification of viral dna

The present invention concerns the amplification of at least a first and a second target nucleic acid that may be present in at least one fluid sample using RNase H and a polymerase with reverse transcriptase activity.... Roche Molecular Systems Inc

Suspension container for binding particles for the isolation of biological material

A device, method and system is provided for binding particles for the separation and/or isolation of biological materials. In particular, a container is provided including a suspension of binding particles for the isolation of biological material, inner walls forming an elongate groove at the bottom of said container, and a... Roche Molecular Systems Inc

Hev assay

A method of simultaneously amplifying genotypes 1, 2, 3 and/or 4 of HEV is disclosed comprising amplifying the genotypes 1, 2, 3 and/or 4 of HEV with one single none-degenerate forward primer partially overlapping the 5′UTR region of HEV and at least one reverse primer. Also disclosed are related methods... Roche Molecular Systems Inc

Compositions and methods for detection of zika virus

Methods for the rapid detection of the presence or absence of Zika virus in a biological or non-biological sample are described. The methods can include performing an amplifying step, a hybridizing step, and a detecting step. Furthermore, primers and probes targeting Zika virus arid kits are provided that are designed... Roche Molecular Systems Inc

Device for separation

A device comprising a support part is disclosed. The support part is configured to receive a tip holder, a liquid waste container and a multiwell plate. The multiwell plate comprises at least one row of vessels which comprise a closed bottom and an open top. A method of removing liquid... Roche Molecular Systems Inc

Optics for analysis of microwells

In one aspect of the present disclosure an optical measurement device includes a sample holder defining a sample plane, wherein the sample holder is configured to arrange a sample carrier including an array of measurement positions in the sample plane, an illumination unit configured to illuminate the sample plane, a... Roche Molecular Systems Inc

Methods and compositions for nucleic acid detection

Methods, compositions, reaction mixtures, kits, and/or systems for producing a complementary sequence to a region in a target polynucleotide in a sample are provided. In some aspects, the methods, compositions, reaction mixtures, kits, and/or systems comprise subjecting the sample to a nucleic acid amplification reaction in a reaction mixture under... Roche Molecular Systems Inc

Method for teaching positioning of a bar code scanner & processing a sample or reagent

A method for teaching positioning of a bar code scanner is disclosed. The method includes moving the bar code scanner relative to a first bar code so as to sweep a light beam emitted from the bar code scanner across the first bar code, detecting an orientation of the bar... Roche Molecular Systems Inc

Molded flow channel

A nanopore based sequencing system includes a plurality of nanopore sensors. Each nanopore sensor has a portion for receiving a fluid. The nanopore based sequencing system includes a fluid chamber configured to guide the fluid over the plurality of nanopore sensors and an inlet configured to deliver the fluid into... Roche Molecular Systems Inc

Use of titanium nitride as a counter electrode

A nanopore cell includes a titanium nitride (TiN) counter electrode configured to be at a first electric potential. The nanopore cell also include a working electrode configured to be at a second electric potential and an insulating wall. The insulating wall and the working electrode form at least a portion... Roche Molecular Systems Inc

Multiplexed nucleic acid target identification by strucutre based probe cleavage

The present invention provides for novel methods and compositions for nucleic acid sequence detection. Unique, identifying cleavage fragments from probes, bound to target nucleic acids, are produced during PCR by the 5′-nuclease activity of the polymerase. The identity of the targets can be determined by identifying the unique cleavage fragments.... Roche Molecular Systems Inc

Pipetting device for an processing a sample or reagent, processing a sample or reagent & pipetting a sample or reagent

A pipetting device (100) for an apparatus for processing a sample or reagent is disclosed. The pipetting device (100) comprises a coupling mechanism, wherein the coupling mechanism comprises at least a first coupling unit (104) adapted to be coupled to a first pipetting tip (108) and a second coupling unit... Roche Molecular Systems Inc

07/06/17 / #20170191044

Dna polymerases with improved activity

Disclosed are DNA polymerases having increased reverse transcriptase efficiency, mismatch tolerance, extension rate and/or tolerance of RT and polymerase inhibitors relative to a corresponding, unmodified polymerase. The polymerases are useful in a variety of disclosed primer extension methods. Also disclosed are related compositions, including recombinant nucleic acids, vectors, and host... Roche Molecular Systems Inc

07/06/17 / #20170191053

Successive capture of nucleic acid by magnetic glass particles

Provided herein are methods and components for successive capture of nucleic acids using magnetic glass particles.... Roche Molecular Systems Inc

07/06/17 / #20170191111

Detecting an analyte in a flash and glow reaction

Accurate measurements of the presence or absence of an analyte (e.g., MRSA) in a sample are provided. For example, the sample can be subjected to an activation reagent (potentially after an initial reagent has already been added), which can cause a flash signal that increases and then decreases over time.... Roche Molecular Systems Inc

06/29/17 / #20170183720

Generic the stabilization of specific rna

The present invention relates to methods and compositions for the stabilization of specific RNA molecules that can either be the target for detection or the control standard.... Roche Molecular Systems Inc

06/15/17 / #20170166953

Methods and kits for joining fragmented nucleic acids together

Methods and kits for joining fragmented nucleic acid sequences together are provided, including performing an amplifying step including contacting a sample suspected of including a fragmented target nucleic acid with a pair of external primers and a pair of self-complementary internal primers, and generating a full length target nucleic acid.... Roche Molecular Systems Inc

05/11/17 / #20170131317

Method for prevention of contamination

A method is provided for disposing of a liquid within an automated analytical system for processing a fluid biological sample, wherein a contamination prevention shield including channels for pipets or pipet tips is reversibly docked to a container for liquid waste in order to reduce the risk of cross-contamination. A... Roche Molecular Systems Inc

04/13/17 / #20170100715

Instrument and the automated thermal treatment of liquid samples

An instrument and a method for the automated thermal treatment of liquid samples are disclosed. An inter-distance between a temperature-controlled receptacle for loading with a plurality of vessels for containing the samples and end portions of optical fibers can be varied, wherein the receptacle is configured to form a thermal... Roche Molecular Systems Inc

04/13/17 / #20170101632

Dna polymerases with improved activity

Disclosed are DNA polymerases having increased reverse transcriptase efficiency relative to a corresponding, unmodified polymerase. The polymerases are useful in a variety of disclosed primer extension methods. Also disclosed are related compositions, including recombinant nucleic acids, vectors, and host cells, which are useful, e.g., for production of the DNA polymerases.... Roche Molecular Systems Inc

04/06/17 / #20170096634

Mycobacteria pre-analytic reagent

A pre-analytic reagent is provided for liquefaction of a sputum sample and complete inactivation of one or more Mycobacteria, e.g., Mycobacterium tuberculosis (MTB) suspected of being contained in the sputum sample at room temperature. The pre-analytic reagent may include one or more of each of: a chaotropic agent, a chelator,... Roche Molecular Systems Inc

03/30/17 / #20170088907

Dual probe assay for the detection of hcv

The invention further provides reaction mixtures and kits for amplifying and detecting a target nucleic acid of HCV involving the use of at least two detectable probes specific for different sequence portions of an amplicon.... Roche Molecular Systems Inc

03/16/17 / #20170076046

Informatics platform for integrated clinical care

An informatics platform provides an architecture to integrate information from relevant patient information systems. The informatics platform may include: a workflow tool that can be used to prepare and review information at multi-disciplinary board meetings; a visual timeline of patient events; a search engine to search for patients with specific... Roche Molecular Systems Inc

03/09/17 / #20170067114

Novel mutation in the epidermal growth factor receptor kinase domain

A new in-frame deletion was found in exon 19 of the EGFR gene, the exon that is often mutated in tumors. The invention comprises methods of detecting the mutation, methods of prognosis and methods of predicting response to treatment based on the presence of absence of the mutation.... Roche Molecular Systems Inc

03/09/17 / #20170067122

Diagnostic test for susceptibility to b-raf kinase inhibitors

The present invention provides methods and reagents for the detection of a mutation in BRAF and methods of selecting patients for treatment if a B-Raf kinase inhibitor, such as a selective B-Raf kinase inhibitor.... Roche Molecular Systems Inc

02/09/17 / #20170037452

Compositions and methods for detection of mycobacterium tuberculosis

Method for the rapid detection of the presence or absence of Mycobacterium tuberculosis (MTB) and other members of the MTB-complex in a biological or non-biological sample are described. The methods can include performing an amplifying step, a hybridizing step, and a detecting step. Furthermore, primers, probes targeting the esxJ gene,... Roche Molecular Systems Inc

02/02/17 / #20170029791

Dna polymerases with improved activity

Disclosed are DNA polymerases having increased reverse transcriptase efficiency relative to a corresponding, unmodified polymerase. The polymerases are useful in a variety of disclosed primer extension methods. Also disclosed are related compositions, including recombinant nucleic acids, vectors, and host cells, which are useful, e.g., for production of the DNA polymerases.... Roche Molecular Systems Inc

02/02/17 / #20170029792

Dna polymerases with improved activity

Disclosed are DNA polymerases having increased reverse transcriptase efficiency relative to a corresponding, unmodified polymerase. The polymerases are useful in a variety of disclosed primer extension methods. Also disclosed are related compositions, including recombinant nucleic acids, vectors, and host cells, which are useful, e.g., for production of the DNA polymerases.... Roche Molecular Systems Inc

01/26/17 / #20170023567

Identification of antigen epitopes and immune sequences recognizing the antigens

Methods, compositions, and reaction mixtures are provided for identifying a T cell receptor (TCR) and an epitope peptide that specifically binds the TCR. Methods, compositions, and reaction mixtures are also provided for identifying a plurality of T cell receptors and corresponding epitope peptides that specifically bind the T cell receptors.... Roche Molecular Systems Inc








ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009



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