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Salk Institute For Biological Studies
Salk Institute For Biological Studies 027731
Salk Institute For Biological Studies The Universitat Bern
Salk Institute For Biological Studies The Intellectual Property And Technology Transfer

Salk Institute For Biological Studies patents


Recent patent applications related to Salk Institute For Biological Studies. Salk Institute For Biological Studies is listed as an Agent/Assignee. Note: Salk Institute For Biological Studies may have other listings under different names/spellings. We're not affiliated with Salk Institute For Biological Studies, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "S" | Salk Institute For Biological Studies-related inventors


Reprogramming progenitor compositions and methods of use therefore

The invention generally features compositions comprising induced pluripotent stem cell progenitors (also termed reprogramming progenitor cells) and methods of isolating such cells. The invention also provides compositions comprising induced pluripotent stem cells (iPSCs) derived from such progenitor cells. Induced pluripotent stem cell progenitors generate iPSCs at high efficiency. In particular... Salk Institute For Biological Studies

Methods for treating metabolic disorders using fgf

The method provides methods and compositions for treating metabolic disorders such as impaired glucose tolerance, elevated blood glucose, insulin resistance, dyslipidemia, obesity, and fatty liver.... Salk Institute For Biological Studies

Err alpha and err gamma are essential coordinators of cardiac metabolism and function

Provided herein are methods and kits for increasing cardiac contraction, increasing mitochondrial activity, and/or increasing oxphos activity. Such methods include use of therapeutically effective amounts of one or more agents that increases estrogen-related receptor (ERR) α activity and one or more agents that increases ERRγ activity. In some examples, the... Salk Institute For Biological Studies

Intestinal fxr agonism enhances glp-1 signaling to restore pancreatic beta cell functions

Disclosed are embodiments of a method of treating or preventing latent autoimmune diabetes of adults (LADA) in a subject. Such embodiments include administering to a subject (e.g., via the gastrointestinal tract) a therapeutically effective amount of one or farnesoid X receptor (FXR) agonist compounds, thereby activating FXR receptors in the... Salk Institute For Biological Studies

Fibroblast growth factor (fgf) 1 with mutation in the heparin binding domain and methods of use to reduce blood glucose

The present disclosure provides FGF1 mutant proteins having one or more mutations in the heparin binding domain. Such mutants may also have an N-terminal deletion, point mutation(s), or combinations thereof. In some examples, the mutant FGF1 proteins have reduced mitogenic activity. Also provided are nucleic acid molecules that encode such... Salk Institute For Biological Studies

Methods of using fibroblast growth factor (fgf) 1 with mutation in the heparin binding domain and methods to reduce blood glucose

The present disclosure provides FGF1 mutant proteins having one or more mutations in the heparin binding domain. Such mutants may also have an N-terminal deletion, point mutation(s), or combinations thereof. In some examples, the mutant FGF1 proteins have reduced mitogenic activity. Also provided are nucleic acid molecules that encode such... Salk Institute For Biological Studies

Novel ulk1 inhibitors and methods using same

In certain aspects, the invention provides a method for treating a disease or condition in a subject, the method comprising co-administering to a subject in need thereof a therapeutically effective amount of at least one ULK1-inhibiting pyrimidine, and a therapeutically effective amount of an mTOR inhibitor.... Salk Institute For Biological Studies

Ppar agonists, compounds, pharmaceutical compositions, and methods of use thereof

Provided herein are compounds of formula (I) useful for the treatment of PPAR-delta related diseases (e.g. mitochondrial diseases, muscular diseases, vascular diseases, demyelinating diseases and metabolic diseases).... Salk Institute For Biological Studies

Ppar agonists, compounds, pharmaceutical compositions, and methods of use thereof

Provided herein are compounds of Formula (I) and compositions useful in increasing PPARS activity. The compounds and compositions provided herein are useful for the treatment of PPARS related diseases (e.g., muscular diseases, vascular disease, demyelinating disease, and metabolic diseases).... Salk Institute For Biological Studies

Fgf2 truncations and mutants and uses thereof

The present disclosure provides FGF2 mutant proteins, such as those having an N-terminal deletion, point mutation(s), or combinations thereof, which can reduce blood glucose in a mammal. Thus, the disclosed mutant FGF2 proteins can be used to treat one or more metabolic diseases. In some examples, mutant FGF2 proteins have... Salk Institute For Biological Studies

Mammalian chimeric complementation

Disclosed herein are chimeric mammals, such as a chimeric mammal comprising cells derived from at least a first mammal and a second mammal, wherein the cells from the first mammal comprise a genetic modification at one or more loci and the cells from the second mammal form at least one... Salk Institute For Biological Studies

Generation and use of polyclonal and monoclonal antibodies specific for 3-phosphohistidine

Isolated monoclonal antibodies and or antigen binding fragments thereof are disclosed herein that specifically bind polypeptides comprising a histidine phosphorylated at N3 (3-pHis). Nucleic acids encoding these antibodies, vectors including these nucleic acids, and host cells transformed with these vectors and nucleic acids are also disclosed. Methods are also disclosed... Salk Institute For Biological Studies

Oncolytic tumor viruses and methods of use

Recombinant adenoviruses that selectively replicate in E2F deregulated tumor cells are described. The recombinant adenoviruses have a genome encoding a modified E1A protein, a modified or deleted E4orf1 protein, a modified or deleted E4orf6/7 protein, or any combination thereof, such that the recombinant adenoviruses exhibit replication defects in normal cells... Salk Institute For Biological Studies

Systems and methods for culturing nephron progenitor cells

Provided herein are self-renewable nephron progenitor cell (srNPC) and methods for making and using.... Salk Institute For Biological Studies

Use of inhibitor of apoptosis protein (iap) antagonists in hiv therapy

Provided herein is the use of compounds that modulate the activity of inhibitor of apoptosis proteins (1APs), alone or in combination with other therapeutic agents, in the treatment of human immunodeficiency virus (HIV). Described herein is the use of IAP antagonists in the treatment of human immunodeficiency virus (HIV) in... Salk Institute For Biological Studies

Modulation of estrogen receptor-related receptor gamma (err gamma) and uses therefor

This application provides methods of increasing vascularization, muscle performance, muscle rehabilitation, and/or mitochondrial activity in subjects in need thereof, by administering a therapeutically effective amount of one or more agents that increases ERRγ activity to the subject. Such agents can include one or more ERRγ agonists. In some examples the... Salk Institute For Biological Studies

Cdk modulators and methods for the treatment of cancer

Disclosed is a polypeptide that includes amino acids 183-222 of CRIF, wherein the polypeptide does not include the full length CRIF1 amino acid sequence. Also disclosed is a nucleic acid molecule encoding this polypeptide, vectors including this nucleic acid molecule, and host cells transformed with these vectors. In some embodiments,... Salk Institute For Biological Studies

Regulating the interaction between tam ligands and lipid membranes with exposed phosphatidyl serine

The present disclosure provides methods for modulating the interaction between a TAM ligand and a lipid membrane containing phosphatidyl serine (PtdSer). In one example, such methods use a TAM receptor agonist having a PtdSer-containing lipid bilayer membrane with Gas6 and/or Protein S bound to the membrane to activate signaling from... Salk Institute For Biological Studies

Compositions and methods for treating type 1 and type 2 diabetes and related disorders

The invention features compositions comprising in vitro generated beta cells capable of glucose-stimulated insulin secretion, methods of inducing beta cell maturation from embryonic or induced pluripotent stem cell-derived beta-like cells, and methods of using in vitro generated beta cells for the treatment of type 1 diabetes, type 2 diabetes, or... Salk Institute For Biological Studies

Polyketide synthase variants and uses thereof

The present invention relates to methods for producing polyketide synthase variants, and for altering the activity and/or substrate specificity of putative native and variant polyketide synthases. The present invention further relates to compositions comprising said polyketide synthase variants, compounds prepared using said polyketide synthase variants, and uses of said polyketide... Salk Institute For Biological Studies

Analogs of fexaramine and methods of making and using

embodiments of a method of making the same, and of a composition comprising them are disclosed herein. Also disclosed are embodiments of a method of treating or preventing a metabolic disorder in a subject, comprising administering to a subject (e.g., via the gastrointestinal tract) a therapeutically effective amount of one... Salk Institute For Biological Studies

Methods for treating metabolic disorders using fgf

The method provides methods and compositions for treating metabolic disorders such as impaired glucose tolerance, elevated blood glucose, insulin resistance, dyslipidemia, obesity, and fatty liver.... Salk Institute For Biological Studies

Compositions and methods for treating metabolic disorders

The disclosure features compositions and methods for treating a metabolic disorder, including diabetes, conditions associated with inhibition of insulin secretion, or for increasing longevity. In some embodiments, the methods comprise administering an anti-CGRP antagonist antibody.... Salk Institute For Biological Studies








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