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Sanofi aventis Deutschland Gmbh
Sanofi
Sanofi aventis
Sanofi Pasteur
Sanofi Sa
Sanofi Pasteur Sa
Sanofi Pasteur Biologics Llc
Sanofi Pasteur Limited
Sanofi Pasteur Biologics Co
Sanofi Pasteur Inc
Sanofi aventis U s Llc
Sanofi Biotechnology
Sanofi Pasteur Vaxdesign Corporation
Sanofii aventis Deutschland Gmbh
Sanofi Pasteur Ltd
Sanofi aventis Deutschland
Sanofi aventis Detuschland Gmbh
Sanofi Pasteur Vaxdesign Corp
Sanofi Pasteur Limited sanofi Pasteur Limitee
Sanofi Pasteur S a
Sanofi avents Deutschland Gmbh
Sanofi aventid Deutschland Gmbh
Sanofi avenits Deutschland Gmbh
Sanofiaventis Deutschland Gmbh
Sanofi avetnis Deutschland Gmbh

Sanofi patents


Recent patent applications related to Sanofi. Sanofi is listed as an Agent/Assignee. Note: Sanofi may have other listings under different names/spellings. We're not affiliated with Sanofi, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "S" | Sanofi-related inventors


 new patent  Sanofi Aventis Deutschland Gmbh

. . ... Sanofi

 new patent  Insulin glargine/lixisenatide fixed ratio formulation

The present invention refers to a pharmaceutical composition comprising (a) lixisenatide or/and a pharmaceutically acceptable salt thereof, and (b) insulin glargine or/and a pharmaceutically acceptable salt thereof, wherein the compound (b) and compound (a) are present in a fixed ratio.. . ... Sanofi

Ca6 antigen-specific cytotoxic conjugate and methods of using the same

Cytotoxic conjugates comprising a cell binding agent and a cytotoxic agent, therapeutic compositions comprising the conjugate, methods for using the conjugates in the inhibition of cell growth and the treatment of disease, and a kit comprising the cytotoxic conjugate are disclosed are all embodiments of the invention. In particular, the cell binding agent is a monoclonal antibody, and epitope-binding fragments thereof, that recognizes and binds the ca6 glycotope. ... Sanofi

Anti-chikv antibodies and uses thereof

The present invention concerns antibodies and antigen-binding fragments of antibodies which specifically bind to and neutralize chikungunya virus (chikv) and which are engineered to develop therapeutics in order to treat chikv disease or prevent chikv infection. The invention also relates to pharmaceutical compositions comprising antibodies of the invention and the use of the antibodies for the prevention and treatment of chikv disease.. ... Sanofi

Drug delivery device and retaining member for a drug delivery device

A drug delivery device includes a housing, a mechanical assembly which is at least partially accommodated in the housing and a retaining member for retaining the mechanical assembly in the housing wherein the retaining member is engaged with the housing such that the device is configured to be damaged when the mechanical assembly or parts thereof are forcefully separated from the housing.. . ... Sanofi

Injection system

Described is a medicament cartridge comprising a housing having open proximal and distal ends, a first coupling mechanism, and a syringe slidably disposed in the housing. The syringe includes a needle and has a retracted position in which the needle is covered by the housing and an extended position in which the needle is exposed. ... Sanofi

Stabilized pharmaceutical formulations of insulin analogues and/or insulin derivatives

Stabilized pharmaceutical formulations of insulin analogues and/or insulin derivatives are disclosed.. . ... Sanofi

Neisseria meningitidis trypsin-like serine protease polypeptides and compositions thereof

The present invention relates to novel polypeptides derived from neisseria meningitidis proteins, in particular auto-transporters of the trypsin-like serine protease subclass, such as iga1p, app and ausi, and their use in immunogenic compositions i.a., vaccine compositions for the prevention and/or treatment of meningococcal infections. In particular, it provides fragments of iga1p, app and ausi and polypeptides comprising or consisting of these fragments and fusions thereof, which may be used in immunogenic compositions, for example vaccine compositions.. ... Sanofi

Meningitidis vaccines comprising subtilinases

The present invention relates to novel polypeptides derived from meningitis proteins, in particular auto-transporters of the subtilinase subclass, and their use in vaccines and vaccine compositions for the prevention and/or treatment of meningitis and meningococcal infections.. . ... Sanofi

Compositions comprising n. meningitidis proteins

The invention relates to immunogenic compositions comprising at least two neisseria meningitidis (nm) protein antigens selected from the group consisting of a trypsin-like serine protease auto-transporter antigen such as igai p, app or ausi antigen, a nalp antigen and a tbpb antigen. Preferably, the composition of the invention comprises (i) the trypsin-like serine protease auto-transporter antigen and (ii) the nalp antigen and/or tbpb antigen.. ... Sanofi

Stabilized pharmaceutical formulations of insulin analogues and/or insulin derivatives

Stabilized pharmaceutical formulations of insulin analogues and/or insulin derivatives are disclosed.. . ... Sanofi

Stabilized pharmaceutical formulations of insulin aspart

Stabilized pharmaceutical formulations of insulin aspart are disclosed.. . ... Sanofi

Stabilized pharmaceutical formulations of insulin analogues and/or insulin derivatives

Stabilized pharmaceutical formulations of insulin analogues and/or insulin derivatives are disclosed.. . ... Sanofi

Icp0-mediated enhanced expression system

Methods and compositions for increasing the production of recombinant proteins by introducing icp0 to cells capable of producing a recombinant protein are encompassed. In one method, the recombinant protein is a protein that is required for the replication of a replication defective virus, wherein the recombinant protein is provided to the replication defective virus in trans.. ... Sanofi

05/03/18 / #20180117244

Flexible container for an injection device

The present disclosure relates to a flexible container for an injection device including a flexible bag having an interior volume to be filled with a liquid medicament, an outlet located at a first end of the bag, and a contraction member connected to the bag to displace a second end of the bag located opposite to the first end towards the first end.. . ... Sanofi

04/19/18 / #the present disclosure relates to an injection device for dispensing of a liquid medicament, the device comprising:
04/12/18 / #20180100019

Humanized anti-cxcr5 antibodies, derivatives thereof and their use

The present invention relates to humanized antibodies that specifically bind to cxcr5 and can, for example, inhibit cxcr5 function. The invention also includes uses of the antibodies to treat or prevent cxcr5 related diseases or disorders.. ... Sanofi

04/12/18 / #20180099097

Drug delivery device with tamper-evident closure

The present invention relates to a drug delivery device for dispensing of a dose of a medicament, comprising a housing to accommodate a cartridge being at least partially filled with a medicament, wherein the housing comprises a dispensing end with an access opening which is closed by a tamper-evident closure.. . ... Sanofi

04/12/18 / #20180099084

Device and method for determining information related to a medical device

The invention relates to an apparatus (2, 3), comprising a mating unit (20-1, 20-2) for releasably attaching the apparatus (2) to a medical device (1) or for releasably receiving at least a part of the medical device (1). The apparatus (2, 3) further comprises one or more optical sensors (25, 26) and/or one or more acoustical sensors (27) for determining information related to a condition and/or use of the medical device (1). ... Sanofi

04/05/18 / #20180093046

Autoinjector with an inner plunger which disengages the outer plunger to retract the syringe carrier

Described is an autoinjector comprising a case, a chassis slidably arranged in the case, a syringe carrier operably coupled to the chassis, an outer plunger selectively engaged to the chassis, an inner plunger selectively engaged to the outer plunger, and a drive spring applying a biasing force to the outer plunger. The biasing force is applied to the inner plunger when the inner plunger is engaged to the outer plunger. ... Sanofi

04/05/18 / #20180093042

Sensor and sensor assembly for capacitive determination of a filling level

The present disclosure relates to a sensor for a capacitive determination of a filling level of a cartridge filled with a liquid substance. The sensor comprises a planar flexible foil arrangeable to an outer circumference of a tubular shaped barrel of the cartridge. ... Sanofi

04/05/18 / #20180092965

Treatment type 2 diabetes mellitus patients

A pharmaceutical combination for use in glycemic control in a type 2 diabetes mellitus patient, said combination comprising (i) lixisenatide or/and a pharmaceutically acceptable salt thereof, (ii) insulin glargine or/and a pharmaceutically acceptable salt thereof, and (iii) optionally metformin or/and a pharmaceutically acceptable salt thereof.. . ... Sanofi

03/29/18 / #20180086799

Novel proteins specific for pyoverdine and pyochelin

The present disclosure provides hngal muteins that bind a pyoverdine family member or pyochelin and can be used in various application including pharmaceutical applications, for example, to inhibit or reduce growth of p. Aeruginosa. ... Sanofi

03/29/18 / #20180085537

Drug delivery device and predetermined breaking member for a drug delivery device

A drug delivery device comprises a housing and a mechanical assembly, which is at least partially accommodated in the housing. The mechanical assembly comprises a predetermined breaking member, which is configured to be damaged when forcefully separated from the housing.. ... Sanofi

03/29/18 / #20180085528

Dosing mechanism and drug delivery device

This disclosure refers to a dosing mechanism for use in a drug delivery device implementing a dialing mode and a dispensing mode, wherein the dosing mechanism comprises a dose button, a housing and a determination unit. The dose button is activatable by the user for dose dispense, causing displacement of an indicating element connected to the housing from a first position to a second position. ... Sanofi

03/22/18 / #compounds of formula (i):

Sanofi

. . ... Sanofi

03/22/18 / #20180080592

Coded cartridge holder and fastener enabled by cartridge size

A coded cartridge holder for use with a drug delivery device is provided. The cartridge holder includes a fastener that becomes operative based in part on a length of a cartridge or a diameter of the cartridge. ... Sanofi

03/22/18 / #20180079119

Housing and drug delivery device herewith and method for producing a housing

The present disclosure is generally directed to a drug delivery device for selecting and dispensing a number of user variable doses of a medicament and to a housing for such a device. The housing comprises a twin-shot injection moulded casing with at least one window and at least one interface for engaging a further component part of the drug delivery device. ... Sanofi

03/22/18 / #20180078717

Medical device and method for limiting the use of the medical device

A method and system for detecting a limit of use of a medical device is disclosed. The method includes starting a timer of a medical device when said medical device is used for the first time, detecting the limit of use of the medical device and indicating the limit of use of the medical device. ... Sanofi

03/22/18 / #20180078603

Methods for treating severe atopic dermatitis by administering an il-4r inhibitor

The present invention provides methods for treating moderate-to-severe or severe atopic dermatitis (ad). The methods of the present invention comprise administering to a subject in need thereof one or more doses of an interleukin-4 receptor (il-4r) inhibitor such as an anti-il-4r antibody. ... Sanofi

03/22/18 / #20180078496

Article of manufacture comprising aflibercept or ziv-aflibercept

Article of manufacture comprising a packaging material, a polypeptide of seq id no:1, aflibercept or ziv-aflibercept or a biosimilar thereof, and a label comprising a printed statement which informs a prospective user of adverse events or adverse reactions.. . ... Sanofi

03/15/18 / #20180071460

Resettable drug delivery device

The present disclosure is generally directed to a resettable drug delivery device for selecting and dispensing a number of user variable doses of a medicament. The drug delivery device comprises a housing, a cartridge holder releasably attached to the distal end of the housing, a piston rod engaging a housing insert and a drive member, a dose setting member guided within the housing to allow rotation of the dose setting member during dose setting and dose dispensing, a clutch for rotationally coupling the drive member and the dose setting member, and a locking element which is rotationally constrained to the housing and is axially movable relative to the housing between a proximal dose setting position and a distal resetting position.. ... Sanofi

03/08/18 / #the present disclosure relates to a cartridge holder of an injection device, the cartridge holder comprising a tubular shaped elongated sleeve extending in an axial direction to accommodate a cartridge filled with a medicament, wherein the sleeve (29) comprises:
03/08/18 / #the present disclosure relates an elongated housing for an injection device for delivery of a liquid medicament, the housing comprising:
03/08/18 / #20180064884

Sealed needle assembly for medicament delivery device

The disclosure relates to a needle assembly adapted to couple with a medicament delivery device including a needle having a proximal tip and a distal tip, a needle hub coupled to the needle, a body adapted to engage the needle hub, a removable needle cap adapted to cover the distal tip, and a removable sealing element. The sealing element is adapted to seal an open proximal end of a compartment of the body, including the proximal tip, in such a manner that the proximal tip is housed in a sealed environment before use of the needle. ... Sanofi

03/01/18 / #20180057597

Anti-cd3 antibodies, anti-cd123 antibodies and bispecific antibodies specifically binding to cd3 and/or cd123

The present invention concerns antibody-like binding protein specifically binding to cd3 and binding specifically to at least one further antigen, for example cd123. The present invention also concerns antibody-like binding protein specifically binding to cd123 and binding specifically to at least one further antigen. ... Sanofi

03/01/18 / #20180057567

Multispecific antibodies facilitating selective light chain pairing

Provided herein are multispecific antibodies, e.g. Bispecific antibodies, which are modified such that the desired chain pairing takes place and/or can be selected for. ... Sanofi

03/01/18 / #20180057539

Multimerization of recombinant protein by fusion to a sequence from lamprey

The present invention relates to polymerized recombinant proteins, to recombinant nucleic acids coding for the polymerized recombinant proteins, to expression cassettes comprising the recombinant nucleic acids, to host cells transformed by the expression cassettes and to a method for multimerizing a recombinant protein. The polymerized proteins of the invention may be used in pharmaceutical or immunogenic compositions. ... Sanofi

03/01/18 / #20180056008

Drug delivery device

A mechanism in the body is used to drive a piston rod and comprises means for guiding the movement of the piston rod relatively to the body while delivering the drug. Further means are provided for releasing the piston rod from the means for guiding the movement, thus enabling a reset of the piston rod to a start position, especially after the receptacle has been emptied and is to be refilled. ... Sanofi

03/01/18 / #20180055994

Method of priming a medical pump

A method of priming a medical pump is disclosed. The method includes providing a medical pump comprising a chamber, a first plunger element and, a second plunger element. ... Sanofi

02/22/18 / #20180050161

Drug delivery device

The disclosure is generally directed to a drug delivery device for selecting and dispensing a number of user variable doses of a medicament. The device comprises a housing having a proximal end and an opposite distal end, a dose setting member rotatable relative to the housing during dose setting and during dose dispensing, and an axially compressible torsion spring which is rotationally and axially constrained with a first end to the housing. ... Sanofi

02/22/18 / #20180050160

Drug delivery device

The disclosure refers to an injection device for automatic spring driven injection of a liquid drug by which doses of an individual size can be set by a user. The injection device comprises a housing defining an interior space and having a longitudinal window, a rotatable dose dial axially retained in relation to the housing, a rotatable scale drum carrying indicia for indicating the size of the set dose, wherein the scale drum is functionally coupled to the dose dial to rotate when the dose dial is rotated to set a dose, a sliding element provided with a sliding window, which sliding element is adapted to slide axially in relation to the housing during dose setting, and through which sliding window the indicia carried by the scale drum is visible. ... Sanofi

02/22/18 / #20180050155

Drug delivery device

The present disclosure is generally directed to a drug delivery device for selecting and dispensing a number of user variable doses of a medicament. The device comprises a housing and at least two separate component parts, wherein for example at least one of these component parts performs a movement relative to the housing during dose setting and for example at least one of these component parts performs a movement relative to the housing during dose dispensing, and wherein the relative movement of the at least two separate component parts with respect to each other during dose setting differs from the relative movement of the at least two separate component parts with respect to each other during dose dispensing. ... Sanofi

02/15/18 / #20180047392

Methods and systems for modifying operational data of an interaction process or of a process for determining an instruction

It is inter alia disclosed to perform at least one of operating an interaction process with a user of the medical apparatus and determining, based on a representation of at least one instruction given by the user, at least one instruction operable by the medical apparatus. Therein, the at least one of the operating and the determining at least partially depends on operational data. ... Sanofi

02/15/18 / #20180043104

Sensor arrangement for an injection device

The disclosure relates to a sensor arrangement for an injection device to determine an axial position of at least one device component of the injection device inside a housing of the injection device. The sensor arrangement includes an elongated member located inside the housing, extending in an axial direction and having at least a first section and a second section of different magnetization. ... Sanofi

02/08/18 / #the disclosure relates to a medicament delivery device, comprising:
02/08/18 / #20180037619

Novel proteins specific for pyoverdine and pyochelin

The present disclosure provides hngal muteins that bind a pyoverdine family member or pyochelin and can be used in various application including pharmaceutical applications, for example, to inhibit or reduce growth of p. Aeruginosa. ... Sanofi

02/08/18 / #20180037618

Novel proteins specific for pyoverdine and pyochelin

The present disclosure provides hngal muteins that bind a pyoverdine family member or pyochelin and can be used in various application including pharmaceutical applications, for example, to inhibit or reduce growth of p. Acruginosa. ... Sanofi

02/08/18 / #20180036483

Drive mechanisms suitable for use in drug delivery devices

A drive mechanism suitable for use in drug delivery devices is disclosed. The drive mechanism may be used with injector-type drug delivery devices, such as those permitting a user to set the delivery dose. ... Sanofi

02/08/18 / #20180036411

Stable formulation of insulin glulisine

An aqueous pharmaceutical formulation comprising 200-1000 u/ml of insulin glulisine.. . ... Sanofi

02/08/18 / #20180036339

Meningococcal vaccine based on lipooligosaccharide (los) originating from modified neisseria meningitidis strains of immunotype l6

The invention especially relates to multivalent vaccine compositions that can treat or prevent at least 60, preferably 75% of infections caused by neisseria meningitidis especially of serogroup b. To this end, the invention in particular provides a lipooligosaccharide (lqs) of n. ... Sanofi

02/01/18 / #20180030156

Antibodies that bind il-4 and/or il-13 and their uses

The present invention relates to novel humanized anti-il-4 and il-13 antibodies and fragments thereof and novel bispecific antibodies and fragments thereof that specifically bind to il-4 and il-13. The invention also includes uses of the antibodies to treat or prevent il-4 and/or il-13 mediated diseases or disorders, including allergic asthma and dermatitis.. ... Sanofi

02/01/18 / #20180030101

Novel proteins specific for pyoverdine and pyochelin

The present disclosure provides hngal muteins that bind a pyoverdine family member or pyochelin and can be used in various application including pharmaceutical applications, for example, to inhibit or reduce growth of p. Aeruginosa. ... Sanofi

02/01/18 / #20180028760

Supplemental device for removable attachment to a medicament injection device

The disclosure provides a supplemental device configured for removable attachment to a medicament injection device. The supplemental device includes a display, a processor arrangement, at least one memory, and an image-capturing component. ... Sanofi

02/01/18 / #20180028759

Injection device with supplementary device

The present invention relates to a supplementary device for a manually operable injection device, the supplementary device comprising: a body (300) having at least one engaging member (340) to releasably mount the body (300) to the injection device (1) in a specific position (p) on an outside surface (106) of the injection device (1), at least one indicator (350; 370; 380) located on the body (300) and having a shape or contour to overlap or to align with a mark (150; 160; 170; 180) on the outside surface (106) of the injection device (1) when the body (300) is in or near the specific position (p).. . ... Sanofi

02/01/18 / #20180028757

Drive mechanism for an injection device

The present invention relates to a drive mechanism for an injection device for setting and dispensing of a dose of a medicament, the drive mechanism comprising:—a tubular shaped housing component (12, 45) extending in an axial direction (z) and comprising an inner thread (46),—a tubular shaped display member (80) having an outer thread (81) engaged with the inner thread (46), and—a dose member (90) axially displaceable between a dose setting position (s) and a dose dispensing position relative to the display member (80),—wherein the display member (80) comprises at least one blocking member (87) on its outer circumference to axially engage with a blocking structure (18) on an inside facing sidewall portion (12a) of the housing component (12, 45) to block an axial displacement of the dose member (90) from the dose setting position (s) towards the dose dispensing position.. . ... Sanofi

02/01/18 / #20180028637

Toxoid, compositions and related methods

The disclosure relates to generally to the field of toxin inactivation. More specifically, it relates to clostridial toxins, methods of inactivating these toxins and compositions (e.g., vaccines) comprising toxoids (e.g., produced by these methods). ... Sanofi

02/01/18 / #20180028400

Container for a liquid medicament

The present disclosure relates to a container for a liquid medicament that includes a wall structure with at least one flexible portion and confining an inner volume filled with the liquid medicament and an elongated extraction tube having at least a first portion and a second portion that are separated from each other along the tube and which are located inside the inner volume. The extraction tube is radially collapsible when exposed to a compressive force above a predefined threshold, and the first portion, which is located at a distal end of the extraction tube, is less resistive against radial collapsing than the second portion.. ... Sanofi

01/25/18 / #20180022817

Anti-ceacam5 antibodies and uses thereof

The present invention discloses antibodies which bind human and macaca fascicularis ceacam5 proteins, as well as isolated nucleic acids, vectors and host cells comprising a sequence encoding said antibodies. The invention also discloses immunoconjugates comprising said antibodies conjugated or linked to a growth-inhibitory agent, and to pharmaceutical compositions comprising antibodies, or immunoconjugates of the invention. ... Sanofi

01/25/18 / #20180022814

Specific anti-cd38 antibodies for treating human cancers

The present disclosure concerns an antibody that specifically binds cd38 which is capable of killing a cd38+ cell by induction of apoptosis, antibody-dependent cell-mediated cytotoxicity (adcc), and complement-dependent cytotoxicity. The disclosed antibody may be used as a medicament or in the making of a medicament, wherein the antibody is to be administered to a human subject in a safe therapeutic dose of about 20 mg/kg or below. ... Sanofi

01/25/18 / #20180022713

Heteroaryl compounds and uses thereof

The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.. . ... Sanofi

01/25/18 / #20180021520

Magnifying device for a medicament injection device

The present disclosure relates to a magnifying device attachable to an injection device. The magnifying device includes a frame having a distal end and having a proximal end opposite to the distal end and further has a receptacle extending from the distal end towards the proximal end. ... Sanofi

01/25/18 / #20180021518

Trigger mechanism and drug delivery device herewith

The present disclosure is generally directed to a trigger mechanism for initiating dispensing doses of a medicament from a drug delivery device. The trigger mechanism includes a trigger element movable in a first direction relative to a counter element. ... Sanofi

01/18/18 / #20180017531

Method and arrangement for acoustically testing the mechanical integrity of a cartridge

The present invention relates to a method of testing the mechanical integrity of a cartridge (10) containing a medicament and being arranged inside a drug delivery device (20). The invention also relates to a testing arrangement and to a respective drug delivery device, wherein the method comprises the steps of: acoustically stimulating the cartridge (10), measuring of the cartridge's (10) acoustic response (60) to the acoustic stimulation (32), comparing the acoustic response (60) with a standard response (62) of an intact cartridge (10), and determining the mechanical integrity of the cartridge (10) on the basis of the comparison.. ... Sanofi

01/11/18 / #20180008783

Assembly for a drug delivery device

An assembly for a drug delivery device is proposed, the assembly comprising: a housing; a clutch member; and a drive member, wherein one of the clutch member and the drive member is provided with at least one deflectable feature and the other one of the clutch member and the drive member is provided with at least one interaction feature, the clutch member and the drive member are movable relative to one another between a first relative position and a second relative position, in the first relative position, the clutch member and/or the drive member is rotatable relative to the housing, in the second relative position, the deflectable feature is arranged to prevent rotation of the clutch member and/or of the drive member relative to the housing, and wherein the deflectable feature and the interaction feature are arranged such that, when the clutch member and the drive member are moved relative to one another from the first relative position into the second relative position, the deflectable feature and the interaction feature mechanically interact in order to deflect the deflectable feature.. . ... Sanofi

01/11/18 / #20180008782

Method for assembling a drug delivery device and drug delivery device

A method for assembling a drug delivery device that includes mounting a cartridge with a bung, the mechanism, the plunger and the spring within a housing such that a spring biases a plunger in a dispensing direction and that a drum and/or the release member is attached to the plunger attaching a tool with torque measurement capability to the drum or a release member of a dose mechanism in a state where at least one housing part is detached from further housing part; setting a dose by rotating the dose setting member in a first direction, activating a trigger and monitoring the torque applied to the drum or the release member; releasing the trigger upon detection of a predetermined change in the torque measured by the tool; and releasing the tool and closing the housing.. . ... Sanofi

01/11/18 / #20180008781

Drug delivery device with a drive mechanism

The present disclosure relates to a drive mechanism which is suitable for an injection device, especially a drug delivery device. The mechanism comprises a housing having a longitudinal axis defined by a compartment for receiving a cartridge, a plunger suitable for acting on a bung of a cartridge retained in the housing, a strained pressure spring arranged between the housing and the plunger, a retaining member coupled to the plunger, and a release member operable between a first state, in which the release member constrains the retaining member to the housing, and a second state, in which the release member is movable relative to the housing.. ... Sanofi

01/11/18 / #20180008778

Data collection device for attachment to an injection device

A data collection device (20) for attachment to an injection device (1), such as an injector pen, comprises a sensor arrangement (26) to detect movement of a movable (70) of the injection device (1) relative to the data collection device (20) during delivery of a medicament by the injection device (1), and a processor arrangement (23) configured to, based on said detected movement, determine a medicament dosage administered by the injection device (1). The processor arrangement (23) may monitor the time that has elapsed since the medicament dosage was administered, and control a display (22) to show the medicament dosage (22a) and elapsed 22 time to provide a memory aid to the user. ... Sanofi

01/11/18 / #20180008707

Stable liquid formulation for monoclonal antibodies

The present invention concerns stable pharmaceutical compositions for monoclonal antibodies, for example igg antibodies. The invention further relates to medicaments and treatments using the pharmaceutical compositions of the invention. ... Sanofi

01/04/18 / #20180001027

Supplemental device for attachment to a pen injector and determination of a set dose amount using optical incremental encoder

A data collection device comprises at least two optical sensors configured to detect tick marks of a medicament dose indicator of the medicament delivery device in their respective detection areas, and a processing arrangement configured to determine a current medicament dosage programmed into said medicament delivery device based on a count of the tick marks that pass through the detection areas of the optical sensors during programming of said medicament dosage into said medicament delivery device. A direction of travel of the tick marks may be identified, to determine whether the programmed dosage is increasing or decreasing. ... Sanofi

01/04/18 / #20180001026

Auto-injector

An auto-injector for administering a dose of a liquid medicament (m) is presented having an elongate case arranged to be held by a user, a tubular chassis telescoped in the case and biased against the case so as to protrude from the case. The injector also includes a syringe with a hollow injection needle, a drive spring and a plunger for forwarding load of the drive spring to a stopper of the syringe. ... Sanofi

01/04/18 / #20180001019

Pre-filled drug cartridge with stopper partially protruding from it for facilitating priming

Disclosed is a combination of an infusion set consisting of infusion tubing and needle connected to a drug cartridge, the latter comprising a cylindrical body of inner diameter and having an open rear end, wherein a stopper is slidably disposed within the body. In an initial state after the cartridge has been filled, the stopper is partially disposed within the body such that the stopper protrudes from the rear end of the body by a distance. ... Sanofi

01/04/18 / #20180000920

Pharmaceutical compositions containing clostridium difficile toxoids a and b

This invention relates to compositions including clostridium difficile toxins and/or toxoids and corresponding methods. The compositions of the invention include one or more excipients that increase stability and/or decrease aggregation of the toxins.. ... Sanofi

01/04/18 / #20180000902

Prevention of hypoglycaemia in diabetes mellitus type 2 patients

A method for the prevention of hypoglycaemia in diabetes mellitus type 2 comprising administering (a) despro36exendin-4(1-39)-lys6-nh2 or/and a pharmaceutically acceptable salt thereof, and (b) a sulfonyl urea or/and a pharmaceutically acceptable salt thereof, to a subject in need thereof.. . ... Sanofi

12/28/17 / #the present invention relates to a monitoring device for monitoring operation of a drug delivery device and to a respective drug delivery device, wherein the monitoring device comprises:
12/28/17 / #20170369440

Process for the production of 2-[4-(cyclopropanecarbonyl)phenyl]-2-methyl-propanenitrile

A new process for the production of 2-[4-(cyclopropanecarbonyl)phenyl]-2-methyl-propanenitrile is described. This compound can be used for the production of drugs, such as fexofenadine.. ... Sanofi

12/28/17 / #20170368263

Sensor for use with a drug delivery device

An optical decoding system including an optical sensor integral with or attachable to a housing of a drug delivery device and configured to be directed at first and second rotatable components of a dose setting and dispensing mechanism of the drug delivery device and a processor configured to: (i) cause the optical sensor to capture images of the first and second rotatable components at least at the beginning and end of a medicament dose dispensing process; (ii) determine a rotational position of both the first and second rotatable components in each of the captured images; and (iii) determine from the rotational positions of the first and second rotatable components an amount of medicament delivered by the dose setting and dispensing mechanism of the drug delivery device.. . ... Sanofi

12/28/17 / #20170368256

Drug delivery device with electromagnetic drive unit

The disclosure relates to a drug delivery device having a drive unit includes a stator comprising a plurality of coils consecutively arranged in an axial direction, and an armature axially movable within the stator, the armature including a number of magnets and pole shoes consecutively arranged in the axial direction. A respective pole shoe is arranged between respectively neighbouring magnets. ... Sanofi

12/28/17 / #20170368164

Synergistic co-administration of computationally optimized broadly reactive antigens for h1n1 influenza

The present invention provides co-administration (for example, immunogenic cocktail compositions and/or prime-boost regimens) of computationally optimized h1n1 influenza hemagglutinin (ha) polypeptides. Co-administration of the optimized h1n1 influenza hemagglutinin (ha) polypeptides facilitates synergistic neutralization of viral infection and provides for improved protective immunity (e.g., a broad reactive immune response) to diverse and multiple h1n1 influenza virus strains, including both seasonal and pandemic strains.. ... Sanofi

12/21/17 / #20170361038

Assembly for a drug delivery device

The present disclosure concerns an assembly for a drug delivery device (1)comprising a housing (3), a first abutment surface (64), a second abutment surface (21), and a detachable member (7) which is detachable from the housing (3) and attachable to the housing (3), wherein the assembly is configured such that, during detachment of the detachable member (7) from the housing (3) for an nth time, n being a predetermined number, the first abutment surface (64) is brought into abutment with the second abutment surface (21), wherein the assembly is configured such that, when the first abutment surface (64) abuts with the second abutment surface (21), the detachable member (7) is enabled to be reattached to the housing (3) and, afterwards, the detachable member (7) is prevented from being detached from the housing (3).. . ... Sanofi

12/21/17 / #20170361035

Lock out member with different cross sections

An apparatus is presented comprising a lock out member configured to be implemented into a medical device, in particular a dispense interface, attachable to a second medical device, in particular a main body, wherein said lock out member is configured to prevent a second attachment of said medical device to said second medical device, wherein said lock out member has at least a first area with a first cross-sectional area, wherein said lock out member has at least a second area having a second cross-sectional area smaller than the first cross-sectional area, such that an electric resistance is defined between opposite ends of the lockout member and wherein said lock out member, at least in the second area, is made of a conductive material.. . ... Sanofi

12/21/17 / #20170360923

Novel immunogenic formulations comprising linear or branched polyacrylic acid polymer adjuvants

The present invention provides for novel immunological and vaccine formulations comprising a newly applied non-crosslinked polyacrylic acid polymer adjuvant. The adjuvants may be combined with a wide variety of immunogens to produce vaccines that are safe and effective when administered to a wide range of target animals. ... Sanofi

12/14/17 / #20170354784

Packaging for pre-filled drug cartridges with peg for pushing cartridge stopper for priming purposes

Disclosed is a packaging for a number of pre-filled drug cartridges comprising a body to which an infusion set with tubing and needle can be fitted, the body having an open rear end, wherein a stopper is slidably disposed within the body, wherein a peg is arranged on the packaging, the peg having a height which is such that when a cartridge is being put on the peg with the rear end and pushed against it until the rear end abuts a surface of the packaging, the stopper is moved within the body by such a distance that a predetermined volume of a medicament is displaced from the cartridge for priming the cartridge and infusion set.. . ... Sanofi

12/14/17 / #20170354570

Medicament delivery device

The disclosure relates to a medicament delivery device, comprising a medicament cartridge adapted to contain a medicament and a stopper slidably arranged within the cartridge. The stopper-comprises a rigid body that is enclosed partially by a soft sealing component.. ... Sanofi

12/07/17 / #20170348480

Needle interface

The invention relates to a needle interface (2) for connecting a hollow needle (3) having a proximal tip (3.1) to a medicament reservoir (1), the needle interface (2) comprising an inner ring (5) fixed to a reservoir wall (4) of the reservoir (1) and an outer ring (6) attachable to the needle (3), wherein one of the inner ring (5) and the outer ring (6) comprises at least one magnet (6.1) and wherein the other one of the inner ring (5) and the outer ring (6) comprises a magnetisable material (5.1) or a magnet (6.1).. . ... Sanofi

11/30/17 / #20170343550

Novel anti-cd38 antibodies for the treatment of cancer

Antibodies, humanized antibodies, resurfaced antibodies, antibody fragments, derivatized antibodies, and conjugates of same with cytotoxic agents, which specifically bind to cd38, are capable of killing cd3830 cells by apoptosis, antibody-dependent cell-mediated cytotoxicity (adcc), and/or complement-dependent cytotoxicity (cdc). Said antibodies and fragments thereof may be used in the treatment of tumors that express cd38 protein, such as multiple myeloma, chronic lymphocytic leukemia, chronic rnyelogenous leukemia, acute myelogenous leukemia, or acute lymphocytic leukemia, or the treatment of autoimmune and inflammatory diseases such as systemic lupus, rheumatoid arthritis, multiple sclerosis, erythematosus, and asthma. ... Sanofi

11/30/17 / #20170342389

Novel cytochrome p450 polypeptide with increased enzyme activity

The present invention pertains to an isolated p450 enzyme comprising or consisting of an amino acid sequence at least 80% identical to seq id no: 1, wherein said sequence comprises a threonine at position corresponding to position 225 and/or an aspartic acid mutation at position corresponding to position 289. The invention also concerns an isolated nucleic acid comprising a sequence encoding said enzyme, a vector comprising said nucleic acid, and a host cell containing said nucleic acid or said vector. ... Sanofi

11/30/17 / #20170340835

Drug delivery device with variable piston force

The present disclosure relates to a drug delivery device, comprising a housing, a cartridge, the cartridge containing a drug in a quantity sufficient for a plurality of doses of the drug, a bung, the bung being movably retained within the cartridge to dispense a dose of the drug from the cartridge upon movement of the bung with respect to the cartridge, and a drive mechanism, the drive mechanism being operable to transfer a driving force to the bung to dispense the dose of the drug from the cartridge. The drug delivery device is configured such that the maximal driving force which is transferrable to the bung via the drive mechanism varies and is adjusted to the current position of the bung within the cartridge.. ... Sanofi

11/30/17 / #20170340834

Drive mechanism and drug delivery device herewith

The present disclosure is generally directed to a drive mechanism for use in a drug delivery device having a cylindrical cartridge, i.e. A handheld injection device for selecting and dispensing a number of user variable doses of a medicament. ... Sanofi

11/30/17 / #20170340833

Drug delivery device comprising a prism

The present invention relates to a drug delivery device comprising a dose setting member (70) for setting user variable doses of a medicament and a display for indicating the dose set by the dose setting member (70). The display comprises a number wheel (100), which is rotationally coupled to the dose setting member (70) and is provided with a series of markings on its outer circumference, and at least one prism (90) deviating the image of the markings of the number wheel (100), e.g. ... Sanofi

11/30/17 / #20170340832

Pen-type injector

The present invention relates to injectors, such as pen-type injectors, that provide for administration of medicinal products from a multidose-cartridge and permit a user to set the delivery dose. The injector may include a housing, a piston rod adapted to operate through the housing, a dose dial sleeve located between the housing and the piston rod, and a drive sleeve located between the dose dial sleeve and the piston rod. ... Sanofi

11/30/17 / #20170340826

Pen-type drug injection device and optical dose value decoding system with additional sensor to distinguish between dose dialling and dose delivery mode

An optical decoding system comprising: a first optical sensor configured to be directed at a first rotatable component of a drug delivery device; a second optical sensor configured to be directed at a second rotatable component of a drug delivery device; and a processor configured to: receive signals from the first optical sensor, wherein the signals from the first optical sensor represent encoded dosage values present on the first rotatable component; receive signals from the second optical sensor, wherein the signals from the second optical sensor represent whether the second rotatable component is rotating or not; and to determine from the received signals whether the drug delivery device is in a drug dose dialling mode or a drug dose delivery mode.. . ... Sanofi

11/30/17 / #20170340806

Medical apparatus package

A package for components of a medical apparatus comprising a plurality of panels defining a container having an interior space. A first component of the medical apparatus is disposed within the interior space. ... Sanofi

11/30/17 / #20170340515

Pharmaceutical compositions comprising human antibodies to pcsk9

The present invention relates to pharmaceutical compositions comprising an antibody specifically binding to human proprotein convertase subtilisin/kexin type 9 (pcsk9), to methods for treating diseases or conditions in which proprotein convertase subtilisin/kexin type 9 (pcsk9) expression or activity causes an impact by administration of pcsk9-specific antibodies or antigen-binding fragments thereof and preferably by additional administration of an inhibitor of 3-hydroxy-3-methyl-glutaryl-coa reductase (hmg-coa reductase). The present invention further relates to pcsk9-specific antibodies or antigen-binding fragments thereof for use in the treatment of diseases or conditions in which pcsk9 expression or activity causes an impact. ... Sanofi

11/23/17 / #20170335292

Novel selection marker for cell transfection and protein production

The present invention is within the field of industrial protein production. The invention provides a novel expression system using dihydroorotate dehydrogenase (dhodh) as a selection marker in combination with leflunomide or a metabolite thereof, notably for use in mammalian cell lines. ... Sanofi

11/23/17 / #20170333557

Methods for treating atopic dermatitis by administering an il-4r antagonist

The present invention provides methods for treating atopic dermatitis (ad). Also provided are methods for improving one or more ad-associated parameter(s), and methods for decreasing the level of at least one ad-associated biomarker in a subject in need thereof. ... Sanofi

11/16/17 / #the present disclosure relates to an injection device for setting and dispensing of a dose of a medicament, the device comprising:

Sanofi

. . ... Sanofi

11/16/17 / #20170326304

Assembly for a drug delivery device and drug delivery device

An assembly for a drug delivery device is provided comprising a screw member comprising a thread, the thread including at least two consecutive portions, the portions having different leads. The device further includes a nut member. ... Sanofi

11/16/17 / #20170326301

Drug delivery device

A drug delivery device for selecting and dispensing a number of user variable doses of a medicament includes a housing having an opening, a dose selector operable to set a dose by rotation relative to the housing, a release member controlling movement of a piston in a dispensing direction, and a display comprising a units number wheel and a tens number wheel which are coupled to each other such that a continuous rotation of the units number wheel is translated into an intermittent rotary motion of the tens number wheel. The release member rotates, during dose dispensing, an angle corresponding to the dose set by the dose selector, thereby allowing a piston to move in a dispensing direction.. ... Sanofi

11/16/17 / #20170326299

Drive mechanism for a medication delivery device and medication delivery device

A drive mechanism for a medication delivery device is presented having a housing, a rotation member that rotates in a first direction with respect to the housing during setting of a dose of a medication and rotates in a second direction with respect to the housing during delivery of the dose, the second direction being opposite to the first direction. The device also has a piston rod that is displaced in a distal direction with respect to the housing for delivering the dose, a drive member which follows rotational movement of the rotation member in the second direction during delivery of the dose, and a stop member which prevents rotational movement of the drive member with respect to the housing in the first direction during setting of the dose.. ... Sanofi

11/16/17 / #20170326298

Auto-injector

According to the invention, an auto-injector for administering a dose of a liquid medicament (m) comprises of a substantially cylindrical housing arranged to contain a pre-filled syringe filled with the medicament (m), a needle shroud slibably arranged with respect to the housing and adapted to rest on the skin of a patient receiving an injection, a releasable drive means arranged within the housing that is capable of, upon release, translating the needle shroud in a proximal direction (p) towards a safe position (ps) and a rotating collar rotatably arranged within the housing. The needle shroud in the safe position (ps) surrounds the injection needle after the injection has been carried out. ... Sanofi

11/16/17 / #20170326290

Medical apparatus package

A package (10) for components of a medical apparatus comprising a plurality of panels (12-20) defining a container (11) having an interior space. A first component of the medical apparatus is disposed within the interior space. ... Sanofi

11/16/17 / #20170326221

Detoxification method for lipopolysaccharide (lps) or lipid a of gram-negative bacteria

The invention relates to a method of detoxifying a lipopolysaccharide (lps) or a lipid a from a gram-negative bacterium, which comprises mixing the lps or the lipid a with a cationic lipid so as to form a complex in which the lps or the lipid a is associated with the cationic lipid. According to the conventional preparation modes, the cationic lipid with the co-lipid, if this latter is present, get(s) structured into complexes i.a. ... Sanofi

11/16/17 / #20170326069

Pharmaceutical composition comprising a glp-1-agonist and methionine

A liquid composition comprising a glp-1 agonist and/or a pharocoligically tolerable salt thereof and, optionally, at least one pharmaceutically acceptable excipient, wherein the composition comprises methionine, as add-on therapy with metformin and/or with long-acting insulin/insulin derivatives where appropriate.. . ... Sanofi

11/09/17 / #the present invention relates to compounds of formula (i):

Sanofi

. . ... Sanofi

11/09/17 / #20170321241

21-hydroxylation of steroids

Generally, the present invention relates to the field of steroid hydroxylation. More specifically, the present invention relates to a method for the 21-hydroxylation of steroids in cells. ... Sanofi

11/09/17 / #20170320967

Trispecific and/or trivalent binding proteins

The disclosure provides trispecific and/or trivalent binding proteins comprising four polypeptide chains that form three antigen binding sites that specifically bind one or more target proteins, wherein a first pair of polypeptides forming the binding protein possess dual variable domains having a cross-over orientation and wherein a second pair of polypeptides forming the binding protein possess a single variable domain. The disclosure also provides methods for making trispecific and/or trivalent binding proteins and uses of such binding proteins.. ... Sanofi

11/09/17 / #20170319788

Space saving drug injection device

The present disclosure relates to an injection device for setting and dispensing of a dose of a medicament, the device including an elongated housing to accommodate a cartridge filled with the medicament and sealed with a piston, a piston rod extending along a first axis and being threadedly or slidingly engaged with the housing to apply a distally directed thrust to the piston of the cartridge, a drive member rotationally or threadedly engaged with the piston rod and having a wheel section or geared section, and a drive sleeve extending along a second axis at a radial distance from the first axis and having a geared section to mesh with the wheel section or geared section of the drive member, wherein a first radial distance between first and second axes at a distal end of the drive sleeve differs from a second radial distance between first and second axes at a proximal end of the drive sleeve.. . ... Sanofi

11/09/17 / #20170319784

Drive mechanism for use in a drug delivery device

The disclosure is directed to a drive mechanism for use in a drug delivery device having a cartridge, the mechanism comprising a base element, a toothed piston rod movable from a first retracted position corresponding to a full cartridge to a second extended position corresponding to an empty cartridge, wherein the piston rod is guided within and movable relative to the base portion, and a drive gear having a pinion, which is rotatably held in the base element and in meshed engagement with the toothed piston rod, wherein the toothed piston rod comprises multiple rigid rod pieces which are connected by hinges, and a drive spring, which is fixed to the base element with one end and fixed to the drive gear with another end and which exerts a force or torque to the drive gear for rotating the drive gear relative to the base element, which rotation results in a movement of the toothed piston rod. The drive spring is charged during manufacture or assembly, wherein the energy stored in the drive spring is sufficient to move the piston rod (from the first to the second position. ... Sanofi

11/09/17 / #20170319538

Solid pharmaceutical compositions containing benzofuran derivatives

The present invention relates to a solid pharmaceutical composition for oral administration characterized in that it comprises a benzofuran derivative with antiarrhythmic activity, or one of the pharmaceutically acceptable salts thereof, as an active principle, and a pharmaceutically acceptable nonionic hydrophilic surfactant optionally in combination with one or more pharmaceutical excipients.. . ... Sanofi

10/26/17 / #20170305932

Fused pentacyclic imidazole derivatives

A series of fused pentacyclic imidazole derivatives, being potent modulators of human tnfa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders. In particular, the present invention is concerned with 6,7-dihydro-7,14-methanobenzimidazo[1,2-b][2,5]benzodiazocin-5(14h)-one derivatives and analogs thereof.. ... Sanofi

10/26/17 / #20170304559

Medicament delivery device and cartridge

Described is a cartridge comprising a body adapted to contain a medicament, a bung slidably disposed in the body and having a distal face and a proximal face, and a light element coupled to a component of the cartridge. Further described is a medicament delivery device comprising the cartridge, a first receiver adapted to receive an optical signal from the light element and convert the optical signal into a first electrical signal, and a second receiver adapted to receive an optical signal from the light element and convert the optical signal into a second electrical signal.. ... Sanofi

10/26/17 / #20170304554

Insert and drug delivery device herewith

The present disclosure is generally directed to a drug delivery device for selecting and dispensing a number of user variable doses of a medicament and to an insert for such a device. The insert comprises a cup-shaped body with a distal end and a proximal end. ... Sanofi

10/26/17 / #20170304552

A drug delivery device with at least one transparent region of housing

The present disclosure relates to a drug delivery device comprising: a housing; a moveable number sleeve disposed within the housing and having numbers printed thereon; and a transparent window occupying an aperture of the housing and covering the number sleeve such that the number sleeve is visible through the transparent window. At least one region of the housing located adjacent to the transparent window is transparent to visible light and is in optical communication with the transparent window.. ... Sanofi

10/26/17 / #20170304551

Drug injection device with resettable mechanism allowing piston rod retraction upon drug cartridge change

A drug delivery device for selecting and dispensing a number of user variable doses of a medicament. The device comprises a housing, a dose setting element rotatable relative to the housing during dose setting and dose dispensing, a drive member coupled to the dose setting member via a clutch, and a piston rod coupled to the housing and to the drive member. ... Sanofi

10/26/17 / #20170304550

Dosing assembly for drug delivery device with different leads and multi-start thread section

The present invention is generally directed to an assembly for a drug delivery device comprising a first threaded member (50, 50′), a second threaded member (40, 60′) with a longitudinal axis and a thread (61), having at least two consecutive portions (62, 63, 64) with different leads. The first threaded member (50, 50′) and the second threaded member (40, 60′) are adapted and arranged to rotate with respect to one another about the longitudinal axis of the second threaded member (40, 60′) during dose setting operation of the assembly, the first threaded member (50, 50′) thereby being axially displaced along the second threaded member (40, 60′) from a start position to an end position with respect to the second threaded member (40, 60′) due to the mechanical cooperation of the first threaded member (50, 50′) with the thread (61). ... Sanofi

10/26/17 / #20170304549

A supplementary device for attachment to a drug injection device for monitoring injection doses having ocr imaging system with glare reduction

The subject matter described herein relates to a supplementary device for attachment to an injection device, the supplementary device comprising: a first imaging arrangement and a second imaging arrangement each configured to capture an image of a moveable number sleeve of the injection device from different respective angles. The supplementary device also comprises a plurality of light sources and a processor arrangement configured to control operation of the first imaging arrangement and the second imaging arrangement and the plurality of light sources and to receive image data from each of the imaging arrangements, wherein the processor arrangement is configured to combine images captured by the first imaging arrangement and the second imaging arrangement into a single image.. ... Sanofi

10/26/17 / #20170304546

Apparatus for determining information associated with reflection characteristics of a surface

Apparatus comprising: a sensor configured to generate sensor output dependent on an intensity of light incident on the sensor and having a field of view directed at an external surface in use; an illumination source configured to emit light onto the external surface in use; a window located such as to allow light to pass from the illumination source to the external surface and to allow light to pass to the sensor from the external surface in use; a shield coupled to or integral with the window, the shield being substantially opaque to substantially all wavelengths of light detectable by the sensor and defining an aperture which limits the field of view of the sensor; and a processor configured to use the sensor output to determine information associated with reflection characteristics of the external surface.. . ... Sanofi

10/26/17 / #20170304545

Apparatus for determining information associated with reflection characteristics of a surface

Apparatus for determining information associated with reflection characteristics of a surface comprising a sensor (60) configured to generate sensor output dependent on an intensity of light incident on the sensor and having a field of view directed at an external surface (57) in use; an illumination source (58) configured to emit light onto the external surface in use; an optically transparent window (61) located such as to allow light to pass from the illumination source to the external surface and to allow light to pass to the sensor from the external surface in use; a light concentrator (66) fixed to or integral with the window, the light concentrator being configured to concentrate at least some light from the illumination source onto the external surface in use such that the concentrated light may be reflected from the external surface onto the sensor via the window; and a processor (40) configured to use the sensor output to determine information associated with reflection characteristics of the external surface.. . ... Sanofi

10/26/17 / #20170304542

Activating mechanism for a medicament delivery device and medicament delivery device

The invention relates to an activating mechanism for a medicament delivery device (1), comprising: —an outer body (8), —a cartridge (2) containing a dosage of a medicament and sealed with a sealing element (2.1) that is arranged across an open distal end of the cartridge (2), —a cartridge carrier (4) adapted to hold the cartridge (2), —a needle safety mechanism adapted to hold a double-ended hollow needle (6) and to relatively move along a longitudinal axis (l) with respect to the cartridge (2) and to the outer body (8) to cover or to expose the needle (6), —wherein in an initial position (p1) of the medicament delivery device (1), the double-ended hollow needle (6) is spaced from the cartridge (2) in a distal direction (d), and —wherein when the needle safety mechanism is pressed into the outer body (8), a proximal end of the needle (6) pierces the sealing element (2.1). The invention further relates to a medicament delivery device (1) comprising such an activating mechanism.. ... Sanofi

10/26/17 / #20170304537

Drive mechanism of an injection device

A drive mechanism of an injection device for setting and dispensing of a dose of a medicament includes a body accommodating a cartridge filled with a medicament, an insert axially displaceable inside the body between a proximal operating position and a distal reset position, a piston rod to operably engage with a piston of the cartridge, a drive sleeve rotationally coupled with the piston rod and is rotationally lockable to the body for setting of a dose and rotationally releasable from the body for dispensing of a dose, respectively. The drive sleeve is axially displaceable relative to the body from a proximal operating position into a distal reset position through an axial connection of the insert and the drive sleeve, where the drive sleeve is rotationally released from the body when in the distal reset position.. ... Sanofi

10/26/17 / #20170304426

Vaccine compositions against dengue virus diseases

The present invention relates to vaccine compositions that are useful in a method of protecting a human subject against dengue disease.. . ... Sanofi

10/26/17 / #20170304423

Compositions and methods for immunizing against c. difficile

This disclosure relates to methods for eliciting an immune response against c. Difficile toxin a and toxin b in an adult human subject. ... Sanofi

10/12/17 / #20170290996

Dispense interface with lockout element

The invention is related to an apparatus comprising a dispense interface comprising a lockout element for use with a drug delivery device, the lockout element comprising at least one spring component removeably maintained in a respective first position such that when the dispense interface is first attached and then removed from said drug delivery device, each spring component moves into a respective second position, which respective second position is configured to prevent said dispense interface from being reattached to a drug delivery device.. . ... Sanofi

10/12/17 / #20170290977

Large volume skin patch medicament delivery device with integrated skin sterilization mechanism for the injection site

A skin-patch type medicament delivery device (10, 30, 50) comprises a housing (11) containing a medicament delivery mechanism (12) including an injection needle (13). An adhesive surface (19) is provided for securing the housing (11) to a patient's skin during a medicament delivery process. ... Sanofi

10/05/17 / #20170281874

Drug delivery device and method for a drug delivery device

A drug delivery device (1) is provided comprising a housing (4) comprising a distal end and a proximal end and a cartridge (3) adapted and arranged to contain at least one dose of a drug (16), a bung (5) being movably arranged within the cartridge (3). In an initial state of the device (1), the bung (5) is arranged in a proximal end position with respect to the cartridge (3). ... Sanofi

10/05/17 / #20170281861

Medicament delivery device with rotatable housing on a base

A medicament delivery device (10) comprises a medicament delivery mechanism including an injection needle (23). A housing (11) contains at least one component of the medicament delivery mechanism. ... Sanofi

10/05/17 / #20170281733

Combination of an insulin and a glp-1 agonist

The invention relates to a drug comprising at least one insulin and at least one glp-1 receptor agonist.. . ... Sanofi

09/28/17 / #20170273936

Use of dronedarone for the preparation of a medicament for use in the prevention of cardiovascular hospitalization or of mortality

Methods of using dronedarone or a pharmaceutically acceptable salt thereof, for the preparation of a medicament for use in the prevention of cardiovascular hospitalization or of mortality, articles of manufacture and packages related thereto.. . ... Sanofi

09/21/17 / #the present invention relates to methods for treating diseases or conditions in which proprotein convertase subtilisin/kexin type 9 (pcsk9) expression or activity causes an impact by administration of pcsk9-specific antibodies or antigen-binding fragments thereof and preferably by additional administration of an inhibitor of 3-hydroxy-3-methyl-glutaryl-coa reductase (hmg-coa reductase). the present invention further relates to pcsk9-specific antibodies or antigen-binding fragments thereof for use in the treatment of diseases or conditions in which pcsk9 expression or activity causes an impact.

Sanofi Biotechnology

. . ... Sanofi

09/21/17 / #20170267734

Novel proteins specific for pyoverdine and pyochelin

The present disclosure provides hngal muteins that bind a pyoverdine family member or pyochelin and can be used in various application including pharmaceutical applications, for example, to inhibit or reduce growth of p. Aeruginosa. ... Sanofi

09/21/17 / #20170267685

Heteroaryl compounds and uses thereof

The present invention relates to compounds useful as inhibitors of protein kinases, containing a cysteine residue in the atp binding site. The invention further provides for pharmaceutically acceptable compositions comprising therapeutically effective amounts of one or more of the protein kinase inhibitor compounds and methods of using said compositions in the treatment of cancers and carcinomas.. ... Sanofi

09/21/17 / #20170266388

Dose setting mechanism and drug delivery device herewith

The present invention is generally directed to a dose setting mechanism and a drug delivery device herewith, i.e. A handheld injection device for selecting and dispensing a number of user variable doses of a medicament. ... Sanofi

09/21/17 / #20170266384

Display and drug delivery device

The present disclosure is generally directed to a drug delivery device for selecting and dispensing a number of user variable doses of a medicament and to a non-numerical display for such a device. The display comprises a housing with at least one window, a dosing element movable relative to the housing during dose setting and/or dose dispensing, and a movable indicator element visible through the at least one window the indicator element is coupled to the dosing element and/or to the housing such that it moves not proportional to the dosing element.. ... Sanofi

09/21/17 / #20170266370

Injection devices with tissue swelling detection

An injection device comprising a housing; a securing arrangement for securing the injection device against an injection site of a patient; a needle insertion mechanism configured to cause insertion of a needle into a patient when the injection device is secured against the injection site of the patient; a medicament delivery arrangement configured to cause injection of a medicament into tissue of the patient at the injection site; and a medicament retention sensor configured to detect retention of medicament in the tissue of the patient at the injection site, wherein the injection device is configured to respond to detection of swelling of the tissue of the patient at the injection site by causing provision of an alert and/or by causing suspension or halting of injection of medicament.. . ... Sanofi

09/14/17 / #20170259015

Skin-attachable drug injection device with detachment sensor

A skin-patch type large volume medicament injection device (1) comprising an adhesive surface (21/23) for attachment to the skin and a plurality of contact sensors (24) configured to output a signal representing a degree of detachment of the device from the injection site, and an alarm and control function which outputs an alert to the user based on the signal received from the sensors and stops the injection in case the degree of detachment is too large to guarantee further save injection.. . ... Sanofi

09/14/17 / #20170259014

Skin-patch type large volume bolus drug injector with medicament pre-heating

A skin-patch type large volume drug delivery device (1) comprising a heat exchanger (24) to extract thermal energy from the body/skin surface of the user and to supply the extracted thermal energy to increase the temperature of the medicament. Alternatively or in addition, a peltier element (35) can be used for the same purpose. ... Sanofi

09/14/17 / #20170258994

Injection devices triggered by mechanical key

An injection device (100) comprises: a needle insertion mechanism (111); a medicament delivery arrangement (123) configured to cause injection of a medicament into a patient; and a cavity (102) having an opening (103) for receiving a key device (104). The injection device is configured to respond to detecting the presence of the key device in the cavity by triggering operation of the injection device. ... Sanofi

09/14/17 / #20170258987

Triggering injection status information display on a mobile device via tapping the housing of a skin-attachable drug injection device

A skin attachable drug injection device (1), comprising an accelerometer (26) able to detect the user tapping against the housing (2) of the device and to generate an electrical signal to the device controller (16), which recognizes the signal as a user request for information regarding the ongoing delivery of the medicament, and a transmitter (30) which in response wirelessly transmits said information (e.g. The expected remaining during of the injection) to a separate portable user device having a display (e.g. ... Sanofi

09/07/17 / #20170252509

Medicament delivery device with sterilizing pad

A medicament delivery device comprises a housing containing a medicament delivery mechanism including an injection needle. The housing includes a contact surface having a first adhesive layer. ... Sanofi

09/07/17 / #20170252508

Providing temperature-based feedback regarding delivery of a medicament

A device configured to deliver a medicament to a user by injection, comprising an injection feedback apparatus configured to apply temperature-based feedback to the user regarding the delivery of the medicament.. . ... Sanofi

09/07/17 / #20170252507

Packaging for medical device and medicament

A packaging for a medical device and medicament comprising a packaging body having first and second regions. A medicament delivery device is received in the first region and a medicament container is received in the second region. ... Sanofi

09/07/17 / #20170252452

Film coated tablet for the treatment of acute pain

The invention relates to a film coated tablet for the treatment of acute pain containing 400 mg of ibuprofen, 100 mg of caffeine, 50 to 100 mg of one or more disintegrating agents and to a process for the preparation of the film coated tablet according to the invention.. . ... Sanofi

09/07/17 / #20170252346

Pharmaceutical composition for the treatment of acute tooth or jaw pain

The invention relates to a pharmaceutical composition for oral administration for the treatment of acute dental or jaw pain, containing ibuprofen, caffeine and at least one distintegrant.. . ... Sanofi

08/31/17 / #20170247319

(z)-2-cyano-3-hydroxy-but-2-enoic acid-(4'-trifluoromethylphenyl)-amide tablet formulations with improved stability

The invention relates to solid pharmaceutical compositions comprising (z)-2-cyano-3-hydroxy-but-2-enoic acid-(4′-trifluoromethylphenyl)-amide, as well as a process for the preparation of the same, methods of using such compositions to treat subjects suffering from autoimmune diseases in particular systemic lupus erythematosus or chronic graft-versus-host disease, multiple sclerosis or rheumatoid arthritis.. . ... Sanofi

08/31/17 / #20170246398

Auto-injector

An auto-injector for administering a dose of a liquid medicament has a tubular chassis telescopable in a tubular case, a carrier subassembly comprising a tubular carrier slidably arranged relative to the chassis inside the case, where the carrier adapted to contain a syringe with a hollow injection needle. The injector has a drive spring and a plunger for forwarding load of the drive spring to a stopper of the syringe, wherein the syringe is lockable for joint axial translation with the carrier. ... Sanofi

08/31/17 / #20170246397

Auto-injector

An auto-injector for administering a dose of a liquid medicament includes a case and a carrier subassembly with a carrier slidably arranged inside the case. The carrier can contain a syringe with a hollow injection needle, a drive spring and a plunger for forwarding drive spring load to a syringe stopper. ... Sanofi

08/24/17 / #20170239423

Resettable drug delivery device

The present disclosure is generally directed to a resettable drug delivery device for selecting and dispensing a number of user variable doses of a medicament. The drug delivery device comprises a housing, a cartridge holder, releasably attached to the distal end of the housing, a piston rod, engaging a housing insert and a drive member, a dose setting member, guided within the housing to allow rotation of the dose setting member during dose setting and dose dispensing, and a clutch for rotationally coupling the drive member and the dose setting member. ... Sanofi

08/17/17 / #this invention is directed to a compound of formula (i):

Sanofi

. . ... Sanofi

08/17/17 / #compounds of formula (i):

Sanofi

. . ... Sanofi








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