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Siemens Healthcare Diagnostics Inc
Siemens Healthcare Diagnostics Inc A Corporation Of California
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Siemens Healthcare Diagnostics Inc patents


Recent patent applications related to Siemens Healthcare Diagnostics Inc. Siemens Healthcare Diagnostics Inc is listed as an Agent/Assignee. Note: Siemens Healthcare Diagnostics Inc may have other listings under different names/spellings. We're not affiliated with Siemens Healthcare Diagnostics Inc, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "S" | Siemens Healthcare Diagnostics Inc-related inventors


 new patent  Pipette components useful for medical diagnostics

A pipette is described having a tube, a pressure mechanism, and at least one reagent pad. The tube has a first end, a second end opposite the first end, and a sidewall extending between the first end and the second end, with the sidewall defining an interior cavity. The pressure... Siemens Healthcare Diagnostics Inc

 new patent  Model-based methods and classifying an interferent in specimens

A model-based method of inspecting a specimen for presence of one or more interferent, such as Hemolysis, Icterus, and/or Lipemia (HI L) is provided. The method includes generating a pixelated image of the specimen in a first color space, determining color components (e.g., an a-value and a b-value) for pixels... Siemens Healthcare Diagnostics Inc

 new patent  Quantitation of functional groups on solid supports

Processes for quantifying an amount of functional groups immobilized on a solid support are described herein. The processes allow for determining whether sufficient functional groups are provided on a solid support for the attachment of a first binding pair member for the detection of a target analyte.... Siemens Healthcare Diagnostics Inc

 new patent  Image-based tray alignment and tube slot localization in a vision system

A method of tube slot localization is provided using a tray coordinate system and a camera coordinate system. The method includes receiving, a series of images from at least one camera of a tray comprising tube slots arranged in a matrix of rows and columns. Each tube slot is configured... Siemens Healthcare Diagnostics Inc

 new patent  Shutter assembly for a luminescence-based sample analyzer

A shutter assembly includes a first shutter blade having a first toothed arm extending therefrom and a first light transmitting aperture therein, and a second shutter blade positioned adjacent and parallel to the first shutter blade. The second shutter blade has a second toothed arm extending therefrom and a second... Siemens Healthcare Diagnostics Inc

 new patent  Classification of barcode tag conditions from top view sample tube images for laboratory automation

Embodiments are directed to classifying barcode tag conditions on sample tubes from top view images to streamline sample tube handling in advanced clinical laboratory automation systems. The classification of barcode tag conditions leads to the automatic detection of problematic barcode tags, allowing for a user to take necessary steps to... Siemens Healthcare Diagnostics Inc

 new patent  Image-based tube slot circle detection for a vision system

Embodiments provide a method of using image-based tube top circle detection that includes extracting, from one of a series of images of a tube tray, a region of interest (ROI) patch having a target tube top circle and boundaries constrained by two dimensional (2D) projections of different types of tube... Siemens Healthcare Diagnostics Inc

Locality-based detection of tray slot types and tube types in a vision system

A method for detecting properties of sample tubes is provided that includes extracting image patches substantially centered on a tube slot of a tray or a tube top in a slot. For each image patch, the method may include assigning a first location group defining whether the image patch is... Siemens Healthcare Diagnostics Inc

Pipette cleaning methods and apparatus, neutralizing liquid vessels, and methods of reducing carryover

Methods and apparatus configured and adapted to provide less carryover in an automated clinical analyzer are disclosed. The methods include immersing a pipette into a neutralizing liquid vessel and aspirating a neutralizing liquid (e.g., a hypochlorite solution) into an interior of a pipette. The aspirated portion of the neutralizing liquid... Siemens Healthcare Diagnostics Inc

Improved magnesium ion selective membranes

The present invention is directed to membranes, sensors, systems and process for the detection of magnesium ions in protein-containing samples. The novel membranes, sensors, systems, and processes are based upon the discovery that the lipophilcity of the plasticizer (or blend of plasticizers) utilized in the formulation of magnesium ion selective... Siemens Healthcare Diagnostics Inc

Diagnostics and therapeutics for diseases associated with g-protein coupled receptor adipor2 (adipor2)

The invention provides human AdipoR2 which is associated with the cardiovascular diseases, dermatological diseases, gastroenterological diseases, cancer, hematological diseases, respiratory diseases, inflammation, neurological diseases, urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, dermatological diseases, gastroenterological diseases, cancer,... Siemens Healthcare Diagnostics Inc

Proteolytic digestion of cardiac troponin i

A fluid sample container comprising a protease, when a sample fluid is placed in the fluid sample container the protease breaking a target analyte in the sample fluid into at least two peptides, the at least two peptides being smaller than the original target analyte.... Siemens Healthcare Diagnostics Inc

Methods and systems for improving precision of measurements for reduced sample volumes

There is described a process for improving precision in an analytical test for a target analyte in a sample. The process includes prior to analyzing the sample for a target analyte via a biosensor, introducing to an analytical zone defined by the biosensor fluid comprising an effective amount of the... Siemens Healthcare Diagnostics Inc

Hemolysis detection using intracellular analyte concentrations

This disclosure relates to the detection of whole blood hemolysis in a sample of whole blood. More specifically, this disclosure describes detecting hemolysis using one or more novel ratios of intercellular concentrations of whole blood analytes.... Siemens Healthcare Diagnostics Inc

Sensor array with anti-diffusion region(s) to extend shelf life

The inventive concepts disclosed herein are generally directed to a sensor array device that has a prolonged shelf life but requires only a minimal amount of sample volume in order to test two or more analytes concurrently. In order to ensure the sensor array has a sufficient shelf life, anti-diffusion... Siemens Healthcare Diagnostics Inc

Sandwich assay design for small molecules

Methods are disclosed of designing antibodies for a sandwich assay for a small molecule having a molecular weight of about 500 to about 2,000. The method comprises preparing a first antibody that binds to the small molecule, and preparing a second antibody that binds to the small molecule at a... Siemens Healthcare Diagnostics Inc

Conjugates for assays for oxycodone and oxymorphone

Compositions, methods, and kits are disclosed directed at haptens, immunogens and immunoassays for oxycodone and metabolites thereof. The compounds are exemplified by compounds of the Formula I. The method comprises providing in combination in a medium (i) a sample suspected of containing oxycodone and/or oxycodone metabolites, a compound of the... Siemens Healthcare Diagnostics Inc

Accurate assay measurement of hydrophobic haptenic analytes

Methods are disclosed for determining an actual concentration of a hydrophobic haptenic analyte in an unknown sample suspected of containing the hydrophobic haptenic analyte, wherein the unknown sample is suspected of containing an interfering substance. A first assay method is conducted on an unknown sample to obtain a measured concentration... Siemens Healthcare Diagnostics Inc

Hydrophilic high quantum yield acridinium esters with improved stability and fast light emission

Hydrophilic, high quantum yield, chemiluminescent acridinium compounds with increased light output, improved stability, fast light emission and decreased non specific binding are disclosed. The chemiluminescent acridinium esters possess hydrophilic, branched, electron-donating functional groups at the C2 and/or C7 positions of the acridinium nucleus.... Siemens Healthcare Diagnostics Inc

Sample introduction system

A sample port system/device associated with a fluid collection device is provided and is configured to receive fluid-containing devices of varying diameters. A method of improving the work flow and safety involved in acquiring and/or testing fluid samples using such sample port system/device is also provided.... Siemens Healthcare Diagnostics Inc

Phase-modulated standing wave mixing apparatus and methods

Disclosed are mixing apparatus adapted to provide mixing of components in an automated analyzer. The mixing apparatus includes a reservoir configured to contain a coupling liquid, a transducer configured to be driven at a frequency and communicate with the coupling liquid, and a signal generation unit configured to provide a... Siemens Healthcare Diagnostics Inc

Diagnostic devices with modifiable hydrophobic surfaces

A diagnostic device 10 for screening for a target analyte in a sample is provided. The diagnostic device 10 comprises a substrate 12 and a hydrophobic material 20 disposed on the substrate. The hydrophobic material 20 is selected to be converted from the hydrophobic material 20 to a hydrophilic material... Siemens Healthcare Diagnostics Inc

Creatinine biosensor and using the same

This disclosure relates to creatinine biosensors and the uses thereof. More specifically, this disclosure describes potentiometric creatinine sensors which utilizes one or both of a type of enzyme capable of directly producing ammonium ions (NH4+) as a consequence of coming into contact with a liquid sample and an internal fill... Siemens Healthcare Diagnostics Inc

Method of normalizing biological samples

The present disclosure relates to normalization of biological samples, particularly samples comprising nucleic acids to be sequenced. The normalization protocols described herein may be utilized across multiple samples to cap total stoichiometric input and minimize variations in transcript abundance on a per-sample basis in a multiplexed fashion to dramatically increase... Siemens Healthcare Diagnostics Inc

Hemolysis detection device, system and method

Aspects of the present invention are directed to devices, systems and methods that enable the quick and reliable detection of hemolysis in a sample such that a sample which exhibits an unacceptable level of hemolysis can be flagged or disregarded in an associated diagnostic test.... Siemens Healthcare Diagnostics Inc

Vacuum-assisted plasma separation

A plasma separation system and process for providing filtered plasma from a blood sample is described. The system may include a blood separation well having a separation membrane for filtering the blood sample. The filtering process may be aided by the use of a negative or positive pressure source attached... Siemens Healthcare Diagnostics Inc

Light and shutter for a sample analyzer

A sample analyzer has a support for an assay sample vessel, a detector, and a shutter assembly. The assay sample vessel contains an assay sample within an assay sample reservoir. The detector has an optical axis aligned with the assay sample reservoir, so as to detect luminescence from the assay... Siemens Healthcare Diagnostics Inc

Random access polymerase chain reaction testing

A random access, high-throughput system and method for preparing a biological sample for polymerase chain reaction (PCR) testing are disclosed. The system includes a nucleic acid isolation/purification apparatus and a PCR apparatus. The nucleic acid isolation/purification apparatus magnetically captures nucleic acid (NA) solids from the biological sample and then suspends... Siemens Healthcare Diagnostics Inc

Low sample volume sensing device

In one aspect, the inventive concepts disclosed herein are directed to a sensor assembly which contains a first planar substrate and a second planar substrate which respectively support opposing sensor arrays and contains an integrated flow path extending between the first and second substrates. Sensor assembly contains a first planar... Siemens Healthcare Diagnostics Inc

Microfluidic test cartridge with no active fluid control

A microfluidic test device and analyzer, the test device includes a sample well, at least one reaction well and a calibrator well fluidicly connected to a waste well which in turn is connected to a pump port. When vacuum pressure from the analyzer is applied through the pump port, fluid... Siemens Healthcare Diagnostics Inc

Sensor array

In one illustrative embodiment, a test strip with a first planar substrate has coplanar electrodes on a first planar surface and a second planar substrate (which opposes the first surface of the first planar substrate) has coplanar electrodes on a second planar surface. The first planar surface of the first... Siemens Healthcare Diagnostics Inc

Robotic pick and place device with combined gripping and rotational functionality

A pick and place device for use in an in vitro diagnostics automation system is provided that includes a motor and a rotatable motor shaft coupled to the motor and a gripping assembly. The gripping assembly includes a yoke selectively coupled to the rotatable motor shaft and configured to rotate... Siemens Healthcare Diagnostics Inc

Luminescent oxygen channeling immunoassay utilizing three antibodies and methods of production and use thereof

A chemiluminescent detection system, as well as kits and microfluidics devices containing same, are disclosed. Methods of using the system, kits, and devices are also disclosed. The first, second, and third antibodies or binding fragments thereof may be provided in any form that allows these antibodies/binding fragments to function in... Siemens Healthcare Diagnostics Inc

Reader device and signal amplification

Fluid collection devices, analysis instruments and methods for making and using same are disclosed. The fluid collection device is provided with a device and an electrochemical cell. The device has first and second walls defining a microfluidic channel, and a sample application port communicating with the microfluidic channel. The first... Siemens Healthcare Diagnostics Inc

Binding partners specific for vitamin d epimers in vitamin d assays

Methods include determining an amount of vitamin D analyte in a sample suspected of containing the vitamin D analyte. A combination is provided in an assay medium that includes the sample, a vitamin D epimer antibody that is specific for epimers of the vitamin D analyte wherein the vitamin D... Siemens Healthcare Diagnostics Inc

06/08/17 / #20170160295

Methods and reagents for determining isomeric analytes

Methods include determining in a sample an amount of a first isomeric analyte and a second isomeric analyte. A first measurement value and a second measurement value are determined. The first measurement value represents a total amount of the first isomeric analyte and the second isomeric analyte. The second measurement... Siemens Healthcare Diagnostics Inc

06/08/17 / #20170160297

Waste ramp for reagent cards

An automated analyzer for reagent cards having a leading end, a trailing end and a length between the leading end and the trailing end comprises a travel surface assembly having a card travel surface and an edge. A test analyzing mechanism is adjacent to the travel surface, and a waste... Siemens Healthcare Diagnostics Inc

06/01/17 / #20170153241

Cell response assay for cancer and methods of producing and using same

A cell response assay for cancer is provided. In the assay, the levels of a cancer cell type biomarker, a chemo resistance biomarker and a metastatic potential biomarker are simultaneously measured in a biological sample.... Siemens Healthcare Diagnostics Inc

06/01/17 / #20170153254

Assays for vitamin d epimers

Methods include determining an amount of an epimeric vitamin D analyte in a sample suspected of containing the epimeric vitamin D analyte. A combination is provided in an assay medium that includes the sample and a vitamin D epimer antibody that is specific for the epimeric vitamin D analyte. The... Siemens Healthcare Diagnostics Inc

05/18/17 / #20170137805

Selective nucleic acid separation

Nucleic acids in non-rare cells in a sample containing non-rare cells and rare cells are selectively released from the non-rare cells. The sample is combined with an aqueous medium, and the combination is held for a period of time and at a temperature for selectively releasing nucleic acids from the... Siemens Healthcare Diagnostics Inc

05/18/17 / #20170137894

Oligonucleotides and methods for detecting kras and pik3ca mutations

Provided are oligonucleotides that are capable of detecting KRAS and PIK3CA mutations in both cancer patients and healthy individuals with high specificity in kPCR assays. When the oligonucleotides are used as forward primers in conjunction with a defined genotyping algorithm spreadsheet, the primers are capable of enhancing detection of KRAS... Siemens Healthcare Diagnostics Inc

05/18/17 / #20170137901

Reagents and methods for detecting hcv

The present disclosure relates to oligonucleotide sequences for amplification primers and their use in performing nucleic acid amplifications of HCV, in particular regions that encode the NS3 polypeptide. In some embodiments the primers are used in nested PCR methods for the detection or sequencing of HCV NS3. The oligonucleotide sequences... Siemens Healthcare Diagnostics Inc

05/11/17 / #20170131191

Feedback control for improved rare cell detection

There is provided a system (10) and method (100) for improving ICC and/or ISH rare cell detection by lowering background noise and providing enhanced detection of rare cells (15). In an embodiment, background noise for an ICC and/or an ISH rare cell detection assay is reduced and rare cell signaling... Siemens Healthcare Diagnostics Inc

05/11/17 / #20170132450

Analyzing digital holographic microscopy data for hematology applications

A method for analyzing digital holographic microscopy (DHM) data for hematology applications includes receiving a plurality of DHM images acquired using a digital holographic microscopy system. One or more connected components are identified in each of the plurality of DHM images and one or more training white blood cell images... Siemens Healthcare Diagnostics Inc

05/04/17 / #20170120164

Fluidic device and degassing method

A fluidic device and a method for degassing a fluidic device are presented. The fluidic device includes a plurality of fluidic components such as channels, chambers, and integrated valves and pumps, etc. A porous membrane is disposed on a degassing area of the fluidic device for removing gas (such as,... Siemens Healthcare Diagnostics Inc

05/04/17 / #20170121426

Binding partners specific for vitamin d epimers

Antibodies are raised against compounds of Formula (I) where Z is an immunogenic carrier. These compounds are capable of binding specifically to corresponding antibodies. The antibodies are specific for epimers of vitamin D. Antibodies in accordance with the principles described herein may be employed to minimize or eliminate 3-epimer cross-reactivity... Siemens Healthcare Diagnostics Inc

05/04/17 / #20170122901

Reagents for potentiometric magnesium ion selective electrode sensors and methods of production and use thereof

Reagents are disclosed for use with potentiometric magnesium ion selective electrodes, along with kits containing same as well as methods of use thereof. Before explaining at least one embodiment of the inventive concept(s) in detail by way of exemplary drawings, experimentation, results, and laboratory procedures, it is to be understood... Siemens Healthcare Diagnostics Inc

05/04/17 / #20170124704

Drawer vision system

Methods and systems for detecting properties of sample tubes in a laboratory environment include a drawer vision system that can be trained and calibrated. Images of a tube tray captured by at least one camera are analyzed to extract image patches that allow a processor to automatically determine if a... Siemens Healthcare Diagnostics Inc

04/27/17 / #20170113217

Sample delivery system

Inventive concepts disclosed herein are directed to a capillary tube and a force assisted sample ejection mechanism. The capillary tube may be at least one of dissolvable or breakable. The force assisted sample ejecting mechanism releasing at least part of the sample of the first liquid from the capillary tube... Siemens Healthcare Diagnostics Inc

04/27/17 / #20170114012

Compositions relating to vitamin d

This invention relates to compositions, methods and kits for determining the presence and/or amount of vitamin D analytes, including vitamin D isomers, and metabolites thereof in a sample suspected of containing the same. Compounds include compounds of the Formula I, namely, (R1)p-(L)q-Z wherein R1, L, p and q are as... Siemens Healthcare Diagnostics Inc

04/20/17 / #20170108516

Detection of hemolysis using a chromatographic detection pad

In one aspect, the inventive concepts disclosed herein are directed to a chromatographic assay device for detecting the presence of free hemoglobin in a whole blood sample. The device comprising a chromatographic detection pad with a sample application site and a detection side. The chromatographic detection pad defines a path... Siemens Healthcare Diagnostics Inc

04/13/17 / #20170102390

Rare molecule detection

A concentrated sample having enhanced concentration of the one or more different populations of target rare molecules is incubated with, for each different population of target rare molecules, a particulate or non-particulate affinity agent that comprises a specific binding partner that is specific for and binds to a target rare... Siemens Healthcare Diagnostics Inc

03/23/17 / #20170082646

Method and reducing carryover of reagents and samples in analytical testing

A method of reducing carryover of liquids, such as reagent and/or samples, in analytical or immunoassay testing. The method includes providing an incubation member including a plurality of reaction vessels thereon, pre-assigning certain ones of the reaction vessels in the incubation member for only first test types or certain reagent... Siemens Healthcare Diagnostics Inc

02/23/17 / #20170053399

Method and processing block to be processed of urine sediment image

Provided in the present invention are a method and apparatus for processing a block to be processed of a urine sediment image. The method comprises: calculating a variable number of local feature vectors of a block to be processed, wherein the local feature vector is a vector representing a feature... Siemens Healthcare Diagnostics Inc

02/23/17 / #20170053400

Method and processing block to be processed of urine sediment image

Concepts herein relate to processing urine sediment images. An example method comprises: approximating the color of a pixel in a block to be processed to one of the kc colors in a code book, wherein the code book is a set of the kc colors generated in a set of... Siemens Healthcare Diagnostics Inc

02/16/17 / #20170043341

Microfluidic device

A microfluidic device 10 is provided that includes a porous substrate 12 and a plurality of reaction channels 14 disposed on a first side 36 of the porous substrate 12. The reaction channels 14 are defined by a barrier material 16 disposed on the substrate 12 in a user-defined pattern... Siemens Healthcare Diagnostics Inc

02/16/17 / #20170045541

Reaction vessel handling apparatus, testing apparatus, and methods using same

Disclosed is a reaction vessel handling apparatus adapted for use in a biological fluid testing apparatus. The reaction vessel handling apparatus includes an incubation member and wash member that are overlapping. A transfer device transfers reaction vessels between the incubation member and wash member at the overlapping portions. Incubation and... Siemens Healthcare Diagnostics Inc

02/16/17 / #20170045545

Mother daughter tube carrier for aliquoters

An analyzer for use with in vitro diagnostics includes an automation system to move a plurality of sample carriers within the system. At least some carriers include a plurality of slots. Each slot is configured to hold one of a plurality of fluid containers. The system also includes a place... Siemens Healthcare Diagnostics Inc

02/16/17 / #20170046621

Method and performing block retrieval on block to be processed of urine sediment image

The inventive concepts herein relate to performing block retrieval on a block to be processed of a urine sediment image. The method comprises: using a plurality of decision trees to perform block retrieval on the block to be processed, wherein each of the plurality of decision trees comprises a judgment... Siemens Healthcare Diagnostics Inc

02/16/17 / #20170046838

Method and processing block to be processed of urine sediment image

In the present invention are a method and apparatus for processing a block to be processed of a urine sediment image. The method comprises: dividing a block to be processed into a plurality of grids; calculating an n-dimensional local feature vector of each grid of the plurality of grids, where... Siemens Healthcare Diagnostics Inc

02/09/17 / #20170036204

Sample collection unit

An insert for a sample collection tube includes a generally hollow tubular body insertable into the sample collection tube. The tubular body is open at least at one end. The tubular body of the insert has an internal cross-sectional area dimensioned to accommodate a width of test strip which comprises... Siemens Healthcare Diagnostics Inc

02/09/17 / #20170038389

Method to screen out false positives in a circulating tumor cell assay

Provided herein are methods of screening a patient sample in a circulating tumor cell assay for false positives as well as methods of performing a circulating tumor cell detection assay. Also provided herein are methods of simultaneously identifying, and methods of distinguishing between, a circulating tumor cell and a circulating... Siemens Healthcare Diagnostics Inc

02/02/17 / #20170030821

Urine sediment analysis workstation

A sediment analysis workstation includes an optical microscope, an image recording device connected to an optical unit of the optical microscope and a user interface device connected to the image recording device. The user interface device comprises one or more processors running computer executable instructions that when executed by the... Siemens Healthcare Diagnostics Inc

02/02/17 / #20170030856

Magnesium sensing membrane for potentiometric ion selective electrode for measuring ionized magnesium and methods of production and use thereof

A magnesium sensing membrane is disclosed for use in a potentiometric ion selective electrode that exhibits improved stability upon exposure to surfactant-containing reagents. Kits containing same are disclosed, along with methods of production and use of the magnesium sensing membrane.... Siemens Healthcare Diagnostics Inc

02/02/17 / #20170030932

Spectroscopic methods for the detection of glycated hemoglobin

Kits, microfluidics devices, and assays for use in methods of spectroscopically determining a ratio of glycated hemoglobin to total hemoglobin in a whole blood sample are disclosed.... Siemens Healthcare Diagnostics Inc

Patent Packs
02/02/17 / #20170032091

Intelligent service assistant inference engine

A method of providing dynamic analysis for troubleshooting in vitro diagnostics instrument issues includes receiving, at a second computing device in communication with a plurality of instruments, identification of an issue associated with a portion of an instrument of the plurality of instruments, the identification received from a first computing... Siemens Healthcare Diagnostics Inc

01/19/17 / #20170016876

Device and unit use sensor testing

An analyte testing material web, method of making the analyte testing material web, and an analyzer are disclosed. The analyte testing material web has a material web and a plurality of distinct sample testing devices. The material web has a first surface, a second surface opposite the first surface, a... Siemens Healthcare Diagnostics Inc

01/19/17 / #20170017538

Intelligent service assistant - instrument side software client

A method of providing troubleshooting for an in vitro diagnostics instrument includes receiving, via a computing device, identification of one of a plurality of issues of the instrument, each of the plurality of issues associated with a portion of the instrument. An ordered list of one or more corrective actions... Siemens Healthcare Diagnostics Inc

01/05/17 / #20170002429

Method for detecting an increased risk or incidence of colorectal cancer

The present invention relates to the methods and products for detection of colorectal cancer. Additionally, the present invention relates to methods and products for determining the probability, risk or incidence of colorectal cancer and of colorectal cancer metastasis. The products and methods of the present invention include detecting the level... Siemens Healthcare Diagnostics Inc








ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009



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