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Siemens Healthcare Diagnostics Inc patents


Recent patent applications related to Siemens Healthcare Diagnostics Inc. Siemens Healthcare Diagnostics Inc is listed as an Agent/Assignee. Note: Siemens Healthcare Diagnostics Inc may have other listings under different names/spellings. We're not affiliated with Siemens Healthcare Diagnostics Inc, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "S" | Siemens Healthcare Diagnostics Inc-related inventors


 new patent  Tube characterization station

Systems and methods for use in an in vitro diagnostics setting may include an automation track, a plurality of carriers configured to carry a plurality of sample vessels along the automation track, and a characterization station including a plurality of optical devices. A processor, in communication with the characterization station, can be configured to analyze images to automatically characterize physical attributes related to each carrier and/or sample vessel. ... Siemens Healthcare Diagnostics Inc

Analyzing digital holographic microscopy data for hematology applications

A method for analyzing digital holographic microscopy (dhm) data for hematology applications includes receiving a dhm image acquired using a digital holographic microscopy system and identifying one or more erythrocytes in the dhm image. For each respective erythrocyte included in the one or more erythrocytes, a cell thickness value for the respective erythrocyte using a parametric model is estimated, and a cell volume value is calculated for the respective erythrocyte using the cell thickness value.. ... Siemens Healthcare Diagnostics Inc

Enhanced chloride selective membrane

There is provided a chloride selective membrane including an epoxide-based matrix reacted with a stoichiometric amount of an amino compound and an activator such that the epoxide-based matrix comprising a number of quaternary ammonium groups.. . ... Siemens Healthcare Diagnostics Inc

Methods and kits for determining von willebrand factor activity in the absence of ristocetin

Described herein are method(s), kit(s), reagent(s) and the like for determining von willebrand factor (vwf) activity in a sample in the absence of ristocetin.. . ... Siemens Healthcare Diagnostics Inc

Preparation of lipemic plasma or serum samples for the determination of a lipid interference

The present invention is in the field of in vitro diagnostics and relates to a method for preparing lipemic plasma or serum samples and the use thereof for establishing a lipid interference in the quantitative determination of the amount or the activity of an analyte in a plasma or serum sample.. . ... Siemens Healthcare Diagnostics Inc

Image-based tube slot circle detection for a vision system

Embodiments provide a method of using image-based tube top circle detection that includes extracting, from one of a series of images of a tube tray, a region of interest (roi) patch having a target tube top circle and boundaries constrained by two dimensional (2d) projections of different types of tube top circle centers. The method also includes calculating an edge gradient magnitude map of the roi patch and constructing a three dimensional (3d) map of a circle parameter space, each location in the 3d map corresponding to a circle parameter having a center location and a diameter. ... Siemens Healthcare Diagnostics Inc

Classification of barcode tag conditions from top view sample tube images for laboratory automation

Embodiments are directed to classifying barcode tag conditions on sample tubes from top view images to streamline sample tube handling in advanced clinical laboratory automation systems. The classification of barcode tag conditions leads to the automatic detection of problematic barcode tags, allowing for a user to take necessary steps to fix the problematic barcode tags. ... Siemens Healthcare Diagnostics Inc

Shutter assembly for a luminescence-based sample analyzer

A shutter assembly includes a first shutter blade having a first toothed arm extending therefrom and a first light transmitting aperture therein, and a second shutter blade positioned adjacent and parallel to the first shutter blade. The second shutter blade has a second toothed arm extending therefrom and a second light transmitting aperture therein. ... Siemens Healthcare Diagnostics Inc

Image-based tray alignment and tube slot localization in a vision system

A method of tube slot localization is provided using a tray coordinate system and a camera coordinate system. The method includes receiving, a series of images from at least one camera of a tray comprising tube slots arranged in a matrix of rows and columns. ... Siemens Healthcare Diagnostics Inc

Quantitation of functional groups on solid supports

Processes for quantifying an amount of functional groups immobilized on a solid support are described herein. The processes allow for determining whether sufficient functional groups are provided on a solid support for the attachment of a first binding pair member for the detection of a target analyte.. ... Siemens Healthcare Diagnostics Inc

Model-based methods and apparatus for classifying an interferent in specimens

A model-based method of inspecting a specimen for presence of one or more interferent, such as hemolysis, icterus, and/or lipemia (hi l) is provided. The method includes generating a pixelated image of the specimen in a first color space, determining color components (e.g., an a-value and a b-value) for pixels in the pixelated image, classifying of the pixels as being either liquid or non-liquid, defining one or more liquid regions based upon the pixels classified as liquid, and determining a presence of one or more interferent within the one or more liquid regions. ... Siemens Healthcare Diagnostics Inc

Pipette components useful for medical diagnostics

A pipette is described having a tube, a pressure mechanism, and at least one reagent pad. The tube has a first end, a second end opposite the first end, and a sidewall extending between the first end and the second end, with the sidewall defining an interior cavity. ... Siemens Healthcare Diagnostics Inc

Method for optically determining at least one analyte in a sample

The present invention relates to a method for optically determining at least one analyte in a sample, in which a deviation from a reference value or the reference curve is evaluated as an indication that the optical determination of the at least one analyte is corrupted by measurement artifacts.. . ... Siemens Healthcare Diagnostics Inc

Locality-based detection of tray slot types and tube types in a vision system

A method for detecting properties of sample tubes is provided that includes extracting image patches substantially centered on a tube slot of a tray or a tube top in a slot. For each image patch, the method may include assigning a first location group defining whether the image patch is an image center, a corner of an image or a middle edge of an image, selecting a trained classifier based on the first location group and determining whether each tube slot contains a tube. ... Siemens Healthcare Diagnostics Inc

01/25/18 / #20180024088

Improved magnesium ion selective membranes

The present invention is directed to membranes, sensors, systems and process for the detection of magnesium ions in protein-containing samples. The novel membranes, sensors, systems, and processes are based upon the discovery that the lipophilcity of the plasticizer (or blend of plasticizers) utilized in the formulation of magnesium ion selective membranes for clinical use is inversely proportional to the sensitivity of the plasticizer(s) and directly proportional to the use life thereof.. ... Siemens Healthcare Diagnostics Inc

01/25/18 / #20180021820

Pipette cleaning methods and apparatus, neutralizing liquid vessels, and methods of reducing carryover

Methods and apparatus configured and adapted to provide less carryover in an automated clinical analyzer are disclosed. The methods include immersing a pipette into a neutralizing liquid vessel and aspirating a neutralizing liquid (e.g., a hypochlorite solution) into an interior of a pipette. ... Siemens Healthcare Diagnostics Inc

01/11/18 / #20180011119

Transport of liquid containers in an automated analyzer

The invention relates to a device and a method for the transfer of a liquid container with the aid of a clamping gripper in an automated analyzer. For this purpose, the clamping gripper has a controllable expansion device.. ... Siemens Healthcare Diagnostics Inc

01/04/18 / #20180003731

Method for monitoring sliding contacts

The invention relates to a measuring system for measuring a sample in an automated analysis machine. The measuring system comprises a measuring device for recording measurement values of a measured variable and a first controller and a second controller for processing the measurement values and a sliding contact system with sliding contacts, wherein the measurement values are transferred from the measuring device to the first controller and wherein the measurement values are transferred from the first controller to the second controller via the sliding contacts. ... Siemens Healthcare Diagnostics Inc

12/28/17 / #20170372939

Sensor array with anti-diffusion region(s) to extend shelf life

The inventive concepts disclosed herein are generally directed to a sensor array device that has a prolonged shelf life but requires only a minimal amount of sample volume in order to test two or more analytes concurrently. In order to ensure the sensor array has a sufficient shelf life, anti-diffusion regions are positioned among the reaction wells in order to slow the processes of diffusion. ... Siemens Healthcare Diagnostics Inc

12/28/17 / #20170370904

Hemolysis detection using intracellular analyte concentrations

This disclosure relates to the detection of whole blood hemolysis in a sample of whole blood. More specifically, this disclosure describes detecting hemolysis using one or more novel ratios of intercellular concentrations of whole blood analytes.. ... Siemens Healthcare Diagnostics Inc

12/28/17 / #20170370900

Methods and systems for improving precision of measurements for reduced sample volumes

There is described a process for improving precision in an analytical test for a target analyte in a sample. The process includes prior to analyzing the sample for a target analyte via a biosensor, introducing to an analytical zone defined by the biosensor fluid comprising an effective amount of the target analyte.. ... Siemens Healthcare Diagnostics Inc

12/28/17 / #20170369544

Proteolytic digestion of cardiac troponin i

A fluid sample container comprising a protease, when a sample fluid is placed in the fluid sample container the protease breaking a target analyte in the sample fluid into at least two peptides, the at least two peptides being smaller than the original target analyte.. . ... Siemens Healthcare Diagnostics Inc

12/28/17 / #20170368171

Diagnostics and therapeutics for diseases associated with g-protein coupled receptor adipor2 (adipor2)

The invention provides human adipor2 which is associated with the cardiovascular diseases, dermatological diseases, gastroenterological diseases, cancer, hematological diseases, respiratory diseases, inflammation, neurological diseases, urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, dermatological diseases, gastroenterological diseases, cancer, hematological diseases, respiratory diseases, inflammation, neurological diseases, urological diseases. ... Siemens Healthcare Diagnostics Inc

12/21/17 / #20170362579

Conjugates for assays for oxycodone and oxymorphone

Compositions, methods, and kits are disclosed directed at haptens, immunogens and immunoassays for oxycodone and metabolites thereof. The compounds are exemplified by compounds of the formula i. ... Siemens Healthcare Diagnostics Inc

12/21/17 / #20170362305

Sandwich assay design for small molecules

Methods are disclosed of designing antibodies for a sandwich assay for a small molecule having a molecular weight of about 500 to about 2,000. The method comprises preparing a first antibody that binds to the small molecule, and preparing a second antibody that binds to the small molecule at a portion of the small molecule other than a portion to which the first antibody binds. ... Siemens Healthcare Diagnostics Inc

12/14/17 / #20170356922

Accurate assay measurement of hydrophobic haptenic analytes

Methods are disclosed for determining an actual concentration of a hydrophobic haptenic analyte in an unknown sample suspected of containing the hydrophobic haptenic analyte, wherein the unknown sample is suspected of containing an interfering substance. A first assay method is conducted on an unknown sample to obtain a measured concentration of the hydrophobic haptenic analyte in the unknown sample. ... Siemens Healthcare Diagnostics Inc

11/09/17 / #20170320830

Hydrophilic high quantum yield acridinium esters with improved stability and fast light emission

Hydrophilic, high quantum yield, chemiluminescent acridinium compounds with increased light output, improved stability, fast light emission and decreased non specific binding are disclosed. The chemiluminescent acridinium esters possess hydrophilic, branched, electron-donating functional groups at the c2 and/or c7 positions of the acridinium nucleus.. ... Siemens Healthcare Diagnostics Inc

09/21/17 / #20170269111

Warning system for potentially erroneous measurement results in an automated analyzer

The present invention lies in the field of automated analyzers and relates to an automated warning system for potentially erroneous measurement results, which may be caused by the loss of a liquid container during a transport process.. . ... Siemens Healthcare Diagnostics Inc

09/14/17 / #20170261525

Method for mixing a liquid in an automated analyzer

The present invention lies in the field of automated analyzers and relates to a method for mixing liquids in liquid containers. The arrangement for automated mixing comprises a shaking device and a gripper which is connected by way of a flexible connecting element to a transfer arm and which serves for receiving a liquid container. ... Siemens Healthcare Diagnostics Inc

08/31/17 / #20170248618

Hemolysis detection device, system and method

Aspects of the present invention are directed to devices, systems and methods that enable the quick and reliable detection of hemolysis in a sample such that a sample which exhibits an unacceptable level of hemolysis can be flagged or disregarded in an associated diagnostic test.. . ... Siemens Healthcare Diagnostics Inc

08/31/17 / #20170247753

Method of normalizing biological samples

The present disclosure relates to normalization of biological samples, particularly samples comprising nucleic acids to be sequenced. The normalization protocols described herein may be utilized across multiple samples to cap total stoichiometric input and minimize variations in transcript abundance on a per-sample basis in a multiplexed fashion to dramatically increase the accuracy, capacity and efficiency of nucleic acid sequencing.. ... Siemens Healthcare Diagnostics Inc

08/31/17 / #20170247736

Creatinine biosensor and method of using the same

This disclosure relates to creatinine biosensors and the uses thereof. More specifically, this disclosure describes potentiometric creatinine sensors which utilizes one or both of a type of enzyme capable of directly producing ammonium ions (nh4+) as a consequence of coming into contact with a liquid sample and an internal fill solution with a low free ammonium ion concentration.. ... Siemens Healthcare Diagnostics Inc

08/31/17 / #20170246627

Diagnostic devices with modifiable hydrophobic surfaces

A diagnostic device 10 for screening for a target analyte in a sample is provided. The diagnostic device 10 comprises a substrate 12 and a hydrophobic material 20 disposed on the substrate. ... Siemens Healthcare Diagnostics Inc

08/31/17 / #20170246601

Phase-modulated standing wave mixing apparatus and methods

Disclosed are mixing apparatus adapted to provide mixing of components in an automated analyzer. The mixing apparatus includes a reservoir configured to contain a coupling liquid, a transducer configured to be driven at a frequency and communicate with the coupling liquid, and a signal generation unit configured to provide a phase modulatable drive signal to the transducer. ... Siemens Healthcare Diagnostics Inc

08/24/17 / #20170242047

Pipetting device

The invention relates to a pipetting device (1) for an automatic analysis appliance, wherein the pipetting device (1) comprises a pipetting needle (2) with a longitudinal axis (3), and a device (4) for moving the pipetting needle (2). The pipetting device (1) further comprises a holder (5) for the pipetting needle (2), which holder (5) is mounted on the movable device (4) and to which holder the pipetting needle (2) is releasably connected, and a vibration generator which can set at least the tip of the pipetting needle (2) in vibration, wherein the vibration generator is mounted on the movable device (4).. ... Siemens Healthcare Diagnostics Inc

08/24/17 / #20170241977

Vacuum-assisted plasma separation

A plasma separation system and process for providing filtered plasma from a blood sample is described. The system may include a blood separation well having a separation membrane for filtering the blood sample. ... Siemens Healthcare Diagnostics Inc

08/17/17 / #20170234794

Light and shutter for a sample analyzer

A sample analyzer has a support for an assay sample vessel, a detector, and a shutter assembly. The assay sample vessel contains an assay sample within an assay sample reservoir. ... Siemens Healthcare Diagnostics Inc

08/10/17 / #20170227565

Method for operating an automated analysis machine

The invention relates to a method for transferring a first sample liquid from a first primary vessel into a first target vessel and a second sample liquid from a second primary vessel into a second target vessel with the aid of at least one automated pipetting apparatus comprising a system liquid in an automated analysis machine comprising a control machine.. . ... Siemens Healthcare Diagnostics Inc

08/03/17 / #20170218432

Random access system and method for polymerase chain reaction testing

A random access, high-throughput system and method for preparing a biological sample for polymerase chain reaction (pcr) testing are disclosed. The system includes a nucleic acid isolation/purification apparatus and a pcr apparatus. ... Siemens Healthcare Diagnostics Inc

07/27/17 / #20170210007

Adjustment system

A method for adjusting a transfer apparatus fastened to a robotically displaceable transfer arm and comprising a holder for a liquid vessel in an automated analysis machine, by way of measuring a first and second force effect on the holder with the aid of a sensor, wherein, if the measured force effects do not deviate from one another by more than a predetermined amount, the transfer apparatus is sufficiently adjusted in respect of a receiving position, and wherein, if the measured force effects deviate from one another by more than a predetermined amount, an adjustment of the transfer apparatus in respect of the receiving position is carried out.. . ... Siemens Healthcare Diagnostics Inc

07/20/17 / #20170204849

Method for checking the functionality of a metering pump

The invention relates to a metering pump, for example, for a pipetting apparatus in an automated analysis machine, and to a method for checking the functionality thereof.. . ... Siemens Healthcare Diagnostics Inc

07/20/17 / #20170203294

Low sample volume sensing device

In one aspect, the inventive concepts disclosed herein are directed to a sensor assembly which contains a first planar substrate and a second planar substrate which respectively support opposing sensor arrays and contains an integrated flow path extending between the first and second substrates. Sensor assembly contains a first planar substrate having a base layer, and a conductive layer formed on a first planar surface of the base layer. ... Siemens Healthcare Diagnostics Inc

07/13/17 / #20170197212

Microfluidic test cartridge with no active fluid control

A microfluidic test device and analyzer, the test device includes a sample well, at least one reaction well and a calibrator well fluidicly connected to a waste well which in turn is connected to a pump port. When vacuum pressure from the analyzer is applied through the pump port, fluid from the reaction well and the calibrator well are moved to the waste well via transparent flow paths. ... Siemens Healthcare Diagnostics Inc

06/29/17 / #20170184532

Sensor array

In one illustrative embodiment, a test strip with a first planar substrate has coplanar electrodes on a first planar surface and a second planar substrate (which opposes the first surface of the first planar substrate) has coplanar electrodes on a second planar surface. The first planar surface of the first planar substrate having a first sensing area electrically connected to a first electrical contact. ... Siemens Healthcare Diagnostics Inc

06/22/17 / #20170176419

Luminescent oxygen channeling immunoassay utilizing three antibodies and methods of production and use thereof

A chemiluminescent detection system, as well as kits and microfluidics devices containing same, are disclosed. Methods of using the system, kits, and devices are also disclosed. ... Siemens Healthcare Diagnostics Inc

06/22/17 / #20170175162

Method for detecting a plasmodium infection

The invention relates to a method for detecting a plasmodium infection in a patient blood sample, wherein a differential analysis of the polymorphonuclear neutrophil granulocytes in the sample is performed, and the distribution of the cell volume and the cell density, the number of thrombocytes in the sample, and the distribution of the cell density of the thrombocytes in the sample is determined.. . ... Siemens Healthcare Diagnostics Inc

06/22/17 / #20170173801

Robotic pick and place device with combined gripping and rotational functionality

A pick and place device for use in an in vitro diagnostics automation system is provided that includes a motor and a rotatable motor shaft coupled to the motor and a gripping assembly. The gripping assembly includes a yoke selectively coupled to the rotatable motor shaft and configured to rotate with the rotatable motor shaft when the yoke is coupled to the rotatable motor shaft. ... Siemens Healthcare Diagnostics Inc

06/15/17 / #20170168076

Binding partners specific for vitamin d epimers in vitamin d assays

Methods include determining an amount of vitamin d analyte in a sample suspected of containing the vitamin d analyte. A combination is provided in an assay medium that includes the sample, a vitamin d epimer antibody that is specific for epimers of the vitamin d analyte wherein the vitamin d epimer antibody does not bind to any detectable degree to the vitamin d analyte, and a vitamin d antibody that is specific for the vitamin d analyte, and. ... Siemens Healthcare Diagnostics Inc

06/15/17 / #20170168006

Reader device and method of signal amplification

Fluid collection devices, analysis instruments and methods for making and using same are disclosed. The fluid collection device is provided with a device and an electrochemical cell. ... Siemens Healthcare Diagnostics Inc

06/08/17 / #20170160297

Waste ramp for reagent cards

An automated analyzer for reagent cards having a leading end, a trailing end and a length between the leading end and the trailing end comprises a travel surface assembly having a card travel surface and an edge. A test analyzing mechanism is adjacent to the travel surface, and a waste receptacle is adjacent to the edge below the travel surface. ... Siemens Healthcare Diagnostics Inc

06/08/17 / #20170160295

Methods and reagents for determining isomeric analytes

Methods include determining in a sample an amount of a first isomeric analyte and a second isomeric analyte. A first measurement value and a second measurement value are determined. ... Siemens Healthcare Diagnostics Inc

06/08/17 / #20170159043

Magnetic particles with a closed ultrathin silica layer, method for the production thereof and their use

A method for producing silicate-containing magnetic particles having a closed and tight silicate layer and high purity. In addition, the novel method prevents an uncontrolled formation of aggregates and clusters of silicates on the magnetite surface, thereby having a positive influence on the properties and biological applications. ... Siemens Healthcare Diagnostics Inc

06/01/17 / #20170153254

Assays for vitamin d epimers

Methods include determining an amount of an epimeric vitamin d analyte in a sample suspected of containing the epimeric vitamin d analyte. A combination is provided in an assay medium that includes the sample and a vitamin d epimer antibody that is specific for the epimeric vitamin d analyte. ... Siemens Healthcare Diagnostics Inc

06/01/17 / #20170153241

Cell response assay for cancer and methods of producing and using same

A cell response assay for cancer is provided. In the assay, the levels of a cancer cell type biomarker, a chemo resistance biomarker and a metastatic potential biomarker are simultaneously measured in a biological sample.. ... Siemens Healthcare Diagnostics Inc

05/18/17 / #20170137901

Reagents and methods for detecting hcv

The present disclosure relates to oligonucleotide sequences for amplification primers and their use in performing nucleic acid amplifications of hcv, in particular regions that encode the ns3 polypeptide. In some embodiments the primers are used in nested pcr methods for the detection or sequencing of hcv ns3. ... Siemens Healthcare Diagnostics Inc

05/18/17 / #20170137894

Oligonucleotides and methods for detecting kras and pik3ca mutations

Provided are oligonucleotides that are capable of detecting kras and pik3ca mutations in both cancer patients and healthy individuals with high specificity in kpcr assays. When the oligonucleotides are used as forward primers in conjunction with a defined genotyping algorithm spreadsheet, the primers are capable of enhancing detection of kras codon 12, 13, and 61 and pik3ca codon 542, 545, and 1047 single nucleotide polymorphisms (snps) in a background of wild-type sequences. ... Siemens Healthcare Diagnostics Inc

05/18/17 / #20170137805

Selective nucleic acid separation

Nucleic acids in non-rare cells in a sample containing non-rare cells and rare cells are selectively released from the non-rare cells. The sample is combined with an aqueous medium, and the combination is held for a period of time and at a temperature for selectively releasing nucleic acids from the non-rare cells but not from the rare cells. ... Siemens Healthcare Diagnostics Inc

05/11/17 / #20170132450

Analyzing digital holographic microscopy data for hematology applications

A method for analyzing digital holographic microscopy (dhm) data for hematology applications includes receiving a plurality of dhm images acquired using a digital holographic microscopy system. One or more connected components are identified in each of the plurality of dhm images and one or more training white blood cell images are generated from the one or more connected components. ... Siemens Healthcare Diagnostics Inc

05/04/17 / #20170124704

Drawer vision system

Methods and systems for detecting properties of sample tubes in a laboratory environment include a drawer vision system that can be trained and calibrated. Images of a tube tray captured by at least one camera are analyzed to extract image patches that allow a processor to automatically determine if a tube slot is occupied, if the tube has a cap, and if the tube has a tube top cup. ... Siemens Healthcare Diagnostics Inc

05/04/17 / #20170122901

Reagents for potentiometric magnesium ion selective electrode sensors and methods of production and use thereof

Reagents are disclosed for use with potentiometric magnesium ion selective electrodes, along with kits containing same as well as methods of use thereof. Before explaining at least one embodiment of the inventive concept(s) in detail by way of exemplary drawings, experimentation, results, and laboratory procedures, it is to be understood that the inventive concept(s) is not limited in its application to the details of construction and the arrangement of the components set forth in the following description or illustrated in the drawings, experimentation and/or results.. ... Siemens Healthcare Diagnostics Inc

05/04/17 / #20170121539

Method for increasing the scratch resistance of plastic cuvettes

The present invention relates to the field of consumable materials for automatic analytical instruments and relates to a method for producing plastic cuvettes with increased scratch resistance.. . ... Siemens Healthcare Diagnostics Inc

05/04/17 / #20170121426

Binding partners specific for vitamin d epimers

Antibodies are raised against compounds of formula (i) where z is an immunogenic carrier. These compounds are capable of binding specifically to corresponding antibodies. ... Siemens Healthcare Diagnostics Inc

05/04/17 / #20170120164

Fluidic device and degassing method

A fluidic device and a method for degassing a fluidic device are presented. The fluidic device includes a plurality of fluidic components such as channels, chambers, and integrated valves and pumps, etc. ... Siemens Healthcare Diagnostics Inc

04/27/17 / #20170114012

Compositions relating to vitamin d

This invention relates to compositions, methods and kits for determining the presence and/or amount of vitamin d analytes, including vitamin d isomers, and metabolites thereof in a sample suspected of containing the same. Compounds include compounds of the formula i, namely, (r1)p-(l)q-z wherein r1, l, p and q are as defined herein. ... Siemens Healthcare Diagnostics Inc

04/27/17 / #20170113217

Sample delivery system

Inventive concepts disclosed herein are directed to a capillary tube and a force assisted sample ejection mechanism. The capillary tube may be at least one of dissolvable or breakable. ... Siemens Healthcare Diagnostics Inc

04/20/17 / #20170108516

Detection of hemolysis using a chromatographic detection pad

In one aspect, the inventive concepts disclosed herein are directed to a chromatographic assay device for detecting the presence of free hemoglobin in a whole blood sample. The device comprising a chromatographic detection pad with a sample application site and a detection side. ... Siemens Healthcare Diagnostics Inc

04/13/17 / #20170102390

Rare molecule detection

A concentrated sample having enhanced concentration of the one or more different populations of target rare molecules is incubated with, for each different population of target rare molecules, a particulate or non-particulate affinity agent that comprises a specific binding partner that is specific for and binds to a target rare molecule. The affinity agent comprises a mass spectrometry (ms) label precursor or a first alteration agent, which either facilitates the formation of an ms label from the ms label precursor or releases an entity that comprises the ms label precursor from the affinity agent. ... Siemens Healthcare Diagnostics Inc

03/23/17 / #20170082646

Method and apparatus for reducing carryover of reagents and samples in analytical testing

A method of reducing carryover of liquids, such as reagent and/or samples, in analytical or immunoassay testing. The method includes providing an incubation member including a plurality of reaction vessels thereon, pre-assigning certain ones of the reaction vessels in the incubation member for only first test types or certain reagent types for all test lots; and pre-assigning other ones of a second subset of reaction vessels in the incubation member for only second test types for all test lots. ... Siemens Healthcare Diagnostics Inc

02/23/17 / #20170053400

Method and apparatus for processing block to be processed of urine sediment image

Concepts herein relate to processing urine sediment images. An example method comprises: approximating the color of a pixel in a block to be processed to one of the kc colors in a code book, wherein the code book is a set of the kc colors generated in a set of urine sample blocks; obtaining a distribution histogram of the number of pixels the color approximation results of which fall on each color of the kc colors; using an occurrence frequency correction factor to correct the number of pixels the color approximation results; standardizing the corrected number of pixels the color approximation results; and processing the block to be processed.. ... Siemens Healthcare Diagnostics Inc

02/23/17 / #20170053399

Method and apparatus for processing block to be processed of urine sediment image

Provided in the present invention are a method and apparatus for processing a block to be processed of a urine sediment image. The method comprises: calculating a variable number of local feature vectors of a block to be processed, wherein the local feature vector is a vector representing a feature of a local location of the block to be processed; classifying the variable number of local feature vectors into a fixed number of clusters so as to obtain a statistical histogram vector of the fixed number of clusters of the block to be processed, wherein the statistical histogram vector reflects the statistical distribution of the variable number of local feature vectors in the fixed number of clusters; and taking the statistical histogram vector as a feature in a feature set of block processing and processing the block to be processed.. ... Siemens Healthcare Diagnostics Inc

02/16/17 / #20170046838

Method and apparatus for processing block to be processed of urine sediment image

In the present invention are a method and apparatus for processing a block to be processed of a urine sediment image. The method comprises: dividing a block to be processed into a plurality of grids; calculating an n-dimensional local feature vector of each grid of the plurality of grids, where n is a positive integer; in the block to be processed, merging at least two adjacent grids of the plurality of grids into an intermediate block; calculating an intermediate block merging feature vector of the intermediate block; according to a predetermined combination rule, combining the intermediate block merging feature vectors obtained for different intermediate blocks of the block to be processed into a general combination feature vector of the block to be processed; and by way of taking the general combination feature vector as a feature in a feature set of block processing, processing the block to be processed.. ... Siemens Healthcare Diagnostics Inc

02/16/17 / #20170046621

Method and apparatus for performing block retrieval on block to be processed of urine sediment image

The inventive concepts herein relate to performing block retrieval on a block to be processed of a urine sediment image. The method comprises: using a plurality of decision trees to perform block retrieval on the block to be processed, wherein each of the plurality of decision trees comprises a judgment node and a leaf node, and the judgment node judges the block to be processed to make it reach the leaf node by using a block retrieval feature in a block retrieval feature set to form a block retrieval result at the leaf node, and at least two decision trees in the plurality of decision trees are different in structures thereof and/or judgments performed by the judgment nodes thereof by using the block retrieval feature; and integrating the block retrieval results of the plurality of decision trees so as to form a final block retrieval result.. ... Siemens Healthcare Diagnostics Inc

02/16/17 / #20170045545

Mother daughter tube carrier for aliquoters

An analyzer for use with in vitro diagnostics includes an automation system to move a plurality of sample carriers within the system. At least some carriers include a plurality of slots. ... Siemens Healthcare Diagnostics Inc

02/16/17 / #20170045544

Pipetting device having two temperature sensors

The invention is in the field of automatic analysis devices and relates to a heatable pipetting device for an automatic analysis device and a method for providing a reaction mixture. The pipetting device comprises a pipetting needle having two temperature sensors at different distances to the tip of the pipetting needle.. ... Siemens Healthcare Diagnostics Inc

02/16/17 / #20170045541

Reaction vessel handling apparatus, testing apparatus, and methods using same

Disclosed is a reaction vessel handling apparatus adapted for use in a biological fluid testing apparatus. The reaction vessel handling apparatus includes an incubation member and wash member that are overlapping. ... Siemens Healthcare Diagnostics Inc

02/16/17 / #20170043341

Microfluidic device

A microfluidic device 10 is provided that includes a porous substrate 12 and a plurality of reaction channels 14 disposed on a first side 36 of the porous substrate 12. The reaction channels 14 are defined by a barrier material 16 disposed on the substrate 12 in a user-defined pattern 13. ... Siemens Healthcare Diagnostics Inc

02/09/17 / #20170038389

Method to screen out false positives in a circulating tumor cell assay

Provided herein are methods of screening a patient sample in a circulating tumor cell assay for false positives as well as methods of performing a circulating tumor cell detection assay. Also provided herein are methods of simultaneously identifying, and methods of distinguishing between, a circulating tumor cell and a circulating endothelial cell in a patient sample. ... Siemens Healthcare Diagnostics Inc

02/09/17 / #20170036204

Sample collection unit

An insert for a sample collection tube includes a generally hollow tubular body insertable into the sample collection tube. The tubular body is open at least at one end. ... Siemens Healthcare Diagnostics Inc

02/02/17 / #20170032091

Intelligent service assistant inference engine

A method of providing dynamic analysis for troubleshooting in vitro diagnostics instrument issues includes receiving, at a second computing device in communication with a plurality of instruments, identification of an issue associated with a portion of an instrument of the plurality of instruments, the identification received from a first computing device in communication with the instrument. A central computing device accesses data from one or more databases and determines an ordering of one or more corrective actions for resolving the issue by applying the data to a probabilistic model based on at least one of: patterns from the plurality of instruments; and operator input. ... Siemens Healthcare Diagnostics Inc

02/02/17 / #20170030932

Spectroscopic methods for the detection of glycated hemoglobin

Kits, microfluidics devices, and assays for use in methods of spectroscopically determining a ratio of glycated hemoglobin to total hemoglobin in a whole blood sample are disclosed.. . ... Siemens Healthcare Diagnostics Inc

02/02/17 / #20170030856

Magnesium sensing membrane for potentiometric ion selective electrode for measuring ionized magnesium and methods of production and use thereof

A magnesium sensing membrane is disclosed for use in a potentiometric ion selective electrode that exhibits improved stability upon exposure to surfactant-containing reagents. Kits containing same are disclosed, along with methods of production and use of the magnesium sensing membrane.. ... Siemens Healthcare Diagnostics Inc

02/02/17 / #20170030821

Urine sediment analysis workstation

A sediment analysis workstation includes an optical microscope, an image recording device connected to an optical unit of the optical microscope and a user interface device connected to the image recording device. The user interface device comprises one or more processors running computer executable instructions that when executed by the one or more processor causes the one or more processor to count particles of a sediment sample based upon a manual input by an operator, and store counted particles of the sediment sample in a memory of the user interface device. ... Siemens Healthcare Diagnostics Inc

01/19/17 / #20170017538

Intelligent service assistant - instrument side software client

A method of providing troubleshooting for an in vitro diagnostics instrument includes receiving, via a computing device, identification of one of a plurality of issues of the instrument, each of the plurality of issues associated with a portion of the instrument. An ordered list of one or more corrective actions to resolve the issue is provided via a user interface in communication with the computing device. ... Siemens Healthcare Diagnostics Inc

01/19/17 / #20170016927

Method for pipetting liquids in an automated analysis apparatus

The present invention lies in the field of automated analysis apparatuses and relates to a method for transferring a liquid volume from a first liquid vessel into a second liquid vessel. The method ensures increased pipetting accuracy, even from liquid vessels (1) which have foam (3) on the surface of the liquid (2).. ... Siemens Healthcare Diagnostics Inc

01/19/17 / #20170016876

Device and method for unit use sensor testing

An analyte testing material web, method of making the analyte testing material web, and an analyzer are disclosed. The analyte testing material web has a material web and a plurality of distinct sample testing devices. ... Siemens Healthcare Diagnostics Inc

01/05/17 / #20170003242

Method for detecting contact of a pipetting needle

The invention relates to a method for detecting contact of a pipetting needle in an in vitro diagnostic system. To this end, the pipetting needle, in an advantageous embodiment of the invention, should be cyclically charged by an electric voltage or current applied between the pipetting needle and a reference potential and discharged again by a subsequent electric connection between the pipetting needle and the reference potential. ... Siemens Healthcare Diagnostics Inc

01/05/17 / #20170002429

Method for detecting an increased risk or incidence of colorectal cancer

The present invention relates to the methods and products for detection of colorectal cancer. Additionally, the present invention relates to methods and products for determining the probability, risk or incidence of colorectal cancer and of colorectal cancer metastasis. ... Siemens Healthcare Diagnostics Inc








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