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The Board Of Regents Of The University Of Texas System
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The Board Of Regents Of The University Of Texas System patents


Recent patent applications related to The Board Of Regents Of The University Of Texas System. The Board Of Regents Of The University Of Texas System is listed as an Agent/Assignee. Note: The Board Of Regents Of The University Of Texas System may have other listings under different names/spellings. We're not affiliated with The Board Of Regents Of The University Of Texas System, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "T" | The Board Of Regents Of The University Of Texas System-related inventors


Metal-ion electrochemical biosensor and use thereof

One aspect of the invention provides a method of determining metal ion levels in the patents due to corrosion and wear processes of the metallic implant in a human or veterinary patient. One embodiment provides a cost effective and patient driven early diagnostic method which has a potential application in... The Board Of Regents Of The University Of Texas System

Prosthetic socket fit sensor

An apparatus for achieving a best possible prosthetic fit in a prosthesis system for an amputee includes a sensor array embedded in a gel like substance slipped over a residual limb in a socket configuration with respect to a prosthesis system. Such an apparatus can also include data collection and... The Board Of Regents Of The University Of Texas System

Tumor-selective combination therapy

The therapies described herein can be selectively lethal toward a variety of different cancer cell types and cancer conditions in a subject. The combination therapies described herein can be useful for the management, treatment, control, or adjunct treatment of diseases, where the selective legality is beneficial in chemotherapeutic therapy, particularly... The Board Of Regents Of The University Of Texas System

Microporous metal-organic frameworks for the removal of acetylene from ethylene

A metal-organic framework (MOF) and uses thereof are provided herein, including MOF comprising a repeat unit of the formula [ML], wherein L is a ligand of the following formula: and M is a divalent metal such as copper. The MOFs provided herein may be used in the separation of two... The Board Of Regents Of The University Of Texas System

Anti-lilrb antibodies and their use in detecting and treating cancer

The present disclosure is directed to antibodies binding to LILRBs and methods of detecting and treating cancer therewith.... The Board Of Regents Of The University Of Texas System

Rapid pertussis diagnosis on a point-of-care hybrid microfluidic biochip

Certain embodiments are directed to a point-of-care (POC) microfluidic biochip for rapid, highly sensitive and specific pertussis diagnosis. The POC biochip can be used in various venues such as physician's office, schools, hospitals, and low-resource settings so that rapid prevention and treatment of pertussis can be achieved. The POC biochip... The Board Of Regents Of The University Of Texas System

Anti-dc-hil antibodies for cancer diagnosis, prognosis and therapy

The present disclosure is directed to antibodies that bind to DC-HIL on the surface of myeloid-derived suppressor cells, and thus antagonize the T cell suppressor function of these cells, as well as their use in diagnosing and treating cancers such as melanoma.... The Board Of Regents Of The University Of Texas System

Her3 specific monoclonal antibodies for diagnostic and therapeutic use

Isolated or recombinant anti-HER3 monoclonal antibodies are provided. In some cases, antibodies of the embodiments can be used for the detection, diagnosis and/or therapeutic treatment of human diseases, such as cancer.... The Board Of Regents Of The University Of Texas System

Iron garnet nanoparticles for cancer radiotherapy and chemotherapy

Iron garnet nanoparticles and or iron garnet particles containing various activatable nuclides, such as holmium-165 (165Ho) and dysprosium-164 (164Dy), are disclosed in this application. The iron garnet (e.g., HoIG and DyIG) nanoparticles and iron garnet particles can prepared using hydroxide co-precipitation methods. In some embodiments, radiosensitizers can be loaded on... The Board Of Regents Of The University Of Texas System

Kub5/hera as a determinant of sensitivity to dna damage

The present disclosure is directed to methods of detecting KUB5/HERA expression levels, copy number and mutation status, particularly in cancer cells. The methods permit physicians to tailor therapies to subject having certain genotypes/phenotypes, and to exclude therapies unlikely to be effective.... The Board Of Regents Of The University Of Texas System

Three-dimensional scaffold culture system of functional pancreatic islets

A cell culture system including a silk fibroid scaffold, culture media, and pancreatic cells. The pancreatic cells grown in the tissue culture system have physiological and morphological features like those of in vivo pancreatic cells. The cell culture system can be used to produce a pancreatic tissue-specific extracellular matrix capable... The Board Of Regents Of The University Of Texas System

Tsp1 as a marker for cancer

The present disclosure is directed to TSP1 and its coding RNA and cDNA as markers for cancer. Diagnostic methods and reagents for performing such assays also are described.... The Board Of Regents Of The University Of Texas System

Glycoconjugate vaccine for leishmaniasis

Certain embodiments are directed to an immunogenic composition comprising an immunogenic glycoconjugate comprising a glycan having the chemical formula of galactopyranose (Galp)-α(1,2)-R, Galp-α(1,3)-R, Galp-α(1,4)-R, or Galp-α(1,6)-R, wherein in R is any monosaccharide, oligosaccharide, or polysaccharide, coupled to a carrier peptide or protein. Certain aspects described herein are directed to compounds... The Board Of Regents Of The University Of Texas System

3d ti-6al-4v structures with hydrogel matrix

Embodiments of the invention are directed to a vascular structure forming implant produced by additive manufactured Ti-6Al-4V foams a living implant.... The Board Of Regents Of The University Of Texas System

Treatment of drug resistant proliferative diseases with telomerase mediated telomere altering compounds

The described invention is directed toward pharmaceutical compositions and methods of using 6-mercaptopurine ribosides and analogues thereof for the treatment of cancer and other hyperproliferative diseases. The described compounds can be converted into telomere substrates in vivo and can be recognized by telomerase for incorporation into telomeres of telomerase active... The Board Of Regents Of The University Of Texas System

Apparatuses and methods for pathogen detection using microfluidic biochips

Certain embodiments are directed to a paper hybrid microfluidic microplate. In certain aspects, the hybrid microfluidic microplate is a low-cost, sensitive, and fast diagnostic apparatus for detecting pathogens, diagnosing disease and other bio-applications, especially for low-resource settings.... The Board Of Regents Of The University Of Texas System

1,3-dipolar [70]fulleropyrrolidinium iodide derivatives

Certain embodiments are directed to C70 fullerene derivatives N-N-dimethyl [70]fulleropyrrolidinium iodide. Certain further embodiments are directed to α, β and γ isomer of N-N-dimethyl[70]fulleropyrrolidinium iodide.... The Board Of Regents Of The University Of Texas System

Small-molecule inhibitors targeting discoidin domain receptor 1 and uses thereof

Compounds of formula (I), their pharmaceutically acceptable salts and stereoisomers thereof, as well as application in effectively inhibiting the enzymatic activity of discoidin domain receptor 1 and can be used as new therapeutic agents for preventing and treating e.g. inflammation, liver fibrosis, kidney fibrosis, lung fibrosis, skin scar, atherosclerosis, and... The Board Of Regents Of The University Of Texas System

Volatile anesthetic compositions comprising extractive solvents for regional anesthesia and/or pain relief

The present invention provides methods for reducing pain in a subject in need of such pain reduction by delivering, e.g., intrathecally or epidurally, a volatile anesthetic dissolved in a solution comprising an extractive solvent, e.g., DMSO or NMP, in an amount effective to reduce pain. Chronic or acute pain may... The Board Of Regents Of The University Of Texas System

Use of mtor inhibitors to prevent and regress edhesions and fibrosis

Embodiments of the disclosure include preventing or reducing adhesion between two tissues and/or organs in an individual subjected to a procedure and/or preventing or reducing one or more keloids in an individual subjected to a procedure by providing to the individual an effective amount of a composition comprising one or... The Board Of Regents Of The University Of Texas System

Small molecules for the treatment of primary cancer and cancer metastasis

Certain embodiments are directed to non-hydrolysable ATP analogs and adenosine receptor antagonists that inhibit migration and growth of cancer cells.... The Board Of Regents Of The University Of Texas System

Systems and imaging devices with angular orientation indications

Exemplary embodiments of the present invention relate generally to the fields for indicating a location on an image in a multi-viewer display. In particular embodiments, the multi-viewer display may be a multi-viewer microscope.... The Board Of Regents Of The University Of Texas System

Oxygen generating biomaterial

Certain embodiments include materials that carry oxygen and emit molecular oxygen upon heating. The approach reported here uses thermal decomposition of organic endoperoxide compounds to produce singlet oxygen. In certain aspects the oxygen carrier comprises an organic compound either alone or contained in a polymeric carrier or other carrier material... The Board Of Regents Of The University Of Texas System

Fkbp52-specific androgen receptor inhibitor, mjc13, for use in treating breast cancer

Embodiments of the current invention include methods and compositions for treating breast cancer by administering an effective amount of MJC13 to a subject in need thereof.... The Board Of Regents Of The University Of Texas System

Downhole induction heater and coupling system for oil and gas wells

Described herein are methods and system that use electromagnetic heating to heat wellbores and the fluids therein. The heating is achieved by placing one or more permanent magnets in the wellbore and moving a metallic component and/or the one or more permanent magnets relative to each other. This generates eddy... The Board Of Regents Of The University Of Texas System

Compositions for the delivery of trna as nanoparticles and methods of use therewith

In some aspects, the present disclosure provides a nanoparticle composition comprising tRNA and an aminolipid delivery compound. The aminolipid delivery compound may be a dendrimer, dendron, or dendritic lipid, a polymer such as a polyamide or polyester, or a lipid with one or more hydrophobic components. In some embodiments, these... The Board Of Regents Of The University Of Texas System

Cationic sulfonamide amino lipids and amphiphilic zwitterionic amino lipids

wherein the variables are as defined herein. These amino lipids may be used in compositions with one or more helper lipids and a nucleic acid therapeutic agent. These compositions may be used to treat a disease or disorder such as cancer, cystic fibrosis, or other genetic diseases.... The Board Of Regents Of The University Of Texas System

Antiparasitic compositions and methods utilizing substituted 5,5,7,7-tetramethyl-4,5,6,7-tetrahydrothieno[2,3-c] pyridine derivatives

where X, R1, R2, R3, R4, R5, and R6 are defined more fully below.... The Board Of Regents Of The University Of Texas System

Method and use of ceramic/carbon composite nanofibers as an anode for lithium-ion and sodium-ion batteries

Tin-containing carbon fibers may be produced by centrifugal spinning of a precursor composition that includes a base polymer and a tin-containing compound. The produced fibers are heated at a temperature sufficient to convert at least a portion of the base polymer in the collected fibers into carbon fibers comprising tin.... The Board Of Regents Of The University Of Texas System

Utsa-74: a metal organic framework with two accessible binding sites per metal center for gas separation and gas storage

The MOFs provided herein may be used in the separation of two or more gaseous molecules from each other. In some embodiments, the gaseous molecules are carbon dioxide and acetylene.... The Board Of Regents Of The University Of Texas System

Xrn2 as a determinant of sensitivity to dna damage

The present disclosure is directed to methods of detecting XRN2 expression levels, copy number and mutation status, particularly in cancer cells. The methods permit physicians to tailor therapies to subject having certain genotypes/phenotypes, and to exclude therapies unlikely to be effective.... The Board Of Regents Of The University Of Texas System

Attenuated burkholderia mallei strain which protects against pathogenic burkholderia infections, vaccine containing and use thereof

Herein we describe construction of a select agent-excluded B. mallei ΔtonB Δhcp1 (CLH001) vaccine strain and demonstrate its ability to protect against acute respiratory glanders. Particularly, CLH001 is shown to be attenuated, safe, and effective at protecting against lethal B. mallei challenge. This strain should be useful in vaccines are... The Board Of Regents Of The University Of Texas System

Glycoconjugates and methods for their use

Certain embodiments are directed to method for synthesizing and using glycoconjugates on the immunodominant epitope Galα(1,3)Galβ(3(1,4)GlcNAcα (Galα3LNα).... The Board Of Regents Of The University Of Texas System

Stat line central line medical kit

Certain embodiments are directed to materials and devices to be used in conjuction with interventional medical procedures. In certain aspects the interventional procedure is ultrasound guided venous cathterization.... The Board Of Regents Of The University Of Texas System

Methods and compositions for enhancing chemotherapy

Embodiments of the invention are directed to methods and compositions using low dose sorafenib to enhance a cancer therapy.... The Board Of Regents Of The University Of Texas System

11/16/17 / #20170326370

Systems and methods for switched electrode stimulation for low power bioelectronics

Systems and methods for stimulating tissue. Exemplary embodiments include systems and methods configured to maintain one electrode at a fixed voltage potential and switching a second electrode between different fixed voltage potentials.... The Board Of Regents Of The University Of Texas System

11/09/17 / #20170320993

Novel block copolymer and micelle compositions and methods of use thereof

wherein R′ is —H or —CH3, wherein R is —NR1R2, wherein R1 and R2 are alkyl groups, wherein R1 and R2 are the same or different, wherein R1 and R2 together have from 5 to 16 carbons, wherein R1 and R2 may optionally join to form a ring, wherein n... The Board Of Regents Of The University Of Texas System

11/02/17 / #20170311827

Microchannel scaffolds and microtube electrodes for a neural interface system

Neural interfaces with the peripheral nervous system have been developed to provide a direct communication pathway between peripheral nerves and prosthetic limbs. Described herein is a microchannel integrated neural network device and system which can control the reinnervated muscles and interpret neurological signals. The acquired bioelectrical signals can be used... The Board Of Regents Of The University Of Texas System

11/02/17 / #20170312318

Methods and compositions for in vivo induction of pancreatic beta cell formation

Embodiments of the invention stimulate three levels of beta cell physiology: (i) glucose metabolism, (ii) membrane receptor function, and (iii) transcriptional factors that result in the in vivo formation of beta cells in the pancreas for the purpose of treating diabetes. In certain aspects, the methods include the integration of... The Board Of Regents Of The University Of Texas System

11/02/17 / #20170313716

Oridonin analogs, compositions, and methods related thereto

Certain embodiments are directed to oridonin analogs or derivatives. In certain aspects, the derivatives are used as anticancer or anti-inflammatory agents.... The Board Of Regents Of The University Of Texas System

11/02/17 / #20170313739

Taccalonolide microtubule stabilizers

The invention provides epoxytaccalonolide microtubule stabilizers and their use as anti-proliferative microtubule stabilizing agents.... The Board Of Regents Of The University Of Texas System

11/02/17 / #20170316179

Systems and methods for prescribed exercise monitoring

Systems and methods for monitoring performance of prescribed exercises. Particular embodiments allow clinicians and other exercise experts the ability to qualitatively and quantitatively follow compliance outside of subjective reporting, of the individual performing the prescribed exercises by accurately assessing range of motion, speed and path efficiency.... The Board Of Regents Of The University Of Texas System

10/26/17 / #20170303848

Infravein vasculature visualization device

Embodiments of the devices described herein are directed to a vein imaging system which adds user protection, variable positioning, and portability to an established imaging modality, near infrared (NIR) videography and videogrammetry.... The Board Of Regents Of The University Of Texas System

10/26/17 / #20170304240

Novel compounds supports hematopoietic stem cells and red blood cells

The present disclosure relates to methods of using a compound to induce regeneration of hematopoietic stem cells or increase the recovery of red blood cells. In some aspects, the present methods can be used to with or in place of erythropoietin in patients to mitigate the side effects of erythropoietin.... The Board Of Regents Of The University Of Texas System

10/26/17 / #20170304300

Hif-2alpha inhibitors for treating iron overload disorders

The present disclosure relates to HIF-2α inhibitors and methods of making and using them for treating iron overload disorders. Certain compounds were potent in HIF-2α scintillation proximity assay, luciferase assay, and VEGF ELISA assay, and reduced liver iron accumulation and serum iron parameters in both prophylactic and treatment mouse models.... The Board Of Regents Of The University Of Texas System

10/26/17 / #20170304623

Systems and methods for network based neurostimulation of cognitive processes

This invention relates generally to systems and methods for multifocal direct brain stimulation to enhance cognitive processing, such as but not limited to stimulation-induced modulation of memory.... The Board Of Regents Of The University Of Texas System

10/26/17 / #20170304926

Homopolor generator pulsed welding generator subsystems

Described herein are methods and system for welding, for example, girders. The method may include activating a homopolar generator. The method may include applying a force to two metal girders at a desired coupling joint. The method may include generating an electrical pulse using the homopolar generator and conducting the... The Board Of Regents Of The University Of Texas System

10/19/17 / #20170296644

Methods for treating plague

Provided herein are methods for using compositions that include a fusion protein having a YscF protein domain, a mature F1 protein domain, and a LcrV protein domain. In one embodiment the composition is used to confer immunity to plague, such as pneumonic plague, caused by Yersinia pestis. In one embodiment,... The Board Of Regents Of The University Of Texas System

10/19/17 / #20170298107

Use of a small native peptide activator of serca pump for treatment of heart failure and other disorders characterized by cytosolic calcium overload

The present disclosure describes a new native peptide designated herein as Dwarf Open Reading Frame, or DWORF. This peptide enhances the apparent activity of the SERCA pump, is positively inotropic and lusitropic, and therefore is provided as a therapeutic agent for disorders characterized by cytosolic calcium overload.... The Board Of Regents Of The University Of Texas System

10/05/17 / #20170281578

Methods for treating metabolic disturbances

In some aspects, the present invention provides a composition comprising a powder or mixture comprising from about 10 meq to 50 meq of potassium, 5 meq to 25 meq of magnesium, and from about 18 meq to 90 meq of citrate and uses of the same to prevent or treat... The Board Of Regents Of The University Of Texas System

10/05/17 / #20170281600

Intravenous formulation and lc/ms/ms analysis gmc1

Certain embodiments are directed to a GMC1 co-solvent formulation. The GMC1 co-solvent formulation described herein can be used for the treatment of prostate cancer, benign prostatic hypertrophy, and other hormone-related conditions involving androgen, glucocorticoid, and progesterone receptors.... The Board Of Regents Of The University Of Texas System

09/28/17 / #20170275280

Novel capsazepine analogs for the treatment of cancer and other proliferative diseases

The present disclosure relates generally to derivatives of capsazepine and methods of use thereof In some aspects, the present disclosure relates to using capsazepine derivatives to treat cancer or other hyperproliferative diseases. In some aspects of the present disclosure, the disclosure provides capsazepine derivatives which may be useful in the... The Board Of Regents Of The University Of Texas System

09/28/17 / #20170276599

Cost effective battery-powered spectrophotometric system

Certain embodiments are directed to a low-cost battery-powered spectrophotometric system (BASS) coupled with a microfluidic chip for POC analysis, as well as methods of using the same.... The Board Of Regents Of The University Of Texas System

09/07/17 / #20170252380

Devices and methods for umbilical cord processing

Devices and methods for extraction and processing of substantia gelatinea funiculi umbilicalis (Wharton's Jelly) from an umbilical cord. Isolated pluripotent cell compositions and methods of using the same are also provided.... The Board Of Regents Of The University Of Texas System

08/24/17 / #20170240919

Attenuated recombinant alphaviruses incapable of replicating in mosquitoes and uses thereof

The present invention discloses an attenuated recombinant alphavirus that is incapable of replicating in mosquito cells and of transmission by mosquito vectors. These attenuated alphavirus may include but is not limited to Western Equine Encephalitis virus, Eastern equine encephalitis virus, Venezuelan equine encephalitis virus or Chikungunya virus. The present invention... The Board Of Regents Of The University Of Texas System

08/17/17 / #20170233699

Tissue-specific differentiation matrices and uses thereof

In some aspects, this invention provides a method of making a bone marrow-derived tissue-specific stem cell proliferation, expansion, isolation and rejuvenation extracellular matrix. In other aspects, this invention provides a method of making a tissue-specific fibroblast-derived stem cell differentiation extracellular matrix. Also provided are methods of using such a cell-derived... The Board Of Regents Of The University Of Texas System

08/17/17 / #20170233735

Allele selective inhibition of mutant c9orf72 foci expression by duplex rnas targeting the expanded hexanucleotide repeat

Provided herein are compositions and methods for reducing expression of C9orf72 transcripts in cells containing expanded intronic GGGGCC regions, including those in subjects having or at risk of developing amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Provided herein are a double-stranded oligonucleotides of 13 to 22 nucleobases in length... The Board Of Regents Of The University Of Texas System

08/17/17 / #20170233792

Fixation single cell analysis

A novel fixation method is presented that will circumvent both biological and safety concerns with current fixation methods.... The Board Of Regents Of The University Of Texas System

08/10/17 / #20170223962

Composition and methods for modulation of the octopamine receptor and its homologs

Embodiments of the invention are directed of compositions for activation or inhibition of the Octβ2 receptor and uses thereof. The inventors have discovered that the beta adrenergic-like octopamine receptor Octβ2 serves as a key signaling molecule for ovulation and recruits protein kinase A and Ca2+/calmodulin-sensitive kinase II as downstream effectors... The Board Of Regents Of The University Of Texas System

08/03/17 / #20170216059

Methods and increasing the proximal movement of blood or lymph

Embodiments are directed to devices configured to assist the flow of fluids in the body. The device comprises a covering for placing on the skin of a patient having protrusions which can contact the skin. The protrusions have a base proximal to a surface of the covering and an outer... The Board Of Regents Of The University Of Texas System

08/03/17 / #20170216323

Methods for treating viral infections using hydrogen sulfide donors

Certain embodiments are directed to methods of treating respiratory infection by administering an H2S donor.... The Board Of Regents Of The University Of Texas System

07/27/17 / #20170209526

Novel peptide inhibitors of serotonin 5-ht2c receptor:pten interaction

The inventors have identified how the assembly of the 5-HT2cR with another protein (phosphatase and tensin homologue; PTEN) controls cellular function, and have synthesized a new peptide that interrupts the 5-HT2cR:PTEN complex to result in enhanced 5-HT2cR function.... The Board Of Regents Of The University Of Texas System

07/27/17 / #20170211050

T7 rna polymerase variants with expanded substrate range and enhanced transcriptional yield

Disclosed are T7 RNA polymerase variants with enhanced transcriptional activity. T7 RNA polymerase variants are known which have the ability to incorporate modified ribonucleotides into growing RNA molecules. However, these variants have relatively low levels of transcriptional activity. Presented herein are mutations that increase the transcriptional activity of the variants... The Board Of Regents Of The University Of Texas System

07/20/17 / #20170202964

Nitrobenzaldehyde proton release for manipulation of cellular acidosis

Certain embodiments are directed to photo-activated compounds for the manipulation of pH in a cell. In certain aspects the photo-activated compound is 2-nitrobenzaldehyde (NBA). Photo-activated compounds can be used as a targeted therapy for a variety of disease states and conditions, such as cancer.... The Board Of Regents Of The University Of Texas System

07/20/17 / #20170204078

Apigenin analogs, compositions, and methods related thereto

Certain embodiments are directed to apigenin analogues or derivatives. In certain aspects, the derivatives are developed as cystathionine-beta-synthase (CBS) inhibitors. In certain aspects, the derivatives are used as anticancer or anti-inflammatory agents. Certain embodiments are directed methods of treating or compositions used to treat fibrosis and cancers. In certain aspects... The Board Of Regents Of The University Of Texas System

Patent Packs
07/20/17 / #20170206557

Real-time, stream data information integration and analytics system

A real-time, stream data information integration and analytics system can include an information engine that performs real-time entity extraction to create key-value pairs of attributes for a personal profile and integrates similar personal profiles generated from same or different data sources into a single person-of-interest profile. The real-time, stream data... The Board Of Regents Of The University Of Texas System

07/13/17 / #20170197987

[1-3]-thiazine-fulleropyrrolo derivatives of c60 and c70 as hiv-inhibitor agents

Certain embodiments are directed to fullerene derivatives tetrahydro-1H—C60-fulleropyrrolo[1,2-c][1,3]thiazine salts (Formula I) or tetrahydro-1H—C70-fulleropyrrolo[1,2-c][1,3]thiazine salts (Formula II). Certain further embodiments are directed to α, β, γ, and/or δ isomer of tetrahydro-1H—C70-fulleropyrrolo[1,2-c][1,3]thiazine salt.... The Board Of Regents Of The University Of Texas System

07/06/17 / #20170189516

Compositions and methods for enterohemorrhagic escherichia coli (ehec) vaccination

Certain embodiments are directed to compositions comprising EHEC-specific antigens. In certain aspects EHEC O157:H7-specific antigen(s) are used as components of immunogenic compositions and vaccines.... The Board Of Regents Of The University Of Texas System

07/06/17 / #20170189558

Ultrasmall luminescent nanosensors compositions and applications

The present disclosure relates to the production and use of ultrasmall luminescent nanoparticles coupled to dyes and the obtained nanoparticles exhibit functionalities that can be highly sensitive to the local chemical environment changes. These nanoparticles may act as ultrasmall nanosensors to ratiometrically report pH or glutathione in the local environment.... The Board Of Regents Of The University Of Texas System

07/06/17 / #20170191032

Identification and isolation of neural stem cells and neurosphere initiating cells

The disclosure reports on the identification and isolation of adult mouse lateral ventricle subventricular zone (SVZ) neurosphere initiating cells (NICs) by flow cytometry on the basis of GlastmidEGFRhighPlexinB2highCD24−/lowO4/PSA-NCAM−/lowTer-119/CD45− markers (GEPCOT cells). These cells are highly mitotic and short-lived in vivo based on fate-mapping with Ascl1CreERT2 and Dlx1CreERT2. In contrast, pre-GEPCOT... The Board Of Regents Of The University Of Texas System

06/29/17 / #20170182030

Compounds and anti-tumor nqo1 substrates

Compositions comprising Formula (I) can be selectively lethal toward a variety of different cancer cell types. The compositions are useful for the management, treatment, control, or adjunct treatment of diseases, where the selective lethality is beneficial in chemotherapeutic therapy.... The Board Of Regents Of The University Of Texas System

06/29/17 / #20170182047
06/22/17 / #20170172987

Isoxazole treatments for frontotemporal dementia

The subject matter described here relates to the use of compounds and methods for the increase of progranulin expression. The methods may take place in vitro, ex vivo such as in isolates from adult mammalian tissue, or in vivo. Compounds and methods described herein may find use in the treatment... The Board Of Regents Of The University Of Texas System

06/22/17 / #20170173559

A porous metal-organic framework with pyrimidine groups for methane storage exhibiting high working capacity

Disclosed herein are metal-organic frameworks (MOF) and uses thereof, including those comprising a repeat unit of the formula [Cu2L(H2O)2]-5DMF-3H2O, wherein L is a ligand of the formula: These are useful for many applications, including in the purification of hydrogen gas from production byproducts CH4 and CO2, sensing, heterogeneous catalysis, drug... The Board Of Regents Of The University Of Texas System

06/22/17 / #20170176440

Methods and compositions for evaluating breast cancer patients

Embodiments are directed to methods of evaluating the prognosis of a breast cancer patient by assessing the level of phosphorylation tyrosine 36 of estrogen receptor beta (ERB). Certain embodiments are directed to methods for evaluating the prognosis of a cancer patient comprising contacting a breast cancer sample from a patient... The Board Of Regents Of The University Of Texas System

06/15/17 / #20170165320

Targeting of pelp1 in cancer therapy

The disclosure describes PELP1 binding peptides and peptoids and their use the interaction of PELP1 with molecules that lead to oncogenic signaling in cancers.... The Board Of Regents Of The University Of Texas System

06/15/17 / #20170166624

Tgfß type ii-type iii receptor fusions

Certain embodiments are directed to TGF-β inhibitors EUc and REUc. EUc is generated by removing the non-binding N-terminal subdomain from the TGF-β type III receptor, and REUc is generated by fusing together the binding domains of the TGF-β type II (RII or R) and type III receptor (RIII or EU)... The Board Of Regents Of The University Of Texas System

06/15/17 / #20170169276

Systems and methods for automated screening and prognosis of cancer from whole-slide biopsy images

Systems and methods for detection, grading, scoring and tele-screening of cancerous lesions are described. A complete scheme for automated quantitative analysis and assessment of human and animal tissue images of several types of cancers is presented. Various aspects of the invention are directed to the detection, grading, prediction and staging... The Board Of Regents Of The University Of Texas System

05/25/17 / #20170143852

Library of ph responsive polymers and nanoprobes thereof

The present disclosure relates to polymers which contain a hydrophobic and hydrophilic segment which is sensitive to pH. In some aspects, the polymers form a micelle which is sensitive to pH and results in a change in fluorescence based upon the particular pH. In some aspects, the disclosure also provides... The Board Of Regents Of The University Of Texas System

05/25/17 / #20170146542

Diagnostic test for early stage cancer

Disclosed are methods of identifying tumor-derived exosomes as an early cancer diagnostic, as well as for staging, assessing progression and assessing therapy of cancer.... The Board Of Regents Of The University Of Texas System

Patent Packs
05/11/17 / #20170131298

Apparatuses, methods and compositions for compound detection using interfacial nano-biosensing in microfluidic droplets

A simple interfacial nano-biosensing strategy for high-sensitivity detection of low-solubility compounds like 17β-estradiol is disclosed. Apparatuses, methods and compositions for detection incorporate a combination of droplet microfluidics with aptamer-functionalized GO nanosensors.... The Board Of Regents Of The University Of Texas System

05/04/17 / #20170119850

Method for treating chemotherapy-induced male infertility

A method of ameliorating, inhibiting, preventing, or reducing male infertility in a subject undergoing or in need of chemotherapy by administering to the subject a granulocyte colony-stimulating factor in a protective amount, prior to, during or after administration of one or more chemotherapeutic agents to the subject.... The Board Of Regents Of The University Of Texas System

05/04/17 / #20170121279

Lipocationic dendrimers and uses thereof

Modular dendrimers with cationic groups and lipophilic groups are provided herein. In some aspects, the dendrimers provided herein may be formulated in compositions which contain a nucleic acid and one or more helper excipients. In some aspects, these compositions may also be used to treat diseases or disorders with a... The Board Of Regents Of The University Of Texas System

05/04/17 / #20170122952

Diagnosis of benign and cancerous growths by measuring circulating tumor cells and serum annexina 2

Provided herein is a method for diagnosing/prognosing a metastatic cancer in a subject by measuring and detecting one or more of CS-ANXA2, DCAMKL, Lgr5 or CS-ANAX2 and DCAMKL or CS-ANXA2 and Lgr5 positive circulating tumor stem cells in the subject's blood or plasma. Also provided is a method for distinguishing... The Board Of Regents Of The University Of Texas System

04/27/17 / #20170112384

Optical laser catheter for intracorporeal diagnostic and treatment based photoacoustic spectroscopy

Certain embodiments are directed to an interventional device and methods of use of an interventional device comprising all-optical photoacoustic imaging and optionally further comprising at least one medical treatment device.... The Board Of Regents Of The University Of Texas System

04/27/17 / #20170112865

Treatment for melanoma

The present invention relates to combination therapies for melanoma, and in particular, metastatic melanoma. Drugs for use in such combination in include MEK inhibitors, BRAF inhibitors and cardiac glycosides.... The Board Of Regents Of The University Of Texas System

04/27/17 / #20170114062

Benzamide or benzamine compounds useful as anticancer agents for the treatment of human cancers

The described invention provides small molecule anti-cancer compounds for treating tumors that respond to cholesterol biosynthesis inhibition. The compounds selectively inhibit the cholesterol biosynthetic pathway in tumor-derived cancer cells, but do not affect normally dividing cells.... The Board Of Regents Of The University Of Texas System

04/20/17 / #20170105974

Use of mtor inhibitors for prevention of intestinal polyp growth and cancer

Disclosed are methods and compositions for the treatment or prevention of intestinal polyps or prevention of cancer in a patient who has been identified as being at risk for developing intestinal polyps or intestinal cancer. The disclosed methods and compositions include rapamycin, a rapamycin analog, or another such inhibitor of... The Board Of Regents Of The University Of Texas System

04/20/17 / #20170106103

New gadolinium-based contrast agents for sensitive detection of zn2+ with mri

In some aspects, the present disclosure provides novel ligands, which may be used to make novel MRI contrast agents for the detection of zinc. In further aspects, by the present disclosure also provides methods of using as imaging agents and compositions thereof.... The Board Of Regents Of The University Of Texas System

04/13/17 / #20170100482

Lipocationic polymers and uses thereof

Polymers produced by ring opening polymerization which comprises an amino group that can be used in compositions to deliver a nucleic acid such as a miRNA or a siRNA. In some embodiments, compositions which comprise the polymers described herein and a nucleic acid are also provided herein. In some embodiments,... The Board Of Regents Of The University Of Texas System

04/06/17 / #20170096476

Methods and compositions related to amyloid-beta-42 oligomers

Embodiments are directed to compositions comprising a conformation-dependent antibody that specifically binds oligomeric Aβ-42, and the methods of using the same.... The Board Of Regents Of The University Of Texas System

03/30/17 / #20170088875

Devices and methods using modified paper electrodes for the detection of hemoglobin a1c and glucose

Certain embodiments are directed to sensors that enable the use of optimized biocompatible materials such as pre-anodized paper printed electrode transducer to detect binding of a target agent, wherein the surface is modified or functionalized through zero length cross-linker so that it interacts with or specifically binds a target such... The Board Of Regents Of The University Of Texas System

03/30/17 / #20170089884

Animal model for evaluating filoviruses

The present invention includes methods of making, and compositions comprising, a uniformly lethal filovirus for outbred small mammals by mutation of the viral genome through serial passages in a small mammal, the method comprising the steps of: obtaining a filovirus strain from a human subject; passing the filovirus strain one... The Board Of Regents Of The University Of Texas System

03/30/17 / #20170093398

Configurable exclusive-or / exclusive-nor gate using magneto-electric tunnel junctions

A configurable ME MTJ XOR/XNOR gate includes an insulator separating a top and bottom FM layer, a top ME layer with a first boundary magnetism at an interface of the top ME layer and the top FM layer, a bottom ME layer with a second boundary magnetism at an interface... The Board Of Regents Of The University Of Texas System

03/23/17 / #20170081786

Method of preparing doped and/or composite carbon fibers

A method of producing doped carbon fibers, doped systems to prepare graphene-fiber hybrid structures, or doped carbon nanostructures, includes forming doped polymer precursors and decomposing at least a portion of the polymeric precursors to form carbon fibers. The decomposition may be accomplished by treating the doped polymer precursors with acid... The Board Of Regents Of The University Of Texas System

03/23/17 / #20170082615

Nanomaterial-based photothermal immunosensing for quantitative detection of disease biomarkers

Certain embodiments of the invention are directed to a photothermal immunoassay employing a thermometer or colorimetric detection method for sensitive quantitative readout based on the photothermal effect provided by a detection reagent.... The Board Of Regents Of The University Of Texas System

03/23/17 / #20170085367

Method and hybrid encryption

Described herein is a combination of mixed-signal hardware and software that is capable or realizing hybrid chaotic oscillators that can be tuned digitally. This includes the type/class of chaotic oscillator, initial conditions, nonlinear elements, thresholds, nonlinear event surfaces, delays, etc. At the same time, tunable methods of how to use... The Board Of Regents Of The University Of Texas System

03/16/17 / #20170071786

Contact lens handling device

Certain embodiments are directed to a contact lens application/removal device comprising a plurality of removably interconnection components. The components include a lens handling tip, a lubrication fluid container, two detachable storage chambers, and, optionally, a detachable ultraviolet disinfection system. The device can be used for contact lens removal, lubrication, storage,... The Board Of Regents Of The University Of Texas System

03/16/17 / #20170071940

Methionine aminopeptidase inhibitors for treating infectious diseases

The present invention relates to methods for treating an infectious disease in a subject in need thereof via administration of a therapeutically effective amount of compounds described herein. The methods may utilize particular compounds, for example, a quinoline, a hydrazone, a quinone, or a pyrimidine derivative thereof or a pharmaceutical... The Board Of Regents Of The University Of Texas System

03/16/17 / #20170071948

Methionine aminopeptidase inhibitors for treating infectious diseases

The present invention relates to methods for treating an infectious disease in a subject in need thereof via administration of a therapeutically effective amount of compounds described herein. The methods may utilize particular compounds, for example, a quinoline, a hydrazone, a quinone, or a pyrimidine derivative thereof or a pharmaceutical... The Board Of Regents Of The University Of Texas System

03/16/17 / #20170076040

Single-cell analysis as a sensitive and specific early cancer detection

Certain embodiments are directed to methods of measuring single cell levels of biomarkers associated with prostate cancer.... The Board Of Regents Of The University Of Texas System








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