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The Board Of Trustees Of The Leland Stanford Junior University
The Board Of Trustees Of The Leland Stanford Junior University Office Of The General Counsel
The Board Of Trustees Of The Leland Stanford Junior University And The Washington University
The Board Of Trustees Of The Leland Stanford Junior University And Cellgate Inc
The Board Of Trustees Of The Leland Stanford Junior University_20100128
The Board Of Trustees Of The Leland Stanford Junior University_20131212
The Board Of Trustees Of The Leland Stanford Junior Universitystanford University
The Board Of Trustees Of The Leland Stanford Junior University_20100107

The Board Of Trustees Of The Leland Stanford Junior University patents


Recent patent applications related to The Board Of Trustees Of The Leland Stanford Junior University. The Board Of Trustees Of The Leland Stanford Junior University is listed as an Agent/Assignee. Note: The Board Of Trustees Of The Leland Stanford Junior University may have other listings under different names/spellings. We're not affiliated with The Board Of Trustees Of The Leland Stanford Junior University, we're just tracking patents.

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Imaging tumor glycolysis by non-invasive measurement of pyruvate kinase m2

The present disclosure provides a positron emission tomography (PET)-detectable 1-((2-fluoro-6-[18F]fluorophenyl)sulfonyl)-4-((4-methoxyphenyl)sulfonyl)piperazine ([18F]DASA-23) probe that can selectively bind to the pyruvate kinase variant M2 (PKM2) found in cancer cells, such as of human glioma. Given the importance of PKM2 in the regulation of tumor metabolism, there is an on-going need to non-invasively... The Board Of Trustees Of The Leland Stanford Junior University

Customized load-bearing and bioactive functionally-graded implant for treatment of osteonecrosis

An engineered medical device for treatment of osteonecrosis is provided where the size, porosity and ceramic content of the device can be personalized based on an individual patient's anatomical and physiological condition. The device distinguishes different segments mimicking anatomically-relevant cortical and cancellous segments, in which the cortical segments of the... The Board Of Trustees Of The Leland Stanford Junior University

Opsin polypeptides and methods of use thereof

The present disclosure provides opsins, including variant opsins with increased activity and/or increased trafficking to the plasma membrane. The opsins are useful in therapeutic and screening applications, which are also provided.... The Board Of Trustees Of The Leland Stanford Junior University

Method and system for imaging and analysis of a biological specimen

The present disclosure provides methods of preparing a biological specimen for imaging analysis, comprising fixing and clearing the biological specimen and subsequently analyzing the cleared biological specimen using microscopy. Also included are methods of quantifying cells, for example, active populations of cells in response to a stimulant. The present disclosure... The Board Of Trustees Of The Leland Stanford Junior University

Device components formed of geometric structures

Various embodiments are directed to an apparatus and methods of forming and/or using an apparatus comprising a plurality of device components. An example method includes geometrically optimizing a periodic or aperiodic device comprising a plurality of device components by optimizing a topology, for each device component, from a starting point... The Board Of Trustees Of The Leland Stanford Junior University

Dual-modality imaging probe for combined localization and apoptosis detection of stem cells

A ferumoxytol-based dual-modality imaging probe for long-term stem cell tracking through MRI and early diagnosis of cell apoptosis through simultaneous fluorescence imaging is provided. Specifically, a ferumoxytol-based dual-modality imaging probe is provided with enhanced T2* relaxivity for tracking stem cells through magnetic resonance imaging and detecting apoptotic stem cells through... The Board Of Trustees Of The Leland Stanford Junior University

Disrupting fc receptor engagement on macrophages enhances efficacy of anti-sirpalpha antibody therapy

Anti-SIRPα antibodies, including multi-specific anti-SIRPα antibodies, are provided, as are related compositions and methods. The antibodies of the disclosure bind to SIRPα and can block the interaction of CD47 on one cell with SIRPα on a phagocytic cell. The subject anti-SIRPα antibodies find use in various therapeutic methods. Embodiments of... The Board Of Trustees Of The Leland Stanford Junior University

Compositions and methods for expressing polypeptides on the surface of cells

Methods and compositions are provided for displaying a protein of interest (POI) on the surface of a eukaryotic cell by fusing the POI to a signal polypeptide, a stalk polypeptide, and a surface anchor polypeptide to generate a surface accessible fusion protein. Nucleic acids are provided that include nucleotide sequences... The Board Of Trustees Of The Leland Stanford Junior University

Multifunctional energy storage composites

Described here is a multifunctional energy storage (MES) composite comprising (a) a stack of energy storage materials and (b) one or more structural facesheets sandwiching the stack of energy storage materials, wherein the stack of battery materials is perforated by (c) one or more reinforcements, and wherein the reinforcements are... The Board Of Trustees Of The Leland Stanford Junior University

Combination therapy for treatment of coronary artery disease

An effective combined dose of an anti-CD47 agent and an anti-TNF agent is administered to the subject in a dose and for a period of time effective to stabilize, prevent or reduce atherosclerotic plaque in the individual.... The Board Of Trustees Of The Leland Stanford Junior University

Immolative cell-penetrating complexes for nucleic acid delivery

There are provided herein, inter alia, complexes, compositions and methods for the delivery of therapeutic, diagnostic and imaging agents, including nucleic acid, into a cell. The complexes, compositions and methods may facilitate complexation, protection, delivery and release of oligonucleotides and polyanionic cargos into target cells, tissues, and organs both in... The Board Of Trustees Of The Leland Stanford Junior University

Electro-thermochemical li cycling for nh3 synthesis from n2 and h2o

An electro-thermochemical cycling system for producing ammonia is provided that includes a reaction chamber having a metal compound input port, an anode suitable for oxidation in contact with the metal compound and configured for oxidation of hydroxide ions to water and oxygen, a cathode suitable for plating in contact with... The Board Of Trustees Of The Leland Stanford Junior University

Producing mesodermal cell types and methods of using the same

Methods are provided for the generation of mesodermal cell types and derivatives thereof. Also provided are methods for generating purified populations of mesodermal cell types and derivatives thereof. The instant disclosure also provides methods of screening for cellular responses of the generated mesodermal cell types and derivatives thereof. Also provide... The Board Of Trustees Of The Leland Stanford Junior University

Modified axl peptides and their use in inhibition of axl signaling in anti-metastatic therapy

Compositions and methods are provided for alleviating cancer in a mammal by administering a therapeutic dose of a pharmaceutical composition that inhibits activity of AXL, MER or Tyro3 protein activity, for example by competitive or non-competitive inhibition of the binding interaction between AXL, MER or Tyro3 and its ligand GAS6.... The Board Of Trustees Of The Leland Stanford Junior University

Highly-multiplexed fluorescent imaging

Provided herein is a method and system for analyzing a sample. In some embodiments the method makes use of a plurality of capture agents that are each linked to a different oligonucleotide and a corresponding plurality of labeled nucleic acid probes, wherein each of the labeled nucleic acid probes specifically... The Board Of Trustees Of The Leland Stanford Junior University

Non-invasive diagnosis of graft rejection in organ transplant patients

The invention provides methods, devices, compositions and kits for diagnosing or predicting transplant status or outcome in a subject who has received a transplant.... The Board Of Trustees Of The Leland Stanford Junior University

Semiconductor devices including electrically isolated patterns and fabricating the same

A method of forming a composite dielectric material can be provided by performing a first deposition cycle to form a first dielectric material and performing a second deposition cycle to form a second dielectric material on the first dielectric material, wherein the first and second dielectric materials comprise different dielectric... The Board Of Trustees Of The Leland Stanford Junior University

System, method and applications involving identification of biological circuits such as neurological characteristics

Various aspects are directed to systems and methods for assessing neural activity of a neural region having multiple subfields. In certain embodiments, a method includes evoking a cellular electrical response in at least one subfield due to neural activity in the neural region, capturing image data of the electrical response... The Board Of Trustees Of The Leland Stanford Junior University

Novel methods, compounds, and compositions for anesthesia

Methods of treatment useful in the inducement or maintenance of anesthesia in a subject are provided. The methods comprise administering to a subject in need of anesthesia a compound disclosed herein. Also provided are novel compounds having anesthetic effects, pharmaceutical compositions comprising the compounds, and packaged pharmaceuticals. Computer modeling of... The Board Of Trustees Of The Leland Stanford Junior University

Markers of acute myeloid leukemia stem cells

Markers of acute myeloid leukemia stem cells (AMLSC) are identified. The markers are differentially expressed in comparison with normal counterpart cells, and are useful as diagnostic and therapeutic targets.... The Board Of Trustees Of The Leland Stanford Junior University

Ultrahigh-performance radiative cooler

A radiative cooler is provided having a thermally insulated vacuum chamber housing that is configured to support a vacuum level of at least 10-5 Torr, an infared-transparent window that is sealably disposed on top of the thermally insulated vacuum chamber and is transparet in the range of 8-13 μm, a... The Board Of Trustees Of The Leland Stanford Junior University

Device and methods of detection of airborne agents

Provided are methods, devices and systems that utilize free-surface fluidics and SERS for analyte detection with high sensitivity and specificity. The molecules can be airborne agents, including but not limited to explosives, narcotics, hazardous chemicals, or other chemical species. The free-surface fluidic architecture is created using an open microchannel, and... The Board Of Trustees Of The Leland Stanford Junior University

Method for multiplexed sample analysis by photoionizing secondary sputtered neutrals

Disclosed herein is a method of generating a high resolution image of a cellular sample, the method including i) labeling a cellular sample with at least one mass tag, thereby producing a labeled sample in which a biological feature of interest is associated with the at least one mass tag,... The Board Of Trustees Of The Leland Stanford Junior University

Superkines and synthekines: repurposed cytokines with new and enhanced signaling activities

Disclosed herein are IL-4 cytokine compositions with enhanced biological activity having increased selectivity for IL-4 cytokine receptors, and methods for their use. These compositions encompass interleukin-4 (IL-4) muteins. The disclosed methods encompass administering an IL-4 to treat neoplastic diseases, autoimmune diseases, infectious diseases or for expanding a hematopoietic cell population.... The Board Of Trustees Of The Leland Stanford Junior University

Methods for modulating genome editing

Provided herein are methods and kits for modulating genome editing of target DNA. The invention includes using small molecules that enhance or repress homology-directed repair (HDR) and/or nonhomologous end joining (NHEJ) repair of double-strand breaks in a target DNA sequence. Also provided herein are methods for preventing or treating a... The Board Of Trustees Of The Leland Stanford Junior University

Nanogrid electrochemical sensor for detection of biochemical species by electrochemical impedance spectroscopy

Improved electrochemical impedance spectroscopy assays are provided by electrodepositing metallic nanoparticles onto the working electrode for electrochemical impedance spectroscopy. The metallic nanoparticles provide improved assay sensitivity. Electrodeposition of the metallic nanoparticles firmly affixes them to the working electrode, thereby making it easier to clean the working electrode from one assay... The Board Of Trustees Of The Leland Stanford Junior University

Vivo iron labeling of stem cells and tracking these labeled stem cells after their transplantation

Intravenous ferumoxytol is used to effectively label mesenchymal stem cells (MSCs) in vivo and is used for in vivo tracking of stem cell transplants with magnetic resonance (MR) imaging. The method eliminates risk of contamination and biologic alteration of MSCs associated with ex-vivo-labeling procedures.... The Board Of Trustees Of The Leland Stanford Junior University

Circular nucleic acid vectors, and methods for making and using the same

Circular nucleic acid vectors that provide for persistently high levels of protein expression are provided. The circular vectors of the subject invention are characterized by being devoid of expression-silencing bacterial sequences, where in many embodiments the subject vectors include a unidirectional site-specific recombination product hybrid sequence in addition to an... The Board Of Trustees Of The Leland Stanford Junior University

Macrophages eat cancer cells using their own calreticulin as a guide

Therapeutic and diagnostic methods are provided, which methods relate to the induction of expression of calreticulin on phagocytic cells. Specifically, the methods relate to macrophage-mediated programmed cell removal (PrCR), the methods comprising increasing PrCR by contacting a phagocytic cell with a toll-like receptor (TLR) agonist; or down-regulating PrCR by contacting... The Board Of Trustees Of The Leland Stanford Junior University

Compositions and methods for delivering lypophilic agents to dental pulp and for enhancing dentin production

Methods and compositions are provided for enhancing dentin production, and for delivering a lipophilic agent to pulp tissue of a tooth of an individual. In some cases, a subject method includes a step of administering to the pulp of a tooth of an individual, a Wnt stimulating composition that includes... The Board Of Trustees Of The Leland Stanford Junior University

Protease-activated contrast agents for in vivo imaging

Compounds useful as contrast agents in image-guided surgery are provided. The compounds comprise a latent cationic lysosomotropic fragment that is detectable upon cleavage by lysosomal proteases within treated tissues, particularly within tumors and other diseased tissues. Also provided are compositions comprising the compounds and methods for using the compounds, for... The Board Of Trustees Of The Leland Stanford Junior University

Compositions of active wnt protein

Compositions of purified biologically active Wnt proteins are provided. Wnt proteins are found to be hydrophobic and post-translationally modified by addition of a lipid moiety at a conserved cysteine residue. Methods for isolation of Wnt utilize detergents that maintain the solubility of the modified protein.... The Board Of Trustees Of The Leland Stanford Junior University

Molecular analysis using a magnetic sifter and nanowell system

... The Board Of Trustees Of The Leland Stanford Junior University

Torque devices

Torque devices for navigating a guidewire through a body lumen are disclosed. The devices have a variable speed transmission design, including at least a first transmission region along a first position of the device, and a second transmission region along a second position of the device. The first and second... The Board Of Trustees Of The Leland Stanford Junior University

Direct conversion of cells to cells of other lineages

Methods, compositions and kits for producing functional neurons, astroctyes, oligodendrocytes and progenitor cells thereof are provided. These methods, compositions and kits find use in producing neurons, astrocytes, oligodendrocytes, and progenitor cells thereof for transplantation, for experimental evaluation, as a source of lineage- and cell-specific products, and the like, for example... The Board Of Trustees Of The Leland Stanford Junior University

12/28/17 / #20170369945

Methods of diagnosing autism spectrum disorders

Methods of screening subjects for genetic markers associated with autism spectrum disorders are disclosed. In particular, the invention relates to methods of diagnosing autism spectrum disorders by detecting the presence of deleterious mutations or aberrant expression of genes associated with autism spectrum disorders. The present invention relates to genetic markers... The Board Of Trustees Of The Leland Stanford Junior University

12/21/17 / #20170360813

Compositions and methods for treating medulloblastoma

Provided are methods and compositions for treating an individual who has a medulloblastoma. Methods for treating an individual who has a medulloblastoma tumor can include a step of administering to the individual, at a dose sufficient to reduce the size and/or growth rate of the medulloblastoma tumor, a composition that... The Board Of Trustees Of The Leland Stanford Junior University

12/21/17 / #20170360838

Factors and cells that provide for induction of bone, bone marrow, and cartilage

Methods, compositions and kits for producing functional chondrocytes, skeletal cells, bone marrow stromal cells, and progenitor cells thereof are provided. These methods, compositions and kits find use in producing chondrocytes, osteoblasts, stromal cells, and progenitor cells thereof in vivo, or in vitro for transplantation, for experimental evaluation, as a source... The Board Of Trustees Of The Leland Stanford Junior University

12/21/17 / #20170360962

Novel recombinant adeno-associated virus capsids resistant to pre-existing human neutralizing antibodies

The present invention relates to variant AAV capsid polypeptides, wherein the variant capsid polypeptides exhibit an enhanced neutralization profile, increased transduction and/or tropism in human liver tissue or hepatocyte cells (i.e., human hepatocyte cells), or both, as compared non-variant parent capsid polypeptides.... The Board Of Trustees Of The Leland Stanford Junior University

12/21/17 / #20170360965

Immuno-therapy for cancer treatment using iron oxide nanoparticles

An immuno-therapy for treatment of a tumor is provided. An effective dose of a composition containing a low dose of superparamagnetic iron oxide nanoparticle is administered to a tumor. Once the composition has been administered, it is recommended to avoid any means that would cause direct cytotoxic effects to the... The Board Of Trustees Of The Leland Stanford Junior University

12/21/17 / #20170362332

Cd47 targeted therapies for the treatment of infectious disease

Methods are provided for treating a subject with for an intracellular pathogen infection, by administering an agent that reduces the binding of CD47 on a infected cell to SIRPα on a host phagocytic cell, in an effective dose for increasing the phagocytosis of infected cells.... The Board Of Trustees Of The Leland Stanford Junior University

12/21/17 / #20170362642

Detection of target nucleic acids in a cellular sample

Methods of assaying cells of a cellular sample for the presence of a target nucleic acid are provided. Aspects of the methods include evaluating a cellular sample that has been contacted with a nuclease inhibitor for the presence of a target nucleic acid. Also provided are devices and kits that... The Board Of Trustees Of The Leland Stanford Junior University

12/21/17 / #20170367171

Apparatus for mm-wave radiation generation utilizing whispering gallery mode resonators

An apparatus for generating high frequency electromagnetic radiation includes a whispering gallery mode resonator, coupled to an output waveguide through a coupling aperture. The resonator has a guiding surface, and supports a whispering gallery electromagnetic eigenmode. An electron source is configured to generate a velocity vector-modulated electron beam, where each... The Board Of Trustees Of The Leland Stanford Junior University

12/14/17 / #20170354812

Drainage devices and methods for use

Devices and methods for draining excess lymph fluid are disclosed. The device can be fixed to the blood vessel adjacent to the thoracic duct. The device can have a port for withdrawing lymph fluid exiting the thoracic duct. The device can have a cannula and/or subcutaneous port to draw the... The Board Of Trustees Of The Leland Stanford Junior University

12/14/17 / #20170354816

Devices for delivery of electrical current to the body and related methods for therapy

A device for delivery of electrical current to an area of the skin includes a first pad shaped in the form of a base having four finger-shaped protrusions; a second pad shaped in the form of a palm having a single thumb-shaped protrusion, where the first pad and the second... The Board Of Trustees Of The Leland Stanford Junior University

12/14/17 / #20170354832

Trajectory optimization in radiotherapy using sectioning

A radiation therapy treatment method includes providing a patient model, dosimetric constraints, delivery motion constraints, and delivery coordinate space of a radiation delivery device, where the delivery coordinate space is represented as a mesh with vertices connected by edges, where the vertices correspond to directions of a beam eye view... The Board Of Trustees Of The Leland Stanford Junior University

12/14/17 / #20170355735

Conjugated knottin mini-proteins containing non-natural amino acids

Disclosed are knottin peptides containing non-natural amino acids so that they can be formed by chemical conjugation into two or more knottin monomers. The knottin monomers comprise a non-natural amino acid such as an aminooxy residue within the polypeptide sequence. The exemplified dimers were produced by oxime formation between two... The Board Of Trustees Of The Leland Stanford Junior University

12/14/17 / #20170358079

Systems, methods and devices for analyzing quantitative information obtained from radiological images

An example method for analyzing quantitative information obtained from radiological images includes identifying a ROI or a VOI in a radiological image, segmenting the ROI or the VOI from the radiological image and extracting quantitative features that describe the ROI or the VOI. The method also includes creating a radiological... The Board Of Trustees Of The Leland Stanford Junior University

12/14/17 / #20170358087

Systems and methods for performing three-dimensional semantic parsing of indoor spaces

Systems and methods for performing three-dimensional semantic parsing of indoor spaces in accordance with embodiments of the invention are disclosed. In one embodiment, a method includes receiving input data representing a three-dimensional space, determining disjointed spaces within the received data by generating a density histogram on each of a plurality... The Board Of Trustees Of The Leland Stanford Junior University

12/07/17 / #20170348433

Novel recombinant adeno-associated virus capsids resistant to pre-existing human neutralizing antibodies

The present invention relates to variant AAV capsid polypeptides, wherein the variant capsid polypeptides exhibit an enhanced neutralization profile, increased transduction and/or tropism in human liver tissue or hepatocyte cells (i.e., human hepatocyte cells), or both, as compared non-variant parent capsid polypeptides.... The Board Of Trustees Of The Leland Stanford Junior University

12/07/17 / #20170348525

Methods for enhancing and modulating reversible and irreversible electroporation lesions by manipulating pulse waveforms

A ratio of reversible electroporation and irreversible electroporation may be controlled by selecting a symmetric waveform or asymmetric waveform to either minimize or enhance irreversible effects on cells in the target tissue. Combined reversible and irreversible electroporation includes inserting one or more therapeutic electrodes into a target tissue, introducing an... The Board Of Trustees Of The Leland Stanford Junior University

12/07/17 / #20170348545

System for optical stimulation of target cells

Various systems and methods are implemented for controlling stimulus of a cell. One such method is implemented for optical stimulation of a cell expressing a NpHR ion pump. The method includes the step of providing a sequence of stimuli to the cell. Each stimulus increases the probability of depolarization events... The Board Of Trustees Of The Leland Stanford Junior University

12/07/17 / #20170349659

Wnt signaling agonist molecules

Wnt signaling agonist compositions and methods for their use are provided. Wnt signaling agonists of the invention comprise a frizzled binding moiety, which is fused or conjugated to an LRP5 or LRP6 binding moiety and to an R-spondin agonist.... The Board Of Trustees Of The Leland Stanford Junior University

12/07/17 / #20170350879

Long term hematopoietic stem cell specific reporter mouse and uses thereof

Hoxb5 identifies long-term hematopoietic stem cells. Expression of Hoxb5 distinguishes between LT-HSCs and non-LT-HSCs, and the marker identifies substantially all LT-HSC in the bone marrow. By utilizing fluorescent proteins under the endogenous expression control of Hoxb5, LT-HSC can be monitored and isolated, including without limitation detection and monitoring of HSC... The Board Of Trustees Of The Leland Stanford Junior University

12/07/17 / #20170353401

Dragonfly processor interconnect network

A multiprocessor computer system comprises a dragonfly processor interconnect network that comprises a plurality of processor nodes, a plurality of routers, each router directly coupled to a plurality of terminal nodes, the routers coupled to one another and arranged into a group, and a plurality of groups of routers, such... The Board Of Trustees Of The Leland Stanford Junior University

11/30/17 / #20170340608

Compounds and compositions that bind and stabilize transthyretin and their use for inhibiting transthyretin amyloidosis and protein-protein interactions

Disclosed herein are compounds and compositions thereof which find use in increasing stability of proteins particularly proteins that tend to misfold and form aggregates. Also provided herein are methods for using these compounds and compositions for increasing stability of proteins and thereby decreasing aggregate formation by these proteins. Also disclosed... The Board Of Trustees Of The Leland Stanford Junior University

11/30/17 / #20170343529

Single cell analysis using secondary ion mass spectrometry

A method of analyzing a population of cells is disclosed. In certain embodiments, the method includes i) obtaining an array of cells on a substrate, wherein the cells are labeled with one or more mass tags and are separated from one another, ii) measuring, using secondary ion mass spectrometry (SIMS),... The Board Of Trustees Of The Leland Stanford Junior University

11/30/17 / #20170346013

Polymer and electronic device and organic thin film transistor including the same

A polymer includes a first repeating unit and a second repeating unit forming a main chain, the first repeating unit including at least one first conjugated system, and the second repeating unit including at least one second conjugated system and a multiple hydrogen bonding moiety represented by Chemical Formula 1.... The Board Of Trustees Of The Leland Stanford Junior University

11/30/17 / #20170346119

Energy storage in closed loop systems using microbial conversion of carbon dioxide to hydrocarbon fuel

The invention integrates electromethanogenesis, which uses electric energy to produce fuel, with a method to capture and recycle the carbon dioxide generated when the fuel is used to release energy.... The Board Of Trustees Of The Leland Stanford Junior University

11/23/17 / #20170332992

Miniaturized phantoms for quantitative image analysis and quality control

Disclosed is a miniaturized phantom that can be placed against breast tissue during mammography. The phantom is provided with various radiological features that can be compared to the image of the breast tissue. The phantom is situated to be included in one or more mammography images. The phantom is at... The Board Of Trustees Of The Leland Stanford Junior University

11/23/17 / #20170333902

Systems and methods for automated single cell cytological classification in flow

Systems and methods in accordance with various embodiments of the invention are capable of rapid analysis and classification of cellular samples based on cytomorphological properties. In several embodiments, cells suspended in a fluid medium are passed through a microfluidic channel, where they are focused to a single stream line and... The Board Of Trustees Of The Leland Stanford Junior University

11/23/17 / #20170333903

Systems and methods for automated single cell cytological classification in flow

Systems and methods in accordance with various embodiments of the invention are capable of rapid analysis and classification of cellular samples based on cytomorphological properties. In several embodiments, cells suspended in a fluid medium are passed through a microfluidic channel, where they are focused to a single stream line and... The Board Of Trustees Of The Leland Stanford Junior University

11/23/17 / #20170334973

Non-human primate-derived pan-ebola and pan-filovirus monoclonal antibodies directed against envelope glycoproteins

The disclosure provides non-human primate-derived binding molecules, e.g., antibodies or antigen-binding fragments thereof, that can bind to orthologous epitopes found on two or more filovirus species or strains.... The Board Of Trustees Of The Leland Stanford Junior University

11/23/17 / #20170335287

Methods and compositions to maintain stem cell quiescence

Compositions and methods are provided for induction and maintenance of quiescence of stem cells.... The Board Of Trustees Of The Leland Stanford Junior University

11/16/17 / #20170325697

Probe for detecting atherosclerosis

A probe device for detecting atherosclerotic plaque may include: an elongate shaft having a proximal end for coupling with a catheter and a distal end; an opening in a side of the shaft; a scintillating window disposed over the opening to form a water tight seal and thus form an... The Board Of Trustees Of The Leland Stanford Junior University

Patent Packs
11/16/17 / #20170327841

Dopamine receptor type 2 specific promoter and methods of use thereof

A nucleic acid containing a dopamine receptor type 2-specific promoter (D2SP) is provided. In certain embodiments, the nucleic acid includes a dopamine receptor type 2-specific promoter (D2SP), wherein the D2SP does not include exon 1 of a D2 receptor gene, wherein the D2SP comprises a Kozak sequence, and wherein the... The Board Of Trustees Of The Leland Stanford Junior University

11/09/17 / #20170319123

Systems and methods for using mobile and wearable video capture and feedback plat-forms for therapy of mental disorders

Behavioral and mental health therapy systems in accordance with several embodiments of the invention include a wearable camera and/or a variety of sensors (accelerometer, microphone, among various other) connected to a computing system including a display, audio output, holographic output, and/or vibrotactile output to automatically recognize social cues from images... The Board Of Trustees Of The Leland Stanford Junior University

11/09/17 / #20170320041

Affinity reagents for protein purification

Disclosed herein are methods and compositions for purifying proteins from crude solutions.... The Board Of Trustees Of The Leland Stanford Junior University

11/09/17 / #20170320828

Mitochondrial aldehyde dehydrogenase-2 modulators and methods of use thereof

The present disclosure provides compounds of formula (I) that function as modulators of mitochondrial aldehyde dehydrogenase-2 (ALDH2) activity, and methods of preparing these compounds.... The Board Of Trustees Of The Leland Stanford Junior University

11/09/17 / #20170320945

Methods for manipulating phagocytosis mediated by cd47

Methods are provided to manipulate phagocytosis of cells, including hematopoietic cells, e.g. circulating hematopoietic cells, bone marrow cells, acute leukemia cells, etc.; and solid tumor cells. In some embodiments of the invention the circulating cells are hematopoietic stem cells, or hematopoietic progenitor cells, particularly in a transplantation context, where protection... The Board Of Trustees Of The Leland Stanford Junior University

11/09/17 / #20170321257

Bacterial pathogen identification by high resolution melting analysis

Methods and oligonucleotide reagents for identification of bacteria by high resolution melting (HRM) analysis are described. In particular, the invention relates to HRM analysis of hypervariable bacterial genomic DNA of the internal transcribed spacer (ITS) region for fingerprinting eubacterial pathogens.... The Board Of Trustees Of The Leland Stanford Junior University

11/09/17 / #20170321821

Elastomeric focusing valves

A fluid valve is provided that includes a first planar substrate having a smooth surface or a surface with features, an elastomer disposed on the first substrate, a second planar substrate disposed on another side of the elastomer, where the second substrate has a smooth surface or features, where the... The Board Of Trustees Of The Leland Stanford Junior University

11/09/17 / #20170322626

Wolverine: a wearable haptic interface for grasping in virtual reality

A mobile, wearable haptic device (the Wolverine) designed for simulating the grasping of objects in a virtual reality interface is disclosed. The Wolverine renders a force directly between the thumb and at least one finger to simulate opposition type grasps of the objects. Mechanical design, control strategy, and performance analysis... The Board Of Trustees Of The Leland Stanford Junior University

11/09/17 / #20170325326

Apparatus for mm-wave radiation generation utilizing whispering gallery mode resonators

An apparatus for generating high frequency electromagnetic radiation includes a whispering gallery mode resonator, coupled to an output waveguide through a coupling aperture. The resonator has a guiding surface, and supports a whispering gallery electromagnetic eigenmode. An electron source is configured to generate a velocity vector-modulated electron beam, where each... The Board Of Trustees Of The Leland Stanford Junior University

11/02/17 / #20170312282

Tyrosine kinase inhibitor formulations for the treatment of mast cell-mediated inflammatory diseases and methods of use thereof

Methods of treating mast cell-mediated inflammatory diseases are provided by local administration a therapeutically effective amount of a tyrosine kinase inhibitor to a patient in need thereof.... The Board Of Trustees Of The Leland Stanford Junior University

11/02/17 / #20170312316

Cartilage cells with a high regenerative potential and low immune response for use in cellular therapy

Cell-based therapies for cartilage repair and regeneration selectively using chondrocytes carrying a CD24 surface marker are disclosed. In particular, chondrocytes carrying the CD24 surface marker have a high regenerative potential and low responsiveness to inflammatory cues. Since cartilage injuries as well as chronic cartilage degenerative conditions are often accompanied by... The Board Of Trustees Of The Leland Stanford Junior University

11/02/17 / #20170312319

Pericytes are intermediate progenitors for epicardial derived coronary artery smooth muscle

Methods and compositions are provided for regenerating smooth muscle tissue by the provision of a purified population of epicardial-derived pericytes, where the smooth muscle tissue may comprise, without limitation, coronary artery tissue; kidney tissue, etc. Compositions and kits for practicing the methods and/or for use with the systems of the... The Board Of Trustees Of The Leland Stanford Junior University

11/02/17 / #20170312332

Inhibitors of mitochondrial fission and methods of use thereof

The present disclosure provides peptides and constructs that inhibit mitochondrial fission, and compositions comprising the peptides or constructs. The present disclosure provides methods of reducing abnormal mitochondrial fission in a cell. Also provided are methods for designing and validating mitochondrial fission inhibitor constructs and peptides, including but not limited to,... The Board Of Trustees Of The Leland Stanford Junior University

11/02/17 / #20170312920

Position/force control of a flexible manipulator under model-less control

A method includes receiving position information and force information, providing control commands to a steering mechanism of a continuum manipulator based on the position information and the force information, updating a control matrix based on the position information and the provided control commands, and providing updated control commands to the... The Board Of Trustees Of The Leland Stanford Junior University

11/02/17 / #20170314878

Structures for radiative cooling

Various aspects as described herein are directed to a radiative cooling device and method for cooling an object. As consistent with one or more embodiments, a radiative cooling device includes a solar spectrum reflecting structure configured and arranged to suppress light modes, and a thermally-emissive structure configured and arranged to... The Board Of Trustees Of The Leland Stanford Junior University

Patent Packs
11/02/17 / #20170316569

Robust anytime tracking combining 3d shape, color, and motion with annealed dynamic histograms

Velocity controllers in accordance with embodiments of the invention enable velocity estimation for tracked objects. One embodiment includes a tracker controller, including: a processor; and a memory containing: a velocity tracker application; a state space describing relationships between measured locations, calculated locations, and changes in locations, where the calculated locations... The Board Of Trustees Of The Leland Stanford Junior University

10/26/17 / #20170304269

Method for treating neurodegenerative diseases

The present invention is directed to a method for treating a neurodegenerative disease such as amyotrophic lateral sclerosis (ALS), Alzheimer disease, Parkinson's disease, Huntington's disease, frontotemporal degeneration, dementia with Lewy bodies, a motor neuron disease, or a demyelinating disease. The method comprises administering to a subject in need thereof a... The Board Of Trustees Of The Leland Stanford Junior University

10/26/17 / #20170304342

Knottin-drug conjugates and methods of using the same

Provided are knottin-drug conjugates. The conjugates include a knottin peptide that includes an engineered loop that binds to a target on a cancer cell surface, and a drug (e.g., a nucleoside drug) conjugated to the knottin peptide through a linker. Also provided are pharmaceutical compositions and kits that include the... The Board Of Trustees Of The Leland Stanford Junior University

10/26/17 / #20170304902

Synthesis of water-soluble thiolate-protected gold nanoparticles of uniform size and conjugates thereof

Methods of synthesizing water-soluble thiolate-protected gold nanoparticles of uniform size and conjugates thereof are disclosed. In particular, the invention relates to a method of synthesizing homogeneous, water-soluble gold nanoparticles by using a modified Brust procedure and methods of conjugating them. Gold nanoparticles, produced by the methods of the invention, are... The Board Of Trustees Of The Leland Stanford Junior University

10/26/17 / #20170305985

Hepatocyte growth factor fragments that function as potent met receptor agonists and antagonists

The NK1 fragment of hepatocyte growth factor (HGF) binds to and activates the Met receptor, a transmembrane receptor tyrosine kinase that plays a critical role in embryonic development and organ formation. The instant application discloses NK1 variant polypeptides which act as agonists or antagonists of HGF. Further disclosed are covalently... The Board Of Trustees Of The Leland Stanford Junior University

10/26/17 / #20170306029

Wnt signaling agonist molecules

Wnt signaling agonist compositions and methods for their use are provided. Wnt signaling agonists of the invention comprise a frizzled binding moiety, which is fused or conjugated to an LRP5 or LRP6 binding moiety.... The Board Of Trustees Of The Leland Stanford Junior University

10/26/17 / #20170306394

Devices and methods for controlling reversible chemical reactions at solid-liquid interfaces by rapid preconcentration and phase replacement

Devices and methods for controlling reversible chemical reactions at solid-liquid interfaces are disclosed. In particular, the invention relates to a method of increasing reaction rates by concentrating a target molecule in a liquid phase in the region of a reactant or ligand immobilized on a solid followed by removal of... The Board Of Trustees Of The Leland Stanford Junior University

10/26/17 / #20170306413

Methods for determining responsiveness to an anti-cd47 agent

Methods and kits are provided for determining whether an individual is responsive to an anti-CD47 agent by assaying biological samples for the level or ratio of isoforms of CD47 in the sample.... The Board Of Trustees Of The Leland Stanford Junior University

10/26/17 / #20170306425

Methods and reagents for detection, quantitation, and serotyping of dengue viruses

Methods and oligonucleotide reagents for diagnosing dengue virus infection are described. In particular, the invention relates to methods for detection, quantitation, and serotyping dengue virus, including serotypes 1-4. The dengue virus can be specifically detected by these methods even in samples containing other viruses, such as West Nile virus, Japanese... The Board Of Trustees Of The Leland Stanford Junior University

10/26/17 / #20170307549

Single x-ray grating x-ray differential phase contrast imaging system

Single X-ray grating differential phase contrast (DPC) X-ray imaging is provided by replacing the conventional X-ray source with a photo-emitter X-ray source array (PeXSA), and by replacing the conventional X-ray detector with a photonic-channeled X-ray detector array (PcXDA). These substitutions allow for the elimination of the G0 and G2 amplitude... The Board Of Trustees Of The Leland Stanford Junior University

10/26/17 / #20170307627

High resolution imaging of tissue proteins

The present invention provides labeling method for Array Tomography (AT) and immunohistochemistry (IHC) that enables automated analysis many tens-to-hundreds of proteins in a manner that minimizes tissue degradation, increases data fidelity, and substantially increases throughput and reduces cost. Also included are methods for automated acquisition of AT and IHC data.... The Board Of Trustees Of The Leland Stanford Junior University

10/26/17 / #20170307713

System and imaging four-dimensional flow of a fluid within a volume of an imaged object

A method for phase-contrast imaging a fluid within a volume of an imaged subject is provided. The method includes acquiring a plurality of slabs, each slab imaging the fluid flowing within a portion of the volume; and volume merging the plurality of slabs to form an image of the volume.... The Board Of Trustees Of The Leland Stanford Junior University

10/19/17 / #20170296060

Microscopy imaging device with advanced imaging properties

Systems, methods and devices are implemented for microscope imaging solutions. One embodiment of the present disclosure is directed toward an epifluorescence microscope. The microscope includes an image capture circuit including an array of optical sensor. An optical arrangement is configured to direct excitation light of less than about 1 mW... The Board Of Trustees Of The Leland Stanford Junior University

10/19/17 / #20170296806

Nanopillar electrode devices and methods of recording action potentials

This disclosure provide a nanopillar electrode device, comprising a substrate patterned with a plurality of metal pads. The device may further comprise a plurality of nanopillars electrode arrays, wherein each nanopillar electrode array is attached to the substrate above a metal pad and electrically connected to the pad. The device... The Board Of Trustees Of The Leland Stanford Junior University

10/19/17 / #20170298348

Genome editing of human neural stem cells using nucleases

The invention provides methods for generating a genetically modified human neural stem cell, genetically modified human neural stem cells, and pharmaceutical compositions comprising the genetically modified human neural stem cells. Also provided are associated kits. The invention also provides methods for preventing or treating a neurodegenerative disease or a neurological... The Board Of Trustees Of The Leland Stanford Junior University

10/19/17 / #20170298422

Simultaneous single-molecule epigenetic imaging of dna methylation and hydroxymethylation

Provided herein is a method for analyzing genomic DNA. In some embodiments, the method may comprise labeling a genomic sample by adding a capture tag to the ends of the DNA molecules in the sample and labeling molecules that comprise hydroxymethylcytosine with a first fluorophore, immobilizing the labeled DNA molecules... The Board Of Trustees Of The Leland Stanford Junior University

10/19/17 / #20170298455

Composition and imaging stem cells

An expression vector, comprising a first reporter nucleic acid sequence operably linked to a first expression control sequence comprising a promoter; and a second reporter nucleic acid sequence operably linked to a second expression control sequence that comprises a response element that is activated or inactivated as one or more... The Board Of Trustees Of The Leland Stanford Junior University

10/19/17 / #20170299525

Microwave impedance microscopy using a tuning fork

A microwave impedance microscope including a tuning fork having a high-aspect ratio etched metal tip electrode extending transversely to one tine of the fork and having a high aspect ratio to thereby reduce parasitic capacitance. The metal tip may be electrochemically etched from a wire, then bonded to the tine.... The Board Of Trustees Of The Leland Stanford Junior University

10/19/17 / #20170299679

Method for estimating t2

A method for providing an estimated 3D T2 map for magnetic resonance imaging using a Double-Echo Steady-State (DESS) sequence for a volume of an object in a magnetic resonance imaging (MRI) system is provided. A DESS scan of the volume is provided by the MRI system. Signals S1 and S2... The Board Of Trustees Of The Leland Stanford Junior University

10/19/17 / #20170299682

Field-mapping and artifact correction in multispectral imaging

A method for generating a magnetic resonance image of an object in a magnetic resonance imaging (MRI) system, wherein the object contains at least one metallic implant is provided. The MRI system provides multiple excitations of at least part of the object. The MRI system reads out image signals from... The Board Of Trustees Of The Leland Stanford Junior University

10/12/17 / #20170290890

Stimulation of ovarian follicle development and oocyte maturation

Methods are provided for stimulating ovarian follicles in a mammal through activation of the mTor signaling pathway.... The Board Of Trustees Of The Leland Stanford Junior University

10/12/17 / #20170291945

Targeting aneurysm disease by modulating phagocytosis pathways

In the methods of the invention, an agent that increases phagocytosis and/or efferocytosis of cellular components of coronary plaque is administered to the subject in a dose and for a period of time effective to stabilize, prevent or reduce aneurysm disease in the individual.... The Board Of Trustees Of The Leland Stanford Junior University

10/12/17 / #20170292915

Scalable bio-element analysis

A method is provided for detecting one or more analytes in a sample. The method relies, in part, on the ability of functionalized particles added to the sample to partially or completely inhibit the transmission of electromagnetic radiation into and out of the sample through a detection surface in a... The Board Of Trustees Of The Leland Stanford Junior University








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