The Brigham And Women s Hospital Inc patents list (updated weekly)

Placement manipulator and attachment for positioning a puncture instrument

An apparatus (51) includes a needle placement manipulator (1) and an attachment (52) for the manipulator. The manipulator includes a needle holder and a rotary mechanism. The rotary mechanism (3, 4) has a remote center of motion (RCM: 11) and is configured to position a needle holder (5) such that... The Brigham And Women s Hospital Inc

Medical support device

There is provided a medical support device for holding and positioning a needle. This device is particularly useful for positioning needles in a less invasive puncture treatment. This device comprises two rotational elements and at least one needle guide attached to a rotational element and. The needle guide guides the... The Brigham And Women s Hospital Inc

Vibro-based delivery system and immune suppression

Embodiments described are immunosuppressant therapeutics and compositions comprising a Vop protein derived from Vibro parahaemolyticus; and drug delivery vehicles derived from a V. parahaemolyticus expressing a mutant VopZ protein lacking amino acid residue 38-62.... The Brigham And Women s Hospital Inc

Multipotent stem cells and uses thereof

The invention provides a quiescent stem cell having the capacity to differentiate into ectoderm, mesoderm and endoderm, and which does not express cell surface markers including MHC class I, MHC class II, CD44, CD45, CD13, CD34, CD49c, CD73, CD105, CD90, CD66A, CD66E, CXCR4, CD133 or an SSEA. The invention further... The Brigham And Women s Hospital Inc

Multipotent stem cells and uses thereof

The invention provides a quiescent stem cell having the capacity to differentiate into ectoderm, mesoderm and endoderm, and which does not express cell surface markers including MHC class I, MHC class II, CD44, CD45, CD13, CD34, CD49c, CD73, CD105, CD90, CD66A, CD66E, CXCR4, CD133 or an SSEA. The invention further... The Brigham And Women s Hospital Inc

Tolerogenic nanoparticles for treating diabetes mellitus

Methods and compositions for increasing the number and/or activity of regulatory T cells (Tregs) in vivo and in vitro, to induce tolerance to diabetogenic autoantigens.... The Brigham And Women s Hospital Inc

Multipotent stem cells and uses thereof

The invention provides a quiescent stem cell having the capacity to differentiate into ectoderm, mesoderm and endoderm, and which does not express cell surface markers including MHC class I, MHC class II, CD44, CD45, CD13, CD34, CD49c, CD73, CD105, CD90, CD66A, CD66E, CXCR4, CD133 or an SSEA. The invention further... The Brigham And Women s Hospital Inc

Bi-specific antibodies against tim-3 and pd-1 for immunotherapy in chronic immune conditions

Described herein are novel compositions comprising bispecific and multispecific polypeptide agents, and methods using these agents for targeting cells, such as functionally exhausted or unresponsive immune cells, that co-express the inhibitory receptors PD-1 and TIM-3. These compositions and methods are useful for the treatment of chronic immune conditions, such as... The Brigham And Women s Hospital Inc

Compounds and methods for modulating pharmacokinetics

Methods and compositions are described for management of the pharmacokinetic properties of active agents, e.g., therapeutic moieties, by conjugating, fusing, or non-direct linkage of the active agent to one or more wild-type or modified heparin-binding peptides (HB). Compounds may be administered to tissues including skin. Contemplated uses include treatment of... The Brigham And Women s Hospital Inc

Continuous and rapid quantification of stroke volume from magnetohydrodynamic voltages in magnetic resonance imaging

Described here are systems and methods for providing a non-invasive and continuous quantitative measurement of left ventricular stroke volume (“SV”) and flow volume during a magnetic resonance imaging (“MRI”) scan. In general, the method estimates quantitative measurements of SV from magnetohydrodynamic (“MHD”] voltages generated by blood flowing through the subject's... The Brigham And Women s Hospital Inc

Treatment of cancer with anti-lap monoclonal antibodies

Described herein are compositions and methods relating to LAP-binding agents, including, for example, anti-LAP antibodies, and to their use in methods of treatment of cancer. LAP-binding agents affected both systemic and intra-tumor immunity and were shown effective to treat a broad spectrum of cancer types.... The Brigham And Women s Hospital Inc

Methods and compositions for the treatment or prevention of abnormal bone formation in a soft tissue

Provided herein are methods and compositions for the treatment and/or prevention of abnormal bone formation in a soft tissue. In certain embodiments, the methods and compositions treat and/or prevent a disease or disorder comprising abnormal bone formation in soft tissue. Exemplary diseases or disorders that can be treated with the... The Brigham And Women s Hospital Inc

Receptor-targeted nanoparticles for enhanced transcytosis mediated drug delivery

Receptor-targeted nanoparticles (R-NPs) are provided for selective transport into and through targeted tissues of therapeutic, prophylactic and diagnostic agents. R-NPs can include polymeric particle, lipid particles, inorganic particles, or a combination thereof with a targeting moiety selective for binding to a receptor on the cells where the agent is to... The Brigham And Women s Hospital Inc

Methods and compositions for the treatment or prevention of abnormal bone formation in a soft tissue

Provided herein are methods and compositions for the treatment and/or prevention of abnormal bone formation in a soft tissue. In certain embodiments, the methods and compositions treat and/or prevent a disease or disorder comprising abnormal bone formation in soft tissue. Exemplary diseases or disorders that can be treated with the... The Brigham And Women s Hospital Inc

Micrornas in neurodegenerative disorders

Provided herein are methods of treating a neurodegenerative disorder such as Amyotrophic Lateral Sclerosis (ALS) or Multiple Sclerosis (MS) that include administering to a subject at least one inhibitory nucleic acid that decreases the level or activity of microRNA has-miR-155.... The Brigham And Women s Hospital Inc

Treatment of cancer with anti-lap monoclonal antibodies

Described herein are compositions and methods relating to LAP-binding agents, including, for example, anti-LAP antibodies, and to their use in methods of treatment of cancer. LAP-binding agents affected both systemic and intra-tumor immunity and were shown effective to treat a broad spectrum of cancer types.... The Brigham And Women s Hospital Inc

Method of identifying and treating a person having a predisposition to or afflicted with a cardiometabolic disease

The invention relates to method for identifying and selecting a subject with increased risk of developing a cardiometabolic disease and optionally, providing a personalized medicine method, which may involve sequencing at least part of a genome of one or more cells in a blood sample of the subject and identifying... The Brigham And Women s Hospital Inc

Use of cadherin-11 antagonists to treat obesity-associated conditions and other metabolic disorders

Provided herein are methods and pharmaceutical compositions for the treatment of obesity-associated conditions using cadherin-11 antagonists.... The Brigham And Women s Hospital Inc

Disulfide polymers and methods of use

Provided herein are disulfide polymers, methods of their preparation, compositions, and methods of using the same. For example, provided herein are polymers having at least one repeating unit according to Formula (I):or Formula (II): and nanoparticles and compositions including the same. The polymers and compositions provided herein may be used,... The Brigham And Women s Hospital Inc

Mitochondrial phosphate carrier targets for treating soft-tissue calcification

Disclosed herein are compositions and methods for treating soft-tissue calcification by targeting SLC25A24 and/or SLC25A3.... The Brigham And Women s Hospital Inc

14-hydroxy-docosahexaenoic acid compounds

The invention describes novel 14-hydroxy docosahexaenoic acid (DHA) analogues, their preparation, isolation, identification, purification and uses thereof.... The Brigham And Women s Hospital Inc

Production of differentiated enteroendocrine cells and insulin producing cells

A population of enteroendocrine cells (EEC) is obtained from a mammalian post-natal cell population, such as a population including post-natal stem cells, by treating the population with a plurality of small molecules that upregulate ChgA and promote differentiation of the cells to form the enteroendocrine cells. The upregulation of ChgA... The Brigham And Women s Hospital Inc

T cell balance gene expression, compositions of matters and methods of use thereof

This invention relates generally to compositions and methods for identifying the regulatory network that modulates, controls or otherwise influences T cell balance, for example, Th17 cell differentiation, maintenance and/or function, as well compositions and methods for exploiting the regulatory network that modulates, controls or otherwise influences T cell balance in... The Brigham And Women s Hospital Inc

Natural igm antibodies and inhibitors thereof

The invention provides natural IgM antibody inhibitors that may be used to treat various inflammatory diseases or disorders.... The Brigham And Women s Hospital Inc

Diagnosing and monitoring cns malignancies using microrna

The use of specific microRNAs (miRNAs) present in CSF as biomarkers for particular brain malignancies and disease activity.... The Brigham And Women s Hospital Inc

Mass production and size control of nanoparticles through controlled microvortices

Methods for making particles, such as nanoparticles, devices useful in the methods, and particles made by the method are described herein. The methods involves the use of microfluidic device, such that upon mixing solutions of the materials to form the particles (or a solution of the material or materials to... The Brigham And Women s Hospital Inc

Melatonin in autoimmune disease

Methods for treating, or reducing risk of developing, seasonal worsening of multiple sclerosis (MS) in a subject who has MS, comprising administering a melatonin agonist to a subject.... The Brigham And Women s Hospital Inc

Targeting apolipoprotein e (apoe) in neurologic disease

Methods for treating neurologic diseases, e.g., amyotrophic lateral sclerosis (ALS) and multiple sclerosis, by modulating the APOE-TGFbeta pathway. The methods include administering one or more inhibitory nucleic acids targeting Trem2 and/or ApoE), sense nucleic acids encoding Egr1 and/or Mertk, and/or antibodies that bind to and inhibit Trem2 and/or ApoE.... The Brigham And Women s Hospital Inc

Polymorphism in the apo(a) gene predict responsiveness to acetylsalicylic acid treatment

This invention relates to nucleotide polymorphisms in the human Apo(a) gene and to the use of Apo(a) nucleotide polymorphisms in identifying whether a human subject will respond or not to treatment with acetylsalicylic acid.... The Brigham And Women s Hospital Inc

Melatonin in autoimmune disease

Methods for treating, or reducing risk of developing, seasonal worsening of multiple sclerosis (MS) in a subject who has MS, comprising administering a melatonin agonist to a subject.... The Brigham And Women s Hospital Inc

Anti-ceacam1 recombinant antibodies for cancer therapy

Provided herein are recombinant monoclonal antibodies and antigen-binding portions thereof useful in inhibiting CEACAM1 in tumor cells, and methods of their use in anti-tumor proliferation and invasiveness therapies, such as the treatment of cancer, particularly pancreatic cancer.... The Brigham And Women s Hospital Inc

Self assembled gels for controlled delivery of encapsulated agents to cartilage

A self-assembled gel composition with enhanced adhesion to cartilage tissue is provided. A cationic agent co-self assembles with a generally regarded as safe (GRAS), low molecular weight (<2,500 Da) gelator, forming homogeneous self-supporting gel that can encapsulate one or more therapeutic agents for controlled release. The composition adheres to connective... The Brigham And Women s Hospital Inc

Self-assembled gels for controlled delivery of biologics and labile agents

Gels are formed based on generally recognized as safe (GRAS) low molecular weight amphiphilic molecules in a self-assembly process with limited or no heating. A selective range of ratios between an organic solvent and water, or an aqueous solution, in the medium, allows for the GRAS low molecular weight amphiphiles... The Brigham And Women s Hospital Inc

Multipotent stem cells and uses thereof

The invention provides a quiescent stem cell having the capacity to differentiate into ectoderm, mesoderm and endoderm, and which does not express cell surface markers including MHC class I, MHC class II, CD44, CD45, CD13, CD34, CD49c, CD73, CD105 and CD90. The invention further provides a proliferative stem cell, which... The Brigham And Women s Hospital Inc

14-hydroxy-docosahexaenoic acid compounds

The invention describes novel 14-hydroxy docosahexaenoic acid (DHA) analogues, their preparation, isolation, identification, purification and uses thereof.... The Brigham And Women s Hospital Inc

11/02/17 / #20170311894

Ingestible power harvesting device, and related applications

Aspects disclosed in the detailed description include an ingestible power harvesting device and related applications. An ingestible power harvesting device includes a cathode electrode and an anode electrode that can catalyze a power generating reaction to generate a direct current (DC) power when surrounded by an acidic electrolyte. The cathode... The Brigham And Women s Hospital Inc

11/02/17 / #20170313983

Multipotent stem cells and uses thereof

The invention provides a quiescent stem cell having the capacity to differentiate into ectoderm, mesoderm and endoderm, and which does not express cell surface markers including MHC class I, MHC class II, CD44, CD45, CD13, CD34, CD49c, CD73, CD105, CD90, CD66A, CD66E, CXCR4, CD133 or an SSEA. The invention further... The Brigham And Women s Hospital Inc

11/02/17 / #20170313769

Interferon beta antibodies and uses thereof

The invention relates to antibodies, or antigen-binding fragments thereof, that specifically binds to interferon beta (IFNβ). Such antibodies, or antigen-binding fragments thereof, are useful for various therapeutic or diagnostic purposes.... The Brigham And Women s Hospital Inc

10/26/17 / #20170303953

Surgical instruments with selectively rotating handles

This disclosure relates to surgical instruments with selectively rotating handles. In certain aspects, the surgical device includes a conduit having a longitudinal axis and configured to extend into a body lumen, and a handle coupled to the conduit and configured to selectively rotate relative to the conduit. The handle is... The Brigham And Women s Hospital Inc

10/26/17 / #20170305883

Compositions and methods for inhibiting bmp

The present invention provides small molecule inhibitors of BMP signaling and compositions and methods for inhibiting BMP signaling. These compounds and compositions may be used to modulate cell growth, differentiation, proliferation, and apoptosis, and thus may be useful for treating diseases or conditions associated with BMP signaling, including inflammation, cardiovascular... The Brigham And Women s Hospital Inc

10/26/17 / #20170309022

Systems and methods for generating biomarkers based on multivariate classification of functional imaging and associated data

Systems and methods for generating biomarkers associated with neuropsychiatric disorders, neurodevelopmental disorders, neurobehavioral disorders, or other neurological disorders are described. In general, the biomarkers are generated based on correlations between functional imaging data and clinical acquired from a subject, as computed using a multivariate classifier. Functional imaging data may include... The Brigham And Women s Hospital Inc

10/19/17 / #20170298128

Methods and compositions for treating age-related disorders

The present invention relates to methods and compositions containing an antagonist of a negative regulator of GDF-11 (e.g., an antibody) for use in treating an age-related condition. In particular the methods and compositions can be used to treat an age related cardiovascular condition such as diastolic heart failure.... The Brigham And Women s Hospital Inc

10/12/17 / #20170292126

Neuroprotective molecules and methods of treating neurological disorders and inducing stress granules

Provided herein are neuroprotective molecules containing a sequence of 25-35 contiguous nucleotides that is at least 80% identical to a contiguous sequence between nucleotide 1 and nucleotide 50 of a mature human tRNA and at least four contiguous guanosine-containing nucleotides, where the sequence of 25-35 contiguous nucleotides contains a D-loop... The Brigham And Women s Hospital Inc

10/05/17 / #20170281724

Use of gelsolin to diagnose and treat inflammatory diseases

... The Brigham And Women s Hospital Inc

10/05/17 / #20170283388

14-hydroxy-docosahexaenoic acid compounds

The invention describes novel 14-hydroxy docosahexaenoic acid (DHA) analogues, their preparation, isolation, identification, purification and uses thereof.... The Brigham And Women s Hospital Inc

09/21/17 / #20170266112

Residence structures and related methods

Residence structures, systems, and related methods are generally provided. Certain embodiments comprise administering (e.g., orally) a residence structure to a subject (e.g., a patient) such that the residence structure is retained at a location internal to the subject for a particular amount of time (e.g., at least about 24 hours)... The Brigham And Women s Hospital Inc

09/21/17 / #20170266182

Treatment of igg-immune complex-mediated organ damage

Methods for treating IgG-immune complex-mediated organ damage, e.g., in lupus or Goodpasture syndrome, using Bcr-Abl tyrosine-kinase inhibitors, e.g., Bosutinib.... The Brigham And Women s Hospital Inc

09/21/17 / #20170266660

Methods relating to cryopreservation

The technology described herein is directed to methods of cryopreservation, e.g., cryopreservation in a microfluidics format and methods of utilizing cells preserved by such methods.... The Brigham And Women s Hospital Inc

09/21/17 / #20170266931

Omniphobic materials for bio-applications

Compositions and articles comprising omniphobic materials for bio-related and other applications are generally provided. In some embodiments, the compositions and articles described herein may be introduced internally of a subject (e.g., in the esophagus, in the gastrointestinal tract, in the rectum). In some aspects, the compositions and articles comprise a... The Brigham And Women s Hospital Inc

09/14/17 / #20170258551

Deposition of rfid tags

In a method for printing an RFID tag on an object, a deposition mask is applied to the surface of an object. With the deposition mask on the surface of the object, RFID materials are deposited on at least one portion of the surface exposed by aperture(s) in the deposition... The Brigham And Women s Hospital Inc

08/24/17 / #20170239225

Combination therapies for treatment of spinal muscular atrophy

Disclosed herein are compositions and methods for treatment of spinal muscular atrophy (SMA). In certain embodiments, compounds are provided that increase full-length survival of motor neuron (SMN) protein production by an SMN2 gene.... The Brigham And Women s Hospital Inc

08/17/17 / #20170232138

Elastic biopolymer and use as a tissue adhesive

The present invention provides an improved tissue adhesive to repair defects in soft tissue. Following ASTM standard tests, crosslinked methacryloyl-substituted gelatin hydrogels of the present invention (GelSEAL) were shown to exhibit adhesive properties, i.e. wound closure strength, shear resistance and burst pressure, that were superior to clinically used fibrin- and... The Brigham And Women s Hospital Inc

08/10/17 / #20170226194

Poly-n-acetyl glucosamine (pnag/dpnag)-binding peptides and methods of use thereof

The present invention relates to peptides, particularly human monoclonal antibodies, that bind specifically to poly-N-acetyl glucosamine (PNAG), such as Staphylococcal PNAG, in acetylated, partially acetylated and/or fully deacetylated form. The invention further provides methods for using these peptides in the diagnosis, prophylaxis and therapy of infections by bacteria that express... The Brigham And Women s Hospital Inc

08/10/17 / #20170226477

Compositions and methods for epithelial stem cell expansion and culture

Described are cell culture solutions and systems for epithelial stem cell and organoid cultures, formation of epithelial constructs and uses of the same in transplantation.... The Brigham And Women s Hospital Inc

08/10/17 / #20170226507

Coordinate control of pathogenic signaling by the mir-130/301 family in pulmonary hypertension and fibroproliferative diseases

The present invention relates to methods, kits and compositions to treat hypertension in a subject comprising inhibiting activity or expression of at least one microRNA.... The Brigham And Women s Hospital Inc

08/03/17 / #20170216238

Compounds and methods for modulating vascular injury

Methods of modulating healing response to vascular injury and/or vascular scarring in a subject are provided. As such, aspects of the disclosure relate to the use of pro-resolving lipid mediators to modulate inflammation and/or restenosis of a vascular wall. Another aspect of the disclosure relates to the use of pro-resolving... The Brigham And Women s Hospital Inc

07/27/17 / #20170209529

Fc receptor (fcrn) binding peptides and uses thereof

The invention provided herein includes isolated polypeptides that specifically block the interaction between neonatal Fc receptor (FcRn) and albumin. Blocking the interaction treats diseases and conditions caused by increased amounts of albumin or modified albumin that possesses pathogenic properties wherein it is deemed desirable to decrease albumin levels. Accordingly, also... The Brigham And Women s Hospital Inc

07/27/17 / #20170209601

Biopolymer-nanoparticle composite implant for tumor cell tracking

A method of detecting migration of tumor cells is provided by implanting in a region of tumor cells one or more implants having a matrix material of a biocompatible and biodegradable polymer, and a plurality of nanoparticles dispersed within the matrix material and functionalized to bind tumor cells. Nanoparticles bound... The Brigham And Women s Hospital Inc

07/20/17 / #20170202810

Small molecule inhibitors of usp1 deubiquitinating enzyme activity

Provided are small molecule inhibitors of ubiquitin specific protease 1 (USP1) activity and methods for their use in treating and characterizing cancers. The small molecule USP1 inhibitors of the invention are particularly useful in the treatment of cancers that are resistant to DNA cross-linking agents.... The Brigham And Women s Hospital Inc

07/20/17 / #20170202918

Methods and compositions relating to treatment of pulmonary arterial hypertension

The technology described herein is directed to methods and compositions for the treatment of hypertension, e.g. pulmonary arterial hypertension, relating to inhibition of TGFβ1, TGFβ3, and/or GDF-15.... The Brigham And Women s Hospital Inc

07/06/17 / #20170189483

Diagnostic and therapeutic uses of gelsolin in renal failure

The invention is directed, in part, to the use of gelsolin to diagnose, monitor, and treat subjects with renal failure (e.g., chronic renal failure subjects on dialysis).... The Brigham And Women s Hospital Inc

07/06/17 / #20170192074

Free-breathing non-contrast mr angiography

A system includes a chassis defining a bore, a main magnet to generate a polarizing magnetic field within the bore, a gradient system to apply a gradient magnetic field to the polarizing magnetic field, a radio frequency system to apply an excitation pulse to patient tissue disposed within the bore... The Brigham And Women s Hospital Inc

06/29/17 / #20170184730

Detectors, detecting ionizing radiation using high energy current

Detectors, a system and a method for detecting ionizing radiation are provided. In some aspects, a detector includes a first layer comprising a first conducting material, and a second layer comprising a second conducting material, wherein at least one of the first layer and second layer is configured to produce... The Brigham And Women s Hospital Inc

06/22/17 / #20170173083

Compositions and methods for ex vivo expansion of human hematopoietic stem/progenitor cells

Described herein are methods and compositions which lead to the efficient ex vivo expansion of hematopoietic cells, such as hematopoietic stem cells (HSCs) and hematopoietic stem and progenitor cells HSPCs. Using combinations of small molecule drugs and cytokines/growth factors/grown factors targeting epigenetic status in cells, significant improvements in the expansion... The Brigham And Women s Hospital Inc

06/15/17 / #20170165325

Methods and compositions for the generation and maintenance of regulatory t cells

Methods and compositions for generating and maintaining induced regulatory T cells (iTregs) are provided. Methods and compositions for treating an autoimmune disorder, organ transplant rejection, graft versus host disease or allergic or hypersensitivity and inflammation are also provided.... The Brigham And Women s Hospital Inc

06/08/17 / #20170156310

Platelet additive solution having a beta-galactosidase inhibitor

The present invention relates to a platelet additive solution (PAS) having an amount of one or more β-galactosidase inhibitors with or without an amount of one or more sialidase inhibitors, and optionally one or more glycan-modifying agents; and one or more of PAS components that include a salt, a citrate... The Brigham And Women s Hospital Inc

06/08/17 / #20170157291

Tissue transplant compositions and methods for use

Provided are transplants and methods for augmenting formation and restoration of organ and tissue, for example, bone formation, by administering autologous or allogeneic human embryonic-like adult stem cells (ELA cells). Also provided is a method for augmenting formation of tissues and organs by administering a transplant having ELA stem cells... The Brigham And Women s Hospital Inc

06/08/17 / #20170159016

Selective differentiation, identification, and modulation of human th17 cells

... The Brigham And Women s Hospital Inc

05/18/17 / #20170135954

Self-assembled residence devices and related methods

Residence devices as well as their related methods of manufacture and use are generally provided. In some embodiments, a residence device includes a plurality of self-assembling structures that assemble in vivo to form an aggregate structure. Each structure of the plurality of structures includes a first side and a first... The Brigham And Women s Hospital Inc

05/11/17 / #20170128526

Stem cell derived factors for treating pathologic conditions

A purified paracrine factor of a mesenchymal stem cell, such as a Secreted frizzled related protein (Sfrp) is useful to reduce cell death an/or tissue injury associated with ischemic conditions.... The Brigham And Women s Hospital Inc

05/11/17 / #20170128576

Enteric elastomers

Enteric elastomers and related methods are generally provided. In some embodiments, the enteric elastomer is a polymer composite. Certain embodiments comprise a polymer composite in which hydrogen bonds within two carboxyl group-containing polymers cross-link the polymer networks into an elastic and pH-responsive polymer composite. Advantageously, this polymer composite has the... The Brigham And Women s Hospital Inc

05/04/17 / #20170121318

Use of small molecule inhibitors to klf10 for modulation of t regulatory cells and cancer immunotherapy

The invention relates to compositions and methods for inhibiting Krüppel-like Factor 10 (KLF10) for modulation of T regulatory cells and cancer immunotherapy.... The Brigham And Women s Hospital Inc

05/04/17 / #20170122966

Circulating kim-1 levels for detection of pathologies associated with injury to, or cancer of, the kidney

The present invention is directed to KIM-1 polypeptide as a plasma acute and chronic kidney injury and renal cell carcinoma biomarker, and methods and kits comprising the use of agents specific to KIM-1 for facilitating and enhancing the diagnosis of kidney injury or carcinoma. The present invention is based on... The Brigham And Women s Hospital Inc

04/27/17 / #20170112776

Coated controlled release polymer particles as efficient oral delivery vehicles for biopharmaceuticals

A composition for delivering an active agent to a patient. The composition includes a polymer core encapsulating the active agent and a mucoadhesive coating disposed about the core. The polymer may include covalently linked poly(ethylene glycol) chains, and the mucoadhesive coating may be selected to facilitate transfer of the particle... The Brigham And Women s Hospital Inc

04/20/17 / #20170105998

Metabolically-activated drug conjugates to overcome resistance in cancer therapy

Described are combination therapies and metabolically-activated drug conjugates and their use in treating cancer in subjects.... The Brigham And Women s Hospital Inc

04/20/17 / #20170106099

Residence structures and related methods

Residence structures, systems, and related methods are generally provided. Certain embodiments comprise administering (e.g., orally) a residence structure to a subject (e.g., a patient) such that the residence structure is retained at a location internal to the subject for a particular amount of time (e.g., at least about 24 hours)... The Brigham And Women s Hospital Inc

04/20/17 / #20170107228

Pyrimidine compounds and methods using the same

The present invention relates to 2-amino-4-arylpyrimidine and 2-amino-4-aryltriazine compounds as inhibitors of heat shock protein 90 family of chaperone proteins. The invention also features pharmaceutical compositions and kits that include the compounds and compositions of the invention. The invention further relates to the medical use of these compounds and compositions... The Brigham And Women s Hospital Inc

04/20/17 / #20170107300

Methods and compositions for treatment of immune-related diseases or disorders and/or therapy monitoring

Described herein are methods and compositions for treatment of immune-related diseases or disorders and/or therapy monitoring based on the level of TIGIT, Flg2 and/or IL-33 expression and/or activity. In some embodiments, the methods and compositions described herein are directed to treatment and/or therapy monitoring of cancer and/or infections (e.g., chronic... The Brigham And Women s Hospital Inc

04/20/17 / #20170107556

Diagnosis and treatment of invasive aspergillosis

Methods for diagnosing, treating, and monitoring the treatment of invasive aspergillosis (IA) are described. The methods can include detecting the presence of one or more volatile organic compounds (VOCs) in the breath of subjects suspected of having IA.... The Brigham And Women s Hospital Inc

04/13/17 / #20170100342

Stabilized assembled nanostructures for delivery of encapsulated agents

A non-covalently assembled hydrogel or organo-gel composition with serum stability is described. Low molecular weight (<2,500 Da), generally regarded as safe (GRAS), materials assemble in the presence of a stabilizing agent at an appropriate molar percentage, forming hydrogel or organo-gel with nanostructures that resist disassembly or destabilization in serum for... The Brigham And Women s Hospital Inc

04/13/17 / #20170101451

Protease resistant mutants of stromal cell derived factor-1 in the repair of tissue damage

The present invention is directed stromal cell derived factor-1 peptides that have been mutated to make them resistant to digestion by the proteases dipeptidyl peptidase IV (DPPIV) and matrix metalloproteinase-2 (MMP-2) but which maintain the ability of native SDF-1 to attract T cells. The mutants may be attached to membranes... The Brigham And Women s Hospital Inc

04/06/17 / #20170096707

Methods for diagnosing and assessing risk of developing glomerulosclerosis

This document features method related to variants in the Inverted Formin 2 (INF2) gene that are associated with susceptibility to focal segmental glomerulosclerosis (FSGS). For example, methods of using such variants for risk assessment and for diagnosing and optimizing treatment of FSGS are provided.... The Brigham And Women s Hospital Inc

03/30/17 / #20170088515

Identification of compounds that disperse tdp-43 inclusions

Herein, compounds and compositions for use in treating diseases relating to inclusion formation and stress granules are described. Methods for screening for modulation of TDP-43 aggregation are also described.... The Brigham And Women s Hospital Inc

03/16/17 / #20170071626

Positioning apparatus

A positioning apparatus includes a needle guide, a rotation unit, a detector for the rotation position, a position measuring unit, an engageable stopper, and a setting unit for setting position information to a value corresponding to a predetermined position are provided herewith. The positioning apparatus can be used, for example,... The Brigham And Women s Hospital Inc

03/16/17 / #20170071937

Compositions, systems, and methods for generating inner ear hair cells for treatment of hearing loss

Method and compositions for inducing the self-renewal of stem/progenitor supporting cells comprised by a cochlear cell population, including inducing the stem/progenitor cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into hair cells.... The Brigham And Women s Hospital Inc

03/02/17 / #20170058026

Methods for modulating immune responses during chronic immune conditions by targeting il-27 induced pathways

Described herein are novel compositions comprising IL-27 or NFIL-3 modulators (i e , inhibitors or activators), and methods using these agents for targeting cells, such as functionally exhausted or unresponsive immune cells, and modulating TIM-3 activity or expression. These compositions, methods, and uses are useful for the treatment of chronic... The Brigham And Women s Hospital Inc

02/23/17 / #20170049771

Targeting parp1 for treatment of tsc and cancers

The present invention relates to methods of treating a condition associated with mTORC1 hyperactivation or TSC2-deficient cancer, the method comprising administering to a subject having the cancer a pharmaceutically-effective amount of a poly(ADP-ribose) polymerase 1 (PARP1) inhibitor. In some embodiments, the condition associated with mTORC1 hyperactivation is tuberous sclerosis complex... The Brigham And Women s Hospital Inc

02/23/17 / #20170051099

Polymeric materials for bio-applications

A composition comprising a biodegradable polymeric material and therapeutic agent associated with the polymeric material that advantageously can provide controlled release of the therapeutic agent, while comprising little to no auxiliary materials. In some embodiments, the composition is formed by the reaction of one or more monomers in the presence... The Brigham And Women s Hospital Inc

02/16/17 / #20170042870

Targeted nanoparticle compositions and methods of their use to treat obesity

Nanoparticles having a positive feedback delivery system include an agent specific for a target in combination with a target inducing agent. Upon administration to a subject, the targeting moiety on the nanoparticles binds to available targets in the subject. The nanoparticles release the target inducing agent and, optionally, a therapeutic... The Brigham And Women s Hospital Inc

02/16/17 / #20170044257

Methods to manipulate alpha-fetoprotein (afp)

As demonstrated herein, soluble human FcRn binds to AFP with affinities greater than observed with albumin, and is able to interfere with FcRn-mediated protection of and functional associations with IgG. Accordingly, provided herein, in some aspects, are compositions and methods to inhibit FcRn and AFP interactions in diseases or disorders... The Brigham And Women s Hospital Inc

02/16/17 / #20170045528

Compositions and methods for treating subjects with immune-mediated diseases

Described herein are methods, assays and systems for selecting subjects with immune-mediated diseases who would optimally respond to anti-FcRn therapies and administering effective amounts of compositions comprising anti-FcRn agents for treating, inhibiting and/or reducing the symptoms of immune-mediated diseases in subjects.... The Brigham And Women s Hospital Inc

02/09/17 / #20170035891

Drug delivery composition comprising a self-assembled gelator

This invention discloses drug-delivery compositions, methods of making prodrugs, and methods of drug delivery using a self-assembled gelator. The backbone of the gelator can contain a drug or prodrug, such as acetaminophen or salicin. Additional drugs or agents can be encapsulated in the gelator. Enzymatic or hydrolytic cleavage can be... The Brigham And Women s Hospital Inc

02/09/17 / #20170037472

Methods for the treatment of kidney fibrosis

The technology described herein is directed to the diagnosis, prognosis, and treatment of kidney fibrosis, e.g., chronic kidney disease.... The Brigham And Women s Hospital Inc

02/09/17 / #20170037478

Methods for predicting anti-cancer response

The present invention is based, in part, on the identification of novel methods for defining predictive biomarkers of response to anti-cancer drugs.... The Brigham And Women s Hospital Inc

02/02/17 / #20170028058

Herpes simplex virus vaccines

The present invention is directed to Herpes simplex-2 viruses that may be used in vaccines to immunize patients against genital herpes.... The Brigham And Women s Hospital Inc

02/02/17 / #20170029904

Classification of myc-driven b-cell lymphomas

Methods for diagnosing Burkitt lymphoma (BL) and diffuse large B-cell lymphoma (DLBCL) based on a diagnostic score, as well as determining MYC activity levels and selecting treatments based on a MYC activity score.... The Brigham And Women s Hospital Inc

01/19/17 / #20170014200

Medical support device

There is provided a medical support device for holding and positioning a needle. This device is particularly useful for positioning needles in a less invasive puncture treatment. This device comprises two rotational elements and at least one needle guide attached to a rotational element and. The needle guide guides the... The Brigham And Women s Hospital Inc

01/19/17 / #20170015726

Targeted therapeutics

The present invention relates to compositions, methods and kits for delivery of active agents (X) to cells or tissues that express proteoglycans. More specifically, the present invention relates to conjugates comprising (HB-linker)n-Xm-(linker-HB)o, where HB is a heparin binding protein, X is an active agent such as a therapeutic protein (including... The Brigham And Women s Hospital Inc

01/19/17 / #20170015757

Anti-fibulin-3 antibodies and uses thereof

Embodiments described herein provide anti-fibulin-3 antibodies, recombinant proteins that bind specifically to fibulin-3, compositions and the treatment methods comprising these antibodies and recombinant proteins.... The Brigham And Women s Hospital Inc

01/12/17 / #20170007595

Nsd3 inhibitors for treatment of cancers

The present invention relates to the use of NSD3i inhibitors for the treatment of cancer. In particular, the present invention relates to methods, kits and compositions comprising NSD3 inhibitors to treat cancers dependent on NSD3, in particular subjects with NUT midline carcinoma (NMC) and subjects with NSD3/NUT or BRD4/NUT or... The Brigham And Women s Hospital Inc

01/05/17 / #20170000581

Fiducial markers, systems, and methods of registration

Exemplary methods, apparatus, and systems are provided for automated detection and registration of medical images using fiducial markers and processing algorithms. By either clustering fiducial markers having a different number, size, shape, configuration, or material property or by using fiducial markers arranged in a ring shape, wherein their arrangement is... The Brigham And Women s Hospital Inc

01/05/17 / #20170000888

Nanostructured gels capable of controlled release of entrapped agents

Self-assembled gel compositions including a gelator, e.g., an enzyme-cleavable gelator, e.g., having a molecular weight of 2500 or less, are described. The self-assembled gel compositions can encapsulate one or more agents. Methods of making the self-assembled gel compositions, and methods of drug delivery using the self-assembled gel compositions are also... The Brigham And Women s Hospital Inc

01/05/17 / #20170000899

Receptor-targeted nanoparticles for enhanced transcytosis mediated drug delivery

Receptor-targeted nanoparticles (R-NPs) are provided for selective transport into and through targeted tissues of therapeutic, prophylactic and diagnostic agents. R-NPs can include polymeric particle, lipid particles, inorganic particles, or a combination thereof with a targeting moiety selective for binding to a receptor on the cells where the agent is to... The Brigham And Women s Hospital Inc

01/05/17 / #20170002073

Compositions and methods for modulating an immune response

Described herein are compositions for increasing IL-12 production comprising IgG or a fragment thereof or a variant thereof and uses of said compositions for treating cancer and infectious diseases. Also described herein are compositions for decreasing IL-12 production comprising an agent that inhibits signaling mediated by interaction between FcRn and... The Brigham And Women s Hospital Inc

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