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The Children s Hospital Of Philadelphia
The Children s Hospital Of Philadelphia On Behalf Of Children s Oncology Group

The Children s Hospital Of Philadelphia patents


Recent patent applications related to The Children s Hospital Of Philadelphia. The Children s Hospital Of Philadelphia is listed as an Agent/Assignee. Note: The Children s Hospital Of Philadelphia may have other listings under different names/spellings. We're not affiliated with The Children s Hospital Of Philadelphia, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "T" | The Children s Hospital Of Philadelphia-related inventors


Compositions and methods for the treatment of fatty acid metabolism disorders

Compositions and methods for inhibiting, treating, and/or preventing fatty acid metabolism disorders, particularly fatty acid oxidation disorders, in a subject are provided.... The Children s Hospital Of Philadelphia

Compositions and methods for the diagnosis and treatment of lupus nephritis

Compositions and methods for diagnosing and treating lupus nephritis are disclosed.... The Children s Hospital Of Philadelphia

Controlled gene expression methods

Methods and compositions for controlling gene expression are disclosed.... The Children s Hospital Of Philadelphia

Viral vectors for prophylaxis and therapy of hemoglobinopathies

Provided are compositions and methods for inducing expression of human beta-globin in erythrocytes for use in prophylaxis and/or therapy of a hemoglobinopathy in an individual. The method generally entails introducing into CD34+ cells a polynucleotide encoding: i) a 5′ long terminal repeat (LTR) and a self-inactivating 3′ LTR; ii) at... The Children s Hospital Of Philadelphia

Scalable manufacturing process to produce recombinant lentiviral vectors in serum-free suspension cell culture system

Methods for preparing highly purified rLV vector formulations at the scale needed to meet anticipated demand for human gene therapy are provided.... The Children s Hospital Of Philadelphia

Compositions and methods for enhancing coagulation factor viii function

Factor VIII variants and methods of use thereof are disclosed.... The Children s Hospital Of Philadelphia

Apparatus and methods for testing visual function and functional vision at varying luminance levels

A test of visual function and/or functional vision may be performed at varying luminance levels. A first course may be selected for a subject. A given course may comprise a layout having a beginning point, at least one turn, at least one obstacle, and an ending point. The first course... The Children s Hospital Of Philadelphia

Compositions and methods for modulating hemostasis

Factor X/Xa variants and methods of use thereof are disclosed.... The Children s Hospital Of Philadelphia

Compositions and methods for treating b-lymphoid malignancies

Compositions and methods for inhibiting, treating, and/or preventing a B-cell neoplasm are provided.... The Children s Hospital Of Philadelphia

An improved expression cassette for packaging and expression of variant factor viii for the treatment of hemostasis disorders

Factor VIII variants and methods of use thereof are disclosed. In particular embodiments, Factor VIII variants are expressed more efficiently by cells over wild-type Factor VIII proteins, are secreted at increased levels by cells over wild-type Factor VIII proteins, exhibit enhanced activity over wild-type Factor VIII proteins and are packaged... The Children s Hospital Of Philadelphia

Devices and methods for alleviating lymphatic system congestion

The presently disclosed subject matter relates to methods and devices for decompressing the lymphatic system. In particular, the present disclosure provides devices for actively or passively decompressing the lymphatic system and methods of their use and deployment within a subject. In certain non-limiting embodiments, a device of the present disclosure... The Children s Hospital Of Philadelphia

Humanized viral vectors and methods of use thereof

The present invention provides humanized viral vectors and methods of use thereof for delivery of transgenes or therapeutic nucleic acids to human subjects. Humanized viral vectors are modified from known viral vectors such as those based on AAV by coating their surface with a human protein such as human serum... The Children s Hospital Of Philadelphia

Nonselective metabotropic glutamate receptor activators for treatment of attention deficit disorder and 22q syndrome

This application relates to methods of treating attention deficit hyperactivity disorder (ADHD), 22q deletion and/or duplication syndrome, and co-morbidities with a nonselective activator of metabotropic glutamate receptors, such as fasoracetam, for example, in subjects having a genetic alteration in at least one metabotropic glutamate receptor (mGluR) network gene.... The Children s Hospital Of Philadelphia

Methods of diagnosing and treating tourette syndrome

Methods and uses for diagnosing and treating Tourette syndrome are encompassed, wherein diagnosis and treatment may be based upon an assessment of genetic alterations metabotropic glutamate receptor (mGluR) network genes and Wherein treatment with nonspecific activators of mGluRs such as fasoracetam.... The Children s Hospital Of Philadelphia

Methods of diagnosing and treating conduct disorder

Methods for diagnosing and treating conduct disorder are encompassed, wherein diagnosis and treatment may be based upon an assessment of genetic alterations in metabotropic glutamate receptor (mGluR) network genes and wherein treatment is with nonspecific activators of mGluRs such as fasoracetam.... The Children s Hospital Of Philadelphia

Methods of diagnosing and treating anxiety disorder

Methods and uses for diagnosing and treating anxiety disorders are encompassed, wherein diagnosis and treatment may be based upon an assessment of genetic alterations in metabotropic glutamate receptor (mGluR) network genes and wherein treatment is with nonspecific activators of mGluRs such as fasoracetam.... The Children s Hospital Of Philadelphia

Methods of diagnosing and treating autism

Methods for diagnosing and treating autism spectral disorders are encompassed. In one embodiment, a patient is diagnosed as having autism spectral disorder if at least one CNV in an mGluR network gene is found in a patient sample. Patients with at least one mGluR network gene CNV are effectively treated... The Children s Hospital Of Philadelphia

Methods for managing care of patients predisposed to progressive mitral valve diseases

The present invention relates to methods for treating or preventing a mitral valve disease in a subject in need thereof, comprising administering to the subject an effective amount of a therapeutic agent. The therapeutic agent is capable of suppressing serotonin receptor signaling. The methods may be combined with a mitral... The Children s Hospital Of Philadelphia

Compositions and methods for use in combination for the treatment and diagnosis of autoimmune diseases

This disclosure provides new genetic targets, diagnostic methods, and therapeutic treatment regimens for multiple autoimmune disorders, including pediatric autoimmune disorders that are co-inherited and genetically shared. The disclosure, for example, provides methods of diagnosing or determining a susceptibility for one or more autoimmune diseases and methods of determining treatment protocols... The Children s Hospital Of Philadelphia

Methods of treating autoimmune conditions in patients with genetic variations in dcr3 or in a dcr3 network gene

The present disclosure relates to methods of treating autoimmune conditions in patients who have genetic alterations in the TNFRSF6B gene, which codes for the decoy receptor 3 protein (DcR3), for example that reduce the expression, secretion, or ligand binding activity of DcR3. For example, in some embodiments, the conditions may... The Children s Hospital Of Philadelphia

System and local delivery of therapeutic compounds

An apparatus for preloading magnetic particles or cells onto a medical device includes a device carrier and a particle carrier attached over the device carrier. At least one magnet is inserted into the device carrier, the at least one magnet extending inside a section of the device carrier, over which... The Children s Hospital Of Philadelphia

Genetic alterations on chromosome 16 and methods of use thereof for the diagnosis and treatment of type 1 diabetes

Compositions and methods for the detection and treatment of T1D are provided.... The Children s Hospital Of Philadelphia

Compositions and methods for treating cytokine-related disorders

Compositions and methods for treating a cytokine release syndrome such as chimeric antigen receptor T-cell cytokine release syndrome or hemophagocytic lymphohistiocytosis are provided.... The Children s Hospital Of Philadelphia

Association of rare recurrent genetic variations to attention-deficit, hyperactivity disorder (adhd) and methods of use thereof for the diagnosis and treatment of the same

Compositions and methods for the detection and treatment of ADHD are provided.... The Children s Hospital Of Philadelphia

Gene expression signatures for detection of underlying philadelphia chromosome-like (ph-like) events and therapeutic targeting in leukemia

The invention provides arrays, systems, devices, methods, computer-readable media and kits that enable expression-based classification of B-precursor acute lymphoblastic leukemia (ALL) as being either responsive or non-responsive to tyrosine kinase inhibitor mono or co-therapy.... The Children s Hospital Of Philadelphia








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