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The Chinese University Of Hong Kong patents


Recent patent applications related to The Chinese University Of Hong Kong. The Chinese University Of Hong Kong is listed as an Agent/Assignee. Note: The Chinese University Of Hong Kong may have other listings under different names/spellings. We're not affiliated with The Chinese University Of Hong Kong, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "T" | The Chinese University Of Hong Kong-related inventors


 new patent  Universal haplotype-based noninvasive prenatal testing for single gene diseases

To detect a fetal mutation inherited from the mother without paternal genetic information, a property of each maternal haplotype can be measured in the cell-free mixture. A separation value between values of the property for the two maternal haplotypes can be compared to thresholds to determine which haplotype is inherited. ... The Chinese University Of Hong Kong

Novel compounds for treating diabetes

The present invention provides a class of novel aryl pseudo-c-glycoside compounds that are effective for treating diabetes. Also provided are methods for making such compounds and methods for treating diabetes by administering such compounds to patients who have been diagnosed with diabetes or are at risk of developing diabetes.. ... The Chinese University Of Hong Kong

Air quality measurement with modular sensor system and method

An apparatus for acquiring air quality data from removable and/or replaceable sensor, processing and storing the acquired data, and transmitting the processed data to backend server is enabled. The apparatus includes a microcontroller coupled with a universal sensor interface (usi). ... The Chinese University Of Hong Kong

Antenna assembly and self-curing decoupling method for reducing mutual coupling of coupled antennas

The disclosure provides antenna assemblies and methods for reducing mutual coupling of coupled antennas. According to an embodiment, the antenna assembly, comprises: a first antenna; and a second antenna coupled with the first antenna; wherein a first capacitive load is provided to the first antenna at a first position of the first antenna so that a mutual coupling between the first antenna and the second antenna is reduced. ... The Chinese University Of Hong Kong

Non-invasive determination of methylome of fetus or tumor from plasma

Systems, methods, and apparatuses can determine and use methylation profiles of various tissues and samples. Examples are provided. ... The Chinese University Of Hong Kong

Gestational age assessment by methylation and size profiling of maternal plasma dna

Temporal variations in one or more characteristics measured from a cell-free dna sample are used to estimate a gestational age of a fetus. Example characteristics include the methylation level measured from the cell-free dna sample, size of dna fragments measured from the cell-free dna sample (e.g., proportion of fetal-derived dna fragments longer than a specified size), and ending patterns of the dna fragments align to a reference genome.. ... The Chinese University Of Hong Kong

Wearable and unobtrusive multi-sensor array and method for pulse wave velocity imaging

Novel and advantageous systems, devices, and methods for pulse wave velocity (pwv) imaging that enable precise central blood pressure (bp) estimation are provided. A multi-sensor array can provide two-dimensional pwv, thereby achieving the pwv imaging and precise central bp estimation. ... The Chinese University Of Hong Kong

Ankle-foot prosthesis device

A powered ankle-foot prosthesis and associated methods of use are described herein. Such prostheses can employ an actuator and elastic components, the actuator being controlled to deliver net positive work to propel the wearing amputee forward and the elastic components being used to store and release negative energy to improve efficiency. ... The Chinese University Of Hong Kong

Highly specific delivery of polynucleotides to the cell nucleus via compression

The subject invention pertains to delivering a polynucleotide into a target cell, particularly, into the nucleus of the target cell. The method comprises the steps of contacting the polynucleotide with the cell and applying pressure on the polynucleotide and the cell in a manner that forces the polynucleotide into the cell. ... The Chinese University Of Hong Kong

3d building extraction apparatus, method and system

Disclosed is a method for 3d building extraction, comprising: extracting building footprints from one or more stereo images for a building; determining, from rational polynomial coefficient of the stereo images, first height estimation of the extracted building footprints; obtaining, from multi-temporal sar images for the building, scatters with stable attributes; determining second height estimation for the determined scatters; and combining the first height estimation and the second height estimation to generate a fused height for each of the extracted building footprints.. . ... The Chinese University Of Hong Kong

System and method for continuous wave constant amplitude on-resonance and off-resonance spin-lock for magnetic resonance imaging

Mri techniques provide robust imaging in the presence of inhomogeneity in the b1 (rf) and/or b0 magnetic fields. The techniques include using a magnetization prep sequence that includes an adiabatic half passage (ahp) followed by a spin-lock pulse, followed by a reverse ahp, after which a data acquisition sequence can be applied. ... The Chinese University Of Hong Kong

Phonetic posteriorgrams for many-to-one voice conversion

A method for converting speech using phonetic posteriorgrams (ppgs). A target speech is obtained and a ppg is generated based on acoustic features of the target speech. ... The Chinese University Of Hong Kong

Method and apparatus for structural coloration of metallic surfaces

Materials for, and methods of, colorizing a metallic surface with micro-gratings using vibration cutting technologies are provided. Micro-gratings on aluminum, brass, and stainless steel surfaces can be rapidly created to effect, under illumination, at least one color observable in the visible spectrum using elliptical vibration texturing, a vibration-assisted mechanical cutting process. ... The Chinese University Of Hong Kong

Phenothiazine-pyridine compounds and uses thereof

The present invention provides a novel phenothiazine-pyridine compound that is an effective photosensitizer useful for photodynamic therapy. Also provided is a method for inhibiting cell proliferation or for treating a disease involving inappropriate cell proliferation.. ... The Chinese University Of Hong Kong

01/04/18 / #20180000725

Orally-dissolving films for drug delivery through the oral cavity

Orally dissolving films including a pharmaceutically active ingredient having a low bioavailability due to first-pass metabolism and/or low water solubility upon oral administration and a pharmaceutically acceptable excipient, and a medical application thereof.. . ... The Chinese University Of Hong Kong

12/07/17 / #20170349948

Detecting hematological disorders using cell-free dna in blood

Techniques are provided for detecting hematological disorders using cell-free dna in a blood sample, e.g., using plasma or serum. For example, an assay can target one or more differentially-methylated regions specific to a particular hematological cell lineage (e.g., erythroblasts). ... The Chinese University Of Hong Kong

11/30/17 / #20170346179

Apparatus and methods for reducing mutual couplings in an antenna array

A device is presented for improving radio frequency (rf) and microwave array antenna performance. The device sits in the near field, the reactive region, of the antenna array with a pattern of electrically isolated rectangular, cross-shaped, ell, and/or similarly-shaped patches of flat metal or other conductor in a flat plane. ... The Chinese University Of Hong Kong

11/30/17 / #20170345989

Methods of fabrication of flexible micro-thermoelectric generators

A cross-plane flexible micro-teg with hundreds of pairs of thermoelectric pillars formed via electroplating, microfabrication, and substrate transferring processes is provided herein. Typically, fabrication is conducted on a si substrate, which can be easily realized by commercial production line. ... The Chinese University Of Hong Kong

11/16/17 / #20170329127

Light modulator using total internal reflection at an interface with a tunable conductive layer

A light modulator (e.g., for terahertz radiation) may be constructed using a prism in which light undergoes total internal reflection (tir) at one surface. A tunable conductive layer is disposed on the tir surface. ... The Chinese University Of Hong Kong

11/09/17 / #20170319553

Novel polymorph of itraconazole with improved pharmaceutical properties

The present invention provides a new crystalline form of itraconazole as well as the method of making same.. . ... The Chinese University Of Hong Kong

10/12/17 / #20170292935

Evanescent-wave quartz-enhanced photoacoustic sensor with resonator elements

A novel evanescent-wave quartz-enhanced optical microfiber photoacoustic gas sensor is provided for detecting trace amounts of gas. Both fiber-taper based evanescent field and photoacoustic spectroscopy can be used to exploit the merits of both technologies. ... The Chinese University Of Hong Kong

10/05/17 / #20170283876

Biomarker rnf6 for colorectal cancer

The present invention provides a method for diagnosing of colorectal cancer in a subject and a method for determining risk of recurrence of colorectal cancer among colorectal cancer patients by detecting overexpression of the rnf6 gene, which in some cases is due to a higher than normal copy number of the genomic sequence of this gene. A kit and device useful for such methods are also provided. ... The Chinese University Of Hong Kong

10/05/17 / #20170283875

Biomarker foxf2 for gastric cancer

The present invention provides a method for diagnosing and determining prognosis of gastric cancer in a subject by detecting suppressed expression of the foxf2 gene, which in some cases is due to elevated methylation level in the genomic sequence of this gene. A kit and device useful for such a method are also provided. ... The Chinese University Of Hong Kong

10/05/17 / #20170281591

Prodrug of green tea epigallocatechin-3-gallate (pro-egcg) for use in the treatment of endometriosis

Method of treating endometriosis and related indications, comprising the administration of pro-egcg, a synthetic and derivative product of epigallocatechin-3-gallate [(−)-egcg]. Use of pro-egcg in the manufacture of a medicament for treating endometriosis and related indications. ... The Chinese University Of Hong Kong

09/28/17 / #20170278244

Method and a system for non-rigid image registration

Disclosed is a method for non-rigid image registration, comprising: dividing a subject image and a target image into a plurality of subject sub-images and a plurality of target sub-images, respectively; registering, in parallel, each of the subject sub-images and the corresponding one of the target sub-images to obtain a transformation matrix of the each of the subject sub-images relative to the corresponding one of the target sub-images; transforming, based on by the obtained transformation matrices, the subject sub-images into images corresponding to the target sub-images; and merging the transformed images to form a final registered image having the resolution of the target image. A system and a device for non-rigid image registration are also enclosed within the disclosure.. ... The Chinese University Of Hong Kong

09/28/17 / #20170273552

Visual disability detection system using virtual reality

Techniques for a visual disability detection system that employs virtual reality to assess visual performance of a patient based on activities of daily living are described. The virtual reality platform can integrate the testing of different components of visual function based on activities of daily living to provide a direct and clinically relevant measure of the impact of any visual disability on a patient's daily life. ... The Chinese University Of Hong Kong

09/21/17 / #20170268062

Biomarker scnn1b for gastric cancer

The present invention provides a method for diagnosing and determining prognosis of gastric cancer in a subject by detecting suppressed expression of the scnn1b gene, which in some cases is due to elevated methylation level in the genomic sequence of this gene. A kit and device useful for such a method are also provided. ... The Chinese University Of Hong Kong

09/14/17 / #20170262611

Modeling method for orthopedic casts

A computer-implemented method for modeling an orthopedic cast, including scanning an injured limb to extract raw body data; determining, from the extracted raw body data, a target portion data of the injured limb, the determined data representing a fine cast surface for the orthopedic cast; patterning the fine cast surface to form a ventilation structure and a blank area thereon; forming an opening gap on the blank area for assembling and disassembling the orthopedic cast; and offsetting the cast surface in parallel to thicken the orthopedic cast.. . ... The Chinese University Of Hong Kong

08/24/17 / #20170243097

Method and apparatus for decoding or generating multi-layer color or code, method for recommending setting parameters in generation of multi-layer or code, and product comprising multi-layer color or code

The present invention discloses a system and a method for decoding qr codes in complex scenes, a system and a method for generating multi-layer color qr codes and applications enabled by the systems and methods. The method for decoding a qr code may include detecting rough locations of the qr code by a learning-based qr code detector which is pre-trained off-line; localizing finder patterns and alignment patterns within each detected location; correcting geometric distortion of each qr code, based on the localized finder patterns and alignment patterns; restoring a color of each data module within each corrected qr code by a learning-based classifier; and decoding the qr code from each restored qr code. ... The Chinese University Of Hong Kong

08/17/17 / #20170235877

Size-based analysis of tumor dna

A classification of a level of cancer in an organism is determined by analyzing a biological sample of the organism. The biological sample comprises clinically-relevant dna and other dna. ... The Chinese University Of Hong Kong

08/17/17 / #20170233829

Detecting chromosomal aberrations associated with cancer using genomic sequencing

Methods, systems, and apparatus determine whether a first chromosomal region exhibits a deletion or an amplification associated with cancer in a sample from a subject (e.g., where the sample includes a mixture of cell-free dna from tumor cells and non-malignant cells. Nucleic acid molecules of the biological sample are sequenced. ... The Chinese University Of Hong Kong

08/17/17 / #20170233442

Peptidylyic inhibitor targeting cag-repeat rna toxicity in polyglutamine diseases

The present invention provides for a novel peptide and method for treating polyglutamine (polyq) diseases. Also disclosed are related compositions and kits for therapeutic use in the treatment of polyq diseases.. ... The Chinese University Of Hong Kong

08/03/17 / #20170220736

Determining progress of chromosomal aberrations over time

Systems, apparatus, and methods are provided for determining aberrations in a biological sample from an organism. Biological samples including cell-free dna fragments are analyzed to identify imbalances in chromosomal regions, e.g., due to deletions and/or amplifications in a tumor. ... The Chinese University Of Hong Kong

08/03/17 / #20170218450

Detecting genetic aberrations associated with cancer using genomic sequencing

Methods, systems, and apparatus determine whether a first chromosomal region exhibits a deletion or an amplification associated with cancer in a sample from a subject (e.g., where the sample includes a mixture of cell-free dna from tumor cells and non-malignant cells. Nucleic acid molecules of the biological sample are sequenced. ... The Chinese University Of Hong Kong

07/20/17 / #20170204161

Fast and efficient conjugation method based on thiourea-catechol coupling

The present invention provides novel methods and compositions useful for a fast and efficient chemical conjugation method of making hetero-arm polymers based on thiourea-catechol coupling. This novel conjugation method are useful in a wide variety of applications relating to the modification, ligation, and conjugation of large or small molecules to each other as well as to solid surface, including the making of adhesive materials such as hydrogels.. ... The Chinese University Of Hong Kong

07/13/17 / #20170198302

Methods and systems for targeted gene manipulation

The present invention provides novel methods and systems, including cell lines, recombinant polynucleotide constructs, compositions, and kits, for targeted yet universal genomic manipulation.. . ... The Chinese University Of Hong Kong

07/13/17 / #20170196998

Nanoparticle contrast agent for early diagnosis of alzheimer's disease by magnetic resonance imaging (mri)

The disclosure herein relates to a novel nanoparticle that can cross the blood-brain barrier and form a bond with amyloid plaques and other related protein aggregates for detection by magnetic resonance imaging (mri). The compositions, methods of making, and methods of use set forth herein also provide a non-invasive means for diagnosing alzheimer's disease at an early stage.. ... The Chinese University Of Hong Kong

07/06/17 / #20170195914

Hardware acceleration for batched sparse codes

Hardware acceleration for batched sparse (bats) codes is enabled. Hardware implementation of some timing-critical procedures can effectively offload computationally intensive overheads, for example, finite field arithmetic, gaussian elimination, and belief propagation (bp) calculations, and this can be done without direct mapping of software codes to a hardware implementation. ... The Chinese University Of Hong Kong

06/29/17 / #20170181986

Small molecule inhibitors targeting cag-repeat rna toxicity in polyglutamine diseases

The present invention provides for a novel method for treating polyglutamine (polyq) diseases. Also disclosed are related compositions and kits for therapeutic use in the treatment of polyq diseases.. ... The Chinese University Of Hong Kong

06/22/17 / #20170175195

Methods for assessing liver pathologies

The present invention provides a new method for detecting or monitoring a liver disease in a subject that has no indication of any liver pathologies, by measuring the amount of concentration of albumin mrna in an acellular blood sample from the subject, and then comparing the amount or concentration of albumin mrna with a standard control.. . ... The Chinese University Of Hong Kong

06/22/17 / #20170172430

Method for measuring cardiovascular and respiratory parameters based on multi-wavelength photoplethysmography

Accurate and effective methods for measuring cardiovascular and respiratory parameters are provided. The method for deriving a depth-specific photoplethysmography (ppg) signal from multi-wavelength ppg signals includes choosing light wavelength combinations, calibrating a multi-layer light-tissue interaction model referring to a physiological signal, and generating the depth-specific ppg signal from the multi-wavelength ppg signals based on the calibrated light-tissue interaction model. ... The Chinese University Of Hong Kong

06/08/17 / #20170162900

High-energy density and low-cost flow electrochemical devices

The invention provides novel high-energy density and low-cost flow electrochemical devices incorporating solid-flow electrodes, and further provides methods of using such electrochemical devices. Included are anode and cathode current collector foils that can be made to move during discharge or recharge of the device. ... The Chinese University Of Hong Kong

06/01/17 / #20170151327

Induction of immunotolerance

The present invention provides for a novel method for inhibiting an undesirable immune response, especially in transplant recipients such as those having received an allogeneic stem cell transplant. Also disclosed are related compositions and kits for inducing immunotolerance.. ... The Chinese University Of Hong Kong

05/11/17 / #20170132363

Size-based analysis of tumor dna

A classification of a level of cancer in an organism is determined by analyzing a biological sample of the organism. The biological sample comprises clinically-relevant dna and other dna. ... The Chinese University Of Hong Kong

04/27/17 / #20170114396

Detecting bacterial taxa for predicting adverse pregnancy outcomes

It provides a method for predicting the risk of an adverse pregnancy or neonatal outcome for a pregnant subject by detecting the elevated level of bacteria from one or more selected bacterial taxa (e.g., genera or species). A kit useful for such a method is also provided. ... The Chinese University Of Hong Kong

04/13/17 / #the present invention concerns a method for the detection or monitoring of cancer using a biological sample selected from blood, plasma, serum, saliva, urine from an individual, said method comprising:

The Chinese University Of Hong Kong

. . ... The Chinese University Of Hong Kong

03/30/17 / #20170093666

Loss-resilient protocols for communication networks

Bats protocols may be utilized for high efficiency communication in networks with burst or dependent type losses. Systematic recoding at intermediate network nodes may be utilized to reduce the computational cost during recoding. ... The Chinese University Of Hong Kong

03/23/17 / #20170082845

High-speed binary laser beam shaping and scanning

A device for shaping and scanning an ultrafast laser beam including a laser source configured to output a pulsed laser beam containing different frequency spectrum; a digital micromirror device (dmd) consisting of a plurality of micromirrors, configured to receive the laser beam and shape the received laser beam with a first angular dispersion; and a dispersion compensation unit, arranged before or after the dmd, configured to transfer the laser beam from the laser source to the dmd with a second angular dispersion for neutralizing the first angular dispersion.. . ... The Chinese University Of Hong Kong

03/23/17 / #20170081720

Accurate deduction of fetal dna fraction with shallow-depth sequencing of maternal plasma

Embodiments of the present invention provide methods, systems, and apparatus for deducing the fetal dna fraction in maternal plasma without using paternal or fetal genotypes. Maternal genotype information may be obtained from a maternal-only dna sample or may be assumed from shallow-depth sequencing of a biological sample having both maternal and fetal dna molecules. ... The Chinese University Of Hong Kong

03/16/17 / #20170077665

Diamond maser and microwave amplifier

Masers and microwave amplifiers that can function in the continuous-wave mode at room temperature are provided. The maser system can include a diamond gain medium having nitrogen-vacancy centers, and a resonator can be disposed around the gain medium. ... The Chinese University Of Hong Kong

03/16/17 / #20170073774

Detecting mutations for cancer screening and fetal analysis

Embodiments are related to the accurate detection of somatic mutations in the plasma (or other samples containing cell-free dna) of cancer patients and for subjects being screened for cancer. The detection of these molecular markers would be useful for the screening, detection, monitoring, management, and prognostication of cancer patients. ... The Chinese University Of Hong Kong

03/02/17 / #20170064701

Message coding for ncma-based multiple access networks

Computationally efficient message encoding and decoding schemes for ncma-based multiple access networks are enabled. Belief propagation decoding of fountain codes designed for ncma-based multiple access networks may be enhanced using gaussian elimination. ... The Chinese University Of Hong Kong

03/02/17 / #20170062933

Air-filled patch antenna

Disclosed is an air-filled patch antenna, comprising: a ground plane; a patch arranged to be in parallel to the ground plane; four inherent metal legs extending from the patch perpendicularly, wherein each of distal ends of the four legs is electrically and mechanically connected to the ground plane; and a feeding structure configured to provide a signal interface to the antenna.. . ... The Chinese University Of Hong Kong

02/16/17 / #20170044606

Single-molecule sequencing of plasma dna

Embodiments may include a method of determining a nucleic acid sequence. The method may include receiving a plurality of dna fragments. ... The Chinese University Of Hong Kong

02/16/17 / #20170042989

Photosensitized trypanosomatids and vaccine compositions thereof

Disclosed herein are methods and compositions for the delivery of polypeptides, including vaccine candidate polypeptides, into mammalian cells comprising the use of photosensitized trypanosomatid organisms. Also disclosed are methods of treatment of trypanosomatid infections comprising administering phthalocyanine compounds or phthalocyanine-treated trypanosomatid microorganisms as vaccines, as well as and polypeptide delivery vectors comprising phthalocyanine-treated trypanosomatid microorganisms.. ... The Chinese University Of Hong Kong

02/02/17 / #20170029900

Methylation pattern analysis of haplotypes in tissues in a dna mixture

Systems, apparatuses, and method are provided for determining the contributions of different tissues to a biological sample that includes a mixture of cell-free dna molecules from various tissues types, e.g., as occurs in plasma or serum and other body fluids. Embodiments can analyze the methylation patterns of the dna mixture (e.g., methylation levels at particular loci) for a particular haplotype and determine fractional contributions of various tissue types to the dna mixture, e.g., of fetal tissue types or tissue types of specific organs that might have a tumor. ... The Chinese University Of Hong Kong

01/26/17 / #20170024513

Analysis of fragmentation patterns of cell-free dna

Factors affecting the fragmentation pattern of cell-free dna (e.g., plasma dna) and the applications, including those in molecular diagnostics, of the analysis of cell-free dna fragmentation patterns are described. Various applications can use a property of a fragmentation pattern to determine a proportional contribution of a particular tissue type, to determine a genotype of a particular tissue type (e.g., fetal tissue in a maternal sample or tumor tissue in a sample from a cancer patient), and/or to identify preferred ending positions for a particular tissue type, which may then be used to determine a proportional contribution of a particular tissue type.. ... The Chinese University Of Hong Kong

01/19/17 / #20170017202

Devices and methods for holographic 3d imaging

A device, system and method for holographic 3d imaging. The device includes a laser light source that delivers a laser beam; an aperture disc including at least two pinholes, the laser beam being filtered by the pinholes so that a reference wave and an object wave are generated; a sample having a first area containing an object to be imaged and a second area without any object, in which the first area and the second area are illuminated by the object wave and the reference wave respectively; and an image sensor that captures an off-axis hologram for reconstructing an image of the object, in which the reference wave and the object wave are interfered on the image sensor and the hologram is captured based on an interference pattern of the reference wave and the object wave.. ... The Chinese University Of Hong Kong








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