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The Chinese University Of Hong Kong
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The Chinese University Of Hong Kong patents


Recent patent applications related to The Chinese University Of Hong Kong. The Chinese University Of Hong Kong is listed as an Agent/Assignee. Note: The Chinese University Of Hong Kong may have other listings under different names/spellings. We're not affiliated with The Chinese University Of Hong Kong, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "T" | The Chinese University Of Hong Kong-related inventors


Method for producing knee replacement implant and implant for knee replacement

The present application discloses a method of producing a knee replacement implant, an implant for knee replacement formed by using the method, and a knee replacement implant. The method includes: defining a hip center, a knee center, an ankle center and a posterior femoral condylar axis of a lower limb;... The Chinese University Of Hong Kong

Centrifugal microfluidic control systems and configuring the same

The disclosure provides a centrifugal microfluidics control system and a method configuring the same. The system may comprise a centrifugal tube; a centrifugal unit for accommodating the centrifugal tube and providing a centrifugal force to the centrifugal tube; a control unit fixed in bottom of the centrifugal tube; and a... The Chinese University Of Hong Kong

System and continuous wave constant amplitude on-resonance and off-resonance spin-lock for magnetic resonance imaging

MRI techniques provide robust imaging in the presence of inhomogeneity in the B1 (RF) and/or B0 magnetic fields. The techniques include using a magnetization prep sequence that includes an adiabatic half passage (AHP) followed by a spin-lock pulse, followed by a reverse AHP, after which a data acquisition sequence can... The Chinese University Of Hong Kong

Method and structural coloration of metallic surfaces

Materials for, and methods of, colorizing a metallic surface with micro-gratings using vibration cutting technologies are provided. Micro-gratings on aluminum, brass, and stainless steel surfaces can be rapidly created to effect, under illumination, at least one color observable in the visible spectrum using elliptical vibration texturing, a vibration-assisted mechanical cutting... The Chinese University Of Hong Kong

Phonetic posteriorgrams for many-to-one voice conversion

A method for converting speech using phonetic posteriorgrams (PPGs). A target speech is obtained and a PPG is generated based on acoustic features of the target speech. Generating the PPG may include using a speaker-independent automatic speech recognition (SI-ASR) system for equalizing different speakers. The PPG includes a set of... The Chinese University Of Hong Kong

Orally-dissolving films for drug delivery through the oral cavity

Orally dissolving films including a pharmaceutically active ingredient having a low bioavailability due to first-pass metabolism and/or low water solubility upon oral administration and a pharmaceutically acceptable excipient, and a medical application thereof.... The Chinese University Of Hong Kong

Phenothiazine-pyridine compounds and uses thereof

The present invention provides a novel phenothiazine-pyridine compound that is an effective photosensitizer useful for photodynamic therapy. Also provided is a method for inhibiting cell proliferation or for treating a disease involving inappropriate cell proliferation.... The Chinese University Of Hong Kong

Detecting hematological disorders using cell-free dna in blood

Techniques are provided for detecting hematological disorders using cell-free DNA in a blood sample, e.g., using plasma or serum. For example, an assay can target one or more differentially-methylated regions specific to a particular hematological cell lineage (e.g., erythroblasts). A methylation level can be quantified from the assay to determine... The Chinese University Of Hong Kong

Methods of fabrication of flexible micro-thermoelectric generators

A cross-plane flexible micro-TEG with hundreds of pairs of thermoelectric pillars formed via electroplating, microfabrication, and substrate transferring processes is provided herein. Typically, fabrication is conducted on a Si substrate, which can be easily realized by commercial production line. The fabricated micro-TEG transferred to the flexible layer from the Si... The Chinese University Of Hong Kong

Apparatus and methods for reducing mutual couplings in an antenna array

A device is presented for improving radio frequency (RF) and microwave array antenna performance. The device sits in the near field, the reactive region, of the antenna array with a pattern of electrically isolated rectangular, cross-shaped, ell, and/or similarly-shaped patches of flat metal or other conductor in a flat plane.... The Chinese University Of Hong Kong

Light modulator using total internal reflection at an interface with a tunable conductive layer

A light modulator (e.g., for terahertz radiation) may be constructed using a prism in which light undergoes total internal reflection (TIR) at one surface. A tunable conductive layer is disposed on the TIR surface. The tunable conductive layer can have a conductivity that is dynamically controllable, e.g., by applying a... The Chinese University Of Hong Kong

Novel polymorph of itraconazole with improved pharmaceutical properties

The present invention provides a new crystalline form of itraconazole as well as the method of making same.... The Chinese University Of Hong Kong

Quantitative magnetic resonance imaging relaxometry with suppression of blood signal

Pulse sequences for an MRI apparatus can provide improved quantitative relaxometry in liver and other tissues. Relaxation parameters such as T1rho or T2 (or both at once) can be measured. The pulse sequence can include a magnetization preparation pulse sequence and an acquisition pulse sequence including a fast spin echo... The Chinese University Of Hong Kong

Evanescent-wave quartz-enhanced photoacoustic sensor with resonator elements

A novel evanescent-wave quartz-enhanced optical microfiber photoacoustic gas sensor is provided for detecting trace amounts of gas. Both fiber-taper based evanescent field and photoacoustic spectroscopy can be used to exploit the merits of both technologies. The use of a fiber half-taper into the tuning fork and microresonator tubes can result... The Chinese University Of Hong Kong

Prodrug of green tea epigallocatechin-3-gallate (pro-egcg) for use in the treatment of endometriosis

Method of treating endometriosis and related indications, comprising the administration of Pro-EGCG, a synthetic and derivative product of epigallocatechin-3-gallate [(−)-EGCG]. Use of Pro-EGCG in the manufacture of a medicament for treating endometriosis and related indications. Pro-EGCG for use in the treatment of endometriosis and related indications.... The Chinese University Of Hong Kong

Biomarker foxf2 for gastric cancer

The present invention provides a method for diagnosing and determining prognosis of gastric cancer in a subject by detecting suppressed expression of the FOXF2 gene, which in some cases is due to elevated methylation level in the genomic sequence of this gene. A kit and device useful for such a... The Chinese University Of Hong Kong

Biomarker rnf6 for colorectal cancer

The present invention provides a method for diagnosing of colorectal cancer in a subject and a method for determining risk of recurrence of colorectal cancer among colorectal cancer patients by detecting overexpression of the RNF6 gene, which in some cases is due to a higher than normal copy number of... The Chinese University Of Hong Kong

Visual disability detection system using virtual reality

Techniques for a visual disability detection system that employs virtual reality to assess visual performance of a patient based on activities of daily living are described. The virtual reality platform can integrate the testing of different components of visual function based on activities of daily living to provide a direct... The Chinese University Of Hong Kong

Method and a system for non-rigid image registration

Disclosed is a method for non-rigid image registration, comprising: dividing a subject image and a target image into a plurality of subject sub-images and a plurality of target sub-images, respectively; registering, in parallel, each of the subject sub-images and the corresponding one of the target sub-images to obtain a transformation... The Chinese University Of Hong Kong

Biomarker scnn1b for gastric cancer

The present invention provides a method for diagnosing and determining prognosis of gastric cancer in a subject by detecting suppressed expression of the SCNN1B gene, which in some cases is due to elevated methylation level in the genomic sequence of this gene. A kit and device useful for such a... The Chinese University Of Hong Kong

Modeling orthopedic casts

A computer-implemented method for modeling an orthopedic cast, including scanning an injured limb to extract raw body data; determining, from the extracted raw body data, a target portion data of the injured limb, the determined data representing a fine cast surface for the orthopedic cast; patterning the fine cast surface... The Chinese University Of Hong Kong

Method and decoding or generating multi-layer color or code, recommending setting parameters in generation of multi-layer or code, and product comprising multi-layer color or code

The present invention discloses a system and a method for decoding QR codes in complex scenes, a system and a method for generating multi-layer color QR codes and applications enabled by the systems and methods. The method for decoding a QR code may include detecting rough locations of the QR... The Chinese University Of Hong Kong

Peptidylyic inhibitor targeting cag-repeat rna toxicity in polyglutamine diseases

The present invention provides for a novel peptide and method for treating polyglutamine (polyQ) diseases. Also disclosed are related compositions and kits for therapeutic use in the treatment of polyQ diseases.... The Chinese University Of Hong Kong

Detecting chromosomal aberrations associated with cancer using genomic sequencing

Methods, systems, and apparatus determine whether a first chromosomal region exhibits a deletion or an amplification associated with cancer in a sample from a subject (e.g., where the sample includes a mixture of cell-free DNA from tumor cells and non-malignant cells. Nucleic acid molecules of the biological sample are sequenced.... The Chinese University Of Hong Kong

Size-based analysis of tumor dna

A classification of a level of cancer in an organism is determined by analyzing a biological sample of the organism. The biological sample comprises clinically-relevant DNA and other DNA. At least some of the DNA is cell-free in the biological sample. An amount of a first set of DNA fragments... The Chinese University Of Hong Kong

Detecting genetic aberrations associated with cancer using genomic sequencing

Methods, systems, and apparatus determine whether a first chromosomal region exhibits a deletion or an amplification associated with cancer in a sample from a subject (e.g., where the sample includes a mixture of cell-free DNA from tumor cells and non-malignant cells. Nucleic acid molecules of the biological sample are sequenced.... The Chinese University Of Hong Kong

Fast and efficient conjugation method based on thiourea-catechol coupling

The present invention provides novel methods and compositions useful for a fast and efficient chemical conjugation method of making hetero-arm polymers based on thiourea-catechol coupling. This novel conjugation method are useful in a wide variety of applications relating to the modification, ligation, and conjugation of large or small molecules to... The Chinese University Of Hong Kong

Nanoparticle contrast agent for early diagnosis of alzheimer's disease by magnetic resonance imaging (mri)

The disclosure herein relates to a novel nanoparticle that can cross the blood-brain barrier and form a bond with amyloid plaques and other related protein aggregates for detection by magnetic resonance imaging (MRI). The compositions, methods of making, and methods of use set forth herein also provide a non-invasive means... The Chinese University Of Hong Kong

Methods and systems for targeted gene manipulation

The present invention provides novel methods and systems, including cell lines, recombinant polynucleotide constructs, compositions, and kits, for targeted yet universal genomic manipulation.... The Chinese University Of Hong Kong

Hardware acceleration for batched sparse codes

Hardware acceleration for batched sparse (BATS) codes is enabled. Hardware implementation of some timing-critical procedures can effectively offload computationally intensive overheads, for example, finite field arithmetic, Gaussian elimination, and belief propagation (BP) calculations, and this can be done without direct mapping of software codes to a hardware implementation. Suitable acceleration... The Chinese University Of Hong Kong

Small molecule inhibitors targeting cag-repeat rna toxicity in polyglutamine diseases

The present invention provides for a novel method for treating polyglutamine (polyQ) diseases. Also disclosed are related compositions and kits for therapeutic use in the treatment of polyQ diseases.... The Chinese University Of Hong Kong

Method for measuring cardiovascular and respiratory parameters based on multi-wavelength photoplethysmography

Accurate and effective methods for measuring cardiovascular and respiratory parameters are provided. The method for deriving a depth-specific photoplethysmography (PPG) signal from multi-wavelength PPG signals includes choosing light wavelength combinations, calibrating a multi-layer light-tissue interaction model referring to a physiological signal, and generating the depth-specific PPG signal from the multi-wavelength... The Chinese University Of Hong Kong

Methods for assessing liver pathologies

The present invention provides a new method for detecting or monitoring a liver disease in a subject that has no indication of any liver pathologies, by measuring the amount of concentration of albumin mRNA in an acellular blood sample from the subject, and then comparing the amount or concentration of... The Chinese University Of Hong Kong

High-energy density and low-cost flow electrochemical devices

The invention provides novel high-energy density and low-cost flow electrochemical devices incorporating solid-flow electrodes, and further provides methods of using such electrochemical devices. Included are anode and cathode current collector foils that can be made to move during discharge or recharge of the device. Solid-flow devices according to the invention... The Chinese University Of Hong Kong

Induction of immunotolerance

The present invention provides for a novel method for inhibiting an undesirable immune response, especially in transplant recipients such as those having received an allogeneic stem cell transplant. Also disclosed are related compositions and kits for inducing immunotolerance.... The Chinese University Of Hong Kong

05/11/17 / #20170132363

Size-based analysis of tumor dna

A classification of a level of cancer in an organism is determined by analyzing a biological sample of the organism. The biological sample comprises clinically-relevant DNA and other DNA. At least some of the DNA is cell-free in the biological sample. An amount of a first set of DNA fragments... The Chinese University Of Hong Kong

04/27/17 / #20170114396

Detecting bacterial taxa for predicting adverse pregnancy outcomes

It provides a method for predicting the risk of an adverse pregnancy or neonatal outcome for a pregnant subject by detecting the elevated level of bacteria from one or more selected bacterial taxa (e.g., genera or species). A kit useful for such a method is also provided. In addition, it... The Chinese University Of Hong Kong

04/20/17 / #20170107265

Met e 1 tropomyosin variants for use in allergen-specific immunotherapy

The present invention provides isolated Met e 1 polypeptides and nucleic acids encoding the isolated polypeptides that can prevent and/or alleviate an allergic response to shellfish tropomyosin. The polypeptides are based on the shrimp tropomyosin Met e 1 protein and have been modified to act as hypoallergens. The Met e... The Chinese University Of Hong Kong

04/13/17 / #20170101685

Diagnostic method

(d) comparing the level of the DNA sequence from the individual to a normal standard, to detect, prognosticate or monitor cancer.... The Chinese University Of Hong Kong

03/30/17 / #20170093666

Loss-resilient protocols for communication networks

BATS protocols may be utilized for high efficiency communication in networks with burst or dependent type losses. Systematic recoding at intermediate network nodes may be utilized to reduce the computational cost during recoding. A block interleaver based BATS protocol may be utilized to handle burst loss, where batches are recoded... The Chinese University Of Hong Kong

03/23/17 / #20170081720

Accurate deduction of fetal dna fraction with shallow-depth sequencing of maternal plasma

Embodiments of the present invention provide methods, systems, and apparatus for deducing the fetal DNA fraction in maternal plasma without using paternal or fetal genotypes. Maternal genotype information may be obtained from a maternal-only DNA sample or may be assumed from shallow-depth sequencing of a biological sample having both maternal... The Chinese University Of Hong Kong

03/23/17 / #20170082845

High-speed binary laser beam shaping and scanning

A device for shaping and scanning an ultrafast laser beam including a laser source configured to output a pulsed laser beam containing different frequency spectrum; a digital micromirror device (DMD) consisting of a plurality of micromirrors, configured to receive the laser beam and shape the received laser beam with a... The Chinese University Of Hong Kong

03/16/17 / #20170073774

Detecting mutations for cancer screening and fetal analysis

Embodiments are related to the accurate detection of somatic mutations in the plasma (or other samples containing cell-free DNA) of cancer patients and for subjects being screened for cancer. The detection of these molecular markers would be useful for the screening, detection, monitoring, management, and prognostication of cancer patients. For... The Chinese University Of Hong Kong

03/16/17 / #20170077665

Diamond maser and microwave amplifier

Masers and microwave amplifiers that can function in the continuous-wave mode at room temperature are provided. The maser system can include a diamond gain medium having nitrogen-vacancy centers, and a resonator can be disposed around the gain medium. The resonator can be disposed in a cavity box, and radiation (e.g.,... The Chinese University Of Hong Kong

03/02/17 / #20170062933

Air-filled patch antenna

Disclosed is an air-filled patch antenna, comprising: a ground plane; a patch arranged to be in parallel to the ground plane; four inherent metal legs extending from the patch perpendicularly, wherein each of distal ends of the four legs is electrically and mechanically connected to the ground plane; and a... The Chinese University Of Hong Kong

03/02/17 / #20170064701

Message coding for ncma-based multiple access networks

Computationally efficient message encoding and decoding schemes for NCMA-based multiple access networks are enabled. Belief propagation decoding of fountain codes designed for NCMA-based multiple access networks may be enhanced using Gaussian elimination. Networks utilizing a network-coded slotted ALOHA protocol can benefit in particular. In such cases, Gaussian elimination may be... The Chinese University Of Hong Kong

02/16/17 / #20170042989

Photosensitized trypanosomatids and vaccine compositions thereof

Disclosed herein are methods and compositions for the delivery of polypeptides, including vaccine candidate polypeptides, into mammalian cells comprising the use of photosensitized trypanosomatid organisms. Also disclosed are methods of treatment of trypanosomatid infections comprising administering phthalocyanine compounds or phthalocyanine-treated trypanosomatid microorganisms as vaccines, as well as and polypeptide delivery... The Chinese University Of Hong Kong

02/16/17 / #20170044606

Single-molecule sequencing of plasma dna

Embodiments may include a method of determining a nucleic acid sequence. The method may include receiving a plurality of DNA fragments. The method may also include concatemerizing a first set of the DNA fragments to obtain a concatemer. The method may include performing single-molecule sequencing of the concatemer to obtain... The Chinese University Of Hong Kong

02/02/17 / #20170029900

Methylation pattern analysis of haplotypes in tissues in a dna mixture

Systems, apparatuses, and method are provided for determining the contributions of different tissues to a biological sample that includes a mixture of cell-free DNA molecules from various tissues types, e.g., as occurs in plasma or serum and other body fluids. Embodiments can analyze the methylation patterns of the DNA mixture... The Chinese University Of Hong Kong

01/26/17 / #20170024513

Analysis of fragmentation patterns of cell-free dna

Factors affecting the fragmentation pattern of cell-free DNA (e.g., plasma DNA) and the applications, including those in molecular diagnostics, of the analysis of cell-free DNA fragmentation patterns are described. Various applications can use a property of a fragmentation pattern to determine a proportional contribution of a particular tissue type, to... The Chinese University Of Hong Kong

01/19/17 / #20170017202

Devices and methods for holographic 3d imaging

A device, system and method for holographic 3D imaging. The device includes a laser light source that delivers a laser beam; an aperture disc including at least two pinholes, the laser beam being filtered by the pinholes so that a reference wave and an object wave are generated; a sample... The Chinese University Of Hong Kong

08/03/17 / #20170220736

Determining progress of chromosomal aberrations over time

Systems, apparatus, and methods are provided for determining aberrations in a biological sample from an organism. Biological samples including cell-free DNA fragments are analyzed to identify imbalances in chromosomal regions, e.g., due to deletions and/or amplifications in a tumor. Multiple loci are used for each chromosomal region. Imbalances can be... The Chinese University Of Hong Kong








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