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The Curators Of The University Of Missouri
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The Curators Of The University Of Missouri patents


Recent patent applications related to The Curators Of The University Of Missouri. The Curators Of The University Of Missouri is listed as an Agent/Assignee. Note: The Curators Of The University Of Missouri may have other listings under different names/spellings. We're not affiliated with The Curators Of The University Of Missouri, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "T" | The Curators Of The University Of Missouri-related inventors


Grain refinement in iron-based materials

A process for manufacturing an iron-based alloy comprising forming targeted fine oxide and/or carbide dispersoids in a melt, and sequentially precipitating transition-metal nitrides on the dispersoids for heterogeneous nucleation of equiaxed grains. An iron-based cast alloy having a highly equiaxed fine grain structure.... The Curators Of The University Of Missouri

Fiber-optic micro-probes for measuring acidity level, temperature, and antigens

A pH micro-probe, a temperature micro-probe, and an immuno-based micro-probe each include a shaft for transmuting an input light signal and a tip for inserting into a cell or other substance for measuring pH, temperature, and/or antigens. The pH micro-probe and the temperature micro-probe each include a luminescent material positioned... The Curators Of The University Of Missouri

Spectral analysis of surface waves to detect subsurface voids

Systems and methods for detecting a subsurface cavity. A source applies a force to ground under inspection and a plurality of sensors coupled to the ground detect resulting surface waves. A processor is configured to extract phase and frequency components of the acquired seismic data, identify a phase shift in... The Curators Of The University Of Missouri

Multimodal silica-based nanoparticles

The present invention provides a fluorescent silica-based nanoparticle that allows for precise detection, characterization, monitoring and treatment of a disease such as cancer. The nanoparticle has a range of diameters including between about 0.1 nm and about 100 nm, between about 0.5 nm and about 50 nm, between about 1... The Curators Of The University Of Missouri

Epoxy phosphonate ester as a coupling agent for transition metal and metal oxide surfaces

A method for surface modification of a substrate comprising surface oxide and/or hydroxy groups, with a compound comprising an ester group and an epoxy ring, wherein the epoxy group remains intact after the reacting. A method for surface modification of a substrate comprising surface oxide and/or hydroxy groups, with a... The Curators Of The University Of Missouri

Artificial oocyte activation

The present invention provides novel methods for improving the efficiency of artificial activation of unfertilized mammalian oocytes by reducing the intracellular concentration of Zn2+ in the oocyte. The methods of the invention may additionally comprise a preceding step of increasing the intracellular concentration of Ca2+ in the oocyte prior to... The Curators Of The University Of Missouri

Photoacoustic flow cell for identification of rare analytes in suspension

A photoacoustic flow cell, the components of which may be made well in advance of conducting photoacoustic analysis, comprising (a) a chamber structure that defines a chamber, a chamber inlet, and a chamber outlet, and (b) a glass test structure, at least a portion of which is supported by the... The Curators Of The University Of Missouri

Compositions and methods for synthetic amphiphile-induced changes in plant root morphology

The disclosure provides a method for increasing the lateral root development of a plant by exposing said plant to a composition containing a synthetic amphiphile. By increasing the number of lateral roots, the surface area of the root structure is increased, making the plants better able to survive such stresses... The Curators Of The University Of Missouri

Fabrication of multilayer nanograting structures

Provided are nanograting structures and methods of fabrication thereof that allow for stable, robust gratings and nanostructure embedded gratings that enhance electromagnetic field, fluorescence, and photothermal coupling through surface plasmon or, photonic resonance. The gratings produced exhibit long term stability of the grating structure and improved shelf life without degradation... The Curators Of The University Of Missouri

Drosophila model of human cervical cancer

Disclosed is a transgenic Drosophila model of human papillomavirus-mediated cancer. Also disclosed is a method for screening a candidate therapeutic for Human papillomavirus-induced cell transformation and a method for screening a candidate therapeutic for Human papillomavirus-induced cell transformation.... The Curators Of The University Of Missouri

Low temperature nanowire growth on arbitrary substrates

The present invention provides a method to manufacture nanowires. In various embodiments, a method is provided for producing an oxidized metal layer as a heterogeneous seed layer on arbitrary substrate for controlled nanowire growth is disclosed which comprises depositing a metal layer on a substrate, oxidizing the metal layer in... The Curators Of The University Of Missouri

Porcine reproductive and respiratory syndrome virus resistant animals

The present invention generally relates to genetically modified swine wherein at least one allele of a SIGLEC1 gene has been inactivated and/or at least one allele of a CD163 gene has been inactivated. Genetically modified swine having both alleles of the SIGLEC1 gene and/or both alleles CD163 gene inactivated are... The Curators Of The University Of Missouri

Multifunctional cerium-based nanomaterials and methods for producing the same

Embodiments relate to a cerium-containing nano-coating composition, the composition including an amorphous matrix including one or more of cerium oxide, cerium hydroxide, and cerium phosphate; and crystalline regions including one or more of crystalline cerium oxide, crystalline cerium hydroxide, and crystalline cerium phosphate. The diameter of each crystalline region is... The Curators Of The University Of Missouri

Variable product agrochemicals application management

... The Curators Of The University Of Missouri

Distributed energy storage system

An energy storage system reaction cell configured for distribution throughout a transport system. The length of the reaction cell is substantially greater than its width and is looped throughout the transport system in a serpentine configuration. A membrane within the reaction cell has a length substantially equal to the length... The Curators Of The University Of Missouri

Metallic and protein/polymer nanoparticle constructs, multi-drug vehicle and fabrication methods

A multidimensional nanoconstruct includes a three-dimensional thiolated protein, gelatin or polymer nanoparticle and exposed metallic nanoparticles bonded to outer surfaces of the particle. In a method of formation, number of metallic nanoparticles that attach to the carrier nanoparticle is controlled via microfluidics or via controlling the reactivity of the metallic... The Curators Of The University Of Missouri

Encoded nanopore sensor for multiplex nucleic acids detection

The present invention provides a new and improved multiplexed oligonucleotide detection method based on the nanopore technology with one or more probes containing a sequence with complementarity to the target oligonucleotide, a terminal extension at the probe's 3′ terminus, 5′ terminus, or both termini and a label attached to the... The Curators Of The University Of Missouri

Inorganic biodegradable substrates for devices and systems

Disclosed are biodegradable glass substrates that are useful as functional elements of solid-state devices. In particular, biodegradable glass substrates having a rapidly degradable glass and a slowly degradable glass provide a structural platform that completely dissolves following a desired operational lifetime of devices such as implanted electronic devices, implanted sensor... The Curators Of The University Of Missouri

Enhancement of antibiotic efficacy

Methods and compositions are provided for increasing or enhancing the efficacy of antibiotics, such as by increasing antimicrobial activity, against a variety of microbes by co-administration with synthetic amphiphiles, including lariat ethers and hydraphiles. Methods and compositions for overcoming antibiotic resistance are also provided.... The Curators Of The University Of Missouri

Microdystrophin peptides and methods for treating muscular dystrophy using the same

According to the embodiments described herein, a series of biological materials for treatment/therapy of DMD and/or BMD through the recovery of sarcolemmal nNOS is provided. The biological material comprises the complete dystrophin repeats R16 and R17 or certain domains, sections, or fragments of the dystrophin repeats R16 and R17. In... The Curators Of The University Of Missouri

Method for treating lymphedema

The disclosure relates to the field of lymphedema therapy, more specifically, to a new pharmacological strategy to rescue the failed lymph pump system that can supplement, enhance or replace current therapies.... The Curators Of The University Of Missouri

Addressable electrode arrays in multiple fluidic compartments and uses thereof

Methods and apparati for performing measurements of electrical signals in a multi-compartmented fluidic array format where the signal to noise ratio is improved are disclosed.... The Curators Of The University Of Missouri

Apparatus, conversion of scalar particle flow to an electrical output

A scalar particle conversion apparatus, system and method are disclosed. The apparatus includes an anode and a crystalline cathode disposed within an electrolytic fluid or gas. A voltage source is configured to generate a current between the anode and the cathode and one or more components within the electrolytic fluid... The Curators Of The University Of Missouri

Solid-state nuclear energy conversion system

A solid-state nuclear energy conversion system includes a crystalline insulator bombarded with radiation to create electron-hole pairs. A voltage source provides a potential bias across the crystalline insulator, causing electrons and holes to collect at opposing ends. A diode is incorporated in a circuit including the crystalline insulator, voltage source,... The Curators Of The University Of Missouri

Method and fabricating ceramic and metal components via additive manufacturing with uniform layered radiation drying

A freeform extrusion fabrication process for producing three-dimensional ceramic, metal and functionally gradient composite objects, including the steps of filling a plurality of paste sources with a respective plurality of aqueous paste compositions, operationally connecting respective syringes containing respective aqueous paste compositions to a mixing chamber, moving a first aqueous... The Curators Of The University Of Missouri

Visual storytelling authentication

Method, system and media for authenticating a subject as a user. Embodiments generate visual stories specific to the user and for which the subject must select the corresponding images from among a plurality of decoy images. Gaze tracking can be used to determine which images the user has selected without... The Curators Of The University Of Missouri

System, apparatus, and grafting tissue

Systems, apparatus, and methods may be adapted for grafting tissue at a tissue site that may include an elongate housing and a plurality of elongate cutting members. The plurality of elongate cutting members may define a cutting surface at a distal end of the elongate housing. The cutting surface may... The Curators Of The University Of Missouri

Medium supplement to increase the efficiency of oocyte maturation and embryo culture in vitro

The present invention provides a novel oocyte maturation medium or/and embryo culture medium with a chemically defined supplement to produce matured oocytes at high efficiency. The inventive medium or supplement comprises three growth factors, namely, fibroblast growth factor 2 (FGF2), leukemia inhibitory factor (LIF), and insulin-like growth factor 1 (IGF-1)... The Curators Of The University Of Missouri

Method for preparing loaded nanoparticles

Novel pentablock polymers having a PCL-PLA-PEG-PLA-PCL or PCL-PGA-PEG-PGA-PCL configuration, wherein PEG is polyethylene glycol, PCL is poly(ε-caprolactone), PGA is poly(glycolic acid), and PLA is poly(lactic acid), and methods of making nanoparticles from the pentablock polymers, are disclosed. The invention is also directed to a method for preparing nanoparticle compositions comprised... The Curators Of The University Of Missouri

Cancer immune-based therapy

The present disclosure provides a novel therapeutic vaccine approach that triggers a therapeutic antitumor response. The inventive approach is to selectively eliminate the carbohydrate sequences from tumor cells without affecting the tumor associated protein epitopes.... The Curators Of The University Of Missouri

Method to produce inorganic nanomaterials and compositions thereof

A solid state method of producing inorganic nanoparticles using glass is disclosed. The nanoparticles may not be formed until the glass is reacted with or degraded by contact with a fluid in vivo or in vitro.... The Curators Of The University Of Missouri

Prostate-specific membrane antigen (psma) targeting peptides

Described herein is the discovery of novel PSMA-specific peptides, which were identified through a novel combinatorial biopanning method. One of the novel PSMA-specific peptides discovered, GTIQPYPFSWGY (or GTI) (SEQ ID NO: 2), exhibits high binding affinity and selectivity to PSMA and PSMA-positive prostate cancer cells. It was found that GTI... The Curators Of The University Of Missouri

Thread shaped contact electrification fiber

An electrostatic power generation fiber comprising a thread-shaped core that comprises a conductive component; a charge building-inducting-tunneling layer on the core that comprises a contact electrification material. An embodiment of the present invention is directed to an electrostatic power generation fiber comprising: (a) a thread-shaped core that comprises a conductive... The Curators Of The University Of Missouri

Dental etchant compositions comprising one or more dentin collagen cross-linking agents, methods of producing the same, and methods of use

Dental etchant compositions, processes for making the same, and methods for using the dental etchant compositions are disclosed. The dental etchant compositions include at least one acid and one or more dentin collagen cross-linking agents. The methods for using the dental etchant compositions may include contacting a mammal's tooth with... The Curators Of The University Of Missouri

Eccentric weightlifting machine and associated use

An eccentric weightlifting machine that includes a first pole connected to a first weight and to a device acted on by a user, a second pole connected to a second weight and to a motor, wherein the motor lifts the second pole in response to movement of the first pole... The Curators Of The University Of Missouri

07/06/17 / #20170191471

Electrical/chemical thruster using the same monopropellant and method

A thruster operable in a chemical mode or in an electrospray mode using the same liquid monopropellant for operation in both modes is described having a multiplicity of a microthrusters made of a catalytic material having a bore therethrough, where, when operated in the chemical mode, the microthrusters are heated... The Curators Of The University Of Missouri

06/22/17 / #20170172585

System, apparatus, and creation and implantation of tissue grafts

Systems, apparatus, and methods for forming a non-circular tissue graft from donor tissue, and a corresponding recipient site in patient's tissue, are disclosed. In one embodiment, a cutting guide is disclosed for use in forming the recipient site. The cutting guide comprises a deformable body including a non-circular window, through... The Curators Of The University Of Missouri

06/15/17 / #20170168045

Au multicomponent nanomaterials and synthesis methods

A multicomponent nanomaterial AuNP(DTDTPA)(Ga), where DTDTPA is an amino-carboxylate ligand (diethylene triamine pentaacetic acid, DTPA) linked to the surface of the Au nanoparticle (NP) via dithiol (DT) linkage. Another embodiment is a multicomponent nanomaterial AuNP(DTDTPA)(Ga) with a biomolecule attached. In preferred embodiments, the Ga is Ga-67 or Ga-68. Preferred synthesis... The Curators Of The University Of Missouri

06/01/17 / #20170152474

Self-assembling multicellular bodies and methods of producing a three-dimensional biological structure using the same

Structures and methods for tissue engineering include a multicellular body including a plurality of living cells. A plurality of multicellular bodies can be arranged in a pattern and allowed to fuse to form an engineered tissue. The arrangement can include filler bodies including a biocompatible material that resists migration and... The Curators Of The University Of Missouri

05/25/17 / #20170143240

Activity analysis, fall detection and risk assessment systems and methods

A method for determining the risk of a person falling is provided. The method includes acquiring depth image data that comprises a plurality of frames that depict a person walking through a home, and extracting a foreground object from the depth image data. The method additionally includes generating a three-dimensional... The Curators Of The University Of Missouri

05/25/17 / #20170145386

Self-assembling cell aggregates and methods of making engineered tissue using the same

A composition comprising a plurality of cell aggregates for use in the production of engineered organotypic tissue by organ printing. A method of making a plurality of cell aggregates comprises centrifuging a cell suspension to form a pellet, extruding the pellet through an orifice, and cutting the extruded pellet into... The Curators Of The University Of Missouri

05/18/17 / #20170137376

Flexible to rigid nanoporous polyurethane-acrylate (puac) type materials for structural and thermal insulation applications

Novel urethane-acrylate (UAC) Star monomers and polyurethane-acrylate (PUAC) aerogel polymers derived therefrom are described herein, along with other novel, related monomers and polymers. Also described herein are processes for preparing the UAC Star monomers, the PUAC aerogel polymers, and the other related monomers and polymers. The PUAC and related polymers... The Curators Of The University Of Missouri

05/04/17 / #20170121354

Epoxy phosphonate ester as a coupling agent for transition metal and metal oxide surfaces

A method for surface modification of a substrate comprising surface oxide and/or hydroxy groups, with a compound comprising an ester group and an epoxy ring, wherein the epoxy group remains intact after the reacting. A method for surface modification of a substrate comprising surface oxide and/or hydroxy groups, with a... The Curators Of The University Of Missouri

03/30/17 / #20170093267

Device for generating electrical power from low frequency oscillations

An energy harvesting device for generating electrical power from low-frequency oscillations includes a high-frequency cantilever, a plurality of low-frequency cantilevers each configured to contact the high-frequency cantilever in response to environmental vibrations having a frequency within a near-resonance frequency range associated with said low-frequency cantilever, an a generator that produces... The Curators Of The University Of Missouri

03/23/17 / #20170082645

Near-infrared fluorescent sensors for biological amines

wherein R4 is selected from the group consisting of (CH3)2Si, O, N, S, and CH2.... The Curators Of The University Of Missouri

03/09/17 / #20170064920

Waste heat recovery a livestock barn

A system and method for thermally exchanging heat between waste air being expelled from a poultry barn and fresh outside/outdoor ambient air being introduced into the poultry barn.... The Curators Of The University Of Missouri

03/09/17 / #20170066785

Synthesis of amine boranes and polyhedral boranes

The present invention relates in general to a method for the synthesis and purification of 1) the polyhedral borane decahydrodecaborate and dodecahydrododecaborate anions and their salts and 2) amines and amine boranes. The organoammonium halide is combined with alkali metal tetrahydroborate to form organoammonium tetrahydroborate, which upon pyrolysis provides organoammonium... The Curators Of The University Of Missouri

03/09/17 / #20170066790

Fluorescent labeled inhibitors

Provided herein are a series of fluorescently labeled phosphonate and phosphate compounds such as can be used for affinity probes to detect certain enzymes including lipases. Also provided are methods of making and using such compounds.... The Curators Of The University Of Missouri

03/02/17 / #20170056023

Device and allografting

In one embodiment, a cutting guide is disclosed for use in a surgical procedure to removed damaged tissue from a patient and form a recipient site configured and dimensioned to receive a donor graft. The cutting guide includes a first arm that abuts a section of the damaged tissue to... The Curators Of The University Of Missouri

03/02/17 / #20170058381

Method for separation of chemically pure os from metal mixtures

A method for separating an amount of osmium from a mixture containing the osmium and at least one other additional metal is provided. In particular, method for forming and trapping OsO4 to separate the osmium from a mixture containing the osmium and at least one other additional metal is provided.... The Curators Of The University Of Missouri

03/02/17 / #20170062798

Dry powder based electrode additive manufacturing

A dry electrode manufacturing process employed for low cost battery through a dry mixing and formation process. A thermal activation renders the dry fabricated electrode comparable to conventional slurry casted electrodes. The dry electrode mixture results from a combination of a plurality of types of constituent particles, including at least... The Curators Of The University Of Missouri

03/02/17 / #20170064803

Systems and methods to generate a self-confined high density air plasma

This disclosure relates to methods and devices for generating electron dense air plasmas at atmospheric pressures. In particular, this disclosure relate to self-contained toroidal air plasmas. Methods and apparatuses have been developed for generating atmospheric toroidal air plasmas. The air plasmas are self-confining, can be projected, and do not require... The Curators Of The University Of Missouri

02/23/17 / #20170054364

High voltage gain dc/dc power electronic converters

A DC/DC power converter provides high voltage gain using integrated boost and voltage multiplier (VM) stages. The boost cell operates according to a switching sequence to alternately energize and discharge a primary winding. A VM cell electrically coupled to the primary winding of the boost cell charges a multiplier capacitor... The Curators Of The University Of Missouri

02/09/17 / #20170035035

Pathogen-resistant animals having modified cd163 genes

Non-human animals and offspring thereof comprising at least one modified chromosomal sequence in a gene encoding a CD163 protein are provided. Animal cells that contain such modified chromosomal sequences are also provided. The animals and cells have increased resistance to pathogens, including porcine reproductive and respiratory syndrome virus (PRRSV). The... The Curators Of The University Of Missouri

02/09/17 / #20170038362

Combination of single-cell electroporation and electrical recording using the same electrode

Methods for stimulating exocytosis from a cell are provided where the same electrochemical microelectrode is used to electroporate an adjacent cell and then measure quantal exocytosis from the adjacent cell. Also provided are methods for stimulating and measuring exocytosis from a select cell population arrayed on a chip comprising addressable... The Curators Of The University Of Missouri

02/09/17 / #20170039449

Method of predicting crop yield loss due to n-deficiency

A method for determining the yield loss of a crop using remote sensor data is described. The yield loss is determined using the reflectivity of light by the crop canopy measured from remote sensor data such as an aerial photograph. Pixel color values from the aerial photograph, expressed relative to... The Curators Of The University Of Missouri

02/02/17 / #20170030925

Biomarkers of osteoarthritis

Biomarkers, biomarker panels and methods for diagnosing osteoarthritis (OA) and determining treatment are disclosed, using measurement of the expression level of certain polypeptides in a test sample from a subject, including MCP1, IL8, KC, MMP2, MMP3, Apolipoprotein A1, and Apolipoprotein E. Related methods for monitoring OA treatment efficacy, diagnostic reagents,... The Curators Of The University Of Missouri

02/02/17 / #20170030985

Device for subdividing magnetic field and simultaneous detection of magnetic resonance signals from multiple sample compartments

Devices and methods are provided for simultaneously interrogating multiple samples using NMR spectroscopy. A first magnetic field is induced. A flow of electricity is induced through a conductive material. The flow of electricity has a direction that is perpendicular to the first magnetic field, and the flow of electricity induces... The Curators Of The University Of Missouri

02/02/17 / #20170031143

Optical polarization tractography systems, methods and devices

High-resolution 3D optical polarization tractography (OPT) images of the internal fiber structure of a target tissue. Manipulation of dual-angle imaging data of the fiber orientation inside a target tissue leads to the determination of 3D imaging properties of the target tissue, allowing transmission of the 3D image properties of the... The Curators Of The University Of Missouri

02/02/17 / #20170032862

Mass production loading radioisotopes into radiovoltaics

A method of producing an integrated circuit-type active radioisotope battery, the method comprising exposing at least a portion of an electronically functional, unactivated integrated circuit-type battery to radiation to convert transmutable material in the unactivated battery to a radioisotope thereby producing an active cell and thus the integrated circuit-type active... The Curators Of The University Of Missouri

01/19/17 / #20170014542

Wound care compositions

Glass-based particles of a biocompatible material which comprises 40 to about 80 wt % borate (B2O3) intermixed into a carrier which is an ointment, cream, or surgical glue.... The Curators Of The University Of Missouri

01/12/17 / #20170007700

Compositions and methods for boron neutron capture therapy

Provided herein are compositions and methods for boron neutron capture therapy. In particular, the disclosure relates to therapy using liposomal Na3[1-(2′-B10H9)-2-NH3B10H8] and K[nido-7-CH3(CH2)15-7,8-C2B9H11] sources. A composition for boron neutron capture therapy, comprising a liposome having an aqueous core and an encapsulating bilayer, wherein the aqueous core comprises Na3[1-(2′-B10H9)-2-NH3B10H8] (TAC) and... The Curators Of The University Of Missouri

01/12/17 / #20170009366

Egcg stabilized pd nanoparticles, making, and electrochemical cell

The invention provides stabilized, biocompatible palladium nanoparticles that are stabilized with material from epigallocatechin Gallate (EGCG). The invention also provides electrochemical cells that include EGCG stabilized nanoparticles, and an electrolyte. In preferred embodiments, EGCG palladium nanoparticles are in D2O or H2O, and preferred electrolytes are adjusted for conductivity with LiOD... The Curators Of The University Of Missouri

01/05/17 / #20170000729

Methods and compositions for treatment of neurodegenerative diseases

The present invention provides methods and compositions for treating a neurodegeneration disease or retinal degenerative disease in a mammal comprising the use of mesenchymal stem cells expressing a therapeutic compound. The invention also provides cells and constructs for use in such methods. Also provided are kits for treatment of a... The Curators Of The University Of Missouri

01/05/17 / #20170000748

Method for enhancing amidohydrolase activity of fatty acid amide hydrolase

A method for enhancing amidohydrolase activity of Fatty Acid Amide Hydrolase (FAAH) is disclosed. The method comprising administering a phenoxyacyl-ethanolamide that causes the enhanced activity. The enhanced activity can have numerous effects on biological organisms including, for example, enhancing the growth of certain seedlings.... The Curators Of The University Of Missouri

Patent Packs
01/05/17 / #20170002403

Nanopore-facilitated single molecule detection of nucleic acids

The present invention provides a new and improved oligonucleotide detection method based on the nanopore technology with a probe containing a complementary sequence to the target oligonucleotide and a terminal extension at the probe's 3′ terminus, 5′ terminus, or both termini. The improved nanopore sensor with the probe enables sensitive,... The Curators Of The University Of Missouri








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