The Curators Of The University Of Missouri patents

Grain refinement in iron-based materials

A process for manufacturing an iron-based alloy comprising forming targeted fine oxide and/or carbide dispersoids in a melt, and sequentially precipitating transition-metal nitrides on the dispersoids for heterogeneous nucleation of equiaxed grains. An iron-based cast alloy having a highly equiaxed fine grain structure.... The Curators Of The University Of Missouri

Fiber-optic micro-probes for measuring acidity level, temperature, and antigens

A pH micro-probe, a temperature micro-probe, and an immuno-based micro-probe each include a shaft for transmuting an input light signal and a tip for inserting into a cell or other substance for measuring pH, temperature, and/or antigens. The pH micro-probe and the temperature micro-probe each include a luminescent material positioned... The Curators Of The University Of Missouri

Spectral analysis of surface waves to detect subsurface voids

Systems and methods for detecting a subsurface cavity. A source applies a force to ground under inspection and a plurality of sensors coupled to the ground detect resulting surface waves. A processor is configured to extract phase and frequency components of the acquired seismic data, identify a phase shift in... The Curators Of The University Of Missouri

Multimodal silica-based nanoparticles

The present invention provides a fluorescent silica-based nanoparticle that allows for precise detection, characterization, monitoring and treatment of a disease such as cancer. The nanoparticle has a range of diameters including between about 0.1 nm and about 100 nm, between about 0.5 nm and about 50 nm, between about 1... The Curators Of The University Of Missouri

Epoxy phosphonate ester as a coupling agent for transition metal and metal oxide surfaces

A method for surface modification of a substrate comprising surface oxide and/or hydroxy groups, with a compound comprising an ester group and an epoxy ring, wherein the epoxy group remains intact after the reacting. A method for surface modification of a substrate comprising surface oxide and/or hydroxy groups, with a... The Curators Of The University Of Missouri

Artificial oocyte activation

The present invention provides novel methods for improving the efficiency of artificial activation of unfertilized mammalian oocytes by reducing the intracellular concentration of Zn2+ in the oocyte. The methods of the invention may additionally comprise a preceding step of increasing the intracellular concentration of Ca2+ in the oocyte prior to... The Curators Of The University Of Missouri

Photoacoustic flow cell for identification of rare analytes in suspension

A photoacoustic flow cell, the components of which may be made well in advance of conducting photoacoustic analysis, comprising (a) a chamber structure that defines a chamber, a chamber inlet, and a chamber outlet, and (b) a glass test structure, at least a portion of which is supported by the... The Curators Of The University Of Missouri

Compositions and methods for synthetic amphiphile-induced changes in plant root morphology

The disclosure provides a method for increasing the lateral root development of a plant by exposing said plant to a composition containing a synthetic amphiphile. By increasing the number of lateral roots, the surface area of the root structure is increased, making the plants better able to survive such stresses... The Curators Of The University Of Missouri

Fabrication of multilayer nanograting structures

Provided are nanograting structures and methods of fabrication thereof that allow for stable, robust gratings and nanostructure embedded gratings that enhance electromagnetic field, fluorescence, and photothermal coupling through surface plasmon or, photonic resonance. The gratings produced exhibit long term stability of the grating structure and improved shelf life without degradation... The Curators Of The University Of Missouri

Drosophila model of human cervical cancer

Disclosed is a transgenic Drosophila model of human papillomavirus-mediated cancer. Also disclosed is a method for screening a candidate therapeutic for Human papillomavirus-induced cell transformation and a method for screening a candidate therapeutic for Human papillomavirus-induced cell transformation.... The Curators Of The University Of Missouri

Low temperature nanowire growth on arbitrary substrates

The present invention provides a method to manufacture nanowires. In various embodiments, a method is provided for producing an oxidized metal layer as a heterogeneous seed layer on arbitrary substrate for controlled nanowire growth is disclosed which comprises depositing a metal layer on a substrate, oxidizing the metal layer in... The Curators Of The University Of Missouri

Porcine reproductive and respiratory syndrome virus resistant animals

The present invention generally relates to genetically modified swine wherein at least one allele of a SIGLEC1 gene has been inactivated and/or at least one allele of a CD163 gene has been inactivated. Genetically modified swine having both alleles of the SIGLEC1 gene and/or both alleles CD163 gene inactivated are... The Curators Of The University Of Missouri

Multifunctional cerium-based nanomaterials and methods for producing the same

Embodiments relate to a cerium-containing nano-coating composition, the composition including an amorphous matrix including one or more of cerium oxide, cerium hydroxide, and cerium phosphate; and crystalline regions including one or more of crystalline cerium oxide, crystalline cerium hydroxide, and crystalline cerium phosphate. The diameter of each crystalline region is... The Curators Of The University Of Missouri

Variable product agrochemicals application management

... The Curators Of The University Of Missouri

Distributed energy storage system

An energy storage system reaction cell configured for distribution throughout a transport system. The length of the reaction cell is substantially greater than its width and is looped throughout the transport system in a serpentine configuration. A membrane within the reaction cell has a length substantially equal to the length... The Curators Of The University Of Missouri

Metallic and protein/polymer nanoparticle constructs, multi-drug vehicle and fabrication methods

A multidimensional nanoconstruct includes a three-dimensional thiolated protein, gelatin or polymer nanoparticle and exposed metallic nanoparticles bonded to outer surfaces of the particle. In a method of formation, number of metallic nanoparticles that attach to the carrier nanoparticle is controlled via microfluidics or via controlling the reactivity of the metallic... The Curators Of The University Of Missouri

Encoded nanopore sensor for multiplex nucleic acids detection

The present invention provides a new and improved multiplexed oligonucleotide detection method based on the nanopore technology with one or more probes containing a sequence with complementarity to the target oligonucleotide, a terminal extension at the probe's 3′ terminus, 5′ terminus, or both termini and a label attached to the... The Curators Of The University Of Missouri

Inorganic biodegradable substrates for devices and systems

Disclosed are biodegradable glass substrates that are useful as functional elements of solid-state devices. In particular, biodegradable glass substrates having a rapidly degradable glass and a slowly degradable glass provide a structural platform that completely dissolves following a desired operational lifetime of devices such as implanted electronic devices, implanted sensor... The Curators Of The University Of Missouri

Enhancement of antibiotic efficacy

Methods and compositions are provided for increasing or enhancing the efficacy of antibiotics, such as by increasing antimicrobial activity, against a variety of microbes by co-administration with synthetic amphiphiles, including lariat ethers and hydraphiles. Methods and compositions for overcoming antibiotic resistance are also provided.... The Curators Of The University Of Missouri

Microdystrophin peptides and methods for treating muscular dystrophy using the same

According to the embodiments described herein, a series of biological materials for treatment/therapy of DMD and/or BMD through the recovery of sarcolemmal nNOS is provided. The biological material comprises the complete dystrophin repeats R16 and R17 or certain domains, sections, or fragments of the dystrophin repeats R16 and R17. In... The Curators Of The University Of Missouri

Method for treating lymphedema

The disclosure relates to the field of lymphedema therapy, more specifically, to a new pharmacological strategy to rescue the failed lymph pump system that can supplement, enhance or replace current therapies.... The Curators Of The University Of Missouri

Addressable electrode arrays in multiple fluidic compartments and uses thereof

Methods and apparati for performing measurements of electrical signals in a multi-compartmented fluidic array format where the signal to noise ratio is improved are disclosed.... The Curators Of The University Of Missouri

Apparatus, conversion of scalar particle flow to an electrical output

A scalar particle conversion apparatus, system and method are disclosed. The apparatus includes an anode and a crystalline cathode disposed within an electrolytic fluid or gas. A voltage source is configured to generate a current between the anode and the cathode and one or more components within the electrolytic fluid... The Curators Of The University Of Missouri

Solid-state nuclear energy conversion system

A solid-state nuclear energy conversion system includes a crystalline insulator bombarded with radiation to create electron-hole pairs. A voltage source provides a potential bias across the crystalline insulator, causing electrons and holes to collect at opposing ends. A diode is incorporated in a circuit including the crystalline insulator, voltage source,... The Curators Of The University Of Missouri

Method and fabricating ceramic and metal components via additive manufacturing with uniform layered radiation drying

A freeform extrusion fabrication process for producing three-dimensional ceramic, metal and functionally gradient composite objects, including the steps of filling a plurality of paste sources with a respective plurality of aqueous paste compositions, operationally connecting respective syringes containing respective aqueous paste compositions to a mixing chamber, moving a first aqueous... The Curators Of The University Of Missouri

Visual storytelling authentication

Method, system and media for authenticating a subject as a user. Embodiments generate visual stories specific to the user and for which the subject must select the corresponding images from among a plurality of decoy images. Gaze tracking can be used to determine which images the user has selected without... The Curators Of The University Of Missouri

System, apparatus, and grafting tissue

Systems, apparatus, and methods may be adapted for grafting tissue at a tissue site that may include an elongate housing and a plurality of elongate cutting members. The plurality of elongate cutting members may define a cutting surface at a distal end of the elongate housing. The cutting surface may... The Curators Of The University Of Missouri

Medium supplement to increase the efficiency of oocyte maturation and embryo culture in vitro

The present invention provides a novel oocyte maturation medium or/and embryo culture medium with a chemically defined supplement to produce matured oocytes at high efficiency. The inventive medium or supplement comprises three growth factors, namely, fibroblast growth factor 2 (FGF2), leukemia inhibitory factor (LIF), and insulin-like growth factor 1 (IGF-1)... The Curators Of The University Of Missouri

Method for preparing loaded nanoparticles

Novel pentablock polymers having a PCL-PLA-PEG-PLA-PCL or PCL-PGA-PEG-PGA-PCL configuration, wherein PEG is polyethylene glycol, PCL is poly(ε-caprolactone), PGA is poly(glycolic acid), and PLA is poly(lactic acid), and methods of making nanoparticles from the pentablock polymers, are disclosed. The invention is also directed to a method for preparing nanoparticle compositions comprised... The Curators Of The University Of Missouri

Cancer immune-based therapy

The present disclosure provides a novel therapeutic vaccine approach that triggers a therapeutic antitumor response. The inventive approach is to selectively eliminate the carbohydrate sequences from tumor cells without affecting the tumor associated protein epitopes.... The Curators Of The University Of Missouri

Method to produce inorganic nanomaterials and compositions thereof

A solid state method of producing inorganic nanoparticles using glass is disclosed. The nanoparticles may not be formed until the glass is reacted with or degraded by contact with a fluid in vivo or in vitro.... The Curators Of The University Of Missouri

Prostate-specific membrane antigen (psma) targeting peptides

Described herein is the discovery of novel PSMA-specific peptides, which were identified through a novel combinatorial biopanning method. One of the novel PSMA-specific peptides discovered, GTIQPYPFSWGY (or GTI) (SEQ ID NO: 2), exhibits high binding affinity and selectivity to PSMA and PSMA-positive prostate cancer cells. It was found that GTI... The Curators Of The University Of Missouri

Thread shaped contact electrification fiber

An electrostatic power generation fiber comprising a thread-shaped core that comprises a conductive component; a charge building-inducting-tunneling layer on the core that comprises a contact electrification material. An embodiment of the present invention is directed to an electrostatic power generation fiber comprising: (a) a thread-shaped core that comprises a conductive... The Curators Of The University Of Missouri

Dental etchant compositions comprising one or more dentin collagen cross-linking agents, methods of producing the same, and methods of use

Dental etchant compositions, processes for making the same, and methods for using the dental etchant compositions are disclosed. The dental etchant compositions include at least one acid and one or more dentin collagen cross-linking agents. The methods for using the dental etchant compositions may include contacting a mammal's tooth with... The Curators Of The University Of Missouri

Eccentric weightlifting machine and associated use

An eccentric weightlifting machine that includes a first pole connected to a first weight and to a device acted on by a user, a second pole connected to a second weight and to a motor, wherein the motor lifts the second pole in response to movement of the first pole... The Curators Of The University Of Missouri