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The General Hospital Corporation D b a Massachusetts General Hospital
The General Hospital Corporation D b a Massachusets General Hospital
The General Hospital Corporation D b a Massachusettes General Hospital
The General Hospital Corporation D b a Massachuset General Hospital
The General Hospital Corporation D b a Massachuset Ts General Hospital
The General Hospital Corporation D b a Massachuset
The General Hospital Corporation D b a Massachusettls General Hospital
The General Hospital Corporation D b a Massachusetts Gerneral Hospital

The General Hospital Corporation D b a Massachuset patents


Recent patent applications related to The General Hospital Corporation D b a Massachuset. The General Hospital Corporation D b a Massachuset is listed as an Agent/Assignee. Note: The General Hospital Corporation D b a Massachuset may have other listings under different names/spellings. We're not affiliated with The General Hospital Corporation D b a Massachuset, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "T" | The General Hospital Corporation D b a Massachuset-related inventors


Inhibitors of histone deacetylase

or a pharmaceutically acceptable salt, hydrate, solvate, or prodrug thereof, wherein U, J, V, X, R2a, R2b, R2c, R5 and t are as described herein. The present invention relates generally to inhibitors of histone deacetylase and to methods of making and using them. These compounds are useful for promoting cognitive... The General Hospital Corporation D b a Massachuset

Inhibitors of histone deacetylase

or a pharmaceutically acceptable salt, hydrate, solvate, or prodrug thereof, wherein X1, X2, X3, X4, X5, W1, W2, W3, and W4 are as described herein. The present invention relates generally to inhibitors of histone deacetylase and to methods of making and using them. In one aspect, the invention relates to... The General Hospital Corporation D b a Massachuset

Inhibitors of histone deacetylase

... The General Hospital Corporation D b a Massachuset

Compositions of microbiota and methods related thereto

Methods and compositions are provided for treating weight related conditions and metabolic disorders by altering microbiota in a subject. One aspect provides methods and compositions to alter microbiota in a subject by administering to the subject a composition that includes a substantially purified microbiota from phyla such as Bacteroidetes, Proteobacteria,... The General Hospital Corporation D b a Massachuset

Immunomodulating compositions and methods of use thereof

This invention is directed to β-1-6-glucans, compositions and devices comprising the same, and methods of use thereof in modulating immune responses. The β-1-6-glucans of certain embodiments of the invention are enriched for O-acetylated groups and/or conjugated to a solid support or linked to a targeting moiety.... The General Hospital Corporation D b a Massachuset

Methods and devices for activating brown adipose tissue using electrical energy

Methods and devices are provided for activating brown adipose tissue (BAT). Generally, the methods and devices can activate BAT to increase thermogenesis, e.g., increase heat production in the patient, which over time can lead to weight loss. In one embodiment, a medical device is provided that activates BAT by electrically... The General Hospital Corporation D b a Massachuset

Uses of salt-inducible kinase (sik) inhibitors

The present disclosure provides methods of treating and/or preventing inflammatory bowel disease (IBD) and graft-versus-host disease (GVHD) using salt-inducible kinase (SIK) inhibitors, such as macrocyclic SIK inhibitors of Formula (I), imidazolyl SIK inhibitors of Formula (II), and urea and carbamate SIK inhibitors of Formula (III-A) (e.g., urea and carbamate SIK... The General Hospital Corporation D b a Massachuset

Inhibitors of histone deacetylase

... The General Hospital Corporation D b a Massachuset

Compositions for treating or preventing obesity and insulin resistance disorders

Provided herein are methods and compositions for modulating the activity or level of a sirtuin, thereby treating or preventing obesity or an insulin resistance disorder, such as diabetes in a subject. Exemplary methods comprise contacting a cell with a sirtuin activating compound or an inhibitory compound to thereby increase or... The General Hospital Corporation D b a Massachuset

Methods for the prevention and treatment of burn injuries and secondary complications

The disclosure relates to methods for treating a subject suffering from a burn injury or associated complications by administering to the subject an effective amount of an aromatic-cationic peptide. For example, a burn injury may be associated with distant pathophysiological effects, such as hypermetabolism, skeletal muscle dysfunction, and organ damage.... The General Hospital Corporation D b a Massachuset

Inhibitors of histone deacetylase

... The General Hospital Corporation D b a Massachuset

Phenotype-based chemical screens

Embodiments of the present invention provide materials and methods for performing phenotype-based chemical screens. Embodiments disclosed herein pertain to the use of a battery of high-throughput zebrafish behavioral assays to generate behavioral profiles. In accordance with these embodiments, responses to various chemical compounds with known and unknown biological functions can... The General Hospital Corporation D b a Massachuset

Methods and devices for activating brown adipose tissue with targeted substance delivery

Methods and devices are provided for activating brown adipose tissue with targeted substance delivery. Generally, the methods and devices can activate BAT to increase thermogenesis, e.g., increase heat production in the patient, which over time can lead to weight loss and/or improved metabolic function. In one embodiment, a chemical configured... The General Hospital Corporation D b a Massachuset

Biomarkers of response to nae inhibitors

Disclosed herein are markers whose mutational status is associated with sensitivity to treatment with NAE inhibitors. Mutational status is determined by measurement of characteristics of markers associated with the marker genes. Compositions and methods are provided to assess markers of marker genes to predict response to NAE inhibition treatment.... The General Hospital Corporation D b a Massachuset

Methods for treating cancer resistant to erbb therapeutics

Provided herein are methods for treating cancer that is resistant to treatment with an anti-ErbB therapeutic agent and which is associated with an activating MET gene mutation or a MET gene amplification. The methods involve administering to a subject a combination of an anti-ErbB therapeutic and an anti-MET therapeutic. Also... The General Hospital Corporation D b a Massachuset

Systems and methods for droplet tagging

The present invention generally relates to microfluidic devices, including systems and methods for tagging droplets within such devices. In some aspects, microfluidic droplets are manipulated by exposing the droplets (or other discrete entities) to a variety of different conditions. By incorporating into the droplets a plurality of nucleic acid “tags,”... The General Hospital Corporation D b a Massachuset

Methods for diagnosis and prognosis of epithelial cancers

The present invention is based on the discovery that three proteins, Cystatin B, Chaperonin 10, and Profilin are present in the urine of patients with bladder cancer, a cancer of epithelial origin. Accordingly, the present invention is directed to methods for prognostic evaluation of cancers of epithelial origin and to... The General Hospital Corporation D b a Massachuset

Brown adipocyte modification

Methods and therapeutics are provided for treating metabolic disorders by increasing activation of brown adipose tissue. Generally, the methods and therapeutics can increase activation of brown adipose tissue to increase energy expenditure and induce weight loss. In one embodiment, a method for increasing activation of brown adipose tissue includes modifying... The General Hospital Corporation D b a Massachuset

Cancer-related extracellular matrix signatures and related methods and products

... The General Hospital Corporation D b a Massachuset

Cancer-related extracellular matrix signatures and related methods and products

Proteomic methods for identifying cancer related proteins and related products and kits are provided. The cancer specific proteins are extracellular matrix proteins that are associated with various aspects of cancer. Panels or signature sets of proteins useful in the detection, diagnosis and treatment of cancers as well as monitoring therapeutic... The General Hospital Corporation D b a Massachuset

Methods and systems for droplet tagging and amplification

The present invention generally relates to microfluidic devices, including methods and systems for tagging droplets within such devices. In some aspects, microfiuidic droplets are manipulated by exposing the droplets (or other discrete entities) to a variety of different conditions. By incorporating into the droplets a plurality of nucleic acid “tags,”... The General Hospital Corporation D b a Massachuset

Clinical predictors of weight loss

Methods and compositions are generally provided for treating metabolic disorders, e.g., obesity. One aspect discloses methods and compositions for obtaining a biological sample from the subject, evaluating the sample for the presence or absence of a genetic indicator, wherein the genetic indicator is selected from a single nucleotide polymorphism and... The General Hospital Corporation D b a Massachuset








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