Real Time Touch



new TOP 200 Companies filing patents this week

new Companies with the Most Patent Filings (2010+)




Real Time Touch

Similar
Filing Names

The General Hospital Corporation
The General Hospital Corporation D b a Massachusetts General Hospital
The General Hospital Corporation Dba Massachusetts General Hospital
The General Hospital Corporation A Massachusetts Corporation
The General Hospital Corporation D b a
The General Hospital Corporation D b a Massachusettes General Hospital
The General Hospital Corporation D b a Massachusets General Hospital
The General Hospital Corporation D b a Massachuset General Hospital
The General Hospital Corporation D b a Massachuseets General Hospital
The General Hospital Corporation D b a Massachuset Ts General Hospital
The General Hospital Corporation D b a Massachusetts Gerneral Hospital
The General Hospital Corporation_20100121
The General Hospital Corporation Inc
The General Hospital Corporation Dba Massachusetts Ceneral Hospital
The General Hospital Corporation D b a Massachussetts General Hospital
The General Hospital Corporation D b a Massachusettls General Hospital

The General Hospital Corporation patents


Recent patent applications related to The General Hospital Corporation. The General Hospital Corporation is listed as an Agent/Assignee. Note: The General Hospital Corporation may have other listings under different names/spellings. We're not affiliated with The General Hospital Corporation, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "T" | The General Hospital Corporation-related inventors


 new patent  Compositions and methods for in vivo imaging

This document relates to compounds useful for targeting PARP1. Also provided herein are methods for using such compounds to detect and image cancer cells.... The General Hospital Corporation

 new patent  Spectrally encoded probe with multiple diffraction orders

A spectrally encoded endoscopic probe. The probe has a light guiding component, a light focusing component, and a grating component. The probe is configured such that a set of light beams of multiple wavelengths are diffracted by the grating component in different orders at substantially the same angle. The set... The General Hospital Corporation

Method and dermatological treatment

Exemplary methods and systems can be provided for resurfacing of skin that include formation of a plurality of small holes, e.g., having widths greater than about 0.2 mm and less than about 0.7 mm or 0.5 mm, using a mechanical apparatus. Compressive and/or tensile forces can then be applied to... The General Hospital Corporation

System and stimulating hair growth

A system and method are provided for stimulating hair growth of a user. The system includes a stimulating unit in communication with a control unit. The stimulating unit includes at least one electrode to be placed on a region of the user, a pulser configured to send electronic pulses to... The General Hospital Corporation

Spectrally-encoded endoscopy techniques, apparatus and methods

Exemplary apparatus for method for forming at least one spectral encoding endoscopy configuration. For example, it is possible to modify a spacer configuration and an lens optics configuration to have respective predetermined lengths, and also to modify a dispersive optics configuration to have a further predetermined length. Further, the modified... The General Hospital Corporation

Medical simulation apparatus

Systems and methods for simulating medical procedures are provided. In one example, systems and methods are provided for a neck simulator that presents realistic interactions with the neck during medical procedures, including injections, such as may be performed during a laryngeal injection.... The General Hospital Corporation

Prevention and treatment of itch with an mrgpr antagonist

Embodiments described herein relates to compositions and methods of preventing and/or treating itch in a subject using a therapeutically effective amount of a MRG receptor antagonist. e.g., a tripeptide QWF. In one embodiment, the itch is a non-histamine mediated itch.... The General Hospital Corporation

Methods for profiling the t cell repertoire

The present disclosure relates to methods for profiling subject specific and personalized T cell receptor (TCR) repertoires using a single-cell sequencing method. More particularly, disclosed are methods for determining binding of T cell receptors to subject specific neoantigens. In addition, the techniques herein may identify the antigenic targets of T... The General Hospital Corporation

Methods, arrangements and systems for obtaining information associated with an anatomical sample using optical microscopy

Arrangements and methods are provided for obtaining information associated with an anatomical sample. For example, at least one first electro-magnetic radiation can be provided to the anatomical sample so as to generate at least one acoustic wave in the anatomical sample. At least one second electro-magnetic radiation can be produced... The General Hospital Corporation

Devices, systems, methods and storage mediums using full range optical coherence tomography

One or more devices, systems, methods and storage mediums for performing continuously, full range optical coherence tomography (OCT) without losing A-lines are provided. Examples of such applications include imaging, evaluating and diagnosing biological objects, such as, but not limited to, for cardio and/or ophthalmic applications, and being obtained via one... The General Hospital Corporation

Systems, methods and computer-accessible medium which provide microscopic images of at least one anatomical structure at a particular resolution

Exemplary embodiments of systems and methods can be provided which can generate data associated with at least one portion of a sample. For example, at least one first radiation can be forwarded to the portion through at least one optical arrangement. At least one second radiation can be received from... The General Hospital Corporation

Optical sensor conjugates for detecting reactive oxygen and/or reactive nitrogen species in vivo

The present invention provides methods and compositions based on optical sensor conjugates that are useful for detecting reactive oxygen, reactive nitrogen, or both species that are a direct result of inflammation caused by tissue damage.... The General Hospital Corporation

Isolated human lung progenitor cells and uses thereof

Provided herein are methods and compositions relating, in part, to the generation of human progenitor cells committed to the lung lineage and uses of such cells for treatment of lung diseases/disorders or injury to the lung. Whether an adult stem cell can be isolated from human adult lung remains controversial... The General Hospital Corporation

Rapid quantitative detection of single nucleotide polymorphisms or somatic variants and methods to identify malignant neoplasms

Provided are systems, kits, and methods for the quantitative detection of single nucleotide polymorphisms or variants to identify malignant neoplasms. The methods include use of modified oligonucleotide blockers with peptide nucleic acid backbones that hybridize to and block logarithmic amplification of the wild-type alleles of a target, and incorporation of... The General Hospital Corporation

Collagen targeted imaging probes

Disclosed herein are collagen-targeted imaging agents for positron emission tomography and related imaging methods using the collagen-targeted imaging agents. The collagen-targeted imaging agent is a cyclic polypeptide comprising a cyclic main body, wherein the cyclic main body comprises at least one S—S bond; at least two branches, wherein each of... The General Hospital Corporation

Metabolic labeling and molecular enhancement of biological materials using bioorthogonal reactions

The present application provides methods of functionalizing an organ or tissue of a mammal by administering a nutrient (e.g., peracetylated N-azido galactosamine Ac4GalNAz) to the mammal or by culturing an organ or tissue in a bioreactor containing such nutrient. The present application also provides methods of selectively functionalizing extracellular matrix... The General Hospital Corporation

Methods and compositions for regulating iron homeostasis by modulation of bmp-6

Modulation of iron homeostasis by regulating BMP-6 activity is provided. Methods of using BMP-6 and BMP-6 protein-specific reagents, such as antibodies, for altering serum iron levels in humans are provided. Such antibodies are useful in pharmaceutical compositions for the prevention and treatment of hemochromatosis and anemia of inflammation.... The General Hospital Corporation

Spectrally encoded endoscopic probe having a fixed fiber

Exemplary apparatus, systems, methods of making, and methods of using a configuration in an optical arrangement for spectrally encoded endoscopy (SEE) probe can be provided. For example, the probe can comprise a fixed guiding portion and a rotatable dispersive portion.... The General Hospital Corporation

Biomarkers of cancer

Methods for diagnosing cancer based on detecting the presence of increased levels of expression of satellite repeats and/or Line-1.... The General Hospital Corporation

Compounds, systems, and methods for monitoring and treating a surface of a subject

Compounds, systems, and methods are provided for the design and assembly of a non-invasive, analyte sensing dressing. The dressing can be therapeutic. The dressing includes a sensor and a matrix. The sensor is capable of detecting analytes such as molecular oxygen, carbon dioxide, nitric oxides, dissolved analytes in plasma, and... The General Hospital Corporation

Histone deacetylase inhibitors

Provided herein are brain penetrant histone deacetylase (HDAC) inhibitors useful for treating diseases or disorders associated with HDAC. An exemplary HDAC inhibitor provided herein exhibits a brain-to-plasma ratio of 20:1. Pharmaceutical compositions comprising HDAC inhibitors and methods for treating diseases associated with HDAC are also provided.... The General Hospital Corporation

Diagnosis and monitoring treatement of prostate cancer

Provided herein are assays and methods related to determining a ratio of expression levels of PSA/PSMA or determining the expression level of PSMA in circulating tumor cells for diagnosis and/or for the purpose of monitoring treatment efficacy for prostate cancers that are likely hormone resistant.... The General Hospital Corporation

Photoactivatable caged tamoxifen and tamoxifen derivative molecules and methods of use thereof

Provided herein are compositions containing photoactivatable caged tamoxifen and tamoxifen derivative molecules. Also provided are kits containing one of these compositions and a light source. Also provided are methods of optically inducing nuclear translocation of a fusion protein containing a mammalian estrogen receptor ligand binding domain in a eukaryotic cell... The General Hospital Corporation

Anti-chondroitin sulfate proteoglycan 4 antibodies and uses thereof

Described herein are antibodies that bind chondroitin sulfate proteoglycan 4 (CSPG4) and, in particular, chimeric and humanized anti-CSPG4 antibodies and fragments thereof. Also provided herein are methods of using individual humanized antibodies or compositions thereof for the detection, prevention, and/or therapeutic treatment of CSPG4-related diseases, in particular, melanoma.... The General Hospital Corporation

Microfluidic droplet encapsulation

Microfluidic devices and methods for the encapsulation of particles within liquid droplets are disclosed. The new methods and devices form 1-100 picoliter-size monodisperse droplets containing the particles, such as single cells, encapsulated in individual liquid droplets. The particles can be encapsulated in droplets of a fluid by passing a fluid... The General Hospital Corporation

Nucleic acid constructs and methods for labeling and detecting nucleosomal dna modifications

Embodiments disclosed herein provide methods for identifying cell-type-specific nucleosomal DNA modifications. The methods leverage nucleosomal DNA barcoding and pool-and-split multiplexing to provide high-throughout, quantitative profiling of nucleosomal DNA states. The methods enable the profiling of multiple nucleosomal DNA marks across different cell types and/or conditions thereby linking quantitative changes in... The General Hospital Corporation

Deep brain source imaging with m/eeg and anatomical mri

A method for non-invasively resolving electrophysiological activity in sub-cortical structures located deep in the brain by comparing amplitude-insensitive M/EEG field patterns arising from activity in subcortical and cortical sources under physiologically relevant sparse constraints is disclosed. The method includes a sparse inverse solution for M/EEG subcortical source modeling. Specifically, the... The General Hospital Corporation

Compositions and methods for the prevention and treatment of autoimmune conditions

The methods include selectively reducing or expanding T cells according to the antigenic specificity of the T cells. Therefore, the present invention can be used to reduce or eliminate pathogenic T cells that recognize autoantigens, such as beta cell specific T cells. As such, the present invention can be used... The General Hospital Corporation

F-18 labeled tracer and methods of manufacture

A method of producing a radiofluorinated compound comprising the steps of forming a reaction mixture comprising a reactant having a formula of R—Y and a radiofluorinating agent having a formula of R′—18F; and contacting the reaction mixture with microwave radiation to achieve a temperature of between 100° C. and 250°... The General Hospital Corporation

Inhibitors of the mitf molecular pathway

as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful as MITF inhibitors, MITF pathway inhibitors and for the treatment of cancer.... The General Hospital Corporation

Methods for modulating atrx-dependent gene repression

Methods and compositions for modulation of the activity of alpha thalassemia/mental retardation syndrome X-linked (ATRX), e.g., modulation of DNA-ATRX or RNA-ATRX interactions, and methods for identifying and using compounds that modulate DNA-ATRX or RNA-ATRX interactions, as well as the compounds themselves.... The General Hospital Corporation

Methods for treating neurodegenerative diseases

Methods for treating, and for identifying novel treatments for, neurodegenerative diseases, as well as animal and cellular models. The present disclosure shows that age dependent accumulation of genomic lesions leads to the production of RNA molecules within neurons that mimic viruses and intrinsically activate innate immune signaling, which triggers neurodegeneration.... The General Hospital Corporation

Methods and compositions for treating amyloid deposits

The present disclosure provides methods of determining A-beta in a mammal before and after treatment of an amyloid disorder, comprising obtaining a first blood sample from the mammal; administering to the mammal a treatment for an amyloid disorder; obtaining a second blood sample from the mammal; quantifying a level of... The General Hospital Corporation

Advanced functional biocompatible polymer putty used as a hemostatic agent for treating damaged tissue and cells

A hemostatic putty for treatment of a variety of wounds topographies, including but not limited to highly three dimensional wounds, for example gunshot wounds and impalements, is disclosed. The putty is comprised of a matrix polymer weakly crosslinked or not crosslinked such that a viscoelastic matrix is formed. The viscoelastic... The General Hospital Corporation

11/16/17 / #20170326244

Biotin complexes for treatment and diagnosis of alzheimer's disease

Described herein are compositions and methods for treating or imaging Alzheimer's disease (AD). The compositions comprise a biotin moiety and a siRNA moiety, without the need for a targeting agent such as an antibody, avidin, or streptavidin. In certain embodiments, the compositions further comprise a diagnostic agent.... The General Hospital Corporation

11/16/17 / #20170326273

Human airway stem cells in lung epithelial engineering

Methods of using human airway stem cells in lung epithelial engineering, optionally wherein the cells are contacted with a gamma secretase inhibitor, bioartificial airway organs produced thereby, and the use thereof, e.g., for transplantation. Also methods of treating a bio-artificial matrix with Tenascin-C and/or fibrillin 2.... The General Hospital Corporation

11/16/17 / #20170326293

Syringe infusion pump

An infusion apparatus for use with a syringe includes a housing enclosing a drivetrain. The drivetrain includes a pinion, spur gears, and a worm gear. One spur gear is arranged to engage with the pinion and another spur gear is arranged to engage with the worm gear. The housing also... The General Hospital Corporation

11/16/17 / #20170327804
11/16/17 / #20170327805

Using rna-guided foki nucleases (rfns) to increase specificity for rna-guided genome editing

Methods for increasing specificity of RNA-guided genome editing, e.g., editing using CRISPR/Cas9 systems.... The General Hospital Corporation

11/16/17 / #20170327806

Engineered crispr-cas9 nucleases with altered pam specificity

Engineered CRISPR-Cas9 nucleases with altered and improved PAM specificities and their use in genomic engineering, epigenomic engineering, and genome targeting.... The General Hospital Corporation

11/16/17 / #20170327823

Selective reactivation of genes on the inactive x chromosome

Methods and compositions for selectively reactivating genes on the inactive X chromosome (Xi) in a locus-specific manner, e.g., genes associated with X-linked diseases, e.g., Rett Syndrome, Factor VIII or IX deficiency, Fragile X Syndrome, Duchenne muscular dystrophy, and PNH, in heterozygous females.... The General Hospital Corporation

11/16/17 / #20170328971

Method for simultaneous time-interleaved multislice magnetic resonance imaging

Methods for reducing scan time in magnetic resonance imaging (“MRI”), particularly when imaging three-dimensional image volumes, using a simultaneous time-interleaved multislice (“STIMS”) acquisition are described. The unused time in each repetition time (“TR”) period is exploited to provide an additional reduction in encoding time for a three-dimensional acquisition (e.g., a... The General Hospital Corporation

11/09/17 / #20170319071

System, utilizing optical dispersion for fourier-domain optical coherence tomography

An apparatus can be provided which can include a laser arrangement which can be configured to provide a laser radiation, and can include an optical cavity. The optical cavity can include a dispersive optical first arrangement which can be configured to receive and disperse at least one first electro-magnetic radiation... The General Hospital Corporation

11/09/17 / #20170319378

Treatment systems for removing heat from subcutaneous lipid-rich cells and treatment systems for affecting subcutaneous lipid-rich cells

The present invention relates to methods for use in the selective disruption of lipid-rich cells by controlled cooling. The present invention further relates to a device for use in carrying out the methods for selective disruption of lipid-rich cells by controlled cooling.... The General Hospital Corporation

11/09/17 / #20170319517

Methods, compositions, and kits for treating pain and pruritis

The invention features a method for inhibiting one or more voltage-gated ion channels in a cell by contacting the cell with (i) a first compound that activates a channel-forming receptor that is present on nociceptors and/or pruriceptors; and (ii) a second compound that inhibits one or more voltage-gated ion channels... The General Hospital Corporation

11/09/17 / #20170319676

Antifugetactic agents for the treatment of cancers

This invention provides methods and compositions for modulating movement of eukaryotic cells with migratory capacity. More specifically, the invention provides fugetactic agents and methods for the use thereof in enhancing an immune response.... The General Hospital Corporation

11/09/17 / #20170319776

System and guided removal from an in vivo subject

In accordance with some configurations, systems and methods for guided removal from an in vivo subject are provided. In some configurations, a method for removing an object is provided. The method comprising, guiding a flexible tube through a passageway of an in vivo subject, wherein the flexible tube comprises at... The General Hospital Corporation

11/09/17 / #20170322079

Simple monolithic optical element for forward-viewing spectrally encoded endoscopy

Exemplary spectrally encoded probes are provided having forward view capabilities. These probes are configured such that the detection element comprises a plurality of light collecting components, where the distal ends at least partially surround the illumination element and the proximal ends form a linear array that is optically connected to... The General Hospital Corporation

11/09/17 / #20170322279

Multi-shot echo planar imaging using reordered segments and rf excitation pulse phase and slice profiles matched across interleaves

Described here are systems and methods for producing images with a magnetic resonance imaging (“MRI”) system using a high-resolution, motion-robust, artifact-free segmented echo planar imaging (“EPI”) technique. In particular, a fast low angle excitation echo planar imaging technique (“FLEET”) using variable flip angle (“VFA”) radio frequency (“RF”) excitation pulses that... The General Hospital Corporation

11/02/17 / #20170312314

System for treating a sebaceous gland

One aspect of the invention provides a system of treating a sebaceous gland in human skin with light energy to reduce acne symptoms. The system includes: a composition comprising a metallic nanoparticle dispersed within a carrier; means to vibrate at least a portion of the skin surface to which the... The General Hospital Corporation

11/02/17 / #20170313765

Direct expression of antibodies

The present invention relates to methods exogenous nucleic acid molecules, such as RNA, that encode an antibody or antigen-binding fragment of an antibody, and optionally encode a cellular modulation factor and/or a potentiation factor. The cellular modulation factor is a factor that results in increased expression of the antibody and/or... The General Hospital Corporation

11/02/17 / #20170313767

Methods of diagnosis and treatment of tuberculosis and infection

Described herein are methods of treating, diagnosing, and/or prognosing a disease in a subject relating to detection of the glycosylation state of the antibodies present in the subject. In some embodiments, the disease can be an infection. In some embodiments, an antibody glycosylation state that is indicative of the presence... The General Hospital Corporation

11/02/17 / #20170314075

Use of microvesicles in diagnosis and prognosis of medical diseases and conditions

The presently disclosed subject matter is directed to methods of aiding diagnosis, prognosis, monitoring and evaluation of a disease or other medical condition in a subject by detecting a biomarker in microvesicles isolated from a biological sample from the subject.... The General Hospital Corporation

10/26/17 / #20170303941

System and guided removal from an in vivo subject

In accordance with some configurations, systems and methods for guided removal from an in vivo subject are provided. In some configurations, a method for removing an object is provided. The method comprising, guiding a flexible tube through an in vivo subject's ureter, wherein the flexible tube comprises at least a... The General Hospital Corporation

10/26/17 / #20170304245

Compounds for the treatment of obesity and methods of use thereof

Pentacyclic triterpene weight loss agents are provided herein. Also provided are pharmaceutical formulations containing a therapeutically effective amount of one or more of the weight loss agents, or pharmaceutically acceptable salts or prodrugs thereof, in combination with one or more pharmaceutically acceptable excipients. The pharmaceutical formulations can be administered to... The General Hospital Corporation

10/26/17 / #20170304400

Methods for preventing fibrosis using cxcr4 and/or cxcr7 binding agents

This disclosure is directed to methods of treating a subject with a fibrotic or fibroproliferative disease, comprising administering to the subject a composition comprising an effective amount of an anti-fibrosis agent, e.g., a CXCR4 and/or CXCR7 binding agent, such as CXCL12.... The General Hospital Corporation

10/26/17 / #20170305866

Histone deacetylase 6 selective inhibitors for the treatment of bone disease

This invention relates to methods for treating bone disease associated with osteoclast activation using HDAC6 selective inhibitors, e.g., small molecule inhibitors such as reverse amide compounds.... The General Hospital Corporation

10/26/17 / #20170307595

Methods and devices to study metabolism

Methods and devices to screen test compounds, e.g., study metabolism of test compounds, e.g., a pro-drug, by one cell, e.g., a hepatocyte, and the effect of metabolism of the test compound by the first cell on a second cell, e.g., a cancer cell, are described.... The General Hospital Corporation

10/19/17 / #20170296322

Fabrication of vascularized tissue using microfabricated two-dimensional molds

Methods and materials for making complex, living, vascularized tissues for organ and tissue replacement, especially complex and/or thick, structures, such as liver tissue is provided. Tissue lamina is made in a system comprising an apparatus having (a) a first mold or polymer scaffold, a semi-permeable membrane, and a second mold... The General Hospital Corporation

10/19/17 / #20170299683

Rapid measurement of perfusion using optimized magnetic resonance fingerprinting

Described here are systems and methods for generating quantitative perfusion parameter maps based on different longitudinal relaxation parameter maps that are produced from images acquired using non-selective and selective magnetic resonance imaging (“MRI”) data acquisition techniques.... The General Hospital Corporation

10/12/17 / #20170290499

Imaging system, method and distal attachment for multidirectional field of view endoscopy

An exemplary apparatus for imaging at least one anatomical structure can be provided. For example, the apparatus can include an endoscopic first arrangement, a radiation source second arrangement which provides at least one electro-magnetic radiation, and a third arrangement attached to at least one portion of the endoscopic arrangement. The... The General Hospital Corporation

10/12/17 / #20170290541

Neurodegenerative disease screening using an olfactometer

Systems and methods of the present invention provide for an olfactometer for delivering one or more odors and one or more computing devices configured to: receive user input for an odor memory test and an odor discrimination test; calculate a score for the odor memory test and the odor discrimination... The General Hospital Corporation

10/12/17 / #20170290797

Combination therapies for the treatment of alzheimer's disease and related disorders

The present invention relates to combination therapies for treating Alzheimer's disease or an amyloidosis-associated pathological condition comprising co-administering a therapeutically effective amount of a first compound, and a therapeutically effective amount of a second compound. In certain embodiments, the first compound or the second compound inhibits AB peptide polymerization; is... The General Hospital Corporation

10/12/17 / #20170290908

Viral vectors and their use in therapeutic methods

The invention provides viral vectors (e.g., herpes viral vectors) and methods of using these vectors to treat disease.... The General Hospital Corporation

Patent Packs
10/12/17 / #20170292942

Biomarkers of cancer

Methods for diagnosing cancer and monitoring treatment efficacy based on detecting the presence of increased levels of expression of satellite correlated genes.... The General Hospital Corporation

10/05/17 / #20170281203

Non-lithotripsic kidney-stone therapy

... The General Hospital Corporation

10/05/17 / #20170281946

Systems and methods for patient rehabilitation using brain stimulation

Systems and methods are provided for stimulating the brain of a patient to treat a medical condition. In some aspects, a method includes positioning a stimulating device comprising electrical contacts configured to electrically stimulate locations associated with a patient's brain, and initiating a rehabilitation process to include the patient performing... The General Hospital Corporation

09/28/17 / #20170273611

Systems and methods for discovery and characterization of neuroactive drugs

Systems and methods for discovery and characterization of neuroactive drugs are provided. In some aspects, a method for evaluating an effectiveness of a drug administered to a subject includes receiving neurophysiological data acquired from a subject under an administration of a drug, and analyzing the neurophysiological data to generate signatures... The General Hospital Corporation

09/28/17 / #20170273799

Methods and devices for knee joint replacement with anterior cruciate ligament substitution

Methods and devices are provided for knee joint replacement with anterior cruciate ligament (ACL) substitution. Generally, the methods and devices can allow a knee joint to be partially or totally replaced in conjunction with substitution of the knee joint's ACL. In one embodiment, a knee replacement prosthesis can include a... The General Hospital Corporation

09/28/17 / #20170273930

Methods to treat neurodegenerative diseases

The specification provides compositions and methods to treat neurodegenerative diseases.... The General Hospital Corporation

09/28/17 / #20170273951

Anesthetic compounds and related methods of use

Provided herein is also a pharmaceutical composition comprising a compound according to formula (I) and a pharmaceutically acceptable carrier, and a method for providing anesthesia in a subject by administering such a pharmaceutical composition.... The General Hospital Corporation

09/28/17 / #20170274011

Injectable slurries and methods of manufacturing and using the same

One aspect of the invention provides a slurry comprising: a plurality of sterile ice particles having a largest cross-sectional dimension less than about 1.5 mm; and a biocompatible surfactant. Another aspect of the invention provides a slurry including: a plurality of sterile ice particles having a largest cross-sectional dimension less... The General Hospital Corporation

09/28/17 / #20170274078

Compositions and methods for treatment of neurological disorders

Described herein are compositions comprising, and methods for using, biocompatible cold slurries and methods of administering the same to provide reversible inhibition of peripheral nerves in a subject in need thereof.... The General Hospital Corporation

09/28/17 / #20170274174

System and administering, monitoring and controlling biomimetic sleep

Systems and methods for inducing natural sleep in a subject is provided. In some aspects, the method includes inducing a first sleep state; monitoring a first plurality of characteristics of a brain of the subject to verify the subject is in the first sleep state; inducing a second sleep state... The General Hospital Corporation

09/28/17 / #20170275669

Methods, kits, and systems for multiplexed detection of target molecules and uses thereof

Described herein are methods, compositions, kits and systems for multiplexed detection of target molecules from a sample. In some embodiments, the methods, compositions, kits and systems can be used to perform multiplexed protein analysis of a sample (e.g., a sample comprising a small number of cells or a single-cell sample).... The General Hospital Corporation

09/28/17 / #20170276753

Simultaneous dynamic contrast enhanced and dynamic susceptibility magnetic resonance imaging using magnetic resonance fingerprinting

Described here are systems and methods for generating quantitative perfusion parameter maps based on multiple different relaxation parameter maps that are simultaneously produced from images acquired using contrast-enhanced magnetic resonance imaging (“MRI”) techniques.... The General Hospital Corporation

09/28/17 / #20170276755

System and dual-kernel image reconstruction

A method and imaging system is provided that can control a magnetic gradient system and an RF system of an MRI system according to a calibration pulse sequence to acquire positive readout gradient (RO+) data and negative readout gradient (RO−) data. The RO+ data and the RQ− data are assembled... The General Hospital Corporation

09/21/17 / #20170266377

Prediction, visualization, and control of drug delivery by multiple infusion pumps

The subject technology is embodied in a method for predicting a delivery rate of a plurality of drugs dispensed by multiple infusion pumps at a delivery point. The method includes receiving one or more operating parameters related to multiple drug pumps and a carrier fluid pump, wherein each of the... The General Hospital Corporation

09/14/17 / #20170259023

Closed-circuit breathing device

Described here are closed-circuit breathing devices and methods for their use. In general, the closed-circuit breathing device is configured to achieve a steady-state equilibrium, whereby therapeutic gas is introduced into the breathing circuit in small, controlled volumes until a steady state concentration of the therapeutic gas is reached. During this... The General Hospital Corporation

Patent Packs
09/14/17 / #20170259467

Methods for making oxidation resistant polymeric material

The present invention relates to methods for making oxidation resistant medical devices that comprise polymeric materials, for example, ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making antioxidant-doped medical implants, for example, doping of medical devices containing cross-linked UHMWPE with vitamin E by diffusion and materials used... The General Hospital Corporation

09/14/17 / #20170260245

Tumor necrosis factor superfamily and tnf-like ligand muteins and methods of preparing and using the same

The invention features homo-multimers, e.g., homo-trimers, of TNFSF or TNF-like ligand muteins in which each TNFSF ligand or TNF-like ligand mutein monomer contains at least one cysteine residue substitution or insertion that promotes the formation of a disulfide bond with a cysteine residue on a neighboring TNFSF or TNF-like ligand... The General Hospital Corporation

09/14/17 / #20170260286

Antigen-binding fusion proteins with modified hsp70 domains

The invention relates to fusion proteins comprising an antigen binding domain fused with a modified heat shock 70 protein. The invention further relates to methods of using the fusion proteins to induce an immune response to antigens and to treat diseases associated with antigens.... The General Hospital Corporation

09/14/17 / #20170260565

Propeptide-luciferase fusion proteins and methods of use thereof

The present invention provides nucleic acid constructs that encode fusion peptides comprising a bioluminescent protein and a precursor of a secreted peptide or protein expressed at the cell surface and high throughput screening assays using same.... The General Hospital Corporation

09/14/17 / #20170261578

Systems and methods for designing magnetic resonance fingerprinting imaging parameters

Systems and methods for acquiring magnetic resonance fingerprinting (MRF) imaging data from a subject using a magnetic resonance imaging (MRI) system are provided. The method includes receiving an indication of an MRF imaging process to be performed by the MRI system and receiving a desired design objective for the MRF... The General Hospital Corporation

09/07/17 / #20170252327

Methods of modulating gastrointestinal tract flora levels with alkaline phosphatase

This invention relates generally to a therapeutic use of alkaline phosphatase to modulate gastrointestinal tract flora levels in subject.... The General Hospital Corporation

09/07/17 / #20170253931

Post-treatment breast cancer prognosis

The disclosure includes the identification and use of gene expression profiles, or patterns, with clinical relevance to extended treatment and cancer-free survival in a patient. In particular, the disclosure includes the identities of genes that are expressed in correlation with benefit in a switch in endocrine therapy used to treat... The General Hospital Corporation

09/07/17 / #20170254749

Systems and methods for obtaining information associated with an anatomical sample using optical microscopy

This disclosure provides systems and methods for mapping and/or measuring a mechanical property of a medium. The mechanical property can be measured by Brillouin spectroscopy. The systems and methods can include a three-dimensional imaging modality that is co-registered with a Brillouin probe beam of a Brillouin spectrometer. The three-dimensional imaging... The General Hospital Corporation

08/31/17 / #20170246180

Acyclic cucurbit[n]uril type molecular containers to treat intoxication and decrease relapse rate in substance abuse disorders

Provided are methods for reversing the effects of drugs of abuse. The method involves administering acyclic CB[n]-type compounds to a mammal in need of the reversal of the effects from a drug of abuse.... The General Hospital Corporation

08/31/17 / #20170246250

Eluting matrix and uses thereof

CXCL12 polypeptide eluting matrices encapsulating at least one cell are described for use in the treatment of autoimmune disorders.... The General Hospital Corporation

08/31/17 / #20170247383

Neuroactive compounds and methods of using the same

The invention described herein relates generally to neuroactive compounds and compositions for the treatment psychotic disorders, methods for treating psychosis using these neuroactive compounds, and methods for screening for novel neuroactive compounds. Certain aspects are directed to a family of compounds called “finazines.” Certain aspects are directed to in vivo... The General Hospital Corporation

08/31/17 / #20170248518

Laser speckle micro-rheology in characterization of biomechanical properties of tissues

Laser speckle microrheology is used to determine a mechanical property of a biological tissue, namely, an elastic modulus. Speckle frames may be acquired by illuminating a coherent light and capturing back-scattered rays in parallel and cross-polarized states with respect to illumination. The speckle frames may be analyzed temporally to obtain... The General Hospital Corporation

08/31/17 / #20170248532

Methods and x-ray imaging from temporal measurements

For each X-ray path through a tissue, numerous trials are conducted. In each trial, X-ray photons are emitted along the path until a Geiger-mode avalanche photodiode “clicks”. A temporal average—i.e., the average amount of time elapsed before a “click” occurs—is calculated. This temporal average is, in turn, used to estimate... The General Hospital Corporation

08/24/17 / #20170238809

Methods and systems for optical imaging or epithelial luminal organs by beam scanning thereof

Arrangements, apparatus, systems and systems are provided for obtaining data for at least one portion within at least one luminal or hollow sample. The arrangement, system or apparatus can be (insertable via at least one of a mouth or a nose of a patient. For example, a first optical arrangement... The General Hospital Corporation

08/24/17 / #20170241991

System and in vitro blood vessel modeling

The present invention provides an in vitro blood vessel model for investigation of drug induced vascular injury and other vascular pathologies. The in vitro blood vessel model provides two channels separated by a porous membrane that is coated on one side by an endothelial cell layer and is coated on... The General Hospital Corporation

08/17/17 / #20170231519

System and annotating and analyzing eeg waveforms

Systems and methods of the present invention provide for storing an annotated set of confirmed epileptiform discharges (ED) waveforms in a database; receiving, by a computing device, a signal encoding electroencephalograph (EEG) data from a plurality of electrodes each attached to a subject and detecting EEG data; generating a user... The General Hospital Corporation

08/17/17 / #20170231556

Systems and methods for predicting arousal to consciousness during general anesthesia and sedation

A system and method for monitoring a patient suspected of experiencing a state of unconsciousness are provided. In certain aspects, the method includes assembling physiological data, obtained from a plurality of sensors placed on a subject, into sets of time-series data, separating, from the sets of time-series data, a plurality... The General Hospital Corporation

08/17/17 / #20170233365

Cyclooctenes for bioorthogonol reactions

This disclosure relates to trans-cyclooctene compounds and methods of using the same in bioorthogonal labeling experiments.... The General Hospital Corporation

08/17/17 / #20170233464

Use of tgf-beta antagonists to treat infants at risk of developing bronchopulmonary dysplasia

The disclosure relates to methods of treating an infant at risk of developing bronchopulmonary dysplasia, including premature infants, by administering a TGF-β antagonist during the perinatal period, including the prenatal period and/or the postnatal period. For administration during the prenatal period, the TGF-β antagonist can be administered either directly to... The General Hospital Corporation

08/17/17 / #20170233730

Regulation of mir-33 micrornas in the treatment of cholesterol-related disorders

Compositions comprising nucleic acid sequences that target MiR-33 microRNAs are described, together with uses of the same in the treatment of cholesterol-related disorders.... The General Hospital Corporation

08/17/17 / #20170234951

Systems and methods for improved reconstruction of magnetic resonance fingerprinting data with low-rank methods

Systems and methods for reconstructing MR parameter maps of a subject from magnetic resonance fingerprinting (MRF) data acquired using a magnetic resonance imaging (MRI) system. The method includes providing MRF data acquired from a subject using an MRI system and reconstructing the MRF data by solving a constrained optimization problem... The General Hospital Corporation

08/17/17 / #20170235917

Systems and methods for monitoring and controlling a cardiovascular state of a subject

Systems and methods for monitoring and/or controlling a cardiovascular system of a subject are disclosed. In some aspects, the method includes acquiring cardiovascular data from a subject, analyzing the cardiovascular data to determine a time trajectory for at least one cardiovascular parameter, and determining, using the time trajectory, a likelihood... The General Hospital Corporation








ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009



###

This listing is an abstract for educational and research purposes is only meant as a recent sample of applications filed, not a comprehensive history. Freshpatents.com is not affiliated or associated with The General Hospital Corporation in any way and there may be associated servicemarks. This data is also published to the public by the USPTO and available for free on their website. Note that there may be alternative spellings for The General Hospital Corporation with additional patents listed. Browse our Agent directory for other possible listings. Page by FreshPatents.com

###