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The General Hospital Corporation
The General Hospital Corporation D b a Massachusetts General Hospital
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The General Hospital Corporation D b a Massachusettes General Hospital
The General Hospital Corporation D b a Massachusets General Hospital
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The General Hospital Corporation Inc
The General Hospital Corporation D b a Massachuseets General Hospital
The General Hospital Corporation D b a Massachuset
The General Hospital Corporation D b a Massachuset General Hospital
The General Hospital Corporation D b a Massachuset Ts General Hospital
The General Hospital Corporation D b a Massachusettls General Hospital
The General Hospital Corporation Dba Massachusetts Ceneral Hospital
The General Hospital Corporation D b a Massachussetts General Hospital
The General Hospital Corporation D b a Massachusetts Gerneral Hospital
The General Hospital Corporation_20100121

The General Hospital Corporation patents


Recent patent applications related to The General Hospital Corporation. The General Hospital Corporation is listed as an Agent/Assignee. Note: The General Hospital Corporation may have other listings under different names/spellings. We're not affiliated with The General Hospital Corporation, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "T" | The General Hospital Corporation-related inventors


 new patent  System and non-invasively monitoring intracranial pressure

A system and method for non-invasively monitoring intracranial pressure are provided. In some aspects, the method comprises acquiring diffuse correlation spectroscopy data at a temporal resolution greater than a pulsatile frequency of cerebral blood flow of a subject using one or more optical sensors placed about a subject, and determining... The General Hospital Corporation

 new patent  Method and dermatological treatment and tissue reshaping

The present invention provides improved methods and apparatus for skin treatment and tissue remodeling. The apparatus includes an array of needles that penetrate the skin and serve as electrodes to deliver radio frequency current or other electrical or optical energy into the tissue being treated, causing thermal damage in controlled... The General Hospital Corporation

Anesthetic compounds and related methods of use

Provided herein is also a pharmaceutical composition comprising a compound according to formula (I) and a pharmaceutically acceptable carrier, and a method for providing anesthesia in a subject by administering such a pharmaceutical composition.... The General Hospital Corporation

Antifugetactic agents for the treatment of cancers

This invention provides methods and compositions for modulating movement of eukaryotic cells with migratory capacity. More specifically, the invention provides anti-fugetactic agents and methods for the use thereof in enhancing an immune response.... The General Hospital Corporation

Antifugetactic agents for the treatment of cancers

This invention provides methods and compositions for modulating movement of eukaryotic cells with migratory capacity. More specifically, the invention provides anti-fugetactic agents and methods for the use thereof in enhancing an immune response.... The General Hospital Corporation

Antifugetactic agents for the treatment of cancers

This invention provides methods and compositions for modulating movement of eukaryotic cells with migratory capacity. More specifically, the invention provides antifugetactic agents and methods for the use thereof in enhancing an immune response.... The General Hospital Corporation

Anti-fugetactic agents for the treatment of cancers

This invention provides methods and compositions for modulating movement of eukaryotic cells with migratory capacity. More specifically, the invention provides anti-fugetactic agents and methods for the use thereof in enhancing an immune response.... The General Hospital Corporation

Compositions and methods for enhancing bioenergetic status in female germ cells

Compositions and methods comprising bioenergetic agents for restoring the quality of aged oocytes, enhancing oogonial stem cells or improving derivatives thereof (e.g., cytoplasm or isolated mitochondria) for use in fertility-enhancing procedures, are described.... The General Hospital Corporation

Tumor and microenvironment gene expression, compositions of matter and methods of use thereof

This invention relates generally to compositions and methods for identifying genes and gene networks that respond to, modulate, control or otherwise influence tumors and tissues, including cells and cell types of the tumors and tissues, and malignant, microenvironmental, or immunologic states of the tumor cells and tissues. The invention also... The General Hospital Corporation

Systems and methods for slice dithered enhanced resolution simultaneous multislice magnetic resonance imaging

Systems and methods for simultaneously acquiring high-resolution images of a subject from multiple different slice locations using magnetic resonance imaging (“MRI”) are described. The present invention overcomes the aforementioned drawbacks by providing method for producing a plurality of images of a subject with a magnetic resonance imaging (“MRI”) system. A... The General Hospital Corporation

Methods for the cryopreservation of mammalian cells

Manufactured capillary tubes can include: a tubular member; and a coating applied partially covering the tubular member, the coating defining a window where the tubular member is free of the coating. Kits containing and methods related to the capillary tubes can be used for the cryopreservation of cells.... The General Hospital Corporation

Photoactivatable antimicrobial agents and therapeutic and diagnostic methods of using same

The present invention provides photosensitizer compounds for use in detecting beta-lactamase activity. Methods and kits that utilize the photosensitizer compounds of the invention for the detection of, quantitation of, and classification or typing of microbial beta-lactamases.... The General Hospital Corporation

System and magnetic resonance angiography using hyperpolarized fluid

Systems and methods are provided for performing a medical imaging. The system includes a main magnet system configured to generate a main static magnetic field about at least a region of interest (ROD of a subject arranged in the main magnet system. The system also includes at least one gradient... The General Hospital Corporation

Agents and methods for treating pancreatic ductal adenocarcinomas

It has been discovered that NAD+-dependent histone deacetylase SIRT6 is critical for suppression of PDAC by con trolling the expression of Lin28b, which is a negative regulator of let-7 microRNA. Specifically, SIRT6 loss results in histone hyperacetylation at the Lin28b promoter, Myc recruitment, and pronounced induction of Lin28b and downstream... The General Hospital Corporation

Genomewide unbiased identification of dsbs evaluated by sequencing (guide-seq)

Unbiased, genomewide and highly sensitive methods for detecting mutations, e.g., off-target mutations, induced by engineered nucleases.... The General Hospital Corporation

Method and system for integrated mutliplexed photometry module

Reusable network of spatially-multiplexed microfluidic channels each including an inlet, an outlet, and a cuvette in-between. Individual channels may operationally share a main or common output channel defining the network output and optionally leading to a disposable storage volume. Alternatively, multiple channels are structured to individually lead to the storage... The General Hospital Corporation

Systems and methods for time-resolved diffuse correlation spectroscopy

The present disclosure generally relates to improvements to systems and methods for measuring the dynamic properties of scattering particles within a medium, including fluid flow. Specifically, the present disclosure relates to systems and methods for time-resolved diffuse correlation spectroscopy. This disclosure provides systems and methods for determining dynamics in a... The General Hospital Corporation

System and monitoring absolute blood flow

A system and method for non-invasively estimating an absolute blood flow of a vascular region in a subject using optical data are provided. In some aspects, the method includes acquiring optical data from the vascular region using one or more optical sensors placed about the subject, and determining, using the... The General Hospital Corporation

Apparatus, method and computer-accessible medium for obtaining tissue sample

Apparatus and method can be provided for obtaining at least one anatomical sample. For example, it is possible to provide and insert a housing into a body or provided on a hydrated anatomical structure. Further, with a source, it is possible to emit an electromagnetic radiation which causes at least... The General Hospital Corporation

Methods and compositions for treating degenerative and ischemic disorders

Model systems have shown that shifting a cell's reliance from oxidative phosphorylation (OXPHOS) to glycolysis can protect against cell death. Exploiting the therapeutic potential of this strategy, however, has been limited by the lack of clinically safe agents that remodel energy metabolism. The present invention identifies non-toxic small molecules (e.g.,... The General Hospital Corporation

Hemojuvelin fusion proteins and uses thereof

The present invention provides a hemojuvelin (HJV) fusion protein (e.g., a human HJV.Fc) protein, polynucleotides and vectors encoding such proteins, and methods for making such proteins. Also provided are methods for treating iron-related disorders which include administration of a HJV fusion protein to a patient in need thereof... The General Hospital Corporation

Anti-cspg4 reagents and methods of treating cancer

Embodiments of the present invention provide antibodies, antigen binding portions thereof, and other polypeptides (e.g., CARs), that specifically bind to CSPG4, an antigen expressed on cancer cells. Monoclonal antibodies, antibody-drug conjugates, and/or CAR-T-cells that specifically bind to CSPG4 positive cancer cells are also provided.... The General Hospital Corporation

Eluting matrix and uses thereof

CXCL12 polypeptide eluting matrices encapsulating at least one cell are described for use in the treatment of autoimmune disorders.... The General Hospital Corporation

Novel compositions and uses of metformin agents

Methods and compositions for improving the delivery and/or efficacy of a therapy (e.g., an anti-cancer, anti-fibrotic or anti-inflammatory therapy) are disclosed. The invention is based, at least in part, on the discovery that metformin, a widely prescribed anti-diabetic drug, can affect the tumor microenvironment (e.g., directly, i.e., independent of its... The General Hospital Corporation

Plasmonic nanoparticle immunoassay method

A method for detecting a target cell surface molecule and classifying cell types in a fluid sample. The method involves the addition of a reagent to the fluid sample. The reagent includes nanoparticles with optical plasmonic resonances, and at least one fluorescent probe. The nanoparticles are a bio-optical probe for... The General Hospital Corporation

Therapeutic nanoparticles and methods of use thereof

Provided herein are therapeutic nanoparticles having a diameter of between 10 nm to 30 nm, and containing a polymer coating, and a nucleic acid containing a sequence complementary to a sequence within a micro-RNA identified as having a role in cancer cell metastasis or anti-apoptotic activity in a cancer cell... The General Hospital Corporation

Compositions and methods of identifying tumor specific neoantigens

The present invention related to immunotherapeutic peptides and their use in immunotherapy, in particular the immunotherapy of cancer. Specifically, the invention provides a method of identifying tumor specific neoantigens that alone or in combination with other tumor-associated peptides serve as active pharmaceutical ingredients of vaccine compositions which stimulate anti-tumor responses.... The General Hospital Corporation

Atherosclerosis imaging agents and methods of using the same

Methods for detecting the presence of atherosclerotic structures in order to diagnose or prevent atherosclerosis are provided herein. In particular, it has been found that methylene blue injected intravenously acts as an excellent indicator because the compound targets high-risk plaque, atheroma, macrophages, and other atherosclerotic structures formed within the endothelial... The General Hospital Corporation

Synthetic transcriptional and epigenetic regulators based on engineered, orthogonal zinc finger proteins

Embodiments disclosed herein provide artificial expression systems comprising the zinc-finger containing transcription factors and engineered promoters to modulate expression of genes of interest. Engineered zinc-finger transcription factors that interact with engineered promoters constitute synthetic and regulatable expression systems which facilitate the modulation of gene expression as desired.... The General Hospital Corporation

Digital analysis of circulating tumor cells in blood samples

This disclosure relates to new assay methods for analysis of circulating tumor cells (CTCs) in blood samples for detection, e.g., early detection, and/or monitoring of disease, e.g., cancer. The methods provide ultra-high sensitivity and specificity, and include the use of microfluidic isolation of CTCs and digital detection of RNA derived... The General Hospital Corporation

Compositions and methods for treating allergic inflammation

Compositions and methods are provided that relate to inhibiting and/or reducing glycosylation of IgE for the treatment of allergic and atopic disorders. These compositions and methods are based, in part, on the discovery that glycosylation of IgE is a requirement for initiation of the allergic cascade and that a single... The General Hospital Corporation

Prostate cancer survival and recurrence

The disclosure includes the identification and use of gene expression profiles, or patterns, with clinical relevance to prostate cancer. In particular, the disclosure is based on the identities of genes that are correlated with patient survival and prostate cancer recurrence. The gene expression profiles may be embodied in nucleic acid... The General Hospital Corporation

Compositions for regulating iron homeostasis and methods of using same

The present invention relates to hemojuvelin-IgG Fc domain fusion proteins, variants, derivatives, fragments and peptide mimetics derived therefrom and methods of using these fusion proteins for the regulation of iron homeostasis and the treatment of diseases related to iron homeostasis.... The General Hospital Corporation

Apparatus and fixation to endoscope accessories

A probe coupling apparatus can be provided which can include, e.g., at least two opposing edges, one of the edges being configured to receive a tip of a probe. The exemplary apparatus can also include an orifice provided between the edges and a portion provided between the opposing edges and... The General Hospital Corporation

02/08/18 / #20180036029

Method and tissue grafting

Exemplary embodiments of apparatus and method for harvesting small portions of tissue (“micrografts”) to form grafts can be provided. For example, a hollow tube can be inserted into tissue at a donor site, where a distal end of the hollow tube can have two or more points or extensions to... The General Hospital Corporation

02/08/18 / #20180036552

System and photo-dynamic procedure

A problem of incomplete inhibition of harmful cells/bacteria and short duration of time, after the photodynamic treatment, during which such cells may re-grow, is solved by exposing the target bacteria with a multi-component photosensitizer material formed by adding a predetermined potentiating chemical to a conventional single-component photosensitizer at the target,... The General Hospital Corporation

02/08/18 / #20180039328

Biomedical system variably configured based on estimation of information content of input signals

Computationally efficient procedure for estimating modulation depth from multivariate data. Neural interface system utilizing such procedure to rank neural signals and select optimal channel subset for inclusion in the neural decoding algorithm. The proposed system offers several orders of magnitude lower complexity and data-processing time but virtually identical decoding performance... The General Hospital Corporation

02/01/18 / #20180028253

Method and dermatological hypopigmentation

Exemplary embodiments of the present disclosure provide method and apparatus for effecting (e.g., lightening) an appearance of skin by cooling or freezing small separated surface regions of the skin to produce regions of local hypopigmentation. The width of the regions can be, for example, smaller than about 1 mm or... The General Hospital Corporation

02/01/18 / #20180028659

Compositions and methods comprising energy absorbing materials for follicular delivery

The present invention provides compositions comprising energy (e.g., light) absorbing submicron particles (e.g., nanoparticles comprising a silica core and a gold shell) and methods for delivering such particles via topical application. This delivery is facilitated by application of mechanical agitation (e.g. massage), acoustic vibration in the range of 10 Hz-20... The General Hospital Corporation

02/01/18 / #20180030425

Variants of crispr from prevotella and francisella 1 (cpf1)

Engineered CRISPR from Prevotella and Francisella 1 (Cpf1) nucleases with altered and improved target specificity and their use in genomic engineering, epigenomic engineering, genome targeting, genome editing, and in vitro diagnostics.... The General Hospital Corporation

02/01/18 / #20180031667

System and magnetic resonance fingerprinting in the presence of inhomogeneous magnetic fields

Systems and methods for magnetic resonance fingerprinting (“MRF”) using highly differentiated trajectories that optimize differentiation between magnetic resonance signal patterns as a function of relaxation time(s) and static magnetic field homogeneity are described. Using the optimized acquisition parameters, MRF can be performed in the presence of inhomogeneous magnetic fields. Flip... The General Hospital Corporation

01/25/18 / #20180021087

Method and tissue expansion

Exemplary embodiments of the present disclosure provide method and apparatus for facilitating stretching of a biological tissue by forming a plurality of micro-slits in the tissue. Each micro-slit can be less than about 2 mm or less than about 1.5 mm long, or even less than about 1 mm, such... The General Hospital Corporation

01/25/18 / #20180023133

Systems and methods for epigenetic sequencing

The present invention generally relates to microfluidics and/or epigenetic sequencing. In one set of embodiments, cells contained within a plurality of microfluidic droplets are lysed and the DNA (e.g., from nucleosomes) within the droplets are labeled, e.g., with adapters containing an identification sequence. The adapters may also contain other sequences,... The General Hospital Corporation

01/25/18 / #20180023142

Micrornas in neurodegenerative disorders

Provided herein are methods of treating a neurodegenerative disorder such as Amyotrophic Lateral Sclerosis (ALS) or Multiple Sclerosis (MS) that include administering to a subject at least one inhibitory nucleic acid that decreases the level or activity of microRNA has-miR-155.... The General Hospital Corporation

01/18/18 / #20180015186

Compositions and methods for in vivo imaging

This document relates to compounds useful for targeting PARP1. Also provided herein are methods for using such compounds to detect and image cancer cells.... The General Hospital Corporation

01/18/18 / #20180017778

Spectrally encoded probe with multiple diffraction orders

A spectrally encoded endoscopic probe. The probe has a light guiding component, a light focusing component, and a grating component. The probe is configured such that a set of light beams of multiple wavelengths are diffracted by the grating component in different orders at substantially the same angle. The set... The General Hospital Corporation

01/11/18 / #20180008500

Method and dermatological treatment

Exemplary methods and systems can be provided for resurfacing of skin that include formation of a plurality of small holes, e.g., having widths greater than about 0.2 mm and less than about 0.7 mm or 0.5 mm, using a mechanical apparatus. Compressive and/or tensile forces can then be applied to... The General Hospital Corporation

01/11/18 / #20180008823

System and stimulating hair growth

A system and method are provided for stimulating hair growth of a user. The system includes a stimulating unit in communication with a control unit. The stimulating unit includes at least one electrode to be placed on a region of the user, a pulser configured to send electronic pulses to... The General Hospital Corporation

01/11/18 / #20180010965

Spectrally-encoded endoscopy techniques, apparatus and methods

Exemplary apparatus for method for forming at least one spectral encoding endoscopy configuration. For example, it is possible to modify a spacer configuration and an lens optics configuration to have respective predetermined lengths, and also to modify a dispersive optics configuration to have a further predetermined length. Further, the modified... The General Hospital Corporation

01/11/18 / #20180012515

Medical simulation apparatus

Systems and methods for simulating medical procedures are provided. In one example, systems and methods are provided for a neck simulator that presents realistic interactions with the neck during medical procedures, including injections, such as may be performed during a laryngeal injection.... The General Hospital Corporation

01/04/18 / #20180000886

Prevention and treatment of itch with an mrgpr antagonist

Embodiments described herein relates to compositions and methods of preventing and/or treating itch in a subject using a therapeutically effective amount of a MRG receptor antagonist. e.g., a tripeptide QWF. In one embodiment, the itch is a non-histamine mediated itch.... The General Hospital Corporation

01/04/18 / #20180000913

Methods for profiling the t cell repertoire

The present disclosure relates to methods for profiling subject specific and personalized T cell receptor (TCR) repertoires using a single-cell sequencing method. More particularly, disclosed are methods for determining binding of T cell receptors to subject specific neoantigens. In addition, the techniques herein may identify the antigenic targets of T... The General Hospital Corporation

01/04/18 / #20180002398

Methods, arrangements and systems for obtaining information associated with an anatomical sample using optical microscopy

Arrangements and methods are provided for obtaining information associated with an anatomical sample. For example, at least one first electro-magnetic radiation can be provided to the anatomical sample so as to generate at least one acoustic wave in the anatomical sample. At least one second electro-magnetic radiation can be produced... The General Hospital Corporation

01/04/18 / #20180002681
01/04/18 / #20180003481

Devices, systems, methods and storage mediums using full range optical coherence tomography

One or more devices, systems, methods and storage mediums for performing continuously, full range optical coherence tomography (OCT) without losing A-lines are provided. Examples of such applications include imaging, evaluating and diagnosing biological objects, such as, but not limited to, for cardio and/or ophthalmic applications, and being obtained via one... The General Hospital Corporation

12/28/17 / #20170367581

Systems, methods and computer-accessible medium which provide microscopic images of at least one anatomical structure at a particular resolution

Exemplary embodiments of systems and methods can be provided which can generate data associated with at least one portion of a sample. For example, at least one first radiation can be forwarded to the portion through at least one optical arrangement. At least one second radiation can be received from... The General Hospital Corporation

12/28/17 / #20170368202

Optical sensor conjugates for detecting reactive oxygen and/or reactive nitrogen species in vivo

The present invention provides methods and compositions based on optical sensor conjugates that are useful for detecting reactive oxygen, reactive nitrogen, or both species that are a direct result of inflammation caused by tissue damage.... The General Hospital Corporation

12/28/17 / #20170369839

Isolated human lung progenitor cells and uses thereof

Provided herein are methods and compositions relating, in part, to the generation of human progenitor cells committed to the lung lineage and uses of such cells for treatment of lung diseases/disorders or injury to the lung. Whether an adult stem cell can be isolated from human adult lung remains controversial... The General Hospital Corporation

12/28/17 / #20170369939

Rapid quantitative detection of single nucleotide polymorphisms or somatic variants and methods to identify malignant neoplasms

Provided are systems, kits, and methods for the quantitative detection of single nucleotide polymorphisms or variants to identify malignant neoplasms. The methods include use of modified oligonucleotide blockers with peptide nucleic acid backbones that hybridize to and block logarithmic amplification of the wild-type alleles of a target, and incorporation of... The General Hospital Corporation

12/21/17 / #20170360967

Collagen targeted imaging probes

Disclosed herein are collagen-targeted imaging agents for positron emission tomography and related imaging methods using the collagen-targeted imaging agents. The collagen-targeted imaging agent is a cyclic polypeptide comprising a cyclic main body, wherein the cyclic main body comprises at least one S—S bond; at least two branches, wherein each of... The General Hospital Corporation

12/21/17 / #20170362266

Metabolic labeling and molecular enhancement of biological materials using bioorthogonal reactions

The present application provides methods of functionalizing an organ or tissue of a mammal by administering a nutrient (e.g., peracetylated N-azido galactosamine Ac4GalNAz) to the mammal or by culturing an organ or tissue in a bioreactor containing such nutrient. The present application also provides methods of selectively functionalizing extracellular matrix... The General Hospital Corporation

12/21/17 / #20170362311

Methods and compositions for regulating iron homeostasis by modulation of bmp-6

Modulation of iron homeostasis by regulating BMP-6 activity is provided. Methods of using BMP-6 and BMP-6 protein-specific reagents, such as antibodies, for altering serum iron levels in humans are provided. Such antibodies are useful in pharmaceutical compositions for the prevention and treatment of hemochromatosis and anemia of inflammation.... The General Hospital Corporation

12/14/17 / #20170354317

Spectrally encoded endoscopic probe having a fixed fiber

Exemplary apparatus, systems, methods of making, and methods of using a configuration in an optical arrangement for spectrally encoded endoscopy (SEE) probe can be provided. For example, the probe can comprise a fixed guiding portion and a rotatable dispersive portion.... The General Hospital Corporation

12/14/17 / #20170356054

Biomarkers of cancer

Methods for diagnosing cancer based on detecting the presence of increased levels of expression of satellite repeats and/or Line-1.... The General Hospital Corporation

Patent Packs
12/07/17 / #20170348437

Compounds, systems, and methods for monitoring and treating a surface of a subject

Compounds, systems, and methods are provided for the design and assembly of a non-invasive, analyte sensing dressing. The dressing can be therapeutic. The dressing includes a sensor and a matrix. The sensor is capable of detecting analytes such as molecular oxygen, carbon dioxide, nitric oxides, dissolved analytes in plasma, and... The General Hospital Corporation

12/07/17 / #20170349540

Histone deacetylase inhibitors

Provided herein are brain penetrant histone deacetylase (HDAC) inhibitors useful for treating diseases or disorders associated with HDAC. An exemplary HDAC inhibitor provided herein exhibits a brain-to-plasma ratio of 20:1. Pharmaceutical compositions comprising HDAC inhibitors and methods for treating diseases associated with HDAC are also provided.... The General Hospital Corporation

12/07/17 / #20170350896

Diagnosis and monitoring treatement of prostate cancer

Provided herein are assays and methods related to determining a ratio of expression levels of PSA/PSMA or determining the expression level of PSMA in circulating tumor cells for diagnosis and/or for the purpose of monitoring treatment efficacy for prostate cancers that are likely hormone resistant.... The General Hospital Corporation

11/30/17 / #20170340736

Photoactivatable caged tamoxifen and tamoxifen derivative molecules and methods of use thereof

Provided herein are compositions containing photoactivatable caged tamoxifen and tamoxifen derivative molecules. Also provided are kits containing one of these compositions and a light source. Also provided are methods of optically inducing nuclear translocation of a fusion protein containing a mammalian estrogen receptor ligand binding domain in a eukaryotic cell... The General Hospital Corporation

11/30/17 / #20170342151

Anti-chondroitin sulfate proteoglycan 4 antibodies and uses thereof

Described herein are antibodies that bind chondroitin sulfate proteoglycan 4 (CSPG4) and, in particular, chimeric and humanized anti-CSPG4 antibodies and fragments thereof. Also provided herein are methods of using individual humanized antibodies or compositions thereof for the detection, prevention, and/or therapeutic treatment of CSPG4-related diseases, in particular, melanoma.... The General Hospital Corporation

11/30/17 / #20170342398

Microfluidic droplet encapsulation

Microfluidic devices and methods for the encapsulation of particles within liquid droplets are disclosed. The new methods and devices form 1-100 picoliter-size monodisperse droplets containing the particles, such as single cells, encapsulated in individual liquid droplets. The particles can be encapsulated in droplets of a fluid by passing a fluid... The General Hospital Corporation

11/30/17 / #20170343539

Nucleic acid constructs and methods for labeling and detecting nucleosomal dna modifications

Embodiments disclosed herein provide methods for identifying cell-type-specific nucleosomal DNA modifications. The methods leverage nucleosomal DNA barcoding and pool-and-split multiplexing to provide high-throughout, quantitative profiling of nucleosomal DNA states. The methods enable the profiling of multiple nucleosomal DNA marks across different cell types and/or conditions thereby linking quantitative changes in... The General Hospital Corporation

11/23/17 / #20170332933

Deep brain source imaging with m/eeg and anatomical mri

A method for non-invasively resolving electrophysiological activity in sub-cortical structures located deep in the brain by comparing amplitude-insensitive M/EEG field patterns arising from activity in subcortical and cortical sources under physiologically relevant sparse constraints is disclosed. The method includes a sparse inverse solution for M/EEG subcortical source modeling. Specifically, the... The General Hospital Corporation

11/23/17 / #20170333540

Compositions and methods for the prevention and treatment of autoimmune conditions

The methods include selectively reducing or expanding T cells according to the antigenic specificity of the T cells. Therefore, the present invention can be used to reduce or eliminate pathogenic T cells that recognize autoantigens, such as beta cell specific T cells. As such, the present invention can be used... The General Hospital Corporation

11/23/17 / #20170334804

F-18 labeled tracer and methods of manufacture

A method of producing a radiofluorinated compound comprising the steps of forming a reaction mixture comprising a reactant having a formula of R—Y and a radiofluorinating agent having a formula of R′—18F; and contacting the reaction mixture with microwave radiation to achieve a temperature of between 100° C. and 250°... The General Hospital Corporation

11/23/17 / #20170334842

Inhibitors of the mitf molecular pathway

as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful as MITF inhibitors, MITF pathway inhibitors and for the treatment of cancer.... The General Hospital Corporation

11/23/17 / #20170335317

Methods for modulating atrx-dependent gene repression

Methods and compositions for modulation of the activity of alpha thalassemia/mental retardation syndrome X-linked (ATRX), e.g., modulation of DNA-ATRX or RNA-ATRX interactions, and methods for identifying and using compounds that modulate DNA-ATRX or RNA-ATRX interactions, as well as the compounds themselves.... The General Hospital Corporation

11/23/17 / #20170335324

Methods for treating neurodegenerative diseases

Methods for treating, and for identifying novel treatments for, neurodegenerative diseases, as well as animal and cellular models. The present disclosure shows that age dependent accumulation of genomic lesions leads to the production of RNA molecules within neurons that mimic viruses and intrinsically activate innate immune signaling, which triggers neurodegeneration.... The General Hospital Corporation

11/23/17 / #20170336395

Methods and compositions for treating amyloid deposits

The present disclosure provides methods of determining A-beta in a mammal before and after treatment of an amyloid disorder, comprising obtaining a first blood sample from the mammal; administering to the mammal a treatment for an amyloid disorder; obtaining a second blood sample from the mammal; quantifying a level of... The General Hospital Corporation

11/16/17 / #20170326171

Advanced functional biocompatible polymer putty used as a hemostatic agent for treating damaged tissue and cells

A hemostatic putty for treatment of a variety of wounds topographies, including but not limited to highly three dimensional wounds, for example gunshot wounds and impalements, is disclosed. The putty is comprised of a matrix polymer weakly crosslinked or not crosslinked such that a viscoelastic matrix is formed. The viscoelastic... The General Hospital Corporation

Patent Packs
11/16/17 / #20170326244

Biotin complexes for treatment and diagnosis of alzheimer's disease

Described herein are compositions and methods for treating or imaging Alzheimer's disease (AD). The compositions comprise a biotin moiety and a siRNA moiety, without the need for a targeting agent such as an antibody, avidin, or streptavidin. In certain embodiments, the compositions further comprise a diagnostic agent.... The General Hospital Corporation

11/16/17 / #20170326273

Human airway stem cells in lung epithelial engineering

Methods of using human airway stem cells in lung epithelial engineering, optionally wherein the cells are contacted with a gamma secretase inhibitor, bioartificial airway organs produced thereby, and the use thereof, e.g., for transplantation. Also methods of treating a bio-artificial matrix with Tenascin-C and/or fibrillin 2.... The General Hospital Corporation

11/16/17 / #20170326293

Syringe infusion pump

An infusion apparatus for use with a syringe includes a housing enclosing a drivetrain. The drivetrain includes a pinion, spur gears, and a worm gear. One spur gear is arranged to engage with the pinion and another spur gear is arranged to engage with the worm gear. The housing also... The General Hospital Corporation

11/16/17 / #20170327804
11/16/17 / #20170327805

Using rna-guided foki nucleases (rfns) to increase specificity for rna-guided genome editing

Methods for increasing specificity of RNA-guided genome editing, e.g., editing using CRISPR/Cas9 systems.... The General Hospital Corporation

11/16/17 / #20170327806

Engineered crispr-cas9 nucleases with altered pam specificity

Engineered CRISPR-Cas9 nucleases with altered and improved PAM specificities and their use in genomic engineering, epigenomic engineering, and genome targeting.... The General Hospital Corporation

11/16/17 / #20170327823

Selective reactivation of genes on the inactive x chromosome

Methods and compositions for selectively reactivating genes on the inactive X chromosome (Xi) in a locus-specific manner, e.g., genes associated with X-linked diseases, e.g., Rett Syndrome, Factor VIII or IX deficiency, Fragile X Syndrome, Duchenne muscular dystrophy, and PNH, in heterozygous females.... The General Hospital Corporation

11/16/17 / #20170328971

Method for simultaneous time-interleaved multislice magnetic resonance imaging

Methods for reducing scan time in magnetic resonance imaging (“MRI”), particularly when imaging three-dimensional image volumes, using a simultaneous time-interleaved multislice (“STIMS”) acquisition are described. The unused time in each repetition time (“TR”) period is exploited to provide an additional reduction in encoding time for a three-dimensional acquisition (e.g., a... The General Hospital Corporation

11/09/17 / #20170319071

System, utilizing optical dispersion for fourier-domain optical coherence tomography

An apparatus can be provided which can include a laser arrangement which can be configured to provide a laser radiation, and can include an optical cavity. The optical cavity can include a dispersive optical first arrangement which can be configured to receive and disperse at least one first electro-magnetic radiation... The General Hospital Corporation

11/09/17 / #20170319378

Treatment systems for removing heat from subcutaneous lipid-rich cells and treatment systems for affecting subcutaneous lipid-rich cells

The present invention relates to methods for use in the selective disruption of lipid-rich cells by controlled cooling. The present invention further relates to a device for use in carrying out the methods for selective disruption of lipid-rich cells by controlled cooling.... The General Hospital Corporation

11/09/17 / #20170319517

Methods, compositions, and kits for treating pain and pruritis

The invention features a method for inhibiting one or more voltage-gated ion channels in a cell by contacting the cell with (i) a first compound that activates a channel-forming receptor that is present on nociceptors and/or pruriceptors; and (ii) a second compound that inhibits one or more voltage-gated ion channels... The General Hospital Corporation

11/09/17 / #20170319676

Antifugetactic agents for the treatment of cancers

This invention provides methods and compositions for modulating movement of eukaryotic cells with migratory capacity. More specifically, the invention provides fugetactic agents and methods for the use thereof in enhancing an immune response.... The General Hospital Corporation

11/09/17 / #20170319776

System and guided removal from an in vivo subject

In accordance with some configurations, systems and methods for guided removal from an in vivo subject are provided. In some configurations, a method for removing an object is provided. The method comprising, guiding a flexible tube through a passageway of an in vivo subject, wherein the flexible tube comprises at... The General Hospital Corporation

11/09/17 / #20170322079

Simple monolithic optical element for forward-viewing spectrally encoded endoscopy

Exemplary spectrally encoded probes are provided having forward view capabilities. These probes are configured such that the detection element comprises a plurality of light collecting components, where the distal ends at least partially surround the illumination element and the proximal ends form a linear array that is optically connected to... The General Hospital Corporation

11/09/17 / #20170322279

Multi-shot echo planar imaging using reordered segments and rf excitation pulse phase and slice profiles matched across interleaves

Described here are systems and methods for producing images with a magnetic resonance imaging (“MRI”) system using a high-resolution, motion-robust, artifact-free segmented echo planar imaging (“EPI”) technique. In particular, a fast low angle excitation echo planar imaging technique (“FLEET”) using variable flip angle (“VFA”) radio frequency (“RF”) excitation pulses that... The General Hospital Corporation

11/02/17 / #20170312314

System for treating a sebaceous gland

One aspect of the invention provides a system of treating a sebaceous gland in human skin with light energy to reduce acne symptoms. The system includes: a composition comprising a metallic nanoparticle dispersed within a carrier; means to vibrate at least a portion of the skin surface to which the... The General Hospital Corporation

11/02/17 / #20170313765

Direct expression of antibodies

The present invention relates to methods exogenous nucleic acid molecules, such as RNA, that encode an antibody or antigen-binding fragment of an antibody, and optionally encode a cellular modulation factor and/or a potentiation factor. The cellular modulation factor is a factor that results in increased expression of the antibody and/or... The General Hospital Corporation

11/02/17 / #20170313767

Methods of diagnosis and treatment of tuberculosis and infection

Described herein are methods of treating, diagnosing, and/or prognosing a disease in a subject relating to detection of the glycosylation state of the antibodies present in the subject. In some embodiments, the disease can be an infection. In some embodiments, an antibody glycosylation state that is indicative of the presence... The General Hospital Corporation

11/02/17 / #20170314075

Use of microvesicles in diagnosis and prognosis of medical diseases and conditions

The presently disclosed subject matter is directed to methods of aiding diagnosis, prognosis, monitoring and evaluation of a disease or other medical condition in a subject by detecting a biomarker in microvesicles isolated from a biological sample from the subject.... The General Hospital Corporation

10/26/17 / #20170303941

System and guided removal from an in vivo subject

In accordance with some configurations, systems and methods for guided removal from an in vivo subject are provided. In some configurations, a method for removing an object is provided. The method comprising, guiding a flexible tube through an in vivo subject's ureter, wherein the flexible tube comprises at least a... The General Hospital Corporation

10/26/17 / #20170304245

Compounds for the treatment of obesity and methods of use thereof

Pentacyclic triterpene weight loss agents are provided herein. Also provided are pharmaceutical formulations containing a therapeutically effective amount of one or more of the weight loss agents, or pharmaceutically acceptable salts or prodrugs thereof, in combination with one or more pharmaceutically acceptable excipients. The pharmaceutical formulations can be administered to... The General Hospital Corporation

10/26/17 / #20170304400

Methods for preventing fibrosis using cxcr4 and/or cxcr7 binding agents

This disclosure is directed to methods of treating a subject with a fibrotic or fibroproliferative disease, comprising administering to the subject a composition comprising an effective amount of an anti-fibrosis agent, e.g., a CXCR4 and/or CXCR7 binding agent, such as CXCL12.... The General Hospital Corporation

10/26/17 / #20170305866

Histone deacetylase 6 selective inhibitors for the treatment of bone disease

This invention relates to methods for treating bone disease associated with osteoclast activation using HDAC6 selective inhibitors, e.g., small molecule inhibitors such as reverse amide compounds.... The General Hospital Corporation

10/26/17 / #20170307595

Methods and devices to study metabolism

Methods and devices to screen test compounds, e.g., study metabolism of test compounds, e.g., a pro-drug, by one cell, e.g., a hepatocyte, and the effect of metabolism of the test compound by the first cell on a second cell, e.g., a cancer cell, are described.... The General Hospital Corporation








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