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The Hospital For Sick Children
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The Hospital For Sick Children patents


Recent patent applications related to The Hospital For Sick Children. The Hospital For Sick Children is listed as an Agent/Assignee. Note: The Hospital For Sick Children may have other listings under different names/spellings. We're not affiliated with The Hospital For Sick Children, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "T" | The Hospital For Sick Children-related inventors


 new patent  Method for diagnosing an inflammatory disorder

A method of diagnosing Kawasaki disease in a mammal is provided. The method comprises determining in a biological sample obtained from the mammal the expression level of at least IL-1RA, and optionally the level of one or more of, IL-Iβ, IL-18 and IL-18 BP, and diagnosing Kawasaki disease when the... The Hospital For Sick Children

Delivery of structurally diverse polypeptide cargo into mammalian cells by a bacterial toxin

There is a need for delivery platforms with robust capacity that offer the possibility to deliver diverse protein-based therapeutics into specific cells. Described herein is a platform for delivering cargo polypeptides into cells, which is based on a recombinant molecule comprising: a cargo polypeptide, a diphtheria toxin enzymatic fragment (DTA),... The Hospital For Sick Children

Simulator for practicing trans-oral surgery and use thereof

Simulators for practicing trans-oral surgery and methods of use thereof, are described. The simulator may include a simulated soft palate musculature adjacent to the simulated hard palate, and a simulated mucosal layer covering at least a portion of the simulated hard palate and at least a portion of the simulated... The Hospital For Sick Children

Alveolar-like macrophages and generating same

Alveolar-like macrophages and a method for generating alveolar-like macrophages from hemangioblasts is provided. The method comprises the steps of: i) culturing the hemangioblasts in a hematopoietic-inducing medium comprising vascular endothelial growth factor (VEGF), stem cell factor (SCF) and interleukin-3 (IL-3) for a sufficient period of time to generate macrophages, and... The Hospital For Sick Children

Modulation of dopamine receptor to promote neural cell differentiation

A method of promoting neural stem cell differentiation is provided comprising exposing neural stem cells to a dopamine D4 receptor antagonist.... The Hospital For Sick Children

Method for treating a brain tumour

A method of treating a brain tumour such as glioblastoma in a mammal is provided comprising administering to the mammal a DRD4 antagonist.... The Hospital For Sick Children

Dna methylation markers for neurodevelopmental syndromes

The present disclosure provides epigenetic signatures, comprising genomic CpG dinucleotide sequences, genes, and/or genomic regions, which are differentially methylated in individuals with CHARGE syndrome relative to non-CHARGE syndrome controls, and their use in methods and kits for detecting and/or screening for CHARGE syndrome, or the likelihood of CHARGE syndrome. The... The Hospital For Sick Children

Methods and uses related to rhabdoid tumors

Methods and uses for diagnosing and treating rhabdoid tumors such as Atypical Teratoid Rhabdoid Tumors are provided. In particular, the present disclosure provides methods of identifying and treating subgroups of rhabdoid tumors. In one embodiment, an inhibitor that targets Notch signaling or targets an epigenetic regulator selected from a BET... The Hospital For Sick Children

Methods and uses of slit for treating fibrosis

The present disclosure provides methods and uses of Slit protein and nucleic acid for inhibiting fibrosis and fibrotic-related disorders, for example, of the kidney, lung, heart, liver, or a wound. The Slit protein can be, for example, Slit2 or Slit2-N, or a Slit variant that can bind the Robo receptor... The Hospital For Sick Children

Compositions and methods for enhancing hair growth, promoting skin regeneration, and wound healing

The invention relates to compositions and methods useful for enhancing hair growth and promoting skin regeneration. Particularly, the invention provides topical compositions including trimebutine, salts, or active metabolites thereof, for enhancing or inducing hair growth and promoting skin regeneration. Compositions comprising trimebutine or a pharmaceutically acceptable salt or active metabolite... The Hospital For Sick Children

Methods of diagnosing and treating complications of pregnancy

Disclosed herein are methods for treating a pregnancy related hypertensive disorder, such as pre-eclampsia and eclampsia, using combinations of compounds that alter soluble endoglin, endothelial nitric oxide synthase, PGI2, TGF-β1, TGF-β3, activin A, BMP2, BMP7, and sFlt-1 expression levels or biological activity. Also disclosed are methods of diagnosing a pregnancy... The Hospital For Sick Children

Dna methylation markers for overgrowth syndromes

The present disclosure provides epigenetic signatures, comprising genomic CpG dinucleotide sequences, genes, and/or genomic regions, which are differentially methylated in individuals with Sotos syndrome relative to non-Sotos syndrome controls, and their use in methods and kits for detecting and/or screening for Sotos syndrome, or the likelihood of Sotos syndrome. The... The Hospital For Sick Children

Soluble bacterial and fungal proteins and methods and uses thereof in inhibiting and dispersing biofilm

The present disclosure relates to methods of treating or preventing a biofilm-related infection and methods of preventing and treating biofilm formation on indwelling medical devices, implants, and non-medical surfaces comprising administering at least one soluble microbial protein that is encoded by an exopolysaccharide biosynthetic operon or functional gene cluster, wherein... The Hospital For Sick Children

Mecp2e1 gene

The invention is a novel MECP2E1 splice variant and its corresponding polypeptide. The invention also includes methods of using these nucleic acid sequences and proteins in medical diagnosis and treatment of neuropsychiatric disorders or development disorders.... The Hospital For Sick Children

Mecp2e1 gene

The invention is a novel MECP2E1 splice variant and its corresponding polypeptide. The invention also includes methods of using these nucleic acid sequences and proteins in medical diagnosis and treatment of neuropsychiatric disorders or development disorders.... The Hospital For Sick Children

Treatment of peroxisome biogenesis disorder

A method is described for treating a peroxisome biogenesis disorder by administering to an individual in need thereof an effective amount of an autophagy inhibitor. Uses, compositions, and commercial packages are also described. The peroxisome biogenesis disorder may be Zellweger syndrome, neonatal adrenoleukodystrophy, Refsum disease, or cerebrohepatorenal syndrome. The autophagy... The Hospital For Sick Children

Erbb2 signaling and nerve regeneration

Use of an inhibitor of the ErbB2 receptor for treatment or repair of nerves and/or nerve tissues is provided. The inhibitor includes an antibody, in particular, a monoclonal antibody, for example, Herceptin. A medicament for treatment or repair of nerves and/or nerve tissues can be formulated which includes an inhibitor... The Hospital For Sick Children

Use of remote ischemic conditioning for traumatic injury

The invention provides methods for reducing traumatic injury through the use of ischemic conditioning.... The Hospital For Sick Children

Compositions and methods for treating or preventing clostridium infection

Clostridium difficile is a leading cause of antibiotic-associated infection in hospitals worldwide. There is a need for a vaccine to Clostridium difficile that can target toxic proteins, or that can elicit adequate immunity to prevent infection or reduce the severity of infection. Modified Clostridium difficile toxin A and B (TcdA... The Hospital For Sick Children

Plant-derived elastin binding protein ligands and methods of using the same

The present invention describes novel plant derived elastin-like peptides and peptidomimetics that may serve as functional ligands for elastin receptors and stimulate elastogenesis. The novel plant derived peptides provide an alternative (non-animal derived) source of GXXPG (SEQ ID NO. 2) containing peptides. The present invention also describes therapeutic compositions containing... The Hospital For Sick Children








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