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The J David Gladstone Institutes
The J David Gladstone Institutes A Testamentary Trust Established Under The Will Of J David Glads
The J David Gladstone Institutes A Testamentary Trust Established Under The Will Of J David Glad
The J David Gladstone Institutes A Testamentary Established Under The Will Of J David Glads

The J David Gladstone Institutes patents


Recent patent applications related to The J David Gladstone Institutes. The J David Gladstone Institutes is listed as an Agent/Assignee. Note: The J David Gladstone Institutes may have other listings under different names/spellings. We're not affiliated with The J David Gladstone Institutes, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "T" | The J David Gladstone Institutes-related inventors


Compositions and methods for reactivating latent immunodeficiency virus

The present disclosure provides compositions and methods for reactivating latent immunodeficiency virus and/or reducing transcription of HIV integrated into the genome of an HIV-infected cell. The present disclosure provides compositions and methods for treating an immunodeficiency virus infection.... The J David Gladstone Institutes

Methods for treating tauopathy

The present disclosure provides methods of reducing the level of acetylated Tau in a neuron or a glial cell in an individual, the methods involving administering to the individual a prodrug that is converted in the individual to salicylate. The present disclosure provides methods of treating a tauopathy in an... The J David Gladstone Institutes

Methods for treating a cytomegalovirus infection

The present disclosure provides a method for inhibiting cytomegalovirus (CMV) replication in a cell infected with CMV, the method comprising contacting the cell with a bisbenzimidazole compound. The present disclosure provides a method of treating a CMV infection in an individual, the method comprising administering to the individual an effective... The J David Gladstone Institutes

Compositions and methods for treating an immunodeficiency virus infection

The present disclosure provides an interfering, conditionally replicating human immunodeficiency virus (HIV) construct; infectious particles comprising the constructs; and compositions comprising the construct or the particle. The constructs, particles, and compositions are useful in methods of reducing HIV viral load in an individual, which methods are also provided.... The J David Gladstone Institutes

Compositions and methods for treating dengue virus infection

The present disclosure provides methods of treating a flavivirus infection, and compositions for use in the methods.... The J David Gladstone Institutes

Compositions and methods for regulating glucose metabolism

The present disclosure provides compositions for regulating glucose metabolism. The compositions provide for reduced levels of p75NTR and/or reduced binding of p75NTR to a GTPase such as Rab31 or Rab5. The compositions are useful in methods of regulating glucose metabolism, which methods are also provided.... The J David Gladstone Institutes

Inhibitors of jmjd2c as anticancer agents

The present disclosure provides compounds, pharmaceutical compositions and related methods for the treatment of cancer, e.g., castration-resistant prostate cancer (CRPC). Specifically, the present disclosure provides a series of 8-hydroxyquinoline derivatives which show cytotoxic effects on androgen-independent prostate cancer cells.... The J David Gladstone Institutes

In vitro assays for inhibition of microglial activation

The present invention provides cell-based assays, including high throughput cell-based assays, for identification of candidate therapeutic agent with no known agents with the ability to inhibit microglial activation in vivo in response to different ligands.... The J David Gladstone Institutes

 new patent  Methods for modulating genome editing

Provided herein are methods and kits for modulating genome editing of target DNA. The invention includes using small molecules that enhance or repress homology-directed repair (HDR) and/or nonhomologous end joining (NHEJ) repair of double-strand breaks in a target DNA sequence. Also provided herein are methods for preventing or treating a... The J David Gladstone Institutes

Reversible stencils for fabricating micro-tissues

The invention relates to devices, methods, kits, and compositions for in vitro generation of three-dimensional micro-tissues that are accurate models of heart, skeletal muscle, neuronal, and other tissues.... The J David Gladstone Institutes

Generating hepatocytes

Compositions and methods are described herein for inducing reprogramming of non-pluripotent cells across lineage and differentiation boundaries to generate endodermal progenitor cells and hepatocytes. Compositions and methods for expansion of endodermal progenitor cells without loss of phenotype are also described herein.... The J David Gladstone Institutes

Animal model of neuronal injury

The present invention provides non-human animal models of neuronal injury and/or cognitive dysfunction and methods of making and using such animal models. The animal models of the invention are particularly suited to assessing neurodegeneration in selected regions of interest in the CNS, and thus especially useful for testing the therapeutic... The J David Gladstone Institutes








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