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The Johns Hopkins University patents


Recent patent applications related to The Johns Hopkins University. The Johns Hopkins University is listed as an Agent/Assignee. Note: The Johns Hopkins University may have other listings under different names/spellings. We're not affiliated with The Johns Hopkins University, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "T" | The Johns Hopkins University-related inventors


 new patent  Anti-cancer dna vaccine employing plasmids encoding signal sequence, mutant oncoprotein antigen, and heat shock protein

Novel nucleic acid vectors comprising sequences encoding (a) an antigen, (b) a signal peptide, and (c) a heat shock protein, are disclosed, as are methods for using such vectors to induce antigen-specific immune responses and to treat tumors.. . ... The Johns Hopkins University

 new patent  Empowering additive manufacturing metals and alloys against localized three-dimensional corrosion

Functionalized metallic feedstock and three-dimensional articles formed therefrom via an additive manufacturing process are provided. The functionalized metallic feedstock includes a plurality of discrete metallic substrates including a first metallic substrate having a first surface area, in which at least a portion of the first surface area comprises a functionalizing agent selected to render the first metallic substrate resistant to corrosion.. ... The Johns Hopkins University

 new patent  Shape memory particles for biomedical uses

The presently disclosed subject matter provides compositions, methods, and kits comprising shape memory particles that can be used for delivering a drug and/or treating a disease or disorder in a patient. Specifically, shape changes in the presently disclosed shape memory particles can be used to control drug delivery spatially and/or temporally in a patient. ... The Johns Hopkins University

Superlattice structures for thermoelectric devices

Example superlattice structures and methods for thermoelectric devices are provided. An example structure may include a plurality of superlattice periods. ... The Johns Hopkins University

Biomimetic peptide and biodegradable delivery platform for the treatment of angiogenesis- and lymphangiogenesis-dependent diseases

Mimetic peptides having anti-angiogenic and anti-tumorigenic properties and methods of their use for treating cancer, ocular diseases, such as age-related macular degeneration, and other-angiogenesis-dependent diseases are disclosed. More particularly, an isolated peptide comprising the amino acid sequence lrrfstapfafidindvinf, which exhibits anti-angiogenic activity in endothelial cell proliferation, migration, adhesion, and tube formation assays, anti-migratory activity in human breast cancer cells in vitro, anti-angiogenic and anti-tumorigenic activity in vivo in breast cancer xenograft models, and age-related macular degeneration models is disclosed. ... The Johns Hopkins University

Nuclear imaging and radiotherapeutics agents targeting carbonic anhydrase ix and uses thereof

Highly potent and selective radionuclide-based imaging and therapy agents targeting carbonic anhydrase ix with minimum non-specific organ uptake are disclosed. Methods of imaging and/or treating carbonic anhydrase ix-expressing cells or tumors also are disclosed.. ... The Johns Hopkins University

Compositions and methods for implantation of processed adipose tissue and processed adipose tissue products

The invention provides compositions and methods for the preparation of processed adipose tissue. The invention further provides methods of use of the processed adipose tissue.. ... The Johns Hopkins University

Compositions and methods to accelerate resolution of acute lung inflammation

The present invention provides methods and compositions for treatment of acute inflammatory diseases or disorders and/or for treatment of lung injury. Certain exemplary methods involve administering an il-4 polypeptide or fragment thereof possessing cytokine activity or an il-4 agonist systemically to a subject having an inflammatory disease or disorder and/or a lung injury. ... The Johns Hopkins University

Methods and compositions for treating schizophrenia

The invention relates to methods and compositions for treating schizophrenia or bipolar disorder (in particular, mania) by using a combination of a synaptic vesicle protein 2a (sv2a) inhibitor and an antipsychotic or their pharmaceutically acceptable salts, hydrates, solvates, polymorphs thereof. In some embodiments, the methods and the compositions are for treating one or more positive and/or negative symptoms, as well as cognitive impairment, associated with schizophrenia or bipolar disorder (in particular, mania).. ... The Johns Hopkins University

Manipulator device and therapeutic and diagnostic methods

Dexterous manipulation devices are provided having an end effector enabling large curvature with a diameter of 1 mm or less that can articulate about an axis in a working space of about or less than 4 mm by 4 mm. Preferred devices are robotically actuated and controlled and can be used for a variety of therapeutic and diagnostic applications.. ... The Johns Hopkins University

Pre-symptomatic diagnosis of a viral illness

A method for a pre-symptomatic diagnosis of a viral illness includes obtaining a biological sample with a peripheral blood mononuclear cell from a subject. The method further includes stimulating the biological sample, where the stimulation of the biological sample includes adding to the biological sample a predetermined amount of antigen configured to trigger a t-cell ifn-γ response in the biological sample and a predetermined amount of reagent configured to capture the t-cell ifn-γ response. ... The Johns Hopkins University

Diagnostic biomarkers and therapeutic targets for pancreatic cancer

We identified >40 proteins that elicited at least a 2-fold increase in antibody response post-pancreatic-cancer vaccination, from each of three patients' sera. The antibody responses detected against these proteins in patients with >3 years disease-free survival indicates the anti-tumor potential of targeting these proteins. ... The Johns Hopkins University

Mutations of the pik3ca gene in human cancers

Phosphatidylinositol 3-kinases (pi3ks) are known to be important regulators of signaling pathways. To determine whether pi3ks are genetically altered in cancers, we analyzed the sequences of the pi3k gene family and discovered that one family member, pik3ca, is frequently mutated in cancers of the colon and other organs. ... The Johns Hopkins University

Small molecule compounds targeting pbx1 transcriptional complex

In accordance with one or more embodiments, the present invention provides a compound of formulas i, ii, and iii, for use in methods of inhibition of pbx1-dna interaction in a mammalian cell or population of cells, and for use in the treatment of medical conditions including but not limited to cancers, developmental disorders, inflammatory disorders, autoimmune diseases, or neuro-degenerative disorders.. . ... The Johns Hopkins University

05/03/18 / #20180116725

Patient-specific virtual intervention laboratory to prevent stroke

The present application relates to systems and methods for performing a computerized cardiac simulation for at least one of diagnosis, risk assessment or treatment planning including: receiving, by a computer, a plurality of three-dimensional cardiac images of a subject's heart such that each three-dimensional cardiac image corresponds to a different phase of a single cardiac cycle of the subject's heart; modeling structure, using the computer, of the left atrium of the subject as a function of time using the plurality of three-dimensional cardiac images of the subject's heart; modeling blood flow, using the computer, within, into and out of the left atrium of the subject as a function of time using computational fluidic dynamics and using structure of said left atrium obtained from at least one of said plurality of three-dimensional cardiac images or said modeling structure of said left atrium; simulating at least one of time dependent structural function or time-dependent blood flow of said left atrium using results from said modeling structure and said modeling blood flow for a selected period of time; and providing information to a user from said simulating for use in at least one of diagnosis, risk assessment or treatment planning for a physiological effect related to function of said left atrium of the subject.. . ... The Johns Hopkins University

05/03/18 / #20180116629

Catheter ultrasound transmission element (cute) catheter

An embodiment in accordance with the present invention provides a precise catheter tracking system, active ultrasound pattern injection system (auspis). Auspis establishes ultrasonic communication between any ultrasound external probe and internal catheter (cute catheter). ... The Johns Hopkins University

05/03/18 / #20180116515

A non-invasive bio-fluid detector and portable sensor-transmitter-receiver system

The present invention is directed to a bio-fluid detector such as a hemoglobin detector having the capability of receiving, storing and transmitting health information utilizing a portable transmitter and receiver including electronic pdas such as cell phones. Further, the present invention utilizes a non-invasive hemoglobin detector that is connected to a portable transmitter-receiver such as pdas including, but not limited to, cell phones.. ... The Johns Hopkins University

04/19/18 / #20180104331

Autoimmune antibodies for use in inhibiting cancer cell growth

The present disclosure provides, among other things, compositions (e.g., autoantibodies) that inhibit the growth, viability, or mobility of (invasion by) a cancer cell. Also provided are applications, such as therapeutic and diagnostic methods, in which the agents are useful, as well as screening methods for identifying autoantibodies useful in the applications.. ... The Johns Hopkins University

04/19/18 / #20180103938

Geometric biopsy plan optimization

The present invention is directed to a method for calculating tumor detection probability of a biopsy plan and for generating a 3d biopsy plan that maximizes tumor detection probability. A capsule shaped volume is modeled to represent the volume that a biopsy core may sample. ... The Johns Hopkins University

04/19/18 / #20180103886

Automated system for measurement of spatial-cognitive abilities

Described are systems for spatial cognitive ability assessment wherein a subject is able to manipulate one or more object(s) that is monitored by a device for recording motion attached to the object(s), the subject, or both that is able to generate motion electronic data. Also described are methods for assessing spatial cognitive ability.. ... The Johns Hopkins University

04/19/18 / #20180103865

Systems and methods for simulation prediction of targets for catheter ablation of left atrial flutter in patients with atrial structural remodeling

A computer-implemented method for non-invasively identifying ablation locations in atrial tissue, can include: receiving three-dimensional imaging data representing atrial tissue of a left atrial flutter (lafl) subject; generating a subject-specific model of the at least one of the atrial tissue from the three-dimensional imaging data; estimating tissue fiber orientations in the atrial tissue; assigning the estimated tissue fiber orientations to the subject-specific model of the atrial tissue; conducting simulations of lafl using the subject-specific model to identify regions of slow conduction of a propagating wave within an atrial tissue region of the atrial tissue; a critical isthmus of a rotational wavefront within the atrial tissue region; or a region based on a minimum cut in a flow network; and identifying at least one ablation location in the atrial tissue region based on the identified regions of slow conduction, the critical isthmus, or the minimum cut.. . ... The Johns Hopkins University

04/12/18 / #20180103061

Apparatus and method for implementing network deception

An example apparatus configured to perform network deception may include processing circuitry configured to generate virtual instances of decoy resources residing within a defined host network for presentation to cyber attackers, control at least one software defined network switch to monitor network traffic directed to real and decoy resources of the defined host network, and route network traffic based on detected interactions with the decoy resources. The decoy resources may have differing levels of decoy fidelity, where decoy fidelity indicates a difficulty for a cyber attacker to determine that the resource is a decoy. ... The Johns Hopkins University

04/12/18 / #20180101783

Method and apparatus for analysis and classification of high dimensional data sets

A method executable via operation of configured processing circuitry may include constructing a mutual information graph for categorical data with respect to observed attributes of a plurality of entities described in terms of respective ones of the observed attributes by the categorical data, determining a clique tree correlating attributes having at least a threshold level of mutual dependence among the observed attributes, and determining a normality rating for an entity relative to the plurality of entities based on the clique tree.. . ... The Johns Hopkins University

04/12/18 / #20180100196

Dna methylation markers for metastatic prostate cancer

The present invention relates to the field of cancer. More specifically, the present invention provides methods and compositions useful for assessing prostate cancer. ... The Johns Hopkins University

04/05/18 / #20180092977

Novel monoclonal antibody inhibitors targeting potassium channel kcnk9

The presently disclosed subject matter relates to antibodies, antibody fragments or derivatives thereof, which specifically bind to and/or interact with at least one epitope of the extracellular domain of the mammalian kcnk9 potassium channel, and to nucleic acid molecules encoding the same, as well as to vectors comprising said nucleic acid molecules. The presently disclosed subject matter provides methods for the preparation of said antibodies, antibody fragments or derivatives thereof, as well as pharmaceutical compositions, diagnostic compositions, and kits comprising the same. ... The Johns Hopkins University

04/05/18 / #20180092941

Methods of inducing vascular morphogensis

Novel hydrogels that can serve as 3d hypoxic microenvironments are disclosed. Oxygen controllable, hypoxia-inducible hydrogels (hi hydrogels) are composed of a phenolic agent and polymer backbone, which can form hydrogel networks via oxygen consumption in an enzyme-mediated crosslinking reaction. ... The Johns Hopkins University

04/05/18 / #20180092932

Anti-viral azide containing compounds

Methods of using azide-modified biomolecules, such as fatty acids, carbohydrates and lipids, to treat a plant, an insect or an animal infected with a virus or to inhibit infectivity of a virus, such as the human immunodeficiency virus, are provided. Also provided are methods of labeling a virus, such as human immunodeficiency virus, with an azide-modified biomolecule, such as a fatty acid, a carbohydrate, or an isoprenoid lipid. ... The Johns Hopkins University

03/29/18 / #provided in an embodiment is a high resolution method of detecting prostate cancer comprising utilizing a solid phase immunoassay to determine if a patient fluid shows a mic-1 value in zone m. in an embodiment, the method comprises conducting a sandwich assay in an assay device that, if the determined value is in zone m, automatically generates a report stating that a high risk of prostate cancer exists.

The Johns Hopkins University

. . ... The Johns Hopkins University

03/29/18 / #20180090684

Patterning devices using fluorinated compounds

A method for producing a spatially patterned structure includes forming a layer of a material on at least a portion of a substructure of the spatially patterned structure, forming a barrier layer of a flourinated material on the layer of material to provide an intermediate structure, and exposing the intermediate structure to at least one of a second material or radiation to cause at least one of a chemical change or a structural change to at least a portion of the intermediate structure. The barrier layer substantially protects the layer of the material from chemical and structural changes during the exposing. ... The Johns Hopkins University

03/29/18 / #20180087086

Cell egress and invasion inhibitors and their use as antiparasitical agents

The present invention provides cell egress and invasion inhibitors and their use as antiparasitical agents.. . ... The Johns Hopkins University

03/29/18 / #20180086832

Hla-restricted epitopes encoded by somatically mutated genes

Mutant epitopes encoded by cancer genes are virtually always located in the interior of cells, making them invisible to conventional antibodies. We generated single chain variable fragments (scfvs) specific for mutant peptides presented on the cell surface by human leukocyte antigen (hla) molecules. ... The Johns Hopkins University

03/29/18 / #20180085594

Method and device for treating cardiac arrhythmias

The present invention provides both methods and devices for termination of arrhythmias, such as ventricular or atrial tachyarrhythmias. The device and method involves application of alternating current (ac) for clinically significant durations at selected therapeutic frequencies through the cardiac tissue to a subject experiencing arrhythmia. ... The Johns Hopkins University

03/29/18 / #20180085478

Labeled inhibitors of prostate specific membrane antigen (psma) biological evaluation, and use of imaging agents

The prostate-specific membrane antigen (psma) is increasingly recognized as a viable target for imaging and therapy of cancer. Various 99mtc/re-labeled compounds were prepared by attaching known tc/re chelating agents to an amino-functionalized psma inhibitor with or without a variable length linker moiety. ... The Johns Hopkins University

03/29/18 / #20180085446

Immunogenic fusion proteins for the treatment of cancer

Provided herein are compositions and methods for eliciting an immune response in a subject. In particular, the present disclosure is directed to immunogenic fusion proteins and methods of eliciting an immune response using host cells comprising nucleic acid molecules encoding said fusion proteins.. ... The Johns Hopkins University

03/22/18 / #20180081032

Optical detection system

An active optical detection system includes an optical transmitter configured to transmit light in a signal pattern and an optical receiver configured to receive light and determine a correlation between the received light and the signal pattern. The correlation of the received light and the signal pattern is indicative of range to an object.. ... The Johns Hopkins University

03/22/18 / #20180080062

Enrichment of nucleic acids by complimentary capture

Assays can be used to detect mutations found in neoplasms of the pancreas, as well as for other neoplasms and other uses. Nucleic acids can be captured from body fluids such as cyst fluids. ... The Johns Hopkins University

03/22/18 / #20180079813

Anti-h7cr antibodies

Antibodies and humanized variants thereof and their antigen-binding fragments and other molecules that are capable of immunospecifically binding to the b7-h7 counter-receptor, and their uses in enhancing immune responses and the treatment and diagnosis of cancer and other diseases are provided.. . ... The Johns Hopkins University

03/22/18 / #20180078312

Systems and methods for patient-specific modeling of the heart for prediction of targets for catheter ablation of ventricular tachycardia in patients with implantable cardioverter defibrillators

A system, computer-readable medium and method can include receiving three-dimensional imaging data of a subject's heart, the subject having an icd, wherein the icd causes an imaging artifact in the three-dimensional imaging data that includes regions that are free of the artifact and regions that are affected by the artifact; segmenting the regions that are free of the artifact into a plurality of normal tissue regions and remodeled tissue regions for the subject; extrapolating from the regions that are free of the artifact to provide extrapolated three-dimensional imaging data corresponding to the regions that are affected by the artifact; and simulating at least one of electrophysiological or electromechanical activity of the subject's heart using the segmented and extrapolated three-dimensional imaging data, the simulating including providing a preselected alteration of electrophysiological or electromechanical behavior of the subject's heart for a target of said subject-specific cardiac ablation procedure.. . ... The Johns Hopkins University

03/15/18 / #20180075597

Tissue characterization based on machine learning in medical imaging

Tissue is characterized using machine-learnt classification. The prognosis, diagnosis or evidence in the form of a similar case is found by machine-learnt classification from features extracted from frames of medical scan data. ... The Johns Hopkins University

03/15/18 / #20180072999

Trichoplusia ni piggybac transposases with reduced integration activity

The present invention is directed to nucleic acid and amino acid sequences of a novel piggybac transposase enzymes created by modifying the transposase of trichoplusia ni. The piggybac transposases of the present invention are functionally active or hyperactive for excision and have decreased integration activity compared to wild type trichoplusia ni piggybac transposase enzyme. ... The Johns Hopkins University

03/15/18 / #20180070963

Bone harvesting

Methods and devices for harvesting cancellous bone are disclosed. The bone-harvesting device may include a cannula and a bone receptacle in communication with the cannula, wherein the cannula including a cutting surface positioned at or adjacent the distal end, the cutting surface being oriented at an angle, the angle being greater than 90 degrees relative to the longitudinal axis of the cannula, and the harvested bone is adapted to move from a position adjacent to the cutting surface through the cannula into the bone receptacle. ... The Johns Hopkins University

03/08/18 / #20180067865

Apparatus and method for computational workflow management

Apparatuses and methods for performing computational workflow management are provided. An example apparatus may include processing circuitry. ... The Johns Hopkins University

03/08/18 / #20180066056

Anti-h7cr antibodies

Antibodies and humanized variants thereof and their antigen-binding fragments and other molecules that are capable of immunospecifically binding to the b7-h7 counter-receptor, and their uses in enhancing immune responses and the treatment and diagnosis of cancer and other diseases are provided.. . ... The Johns Hopkins University

03/08/18 / #20180064746

Assay for telomere length regulators

The present invention provides an assay that identifies genes required for telomerase-dependent telomere elongation by measuring the de novo telomere addition at a single chromosome.. . ... The Johns Hopkins University

03/08/18 / #20180064641

Compositions and methods for ophthalmic and/or other applications

Particles, compositions, and methods that aid particle transport in mucus are provided. The particles, compositions, and methods may be used, in some instances, for ophthalmic and/or other applications. ... The Johns Hopkins University

03/01/18 / #20180061080

Point source image blur mitigation

Apparatuses and methods for point source image blur mitigation are provided. An example method may include receiving, from an imaging detector, a plurality of pixel signals associated with respective pixels of an image over a stare time, and determining a trajectory of a point source within the image due to relative angular motion of the point source across a plurality of pixels of the image. ... The Johns Hopkins University

03/01/18 / #20180055640

Method for manufacturing a low-profile intercranial device and the low-profile intercranial device manufactured thereby

A low-profile intercranial device including a low-profile static cranial implant and a functional neurosurgical implant. The low-profile static cranial implant and the functional neurosurgical implant are virtually designed and interdigitated prior to physical assembly of the low-profile intercranial device.. ... The Johns Hopkins University

02/22/18 / #20180051039

68ga-labeled nota-chelated psma-targeted imaging and therapeutic agents

Psma-targeted pet/spect agents for imaging psma-positive cancer and or tumor neovasculature and psma-targeted radiotherapeutic agent for the treatment of psma-positive cancer or tumor neovasculature are disclosed. Methods of imaging psma expressing tumors, or cells and kits also are disclosed.. ... The Johns Hopkins University

02/22/18 / #20180050994

Rufinamide and derivatives and their use in modulating the gating process of human voltage-gated sodium channels

The present invention provides compounds of formula i or a salt, solvate, or stereoisomer thereof, wherein x is h, or an electron withdrawing group such as a halogen, nh2, no2, so2, cn, or a c1-c6 alkyl group; alk is c1-c3 alkyl; r1 is h, c1-c6 alkyl, which may be substituted with oh, nh2, acyl, sulfonyl, and cyano groups; and r2, is c1-c6 alkyl, which may be substituted with oh, nh2, acyl, sulfonyl, and cyano groups. Pharmaceutical compositions comprising these compounds and/or rufinamide are also provided. ... The Johns Hopkins University

02/22/18 / #20180050130

Composite material for tissue restoration

A composite material can include a gel and at least one nanostructure disposed within the gel. A method for healing a soft tissue defect can include applying a composite material to a soft tissue defect, wherein the composite material includes a gel and a nanostructure disposed within the gel. ... The Johns Hopkins University

02/22/18 / #20180050090

Compositions and methods for sensitizing cells to trail-induced apoptosis

The present invention comprises pegylated trail peptides and their use in conjunction with various trail sensitizing agents in tumor homing nanoparticle formulations for use in the treatment of cancer in a subject.. . ... The Johns Hopkins University

02/15/18 / #20180043162

Neuromodulation device

The invention provides devices and methods that can prevent or ameliorate bronchoconstriction. In particular, the invention provides devices and methods in which a signal is delivered to the vagus nerve or the pulmonary branches of the vagus nerves. ... The Johns Hopkins University

02/15/18 / #20180043003

Reagents and methods for identifying, enriching, and/or expanding antigen-specific t cells

Antigen-specific t cells, including nave t cells, and including rare precursor cells are enriched and expanded in culture. Enrichment and expansion provides a platform for more effective immunotherapy by adoptive transfer, as well as platforms for personalizing immunotherapy by determining t cell reactivity with a library of candidate peptide antigens.. ... The Johns Hopkins University

02/15/18 / #20180042680

Interactive user interfaces for minimally invasive telesurgical systems

In one embodiment of the invention, a a minimally invasive surgical system is disclosed. The system configured to capture and display camera images of a surgical site on at least one display device at a surgeon console; switch out of a following mode and into a masters-as-mice (mam) mode; overlay a graphical user interface (gui) including an interactive graphical object onto the camera images; and render a pointer within the camera images for user interactive control. ... The Johns Hopkins University

02/15/18 / #20180042494

Device and method to measure ventricular arterial coupling and vascular performance

A device for measuring a ventricular-arterial coupling of a subject includes first and second inputs. The first input receives signals from a plurality of electrocardiogram sensors that are coupled to the subject at a plurality of first locations. ... The Johns Hopkins University

02/15/18 / #20180042466

Compact endoscope design for three-dimensional surgical guidance

The present invention is directed to endoscopic structure illumination to provide simple, inexpensive 3d endoscopic technique to conduct high resolution 3d imagery for use in surgical guidance system. The present invention is directed to an fpp endoscopic imaging setup which provides a wide field of view (fov) that addresses a quantitative depth information and can be integrated with commercially available endoscopes to provide tissue profilometry. ... The Johns Hopkins University

02/08/18 / #20180037621

Compositions and methods for enhancing an immune response

The disclosure features compounds comprising an antigen portion, a soluble major histocompatibility complex (mhc) molecule portion (e.g., all or an antigen-binding portion of a soluble mhc class i molecule), and a dynamic anchor portion (e.g., an agent, such as annexin v, that binds to phosphatidylserine). The featured compounds are useful for a variety of therapeutic applications, including, e.g., enhancing a t cell response to an antigen of interest or enhancing a t cell-driven immune response by a subject to an antigen of interest (e.g., a cancer antigen or a microbial antigen).. ... The Johns Hopkins University

02/08/18 / #20180036549

Device for magnetic stimulation of the vestibular system

The present invention is directed to a magnetic vestibular stimulation (mvs) system for rehabilitation of subjects with vestibular and balance disorders. The magnetic vestibular stimulation system includes a magnet and a cooling system. ... The Johns Hopkins University

02/08/18 / #20180036354

Cvs transplantation for treatment of bacterial vaginosis

Methods and materials for treating bacterial vaginosis (“bv”) are provided. Cervicovaginal secretions (“cvs”) from a woman with lactobacillus crispatus-dominated (>50%) vaginal microbiota is transplanted to women with bv as a method for restoring beneficial vaginal microbial communities and/or increasing resistance to sexually transmitted disease. ... The Johns Hopkins University

02/08/18 / #20180036301

Local delivery forms of acriflavine for treating tumors

Local delivery formulations of the antineoplastic and microbicide agent acriflavine, and methods of making and using thereof are significantly more efficacious at increasing the median survival of subjects with proliferative disease than systemic administrations of acriflavine. The local delivery formulations of acriflavine show a dose-dependent increase in the median survival of subjects. ... The Johns Hopkins University

02/08/18 / #20180036264

Targeting liver nuclear receptors as a treatment for wilson disease

The present invention relates to the field of wilson disease. More specifically, the present invention provides methods and compositions useful for treating wilson disease by targeting liver nuclear receptors. ... The Johns Hopkins University

02/01/18 / #20180031576

A novel nervous system-specific transmembrane proteasome complex that modulates neuronal signaling through extracellular signaling via brain activity peptides

The inventors surprisingly found that neural stimulation caused the synthesis and degradation of proteins into peptides which were then secreted into the cell media within minutes of stimulation by a novel neural-specific and membrane bound proteasome (neuronal membrane proteasome or nmp) that is transmembrane in nature. These secreted, activity-induced, proteasomal peptides (snapps) range in size from about 500 daltons to about 3000 daltons. ... The Johns Hopkins University

02/01/18 / #20180030086

Methods and systems for generating, validating and using monoclonal antibodies

Provided herein is a library of antibodies, wherein the library of antibodies can comprise a plurality of monoclonal, monospecific, or immunoprecipitating antibodies. Also provided herein is a method for producing and using the library of antibodies.. ... The Johns Hopkins University

02/01/18 / #20180028687

Extracellular vesicles for agent delivery

The present invention relates to the field of extracellular vesicles. More specifically, the present invention provides methods and compositions for using extracellular vesicles as a vector for nucleic acid treatment in vivo of various diseases. ... The Johns Hopkins University

02/01/18 / #20180028455

Peptide/particle delivery systems

Polymeric nanoparticles, microparticles, and gels for delivering cargo, e.g., a therapeutic agent, such as a peptide, to a target, e.g., a cell, and their use for treating diseases, including angiogenesis-dependent diseases, such as age-related macular degeneration and cancer, are disclosed. Methods for formulating, stabilizing, and administering single peptides or combinations of peptides via polymeric particle and gel delivery systems also are disclosed.. ... The Johns Hopkins University

02/01/18 / #20180028165

Method and device for statistical tissue sampling using microdevices

The present invention utilizes tetherless microtools to biopsy tissue. The invention provides a device and method for deployment and retrieval of tetherless microtools. ... The Johns Hopkins University

02/01/18 / #20180028127

Extremity imaging apparatus for cone beam computed tomography

An apparatus for cone beam computed tomography can include a support structure, a scanner assembly coupled to the support structure for controlled movement in at least x, y and z orientations, the scanner assembly can include a dr detector configured to move along at least a portion of a detector path that extends at least partially around a scan volume with a distance d1 that is sufficiently long to allow the scan volume to be positioned within the detector path; a radiation source configured to move along at least a portion of a source path outside the detector path, the source path having a distance d2 greater than the distance d1, the distance d2 being sufficiently long to allow adequate radiation exposure of the scan volume for an image capture by the detector; and a first gap in the detector path.. . ... The Johns Hopkins University

01/25/18 / #20180021435

Hypotonic hydrogel formulations for enhanced transport of active agents at mucosal surfaces

Hypotonic formulations of hydrogel forming polymers, preferably poloxamers, have been developed for enhanced delivery through mucosa of therapeutic, diagnostic, prophylactic or other agents, to epithelial tissues, especially those having a mucosal coating. The polymers are administered at a concentration above, at or less than their critical gelling concentration (cgc) under isotonic conditions. ... The Johns Hopkins University

01/25/18 / #20180021310

Mebendazole polymorph for treatement and prevention of tumors

Mebendazole is an antiparasitic drug with over 40 years of safe use. Recently mebendazole was repurposed for glioblastoma therapy. ... The Johns Hopkins University

01/25/18 / #20180021306

Inhibition of yap for breaking tumor immune tolerance

Yes-associated protein (yap), a downstream co-activator of the hippo pathway, is highly expressed in the treg cell subset, and is critical to maintain its suppressive activity. Originally discovered in drosophila melanogaster, the hippo signaling pathway is a major regulator of cellular growth and proliferation in mammals. ... The Johns Hopkins University

01/25/18 / #20180020985

Optical imaging system and method of making and using the same

An optical imaging system for interfacing with a separate examination apparatus and methods of making and using the same are disclosed. The optical imaging system can include an imaging housing including a housing enclosure and a housing receptor plate, a subject support mount, a cart including an extendable arm, an optical arrangement including an optical source, a cantilever mirror system, and the housing enclosure, and a detection optical path providing optical communication between the cantilever mirror system and an optical detector. ... The Johns Hopkins University

01/18/18 / #20180015153

Compounds and methods for treatment and prevention of flavivirus infection

The present invention concerns the use of compounds for the treatment or prevention of flavivirus infections, such as zika virus infections. Aspects of the invention include methods for treating or preventing flavivirus virus infection, such as zika virus infection, by administering a compound or class of compound disclosed herein, such as a niclosamide compound, an emricasan compound, a cyclin-dependent kinase inhibitor, a proteasome inhibitor, or a combination of two or more of the foregoing, to a subject in need thereof; methods for inhibiting flavivirus infections such as zika virus infections in a cell in vitro or in vivo; pharmaceutical compositions; packaged dosage formulations; and kits for treating or preventing flavivirus infections, such zika virus infections.. ... The Johns Hopkins University

01/18/18 / #20180015109

Methods and compositions for improving cognitive function

The invention relates to methods and compositions for improving cognitive function by using a combination of a synaptic vesicle protein 2a (sv2a) inhibitor and an acetylcholinesterase inhibitor (achei) or their pharmaceutically acceptable salts, hydrates, solvates, polymorphs thereof. In particular, it relates to the use of a combination of an sv2a inhibitor and an achei in treating a central nervous system disorder with cognitive impairment in a subject in need or at risk thereof, including, without limitation, subjects having or at risk for age-related cognitive impairment, mild cognitive impairment (mci), dementia, alzheimer's disease (ad), prodromal ad, post traumatic stress disorder (ptsd), schizophrenia, amyotrophic lateral sclerosis (als), and cancer-therapy-related cognitive impairment.. ... The Johns Hopkins University

01/11/18 / #20180010183

Methods for characterizing and treating cognitive impairment in aging and disease

This invention provides methods for identifying genes associated with cognitive impairment and for identifying compounds useful in the treatment of cognitive impairment. The methods can in particular be used to identify genes associated with, and compounds useful in treating, cognitive impairment in aging.. ... The Johns Hopkins University

01/11/18 / #20180009859

Pharmacological modulators of gabaa receptors and their use

The present invention provides polypeptides and their variants and derivatives which modulate gabaa receptor function at nanomolar quantities by binding to the α+/β− subunit interface, as well as methods of making and using the same. The inventive peptides are useful for the study of neurological disease and function and can have therapeutic applications.. ... The Johns Hopkins University

01/11/18 / #20180008668

Albumin-proaerolysin prodrugs

The present invention relates to the field of cancer. More specifically, the present invention provides compositions and methods for treating cancer using albumin-proaerolysin prodrugs. ... The Johns Hopkins University

01/11/18 / #20180008541

Cyclodextrin compositions encapsulating a selective atp inhibitor and uses thereof

The invention provides compositions comprising cyclodextrins encapsulating a selective atp inhibitor, as well as uses thereof.. . ... The Johns Hopkins University

01/04/18 / #20180000983

Hydrogels and use thereof in anastomosis procedures

This disclosure provides novel hydrogels that can undergo multiple gel-sol transitions and methods of making and using such hydrogels, particularly in anastomosis procedures. The peptide hydrogels comprising a fibrillar network of peptides that are in an amphiphilic β-hairpin conformation. ... The Johns Hopkins University

01/04/18 / #20180000548

Delta mechanism with enhanced torsional stiffness

A mechanical translation apparatus includes a translation stage and a translation assembly operatively connected to the translation stage so as to impart linear motions to the translation stage substantially free of rotational motions. The translation assembly includes a plurality of at least three arms pivotably connected to the translation stage at a first end of each arm of the plurality of at least three arms. ... The Johns Hopkins University

12/28/17 / #20170370998

Battery internal temperature sensing battery management system

A method is provided. The method is executable by a processor of a battery management system. ... The Johns Hopkins University

12/28/17 / #20170370945

Biomarkers useful in the treatment of subjects having disease of the eye

The present invention provides biomarkers of oxidative stress in subjects with retinitis pigmentosa, age-related macular degeneration, diabetic retinopathy, fuchs' dystrophy, diabetic macular edema (dme), geographic atrophy, stargardt's disease, or retinal vein occlusion (rvo), and their use in identifying subjects in need of treatment and methods for staging the severity of the disease.. . ... The Johns Hopkins University

12/28/17 / #20170370943

Citrullinated brain and neurological proteins as biomarkers of brain injury or neurodegeneration

The present invention relates to the field of biomarkers. More specifically, the present invention relates to biomarkers useful in diagnosing brain injury or neurodegeneration. ... The Johns Hopkins University

12/28/17 / #20170369855

Systems and methods for genome modification and regulation

The present invention provides methods of systems and methods of site specific methylation.. . ... The Johns Hopkins University

12/28/17 / #20170368557

Systems and methods for separating metallic and nonmetallic particles in a mixed-particle suspension

A continuous flow particle separation system for separating metallic and nonmetallic particles from a mixed-particle suspension includes a fluid channeling component defining an input channel and first and second output channels fluidly connected to the input channel at a bifurcated junction, a first electrode and a second electrode arranged proximate the input channel at least partially prior to the bifurcated junction, and an alternating current (ac) electric power source electrically connected to the first and second electrodes. The first and second electrodes have shapes configured to provide a spatially-gradient electric field across the input channel, and the ac electric power source is configured to provide an ac electric potential to the first and second electrodes to cause a separation of the metallic and nonmetallic particles by dielectrophoresis due to a difference in dielectrophoretic forces imposed on the metallic particles relative to those of the nanometallic particles such that first output fluid flow in the first output channel has an enriched concentration of metallic particles and second output fluid flow in the second output channel has an enriched concentration of nonmetallic particles relative to the mixed-particle suspension in said input channel.. ... The Johns Hopkins University

12/28/17 / #20170368304

Pre-curved steerable catheter with pull-wires for dexterous deflection control

A pre-curved steerable catheter includes a catheter body (102) having a distal end portion. The distal end portion includes a permanently curved flexible end portion (110). ... The Johns Hopkins University

12/28/17 / #20170368070

Combination therapy for tuberculosis

The present invention relates to methods of treating tuberculosis, including multidrug resistant varieties and latent tuberculosis. More particularly, the present invention relates to a method of treating tuberculosis in a mammal comprising administering to said mammal in need thereof an effective amount of a compound of formula (t), (s)—n-[[3-[3-fluoro-4-(4-thiomor-pholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]acetamide, or a pharmaceutically acceptable salt thereof in combination with at least two agents useful in the treatment of tuberculosis. ... The Johns Hopkins University

12/28/17 / #20170367723

Endoscopic gastric mucosal ablation/resection/exclusion (a/r/e) as a minimally invasive weight loss approach

The present invention is directed to a method of endoscopically ablating/resecting/excluding (a/r/e) the mucosa of the gastric fundus and body. The method of the present invention is intended to cause cellular death to the x/a-like, ghrelin producing and other hormone cells. ... The Johns Hopkins University

12/21/17 / #20170362659

Consensus coding sequences of human breast and colorectal cancers

Analysis of 13,023 genes in 11 breast and 11 colorectal cancers revealed that individual tumors accumulate an average of ˜90 mutant genes but that only a subset of these contribute to the neoplastic process. Using stringent criteria to delineate this subset, we identified 189 genes (average of 11 per tumor) that were mutated at significant frequency. ... The Johns Hopkins University

12/21/17 / #20170362560

System and method for conditioning of engineered tissues

A system and method for conditioning a tissue are provided. The system includes a substrate, a plurality of microwells formed in the substrate, and a microsphere associated with each of the plurality of microwells. ... The Johns Hopkins University

12/21/17 / #20170361074

Implantable body-driven shunt pump

An implantable, body-driven shunt pump includes a pump body defining a fluid inlet, a fluid outlet and a fluid chamber therebetween; an inlet valve arranged in the fluid inlet, the inlet valve being a one-way valve arranged such that it is operable to allow fluid flow into the fluid chamber and to prevent fluid flow out of the fluid chamber; and an outlet valve arranged in the fluid outlet, the outlet valve being a one-way valve arranged such that it is operable to allow fluid flow out of the fluid chamber and to prevent fluid flow into the fluid chamber. The pump body includes an expandable and contractible component in a portion of the pump body that defines the fluid chamber such that the fluid chamber changes volume in response to a change in pressure of fluid in the fluid chamber.. ... The Johns Hopkins University

12/21/17 / #20170360920

Method and compositions for the prevention and treatment of a hiv infection

Described herein are methods of preventing or treating a hiv infection comprising administering to a mammal in need thereof, a pharmaceutically effective amount of a cd8+ t cell vaccine composition. Such methods comprising using cd8+ t cells which have been pre-stimulated with at least one hiv epitope, to thereby enhance a cd8+ t cell immune response against hiv in said mammal.. ... The Johns Hopkins University

12/21/17 / #20170360750

Sunitinib formulations and methods for use thereof in treatment of glaucoma

Methods for increasing the encapsulation or incorporation of sunitinib into polymeric matrices have been developed. The resulting formulations provide for more sustained controlled release of sunitinib or other inhibitors of jnk signaling, which bind to dlk. ... The Johns Hopkins University

12/14/17 / #20170357753

Direct estimation of patient attributes based on mri brain atlases

The present invention is directed to a context-based image retrieval (cbir) system for disease estimation based on the multi-atlas framework, in which the demographic and diagnostic information of multiple atlases are weighted and fused to generate an estimated diagnosis, on a structure-by-structure basis. The present invention demonstrates high accuracy in age estimation, as well as diagnostic estimation in alzheimer's disease. ... The Johns Hopkins University

12/14/17 / #20170356478

Three dimensional woven lattices for drag reduction and turbulence reduction

The present invention is directed to three dimensional (3d) woven lattices for drag and turbulence reduction. 3d woven lattice material can serve as a surface layer that regularizes the flow around a bluff body with beneficial effects on: 1) drag reduction, 2) decrease in turbulence intensity, 3) attenuation of flow-induced vibrations, and 4) aerodynamic noise cancellation. ... The Johns Hopkins University

12/14/17 / #20170355997

Methods and compositions for treating or preventing pruritis

The invention features therapeutic compositions comprising agents useful for the treatment or prevention of pruritis, and methods useful for identifying such agents.. . ... The Johns Hopkins University

12/14/17 / #20170355951

Mosquito salivary gland extraction device and methods of use

A device and method of use for augmenting the extraction of salivary glands from plasmodium-infected mosquitoes, where the sporozoite stage of plasmodium primarily resides. Sporozoites are useful for research as well as for the immunogen in whole parasite vaccines for the prevention of malaria. ... The Johns Hopkins University

12/07/17 / #20170348307

Methods and compositions for killing senescent cells and for treating senescence-associated diseases and disorders

Methods are provided herein for selectively killing senescent cells and for treating senescence-associated diseases and disorders by administering a senolytic agent. Senescence-associated diseases and disorders treatable by the methods using the senolytic agents described herein include cardiovascular diseases and disorders associated with or caused by arteriosclerosis, such as atherosclerosis; idiopathic pulmonary fibrosis; chronic obstructive pulmonary disease; osteoarthritis; senescence-associated ophthalmic diseases and disorders; and senescence-associated dermatological diseases and disorders.. ... The Johns Hopkins University

11/30/17 / #20170342599

Electrospinning aramid nanofibers

Example methods and articles of manufacture related to electrospun aramid nanofibers are provided. One example method may include forming a resultant solution by reacting a solution of aramids dissolved in a solvent with an electrophile. ... The Johns Hopkins University

11/30/17 / #20170342399

Chaotrope- and volatile-free method for purifying nucleic acids from plasma

The presently disclosed subject matter provides methods and kits for purifying nucleic acids from blood plasma using a functionalized solid phase comprising a silica or polymer backbone and non-chaotropic and ethanol-free buffers.. . ... The Johns Hopkins University

11/30/17 / #20170340709

Methods of treatment using stem cell mobilizers

The present invention relates to the field of stem cells. In one aspect, the present invention provides methods of treating a subject with acute liver injury comprising administering to the subject a therapeutically effective amount of at least one stem cell mobilizer. ... The Johns Hopkins University

11/30/17 / #20170340595

Compositions and methods for treating autism spectrum disorders

The instant disclosure features, among other things, compositions and methods for treating an autism spectrum disorder in a human. The compositions comprise an effective amount of: (1) an isothiocyanate (e.g., sulforaphane or a derivative thereof) or (2) a glucosinolate, and optionally, an enzyme, to thereby treat an autism spectrum disorder and/or reduce the severity of at least one symptom of the disorder. ... The Johns Hopkins University

11/30/17 / #20170340354

Image-guided embryo transfer for in vitro fertilization

A method for performing image-guided embryo transfer for in vitro fertilization includes performing a pre-operative magnetic resonance imaging (mri) scan of a subjects pelvic region to yield a first mri image dataset. A computer applies a segmentation routine to the first mri image dataset to yield segment data which is then used by the computer to create an anatomical model of the subjects pelvic region. ... The Johns Hopkins University

11/23/17 / #20170336387

Aggregation-assisted separation of plasma from whole blood

Methods for separating blood plasma from whole blood in the absence of performing centrifugation are provided. The method combines mechanical filtration and blood cell aggregation and is adapted for use in poc clinical testing.. ... The Johns Hopkins University

11/23/17 / #20170335442

Method for forming binder-free refractory carbide, nitride and boride coatings with a controlled porosity

The present invention is directed to methods for formation of refractory carbide, nitride, and boride coatings without use of a binding agent. The present invention is directed to methods of creating refractory coatings with controlled porosity. ... The Johns Hopkins University

11/23/17 / #20170333576

New scaffolds and multifunctional intermediates for imaging psma and cancer therapy

Carbamate and beta-amino acid urea-based scaffolds that have high binding affinity to psma are disclosed. These scaffolds can be radiolabeled and used for imaging cells and tumors that express psma or for cancer radiotherapy. ... The Johns Hopkins University

11/23/17 / #20170333375

Treatment of retinitis pigmentosa with n-acetylcysteine amide

The present invention includes a method for the treatment of retinitis pigmentosa in a human that comprises adminisering to the human a therapeutically effective amount of n-acetylcysteine amide (naca). In accordance with an embodiment, the present invention provides a method for the treatment of retinitis pigmentosa in an animal that comprises administering to the animal a therapeutically effective amount of n-acetylcystein amide (naca).. ... The Johns Hopkins University

11/16/17 / #20170327898

Ovarian carcinoma detection and prophylaxis

The evolutionary origin of high-grade serous ovarian carcinoma remains largely unknown. The vast majority of tumor-specific genomic alterations from ovarian cancers are present in fallopian tube stic lesions (average of 55 sequence alterations per tumor), including those affecting tp53, brca1, brca2 or pten genes. ... The Johns Hopkins University

11/16/17 / #20170327543

Polyionic papilloma virus-like particle (vlp) vaccines

The present invention relates to the field of vaccines. In particular, the present invention provides compositions and methods relating to virus-like particle (vlp) vaccines. ... The Johns Hopkins University

11/16/17 / #20170326136

Treatment of pain

This disclosure provides a technology for managing the sensation of pain in a subject in need thereof. Treatment methods according to this invention include administering to the subject a formulation that contains an effective amount of (4-[(4s,5r)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1h-imidazol-1-yl]carbonyl]-2-piperazinone).. ... The Johns Hopkins University

11/09/17 / #20170323118

Apparatus and method for private information retrieval

Apparatuses and methods for private information retrieval are provided. One example method may include receiving a query state machine that is an encoding of a search pattern. ... The Johns Hopkins University

11/09/17 / #20170321278

Detection and treatment of polycystic kidney disease

Compositions useful for examining the pkd1 gene are provided. In addition, methods for detecting mutations of the pkd1 gene, which can be associated with autosomal dominant polycystic kidney disease in humans, are provided. ... The Johns Hopkins University

11/09/17 / #20170319278

Systems and methods for atrial fibrillation treatment and risk assessment

According to some embodiments of the invention, a method for providing an atrial fibrillation (af) ablation treatment plan includes receiving imaging data for at least a portion of an atrial region of a subject's heart, and processing the imaging data to characterize tissue as one of fibrotic tissue or non-fibrotic tissue. The method further includes calculating a metric of spatial distribution of at least a portion of the tissue characterized as fibrotic tissue from the processing the imaging data, identifying a cardiac tissue ablation target based on the metric, and providing an af treatment plan that includes the cardiac tissue ablation target as at least a portion of the af treatment plan.. ... The Johns Hopkins University

10/26/17 / #20170311101

Middle ear implant sensor

A middle ear implant may include a first interface portion configured to interface with a first structure of a middle ear of a patient, a second interface portion configured to interface with a second structure of the middle ear of the patient, a shaft configured to connect the first interface portion and the second interface portion, and a sensor disposed at one end of the shaft, between the shaft and one of the first interface portion or the second interface portion. The sensor may be configured to provide a dc signal output indicative of static pressure on the sensor based on placement of the sensor between the first and second structures. ... The Johns Hopkins University

10/26/17 / #20170305990

Tmem100 peptides and variants thereof and their use in treating or preventing diseases or conditions

The present invention features compositions of tmem100 peptides and variants thereof, and their use in treating or preventing diseases or conditions.. . ... The Johns Hopkins University

10/26/17 / #20170305847

N-hydroxylsulfonamide derivatives as new physiologically useful nitroxyl donors

The invention relates to n-hydroxysulfonamide derivatives that donate nitroxyl (hno) under physiological conditions and are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure and ischemia/reperfusion injury. Novel n-hydroxysulfonamide derivatives release nho at a controlled rate under physiological conditions, and the rate of hno release is modulated by varying the nature and location of functional groups on the n-hydroxysulfonamide derivatives.. ... The Johns Hopkins University

10/26/17 / #20170304214

Therapeutic electrospun fiber compositions

The instant invention provides electrospun fiber compositions comprising one or more polymers and one or more biologically active agents. In specific embodiments, the biologically active agents are nerve growth factors. ... The Johns Hopkins University

10/12/17 / #20170295337

Flexible readout and signal processing in a computational sensor array

A computational sensing array includes an array of sensing elements. In each sensing element, a first signal is generated from a transducer. ... The Johns Hopkins University

10/12/17 / #20170293008

Measurement of blood volume using velocity-selective pulse trains on mri

The present invention is directed to a system and method for measuring blood volume using non-contrast-enhanced magnetic resonance imaging. The method of the present invention includes a subtraction-based method using a pair of acquisitions immediately following velocity-sensitized pulse trains for the label module and its corresponding control module, respectively. ... The Johns Hopkins University

10/12/17 / #20170292963

Biomarkers of cognitive dysfunction

The present invention relates to the field of cognitive function. More specifically, the present invention provides compositions and methods useful for assessing cognitive dysfunction/function in alzheimer's disease and other diseases of cognition. ... The Johns Hopkins University

10/12/17 / #20170291030

System and method for brain stimulation for improvement of motor symptoms in parkinson's disease and other movement disorders

An embodiment in accordance with the present invention is directed to a system and device for applying electrical direct current transcranially to the brain that is combined with a behavioral activity consisting of an isometric force production task. The device is non-invasive or implantable and serves to improve motor symptoms in parkinson's disease (pd) and other movement disorders. ... The Johns Hopkins University

10/05/17 / #20170288114

Thermoelectric polymer composites

An embodiment of the present disclosure is directed to a thermoelectric polymer composite. The composite comprises: at least one polymer selected from semiconducting polymers and conducting polymers; and at least one particle inclusion having one or more dimensions of 1 millimeter or less and at least one dimension of 10 nanometer or more. ... The Johns Hopkins University

10/05/17 / #20170281463

Ecg artifact reduction system

An ecg signal processing system which removes the cpr-induced artifact from measured ecg signals obtained during the administration of cpr.. . ... The Johns Hopkins University

10/05/17 / #20170280730

Compositions and methods useful for the prevention of malaria and dengue virus transmission

The present invention relates to the fields of malaria and dengue virus. More specifically, the present invention provides compositions and methods useful for the treatment and prevention of malaria and dengue virus. ... The Johns Hopkins University

09/28/17 / #20170276742

Sterile rf coils for mr imaging systems

Sterile rf coil arrangements for use in magnetic resonance imaging are provided. The sterile coil arrangements can be formed by spraying or coating a curable liquid onto an rf coil housing and allowing the liquid to cure or dry to form a continuous sterile layer on the coil housing. ... The Johns Hopkins University

09/28/17 / #20170276688

Anti-himf antibodies to treat lung diseases

Hypoxia induced mitogenic factor (himf) is a member of the “found in inflammatory zone” (fizz)/resistin family of proteins and has potent mitogenic, angiogenic, and vasoconstrictive effects in the lung vasculature. The receptor/binding partners for this family of proteins have been largely unknown. ... The Johns Hopkins University

09/28/17 / #20170276687

Compositions and methods for detecting anti-endothelial cell antibodies in allograft rejection

Provided herein are methods, compositions, and kits for diagnosing allograft rejection of organ transplants by identifying the presence of anti-endothelial cell antibodies. Such methods and compositions are independent of external confounders such as recipient age, transplant center, assay, cause of end-stage disease, co-morbidities, immunosuppression usage, and the like.. ... The Johns Hopkins University

09/28/17 / #20170275705

Biomarkers useful for determining response to pd-1 blockade therapy

Pd-l1 expression by tumor cells prior to treatment correlates highly with response to anti-pd-1 and anti-pd-l1 therapy (e.g., nivolumab (bristol-myers squibb), pembrolizumab (merck)) and anti-pd-l1 monotherapy (mpdl3280a (genentech/roche)). Nonetheless, the majority of patients with pd-li(+) tumors do not respond to pd-1 pathway blockade. ... The Johns Hopkins University

09/28/17 / #20170275673

Methods and compositions related to prostate cancer therapeutics

Disclosed herein are compositions and methods for detecting biological molecules and biomarkers associated with prostate cancer. Disclosed herein are compositions and methods for detecting biological molecules and biomarkers associated with castration-resistant prostate cancer wherein such biological molecules and biomarkers comprise androgen-receptor splice variants that can be used to develop effective therapeutic regimens for prostate cancer patients. ... The Johns Hopkins University

09/28/17 / #20170274102

Post-surgical imaging marker

A marker for imaging includes a bio-dissolvable material and a contrast agent configured to provide contrast during an imaging procedure. A method can include forming a marker for imaging from a bio-dissolvable material and impregnating the bio-dissolvable material with a contrast agent. ... The Johns Hopkins University

09/28/17 / #20170273901

Sunitinib formulations and methods for use thereof in treatment of ocular disorders

Methods for increasing the encapsulation or incorporation of sunitinib into polymeric matrices have been developed. The resulting formulations provide for more sustained controlled release of sunitinib or its analog or a pharmaceutically acceptable salt thereof. ... The Johns Hopkins University

09/28/17 / #20170273797

Computer-assisted cranioplasty

Provided is a surgical method. The method includes detecting a location of a reference unit having a trackable element with a detector, the detector configured to provide at least one signal corresponding to a detected location of at least the reference unit's trackable element, wherein the reference unit is associated with a location of an anatomical feature of a being's anatomy; accessing a computer-readable reconstruction of the being's anatomy, the computer-readable reconstruction of the being's anatomy having a first updatable orientation, wherein the first updatable orientation is updated in response to the at least one signal; accessing a computer-readable reconstruction of an implant having a second updatable orientation; detecting a location of a pointer tool comprising a trackable element with the detector, the detector further configured to provide at least one other signal corresponding to a detected location of at least the pointer tool, wherein the pointer tool is associated with a location of an anatomical feature of interest; accessing at least one computer-readable reconstruction of a trace, the trace corresponding to a geometry of the anatomical feature of interest based on updated detected locations of the pointer tool; superimposing the at least one updatable, computer-readable trace on the second computer-readable reconstruction of the implant.. ... The Johns Hopkins University

09/21/17 / #20170271647

High energy density li-ion battery electrode materials and cells

A method of preparing a high capacity nanocomposite cathode of fef3 in carbon pores may include preparing a nanoporous carbon precursor, employing electrochemistry or solution chemistry deposition to deposit fe particles in the carbon pores, reacting nano fe with liquid hydrofluoric acid to form nano fef3 in carbon, and milling to achieve a desired particle size.. . ... The Johns Hopkins University

09/21/17 / #20170269174

System and method for real-time mri-guided object navigation

A magnetic resonance method and system are provided for magnetic resonance (mr) image-guided insertion of an object into a biological tissue along a predetermined trajectory. The trajectory provides a path between a starting point and a target site within the tissue. ... The Johns Hopkins University

09/21/17 / #20170269106

Circulating pulmonary hypertension biomarker

Methods and kits for determining, predicting, or diagnosing pulmonary artery hypertension (pah) and for determining the efficacy of pah therapy using biomarkers are provided.. . ... The Johns Hopkins University

09/21/17 / #20170269075

Biomarkers predictive of lupus progression and uses thereof

Methods, systems and kits to detect and/or quantify lupus and disease progression in a subject having, or at risk of having, lupus are disclosed.. . ... The Johns Hopkins University

09/21/17 / #20170268063

Methods for identifying androgen receptor splice variants in subjects having castration resistant prostate cancer

Methods of the present disclosure provide for detection of mutations and splice variants of the androgen receptor using a non-invasive approach, rnaseq, for examining circulating tumor cells.. . ... The Johns Hopkins University

09/21/17 / #20170268059

Dna hypermethylation of promoters of target genes and clinical diagnosis and treatment of hpv related disease

The present invention provides arrays for gene loci that allow diagnosis of cervical cancer in patients who may be asymptomatic or have inconclusive pap smears or cytology, and allowing earlier diagnosis and treatment of the subject. The present invention also provides methods of determination of a global promoter dna methylation in a cervical tissue sample from a subject, using a variety of methods which can detect dna methylation. ... The Johns Hopkins University

09/21/17 / #20170267760

Checkpoint blockade and microsatellite instability

Blockade of immune checkpoints such as cytotoxic t-lymphocyte antigen-4 (ctla-4) and programmed death-1 (pd-1) shows promise in patients with cancer. Inhibitory antibodies directed at these receptors have been shown to break immune tolerance and promote anti-tumor immunity. ... The Johns Hopkins University

09/21/17 / #20170266232

Activation of marrow infiltrating lymphocytes in hypoxic alternating with normoxic conditions

In some aspects, the invention relates to compositions comprising marrow infiltrating lymphocytes (“mils”). The mils may be activated mils. ... The Johns Hopkins University

09/21/17 / #20170266120

Nanocrystals, compositions, and methods that aid particle transport in mucus

Nanocrystals, compositions, and methods that aid particle transport in mucus are provided. In some embodiments, the compositions and methods involve making mucus-penetrating particles (mpp) without any polymeric carriers, or with minimal use of polymeric carriers. ... The Johns Hopkins University

09/14/17 / #20170261497

Reagents and methods for engaging unique clonotypic lymphocyte receptors

Platforms comprising at least one lymphocyte affecting molecule and at least one molecular complex that, when bound to an antigen, engages a unique clonotypic lymphocyte receptor can be used to induce and expand therapeutically useful numbers of specific lymphocyte populations. Antigen presenting platforms comprising a t cell affecting molecule and an antigen presenting complex can induce and expand antigen-specific t cells in the presence of relevant peptides, providing reproducible and economical methods for generating therapeutic numbers of such cells. ... The Johns Hopkins University

09/14/17 / #20170259083

Method and apparatus for determining treatment region and mitigating radiation toxicity

An apparatus for determining a contour of a treatment region in a patient includes a computer processor to receive input regarding a contour of at least one organ-at-risk (oar) adjacent to the treatment region; receive input regarding an initial contour of the treatment region; predict a radiation toxicity to the at least one oar based on the contour of the at least one oar, the initial contour of the treatment region, and a radiation treatment regimen; determine whether the predicted radiation toxicity exceeds a threshold; and determine a contour of the treatment region by iteratively modifying the initial contour of the treatment region, and any subsequent modified contours of the treatment region, until a stopping condition is satisfied. The stopping condition can be a preselected number of iterations or that the predicted radiation toxicity using the contour in place of the initial contour is first calculated is below said threshold.. ... The Johns Hopkins University

09/14/17 / #20170259082

Shape based initialization and qa of progressive auto-planning

A system and method for automatically generating radiation therapy treatment plans including one or more processors configured to capture geometries of organs at risk and a target volume specific to a subject, and use a shape-based algorithm to mine (152) a knowledgebase (38) of previously constructed treatment plans for similar geometries to the subject. The system and method interfaces (154) dosimetric information from a plan with a similar geometry as a patient specific starting point for a progressive tuning optimization algorithm resulting in fewer iterations. ... The Johns Hopkins University

09/14/17 / #20170258881

Annexin a2 as immunological target

Annexina2 (anxa2), a member of the annexin family of calcium-dependent, phospholipid binding proteins, is one of a panel of identified antigens recognized by the post-vaccination sera of patients who demonstrated prolonged disease-free survival following multiple vaccinations. Annexina2 is abundantly expressed in pancreatic adenocarcinomas and cell surface/membrane annexina2 increases with the progression from premalignant lesions to invasive pancreatic adenocarcinomas. ... The Johns Hopkins University

09/14/17 / #20170258838

Activation of marrow infiltrating lymphocytes in hypoxic alternating with normoxic conditions

In some aspects, the invention relates to compositions comprising marrow infiltrating lymphocytes (“mils”). The mils may be activated mils. ... The Johns Hopkins University

09/07/17 / #20170252169

A cutting machine for resizing raw implants during surgery

Provided is a method for forming an implant with an autonomous manufacturing device. The method includes accessing a first computer-readable reconstruction of a being's anatomy; accessing a second computer-readable reconstruction of an implant; accessing a third computer-readable reconstruction comprising the first computer-readable reconstruction superimposed with the second computer readable reconstruction; generating at least one computer-readable trace from a point cloud; and forming an implant with an autonomous manufacturing device, wherein the autonomous manufacturing device forms the implant into a shape defined by at least one dimension of the computer-readable trace.. ... The Johns Hopkins University

09/07/17 / #20170252115

Rotating needle driver and apparatuses and methods related thereto

Featured is a medical instrument driver, a robotic apparatus embodying such a medical instrument driver and methods related thereto for inserting a medical instrument into tissue of a mammal (e.g., human). Such medical instruments include medical needles, biopsy needles, trocars, cutters and introducers. ... The Johns Hopkins University

09/07/17 / #20170251929

Novel device and method to measure ventricular arterial coupling and vascular performance

A device and method for analyzing of a disturbed pattern of pulse wave front results in a non-invasive, real-time diagnostic tool of arterial vascular performance on both a global and regional scale. The device provides a single number quantifying how well the arterial tree as a whole is coupled to receive and distribute a stroke volume of a single heartbeat. ... The Johns Hopkins University

08/31/17 / #20170248666

Magnetic resonance imaging coil with adjustable opening

A configurable coil arrangement for use with mri-guided procedures is provided that facilitates optimal imaging for both pre-procedure planning and imaging of the target sites during the procedure. The coil arrangement includes a plurality of connected coil elements. ... The Johns Hopkins University

08/31/17 / #20170246320

Mucus penetrating gene carriers

Nanoparticles gene carriers, particularly nanoparticle gene carriers which exhibit increased rates of diffusion through cystic fibrosis (cf) mucus, as well as methods of making and using thereof, are described herein. The nanoparticle gene carriers are formed from a nucleic acid complexed to one or more biocompatible, polycationic polymers. ... The Johns Hopkins University








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