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The Johns Hopkins University patents


Recent patent applications related to The Johns Hopkins University. The Johns Hopkins University is listed as an Agent/Assignee. Note: The Johns Hopkins University may have other listings under different names/spellings. We're not affiliated with The Johns Hopkins University, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "T" | The Johns Hopkins University-related inventors


 new patent  Cyclodextrin compositions encapsulating a selective atp inhibitor and uses thereof

The invention provides compositions comprising cyclodextrins encapsulating a selective ATP inhibitor, as well as uses thereof.... The Johns Hopkins University

 new patent  Albumin-proaerolysin prodrugs

The present invention relates to the field of cancer. More specifically, the present invention provides compositions and methods for treating cancer using albumin-proaerolysin prodrugs. Accordingly, in one aspect, the present invention provides prodrug compositions. In certain embodiments, a prodrug composition comprises a prostate-specific antigen (PSA)-activated pro-aerolysin (PA), wherein a PSA... The Johns Hopkins University

 new patent  Compositions for the sustained release of anti-glaucoma agents to control intraocular pressure

Controlled release dosage formulations for the delivery of active agents, especially for treatment of eye diseases or disorders, such as glaucoma, have been developed. These provide release of the active agent, such as ECA or a derivative thereof, for an effective period of time.... The Johns Hopkins University

 new patent  Psma targeted fluorescent agents for image guided surgery

... The Johns Hopkins University

 new patent  Pharmacological modulators of gabaa receptors and their use

The present invention provides polypeptides and their variants and derivatives which modulate GABAA receptor function at nanomolar quantities by binding to the α+/β− subunit interface, as well as methods of making and using the same. The inventive peptides are useful for the study of neurological disease and function and can... The Johns Hopkins University

 new patent  Methods for characterizing and treating cognitive impairment in aging and disease

This invention provides methods for identifying genes associated with cognitive impairment and for identifying compounds useful in the treatment of cognitive impairment. The methods can in particular be used to identify genes associated with, and compounds useful in treating, cognitive impairment in aging.... The Johns Hopkins University

Delta mechanism with enhanced torsional stiffness

A mechanical translation apparatus includes a translation stage and a translation assembly operatively connected to the translation stage so as to impart linear motions to the translation stage substantially free of rotational motions. The translation assembly includes a plurality of at least three arms pivotably connected to the translation stage... The Johns Hopkins University

Hydrogels and use thereof in anastomosis procedures

This disclosure provides novel hydrogels that can undergo multiple gel-sol transitions and methods of making and using such hydrogels, particularly in anastomosis procedures. The peptide hydrogels comprising a fibrillar network of peptides that are in an amphiphilic β-hairpin conformation. The peptides comprise photo-caged glutamate residues with a neutral photocage that... The Johns Hopkins University

Method for optimizing radiation beam intensity profile shape using dual multiple aperture devices

The present invention is directed to multiple aperture devices (MADs) for beam shaping in x-ray imaging. Two or more of these binary filters can be placed in an x-ray beam in series to permit a large number of x-ray fluence profiles. However, the relationship between particular MAD designs and the... The Johns Hopkins University

Surface plasmon resonance approach to monitor protein-ligand interactions

The present invention provides assays utilizing SPR to detect protein-ligand interactions as well as compositions utilized is such assays.... The Johns Hopkins University

Endoscopic gastric mucosal ablation/resection/exclusion (a/r/e) as a minimally invasive weight loss approach

The present invention is directed to a method of endoscopically ablating/resecting/excluding (A/R/E) the mucosa of the gastric fundus and body. The method of the present invention is intended to cause cellular death to the X/A-like, ghrelin producing and other hormone cells. This is in contrast to present methods to provide... The Johns Hopkins University

Combination therapy for tuberculosis

The present invention relates to methods of treating tuberculosis, including multidrug resistant varieties and latent tuberculosis. More particularly, the present invention relates to a method of treating tuberculosis in a mammal comprising administering to said mammal in need thereof an effective amount of a compound of formula (T), (S)—N-[[3-[3-fluoro-4-(4-thiomor-pholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]acetamide, or... The Johns Hopkins University

Pre-curved steerable catheter with pull-wires for dexterous deflection control

A pre-curved steerable catheter includes a catheter body (102) having a distal end portion. The distal end portion includes a permanently curved flexible end portion (110). A pull wire (108) is disposed in a pull wire lumen within the catheter body. The pull wire extends from the distal end portion... The Johns Hopkins University

Systems and methods for separating metallic and nonmetallic particles in a mixed-particle suspension

A continuous flow particle separation system for separating metallic and nonmetallic particles from a mixed-particle suspension includes a fluid channeling component defining an input channel and first and second output channels fluidly connected to the input channel at a bifurcated junction, a first electrode and a second electrode arranged proximate... The Johns Hopkins University

Systems and methods for genome modification and regulation

The present invention provides methods of systems and methods of site specific methylation.... The Johns Hopkins University

Citrullinated brain and neurological proteins as biomarkers of brain injury or neurodegeneration

The present invention relates to the field of biomarkers. More specifically, the present invention relates to biomarkers useful in diagnosing brain injury or neurodegeneration. In one embodiment, a method for diagnosing brain injury in a patient comprises the steps of (a) obtaining a sample from the patient; (b) determining the... The Johns Hopkins University

Biomarkers useful in the treatment of subjects having disease of the eye

The present invention provides biomarkers of oxidative stress in subjects with retinitis pigmentosa, age-related macular degeneration, diabetic retinopathy, Fuchs' dystrophy, diabetic macular edema (DME), geographic atrophy, Stargardt's disease, or retinal vein occlusion (RVO), and their use in identifying subjects in need of treatment and methods for staging the severity of... The Johns Hopkins University

Battery internal temperature sensing battery management system

A method is provided. The method is executable by a processor of a battery management system. The method includes sending a first command signal to a multiplexer to cause the multiplexer to select a cell of a battery. The method also includes sending a second command signal to a current... The Johns Hopkins University

Sunitinib formulations and methods for use thereof in treatment of glaucoma

Methods for increasing the encapsulation or incorporation of Sunitinib into polymeric matrices have been developed. The resulting formulations provide for more sustained controlled release of sunitinib or other inhibitors of JNK signaling, which bind to DLK. Increased loading is achieved using an alkaline solvent system. The pharmaceutical compositions can be... The Johns Hopkins University

Method and compositions for the prevention and treatment of a hiv infection

Described herein are methods of preventing or treating a HIV infection comprising administering to a mammal in need thereof, a pharmaceutically effective amount of a CD8+ T cell vaccine composition. Such methods comprising using CD8+ T cells which have been pre-stimulated with at least one HIV epitope, to thereby enhance... The Johns Hopkins University

Implantable body-driven shunt pump

An implantable, body-driven shunt pump includes a pump body defining a fluid inlet, a fluid outlet and a fluid chamber therebetween; an inlet valve arranged in the fluid inlet, the inlet valve being a one-way valve arranged such that it is operable to allow fluid flow into the fluid chamber... The Johns Hopkins University

System and conditioning of engineered tissues

A system and method for conditioning a tissue are provided. The system includes a substrate, a plurality of microwells formed in the substrate, and a microsphere associated with each of the plurality of microwells. The system also includes a pair of flexible pillars within each of the plurality of microwells.... The Johns Hopkins University

Recombinant aav production in mammalian cells

The present invention includes methods and compositions for the production of high titer recombinant Adeno-Associated Virus (rAAV) in a variety of mammalian cells. The disclosed rAAV are useful in gene therapy applications. Disclosed methods based on co-infection of cells with two or more replication-defective recombinant herpes virus (rHSV) vectors are... The Johns Hopkins University

Consensus coding sequences of human breast and colorectal cancers

Analysis of 13,023 genes in 11 breast and 11 colorectal cancers revealed that individual tumors accumulate an average of ˜90 mutant genes but that only a subset of these contribute to the neoplastic process. Using stringent criteria to delineate this subset, we identified 189 genes (average of 11 per tumor)... The Johns Hopkins University

Methods and compositions for treating or preventing pruritis

The invention features therapeutic compositions comprising agents useful for the treatment or prevention of pruritis, and methods useful for identifying such agents.... The Johns Hopkins University

Three dimensional woven lattices for drag reduction and turbulence reduction

The present invention is directed to three dimensional (3D) woven lattices for drag and turbulence reduction. 3D woven lattice material can serve as a surface layer that regularizes the flow around a bluff body with beneficial effects on: 1) drag reduction, 2) decrease in turbulence intensity, 3) attenuation of flow-induced... The Johns Hopkins University

Direct estimation of patient attributes based on mri brain atlases

The present invention is directed to a context-based image retrieval (CBIR) system for disease estimation based on the multi-atlas framework, in which the demographic and diagnostic information of multiple atlases are weighted and fused to generate an estimated diagnosis, on a structure-by-structure basis. The present invention demonstrates high accuracy in... The Johns Hopkins University

Methods and compositions for killing senescent cells and for treating senescence-associated diseases and disorders

Methods are provided herein for selectively killing senescent cells and for treating senescence-associated diseases and disorders by administering a senolytic agent. Senescence-associated diseases and disorders treatable by the methods using the senolytic agents described herein include cardiovascular diseases and disorders associated with or caused by arteriosclerosis, such as atherosclerosis; idiopathic... The Johns Hopkins University

Image-guided embryo transfer for in vitro fertilization

A method for performing image-guided embryo transfer for in vitro fertilization includes performing a pre-operative magnetic resonance imaging (MRI) scan of a subjects pelvic region to yield a first MRI image dataset. A computer applies a segmentation routine to the first MRI image dataset to yield segment data which is... The Johns Hopkins University

Compositions and methods for treating autism spectrum disorders

The instant disclosure features, among other things, compositions and methods for treating an autism spectrum disorder in a human. The compositions comprise an effective amount of: (1) an isothiocyanate (e.g., sulforaphane or a derivative thereof) or (2) a glucosinolate, and optionally, an enzyme, to thereby treat an autism spectrum disorder... The Johns Hopkins University

Methods of treatment using stem cell mobilizers

The present invention relates to the field of stem cells. In one aspect, the present invention provides methods of treating a subject with acute liver injury comprising administering to the subject a therapeutically effective amount of at least one stem cell mobilizer. In particular embodiments, the subject is treated with... The Johns Hopkins University

Chaotrope- and volatile-free purifying nucleic acids from plasma

The presently disclosed subject matter provides methods and kits for purifying nucleic acids from blood plasma using a functionalized solid phase comprising a silica or polymer backbone and non-chaotropic and ethanol-free buffers.... The Johns Hopkins University

Electrospinning aramid nanofibers

Example methods and articles of manufacture related to electrospun aramid nanofibers are provided. One example method may include forming a resultant solution by reacting a solution of aramids dissolved in a solvent with an electrophile. In this regard, the electrophile may perform a side chain substitution on the dissolved aramids.... The Johns Hopkins University

Treatment of retinitis pigmentosa with n-acetylcysteine amide

The present invention includes a method for the treatment of retinitis pigmentosa in a human that comprises adminisering to the human a therapeutically effective amount of N-acetylcysteine amide (NACA). In accordance with an embodiment, the present invention provides a method for the treatment of retinitis pigmentosa in an animal that... The Johns Hopkins University

New scaffolds and multifunctional intermediates for imaging psma and cancer therapy

Carbamate and beta-amino acid urea-based scaffolds that have high binding affinity to PSMA are disclosed. These scaffolds can be radiolabeled and used for imaging cells and tumors that express PSMA or for cancer radiotherapy. These compounds also can comprise a fluorescent dye and be used for imaging cells and tumors... The Johns Hopkins University

11/23/17 / #20170335442

Method for forming binder-free refractory carbide, nitride and boride coatings with a controlled porosity

The present invention is directed to methods for formation of refractory carbide, nitride, and boride coatings without use of a binding agent. The present invention is directed to methods of creating refractory coatings with controlled porosity. Refractory coatings can be formed from refractory metal, metal oxide, or metal/metal oxide composite... The Johns Hopkins University

11/23/17 / #20170336387

Aggregation-assisted separation of plasma from whole blood

Methods for separating blood plasma from whole blood in the absence of performing centrifugation are provided. The method combines mechanical filtration and blood cell aggregation and is adapted for use in POC clinical testing.... The Johns Hopkins University

11/23/17 / #20170336399

Novel methods and devices for high-throughput quantification, detection and temporal profiling of cellular secretions, and compositions identified using same

The present invention relates to the unexpected discovery of methods and devices that can be used for high-throughput precise quantification, detection and/or temporal profiling of cellular secretions. In various embodiments, the methods of the invention allow for high-throughput absolute detection of secretions of cells, identification of the nature of the... The Johns Hopkins University

11/16/17 / #20170326136

Treatment of pain

This disclosure provides a technology for managing the sensation of pain in a subject in need thereof. Treatment methods according to this invention include administering to the subject a formulation that contains an effective amount of (4-[(4S,5R)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-2-piperazinone).... The Johns Hopkins University

11/16/17 / #20170327543

Polyionic papilloma virus-like particle (vlp) vaccines

The present invention relates to the field of vaccines. In particular, the present invention provides compositions and methods relating to virus-like particle (VLP) vaccines. In one embodiment, a chimeric papillomavirus virus-like particle (VLP) comprises the L1 protein, wherein the HI loop of the L1 protein comprises negatively charged amino acids.... The Johns Hopkins University

11/16/17 / #20170327898

Ovarian carcinoma detection and prophylaxis

The evolutionary origin of high-grade serous ovarian carcinoma remains largely unknown. The vast majority of tumor-specific genomic alterations from ovarian cancers are present in fallopian tube STIC lesions (average of 55 sequence alterations per tumor), including those affecting TP53, BRCA1, BRCA2 or PTEN genes. A quantitative evolutionary analysis indicated that... The Johns Hopkins University

11/09/17 / #20170319278

Systems and methods for atrial fibrillation treatment and risk assessment

According to some embodiments of the invention, a method for providing an atrial fibrillation (AF) ablation treatment plan includes receiving imaging data for at least a portion of an atrial region of a subject's heart, and processing the imaging data to characterize tissue as one of fibrotic tissue or non-fibrotic... The Johns Hopkins University

11/09/17 / #20170323118

Apparatus and private information retrieval

Apparatuses and methods for private information retrieval are provided. One example method may include receiving a query state machine that is an encoding of a search pattern. The query state machine may include a plurality of states and a transition function that defines a plurality of transitions based on the... The Johns Hopkins University

11/02/17 / #20170311809

General b-mode surface imaging

An ultrasound system includes an ultrasound transducer, an ultrasound controller structured to communicate with the ultrasound transducer, and a signal processing system structured to communicate with the ultrasound transducer. The ultrasound controller is structured to provide control signals to the ultrasound transducer to transmit a plurality of at least three... The Johns Hopkins University

11/02/17 / #20170312547

Method to reconstruct the 3d map of the radiation treatment isocenter of a medical accelerator

For the delivery of high precision radiation treatment, the accuracy with which a target is irradiated at individual gantry, collimator and patient couch orientation is traditionally verified in 2D. With the QA device described herein, the coverage of the gantry is uniquely measured in 3D. The method of the present... The Johns Hopkins University

11/02/17 / #20170313775

Checkpoint blockade and microsatellite instability

Blockade of immune checkpoints such as cytotoxic T-lymphocyte antigen-4 (CTLA-4) and programmed death-1 (PD-1) shows promise in patients with cancer. Inhibitory antibodies directed at these receptors have been shown to break immune tolerance and promote anti-tumor immunity. These agents work particularly well in patients with a certain category of tumor.... The Johns Hopkins University

11/02/17 / #20170314080

Serum-based mirna microarray and its use in diagnosis and treatment of barrett's esophagus (be) and esophageal adenocarcinoma (eac)

Robust and reliable molecular diagnostic screening tools for early detection of esophageal and gastrointestinal tract cancers and pre-cancerous lesions, such as Barrett's Esophagus, and esophageal adenocarcinoma are provided. Included in the invention is an array of miRNA probes specific for identifying, diagnosing and prognosticating esophageal and gastrointestinal tract cancers and... The Johns Hopkins University

11/02/17 / #20170315135

Biomarkers useful in the treatment of subjects having retinits pigmentosa

The present invention provides biomarkers of oxidative stress in subjects with Retinitis Pigmentosa and their use in identifying subjects in need of treatment and methods for staging the severity of the disease.... The Johns Hopkins University

11/02/17 / #20170315138

Assay reagents for a neurogranin diagnostic kit

The present invention relates to the field of biomarkers. More specifically, the present invention relates to assay reagents useful in detecting neurogranin. In a specific embodiment, the present invention provides an isolated antibody or fragment thereof that specifically binds to neurogranin. In another embodiment, the present invention provides a polynucleotide... The Johns Hopkins University

10/26/17 / #20170304214

Therapeutic electrospun fiber compositions

The instant invention provides electrospun fiber compositions comprising one or more polymers and one or more biologically active agents. In specific embodiments, the biologically active agents are nerve growth factors. In certain embodiments, the electrospun fiber compositions comprising one or more biologically active agents are on the surface of a... The Johns Hopkins University

10/26/17 / #20170305847

N-hydroxylsulfonamide derivatives as new physiologically useful nitroxyl donors

The invention relates to N-hydroxysulfonamide derivatives that donate nitroxyl (HNO) under physiological conditions and are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure and ischemia/reperfusion injury. Novel N-hydroxysulfonamide derivatives release NHO at a controlled rate under... The Johns Hopkins University

10/26/17 / #20170305990

Tmem100 peptides and variants thereof and their use in treating or preventing diseases or conditions

The present invention features compositions of Tmem100 peptides and variants thereof, and their use in treating or preventing diseases or conditions.... The Johns Hopkins University

10/26/17 / #20170311101

Middle ear implant sensor

A middle ear implant may include a first interface portion configured to interface with a first structure of a middle ear of a patient, a second interface portion configured to interface with a second structure of the middle ear of the patient, a shaft configured to connect the first interface... The Johns Hopkins University

10/19/17 / #20170296193

Biodegradable nerve guides

The present invention is directed to the compositions and methods of preparing hydrogel-grafted nerve guides for peripheral nerve regeneration. Particularly, the present invention describes the nerve guides and methods for preparation of hydrogel-grafted nerve guides with encapsulated neurotrophic factors and a nanofiber mesh lining the inner surface of the guide.... The Johns Hopkins University

10/19/17 / #20170296682

Derivatives of dibenzothiophene imaging of alpha-7 nicotinic acetylcholine receptors

The presently disclosed subject matter provides non-invasive methods for imaging, quantifying α7 nicotinic cholinergic receptors, and diagnosing a disease or condition associated with α7-nAChRs. Methods for preparing radiolabeled derivatives of dibenzothiophene and compounds provided thereof also are provided.... The Johns Hopkins University

10/12/17 / #20170291030

System and brain stimulation for improvement of motor symptoms in parkinson's disease and other movement disorders

An embodiment in accordance with the present invention is directed to a system and device for applying electrical direct current transcranially to the brain that is combined with a behavioral activity consisting of an isometric force production task. The device is non-invasive or implantable and serves to improve motor symptoms... The Johns Hopkins University

10/12/17 / #20170292963

Biomarkers of cognitive dysfunction

The present invention relates to the field of cognitive function. More specifically, the present invention provides compositions and methods useful for assessing cognitive dysfunction/function in Alzheimer's disease and other diseases of cognition. In one embodiment, the method comprises the steps of (a) reducing heterocomplexes comprising NPTX1 and NPTX2 present in... The Johns Hopkins University

10/12/17 / #20170293008

Measurement of blood volume using velocity-selective pulse trains on mri

The present invention is directed to a system and method for measuring blood volume using non-contrast-enhanced magnetic resonance imaging. The method of the present invention includes a subtraction-based method using a pair of acquisitions immediately following velocity-sensitized pulse trains for the label module and its corresponding control module, respectively. The... The Johns Hopkins University

10/12/17 / #20170295337

Flexible readout and signal processing in a computational sensor array

A computational sensing array includes an array of sensing elements. In each sensing element, a first signal is generated from a transducer. A second signal is produced by a collection unit in response to receiving the first signal. The second signal may be modified, in a conditioning unit. A sensing... The Johns Hopkins University

10/05/17 / #20170280730

Compositions and methods useful for the prevention of malaria and dengue virus transmission

The present invention relates to the fields of malaria and dengue virus. More specifically, the present invention provides compositions and methods useful for the treatment and prevention of malaria and dengue virus. In particular embodiments, a composition comprises mosquito nectar feed and Chromobacterium sp_Panamam (Csp_P).... The Johns Hopkins University

10/05/17 / #20170281463

Ecg artifact reduction system

An ECG signal processing system which removes the CPR-induced artifact from measured ECG signals obtained during the administration of CPR.... The Johns Hopkins University

10/05/17 / #20170281541

Liposome-based mucus-penetrating particles for mucosal delivery

Liposome-based mucus-penetrating particles (MPP) capable of loading hydrophilic agents including therapeutic, prophylactic and diagnostic agents such as the diaCEST MRI contrast agent barbituric acid (BA) were evaluated to determine how to optimize delivery. Polyethylene glycol (PEG)-coated liposomes containing ≧7 mol % PEG diffused only approximately 10-fold slower in human cervicovaginal... The Johns Hopkins University

10/05/17 / #20170281579

Compositions and methods for treating refractory seizures

The present invention relates to the field of seizures. More specifically, the present invention provides compositions and methods for treating refractory seizures in neonates. In one embodiment, the method comprises the steps of (a) administering to the patient an amount of a KCC2 agonist and/or trkB antagonist effective to restore... The Johns Hopkins University

10/05/17 / #20170283384

Psma targeted fluorescent agents for image guided surgery

Compositions and methods for visualizing tissue under illumination with near-infrared radiation, including compounds comprising near-infrared, closed chain, sulfo-cyanine dyes and prostate specific membrane antigen ligands are disclosed.... The Johns Hopkins University

10/05/17 / #20170288114

Thermoelectric polymer composites

An embodiment of the present disclosure is directed to a thermoelectric polymer composite. The composite comprises: at least one polymer selected from semiconducting polymers and conducting polymers; and at least one particle inclusion having one or more dimensions of 1 millimeter or less and at least one dimension of 10... The Johns Hopkins University

Patent Packs
09/28/17 / #20170273797

Computer-assisted cranioplasty

Provided is a surgical method. The method includes detecting a location of a reference unit having a trackable element with a detector, the detector configured to provide at least one signal corresponding to a detected location of at least the reference unit's trackable element, wherein the reference unit is associated... The Johns Hopkins University

09/28/17 / #20170273901

Sunitinib formulations and methods for use thereof in treatment of ocular disorders

Methods for increasing the encapsulation or incorporation of Sunitinib into polymeric matrices have been developed. The resulting formulations provide for more sustained controlled release of sunitinib or its analog or a pharmaceutically acceptable salt thereof. Increased loading is achieved using an alkaline solvent system. The pharmaceutical compositions can be administered... The Johns Hopkins University

09/28/17 / #20170274102

Post-surgical imaging marker

A marker for imaging includes a bio-dissolvable material and a contrast agent configured to provide contrast during an imaging procedure. A method can include forming a marker for imaging from a bio-dissolvable material and impregnating the bio-dissolvable material with a contrast agent. A method can include implanting a bio-dissolvable marker... The Johns Hopkins University

09/28/17 / #20170275673

Methods and compositions related to prostate cancer therapeutics

Disclosed herein are compositions and methods for detecting biological molecules and biomarkers associated with prostate cancer. Disclosed herein are compositions and methods for detecting biological molecules and biomarkers associated with castration-resistant prostate cancer wherein such biological molecules and biomarkers comprise androgen-receptor splice variants that can be used to develop effective... The Johns Hopkins University

09/28/17 / #20170275705

Biomarkers useful for determining response to pd-1 blockade therapy

PD-L1 expression by tumor cells prior to treatment correlates highly with response to anti-PD-1 and anti-PD-L1 therapy (e.g., nivolumab (Bristol-Myers Squibb), pembrolizumab (Merck)) and anti-PD-L1 monotherapy (MPDL3280A (Genentech/Roche)). Nonetheless, the majority of patients with PD-LI(+) tumors do not respond to PD-1 pathway blockade. Distinct gene profiles associated with differential response... The Johns Hopkins University

09/28/17 / #20170276669

Precise estimation of glomerular filtration rate from multiple biomarkers

The present invention relates to the field of nephrology. More specifically, the present invention provides methods and compositions useful for more precisely estimating glomerular filtration rate (GFR). In a specific embodiment, a method for calculating the estimated glomerular filtration rate (eGFR) in a patient comprises the steps of (a) measuring... The Johns Hopkins University

09/28/17 / #20170276687

Compositions and methods for detecting anti-endothelial cell antibodies in allograft rejection

Provided herein are methods, compositions, and kits for diagnosing allograft rejection of organ transplants by identifying the presence of anti-endothelial cell antibodies. Such methods and compositions are independent of external confounders such as recipient age, transplant center, assay, cause of end-stage disease, co-morbidities, immunosuppression usage, and the like.... The Johns Hopkins University

09/28/17 / #20170276688

Anti-himf antibodies to treat lung diseases

Hypoxia induced mitogenic factor (HIMF) is a member of the “found in inflammatory zone” (FIZZ)/resistin family of proteins and has potent mitogenic, angiogenic, and vasoconstrictive effects in the lung vasculature. The receptor/binding partners for this family of proteins have been largely unknown. We identified Bruton's tyrosine kinase (BTK) as a... The Johns Hopkins University

09/28/17 / #20170276742

Sterile rf coils for mr imaging systems

Sterile RF coil arrangements for use in magnetic resonance imaging are provided. The sterile coil arrangements can be formed by spraying or coating a curable liquid onto an RF coil housing and allowing the liquid to cure or dry to form a continuous sterile layer on the coil housing. The... The Johns Hopkins University

09/21/17 / #20170266120

Nanocrystals, compositions, and methods that aid particle transport in mucus

Nanocrystals, compositions, and methods that aid particle transport in mucus are provided. In some embodiments, the compositions and methods involve making mucus-penetrating particles (MPP) without any polymeric carriers, or with minimal use of polymeric carriers. The compositions and methods may include, in some embodiments, modifying the surface coatings of particles... The Johns Hopkins University

09/21/17 / #20170266232

Activation of marrow infiltrating lymphocytes in hypoxic alternating with normoxic conditions

In some aspects, the invention relates to compositions comprising marrow infiltrating lymphocytes (“MILs”). The MILs may be activated MILs. In some aspects, the invention relates to methods for activating MILs, comprising incubating MILs in an environment comprising less than 21% oxygen. In some aspects, the invention relates to methods for... The Johns Hopkins University

09/21/17 / #20170267760

Checkpoint blockade and microsatellite instability

Blockade of immune checkpoints such as cytotoxic T-lymphocyte antigen-4 (CTLA-4) and programmed death-1 (PD-1) shows promise in patients with cancer. Inhibitory antibodies directed at these receptors have been shown to break immune tolerance and promote anti-tumor immunity. These agents work particularly well in patients with a certain category of tumor.... The Johns Hopkins University

09/21/17 / #20170268059

Dna hypermethylation of promoters of target genes and clinical diagnosis and treatment of hpv related disease

The present invention provides arrays for gene loci that allow diagnosis of cervical cancer in patients who may be asymptomatic or have inconclusive Pap smears or cytology, and allowing earlier diagnosis and treatment of the subject. The present invention also provides methods of determination of a global promoter DNA methylation... The Johns Hopkins University

09/21/17 / #20170268063

Methods for identifying androgen receptor splice variants in subjects having castration resistant prostate cancer

Methods of the present disclosure provide for detection of mutations and splice variants of the androgen receptor using a non-invasive approach, RNAseq, for examining circulating tumor cells.... The Johns Hopkins University

09/21/17 / #20170269075

Biomarkers predictive of lupus progression and uses thereof

Methods, systems and kits to detect and/or quantify lupus and disease progression in a subject having, or at risk of having, lupus are disclosed.... The Johns Hopkins University

Patent Packs
09/21/17 / #20170269106

Circulating pulmonary hypertension biomarker

Methods and kits for determining, predicting, or diagnosing pulmonary artery hypertension (PAH) and for determining the efficacy of PAH therapy using biomarkers are provided.... The Johns Hopkins University

09/21/17 / #20170269174

System and real-time mri-guided object navigation

A magnetic resonance method and system are provided for magnetic resonance (MR) image-guided insertion of an object into a biological tissue along a predetermined trajectory. The trajectory provides a path between a starting point and a target site within the tissue. Sufficiently high resolution images can be generated in real... The Johns Hopkins University

09/21/17 / #20170271647

High energy density li-ion battery electrode materials and cells

A method of preparing a high capacity nanocomposite cathode of FeF3 in carbon pores may include preparing a nanoporous carbon precursor, employing electrochemistry or solution chemistry deposition to deposit Fe particles in the carbon pores, reacting nano Fe with liquid hydrofluoric acid to form nano FeF3 in carbon, and milling... The Johns Hopkins University

09/14/17 / #20170258838

Activation of marrow infiltrating lymphocytes in hypoxic alternating with normoxic conditions

In some aspects, the invention relates to compositions comprising marrow infiltrating lymphocytes (“MILs”). The MILs may be activated MILs. In some aspects, the invention relates to methods for activating MILs, comprising incubating MILs in an environment comprising less than 21% oxygen. In some aspects, the invention relates to methods for... The Johns Hopkins University

09/14/17 / #20170258881

Annexin a2 as immunological target

AnnexinA2 (ANXA2), a member of the Annexin family of calcium-dependent, phospholipid binding proteins, is one of a panel of identified antigens recognized by the post-vaccination sera of patients who demonstrated prolonged disease-free survival following multiple vaccinations. AnnexinA2 is abundantly expressed in pancreatic adenocarcinomas and cell surface/membrane AnnexinA2 increases with the... The Johns Hopkins University

09/14/17 / #20170259082

Shape based initialization and qa of progressive auto-planning

A system and method for automatically generating radiation therapy treatment plans including one or more processors configured to capture geometries of organs at risk and a target volume specific to a subject, and use a shape-based algorithm to mine (152) a knowledgebase (38) of previously constructed treatment plans for similar... The Johns Hopkins University

09/14/17 / #20170259083

Method and determining treatment region and mitigating radiation toxicity

An apparatus for determining a contour of a treatment region in a patient includes a computer processor to receive input regarding a contour of at least one organ-at-risk (OAR) adjacent to the treatment region; receive input regarding an initial contour of the treatment region; predict a radiation toxicity to the... The Johns Hopkins University

09/14/17 / #20170261497

Reagents and methods for engaging unique clonotypic lymphocyte receptors

Platforms comprising at least one lymphocyte affecting molecule and at least one molecular complex that, when bound to an antigen, engages a unique clonotypic lymphocyte receptor can be used to induce and expand therapeutically useful numbers of specific lymphocyte populations. Antigen presenting platforms comprising a T cell affecting molecule and... The Johns Hopkins University

09/14/17 / #20170261527

System and screening a library of samples

... The Johns Hopkins University

09/07/17 / #20170251929

Novel device and method to measure ventricular arterial coupling and vascular performance

A device and method for analyzing of a disturbed pattern of pulse wave front results in a non-invasive, real-time diagnostic tool of arterial vascular performance on both a global and regional scale. The device provides a single number quantifying how well the arterial tree as a whole is coupled to... The Johns Hopkins University

09/07/17 / #20170252115

Rotating needle driver and apparatuses and methods related thereto

Featured is a medical instrument driver, a robotic apparatus embodying such a medical instrument driver and methods related thereto for inserting a medical instrument into tissue of a mammal (e.g., human). Such medical instruments include medical needles, biopsy needles, trocars, cutters and introducers. Such a medical instrument driver according to... The Johns Hopkins University

09/07/17 / #20170252169

A cutting machine for resizing raw implants during surgery

Provided is a method for forming an implant with an autonomous manufacturing device. The method includes accessing a first computer-readable reconstruction of a being's anatomy; accessing a second computer-readable reconstruction of an implant; accessing a third computer-readable reconstruction comprising the first computer-readable reconstruction superimposed with the second computer readable reconstruction;... The Johns Hopkins University

09/07/17 / #20170252310
08/31/17 / #20170245976

Implantable bioreactor for delivery of paracrine factors

An implantable bioreactor containing a barrier which is designed to allow the release of cell-derived biomolecules, but restricts the entry of immunologic and other cells, or the egress of the cells contained within the bioreactor. Two broad classes of implantable bioreactors are envisioned, encompassing devices for both systemic delivery of... The Johns Hopkins University

08/31/17 / #20170246079

Automated chest compression apparatus

A system applies cardiopulmonary resuscitation (CPR) to a recipient. An automated controller is provided together with a compression device which periodically applies a force to a recipient's thorax under control of the automated controller. A band is adapted to be placed around a portion of the torso of the recipient... The Johns Hopkins University

08/31/17 / #20170246277

Reagents and methods for identifying, enriching, and/or expanding antigen-specific t cells

Antigen-specific T cells, including nave T cells, and including rare precursor cells are enriched and expanded in culture. Enrichment and expansion provides a platform for more effective immunotherapy by adoptive transfer, as well as platforms for personalizing immunotherapy by determining T cell reactivity with a library of candidate peptide antigens.... The Johns Hopkins University

08/31/17 / #20170246320

Mucus penetrating gene carriers

Nanoparticles gene carriers, particularly nanoparticle gene carriers which exhibit increased rates of diffusion through cystic fibrosis (CF) mucus, as well as methods of making and using thereof, are described herein. The nanoparticle gene carriers are formed from a nucleic acid complexed to one or more biocompatible, polycationic polymers. The nanoparticle... The Johns Hopkins University

08/31/17 / #20170248666

Magnetic resonance imaging coil with adjustable opening

A configurable coil arrangement for use with MRI-guided procedures is provided that facilitates optimal imaging for both pre-procedure planning and imaging of the target sites during the procedure. The coil arrangement includes a plurality of connected coil elements. Spacers connecting the coil elements can be adjustable and/or deformable to provide... The Johns Hopkins University

08/24/17 / #20170238897

Self-calibrating projection geometry for volumetric image reconstruction

The present invention is directed to a method for enabling volumetric image reconstruction from unknown projection geometry of tomographic imaging systems, including CT, cone-beam CT (CBCT), and tomosynthesis systems. The invention enables image reconstruction in cases where it was not previously possible (e.g., custom-designed trajectories on robotic C-arms, or systems... The Johns Hopkins University

08/24/17 / #20170240421

Method of carbon dioxide-free hydrogen production from hydrocarbon decomposition over metal salts

A process to decompose methane into carbon (graphitic powder) and hydrogen (H2 gas) without secondary production of carbon dioxide, employing a cycle in which a secondary chemical is recycled and reused, is disclosed.... The Johns Hopkins University

08/24/17 / #20170242973

E-triage: an electronic emergency triage system

An embodiment in accordance with the present invention provides a system that uses simple standardized patient information routinely collected at triage to distribute patients amongst triage levels based on critical and time-sensitive outcomes. The present invention estimates the probability of electronic medical record (EMR) recorded events for patients at triage.... The Johns Hopkins University








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