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The Penn State Research Foundation
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The Penn State Research Foundation patents


Recent patent applications related to The Penn State Research Foundation. The Penn State Research Foundation is listed as an Agent/Assignee. Note: The Penn State Research Foundation may have other listings under different names/spellings. We're not affiliated with The Penn State Research Foundation, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "T" | The Penn State Research Foundation-related inventors


 new patent  Identifying visual storm signatures from satellite images

Satellite images from vast historical archives are analyzed to predict severe storms. We extract and summarize important visual storm evidence from satellite image sequences in a way similar to how meteorologists interpret these images. The method extracts and fits local cloud motions from image sequences to model the storm-related cloud... The Penn State Research Foundation

Tracheal protective neonatal ventilation device

The present invention relates to a tracheal protective ventilation device specially adapted for use with neonates, a stylet that aids in insertion and spatial verification of the tracheal protective ventilation device, and methods for using the same. The ventilation provided by the devices of the present invention is atraumatic to... The Penn State Research Foundation

Processes and treatment systems for treating high phosphorous containing fluids

Disclosed herein are processes for treating high-P fluid involving (1) providing a high-P containing stream; (2) chemically treating the high-P stream such that a majority of dissolved P in the stream is transformed into a solid form via sorption of P onto particles placed or precipitated within the stream; and... The Penn State Research Foundation

Gene construct encoding mutant thioesterase, mutant thioesterase encoded thereby, transformed host cell containing the gene construct, and using them to produce medium-chain fatty acids

Unnatural, mutated thioesterases having an amino acid sequence that is at least 80% identical to SEQ. ID. NO: 1 and having substitutions at one or more of amino acid positions I107, R108, L109, S122, M141, E142, Y145, and L146, gene constructs encoding and configured to express the mutated thioesterases in... The Penn State Research Foundation

Medical food for the treatment of malaria and/or iron deficiency

The present invention encompasses compositions and methods for treating or preventing malaria, compositions and methods for treating or preventing iron deficiency, and compositions and methods for simultaneously treating or preventing malaria and iron deficiency.... The Penn State Research Foundation

Thermal barrier coatings

High temperature stable thermal barrier coatings useful for substrates that form component parts of engines such as a component from a gas turbine engine exposed to high temperatures are provided. The thermal barrier coatings include a multiphase composite and/or a multilayer coating comprised of two or more phases with at... The Penn State Research Foundation

Chemical reprogramming of human glial cells into neurons for brain and spinal cord repair

Provided are methods and compositions from reprogramming human glial cells into human neurons. The reprogramming is achieved using combinations of compounds that can modify signaling via Transforming growth factor beta (TGF-β), Bone morphogenetic protein (BMP), glycogen synthase kinase 3 (GSK-3), and γ-secretase/Notch pathways. The reprogramming is demonstrated using groups of... The Penn State Research Foundation

Systems and methods for detection of significant and attractive components in digital images

Systems, methods, and computer-readable media for electronically assessing a visual significance of pixels or regions in an electronic image are disclosed. A method includes receiving the electronic image, performing a composition analysis on the electronic image, the composition analysis includes partitioning the electronic image into a plurality of segments or... The Penn State Research Foundation

Low power sense amplifier based on phase transition material

A sense amplifier utilizes a phase transition material (PTM) in conjunction with CMOS circuits to provide a precise sensing threshold. The sense amplifier can be used in memory applications to sense states of stored bits with high accuracy and robustness. In one sense amplifier, a first diode-connected transistor has gate... The Penn State Research Foundation

Medical image reporting system and method

This invention relates generally to medical imaging and, in particular, to a method and system for automatic lymph node station mapping, automatic path or route report generation. A computer-based system for automatically locating the central chest lymph-node stations in a 3D MDCT image is described. Automated analysis methods extract the... The Penn State Research Foundation

Modulators of acyl-coa lysocardiolipin acyltransferase 1 (alcat1) and uses thereof

Compositions of modulators of acyl-CoA lysocardiolipin acyltransferase 1 (ALCAT1) expression, function or activity are provided. In particular, inhibitors of ALCAT1 are useful in treating metabolic diseases, cardiac diseases and, in general diseases associated with mitochondrial dysfunction. Assays for identification of novel ALCAT1 modulators are provided.... The Penn State Research Foundation

Regenerating functional neurons for treatment of disease and injury in the nervous system

Methods for producing new neurons in the brain in vivo are provided according to aspects of the present invention which include introducing NeuroD1 into a glial cell, particularly into a reactive astrocyte or NG2 cell, thereby “converting” the reactive glial cell to a neuron. Methods of producing a neuronal phenotype... The Penn State Research Foundation

Percutaneous heart pump

Disclosed herein are heart pumps that can include a catheter body and an impeller coupled with a distal end of the catheter body. The impeller can include a tip that is resealable or that includes a resealable member. The heart pump can also include a diffuser disposed between the distal... The Penn State Research Foundation

Heart assist device with expandable impeller pump

An impeller includes a hub and a blade supported by the hub. The impeller has a stored configuration in which the blade is compressed so that its distal end moves towards the hub, and a deployed configuration in which the blade extends away from the hub. The impeller may be... The Penn State Research Foundation

Bioconjugation of calcium phosphosilicate nanoparticles for selective targeting of cells in vivo

Non-aggregating resorbable calcium phosphosilicate nanoparticles (CPNPs) are bioconjugated to targeting molecules that are specific for particular cells. The CPNPs are stable particles at normal physiological pH. Chemotherapy and imaging agents may be integrally formed with the CPNPs so that they are compartmentalized within the CPNPs. In this manner, the agents... The Penn State Research Foundation

Novel selenazolidine and thiazolidine compounds for treating cancer and other diseases

The present invention includes compounds useful in preventing or treating cancer in a subject in need thereof. The present invention also includes methods of preventing or treating cancer in a subject in need thereof by administering to the subject a therapeutically effective amount of a compound of the invention.... The Penn State Research Foundation

Carbon-based nanostructure membranes

The disclosure features methods for preparing a carbon nanostructure-based membranes, the methods including initiating self-assembly of a plurality of carbon nanostructures by suspending the nanostructures in a liquid where the liquid has a density that exceeds a density of the nanostructures, forming a membrane on a surface by removing the... The Penn State Research Foundation

Bone repair system and method

A bone repair system and method for percutaneously fixing a first bone segment to a second bone segment, such as rib bone segments, in a body of a patient include drilling a first hole through the first bone segment and a second hole through the second bone segment, and feeding... The Penn State Research Foundation

Functional peptide analogs of pedf

The invention provides compositions and methods relating to bioactive peptide analogs of PEDF.... The Penn State Research Foundation

Compositions and methods for prophylaxis and/or therapy of disorders that correlate with dennd1a variant 2

Pharmaceutical compositions and methods for the treatment of DENND1A.V2 related disorders, such as PCOS, are provided. In particular, humanized and mouse monoclonal antibodies specific for DENND1A.V2 and methods for using the same are provided.... The Penn State Research Foundation

Ammonia-based thermoelectrochemical systems and methods

Thermally regenerative ammonia-based battery systems and methods of their use to produce electricity are provided according to aspects described herein in which ammonia is added into an anolyte to charge the battery, producing potential between the electrodes. At the anode, metal corrosion occurs in the ammonia solution to form an... The Penn State Research Foundation

Nanofilled solid polymer electrolytes

Embodiments of the disclosure relate to solid electrolytes comprising nanowhiskers. More particularly, embodiments of the disclosure relate to solid electrolytes comprising PEO6LiX crystalline complex and nanowhiskers to stabilize the PEO6LiX crystalline complex.... The Penn State Research Foundation

Generating gabaergic neurons in brains

This document provides methods and materials for generating GABAergic neurons in brains. For example, methods and materials for using nucleic acid encoding a NeuroD1 polypeptide and nucleic acid encoding a Dlx2 polypeptide to trigger glial cells (e.g., NG2 glial cells or astrocytes) within the brain (e.g., striatum) into forming GABAergic... The Penn State Research Foundation

Separation of low-abundance cells from fluid using surface acoustic waves

An apparatus for sorting cells from a mixed population of cells using surface acoustic waves is described. Methods for separating cancer cells from a mixed population of cells are provided. Methods for separating cells or particles having different size, density and/or compressibility properties are also provided.... The Penn State Research Foundation

Method and therapeutic use of pign and other genes or gene products that pign interacts with for prognosis and treatment of hematological neoplasias

The invention provides a method for determining the level of risk for development or progression of a hematologic neoplasia in a subject by analyzing the level of a phosphatidylinositol glycan anchor biosynthesis protein, and providing an appropriate treatment or preventive measure, on the basis of this risk.... The Penn State Research Foundation

Small molecule trail gene induction by normal and tumor cells as an anticancer therapy and tumor cells as an anticancer therapy

Methods and compositions relating to TIC10 are described according to aspects of the present invention. The compositions and methods have utility in treating disease, particularly cancer in a subject in need thereof, including a human subject as well as subjects of other species. The compositions have utility in treating brain... The Penn State Research Foundation

Compositions and methods related to proteins capable of reversible transition to a melt

Provided are compositions and methods for making a variety of products. The methods involve mixing sucker ring teeth (SRT) protein and a plasticizer or a solvent to obtain a mixture of the SRT protein and the plasticizer. When the SRT is mixed with a plasticizer it is heated to between... The Penn State Research Foundation

Composite materials

A composite material is formed by combining an expandable polymer having a charge with another polymer having an opposite charge to produce. In particular, the composite material can be prepared by combining the polymers with a medium such as and water, and expanding the mixture using a treatment that expands... The Penn State Research Foundation

Novel triarylethylene compounds and methods using same

The present invention includes compounds useful in preventing or treating cancer in a subject in need thereof. The present invention also includes methods of preventing or treating cancer in a subject in need thereof by administering to the subject a therapeutically effective amount of a compound of the invention.... The Penn State Research Foundation

A compound for anti-cancer therapy that acts by targeting gof mutant p53 and stimulates p73 to restore the p53 pathway signaling

The invention includes compositions comprising NSC59984 or a derivative or analogue thereof and a pharmaceutically acceptable carrier. The invention further includes methods of treating or preventing cancer in a subject, comprising the step of administering to the subject the compositions contemplated within the invention.... The Penn State Research Foundation

Encapsulation and high loading efficiency of phosphorylated drug and imaging agents in nanoparticles

Method of producing nanoparticle of drug and imaging agents are provided. The phosphorylated encapsulated drugs and imaging agents could be encapsulated at therapeutic levels, were encapsulated at higher amounts. The CPSNPs were more effective in treating cancer, in reducing cancer proliferation, arresting cancer cell growth than when not in the... The Penn State Research Foundation

Antimicrobial polymers

In one aspect, compositions are described herein. In some embodiments, a composition described herein comprises the reaction product of (i) an alkoxylated or alkenoxylated citric acid, citrate, or ester of citric acid, and optionally a non-alkoxylated and non-alkenoxylated citric acid, citrate, or ester of citric acid, with (ii) a polyol.... The Penn State Research Foundation

Thermoacoustic enhancements for nuclear fuel rods and other high temperature applications

A nuclear thermoacoustic device includes a housing defining an interior chamber and a portion of nuclear fuel disposed in the interior chamber. A stack is disposed in the interior chamber and has a hot end and a cold end. The stack is spaced from the portion of nuclear fuel with... The Penn State Research Foundation

Antenna apparatus and communication system

An antenna includes a first body having a ring monopole and a second body positioned below the first body. The second body can have a plurality of notched ring resonators. A spacer can be positioned between the first and second bodies. In some embodiments, the second body can define an... The Penn State Research Foundation

Paramyxovirus virus-like particles as protein delivery vehicles

Provided are modified virus-like particles (VLPs) of paramyxoviruses, compositions containing them, methods of using the VLPs for delivery of any particular protein of interest to any of a variety of cells, kits that contain expression vectors for making, using and detecting VLPs, and methods for screening for anti-viral compounds using... The Penn State Research Foundation

06/22/17 / #20170175258

Facile route to templated growth of two-dimensional layered materials

The present invention relates to methods for fabricating a laterally-limited two-dimensional structure through template synthesis. The methods of the invention are useful in forming homogenous and heterogeneous layered materials. The invention also provides structures and devices formed by the method of the present invention and uses thereof.... The Penn State Research Foundation

06/22/17 / #20170179853

Energy harvesting device using electroactive polymer nanocomposites

An energy harvesting device includes: a first nanoporous electrode and a second nanoporous electrode, each of which is configured to which store electrical charge; a first current collector connected to the first nanoporous electrode and a second current collector connected to the second nanoporous electrode; and an enclosure that contains... The Penn State Research Foundation

06/15/17 / #20170166952

Polymer-based signal amplification for protein and cell detection

The present invention relates generally to compositions, methods and kits for detection of a molecule of interest. The present invention is based, at least in part, on the design of nucleic acid oligonucleotides such that they can be used as molecular building blocks which can be assembled (polymerized) to form... The Penn State Research Foundation

06/08/17 / #20170158768

Compositions and methods for targeting of the surfactant protein a receptor

Provided are compositions and methods for use in prophylaxis, therapy and diagnosis of conditions which involve surfactant protein receptors (SPR) including the SPR for surfactant proteins A (SPA). Specific binding partners, including mono-clonal antibodies, for the SP-R210L and SP-R210S isoforms, and methods of using such binding partners are included. Fragments... The Penn State Research Foundation

06/08/17 / #20170159013

Chemical reprogramming of human glial cells into neurons with small molecule cocktail

Provided are compositions, articles and methods that relate to promoting neurogenesis or neuroregeneration in mammalian nervous system. Embodiments relate to use of groups of compounds that contain Crizotinib (Cri), Flurbiprofen, Lithium Chloride (Li), Vitamin C (VC), Ceritinib (Cer) or Pirfenidone (PFD). In certain implementations glial cells are converted into functional... The Penn State Research Foundation

06/08/17 / #20170159121

Genomic regions with epigenetic variation that contribute to phenotypic differences in livestock

The invention provides compositions and methods for selecting milk-producing livestock with a preferred phenotype. In one embodiment, the method includes detecting methylation status of one or more genes and gene regulatory regions in a sample to identify the preferred phenotype.... The Penn State Research Foundation

06/08/17 / #20170162325

High temperature dielectric materials, manufacture thereof and articles comprising the same

Disclosed herein is a dielectric composite comprising an organic polymer that has a glass transition temperature greater than or equal to about 250° C.; and a dielectric filler present in an amount effective to impart to the dielectric composite a dielectric constant that varies by less than 5% over a... The Penn State Research Foundation

06/01/17 / #20170152283

Inhibitors of the farnesoid x receptor and uses in medicine

Disclosed are inhibitors of the farnesoid X receptor, for example of formula (I), wherein R1, R2, R4, X, Y, Z, m, and n are as defined herein, which are useful in treating or preventing obesity, type 2 diabetes/insulin resistance and non-alcoholic fatty liver disease in a mammal in need thereof.... The Penn State Research Foundation

05/25/17 / #20170145521

Compositions and methods for identifying agents to reduce hepatitis b virus covalently closed circular dna

Provided are compositions and methods for identifying test agents as candidate for use in reducing hepatitis B virus (HBV). The methods involve a) introducing at least one test agent into mammalian cells, the cells having one or more plasmids that encode an HBV genome, wherein the genome includes a segment... The Penn State Research Foundation

05/11/17 / #20170131319

Automated sampling system

The automated sampling system has a water tight case that encloses a testing instrument. In the preferred embodiment, the testing instrument is a field-portable ion chromatography instrument designed to test water samples. In operation, a controller directs a syringe pump to draw fluid from outside the system through a specialized... The Penn State Research Foundation

05/04/17 / #20170121363

Compounds, compositions and methods for coloring edible materials

The present invention provides compounds isolated from avocado seeds for use as a natural colorant in edible materials. The compounds of the invention are useful for coloring edible materials red, orange or yellow. The invention also provides compositions and methods for coloring edible materials to a desired color such as... The Penn State Research Foundation

05/04/17 / #20170121624

Self-healable coatings and methods of making the same

A robust and self-healing coating has been developed by incorporating a thermally self-healing chemical coating on smooth and/or roughened solid. When the chemically coated solid is combined with a lubricating fluid, the material system is capable to repel a broad range of liquids and solids. The thermally self-healing chemical coating... The Penn State Research Foundation

04/27/17 / #20170112136

Biofilms, components and methods of use to reduce biofouling and contamination

Biofilms are provided which are capable of regulating their own thickness, reducing contamination and preventing biofouling. Constructs are introduced into bacteria that comprise nucleic acid molecules encoding an autoinducer synthase polypeptide, a transcriptional regulator and a biofilm dispersal protein. Nucleic acid molecules may also be introduced which encode a nitric... The Penn State Research Foundation

04/27/17 / #20170112988

Smart tip lvad inlet cannula

Embodiments of the invention provide a left ventricular assist device (LVAD) cannula that includes multiple independent sensors may help decrease the incidence of ventricular collapse and provide automatic speed control. A cannula may include two or more independent sensors. One sensor may measure ventricular pressure, while another may measure ventricular... The Penn State Research Foundation

04/27/17 / #20170116369

Method for designing overall stoichiometric conversions and intervening metabolic reactions

The present invention describes a two-step computational procedure that both identifies the optimum overall stoichiometry of conversion, along with alternate co-reactant (or co-product) combinations, of a feedstock substrate to a biochemical product, and selects for (non-)native reactions accessed from a universal database to identify at least one stoichiometry-balanced minimal metabolic... The Penn State Research Foundation

04/20/17 / #20170109603

Automatically computing emotions aroused from images through shape modeling

Shape features in natural images influence emotions aroused in human beings. An in-depth statistical analysis helps to understand the relationship between shapes and emotions. Through experimental results on the International Affective Picture System (IAPS) dataset, evidence is presented as to the significance of roundness-angularity and simplicity-complexity on predicting emotional content... The Penn State Research Foundation

04/06/17 / #20170096717

Antibacterial and plasmid elimination agents

Inhibitors of the tmRNA pathway have antibacterial activity with broad species specificity, including B. anthracis and other pathogens of military and civilian interest. Identified cyclic or linear peptides are further selected by in vivo selection methods, kill bacterial pathogens when added exogenously, and/or eliminate plasmids carrying antibiotic resistance or virulence... The Penn State Research Foundation

03/30/17 / #20170088471

Cold sintering ceramics and composites

Cold sintering of materials includes using a process of combining at least one inorganic compound, e.g., ceramic, in particle form with a solvent that can partially solubilize the inorganic compound to form a mixture; and applying pressure and a low temperature to the mixture to evaporate the solvent and densify... The Penn State Research Foundation

03/23/17 / #20170079936

Compositions and methods relating to proliferative diseases

Anti-cancer compositions and methods are described herein. In particular, compositions including one or more of leelamine, a leelamine derivative, abietylamine, an abietylamine derivative, and an abietic acid derivative are described. Methods for treatment of pathological conditions particularly cancer, in a subject using one or more of leelamine, a leelamine derivative,... The Penn State Research Foundation

03/23/17 / #20170080125

Methods of promoting bone growth and healing

In one aspect, methods of promoting bone growth are described herein. In some embodiments, a method described herein comprises disposing a graft or scaffold in a bone growth site. The graft or scaffold comprises (a) a polymer network formed from the reaction product of (i) citric acid, a citrate or... The Penn State Research Foundation

03/23/17 / #20170080404

Polyolefin interpenetrated network material for hydrocarbon recovery

Interpenetrated polyolefin network for use in recovering or containing hydrocarbons such as hydrocarbons contained in oil, are disclosed. Advantageously, the interpenetrated polyolefin networks absorb the hydrocarbon, including viscous hydrocarbons and crude oils, to form a gel that can be collected and processed by heat to release the collected hydrocarbons.... The Penn State Research Foundation

03/23/17 / #20170083608

Accelerated discrete distribution clustering under wasserstein distance

Computationally efficient accelerated D2-clustering algorithms are disclosed for clustering discrete distributions under the Wasserstein distance with improved scalability. Three first-order methods include subgradient descent method with re-parametrization, alternating direction method of multipliers (ADMM), and a modified version of Bregman ADMM. The effects of the hyper-parameters on robustness, convergence, and speed... The Penn State Research Foundation

03/09/17 / #20170065728

Self-powered enzyme micropumps

Drug delivery devices, sensors, and micropumps provided herein can utilize a reaction of an analyte triggered by an enzyme to drive fluid flow. In some cases, a drug delivery device can include a reservoir including a drug (e.g., insulin) and have an enzyme (e.g., glucose oxidase) positioned adjacent to said... The Penn State Research Foundation

03/09/17 / #20170067912

Compositions and methods for diagnosing barrett's esophagus stages

Provided is an immunohistochemistry panel that facilitates the discrimination between the early and late stages of Barret's esophagus in a method that involves testing a biological sample for expression of CDX2, p120ctn, c-Myc and Jagged1 proteins, comparing the amount of the CDX2, p120ctn, c-Myc and Jagged1 proteins to reference values,... The Penn State Research Foundation

03/09/17 / #20170068795

Compositions and methods for assessing risk of autism spectrum disorder during early childhood

The invention includes an early detection system for ASD that combines the assessment of various factors and comorbid conditions to accurately generate a prediction model for assessing the degree of ASD.... The Penn State Research Foundation

03/09/17 / #20170069970

Antenna apparatus and communication system

An antenna apparatus can include a transmission medium that is positioned within layers of an antenna apparatus that are positioned adjacent to a first upper layer that is configured to include a signal receiving and transmission element (e.g. an antenna, patch antenna, etc.). The transmission medium can include or otherwise... The Penn State Research Foundation

03/02/17 / #20170059454

3d laser ablation tomography

A laser ablation tomography system includes a specimen stage for supporting a specimen. A specimen axis is defined such that a specimen disposed generally on the axis may be imaged. A laser system is operable to produce a laser sheet in a plane intersecting the specimen axis and generally perpendicular... The Penn State Research Foundation

02/16/17 / #20170045690

Optical scramblers

The disclosure features optical scramblers that can be used with spectrographs and other optical measurement systems, including Doppler-based radial velocity measurement systems and other precision spectroscopy. In one aspect, an optical scrambler includes a first fiber configured to receive measured light from an optical collection system, a second fiber configured... The Penn State Research Foundation

02/09/17 / #20170038285

Sizable tunable enrichment platform for capturing nano particles in a fluid

The invention provides enrichment platform devices for size-based capture of particles in solution. The enrichment platform device is useful for label-free capture of any particle. The invention relates to enrichment platform devices using nanowires and vertically aligned carbon nanotubes. The invention provides methods for making the enrichment platform devices. The... The Penn State Research Foundation

02/02/17 / #20170031091

Method and producing crystalline cladding and crystalline core optical fibers

We provide methods and apparatus for preparing crystalline-clad and crystalline core optical fibers with minimal or no breakage by minimizing the influence of thermal stress during a liquid phase epitaxy (LPE) process as well as the fiber with precisely controlled number of modes propagated in the crystalline cladding and crystalline... The Penn State Research Foundation

Patent Packs
01/26/17 / #20170020768

Neonatal chest splint for applying negative distending pressure

The present invention relates to devices and methods for assisting breathing in a subject. In one embodiment, the device of the present invention is a splint that can be used to apply negative distending pressure, i.e., outward pull, to one or both of the chest walls and/or the abdomen of... The Penn State Research Foundation

01/26/17 / #20170022587

Carbon-based nanotube/metal composite and methods of making the same

A nanocomposite comprising metal and carbon-based nanotube (CNT), wherein the carbon-based nanotube comprises a doping element selected from the group consisting of boron (B), iron (Fe), zinc (Zn), nickel (Ni), cadmium (Cd), tin (Sn), antimony (Sb), Nitrogen (N) and the combination thereof, and methods of making the nanocomposite.... The Penn State Research Foundation

01/26/17 / #20170023384

Intrusion detection system for an undersea environment

An intrusion detection system includes a suspended optical fiber having a neutral buoyancy and an optical time-domain reflectometer connected to the suspended optical fiber at an origin location. The suspended optical fiber is connected to a mooring at a first end of the suspended optical fiber and further includes at... The Penn State Research Foundation

01/19/17 / #20170016008

Design of mrna sequences to control co-translational folding of proteins

This invention relates to optimized heterologous production of properly folded and functional proteins. The present invention provides systems and methods involving determination of the optimal mRNA sequence, based on the underlying rates at which codons are translated and folding kinetic of nascent-protein, that maximizes co-translational protein folding of domains in... The Penn State Research Foundation

01/12/17 / #20170012351

Antenna apparatus and communication system

An antenna includes a first body having an array of resonators; a spacer adjacent to the first body, and a second body adjacent to the spacer such that the spacer is between the first and second bodies. The first body can be configured as an artificial metasurface ground plane and... The Penn State Research Foundation

01/05/17 / #20170000790

Small molecule trail gene induction by normal and tumor cells as an anticancer therapy

Methods and compositions relating to TIC10 are described according to aspects of the present invention. The compositions and methods have utility in treating disease, particularly cancer in a subject in need thereof, including a human subject as well as subjects of other species. The compositions have utility in treating brain... The Penn State Research Foundation

01/05/17 / #20170003471

Composite cable assembly with neutral buoyancy

An Above Bottom Fiber (ABF) cable includes an elongated fiber cable having microspheres adhered to the ABF by an adhesive lightly coated to the outer surface of the ABF. The elongated fiber is negatively buoyant while the microspheres and adhesives are positively buoyant, resulting in the ABF being controllably buoyant... The Penn State Research Foundation








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