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The Regents Of The University Of California
The Regents Of The University Of California A California Corporation
The Regents Of The University Of California Office Of Technology Transfer
The Regents Of The University Of California The Office Of The President
The Regents Of The University Of California Santa Cruz
The Regents Of The University Of California San Diego
The Regents Of The University Of California Corporation A California Corporation
The Regents Of The University Of California Office Of Technology
The Regents Of The University Of California And The Burnham Institute
The Regents Of The University Of California Angiodynamics Inc
The Regents Of The University Of California A University
The Regents Of The University Of California 02307w
The Regents Of The University Of California A U s Entity
The Regents Of The University Of California 1111 Franklin Street 12th Floor
The Regents Of The University Of California A Cali Fornia Corporation
The Regents Of The University Of California Office Of Technology Transfer University Of California
The Regents Of The University Of California_20100121
The Regents Of The University Of California_20100128
The Regents Of The University Of California_20131212
The Regents Of The University Of California_20100114
The Regents Of The University Of California_20100107
The Regents Of The University Of California Irvine
The Regents Of The University Of California Of Technology Transfer
The Regents Of The University Of California Davis

The Regents Of The University Of California patents


Recent patent applications related to The Regents Of The University Of California. The Regents Of The University Of California is listed as an Agent/Assignee. Note: The Regents Of The University Of California may have other listings under different names/spellings. We're not affiliated with The Regents Of The University Of California, we're just tracking patents.

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Unit aerosol doses for anticoagulation

Disclosed herein are methods for prophylactic treatment of acute coronary syndrome (ACS) comprising administering, by inhalation, an effective amount of a pharmaceutical composition comprising at least one anticoagulant or antiplatelet agent to a subject in need thereof, wherein the anticoagulant or antiplatelet agent first enters the heart via the left... The Regents Of The University Of California

Selective high-affinity polydentate ligands and methods of making such

This invention provides novel polydentate selective high affinity ligands (SHALs) that can be used in a variety of applications in a manner analogous to the use of antibodies. SHALs typically comprise a multiplicity of ligands that each bind different region son the target molecule. The ligands are joined directly or... The Regents Of The University Of California

Selective high-affinity polydentate ligands and methods of making such

This invention provides novel polydentate selective high affinity ligands (SHALs) that can be used in a variety of applications in a manner analogous to the use of antibodies. SHALs typically comprise a multiplicity of ligands that each bind different region son the target molecule. The ligands are joined directly or... The Regents Of The University Of California

Spinal subpial gene delivery system

Delivery devices, systems, and methods related thereto may be used in humans for spinal delivery of cells, drugs or vectors. Thus, the system enables subpial delivery, which leads to a near complete spinal parenchymal AAV9-mediated gene expression or ASO distribution in both white and grey matter.... The Regents Of The University Of California

Synthetic promoters for high throughput screening and gene modulation

The present invention provides nucleic acid constructs, expression vectors, transgenic cell and methods of making and using the same, wherein the nucleic acid construct includes a synthetic promoter designed from the endogenous promoter of BIRC5 and LAMC2. In illustrative working embodiments of the invention, an exogenous nucleic acid fragment encoding... The Regents Of The University Of California

Thin film cell encapsulation devices

Thin film devices, e.g., multilayer thin film devices, that encapsulate cells for transplantation into a subject are provided. Also provided are methods of using and methods of preparing the subject devices. The thin film devices include a first porous polymer layer and a second porous polymer layer that define a... The Regents Of The University Of California

Systemic delivery and regulated expression of paracrine genes for cardiovascular diseases and other conditions

In alternative embodiments, the invention provides methods for treating, ameliorating or protecting (preventing) an individual or a patient against a disease, an infection or a condition responsive to an increased paracrine polypeptide level in vivo comprising: providing a paracrine polypeptide-encoding nucleic acid or gene operatively linked to a transcriptional regulatory... The Regents Of The University Of California

Method for detecting nonsense-mediated rna decay

Certain embodiments of the invention provide a method of detecting and/or quantitating nonsense mediated RNA decay (NMD) activity in a cell, comprising 1) detecting an altered level of RNA expression of a NMD-sensitive isoform in a cell, as compared to a control cell; and 2) detecting an unaltered level of... The Regents Of The University Of California

Leukemia methylation markers and uses thereof

Disclosed herein are methods and kits for identifying a subject as having leukemia. Also provided herein are methods and kits for determining a leukemia subtype in subject. Further provided herein are methods and kits for determining the prognosis of a subject having leukemia and for determining the progression of leukemia... The Regents Of The University Of California

Method for thermally drawing nanocomposite-enabled multifunctional fibers

A method of thermally drawing fibers containing continuous crystalline metal nanowires therein includes forming a preform comprising an inner core and an outer cladding, wherein at least one of the core and cladding has nanoelements dispersed therein. The preform is drawn through a heated zone to form a reduced size... The Regents Of The University Of California

Methods of selecting and isolating cancer stem cells

Provided herein are methods for selecting/identifying and/or isolating cancer stem cells from a biological sample or a cell culture sample using a fluorescent glucose analog. Also provided herein are methods for selecting/identifying and/or isolating leukemia stem cells and subpopulations thereof. The present invention is based, in part, on the discovery... The Regents Of The University Of California

Pathway recognition algorithm using data integration on genomic models (paradigm)

The present invention relates to methods for evaluating the probability that a patient's diagnosis may be treated with a particular clinical regimen or therapy.... The Regents Of The University Of California

Bambam: parallel comparative analysis of high-throughput sequencing data

The present invention relates to methods for evaluating and/or predicting the outcome of a clinical condition, such as cancer, metastasis, AIDS, autism, Alzheimer's, and/or Parkinson's disorder. The methods can also be used to monitor and track changes in a patient's DNA and/or RNA during and following a clinical treatment regime.... The Regents Of The University Of California

Systems and methods for enhancing isolation of high-temperature reactor containments

A high-temperature containment-isolation system for transferring heat from a nuclear reactor containment to a high-pressure heat exchanger is presented. The system uses a high-temperature, low-volatility liquid coolant such as a molten salt or a liquid metal, where the coolant flow path provides liquid free surfaces a short distance from the... The Regents Of The University Of California

Technique for the growth and fabrication of semipolar (ga,al,in,b)n thin films, heterostructures, and devices

A method for growth and fabrication of semipolar (Ga,Al,In,B)N thin films, heterostructures, and devices, comprising identifying desired material properties for a particular device application, selecting a semipolar growth orientation based on the desired material properties, selecting a suitable substrate for growth of the selected semipolar growth orientation, growing a planar... The Regents Of The University Of California

Peach variety named 'vilmos'

... The Regents Of The University Of California

Telemedical wearable sensing system for management of chronic venous disorders

A telemedical interface pressure monitoring system is provided for intermittent or continuous monitoring of the pressure that occurs at the interface between the body and a support surface such as with a compression device, cast or resting surface. The system simultaneously measures interface pressure at multiple compression positions as well... The Regents Of The University Of California

Methods for immunomodulation of cancer and infectious disease therapy

The present invention provides methods for modulating the immune response of a subject to a therapeutic agent, the method comprising administering an effective amount of a triphenylethylene (TRIP) compound with an effective amount of the therapeutic agent. In particular embodiments, the TRIP compound enhances the immune response of the subject... The Regents Of The University Of California

Methods for inhibiting alpha-v beta-3 expression on cancer stem cells and inhibiting progression to a cancer stem cell phenotype

In alternative embodiments, provided are compositions and methods for treating, enhancing the drug sensitivity of, and preventing the formation of cancer stems cells, including preventing or slowing the development or generation of a beta-3 (β3)-expressing, or integrin β3 (ITG-B3)-expressing cancer or tumor cells. In alternative embodiments, provided are methods using... The Regents Of The University Of California

Compositions and methods for promoting growth of beneficial microbes to treat or prevent disease or prolong life

Inoculation of ATM-deficient mice with probiotic microorganisms, such as L. johnsonii, changed immune parameters, decreased a marker of DNA damage and increased the lifespan of the mice. Compositions and methods described herein are useful for the treatment and prevention of Ataxia telangiectasia and other cancer-prone disease, such as p53 deficiency-associated... The Regents Of The University Of California

D-amino acid derivative-modified peptidoglycan and methods of use thereof

The present disclosure provides modified bacteria and modified peptidoglycan comprising modified D-amino acids; compositions comprising the modified bacteria or peptidoglycan; and methods of using the modified bacteria or peptidoglycan. The modified D-amino acids include a bioorthogonal functional group such as an azide, an alkyne or a norbornene group. Also provided... The Regents Of The University Of California

Modified cytotoxins and their therapeutic use

The present disclosure generally provides compounds useful for treating cancer. In some aspects, the disclosure provides small-molecule cytotoxins that are chemically modified to include one or more moieties that include hydrophobic portions. In some embodiments, the disclosure provides small-molecule cytotoxins that are chemically modified with fatty acid-containing moieties. In some... The Regents Of The University Of California

Portable lung assist device

The present invention relates to a portable lung assist device. In one embodiment, the portable lung assist device comprises an integrated oxygenator, blood pump, and cannula. In one embodiment, the portable lung assist device of the present invention does not require an oxygen tank, but instead can provide oxygen to... The Regents Of The University Of California

Endovascular catheter air block

This invention is an air block for industrial, medical, and non-medical uses. For example, the air block is connected to the proximal end of a vascular access catheter. The air block is either removably connected to the proximal end of the catheter or it is integral to the proximal end... The Regents Of The University Of California

Devices, the treatment of medical disorders

The present disclosure relates to methods, devices and systems used for the treatment of medical disorders via stimulation of the superficial elements of the trigeminal nerve. More specifically, cutaneous methods of stimulation of the superficial branches of the trigeminal nerve located extracranially in the face, namely the supraorbital, supratrochlear, infraorbital,... The Regents Of The University Of California

Nanopipette manipulating cells

Disclosed herein are methods and systems for controlled ejection of desired material onto surfaces including in single cells using nanopipettes, as well as ejection onto and into cells. Some embodiments are directed to a method and system comprising nanopipettes combined with an xyz controller for depositing a user defined pattern... The Regents Of The University Of California

Oxathiazole thiazolium hsp 70 inhibitors

Provided herein are compounds of formula (I) which are, inter alia, useful allosteric inhibitors of Hsp70. The compounds and methods provided are useful for the treatment of cancer, infectious and neurodegenerative diseases.... The Regents Of The University Of California

Compositions and methods for inhibiting tumor cells by inhibiting the transcription factor atf5

The present invention relates to methods for treating and/or preventing tumors and/or promoting apoptosis in a neoplastic cell comprising contacting the neoplastic cell with an cell-penetrating dominant-negative ATF5 (“CP-d/n-ATF5”), wherein the CP-d/n-ATF5 is capable of inhibiting ATF5 function and/or activity.... The Regents Of The University Of California

Methods of diagnosing and treating autism spectrum disorders

The invention describes a method of diagnosing an individual as having an increased likelihood of having an autism spectrum disorder and in some instances, selecting a therapy. The invention is related to a system or a kit for performing such a method.... The Regents Of The University Of California

Heterodimeric cas9 and methods of use thereof

The present disclosure provides a Cas9 heterodimer, as well as nucleic acids encoding the Cas9 heterodimer, and host cells comprising the nucleic acids. The present disclosure provides a system that includes a Cas9 heterodimer of the present disclosure and at least one of: a Cas9 guide RNA, and a dimerizing... The Regents Of The University Of California

Methods for enhancing bacterial cell display of proteins and peptides

Methods of making and using bacterial display polypeptide libraries using circularly permuted OmpX (CPX) variants are disclosed. The invention further relates to methods for enhancing the display of proteins and peptides at the surface of bacteria by optimizing linkers and incorporating mutations at positions 165 and 166 of CPX.... The Regents Of The University Of California

Engineering pathogen resistance in plants

Provided herein are compounds and methods for increasing disease resistance and/or root length in plants.... The Regents Of The University Of California

Methods and compositions for labeling a single-stranded target nucleic acid

The present disclosure provides compositions and methods for labeling a single stranded target nucleic acid. Subject compositions include a Cas9 protein, a Cas9 guide RNA, and a quenched PAMmer. A subject quenched PAMmer is a single stranded oligonucleotide having (i) a protospacer adjacent motif (PAM) sequence; (ii) a detectable label;... The Regents Of The University Of California

Multigene prognostic assay for lung cancer

The present invention provides methods for providing a prognosis for lung adenocarcinoma, using a panel of eight molecular markers that are differentially expressed in lung adenocarcinoma.... The Regents Of The University Of California

Thin film deposition system capable of physical vapor deposition and chemical vapor deposition simultaneously

A multi-deposition chamber apparatus is provided that includes a first deposition chamber that includes a substrate holder, a retractable sputter gun, a gate valve, an output port, a retractable chamber separator, a gas input port, a gas output port, and an electron cyclotron resonance plasma source, where the retractable chamber... The Regents Of The University Of California

01/04/18 / #20180003560

Methods and multi-probe photonic time-stretch spectral measurements

Methods and apparatus for multi-probe photonic time-stretch spectral measurements are described. Methods allow for capturing real-time and single-shot non-overlapping spectral bands from multiple probes simultaneously, using Time-Stretch Dispersive Fourier Transform (TS-DFT) systems combined with Wavelength Division Multiplexing (WDM) device.... The Regents Of The University Of California

01/04/18 / #20180003686

Method and device for quantification of plant chlorophyll content

A system for measuring chlorophyll concentration in a leaf sample includes a leaf-holding illuminator device with a main body containing a power source, a plurality of switchable light sources emitting light at different spectra (e.g., red and white light from a broadband light source), and a cap detachably secured to... The Regents Of The University Of California

01/04/18 / #20180003717

N-acetyl glucosamine as a biomarker of ms disease course

The invention provides the art with a powerful diagnostic method of distinguishing relapse-remitting MS subjects from progressive MS subjects, based on the measurement of serum concentrations of N-acetylglucosamine (GlcNAc,), for the first time enabling rapid diagnosis of the progressive form of MS. GlcNAc serum concentration can also be used to... The Regents Of The University Of California

01/04/18 / #20180005413

Fitting procedural yarn models for realistic cloth rendering

An apparatus in one embodiment comprises a multi-stage processing pipeline configured to generate a procedural yarn model by fitting procedural yarn model parameters to input data comprising computed tomography measurements of one or more actual yarn samples. The apparatus further comprises an image rendering system configured to execute one or... The Regents Of The University Of California

01/04/18 / #20180005770

Mesoporous nanocrystalline film architecture for capacitive storage devices

A mesoporous, nanocrystalline, metal oxide construct particularly suited for capacitive energy storage that has an architecture with short diffusion path lengths and large surface areas and a method for production are provided. Energy density is substantially increased without compromising the capacitive charge storage kinetics and electrode demonstrates long term cycling... The Regents Of The University Of California

01/04/18 / #20180006730

Receiver with mutually coherent optical frequency combs

A receiver architecture for physically-assisted computing of transforms, such as discrete Fourier transforms (DFT) and discrete Hilbert transforms (DHT), employs mutually-coherent optical frequency combs for detection of the coherent beating between an optical signal and a reference optical tone generated by a local oscillator (LO). A signal replication mixer generates... The Regents Of The University Of California

12/28/17 / #20170367325

Nanoceria augmentation of plant photosynthesis under abiotic stress

A nanobionic approach for augmenting plant photoprotection and photosynthetic light energy conversion and carbon assimilation under abiotic (e.g., light) stress was used. Cerium oxide nanoparticles (nanoceria) improve Arabidopsis maximum quantum yield of photosystem II (10%) and carbon assimilation (19%) by protecting leaf mesophyll chloroplasts from damaging reactive oxygen species (ROS).... The Regents Of The University Of California

12/28/17 / #20170367592

Assessing endothelial function and providing calibrated ufmd data using a blood pressure cuff

Methods and apparatus are provided for assessing endothelial function in a mammal. In certain embodiments the methods involve using a cuff to apply pressure to an artery in a subject to determine a plurality of baseline values for a parameter related to endothelial function as a function of applied pressure... The Regents Of The University Of California

12/28/17 / #20170367648

Methods for determining total body skeletal muscle mass

The present invention is based on the finding that enrichment of D3-creatinine in a urine sample following; oral administration of a single defined dose of D3-creatine can be used to calculate total-body creatine pool size and total body skeletal muscle mass in a subject. The invention further encompasses methods for... The Regents Of The University Of California

12/28/17 / #20170367852

Semi-active robotic joint

A robotic joint comprises a first link, a middle link, a torque generator, a second link, and a locking mechanism. Different ends of the middle link are rotatably coupled to the first link and the second link. The torque generator is coupled to the first link and the middle link... The Regents Of The University Of California

12/28/17 / #20170368098

Bispecific or-gate chimeric antigen receptor responsive to cd19 and cd20

A CD19-OR-CD20 chimeric antigen receptor (CAR) protein construct is provided. Also provided are nucleic acids encoding the CD19-OR-CD20 CAR; and methods of use, e.g. in the treatment of B cell malignancies. The CD19-OR-CD20 CAR of the invention is a bispecific CAR that can trigger T-cell activation upon detection of either... The Regents Of The University Of California

12/28/17 / #20170368111

Reduction of milk glycans and their degradation products in the neonate gut

Methods of reducing milk glycans, and thus enteric pathogens that use such glycans as carbon sources, in the gut of nursing mammals.... The Regents Of The University Of California

12/28/17 / #20170368173

Cancer treatment combinations

There are provided, inter alia, compositions and methods for treatment of cancer. The methods include administering to a subject in need a therapeutically effective amount of a Bruton's tyrosine kinase (BTK) antagonist and a ROR-1 antagonist. Further provided are pharmaceutical compositions including a BTK antagonist, ROR-1 antagonist and a pharmaceutically... The Regents Of The University Of California

12/28/17 / #20170368224

Controllable self-annealing microgel particles for biomedical applications

A microporous gel system for certain applications, including biomedical applications, includes an aqueous solution containing plurality of microgel particles including a biodegradable crosslinker. In some aspects, the microgel particles act as gel building blocks that anneal to one another to form a covalently-stabilized scaffold of microgel particles having interstitial spaces... The Regents Of The University Of California

12/28/17 / #20170368574

Piezoelectric transducers and methods of making and using the same

Piezoelectric transducers are provided. The piezoelectric transducer includes a first piezoelectric layer, a second piezoelectric layer disposed on at least a portion of the first piezoelectric layer, and a middle electrode layer disposed between the first and second piezoelectric layers, where the middle electrode layer includes an inner region and... The Regents Of The University Of California

12/28/17 / #20170369323

Production of carbon-based oxide and reduced carbon-based oxide on a large scale

Provided herein are carbon-based oxide (CBO) materials and reduced carbon-based oxide (rCBO) materials, fabrication processes, and devices with improved performance and a high throughput. In some embodiments, the present disclosure provides materials and methods for synthesizing CBO and rCBO materials. Such methods avoid the shortcomings of current synthesizing methods to... The Regents Of The University Of California

12/28/17 / #20170369468

Anthropod repellent chemicals

Compositions and methods for repelling arthropods. The compositions include a carrier and an arthropod repelling compound, which can be a compound discovered by a novel and complex cheminformatic process to demonstrate repellency behavior across a broad spectrum of arthropods. The compound can be a thiane compound, a pyrrolidone compound, a... The Regents Of The University Of California

12/28/17 / #20170369950

Biomarkers of response to inhibition of poly-adp ribose polymerase (parp) in cancer

Provided herein are methods of identifying a subject having a poly-ADP ribose polymerase (PARP) inhibitor-sensitive tumor by detecting a genomic gain in chromosome 1q21 and/or chromosome 20q13.3 in a tumor sample from the subject. Also provided are methods of identifying a subject having a PARP inhibitor-sensitive tumor by detecting gene... The Regents Of The University Of California

12/28/17 / #20170370843

Facilitating real-time visualization of tissue features derived from optical signals

The disclosed embodiments relate to a system that displays an image of the characteristics of the biological tissue. During operation, the system enables a user to illuminate a measurement location in an area of interest on the biological tissue by manipulating a point measurement probe, wherein the point measurement probe... The Regents Of The University Of California

12/28/17 / #20170370916

High-sensitive fluorescent energy transfer assay using fluorescent amino acids and fluorescent proteins

The disclosure provides method and composition utilizing fluorescent amino acids and fluorescent proteins comprising a moiety capable of undergoing FRET. The methods and compositions of the disclosure are useful in analyzing protein structure and function, and screening molecular inhibitors.... The Regents Of The University Of California

12/28/17 / #20170372867

Left-right canted-cosine-theta magnets

Disclosed herein are superconducting gantry magnets that include multiple quadrupole winding sections placed in sequence on a curve such that the effective current direction is reversed between sections. This produces alternating quadrupole field regions along the length of the bend whose individual integral strengths can be tuned by the location... The Regents Of The University Of California

12/28/17 / #20170373342

Battery with molybdenum sulfide electrode and methods

A battery having a metal sulfide electrode, and an aluminum containing electrolyte and methods are shown. In one example, the electrolyte includes one or more organic salts. In one example, the metal sulfide includes molybdenum sulfide. In one example, the metal sulfide includes titanium sulfide.... The Regents Of The University Of California

12/21/17 / #20170360048

Methods and compositions for nucleic acid integration

The disclosure provides methods and compositions for the integration (insertion) of a donor DNA molecule into a target DNA molecule. In general, the methods include contacting a target DNA molecule with a linear donor DNA molecule and a Cas 1 protein, where the target DNA molecule includes an AT-rich region... The Regents Of The University Of California

12/21/17 / #20170360557

Delivery system for percutaneous delivery and implantation of atrioventricular heart valves

Described is a delivery system for percutaneous delivery and implantation of a heart valve. The delivery system includes a handle with a sheath extending therefrom. A splay shaft extends from the handle through the sheath. At least two arms extend from the handle through the splay shaft. The at least... The Regents Of The University Of California

12/21/17 / #20170360588

Trunk supporting exoskeleton and use

A trunk supporting exoskeleton comprises: a supporting trunk; thigh links configured to move in unison with a wearer's thighs; and first and second torque generators located on both left and right halves of the wearer substantially close to the wearer's hip. The torque generators couple the supporting trunk to the... The Regents Of The University Of California

12/21/17 / #20170360717

Nanowire-coated microdevice and making and using the same

A microdevice containing a plurality of nanowires on a biocompatible surface, and methods of making and using the same are provided. Aspects of the present disclosure include forming a plurality of microdevices on a substrate where each microdevice includes a plurality of nanowires. The nanowires may be loaded with an... The Regents Of The University Of California

12/21/17 / #20170360847

Cyclic di-amp induction of type i interferon

Methods of modulating type-I interferon production in a cell are provided. Aspects of the methods include modulating cytosolic cyclic di-adenosine monophosphate (c-di-AMP) activity in the cell in a manner sufficient to modulate type-I interferon production in the cell. Additional aspects of the invention include c-di-AMP activity modulatory compositions, e.g., c-di-AMP,... The Regents Of The University Of California

12/21/17 / #20170361007

Gas exchange composite membranes and methods of use thereof

Provided herein is a gas exchange composite membrane and methods of making the same. The gas exchange composite membrane may find use in a method of exchanging gas with blood in a subject in need of blood oxygenation support, which method is also disclosed. Also provided herein are systems and... The Regents Of The University Of California

12/21/17 / #20170362173

Anti-arrhythmicity agents

Agents, compositions, and methods for regulating cardiac rhythmicity are disclosed.... The Regents Of The University Of California

12/21/17 / #20170362179

Quinolines, polyquinolines, molecular segments of fullerenes and graphene nanoribbons, and graphene nanoribbons and methods of their synthesis

Quinolines, polyquinolines, polybenzoquinolines, molecular segments of fullerenes and graphene nanoribbons, and graphene nanoribbons and processes for producing such materials are provided. The processes utilize a form of an aza-Diels-Alder (Povarov) reaction to first form quinolines and/or polyquinolines. In some such embodiments polyquinolines thus produced are used to form graphene nanoribbon... The Regents Of The University Of California

Patent Packs
12/21/17 / #20170362263

Phosphorus ligands and methods of use

In one embodiment, the application discloses ligands, such as a ligand from a dihydrobenzo[1,3] oxaphosphole scaffold, and palladium complexes comprising the ligands and methods for performing cross coupling reactions and asymmetric cross coupling reactions with high selectivity and efficiency.... The Regents Of The University Of California

12/21/17 / #20170362292

S-alkylated hepcidin peptides and methods of making and using thereof

Disclosed herein S-alkylated hepcidin peptides and methods of making and using thereof. In some embodiments, the present invention is directed to an S-alkylated hepcidin peptide having the following Structural Formula IA or IB. In some embodiments, the present invention is directed to a composition comprising at least one S-alkylated hepcidin... The Regents Of The University Of California

12/21/17 / #20170362330

Macropinocytosing human anti-cd46 antibodies and targeted cancer therapeutics

In various embodiments human anti-CD46 antibodies that are internalizing and enter tumor cells via the macropinocytosis pathway are provided, as well as antibody-drug conjugates (ADCs) developed from these antibodies for diagnostic and/or therapeutic targeting of CD46-overexpressing tumors.... The Regents Of The University Of California

12/21/17 / #20170362332

Cd47 targeted therapies for the treatment of infectious disease

Methods are provided for treating a subject with for an intracellular pathogen infection, by administering an agent that reduces the binding of CD47 on a infected cell to SIRPα on a host phagocytic cell, in an effective dose for increasing the phagocytosis of infected cells.... The Regents Of The University Of California

12/21/17 / #20170362380

Oxime cross-linked biocompatible polymer hydrogels and methods of use thereof

Methods and hydrogels for preventing or reducing cellular adhesion and protein adsorption to a tissue (e.g. cardiac tissue) are disclosed. The hydrogels generally include at least two component polymers, a first polymer including an aminooxy group and a second polymer including a reactive oxo group, that are cross-linked by oxime... The Regents Of The University Of California

12/21/17 / #20170362504

Three-dimensional structures of mesogenic ligand-functionalized nanoparticles and methods of making and using the same

Three-dimensional structures of stably associated mesogenic ligand-functionalized nanoparticles are provided. Compositions that include these structures, as well as methods of making the structures are also provided. The structures, compositions and methods find use in a variety of applications, such as light emitting devices (e.g., video displays, lights, etc.), inks, photonics... The Regents Of The University Of California

12/21/17 / #20170362563

Method and device for separation of particles and cells using gradient magnetic ratcheting

A system is provided for the quantitative magnetic separation of magnetic objects (e.g., particles or cells). The system uses magnetic ratcheting over arrays of ferromagnetic elements having gradient spacing manifested in various pitch zones that are encountered by the magnetic objects as they traverse the array. The system can be... The Regents Of The University Of California

12/21/17 / #20170362582

Cytotoxic molecules responsive to intracellular ligands for selective t cell mediated killing

Compositions and methods are provided for the cell-mediated targeted killing of diseased cells based on the presence of an intracellular antigen, rather than a surface-bound marker. The targeting cells are modified to express a cytotoxic protein that is delivered into a targeted cell, and after delivery is selectively activated by... The Regents Of The University Of California

12/21/17 / #20170362644

Methods and compositions for detecting a target rna

The present disclosure provides methods for detecting a single-stranded target RNA. The present disclosure provides methods of cleaving a precursor C2c2 guide RNA array into two or more C2c2 guide RNAs. The present disclosure provides a kit for detecting a target RNA in a sample.... The Regents Of The University Of California

12/21/17 / #20170364634

Bambam: parallel comparative analysis of high-throughput sequencing data

The present invention relates to methods for evaluating and/or predicting the outcome of a clinical condition, such as cancer, metastasis, AIDS, autism, Alzheimer's, and/or Parkinson's disorder. The methods can also be used to monitor and track changes in a patient's DNA and/or RNA during and following a clinical treatment regime.... The Regents Of The University Of California

12/14/17 / #20170356850

Liquid core photonic crystal fiber biosensors using surface enhanced raman scattering and methods for their use

The invention is drawn to a photonic crystal fiber that can be used with nanoparticles to detect and quantify components in a test sample. The invention further relates to methods of using the photonic crystal fiber for detecting chemical and biological analytes, and in use in optical communications.... The Regents Of The University Of California

12/14/17 / #20170354349

Wifi-based person-identification technique for use in smart spaces

The disclosed embodiments relate to the design of a system that identifies a person. During operation, the system receives channel state information (CSI) for a set of orthogonal frequency division modulation (OFDM) subcarriers while the person moves in a region that includes two or more nodes that use the set... The Regents Of The University Of California

12/14/17 / #20170354613

Stealth nanocapsules for protein delivery

The invention relates to methods and materials for extending a circulating half-life of a protein. The method comprises conjugating a protein with a polymerizable acryloyl group and encapsulating the protein with a layer of poly(2-methacryloxyloxyethyl phosphorycholine) (pMPC). The layer of pMPC comprises a plurality of 2-methacryloxyloxyethyl phosphorycholine monomers (MPC) polymerized... The Regents Of The University Of California

12/14/17 / #20170354745

Targeted disruption of a csf1-dap12 pathway member gene for the treatment of neuropathic pain

The invention provides compositions and methods for treating neuropathic pain. Specifically, the disclosure provides a polynucleotide comprising a trigeminal ganglion (TGG) or dorsal root ganglion (DRG) promoter operably linked to a recombinant nucleic acid encoding an endonuclease that binds to a nucleotide sequence in the human colony stimulating factor 1... The Regents Of The University Of California

12/14/17 / #20170355675

Sulfur-containing compounds targeting vesicular acetylcholine transporter

The present invention generally relates to various compounds that are useful as vesicular acetylcholine transporter (VAChT) ligands. The invention further relates to methods of using these compounds and their radiolabeled analogs for the detection of neurodegenerative diseases including Parkinson's disease (PD), and Alzheimer's disease (AD).... The Regents Of The University Of California

Patent Packs
12/14/17 / #20170355905

Novel thallium doped sodium, cesium or lithium iodide scintillators

The present invention provides for a composition comprising a crystal composition or inorganic scintillator comprising a thallium doped sodium iodide, cesium iodide, or lithium iodide scintillator useful for detecting nuclear material.... The Regents Of The University Of California

12/14/17 / #20170356850

Liquid core photonic crystal fiber biosensors using surface enhanced raman scattering and methods for their use

The invention is drawn to a photonic crystal fiber that can be used with nanoparticles to detect and quantify components in a test sample. The invention further relates to methods of using the photonic crystal fiber for detecting chemical and biological analytes, and in use in optical communications.... The Regents Of The University Of California

12/14/17 / #20170357052

Multi-mode waveguide using space-division multiplexing

A multi-mode optical waveguide device is formed from a plurality of periodically structured waveguides, where each waveguide is configured to guide a carrier signal comprising one spatial mode of a plurality of spatial modes and has at least one segment of each waveguide with a waveguide width that periodically changes... The Regents Of The University Of California

12/14/17 / #20170357083

Maskless imaging of dense samples using multi-height lensfree microscope

A method of imaging includes illuminating a sample spaced apart from an image sensor at a multiple distances. Image frames of the sample obtained at each distance are registered to one another and lost phase information from the registered higher resolution image frames is iteratively recovered. Amplitude and/or phase images... The Regents Of The University Of California

12/14/17 / #20170358419

Method of fabricating tungsten scandate nano-composite powder for cathodes

Methods for fabricating refractory metal scandate nanocomposite powders with homogeneous microstructured refractory metal grains and a uniform nanosized dispersion of scandia are provided. The powders prepared by the sol-gel methods have a spherical morphology, a narrow distribution of particle sizes and a very uniform dispersion of nanosized scandia particles joined... The Regents Of The University Of California

12/14/17 / #20170359752

Congestion reduction of lte networks

Optimal reduction of 4G LTE cellular network congestion utilizes two components of learning and optimization. First, an MLPDL learning approach is used to model cellular network congestion measured in terms of PRB utilization and predict 80% utilization as breakpoint thresholds of cellular towers as a function of average connected user... The Regents Of The University Of California

12/14/17 / #20170359754

Learning-constrained optimal enhancement of cellular networks capacity

Optimal enhancement of 3G cellular network capacity utilizes two components of learning and optimization. First, a pair of learning approaches are used to model cellular network capacity measured in terms of total number of users carried and predict breakpoints of cellular towers as a function of network traffic loading. Then,... The Regents Of The University Of California

12/07/17 / #20170347925

Microneedle arrays for biosensing and drug delivery

Methods, structures, and systems are disclosed for biosensing and drug delivery techniques. In one aspect, a device for detecting an analyte and/or releasing a biochemical into a biological fluid can include an array of hollowed needles, in which each needle includes a protruded needle structure including an exterior wall forming... The Regents Of The University Of California

12/07/17 / #20170347943

Methods and the assessment of gingival blood flow

Disclosed herein are methods and apparatus for diagnosing a disease in the gingival region of an individual, comprising: quantitatively measuring blood flow or changes in blood flow in the gingival region of the individual, potentially comparing these data to that of a healthy subject, and diagnosing the disease based one... The Regents Of The University Of California

12/07/17 / #20170348337

Multifunctional membrane-active aminoglycoside-peptide conjugates

Compositions and methods are disclosed that relate to aminoglycoside-linker-peptide (P-L-A) conjugates having unexpectedly advantageous dual-function bactericidal properties. Encompassed compounds are shown to be capable of energy independent bacterial plasma membrane disruption and to exhibit potent toxicity to bacteria including antibiotic-resistant bacteria. These and related embodiments will find uses for treating... The Regents Of The University Of California

12/07/17 / #20170348521

Extracranial implantable devices, the treatment of medical disorders

The present disclosure relates to methods, devices and systems used for the treatment of medical disorders via stimulation of the superficial elements of the trigeminal nerve. More specifically, minimally invasive systems, devices and methods of stimulation of the superficial branches of the trigeminal nerve located extracranially in the face, namely... The Regents Of The University Of California

12/07/17 / #20170348665

Lanthanide-chelator combinatorial barcoding

Disclosed herein are methods for tracking solutions, (e.g., reaction conditions in solutions). In some embodiments, the method comprises: contacting a first lanthanide-chelator complex to a first solution to generate a first barcoded solution, wherein the first lanthanide-chelator complex comprises a first lanthanide chelated by a first chelator; contacting a second... The Regents Of The University Of California

12/07/17 / #20170349651

Prevention and treatment of synucleinopathic and amyloidogenic disease

The invention provides improved agents and methods for treatment of diseases associated with synucleinopathic diseases, including Lewy bodies of alpha-synuclein in the brain of a patient. Such methods entail administering agents that induce a beneficial immunogenic response against the Lewy body. The methods are particularly useful prophylactic and therapeutic treatment... The Regents Of The University Of California

12/07/17 / #20170349909

Modulation of expression of acyltransferases to modify hydroxycinnamic acid content

The invention provides methods of engineering plants to modulate hydroxycinnamic acid content. The invention additionally provides compositions and methods comprising such plants.... The Regents Of The University Of California

12/07/17 / #20170349950

T cell balance gene expression, compositions of matters and methods of use thereof

This invention relates generally to compositions and methods for identifying the regulatory network that modulates, controls or otherwise influences T cell balance, for example, Th17 cell differentiation, maintenance and/or function, as well compositions and methods for exploiting the regulatory network that modulates, controls or otherwise influences T cell balance in... The Regents Of The University Of California

12/07/17 / #20170350803

Parallel flow cytometer using radiofrequency multiplexing

An imaging flow cytometry apparatus and method which allows registering multiple locations across a cell, and/or across multiple flow channels, in parallel using radio-frequency-tagged emission (FIRE) coupled with a parallel optical detection scheme toward increasing analysis throughput. An optical source is modulated by multiple RF frequencies to produce an optical... The Regents Of The University Of California

12/07/17 / #20170350848

Chemometric analysis of chemical agents using electrochemical detection and classification techniques

Methods, systems, and devices are disclosed for the identification of chemical agents and determination of their level of exposure using electrochemical detection and advanced signal processing. In one aspect, a method includes collecting a sample from a surface containing a chemical agent to an electrode on a sensor such that... The Regents Of The University Of California

12/07/17 / #20170350901

Mass spectrometry-cleavable cross-linker

Provided herein is synthesis of a novel acidic acid residue targeting sulfoxide-containing MS-cleavable homobifunctional cross-linker. The novel mass spectrometry-cleavable cross-linking agents can be used in mass spectrometry to facilitate structural analysis of intra-protein interactions in proteins and inter-protein interactions in protein complexes. Also disclosed herein are data based on the... The Regents Of The University Of California

12/07/17 / #20170350903

Molecular flux rates through critical pathways measured by stable isotope labeling in vivo, as biomarkers of drug action and disease activity

The methods described herein enable the evaluation of compounds on subjects to assess their therapeutic efficacy or toxic effects. The target of analysis is the underlying biochemical process or processes (i.e., metabolic process) thought to be involved in disease pathogenesis. Molecular flux rates within the one or more biochemical processes... The Regents Of The University Of California

12/07/17 / #20170353048

Near-field wireless power transfer system with immunity to distance and/or load variations

Wireless power transfer systems in accordance with embodiments of the invention are disclosed. In one embodiment, a wireless power transfer system includes a power transmitter driven by an oscillator, a power receiver including a resistive load, and a coupled resonator link configured to deliver power from a transmitter tank circuit... The Regents Of The University Of California

12/07/17 / #20170353855

Privacy-preserving stream analytics

Privacy-preserving stream analytics (personal data collection method, apparatus, and/or system) from an electronic (e.g., mobile) device providing communications, such as to a network (e.g., Internet). Data queries from a data analyst are received but not directly answered with a truthful query response. Truthful responses are privatized and anonymized based on... The Regents Of The University Of California








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