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The Regents Of The University Of Colorado A Body Corporate
The Regents Of The University Of Colorado A Body Corporated

The Regents Of The University Of Colorado A Body Corporate patents


Recent patent applications related to The Regents Of The University Of Colorado A Body Corporate. The Regents Of The University Of Colorado A Body Corporate is listed as an Agent/Assignee. Note: The Regents Of The University Of Colorado A Body Corporate may have other listings under different names/spellings. We're not affiliated with The Regents Of The University Of Colorado A Body Corporate, we're just tracking patents.

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 new patent  Modular intraocular lens designs and methods

A modular IOL system including intraocular primary and secondary components, which, when combined, form an intraocular optical correction device, wherein the secondary component is placed on the primary component within the perimeter of the capsulorhexis, thus avoiding the need to touch or otherwise manipulate the capsular bag. The secondary component... The Regents Of The University Of Colorado A Body Corporate

Compositions and methods for preventing or treating pulmonary hypertension

The present invention provides a method of treating and/or preventing pulmonary hypertension in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of a bioactive peptide preparation derived from at least one botanical source.... The Regents Of The University Of Colorado A Body Corporate

Use of viscoelastic analysis for predicting massive hemorrhage

The invention provides methods for identifying a patient as likely to have an onset of massive hemorrhage. In one embodiment, the invention provides a method for identifying a patient as likely to have an onset of massive hemorrhage, the method comprising measuring at least one of first coagulation characteristic parameter... The Regents Of The University Of Colorado A Body Corporate

Sequence specific and organism specific antimicrobials and related materials and methods

Described herein are RNA-based antisense therapeutics to target antibiotic resistant bacteria. The antisense therapeutics disclosed herein can be useful in re-sensitizing drug-resistant bacteria to antibiotics, as well as developing antibiotics that have bactericidal or bacteriostatic effects on the drug-resistant bacteria or are capable of preventing emergence of antibiotic resistance. Also... The Regents Of The University Of Colorado A Body Corporate

Intraocular device for dual incisions

A microsurgical device and methods of its use can be used for treatment of various conditions including eye diseases, such as glaucoma, using minimally invasive surgical techniques. A dual-blade device can be used for cutting the trabecular meshwork (“TM”) in the eye. The device tip provides entry into the Schlemm's... The Regents Of The University Of Colorado A Body Corporate

Compositions and methods for camkii inhibitors and uses thereof

Embodiments herein generally relate to methods, compositions and uses of CaMKII inhibitors. Other embodiments relate to methods, compositions and uses of agents that target CaMKII. Yet further embodiments relate to compositions, methods and uses of CaMKIIN-derived molecules and other CaMKII inhibitor molecules that inhibit autonomous CaMKII activity. In accordance with... The Regents Of The University Of Colorado A Body Corporate

Methods for generating barcoded combinatorial libraries

Provided herein are methods and composition for trackable genetic variant libraries. Further provided herein are methods and compositions for recursive engineering. Further provided herein are methods and compositions for multiplex engineering. Further provided herein are methods and compositions for enriching for editing and trackable engineered sequences and cells using nucleic... The Regents Of The University Of Colorado A Body Corporate

Hybrid feedforward control architecture and related techniques

A systematic procedure for the synthesis of hybrid feedforward control architectures for pulse-width modulated (PWM) switching converters is provided. In this hybrid feedforward control architecture selected converter variables are sensed and utilized in a particular way based on the converter open-loop characteristics to determine the duty-cycle needed to achieve a... The Regents Of The University Of Colorado A Body Corporate

Matching networks for wireless power transfer and related techniques

In one implementation, an analytical approach to determining an improved and/or optimal design of a matching network in a capacitive or inductive WPT system is provided. In one implementation, for example, a framework is provided to enable stage(s) of the network to simultaneously provide gain and compensation. The multistage matching... The Regents Of The University Of Colorado A Body Corporate

Multistage matching network and related techniques

Multistage matching networks and analytical frameworks for improving and/or optimizingthe networks is provided. In one example, a framework relaxes the resistive constraint on the input and load impedances of the stages of a multistage matching network and allows them to be complex. Based on this framework, the design of multistage... The Regents Of The University Of Colorado A Body Corporate

Fkbp52-specific androgen receptor inhibitor, mjc13, for use in treating breast cancer

Embodiments of the current invention include methods and compositions for treating breast cancer by administering an effective amount of MJC13 to a subject in need thereof.... The Regents Of The University Of Colorado A Body Corporate

Ligand-exchangeable nanoparticles and methods of making the same

An aspect of the present disclosure is a nanocrystal that includes a nanocrystal core and a ligand coordinated to a surface of the nanocrystal core, where the ligand includes a functionalized aromatic molecule. In some embodiments of the present disclosure, the functionalized aromatic molecule may include at least one of... The Regents Of The University Of Colorado A Body Corporate

Ultrawideband co-polarized simultaneous transmit and receive aperture (star)

In various implementations, designs of relatively simple ultra-wideband STAR front-end systems are provided. For example, such systems may include implementations utilizing a plurality of antenna arms in which a first portion of the arms is configured to transmit and a second portion of the arms is configured to receive. In... The Regents Of The University Of Colorado A Body Corporate

Peptides for modulating t-cell activity and uses therof

The present invention provides methods and materials for treating and preventing autoimmune diseases. In particular, the present invention relates to the discovery that small peptides are capable of interacting with CD40, thereby interfering with the ability of CD40 to interact with CD154, which is important in inflammation. The present invention... The Regents Of The University Of Colorado A Body Corporate

Apparatus, method, and system for filter based cell capture and labeling with configurable laydown area

Devices and methods for labeling and mounting suspended cells in a controllable area are disclosed. The devices and methods utilize polycarbonate filters. The filters are employed both to capture the cells and as a substrate for labeling. This disclosure provides a device for cell capture and staining. This device utilizes... The Regents Of The University Of Colorado A Body Corporate

Nanoparticles for photovoltaic and led devices and methods of making the same

The present disclosure relates to a composition that includes a particle and a surface species, where the particle has a characteristic length between greater than zero nm and 100 nm inclusively, and the surface species is associated with a surface of the particle such that the particle maintains a crystalline... The Regents Of The University Of Colorado A Body Corporate

Identification of novel disease states using viscoelastic analysis in the presence of an thrombolytic agent

In some embodiments, the invention provides methods for detecting an aberrant fibrinolysis condition in a patient. The method includes subjecting a blood sample from the patient to a viscoelastic analysis in the presence of a known amount of a thrombolytic agent, to obtain a coagulation characteristic value of the patient;... The Regents Of The University Of Colorado A Body Corporate

Superconducting cables and methods of making the same

A bundle of superconducting cables employs a plurality of superconducting cables, each having a former and a plurality of superconducting tape conductors wound in at least one layer around the former in a helical fashion. Each superconducting tape conductor has at least one superconducting layer. Each superconducting cable lacks an... The Regents Of The University Of Colorado A Body Corporate

Stable silicon-ionic liquid interface lithium-ion batteries

The disclosure includes a composition of matter including a film formed on substantially all nSi-cPAN particles included in an electrode, the film including fluorine, oxygen, sulfur, carbon and lithium.... The Regents Of The University Of Colorado A Body Corporate

Human papilloma virus constructs

Embodiments of the present invention provide compositions and methods for recombinantly generating tagless constructs of proteins or peptides. In certain embodiments, recombinant proteins or peptides disclosed herein concern human papilloma virus (HPV). Other embodiments concern using these constructs in compositions to elicit immune responses in a subject to one or... The Regents Of The University Of Colorado A Body Corporate

Lithium all-solid-state battery

An all-solid-state lithium battery, thermo-electromechanical activation of Li2S in sulfide based solid state electrolyte with transition metal sulfides, and electromechanical evolution of a bulk-type all-solid-state iron sulfur cathode, are disclosed. An example all-solid-state lithium battery includes a cathode having a transition metal sulfide mixed with elemental sulfur to increase electrical... The Regents Of The University Of Colorado A Body Corporate

Thermal and thermoacoustic nanodevices and methods of making and using same

In one aspect, the present invention provides nano-scale heaters, such as nano-scale thermoacoustic loudspeakers comprising suspended metal nanobridges prepared using atomic layer deposition (ALD). The loudspeakers of the invention are capable of producing audible sound when stimulated with an electrical current or other energetic stimulus. In another aspect, the present... The Regents Of The University Of Colorado A Body Corporate

Intraocular lens designs for improved stability

Intraocular lenses (IOLs) that improve lens stability by, for example, increasing anterior-posterior stiffness of the IOL, increasing anterior-posterior dimensions of the IOL and/or increasing contact area with the equator of the bag to resist movement of the IOL as the bag collapses over time. These IOLs may be non-modular (single... The Regents Of The University Of Colorado A Body Corporate

Venous access catheters and methods for portal venous system catheterization

The present invention contemplates devices and methods to administer nutritional compositions and/or therapeutic drugs directly into a portal venous system. For example, total parenteral nutrition therapy may be administered directly into the hepatic portal venous system thus circumventing known side effects of conventional parenteral administration. Alternatively, hepatic diseases and disorders... The Regents Of The University Of Colorado A Body Corporate

Linkers for protein interaction profiling and methods of making and using the same

Crosslinking compounds for effective and efficient cross-linking and identification of intermolecular and intramolecular interactions of proteins, peptides and nucleic acids.... The Regents Of The University Of Colorado A Body Corporate

Crispr enabled multiplexed genome engineering

Described herein are methods and vectors for rational, multiplexed manipulation of chromosomes within open reading frames (e.g., in protein libraries) or any segment of a chromosome in a cell or population of cells, in which various CRISPR systems are used.... The Regents Of The University Of Colorado A Body Corporate

Cmos compatible optical modulators

Ring modulators based on interdigitated junctions may be driven in full or partial standing wave mode and, active regions (providing the modulation) and light-absorptive regions (e.g. providing electrical conduction) are placed in a pattern inside a resonant cavity in order to match the maxima and minima of the optical field,... The Regents Of The University Of Colorado A Body Corporate

Hemodynamic reserve monitor and hemodialysis control

Tools and techniques for estimating a probability that a patient is bleeding or has sustained intravascular volume loss (e.g., due to hemodialysis or dehydration) and/or to estimate a patient's current hemodynamic reserve index, track the patient's hemodynamic reserve index over time, and/or predict a patient's hemodynamic reserve index in the... The Regents Of The University Of Colorado A Body Corporate

Measuring distance and contact force during robotic manipulation

A force, distance and contact measurement system comprising at least one low-cost tactile sensor embedded in elastomer and retrofitted onto existing robotic grippers is provided. The sensor is simple to manufacture and easy to integrate with existing hardware. The sensor can be arranged in strips and arrays, facilitating manipulation tasks... The Regents Of The University Of Colorado A Body Corporate

Compositions comprising anisotropic nanoparticle liquid crystal dispersions having tunable optical properties

Disclosed herein are compositions, comprising one or more types of surface modified anisotropic nanoparticles dispersed in a liquid crystal. The compositions provide tunable methods for modifying light and energy flow.... The Regents Of The University Of Colorado A Body Corporate

Rapid detection of bleeding following injury

Novel tools and techniques are provided for assessing, predicting and/or estimating a probability that a patient is bleeding, in some cases, noninvasively. In various embodiments, tools and techniques are provided for implementing rapid detection of bleeding of the patient or implementing assessment, prediction, or estimation of a probability of bleeding... The Regents Of The University Of Colorado A Body Corporate

Methods of treating autoimmunity

Methods of treating, ameliorating, or inhibiting the development of autoimmune diseases by modulating the binding of MHC class II molecules to antigenic peptides or fragments of antigenic peptides of the autoimmune disease. The binding may be modulated by the administration of D-α-methyldopa, or pharmaceutical compositions comprising therapeutically effective amounts of... The Regents Of The University Of Colorado A Body Corporate

Modular bioelectrochemical systems and methods

Bioelectrochemical systems (BES) having configurations with spiral wound structures and with frame-and-plate structures are provided. Systems may allow for production of an electrical current that is at least partially generated by anodophilic microorganisms connected directly or indirectly to an electrode. A spiral wound or frame-and-plate type bioelectrochemical system may include... The Regents Of The University Of Colorado A Body Corporate

Ocular tissue expansion ring

The present disclosure relates to a structure used in an ophthalmic surgical procedure. The device may be used in pupil expansion or stabilization of the iris. The device is made out of an elastic or semielastic material in a shape that is conducive to easy insertion and removal as well... The Regents Of The University Of Colorado A Body Corporate

Targeting breast cancer therapy based on stromal subtypes and cd146 composition

Methods for targeted breast cancer therapy in a subject based upon evaluating the stromal subtypes and CD146 composition in the adjacent tissue. ER+ breast cancers contain two CAF subtypes defined by CD146 expression. CD146neg CAFs suppress ER expression in ER+ breast cancer cells, decrease tumor cell sensitivity to estrogen, switch... The Regents Of The University Of Colorado A Body Corporate

09/21/17 / #20170269297

Method and optical waveguide-to-semiconductor coupling for integrated photonic circuits

A grating coupler couples a waveguide to a beam and is formed of patterned shapes in a first and second layer of planar material, the shapes embedded in background material, the layers separated by less than one wavelength. The shapes are organized as a plurality of adjacent unit cells arranged... The Regents Of The University Of Colorado A Body Corporate

09/14/17 / #20170260589

Point mutations in trk inhibitor-resistant cancer and methods relating to the same

Provided herein are methods of treating a subject having a cancer, methods of selecting a treatment for a subject having a cancer, methods of selecting a subject having a cancer for a treatment that does not include a Trk inhibitor, methods of determining the likelihood that a subject having a... The Regents Of The University Of Colorado A Body Corporate

09/07/17 / #20170253865

Human cystathionine beta-synthase variants and methods of production thereof

Human cystathionine β-synthase variants are disclosed, as well as a method to produce recombinant human cystathionine β-synthase and variants thereof. More particularly, the role of both the N-terminal and C-terminal regions of human CBS has been studied, and a variety of truncation mutants and modified CBS homologues are described. In... The Regents Of The University Of Colorado A Body Corporate

08/31/17 / #20170247767

Biomarkers for head and neck cancer and methods of their use

Disclosed is a diagnostic panel of methylated genomic loci encoding microRNA (mgmiR) markers that demonstrated 90% sensitivity and 100% specificity in the detection of head and neck squamous cell carcinoma (HNSCC). These results represent the first use of quantitative MS-PCR for the detection of mgmiRs. In addition this panel demonstrates... The Regents Of The University Of Colorado A Body Corporate

08/31/17 / #20170248381

Radiative cooling structures and systems

Polymer-based selective radiative cooling structures are provided which include a selectively emissive layer of a polymer or a polymer matrix composite material. Exemplary selective radiative cooling structures are in the form of a sheet, film or coating. Also provided are methods for removing heat from a body by selective thermal... The Regents Of The University Of Colorado A Body Corporate

08/24/17 / #20170239176

Multilayer polymeric matrix based medical devices

The disclosure relates to multilayer polymeric matrix based medical devices. In one example, a device comprises an inner first polymeric matrix and an outer second polymeric matrix. The addition of second polymeric matrix modifies bulk properties of each matrix thus resulting in a device where specific bulk properties are incorporated.... The Regents Of The University Of Colorado A Body Corporate

08/24/17 / #20170240615

Compositions of, and methods for, alpha-1 antitrypsin fc fusion molecules

A novel method of treating and preventing bacterial diseases is provided. In particular, the present invention relates to compositions and methods for inhibition of Gram negative, Gram positive and acid fast bacilli in general and tuberculosis (TB), mycobacterium avium complex (MAC), and anthrax in particular. Thus, the invention relates to... The Regents Of The University Of Colorado A Body Corporate

08/17/17 / #20170232143

Covalently cross linked hydrogels and methods of making and using same

A thiol-yne polymeric material and methods for producing said polymers are disclosed. The material is produced by the radically mediated polymerization of monomers having alkyne and thiol functional groups. The alkyne moiety, internal or terminal, may react with one or two thiols. Degradable monomers may be used to form degradable... The Regents Of The University Of Colorado A Body Corporate

08/17/17 / #20170237119

Li-ion electrolyte membrane facilitated by a self-healing polymer matrix, and associated battery

Disclosed herein are compositions and methods of making novel covalently cross-linked polyimines that are non-malleable under standard conditions but yet may be rendered malleable. Also disclosed is an electrode having an electrolyte component mixed with a self-healing polyimine... The Regents Of The University Of Colorado A Body Corporate

08/10/17 / #20170224646

Composition and treating neurodegenerative disease

The present invention provides a method and composition for treating a neurodegenerative disease. In particular, the present invention provides a method and composition to increase DJ-1 gene expression or DJ-1 protein activity to treat a neurodegenerative disease.... The Regents Of The University Of Colorado A Body Corporate

08/10/17 / #20170224787

Compositions and methods for treatment of homocystinuria

Provided herein are improved compositions and methods for enzyme replacement therapy using modified human cystathionine beta synthase (CBS) in the treatment of homocystinuria and related diseases and disorders.... The Regents Of The University Of Colorado A Body Corporate

08/03/17 / #20170216097

Intraocular device for dual incisions

A microsurgical device and methods of its use can be used for treatment of various conditions including eye diseases, such as glaucoma, using minimally invasive surgical techniques. A dual-blade device can be used for cutting the trabecular meshwork (“TM”) in the eye. The device tip provides entry into the Schlemm's... The Regents Of The University Of Colorado A Body Corporate

08/03/17 / #20170218025

Bouvardin derivatives and therapeutic uses thereof

The present invention is directed at bouvardin analogs arid related compounds for the treatment of disorders including cancer. Provided herein are bouvardin analogs and related compounds, pharmaceutical compositions and kits comprising at least one bouvardin analog or related compound, and methods for treating disorders including cancer. In some aspects the... The Regents Of The University Of Colorado A Body Corporate

08/03/17 / #20170222393

Generation of vuv, euv, and x-ray light using vuv-uv-vis lasers

A method for extending and enhancing bright coherent high-order harmonic generation into the VUV-EUV-X-ray regions of the spectrum involves a way of accomplishing phase matching or effective phase matching of extreme upconversion of laser light at high conversion efficiency, approaching 10−3 in some spectral regions, and at significantly higher photon... The Regents Of The University Of Colorado A Body Corporate

07/27/17 / #20170209273

System and osteodistraction

Systems, devices, and methods for osteodistraction are provided. The systems and devices comprise ellipsoidal cams for providing controlled distraction of adjacent bone structures using a rotational force to produce displacement of the bone structures. An implantable distraction cam system is provided, along with instruments for achieving progressive osteodistraction with reduced... The Regents Of The University Of Colorado A Body Corporate

07/27/17 / #20170209549

Map44 polypeptides and constructs based on natural antibodies and uses thereof

The present invention provides delivery methods and constructs for treating inflammatory diseases in an individual. The targeted delivery approach utilizes an antibody that recognizes an epitope found to be present at sites of inflammation. The antibody is used to deliver a MAp44 polypeptide or fragment thereof to sites of inflammation,... The Regents Of The University Of Colorado A Body Corporate

07/27/17 / #20170209555

Compositions and methods for modulating cardiac conditions

Embodiments herein report methods and compositions for treating cardiac conditions. In certain embodiments, compositions and methods relate to reducing, inhibiting or treating a subject having or suspected of undergoing cardiac remodeling after a cardiac event. Other embodiments herein relate to compounds including naturally occurring and synthetic compositions of alpha-1 antitrypsin... The Regents Of The University Of Colorado A Body Corporate

07/20/17 / #20170202487

Diagnostic tool for measuring ossicular chain compliance

The disclosure provides systems and methods of use pertaining to precise measurements of middle ear mechanics to aid physicians in the determination of pre-operative, intraoperative, and post-repair stiffness of the ossicular chain to assist in the diagnosis and treatment and/or repair of all types of conductive hearing loss. One embodiment... The Regents Of The University Of Colorado A Body Corporate

07/20/17 / #20170204112

Anti-cancer compounds targeting ral gtpases and methods of using the same

Methods of inhibiting the growth or metastasis of a cancer in a subject by inhibiting a Ral GTPase in the subject, and small molecule inhibitors of Ral GTPases useful in the methods of the invention. Pharmaceutical compositions containing the compounds of the invention, and methods of using the same.... The Regents Of The University Of Colorado A Body Corporate

06/29/17 / #20170181892

Ophthalmic knife and methods of use

The present invention relates to an ophthalmic knife and methods of its use for treatment of various conditions including eye diseases, such as glaucoma, using minimally invasive surgical techniques. The invention relates to a multi-blade device for cutting the tissues within the eye, for example, a trabecular meshwork (TM).... The Regents Of The University Of Colorado A Body Corporate

06/29/17 / #20170183388

Methods, compositions, diagnostics and assays for the treatment of alzheimer's disease

The invention provides compounds for the treatment of Alzheimer's disease, methods for the use of such compounds, assays for the identification of such compounds, and methods for diagnosis of Alzheimer's disease and diagnostic kits. Methods of marketing compounds are also disclosed. In one aspect, the disclosure provides a compound for... The Regents Of The University Of Colorado A Body Corporate

06/15/17 / #20170166976

Dot1l inhibition in patients with mn1-high aml

The present disclosure relates to methods of treating AML associated with elevated levels of MN1 and HOXA9 expression by administering one or more DOT1L inhibitors and pharmaceutical compositions to subjects in need thereof.... The Regents Of The University Of Colorado A Body Corporate

05/25/17 / #20170145384

Carbon-nanotube modulation of myocyte cells

Embodiments include compositions of carbon nanotubes complexed with myocyte cells. Embodiments also include methods for making compositions of carbon nanotubes, and methods for modulating the electrophysical, proliferative, and viability potential of myocytes.... The Regents Of The University Of Colorado A Body Corporate

05/25/17 / #20170146262

Hybrid solar reactor and heat storage system

A hybrid solar reactor and a heat storage system are disclosed. The hybrid solar reactor includes one or more heaters and a solar light guide assembly coupled to a shell of the reactor. The solar light guide assembly includes a solar light guide to direct solar energy to, for example,... The Regents Of The University Of Colorado A Body Corporate

05/11/17 / #20170129929

Ledgf peptides and formulations thereof for treatment of degenerative disorders

LEDGF peptides with anti-protein aggregation activity and methods of use are provided. The LEDGF peptides disclosed herein demonstrate an ability to treat degenerative diseases and diseases with various cellular stresses including oxidative stress and protein-aggregation stress. In addition, extended release formulations, including formulations suitable for ophthalmic administration are provided.... The Regents Of The University Of Colorado A Body Corporate

05/11/17 / #20170131266

Binding detection using liquid crystal

The present invention provides methods, devices and kits for detecting binding between two molecules using a liquid crystal.... The Regents Of The University Of Colorado A Body Corporate

05/04/17 / #20170125656

Phononic metamaterials comprising atomically disordered resonators

Phononic metamaterials and methods for reducing the group velocities and the thermal conductivity in at least partially crystalline base material are provided, such as for thermoelectric energy conversion. In one implementation, a method for reducing thermal conductivity through an at least partially crystalline base material is provided. In another implementation,... The Regents Of The University Of Colorado A Body Corporate

05/04/17 / #20170119521

Modular intraocular lens designs, tools and methods

Modular IOL systems including a base and a lens, wherein the lens includes tabs for connection to the base. The modular IOL allows for the lens to be adjusted or exchanged while leaving the base in place, either intra-operatively or post-operatively.... The Regents Of The University Of Colorado A Body Corporate

04/27/17 / #20170114415

Activating ntrk1 gene fusions predictive of kinase inhibitor therapy

Disclosed are markers, methods and assay systems for the identification of patients suspected of having cancer and/or cancer patients who are predicted to respond, or not respond to the therapeutic administration of specific chemotherapeutic regimens. Particularly, the invention provides a testing paradigm based on tumor cell samples to select cancer... The Regents Of The University Of Colorado A Body Corporate

04/27/17 / #20170117556

Corrosion-resistant catalyst

A method for forming a corrosion-resistant catalyst for fuel cell catalyst layers is provided. The method includes a step of depositing a conformal Pt or platinum alloy thin layer on NbO2 substrate particles to form Pt-coated NbO2. The Pt-coated NbO2 particles are then incorporated into a fuel cell catalyst layer.... The Regents Of The University Of Colorado A Body Corporate

Patent Packs
04/20/17 / #20170108514

Diagnosis of multiple sclerosis in human and animal subjects

Cellular markers useful for methods of diagnosing multiple sclerosis (MS), relapse of MS patients and disease progression in MS patients, as well as identifying treatments for and monitoring treatment of patients with multiple sclerosis (MS). Methods of differential diagnosis of patients presenting with clinically isolated syndrome (CIS) suggestive of MS... The Regents Of The University Of Colorado A Body Corporate

03/30/17 / #20170087132

Treatment of breast cancer

This disclosure describes the use of one or more compounds that fall within the scope of one or more structural formula I, II, III, IV, V, or VI for treating triple negative breast cancer. Compounds useful for treating breast cancer include those compounds of formulae I, II, III, IV, V,... The Regents Of The University Of Colorado A Body Corporate

03/30/17 / #20170087171

Methods for treatment of vascular endothelial dysfunction using nicotinamide mononucleotide

This invention is about the compositions and methods for assessing and treating vascular endothelial dysfunction. Various aspects provide a method for treatment of vascular endothelial dysfunction, comprising administering a composition comprising nicotinamide mononucleotide and a pharmaceutical excipient to a subject. In one embodiment the dose is administered to subjects in... The Regents Of The University Of Colorado A Body Corporate

03/23/17 / #20170081343

Heterocyclic hydroxamic acids as protein deacetylase inhibitors and dual protein deacetylase-protein kinase inhibitors and methods of use thereof

The present invention relates to novel hydroxamic acids which are specific histone deacetylase (HDAC) inhibitors and/or TTK/Mps1 kinase inhibitors, including pharmaceutically acceptable salts thereof, which are useful for modulating HDAC and/or TTK/Mps1 kinase activity, pharmaceutical compositions comprising these compounds, and processes for their preparation.... The Regents Of The University Of Colorado A Body Corporate

03/23/17 / #20170081722

Polymorphisms in the pde3a gene

Embodiments of the invention are directed to identifying or treating a patient that would benefit from phosphodiesterase inhibitor therapy.... The Regents Of The University Of Colorado A Body Corporate

03/16/17 / #20170071464

Minimally-invasive measurement of esophageal inflammation

The methods and apparatus of the present invention allow the evaluation of inflammation of the esophagus. Measurements may be utilized, for example, to diagnose a disease of the esophagus, to monitor inflammation of the esophagus, or to access the treatment of a disease of the esophagus. In one embodiment, the... The Regents Of The University Of Colorado A Body Corporate

03/09/17 / #20170065687

Chemically modified cystathionine beta-synthase enzyme for treatment of homocystinuria

The invention provides reagents and methods for enzyme replacement therapy using chemically modified species of human cystathionine β-synthase (CBS) to treat homocystinuria and other related diseases and disorders.... The Regents Of The University Of Colorado A Body Corporate

03/09/17 / #20170065707

Compositions, methods and uses for thermally stable human papillomavirus formulations

Embodiments of the present invention provide for novel compositions and methods for making and using a thermally stable human papilloma virus (HPV) formulation or other stabilized multimeric virus formulation. Certain embodiments concern lyophilizing HPV formulations in the presence or absence of adjuvants. Other embodiments concern lypophilizing HPV capsomere vaccines in... The Regents Of The University Of Colorado A Body Corporate

03/09/17 / #20170067046

Compositions, methods and uses for multiplex protein sequence activity relationship mapping

Embodiments herein concern systems, compositions, methods and uses for in vivo selection of optimum target proteins of use in designing genomically-engineered cells or organisms. Some embodiments relate to compositions and methods for generating barcoded constructs of use in systems and methods described.... The Regents Of The University Of Colorado A Body Corporate

03/02/17 / #20170058360

Methods for prediction of clinical response to radiation therapy in cancer patients

Disclosed are biomarkers, methods and assay systems for the identification of cancer patients who are predicted to respond, or not respond to the therapeutic administration of radiation therapy to treat cancer. Thus, the invention provides a diagnostic paradigm to select cancer patients who will benefit from radiation therapy. In particular,... The Regents Of The University Of Colorado A Body Corporate

02/23/17 / #20170049619

Nasolacrimal implants and related methods for tear stimulation

A device for inducing production of tears may include a body extending from a proximal end to a distal end. The body may be configured for insertion through a puncta of a subject. The device also may include a stimulus delivery mechanism positioned between the proximal end and the distal... The Regents Of The University Of Colorado A Body Corporate

02/16/17 / #20170047499

Phononic metamaterials

Phononic metamaterials and methods for reducing thermal conductivity in at least partially crystalline base material are provided, such as for thermoelectric energy conversion. In one implementation, a method for reducing thermal conductivity through an at least partially crystalline base material is provided. In another implementation, a phononic metamaterial structure is... The Regents Of The University Of Colorado A Body Corporate

02/16/17 / #20170042960

Compositions and methods for treating hepatitis b

The present invention provides compositions and methods for treating hepatitis B virus (HBV) infection as well as methods for identifying a compound or a composition that is suitable for treating HBV infection. In addition, the present invention provides a suitable non-mammalian animal model that can be used to screen for... The Regents Of The University Of Colorado A Body Corporate

02/09/17 / #20170035867

Yeast-based immunotherapy and type i interferon sensitivity

Disclosed are methods of treating individuals with yeast-based immunotherapy who have been preselected as being sensitive to type I interferons, as well as methods for selecting individuals for treatment with yeast-based immunotherapeutic compositions and methods for enhancing or improving an individual's response to yeast-based immunotherapy, based on the individual's sensitivity... The Regents Of The University Of Colorado A Body Corporate

02/02/17 / #20170029901

Methods for prediction of clinical outcome to epidermal growth factor receptor inhibitors by cancer patients

Disclosed are biomarkers, methods and assay kits for the identification of cancer patients who are predicted to benefit, or not to benefit, from the therapeutic administration of an epidermal growth factor receptor (EGFR) inhibitor. The biomarkers of the present invention include detection of EGFR and HER 2 gene amplification and... The Regents Of The University Of Colorado A Body Corporate

Patent Packs
02/02/17 / #20170031151

Scanning imaging for encoded psf identification and light field imaging

Scanned illumination allows for capturing 3-dimensional information about an object. A conventional reflection (or transmission) bright field (or fluorescence, darkfield, polarizing, phase contrast or interference) microscope is configured to use laterally scanned illumination (for example by moving an array in front of the light source) to scan an extended object.... The Regents Of The University Of Colorado A Body Corporate

01/26/17 / #20170026301

Stateless network functions

Systems and methods are described for stateless network function virtualization. Embodiments operate in context of a data network, in which network middleboxes are virtualized, for example, for added scalability and fault tolerance. The virtualized middleboxes can implement state-reliant network functions in a manner that decouples the state from the packet... The Regents Of The University Of Colorado A Body Corporate

01/19/17 / #20170014479

Therapeutic applications of smad7

The invention provides methods and compositions for the treatment of inflammatory and/or tissue damage conditions. In particular, the use of Smad7 compositions delivered locally or systematically to a site of inflammation and/or tissue damage is described. Other specific embodiments concern treatment or prevention of side effects caused by radiation and/or... The Regents Of The University Of Colorado A Body Corporate

01/19/17 / #20170015667

Thiol-x click foldamers for polymer affinity and catalysis libraries

wherein independently Y and Z are atoms having a valence electrons of 3 or more; n is a integer from 0-10; m is a integer from 0-10; x is a integer from 0-10; PFS is a functional group SFSi; SFS2; and SFS3 are independently a combination of hydrogen, hydroxyl, aromatic,... The Regents Of The University Of Colorado A Body Corporate

01/19/17 / #20170015731

Compositions and methods for preparing a subject for organ or non-organ implantation

Embodiments of the present invention illustrate methods of preventing transplantation rejection. In certain embodiments, a subject in need of an organ or non-organ transplantation can be pretreated with an AAT composition to reduce the incidence of transplantation rejection in the subject. Other embodiments include treating a subject with a composition... The Regents Of The University Of Colorado A Body Corporate

01/12/17 / #20170007139

Statistical, noninvasive measurement of intracranial pressure

... The Regents Of The University Of Colorado A Body Corporate

01/12/17 / #20170009283

Multiplexed linking pcr

The invention provides compositions and methods for rapid assembly of one or more assembled polynucleotides from a plurality of component polynucleotides, as well as methods of designing polynucleotide primer and linker sets useful in the assembly methods of the invention.... The Regents Of The University Of Colorado A Body Corporate

01/12/17 / #20170010456

Optical imaging devices and variable-focus lens elements, and methods for using them

The present disclosure relates optical imaging devices and methods useful in biological and medical imaging applications. In one embodiment, an optical imaging device includes a flexible lightguide having a first end and a second end, the output of the source of pulsed infrared radiation being optically coupled to the first... The Regents Of The University Of Colorado A Body Corporate

01/05/17 / #20170000851

Ptd-smad7 therapeutics

The present technology provides methods and compositions for the treatment of inflammatory and/or tissue damage conditions. In particular, the use of Smad7 compositions delivered locally or systemically to a site of inflammation and/or tissue damage is described. Other specific embodiments concern treatment or prevention of side effects caused by radiation... The Regents Of The University Of Colorado A Body Corporate








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