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The Trustees Of Boston University patents


Recent patent applications related to The Trustees Of Boston University. The Trustees Of Boston University is listed as an Agent/Assignee. Note: The Trustees Of Boston University may have other listings under different names/spellings. We're not affiliated with The Trustees Of Boston University, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "T" | The Trustees Of Boston University-related inventors


 new patent  Cis/trans riboregulators

The present invention provides nucleic acid molecules, dna constructs, plasmids, and methods for post-transcriptional regulation of gene expression using rna molecules to both repress and activate translation of an open reading frame. Repression of gene expression is achieved through the presence of a regulatory nucleic acid element (the cis-repressive rna or crrna) within the 5′ untranslated region (5′ utr) of an mrna molecule. ... The Trustees Of Boston University

Sers system employing nanoparticle cluster arrays with multiscale signal enhancement

Defined nanoparticle cluster arrays (ncas) with dimensions up to 25.4 μm square are fabricated on a 10 nm gold film using template guided self-assembly. Structural parameters are precisely controlled, allowing systematic variation of the number of nanoparticles in the clusters (n) and edge to edge separation (∧) between 1<n<20 and 50 nm≤∧≤1000 nm, respectively. ... The Trustees Of Boston University

Infusion system and components thereof

Certain embodiments provide multi-medicament infusion systems for preventing the cross-channeling of medicaments. The system may include one or more of an infusion pump, medicament reservoirs, collars, a multi-channel fluid conduit, and an infusion set. ... The Trustees Of Boston University

Low-dimensional real-time concatenative speech synthesizer

A method of providing real-time speech synthesis based on user input includes presenting a graphical user interface having a low-dimensional representation of a multidimensional phoneme space, a first dimension representing degree of vocal tract constriction and voicing, a second dimension representing location in a vocal tract. One example employs a disk-shaped layout. ... The Trustees Of Boston University

Injectable tissue supplement

The present invention provides polymers which can be used as tissue supplements or lubricants in vivo. The inventive polymers can be used as tissue-interpenetrating hydrogel supplements, viscosupplements, tribosupplements, viscoelastics, tissue space fillers, and/or anti-adhesive agents. ... The Trustees Of Boston University

Method and device for antibiotic susceptibility testing based on fluctuations of electrical resistance in a microchannel

A system and method for antibiotic susceptibility testing efficiently determines whether bacteria are alive or have been killed by antibiotic treatment. The antibiotic susceptibility testing device includes at least one reservoir into which a bacteria solution is introduced and a microfluidic channel connected to the reservoir, wherein the cross-sectional size of the microfluidic channel is selected to be comparable to the size of the bacterium to be tested. ... The Trustees Of Boston University

Inhibitors of late sv40 factor (lsf) as cancer chemotherapeutics

The present invention is directed to methods, compositions and kits for treatment of cancer, e.g. Heptacellular carcinoma. ... The Trustees Of Boston University

Age-associated clonal hematopoiesis accelerates cardio-metabolic disease development

As demonstrated herein, a preferential and progressive expansion of a subset of hematopoietic cells bearing somatic mutations in tet2 leads to pro-inflammatory il-1β signaling at multiple levels, including increased il-1β transcription, increased nlrp3 inflammasome-mediated il-1β secretion, and increased il-1-receptor 1-mediated il-1β signaling. Accordingly, provided herein are compositions, methods, and assays for modulating tet2 mutation-mediated il-1β (interleukin-1β) proinflammatory activity, particularly when caused by somatic mutations in tet2.. ... The Trustees Of Boston University

Theranostic compositions and uses thereof

Provided herein are theranostic compositions comprising a janus nanoparticle-coated microbubble that are useful for imaging (e.g., mri, or ultrasound) and for delivering a therapeutic or bioactive agent (e.g., nucleic acid(s), drugs, etc), among other uses.. . ... The Trustees Of Boston University

Nanoparticle deposition in porous and on planar substrates

A method of preparing a metal nanoparticle on a surface includes subjecting a metal source to a temperature and a pressure in a carrier gas selected to provide a vapor metal species at a vapor pressure in the range of about 10−4 to about 10−11 atm; contacting the vapor metal species with a heated substrate; and depositing the metal as a nanoparticle on the substrate.. . ... The Trustees Of Boston University

Gene expression-based biomarker for the detection and monitoring of bronchial premalignant lesions

Disclosed herein are assays and methods for the identification of premalignant lesions, as well as methods of determining the likelihood that such premalignant lesions will progress to lung cancer. Also disclosed are methods and assays that are useful for monitoring the progression of premalignant lesions to lung cancer. ... The Trustees Of Boston University

Method and composition for reducing nitrates, nitrites, and/or hydroxylamine in water using a homogeneous reduced copper tetra-substituted fluorinated pinacolate ligand catalyst complex

A method for reducing nitrates, nitrites, and/or hydroxylamine in water using a homogeneous reduced copper tetra-substituted fluorinated pinacolate ligand catalyst complex. The method includes dissolving a copper(ii) tetra-substituted fluorinated pinacolate ligand pre-catalyst complex in water having an excess amount of nitrates, nitrites, and/or hydroxylamine therein. ... The Trustees Of Boston University

Wireless fluidic readout platform for sensors

Near-field magnetic resonance is used to retrieve information stored in sensors passing through a fluidic channel in a fluidic medium, and can also be used for recharging a power source in the sensors. The sensors have been previously injected into a downhole and/or reservoir environment, and are then retrieved in order to access the information the sensors have obtained by measuring physical and/or chemical properties of the downhole and/or reservoir.. ... The Trustees Of Boston University

Glycerol-based polycarbonates

The invention provides polymer compositions, compounds, processes, and methods of use of the polymers for drug delivery, biodegradable consumer plastics, or solvents for li-based batteries or supercapacitors. The invention is based, at least in part, on the discovery that poly(glyceric acid carbonate)s and alkyl functionalized poly(1,2 glycerol carbonates) and poly(glyceric acid carbonate)s and pharmaceutical agent/composition functionalized poly(1,2 glycerol carbonates) and poly(glyceric acid carbonate)s represent a new type of glycerol based polymer that 1) degrade into glycerol and carbon dioxide; 2) the poly(1,2 glycerol carbonates) degrade more readily than conventional poly(1,3 glycerol carbonates; and 3) poly(1,2 glycerol carbonates) can be processed to give melts, viscous fluids, liquids, films, sheets, gels, meshes, foams, fibers, or particles.. ... The Trustees Of Boston University

12/21/17 / #20170363582

Method and system for oblique backscattering ultrasound imaging

An oblique backscatter ultrasound imaging system includes a transceiver that has an us source and a plurality of us detectors configured in receive signals off axis from the us source. While the system is arranged in a reflective configuration, the device produces transmissive contrast signals to yield improved images. ... The Trustees Of Boston University

12/14/17 / #20170357853

Large scale video search using queries that define relationships between objects

One embodiment of the present solution is a relationship-based video server system. The server system is programmed to provide a platform for large scale video search based on relationships between objects in video segments, and the platform executes search based on probabilistically discriminative objects and relationships.. ... The Trustees Of Boston University

11/30/17 / #20170346088

Electrode comprising heavily-doped ceria

An electrode can include a functional layer having an ln2mo4 phase, where ln is at least one lanthanide optionally doped with a metal and m is at least one 3d transition metal, and a heavily-doped ceria phase. An electrochemical device or a sensor device can include the electrode.. ... The Trustees Of Boston University

11/16/17 / #20170328908

Diagnostic and prognostic methods for lung disorders using gene expression profiles from nose epithelial cells

The present invention provides methods for diagnosis and prognosis of lung cancer using expression analysis of one or more groups of genes, and a combination of expression analysis from a nasal epithelial cell sample. The methods of the invention provide far less invasive method with a superior detection accuracy for lung cancer when compared to any other currently available method for lung cancer diagnostic or prognosis. ... The Trustees Of Boston University

09/28/17 / #20170274075

Therapeutic and research application of pdcl3

Described herein are novel compositions comprising, for example, pdcl3 polypeptides having vegfr-2 inhibitory activity, inhibitory pdcl3 antibodies and pdcl3-binding fragments thereof, or pdcl3 inhibitory nucleic acid molecules, and methods of their use in anti-angiogenesis and anti-tumor proliferation and invasiveness therapies, such as the treatment of cancer, as well as the treatment of those vascular diseases where pathological angiogenesis plays a role, such as in carotid artery disease, macular degeneration, and plaque neovascularization. Also described herein are novel compositions comprising engineered pdcl3 polypeptides having enhanced chaperone activity, recombinant cells comprising such engineered pdcl3 polypeptides having enhanced chaperone activity, and methods thereof for therapeutic protein production and in vitro protein synthesis.. ... The Trustees Of Boston University

08/17/17 / #20170234801

Structured substrates for optical surface profiling

This disclosure provides methods and devices for the label-free detection of target molecules of interest. The principles of the disclosure are particularly applicable to the detection of biological molecules (e.g., dna, rna, and protein) using tandard sio2-based microarray technology.. ... The Trustees Of Boston University

08/10/17 / #20170226591

Detection methods for disorders of the lung

The present invention is directed to prognostic and diagnostic methods to assess lung disease risk caused by airway pollutants by analyzing expression of one or more genes belonging to the airway transcriptome provided herein. Based on the finding of a so called “field defect” affecting the airways, the invention further provides a minimally invasive sample procurement method in combination with the gene expression-based tools for the diagnosis and prognosis of diseases of the lung, particularly diagnosis and prognosis of lung cancer.. ... The Trustees Of Boston University

07/20/17 / #20170204477

Compositions comprising riboregulators and methods of use thereof

The invention provides novel and versatile classes of riboregulators, including inter alia activating and repressing riboregulators, switches, and trigger and sink rna, and methods of their use for detecting rnas in a sample such as a well and in modulating protein synthesis and expression.. . ... The Trustees Of Boston University

07/13/17 / #20170200865

Ultraviolet light emitting diodes

The invention provides ultraviolet (uv) light-emitting diodes (leds). The uv leds can comprise abase layer including p-type sic or p-type algan, an active layer, and an n-algan layer, wherein the active layer is disposed between the base layer and the n-algan layer. ... The Trustees Of Boston University

07/13/17 / #20170198346

Chemical functionalization of solid-state nanopores and nanopore arrays and applications thereof

Chemical functionalization of solid-state nanopores and nanopore arrays and applications thereof. Nanopores are extremely sensitive single-molecule sensors. ... The Trustees Of Boston University

07/06/17 / #20170190778

Inhibitors of fibroproliferative disorders and cancer

The present invention generally relates to the field of treatment of fibroproliferative diseases and disorders and cancer. Embodiments of the present invention generally relate to compositions, methods and kits comprising an inhibitor of a portion of the n-terminal pro-fibrotic domain (pfd) of aortic carboxypeptidase-like protein (aclp), and in some embodiments, in combination with an inhibitor of the discoidin (ds) domain of aclp, for use in methods for the treatment of fibroproliferative diseases and cancer, and inhibition of aclp-mediated activation of a member of the tgfβ receptor superfamily.. ... The Trustees Of Boston University

06/29/17 / #20170183654

Dna recombinase circuits for logical control of gene expression

The invention provides, inter alia, recombinase-based systems that provide for integrated logic and memory in living cells such as mammalian cells. The nucleic acid cassettes, switches, and systems described herein allow for control of gene expression or gene regulation. ... The Trustees Of Boston University

06/29/17 / #20170181495

Method and apparatus to assist foot motion about the pronation axis

An apparatus that assists foot movement includes a normally twisted plate configured to interact with the foot. The foot has a pronation axis, and the normally twisted plate is biased and configured to twist about a plate axis that substantially approximates the pronation axis in response to a load received from the foot during foot pronation. ... The Trustees Of Boston University

06/22/17 / #20170175111

Riboregulator compositions and methods of use

The invention provides novel and versatile classes of riboregulators, including inter alia activating and repressing riboregulators, switches, and trigger and sink rna, and methods of their use for detecting rnas in a sample such as a well and in modulating protein synthesis and expression.. . ... The Trustees Of Boston University

06/15/17 / #20170165486

System and method for neuro-stimulation

A neuro-stimulation system employs a includes a stimulator which may include electrode devices and/or vibration elements. A controller may be employed to drive the stimulating elements with an electrical signal. ... The Trustees Of Boston University

05/11/17 / #20170131148

Detection of electromagnetic radiation using nonlinear materials

An apparatus for detecting electromagnetic radiation within a target frequency range is provided. The apparatus includes a substrate and one or more resonator structures disposed on the substrate. ... The Trustees Of Boston University

05/04/17 / #20170119805

Proton-motive force stimulation to potentiate aminoglycoside antibiotics against persistent bacteria

Provided herein are compositions and methods to improve treatment of chronic infections, and reduce, delay, or inhibit formation of biofilms, using specific combinations of aminoglycoside antibiotics and high, localized concentrations of one or more pmf stimulating compounds. These novel methods are easily adapted to clinical settings as toxicity and efficacy of the antibiotics and metabolites used have already been studied in vivo, and as dosing for both the antibiotics and metabolites are known. ... The Trustees Of Boston University

04/20/17 / #20170107227

Inhibitors of late sv40 factor (lsf) as cancer chemotherapeutics

The present invention is directed to methods, compositions and kits for treatment of cancer, e.g. Heptacellular carcinoma. ... The Trustees Of Boston University

03/16/17 / #20170077329

Dark current mitigation with diffusion control

A photosensor device for reducing dark current is disclosed. The photosensor device includes a photon absorbing layer and two or more photosensor diffusions in said absorbing layer. ... The Trustees Of Boston University

03/09/17 / #20170070298

System and method for embedding phase and amplitude into a real-valued unipolar signal

A system for embedding phase and amplitude into a real valued unipolar signal suitable for intensity modulation (im) by optical transmitters. The system includes a complex-to-unipolar conversion engine configured to receive complex symbols in cartesian format and convert the complex symbols from the cartesian format to a polar coordinate format and generate real valued unipolar symbols including embedded phase and amplitude information of complex symbols in the cartesian format.. ... The Trustees Of Boston University

03/02/17 / #20170058036

Anti-despr monoclonal antibody targeted therapy and imaging for cancer and stroke

Provided herein are novel compositions comprising anti-despr antibodies and fragments thereof derived from 6g8g7 and 7c5b2 anti-despr variant antibodies, including fully human, composite engineered human, humanized, monoclonal, and polyclonal anti-despr antibodies and fragments thereof, and methods of their use in a variety of therapeutic applications. The compositions comprising the anti-despr antibodies and fragments thereof described herein are useful in diagnostic and imaging methods, such as despr-targeted molecular imaging of angiogenesis, and for companion diagnostic and/or in vivo non-invasive imaging and/or assessments.. ... The Trustees Of Boston University

02/16/17 / #20170044175

Inhibitors of late sv40 factor (lsf) as cancer chemotherapeutics

The present invention is directed to methods, compositions and kits for treatment of cancer, e.g. Heptacellular carcinoma. ... The Trustees Of Boston University

02/16/17 / #20170042898

Methods and compositions for treating viral or virally-induced conditions

Provided are methods and compositions for the prevention and/or treatment of viral conditions, virally-induced conditions and inflammatory conditions. The methods can comprise administering to a subject a viral inducing agent with an antiviral agent, and optionally an additional agent. ... The Trustees Of Boston University

02/16/17 / #20170042824

Gm3 functionalized nanoparticles

Embodiments disclosed herein relates to ganglioside gm3-containing mixed lipids nanoparticles having an overall size between 60-100 nm, the making thereof and the uses. The nanoparticles selectively targeted to cd169+ expressing cells such as dendritic cells and macrophage. ... The Trustees Of Boston University

02/02/17 / #20170029904

Classification of myc-driven b-cell lymphomas

Methods for diagnosing burkitt lymphoma (bl) and diffuse large b-cell lymphoma (dlbcl) based on a diagnostic score, as well as determining myc activity levels and selecting treatments based on a myc activity score.. . ... The Trustees Of Boston University

01/19/17 / #20170016821

Polarization enhanced interferometric imaging

An imaging system uses polarized light to illuminate the target and then uses a polarization filter to remove the light that is reflected from the target without modification. The target can include one or more anisotropic objects that scatter the light and alter the polarization state of the reflected light and causing it to be selectively transmitted to the imaging device which can record the transmitted light through the filter. ... The Trustees Of Boston University

01/12/17 / #20170007824

Minimally invasive splaying microfiber electrode array and methods of fabricating and implanting the same

An electrode array having a splayable bundle of fibers having heat-sharpened tips. A method of manufacturing an electrode array including heat-sharpening a tip of each of a plurality of fibers; and bundling the plurality of fibers. ... The Trustees Of Boston University








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