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The Trustees Of Columbia University In The City Of New York
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The Trustees Of Columbia University In The City Of New York patents


Recent patent applications related to The Trustees Of Columbia University In The City Of New York. The Trustees Of Columbia University In The City Of New York is listed as an Agent/Assignee. Note: The Trustees Of Columbia University In The City Of New York may have other listings under different names/spellings. We're not affiliated with The Trustees Of Columbia University In The City Of New York, we're just tracking patents.

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 new patent  Ancestral proteins

The invention provides a method tar increasing the stability and/or activity of a polypeptide at low pH and/or elevated temperatures The invention farther provides a method for increasing the melting temperature of a polypeptide. Also provided are paleoenzymologically reconstructed thioredoxin polypeptides having activity at higher temperatures and/or lower pH than... The Trustees Of Columbia University In The City Of New York

 new patent  Laser irradiation induced surface planarization of polycrystalline silicon films

A method for planarizing excimer laser annealed (ELA) poly-crystalline thing films via irradiation. The method includes providing an ELA thin film having an oxide and a top surface with a first surface roughness defined at least by a first plurality of protrusions. The ELA thin film is etched to substantially... The Trustees Of Columbia University In The City Of New York

Methods for altering polypeptide expression

The invention is directed to methods and metric suitable for use in modulating the expression of a polypeptide encoded by a nucleic acid sequence. In certain aspects, the invention also relates to methods for introducing modifications in a polypeptide, for example through substitution of one or more nucleic acids in... The Trustees Of Columbia University In The City Of New York

Compositions and methods for inhibiting tumor cells by inhibiting the transcription factor atf5

The present invention relates to methods for treating and/or preventing tumors and/or promoting apoptosis in a neoplastic cell comprising contacting the neoplastic cell with an cell-penetrating dominant-negative ATF5 (“CP-d/n-ATF5”), wherein the CP-d/n-ATF5 is capable of inhibiting ATF5 function and/or activity.... The Trustees Of Columbia University In The City Of New York

Bio-film resistant surfaces

The present invention relates to methods and compositions for rendering a surface resistant to bio-film formation by a combination of an antimicrobial agent, an organic hydroxy acid, lubricious biomedical polymer and solvent. The invention provides for compositions which may be used to render surfaces bio-film resistant, articles having bio-film resistant... The Trustees Of Columbia University In The City Of New York

Wearable ultrafiltration devices methods and systems

A wearable ultrafiltration apparatus is provided. The apparatus can include a first dialyzer for filtering a patient's blood along a first fluid path and a second dialyzer for filtering the patient's blood along a second fluid path. The apparatus can also include a valve being positionable in a first position... The Trustees Of Columbia University In The City Of New York

Map kinase modulators and uses thereof

The invention provides for novel MAP kinase inhibitors and compositions comprising the same. In some embodiments, the MAP kinase inhibitors are p38α MAP kinase inhibitors. The invention further provides for methods for treatment of diseases comprising administration of MAP kinase inhibitors or compositions comprising MAP kinase inhibitors. In some embodiments,... The Trustees Of Columbia University In The City Of New York

Methods of producing metal sulfides, metal selenides, and metal sulfides/selenides having controlled architectures using kinetic control

The present invention is directed to methods of preparing metal sulfide, metal selenide, or metal sulfide/selenide nanoparticles and the products derived therefrom. In various embodiments, the nanoparticles are derived from the reaction between precursor metal salts and certain sulfur- and/or selenium-containing precursors each independently having a structure of Formula (I),... The Trustees Of Columbia University In The City Of New York

Disruption of the interaction between amyloid beta peptide and dietary lipids

The present invention relates to methods of treating neurodegenerative disorders associated with Alzheimer's disease (AD), Parkinson's disease (PD) and synucleinopathies, such as dementia with Lewy bodies, Down Syndrome (DS) and associated cognitive disorders, multiple system atrophy, and rare neuroaxonal dystrophies, such as Niemann-Pick type C disease (NPC) and Gaucher's disease... The Trustees Of Columbia University In The City Of New York

High-sensitive swept-source optical coherence tomography system and methods of use thereof

An exemplary system can be provided which can include, for example, a plurality of source arrangements configured to provide a plurality of electro-magnetic radiations to at least one of at least one sample or at least one reference structure, a first arrangement configured to receive a first radiation(s) from the... The Trustees Of Columbia University In The City Of New York

Secured cyber-physical systems

Disclosed are devices, systems, apparatus, methods, products, and other implementations, including a method that includes causing at least one reset for one or more components of a cyber-physical system, the cyber-physical system including a mechanical apparatus with at least one of a mechanical input or a mechanical output, and at... The Trustees Of Columbia University In The City Of New York

Systems and methods for single-molecule detection using nanotubes

A method for single-molecule detection is provided and uses a carbon nanotube having a probe entity attached thereto to define a first state of the carbon nanotube. The carbon nanotube is introduced to a target entity to define a second state of the carbon nanotube. The electrical conductance of the... The Trustees Of Columbia University In The City Of New York

Graphene-based nanosensor for identifying target analytes

A microdevice for monitoring a target analyte is provided. The microdevice can include a field effect transistor comprising a substrate, a gate electrode, and a microfluidic channel including graphene. The microfluidic channel can be formed between drain electrodes and source electrodes on the substrate. The microdevice can also include at... The Trustees Of Columbia University In The City Of New York

Integrated micro-lens waveguide and methods of making and using same

A probe structure includes a monolithically integrated waveguide and lens. The probe is based on SU-8 as a guiding material. A waveguide mold is defined using wet etching of silicon using a silicon dioxide mask patterned with 45° angle with respect to the silicon substrate edge and an aluminum layer... The Trustees Of Columbia University In The City Of New York

Opioid receptor modulators

The present invention provides a compound having the structure wherein A is a ring structure, with or without substitution; X1 is C or N; X2 is N, O, or S; Y1 is H, -(alkyi), -(alkenyl), -(alkynyl), -(cycloalkyi), (haloalkyi), -(alkyl)-O-(alkyl) or -(alkyl)-(cycloalkyl); Y 2 is H, -(alkyi), -(alkenyl), -(alkynyl), -(cycloalkyi), (haloalkyi),... The Trustees Of Columbia University In The City Of New York

Engineering mechanically functional human cartilage and making same

Medical devices having engineered mechanically functional cartilage from adult human mesenchymal stem cells and method for making same.... The Trustees Of Columbia University In The City Of New York

Methods and systems for capturing and storing carbon dioxide

Methods and systems for capturing and storing carbon dioxide are disclosed. In some embodiments, the methods include the following: mixing materials including magnesium or calcium with one or more acids and chelating agents to form a magnesium or calcium-rich solvent; using the organic acids derived from biogenic wastes as acids... The Trustees Of Columbia University In The City Of New York

Osteochondroreticular stem cells for bone and cartilage regeneration

The invention is directed to osteochondroreticular stem cells and methods of using osteochondroreticular stem cells. In another aspect the invention is directed to a method of treating osteoarthritis or skeletal fractures using osteochondroreticular stem cells.... The Trustees Of Columbia University In The City Of New York

Detection of analytes using live cells

The present invention provides sensor cells comprising a receptor that binds to an analyte indicative of the presence of an agent, where binding of the analyte to the receptor triggers a detection event that is indicative of the presence of the agent. In certain embodiments, the detection event is appearance... The Trustees Of Columbia University In The City Of New York

Diagnosis and treatment of cancer expressing ilt3 or ilt3 ligand

The present invention relates to methods of using the expression of ILTL3 ligand or ILT3 on certain types of cancer cells as a diagnostic tool. Methods are provided for treating ILT3-ligand expressing cancers, such as T-cell acute lymphoblastic leukemia (T-cell acute lymphoblastic leukemia), for example by administering ILT3, the extracellular... The Trustees Of Columbia University In The City Of New York

Autism-associated biomarkers and uses thereof

The invention discloses biomarkers for human autism. The invention provides methods for treating, preventing, and diagnosing human autism and autism-related disorders.... The Trustees Of Columbia University In The City Of New York

Devices, methods, and systems for measuring elastic properties of biological tissues using acoustic force

A device, method, and system for using an acoustic radiation force resulting from focused ultrasound energy in order to generate an internal force remotely and to measure quantitatively tissue elasticity in vivo and non-invasively.... The Trustees Of Columbia University In The City Of New York

Aldose reductase inhibitors and uses thereof

The present invention relates to novel compounds and pharmaceutical compositions thereof, and methods for promoting healthy aging of skin, the treatment of skin disorders, the treatment of cardiovascular disorders, the treatment of renal disorders, the treatment of angiogenesis disorders, such as cancer, treatment of tissue damage, such as non-cardiac tissue... The Trustees Of Columbia University In The City Of New York

Osteocalcin as a treatment for frailty associated with aging

Methods and compositions for treating frailty in mammals, preferably humans, are provided. The methods generally involve modulation of the OST-PTP signaling pathway or the PTP-1B signaling pathway involving gamma-carboxylase and osteocalcin, e.g., by administration of undercarboxylated/uncarboxylated osteocalcin. The methods comprise alleviating at least one of: muscle wasting or a lung... The Trustees Of Columbia University In The City Of New York

Design and synthesis of cleavable fluorescent nucleotides as reversible terminators for dna sequencing by synthesis

This invention provides novel azido linkers for deoxynucleotide analogues having a detectable marker attached thereto.... The Trustees Of Columbia University In The City Of New York

Methods and compositions for treatment of glioblastoma

Techniques for treating a subject with M-GBM and recurrent GBM are provided. Example methods include obtaining at least two M-GBM tumor samples from different locations within a patient, extracting genomic DNA from each of the tumor samples, and determining whether the subject has a mutation in PI3K-AKT-mTOR (PAM) pathway in... The Trustees Of Columbia University In The City Of New York

Methods, media, and systems for detecting attack on a digital processing device

Methods, media, and systems for detecting attack are provided. In some embodiments, the methods include: comparing at least part of a document to a static detection model; determining whether attacking code is included in the document based on the comparison of the document to the static detection model; executing at... The Trustees Of Columbia University In The City Of New York

Massive parallel decoding dna and rna

This invention provides methods for attaching a nucleic acid to a solid surface and for sequencing nucleic acid by detecting the identity of each nucleotide analogue after the nucleotide analogue is incorporated into a growing strand of DNA in a polymerase reaction. The invention also provides nucleotide analogues which comprise... The Trustees Of Columbia University In The City Of New York

Systems and methods for cmos-integrated junction field effect transistors for dense and low-noise bioelectronic platforms

A complementary metal oxide semiconductor (CMOS)-integrated junction field effect transistor (JFET) has reduced scale and reduced noise. An exemplary JFET has a substrate layer of one dopant type with a gate layer of that dopant type disposed on the substrate, a depletion channel of a second dopant type disposed on... The Trustees Of Columbia University In The City Of New York

Wireless-transmitter circuits including power digital-to-amplitude converters

Circuits comprising: digital-to-amplitude converter (DAC), comprising: binary weighted switching transistors (BWSTs), each having gate coupled to amplitude control bit ACB, and wherein the drain of each of the BWSTs are connected together and wherein the source of each of the BWSTs are connected together; transistor M1 having gate coupled to... The Trustees Of Columbia University In The City Of New York

Mems-based calorimeter, fabrication, and use thereof

A MEMS-based calorimeter includes a reference channel, a sample channel, and a thermopile configured to measure a temperature differential between the reference channel and a sample channel. The reference channel and the sample channel each include a passive mixer such as a splitting-and-recombination micromixer. The passive mixer can be formed... The Trustees Of Columbia University In The City Of New York

Human notch1 decoys

Provided herein are Notch1 fusion proteins. These fusion proteins comprise consecutive amino acids the sequence of which, commencing at the N-terminus of the fusion protein, is identical to the sequence of the amino acids in an extracellular domain of a human Notch1 receptor protein and an Fc portion of an... The Trustees Of Columbia University In The City Of New York

Mems-based calorimeter, fabrication, and use thereof

A MEMS-based calorimeter includes a reference channel, a sample channel, and a thermopile configured to measure a temperature differential between the reference channel and a sample channel. The reference channel and the sample channel each include a passive mixer such as a splitting-and-recombination micromixer. The passive mixer can be formed... The Trustees Of Columbia University In The City Of New York

Method of making a personalized bone graft

An anatomically-shaped, human bone graft may be cultivated ex vivo using a bioreactor capable of perfusing large complex porous scaffolds. Scaffolds derived from image-based modeling of a target are seeded with human mesenchymal stem cells and cultivated. A bioreactor configured to house complex three-dimensional scaffold geometries provides controlled flow for... The Trustees Of Columbia University In The City Of New York

Akt and shh pathway inhibitor combination therapy for treating basal cell carcinomas

A mechanism whereby aberrant Shh signaling converges on the Akt1-mTOR pathway, conferring selective growth advantage and enhanced survival of tumor cells has been identified. Utilizing a mouse model of BCNS, a pivotal role has been discovered for Akt1 signaling in BCC tumorigenesis. Based on the results described here certain embodiments... The Trustees Of Columbia University In The City Of New York

10/12/17 / #20170294608

Self-assembled, electronically-functional nucleic acid nanostructures and networks based on the use of orthogonal base pairs

Methods and systems for engineering a nanostructure are provided. An exemplary method includes creating at least one cytosine-cytosine and/or thymine-thymine mismatch in at least one oligonucleotide sequence, placing a metal ion into the mismatch of the oligonucleotide sequence to form an electronically functionalized nanostructure, and inducing self-assembly of the oligonucleotide... The Trustees Of Columbia University In The City Of New York

10/12/17 / #20170294629

Light emission from electrically biased graphene

Methods and systems for emitting light from electrically biased graphene are provided. An exemplary method of generating a light emission from graphene includes suspending a graphene membrane using at least one mechanical clamp and providing a current to the graphene membrane to establish a source-drain bias voltage along the graphene... The Trustees Of Columbia University In The City Of New York

10/05/17 / #20170281772

A neural substrate for sugar preference

This invention concerns a composition and a method of modulating the craving and/or desire for natural sugar in a subject comprising: agonizing or stimulating or antagonizing or silencing a selective group of neurons in the cadual nucleus of the solitary tract (cNST) of the brain in the subject, whether directly... The Trustees Of Columbia University In The City Of New York

10/05/17 / #20170283451

Dna sequencing by synthesis using rama and ifrared spectroscopy detection

This invention provides a process of labeling a polynucleotide analogue to be detected by Raman and/or infrared spectroscopy detection.... The Trustees Of Columbia University In The City Of New York

10/05/17 / #20170283810

Nucleic acid constructs for presentation of cd4 and cd8 epitopes, cellular transfection and uses thereof

The invention relates to constructs, cells and methods for modulating the immune system that optimize presentation of CD4 and CD8 epitopes to antigen-presenting cells and transfection into cells. Epitopes to either self antigens or non-self antigens can be used to optimize either a tolerance or immunogenicity to those epitopes, respectively.... The Trustees Of Columbia University In The City Of New York

10/05/17 / #20170283859

Microfluidic qrt-pcr analysis of single cells

The disclosed subject matter provides a microdevice and techniques for single-cell gene expression profiling using a microfluidic device capable of cell-trapping, cell lysis, bead-based gene analysis. The microdevice can be capable of independent or parallelized, simultaneous quantitative genetic assays of single cells.... The Trustees Of Columbia University In The City Of New York

10/05/17 / #20170284787

Systems and methods for contact localization through spatially overlapping signals

Achieving high spatial resolution in contact sensing for robotic manipulation often comes at the price of increased complexity in fabrication and integration. One traditional approach is to fabricate a large number of taxels, each delivering an individual, isolated response to a stimulus. In contrast, proposed sensor includes a continuous volume... The Trustees Of Columbia University In The City Of New York

09/28/17 / #20170275585

Cellular response to surface with nanoscale heterogeneous rigidity

An elastomeric substrate comprises a surface with regions of heterogeneous rigidity, wherein the regions are formed by exposing the elastomeric substrate to an energy source to form the regions such that the regions include a rigidity pattern comprising spots.... The Trustees Of Columbia University In The City Of New York

09/28/17 / #20170277889

Systems, methods, and media for outputting a dataset based upon anomaly detection

Systems, methods, and media for outputting a dataset based upon anomaly detection are provided. In some embodiments, methods for outputting a dataset based upon anomaly detection: receive a training dataset having a plurality of n-grams, which plurality includes a first plurality of distinct training n-grams each being a first size;... The Trustees Of Columbia University In The City Of New York

09/28/17 / #20170279557

Resilient optical networking

An optical communication system includes a plurality of optical system nodes, a plurality of optical space switches and a plurality of optical fibers. The plurality of optical system nodes each includes at least one reconfigurable optical add/drop multiplexer (ROADM). The optical system nodes each have at least one client side... The Trustees Of Columbia University In The City Of New York

09/14/17 / #20170258786

Rbp4 antagonists for the treatment of age-related macular degeneration and stargardt disease

A method for treating a disease characterized by excessive lipofuscin accumulation in the retina in a mammal afflicted therewith, comprising administering to the mammal an effective amount of a compound having the structure of any one of Formulas I-IV described herein, or a pharmaceutically acceptable salt thereof.... The Trustees Of Columbia University In The City Of New York

09/14/17 / #20170264672

Methods, systems, and media for stored content distribution and access

Methods for distributing and providing access to stored content from remote storage comprising: receiving a first request to access a first portion of stored content from a requestor, wherein the first request is in a file system request format; creating a placeholder for the stored content so that the placeholder... The Trustees Of Columbia University In The City Of New York

09/14/17 / #20170260509

Systems, methods, and devices for cell cycle synchronization of stem cells

The present disclosure relates to methods and systems of tissue engineering, and, more particularly, to optimization of tissue regeneration using cell cycle synchronization of stem cells.... The Trustees Of Columbia University In The City Of New York

09/07/17 / #20170255258

Imperceptible automatic field-of-view restrictors to combat vr sickness and cybersickness

The present disclosure provides an eye-tracked field of view restrictor for a virtual reality, augmented reality, and/or mixed reality system that reduces the effects of virtual reality sickness and/or cybersickness. A field of view restrictor with a soft-edge, hard edge, or arbitrary dynamic aperture is utilized, and the aperture is... The Trustees Of Columbia University In The City Of New York

08/31/17 / #20170247327

Octahydrocyclopentapyrroles, their preparation and use

The present invention provides Octahydrocyclopentapyrrole compounds having the structure: (structurally represented) wherein psi is absent or present, and when present is a bond; R1, R2, R3, R4, and R5 are each independently H, halogen, CF, or C1-C4 alkyl; R6 is absent or present, and when present is H, OH, or... The Trustees Of Columbia University In The City Of New York

08/31/17 / #20170246173

Methods and pharmaceutical compositions for treating lymphoid malignancy

The present invention provides, inter alia, methods for treating, preventing, or ameliorating the effects of a lymphoid malignancy, such as those associated with a mutated phosphatase and tensin homolog (PTEN) gene, or T-cell acute lymphoblastic leukemia (T-ALL). These methods include administering to a subject an effective amount of a phosphoinositide... The Trustees Of Columbia University In The City Of New York

08/31/17 / #20170246267

Cholinergic antagonism as an adjunct to cancer therapy

The invention provides for methods for treating gastric cancer or colon cancer in a subject by administering a cholinergic antagonist, a Botulinum toxin, a NGF inhibitior, a TRK inhibitor, or performing a surgical denervation. The invention provides for inhibiting stem cells growth by administering a cholinergic antagonist, a Botulinum toxin,... The Trustees Of Columbia University In The City Of New York

08/31/17 / #20170246339

Novel hemostatic compositions and dressings for bleeding

The present invention provides hemostatic compositions comprising components of the flowers of pharmaceutical chamomile (Chamomilla recutita), the leaves of dioecious nettle (Urtica dioica), kaolin, chitosan, fibrinogen and thrombin. Further inclusion of a biocompatible polymeric base, particularly an alignate, generates a composition with superior and broad spectrum hemostatic capabilities, including the... The Trustees Of Columbia University In The City Of New York

08/31/17 / #20170250024

Rare-earth-free permanent magnetic materials based on fe-ni

The invention provides high coercivity magnetic materials based on FeNi alloys having an L10 phase structure, and methods for making the materials.... The Trustees Of Columbia University In The City Of New York

08/24/17 / #20170241948

Nucleic acid sequences using tags

This disclosure provides chips, systems and methods for sequencing a nucleic acid sample. Tagged nucleotides are provided into a reaction chamber comprising a nanopore in a membrane. An individual tagged nucleotide of the tagged nucleotides can contain a tag coupled to a nucleotide, which tag is detectable with the aid... The Trustees Of Columbia University In The City Of New York

08/24/17 / #20170240605

Compositions and methods for inhibiting tumor cells by inhibiting the transcription factor atf5

The present invention relates to methods for treating and/or preventing tumors and/or promoting apoptosis in a neoplastic cell comprising contacting the neoplastic cell with an cell-penetrating dominant-negative ATF5 (“CP-d/n-ATF5”), wherein the CP-d/n-ATF5 is capable of inhibiting ATF5 function and/or activity.... The Trustees Of Columbia University In The City Of New York

08/24/17 / #20170240606

Compositions and methods for inhibiting tumor cells by inhibiting the transcription factor atf5

The present invention relates to methods for treating and/or preventing tumors and/or promoting apoptosis in a neoplastic cell comprising contacting the neoplastic cell with an cell-penetrating dominant-negative ATF5 (“CP-d/n-ATF5”), wherein the CP-d/n-ATF5 is capable of inhibiting ATF5 function and/or activity.... The Trustees Of Columbia University In The City Of New York

08/24/17 / #20170243002

Detecting return-oriented programming payloads by evaluating data for a gadget address space address and determining whether operations associated with instructions beginning at the address indicate a return-oriented programming payload

Systems, methods, and media for detecting the presence of return-oriented programming (ROP) payloads are provided, comprising: identifying a potential gadget address space; determining if a piece of the data corresponds to an address of the potential gadget address space; and in response to determining that the piece of the data... The Trustees Of Columbia University In The City Of New York

08/24/17 / #20170245290

Method, computer-readable storage device, and allocating timeslots on channels in a wireless network

A method, computer-readable storage device, and apparatus for allocating a plurality of timeslots of each channel of a plurality of channels in a wireless network are disclosed. For example, the method determines a location and a velocity for each user endpoint device of a plurality of user endpoint devices, estimates... The Trustees Of Columbia University In The City Of New York

08/17/17 / #20170233370

Compounds, compositions, and methods for modulating ferroptosis and treating excitotoxic disorders

Also provided are compositions containing a pharmaceutically acceptable carrier and a compound according to the present invention. Further provided are methods for treating or ameliorating the effects of an excitotoxic disorder in a subject, methods of modulating ferroptosis in a subject, methods of reducing reactive oxygen species (ROS) in a... The Trustees Of Columbia University In The City Of New York

08/17/17 / #20170234816

Temperature sensor based on direct threshold-voltage sensing for on-chip dense thermal monitoring

Systems and methods for measuring a temperature dependency of a threshold voltage are provided. Disclosed systems can include a shared pre-charge P-type metal-oxide-semiconductor (PMOS) transister, configured to pre-charge an output node to a supply voltage. The system can further include a sensing PMOS transistor, electrically coupled to the shared pre-charge... The Trustees Of Columbia University In The City Of New York

08/10/17 / #20170226246

Cationic particles comprising cyclopropenium, their preparation and uses

Embodiments of the present invention provides compounds, compositions, and methods for their preparation or synthesis that provide polymer-based cationic particles, such as, e.g., polymer-nucleic acid complexes, for delivering molecules including biomolecules, which is particularly desirable in gene therapy. Inventive materials include positively-charged linear homopolymers and block copolymers by living free... The Trustees Of Columbia University In The City Of New York

08/10/17 / #20170226586

Methods for identifying subjects with a genetic risk for developing iga nephropathy

Seven protective alleles for IgA nephropathy have been discovered that can be identified by analyzing a DNA sample for seven respective SNPs. A method is provided for identifying and treating subjects at risk of developing IgA neuropathy based on a new seven-SNP genetic risk score. Also provided are screening methods... The Trustees Of Columbia University In The City Of New York

08/10/17 / #20170227537

Diagnostic devices, systems, and methods

Diagnostic systems, methods, and devices employing low-cost handheld components are disclosed herein. A diagnostic system can include a diagnostic device that is configured to perform one or more assays on a fluid sample, such as a whole blood sample, in one or more microfluidic channels or chambers. The diagnostic device... The Trustees Of Columbia University In The City Of New York

08/03/17 / #20170216292

Aldose reductase inhibitors and uses thereof

The present invention relates to novel compounds and pharmaceutical compositions thereof, and methods for promoting healthy aging of skin, the treatment of skin disorders, the treatment of cardiovascular disorders, the treatment of renal disorders, the treatment of angiogenesis disorders, such as cancer, treatment of tissue damage, such as non-cardiac tissue... The Trustees Of Columbia University In The City Of New York

Patent Packs
08/03/17 / #20170216275

Phosphodiesterase inhibitors and uses thereof

The invention provides for compounds that are phosphodiesterase inhibitors. The invention further provides for a method for screening compounds that bind to and modulate a phosphosdiesterase protein. The invention also provides methods for treating conditions associated with accumulated amyloid-beta peptide deposit accumulations by administering a phosphodiesterase-binding compound to a subject.... The Trustees Of Columbia University In The City Of New York

08/03/17 / #20170216291

Aldose reductase inhibitors and uses thereof

The present invention relates to novel compounds and pharmaceutical compositions thereof, and methods for promoting healthy aging of skin, the treatment of skin disorders, the treatment of cardiovascular disorders, the treatment of renal disorders, the treatment of angiogenesis disorders, such as cancer, treatment of tissue damage, such as non-cardiac tissue... The Trustees Of Columbia University In The City Of New York

08/03/17 / #20170217913

A new class of mu-opioid receptor agonists

or a pharmaceutically acceptable salt or ester thereof.... The Trustees Of Columbia University In The City Of New York

07/27/17 / #20170210759

Activators of autophagic flux and phospholipase d and clearance of protein aggregates including tau and treatment of proteinopathies

The present application discloses compounds which are activators of autophagic flux and pharmaceutical compositions comprising said activators. It further discloses use of said compounds and pharmaceutical compositions in the treatment of neurodegenerative diseases, particularly proteinopathies and tauopathies such as Alzheimer's disease. It further discloses methods of enhancing autophagic flux.... The Trustees Of Columbia University In The City Of New York

07/27/17 / #20170213350

Systems and methods for detecting motion using local phase information

Systems and methods for the detection of motion in a multi-dimensional signal are provided. According to aspects of the disclosure, data representing a time sequence of frames of a video stream is received. A multi-dimensional Gaussian window in is then constructed. Each frame of the received data is divided into... The Trustees Of Columbia University In The City Of New York

07/20/17 / #20170204375

Inhibition of serotonin expression in gut enteroendocrine cells results in conversion to insulin-positive cells

Disclosed herein are methods involving the targeting of 5HT biosynthesis in gut insulin-negative cells to convert them into insulin-positive cells. Also disclosed are methods for treating a disease or disorder in a mammal, preferably a human, associated with impaired pancreatic endocrine function, by administering a therapeutically effective amount of an... The Trustees Of Columbia University In The City Of New York

07/20/17 / #20170204375

Inhibition of serotonin expression in gut enteroendocrine cells results in conversion to insulin-positive cells

Disclosed herein are methods involving the targeting of 5HT biosynthesis in gut insulin-negative cells to convert them into insulin-positive cells. Also disclosed are methods for treating a disease or disorder in a mammal, preferably a human, associated with impaired pancreatic endocrine function, by administering a therapeutically effective amount of an... The Trustees Of Columbia University In The City Of New York

07/06/17 / #20170189482

Mutant ngal proteins and uses thereof

In one aspect the present invention is directed to mutant Neutrophil Gelatinase Associated Lipocalin (NGAL) proteins that have the ability to bind to siderophores, such as enterochelin, and to chelate and transport iron, and that are excreted in the urine. Such NGAL mutants, and complexes thereof with siderophores, can be... The Trustees Of Columbia University In The City Of New York

07/06/17 / #20170190730

Massive parallel decoding dna and rna

... The Trustees Of Columbia University In The City Of New York

07/06/17 / #20170190751

Mutant ngal proteins and uses thereof

In one aspect the present invention is directed to mutant NGAL proteins that have the ability to bind to siderophores, such as enterochelin, and to chelate and transport iron, and that are excreted in the urine. Such NGAL mutants, and complexes thereof with siderophores, can be used to clear excess... The Trustees Of Columbia University In The City Of New York

07/06/17 / #20170191035

Ex vivo browning of adipose tissue therapy for reversal of obesity and type ii diabetes

Provided are methods, apparatus, pharmaceutical compositions, and kits for treatment of a metabolic condition, including obesity and type 2 diabetes, by administration to a subject of a therapeutically effective amount of a cell or tissue preparation such as brown adipose microtissues or brown adipose tissue directly converted from white adipose... The Trustees Of Columbia University In The City Of New York

07/06/17 / #20170193199

Methods and systems for identifying a drug mechanism of action using network dysregulation

Techniques to identify a mechanism of action of a compound using network dysregulation are disclosed herein. An example method can include selecting at least a first interaction involving at least a first gene, determining a first n-dimensional probability density of gene expression levels for the first gene and one or... The Trustees Of Columbia University In The City Of New York

07/06/17 / #20170194920

Circuits for providing class-e power amplifiers

In some embodiments, circuits for providing Class-E power amplifiers are provided, the circuits comprising: a first switch having a first side and a second side; a first Class-E load network coupled to the first side of the first switch; a second Class-E load network; and a second switch having a... The Trustees Of Columbia University In The City Of New York

06/29/17 / #20170184612

Use of leukocytes and novel biomarkers in the diagnosis, confirmation, and treatment of a neurological disorder

The present invention provides methods for assessing whether a subject is at risk of developing a neurological disorder, diagnosing or confirming whether a subject is afflicted with a neurological disorder, assessing whether PD has progressed in a subject afflicted with PD, assessing whether a neurological disorder is developing in a... The Trustees Of Columbia University In The City Of New York

06/29/17 / #20170181669

Graphene-based nanosensor for identifying target analytes

A receptor capable of binding to the target analyte can be used in monitoring a target analyte in a bodily fluid or a sample. A microdevice in accordance with the disclosed subject matter can include a substrate and a conductance elements with receptors grafted on the surface of the conductance... The Trustees Of Columbia University In The City Of New York

Patent Packs
06/29/17 / #20170182054

Histone acetyltransferase activators and uses thereof

The invention provides compounds and compositions comprising compounds that modulate histone acyl transferase (HAT). The invention further provides methods for treating neurodegenerative disorders, conditions associated with accumulated amyloid-beta peptide deposits, Tau protein levels, and/or accumulations of alpha-synuclein as well as cancer by administering a compound that modulates HAT to a... The Trustees Of Columbia University In The City Of New York

06/29/17 / #20170182287

Introducer for accessing coronary sinus via right parasternal mediastinotomy

An introducer configured with a first curve having a first angle that traverses space of an atrial appendage, a central atrium, caudad to the coronary sinus, and a second curve that has an angle sufficient to align the introducer with an intrinsic curvature of the coronary sinus of a subject.... The Trustees Of Columbia University In The City Of New York

06/29/17 / #20170186961

Organic semiconductor compounds and methods of use

Organic perylene diimide-based compounds are provided. Methods of producing the organic compounds is also provided as well as methods of their use including, among other things, their use as organic semiconductor materials.... The Trustees Of Columbia University In The City Of New York

06/22/17 / #20170172569

Endovascular flexible stapling device

The present invention concerns a flexible stapling device (1). More particularly, this invention concerns a flexible endovascular stapling device (1) for an intravascular procedure such as patent foramen ovate closure, which is designed to avoid open heart surgery by permitting the closure of the defect utilizing a stapling means (26)... The Trustees Of Columbia University In The City Of New York

06/22/17 / #20170172804

Apparatus for perforation and aspiration of inner ear

An apparatus for controlled perforation and aspiration of the inner ear.... The Trustees Of Columbia University In The City Of New York

06/22/17 / #20170175183

Pore-forming protein conjugate compositions and methods

The present disclosure relates to compositions and methods based on a fast, efficient chemical reaction for conjugating a pore-forming protein, such as α-hemolysin, to a biomolecule, such as antibodies, receptors, and enzymes, such as DNA polymerase, and the use of such pore-forming protein conjugates in nanopore devices and methods.... The Trustees Of Columbia University In The City Of New York

06/15/17 / #20170166608

Precipitable peptides

The invention is directed to a Ca2+ precipitable polypeptide tags and cassettes useful for purification of molecules from heterogeneous samples. The invention also relates to methods for bioseparation of molecules comprising Ca2+ precipitable tags and cassettes.... The Trustees Of Columbia University In The City Of New York

06/08/17 / #20170164267

Apparatus to inhibit misuse of an electrically powered device

A system includes an electrical device comprising a power supply and circuitry and a supplemental device integrated into the electrical device. The supplemental device includes a tracker chip to receive current location data of the electrical device. The supplemental device also includes a switch with one side connected to the... The Trustees Of Columbia University In The City Of New York

06/08/17 / #20170157211

Trefoil family factor proteins and uses thereof

The invention provides for methods for treating an inflammatory disease of the digestive system in a subject by administering a trefoil family molecule. The invention provides for methods for treating a digestive system cancer in a subject by administering a trefoil family molecule. The invention provides for methods for cell... The Trustees Of Columbia University In The City Of New York

06/01/17 / #20170152486

Method for culture of human bladder cell lines and organoids and uses thereof

The invention discloses a methodology for the culture of bladder cell lines and organoids from human bladder, both non-cancerous as well as cancer tissue.... The Trustees Of Columbia University In The City Of New York

05/25/17 / #20170145055

Peptide inhibitors of caspase 2 activation

The present invention relates to compositions, including membrane permeable complexes, comprising a Caspase 2 activation inhibitory peptide having the amino acid sequence AFDAFC as well as methods of using the same for the treatment of neurodegenerative conditions associated with apoptosis in the central nervous system, such as Alzheimer's Disease, Mild... The Trustees Of Columbia University In The City Of New York

05/25/17 / #20170146479

Active cmos sensor array for electrochemical biomolecular detection

Electrochemical sensing of biomolecules eliminates the need for bulky optical instruments required in traditional fluorescence-based sensing assays. Integration of the sensor interface electrodes and active electrochemical detection circuitry on CMOS substrates miniaturizes the sensing platform, enhancing portability for point-of-care applications, while enabling high-throughput, highly-parallel analysis. One embodiment includes a four-by-four... The Trustees Of Columbia University In The City Of New York

05/25/17 / #20170148163

Systems and methods for matching and imaging tissue characteristics

Systems and methods for matching a characteristic of multiple sectors of a moving tissue to verify an overlap thereof are disclosed herein. In an exemplary method, tissue data for at least a first sector and a second sector of a moving tissue is acquired. A characteristic of at least a... The Trustees Of Columbia University In The City Of New York

05/18/17 / #20170138933

Smfret with membrane proteins

This disclosure is directed to methods of conducting dynamic single-molecule fluorescence studies such as smFRET on a membrane protein which permits observation and quantification of conformational dynamics of a membrane protein. Also disclosed herein are mutant membrane proteins in which one or more mutations have been introduced for affixing a... The Trustees Of Columbia University In The City Of New York

05/18/17 / #20170141318

Molecular compositions, materials, and methods for efficient multiple excition generation

Embodiments of the present invention provides compounds, compositions, and methods for their preparation that provide efficient intramolecular fission, such that local order and strong nearest neighbor coupling is no longer a design constraint. Inventive materials include organic oligomers and polymers designed to exhibit strong intrachain donor-acceptor interactions and provide intramolecular... The Trustees Of Columbia University In The City Of New York

05/11/17 / #20170128403

Compositions and methods for treating macular degeneration

Methods of retarding formation of a lipofuscin pigment in the retina and of treating or ameliorating the effects of a disease characterized by an accumulation of a lipofuscin pigment in a retina are provided. These methods include the step of administering to a patient in need thereof a substituted C20-retinoid... The Trustees Of Columbia University In The City Of New York

05/11/17 / #20170130218

Method of isolating aptamers for minimal residual disease detection

A method for selecting and isolating aptamers that target M-Ig proteins with a microdevice including at least a first selection chamber is provided. The method includes preparing a first sample of M-Ig proteins from a serum; placing the M-Ig proteins in the first selection chamber; introducing a first group of... The Trustees Of Columbia University In The City Of New York

05/04/17 / #20170121276

Histone acetyltransferase modulators and uses thereof

The invention provides compounds and compositions comprising compounds that modulate histone acyl transferase (HAT). The invention further provides methods for treating neurodegenerative disorders, conditions associated with accumulated amyloid-beta peptide deposits, Tau protein levels, and/or accumulations of alpha-synuclein as well as cancer by administering a compound that modulates HAT to a... The Trustees Of Columbia University In The City Of New York

04/27/17 / #20170112972

Derivation of fibrochondrocytes from progenitor cells

Provided herein are compositions and methods for forming fibrochondrocytes or fibrochondrocyte-like cells from progenitor cells, such as mesenchymal stem cells. One aspect provides a fibrochondrocyte culture medium including CTGF and TGFβ3, optionally encapsulated by microspheres having different release profiles. Another aspect provides a method for forming fibrochondrocytes or fibrochondrocyte-like cells... The Trustees Of Columbia University In The City Of New York

04/27/17 / #20170114403

Four-color dna sequencing by synthesis using cleavable fluorescent nucleotide reversible terminators

This invention provides a process for sequencing single-stranded DNA employing modified nucleotides.... The Trustees Of Columbia University In The City Of New York

04/27/17 / #20170112947

Composition for use in imaging

The present invention is for a novel composition for imaging using magnetic resonance imaging (MRI), x-rays, and x-ray computed tomography (CT). The composition shows up as an image on all type of MRIs, x-rays and CT scans, and is made of natural ingredients suitable for topical use. The composition is... The Trustees Of Columbia University In The City Of New York








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