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The Trustees Of Princeton University
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The Trustees Of Princeton University patents


Recent patent applications related to The Trustees Of Princeton University. The Trustees Of Princeton University is listed as an Agent/Assignee. Note: The Trustees Of Princeton University may have other listings under different names/spellings. We're not affiliated with The Trustees Of Princeton University, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "T" | The Trustees Of Princeton University-related inventors


 new patent  Secure optical communication channel for implantable medical devices

An implantable medical device (IMD) configured to communicate with an external device (ED). The ED supports two way RF communications and has a light source. The IMD includes a processor coupled to an optical detector, the processor is configured to verify that light is being received from the ED light... The Trustees Of Princeton University

Heterocycle analogs of cai-1 as agonists of quorum sensing in vibrio

A structurally distinct and potent series of synthetic small molecule activators of Vibrio cholerae quorum sensing have been chemically synthesized. The small molecule activators reduce virulence in V. cholerae. Acyl pyrrole molecules displayed strong potency and stability, particularly 1-(1H-pyrrol-3-yl)decan-1-one.... The Trustees Of Princeton University

Alkaline battery electrolyte useful for a rechargeable alkaline electrochemical cell

The invention provides an electrolyte composition which is adapted for use in a rechargeable alkaline electrochemical cell, and especially preferably adapted for use in a rechargeable manganese zinc electrochemical cell, which electrolyte composition imparts improved performance characteristics to the rechargeable alkaline electrochemical cell. The electrolyte composition includes an electrolyte composition... The Trustees Of Princeton University

Shmt inhibitors

The disclosure provides compounds of Formulae (I)-(IX). The disclosed compounds are capable of inhibiting a mammalian SHMT. Compounds of the disclosure have numerous uses, such as for treatment of cancer or autoimmune disorders.... The Trustees Of Princeton University

Spherical-motion average radiant temperature sensor

A mean radiant temperature sensor is used to measure radiant heat exchange to determine comfort. Disclosed herein are a spherical-motion average radiant temperature sensor (SMART Sensor) device or system, and an associated method, for taking an average overall global reading while also being able to record weighting for different directions... The Trustees Of Princeton University

Self-aligning deflector device for transmission line offset correction

Disclosed is a self-aligning mirror device for transmission line offset correction. The disclosed self-aligning mechanism automatically adjusts deflectors to couple radiation between two or more offset waveguides or optical fibers.... The Trustees Of Princeton University

Split inteins, conjugates and uses thereof

Disclosed herein are split inteins, fused proteins of split inteins, and methods of using split inteins to efficiently purify and modify proteins of interest.... The Trustees Of Princeton University

Nanowires integration for real-time compensation

A method is provided for measuring at least two flow properties of a fluid. The method includes providing at least two nanowires, the resistance of each nanowire varying based on a value of a different respective flow property such that each nanowire is configured to measure the different respective flow... The Trustees Of Princeton University

Vibration-based secure side channel for medical devices

According to some embodiments, a system for securing communications between an implantable wearable medical device (IWMD) and an external device (ED) is disclosed. The system includes a wireless radio frequency (RF) channel configured for communication between the IWMD and the ED. The system further includes a vibration-based side channel configured... The Trustees Of Princeton University

System and 3d position and gesture sensing of human hand

A three dimensional touch sensing system having a touch surface configured to detect a touch input located above the touch surface is disclosed. The system includes a plurality of capacitive touch sensing electrodes disposed on the touch surface, each electrode having a baseline capacitance and a touch capacitance based on... The Trustees Of Princeton University

System and small, clean, steady-state fusion reactors

According to some embodiments, a system for widening and densifying a scrape-off layer (SOL) in a field reversed configuration (FRC) fusion reactor is disclosed. The system includes a gas box at one end of the reactor including a gas inlet system and walls of suitable heat bearing materials. The system... The Trustees Of Princeton University

Rna containing compositions and methods of their use

The present invention relates to a composition comprising an isolated, single stranded RNA molecule having a nucleotide sequence comprising 20 or more bases and a pattern of CpG dinucleotides defined by a strength of statistical bias greater than or equal to zero, and a pharmaceutically acceptable carrier suitable for injection.... The Trustees Of Princeton University

Targeted, metal-catalyzed fluorination of complex compounds with fluoride ion via decarboxylation

Methods of preparing fluorinated compounds by carboxylative fluorination using fluoride are contained herein. Fluorinated compounds are provided. Methods of using fluorinated compounds are contained herein.... The Trustees Of Princeton University

Methods and compositions for nitrogen removal using feammox microorganisms

Processes and compositions for removal nitrogen, organic and inorganic contaminants from wastewater using Feammox bacterium are provided.... The Trustees Of Princeton University

Methods and compositions for identification of highly specific nucleases

Disclosed herein are methods and compositions for identification of specific DNA binding domains for constructing highly specific nucleases, which allows for pristine genome editing.... The Trustees Of Princeton University

Biomarkers of oocyte quality

The present technology relates to biomarkers of oocyte quality and oocyte quality dealine, as well as methods in connection with such biomarkers, including method of determining the quality of an oocyte, kits for the same, and libraries, reproductive aging gene expression profiles and profile sets with information relating the same.... The Trustees Of Princeton University

P-type transparent conducting nickel oxide alloys

Disclosed herein is the formation of p-type transparent conducting oxides (TCO) having a structure of MgxNi1-xO or ZnxNi1-xO. These structures disrupt the two-dimensional confinement of individual holes (the dominant charge carrier transport mechanism in pure NiO) creating three-dimensional hole transport by providing pathways for hole transfer in directions that are... The Trustees Of Princeton University

Optogenetic tool for rapid and reversible clustering of proteins

A protein construct including a gene encoding a light-sensitive protein fused to at least one of either a low complexity sequence, an intrinsically disordered protein region (IDR), or a repeating sequence of a linker and another gene encoding a light-sensitive protein. Among the many different possibilities contemplated, the protein construct... The Trustees Of Princeton University

Method and device for using an organic underlayer to enable crystallization of disordered organic thin films

Measurements on organic single crystals reveal remarkable optical and electrical characteristics compared to disordered films but practical device applications require uniform, pinhole-free films. Disclosed herein is a process to reliably convert as-deposited amorphous thin films to ones that are highly crystalline, with grains on the order of hundreds of microns.... The Trustees Of Princeton University

Nanochannel arrays and their preparation and use for high throughput macromolecular analysis

Nanochannel arrays that enable high-throughput macromolecular analysis are disclosed. Also disclosed are methods of preparing nanochannel arrays and nanofluidic chips. Methods of analyzing macromolecules, such as entire strands of genomic DNA, are also disclosed, as well as systems for carrying out these methods.... The Trustees Of Princeton University

System for isolating dna molecules

Systems and methods for isolating DNA molecules that can include the steps of: providing a transposon mutant collection, the transposon mutant collection being stored in a plurality of wells; dispatching aliquots from each well in the transposon mutant collection to a set of pools in a combinatorial pooling array that... The Trustees Of Princeton University

Patterning of fragile or non-planar surfaces for cell alignment

A construct that supports cell attachment and alignment including a substrate that is incompatible with photolithography conditions, containing a physical pattern in at least part of one surface, the physical pattern optionally bearing a coating of a metal alkoxide, oxide or mixed oxide-alkoxide thereon and a Self-Assembled Monolayer of Phosphonate... The Trustees Of Princeton University

Systems and methods for personalized sample analysis

Systems and methods for monitoring the health status of a subject are provided. In certain embodiments, the method includes: applying a sample provided from a subject to a signal enhancing detector configured to indicate an output that is representative of the sample; processing the output with a device configured to... The Trustees Of Princeton University

Thermal overload device containing a polymer composition containing thermally exfoliated graphite oxide and making the same

A thermal overload device containing a polymer composite, which contains at least one polymer and a modified graphite oxide material, containing thermally exfoliated graphite oxide having a surface area of from about 300 m2/g to 2600 m2/g, and a method of making the same.... The Trustees Of Princeton University

Adaptive cognitive prosthetic and applications thereof

An adaptive cognitive prosthetic that learns to replace neural function that was lost due to a brain injury or disease is described herein. In some embodiments, an adaptive cognitive prosthetic comprises a processing unit for converting input data from an input assembly into a cognitive variable and selecting a stimulation... The Trustees Of Princeton University

Efficient, manganese catalyzed process to decompose cyanide ions and hydrogen cyanide for water decontamination

Methods, kits, cartridges, and compounds related to generating chlorine dioxide by exposing ClO2− to at least one of a manganese porphyrin catalyst or a manganese porphyrazine catalyst are described. Methods, kits, cartridges, and compounds related to decomposed cyanide ions and hydrogen cyanide for water decontamination.... The Trustees Of Princeton University

Device and mechanically detecting anomalous battery operation

An anomalous battery operating detection device, which includes a sensing unit capable of measuring mechanical properties of a battery, coupled to a processor for determining whether anomalous behavior has been detected. These devices measure a mechanical property, identifying a difference in the property, and based on that difference, making a... The Trustees Of Princeton University

Frequency and back-off reconfigurability in mm-wave power amplifiers

A power amplifier system for amplifying an input having a carrier frequency having an amplitude. The system includes a plurality of n amplifiers coupled to an asymmetrical combiner formed of a passive network, each amplifier has an input and an output, the asymmetrical combiner has a plurality of inputs and... The Trustees Of Princeton University

Iron and cobalt catalyzed hydrogen isotope labeling of organic compounds

Methods of isotopic labeling are described herein. For example, a method of isotopically labeling an organic compound, in some embodiments, comprises providing a reaction mixture including the organic compound, an iron complex or a cobalt complex and a source of deuterium or tritium. The organic compound is labeled with deuterium... The Trustees Of Princeton University

Methods and devices for multi-step cell purification and concentration

Described herein are microfluidic devices and methods that can separate and concentrate particles in a sample.... The Trustees Of Princeton University

Multi-mode cavities for high-efficiency nonlinear wavelength conversion formed with overlap optimization

A dual frequency optical resonator configured for optical coupling to light having a first frequency ω1. The dual frequency optical resonator includes a plurality of alternating layer pairs stacked in a post configuration, each layer pair having a first layer formed of a first material and a second layer formed... The Trustees Of Princeton University

Modified lipopolysaccharide glycoform and use

The present disclosure generally relates to genetic engineering of bacteria. More particularly, the present disclosure describes genetic engineering of E. coli to create mutant O-antigen ligase, as well as novel lipopolysaccharide molecules resulting from that genetic engineering. Methods for using those novel molecules are also described.... The Trustees Of Princeton University

Machine-learning classifier based on comparators for direct inference on analog sensor data

A weak binary classifier configured to receive an input signal for classification and generate a classification output is disclosed. The weak binary classifier includes a plurality of weighting amplifier stages, each weighting amplifier stage being configured to receive the input signal for classification and a weighting input derived from a... The Trustees Of Princeton University

Quasicrystalline structures and uses thereof

This invention relates generally to the field of quasicrystalline structures. In preferred embodiments, the stopgap structure is more spherically symmetric than periodic structures facilitating the formation of stopgaps in nearly all directions because of higher rotational symmetries. More particularly, the invention relates to the use of quasicrystalline structures for optical,... The Trustees Of Princeton University

08/10/17 / #20170227995

Method and system for implicit authentication

A method and system capable of implicitly authenticating users based on information gathered from one or more sensors, which may be located in one or more devices, and an authentication model trained via a machine learning technique. Data is collected, manipulated, and assessed with the authentication model in order to... The Trustees Of Princeton University

08/10/17 / #20170230360

Continuous authentication system and method based on bioaura

A user authentication system for an electronic device for use with a plurality of wireless wearable medical sensors (WMSs) and a wireless base station that receives a biomedical data stream (biostream) from each WMS. The system includes a BioAura engine located on a server, the server has a wireless transmitter/receiver... The Trustees Of Princeton University

07/27/17 / #20170209386

Process for encapsulating soluble biologics, therapeutics, and imaging agents

An “inverse” precipitation route to precipitate aqueous soluble species with copolymers as nanoparticles having a hydrophilic, polar core and a less polar shell is described. A method of the invention for encapsulating water soluble molecules using rapid, controlled precipitation is presented. Water soluble molecules—including peptides, proteins, DNA, RNA, non-biologic therapeutics,... The Trustees Of Princeton University

07/27/17 / #20170209864

Methods and systems for processing particles

Described herein are improved microfluidic devices and methods for processing cells that can improve cell quality, streamline workflows, and lower costs. Applications include research and clinical diagnostics in cancer, infectious disease, and inflammatory disease, among other disease areas.... The Trustees Of Princeton University

07/27/17 / #20170213002

Safety-driven architecture for implantable and wearable medical devices

An implantable/wearable medical device is configured for use with a plurality of sensors. The device includes a host microcontroller, a safety coprocessor and an actuator. The host microcontroller is configured to receive physiological data from the sensors and generate actuator commands for the actuator. The host microcontroller is configured to... The Trustees Of Princeton University

07/13/17 / #20170201394

System and disintegrated channel estimation in wireless networks

A system and method for disintegrated channel estimation in wireless networks. The system provides a disintegrated channel estimation technique required to accomplish the spatial diversity supported by cooperative relays. The system includes a filter-and-forward (FF) relaying method with superimposed training sequences for separately estimating the backhaul and the access channels.... The Trustees Of Princeton University

07/06/17 / #20170189481

Use of peptides that block metadherin- snd1 interaction as treatment for cancer

The present disclosure related in general to methods of treating cancer by interfering with the interaction of metadherin with Staphylococcal nuclease domain-containing 1 (SND1) using peptides or other compounds that inhibit the binding of SND1 with metadherin and inhibit the activity of the MTDH-SND1 complex in tumor cells.... The Trustees Of Princeton University

07/06/17 / #20170195158

System and performing initial synchronization during wireless sector searches

A system and method for performing initial synchronization during wireless sector searches. The system includes a first subsystem for coarse timing alignment including a decimator to reduce computational complexity and a long-lag differential correlator, a second subsystem for jointly estimating RTE and FFO utilizing a short-lag differential correlator, and a... The Trustees Of Princeton University

06/29/17 / #20170186561

Graphene-ionic liquid composites

Method of making a graphene-ionic liquid composite. The composite can be used to make electrodes for energy storage devices, such as batteries and supercapacitors.... The Trustees Of Princeton University

06/01/17 / #20170152207

Compositions and methods for hydrocarbon functionalization

Embodiments of the present disclosure provide for methods of hydrocarbon functionalization, methods and systems for converting a hydrocarbon into a compound including at least one group ((e.g., hydroxyl group) (e.g., methane to methanol)), functionalized hydrocarbons, and the like.... The Trustees Of Princeton University

05/18/17 / #20170135802

3d printed patient-specific conduits for treating complex peripheral nerve injury

The present invention includes biomimetic nerve conduits that can be used as nerve regeneration pathways. The present invention further provides methods of preparing and using biomimetic nerve conduits. The disclosed compositions and methods have a broad range of potential applications, for example replacing a missing or damaged section of a... The Trustees Of Princeton University

05/18/17 / #20170137549

Transition metal catalysts for olefin polymerization

In one aspect, a chelating phosphine-phosphonic diamide (PPDA) ligand is described herein for constructing transition metal complexes operable for catalysis of olefin polymerization, including copolymenzation of ethylene with polar monomer.... The Trustees Of Princeton University

05/18/17 / #20170138799

Fast response temperature sensor

In the present invention, a temperature sensor system and methods for using the apparatus are disclosed, the temperature sensor having particular thermal-inertia time constants. More specifically, the temperature sensor system comprises prongs having a defined l/d ratio range, a sensing element having a low volume, and constant-current circuitry.... The Trustees Of Princeton University

05/04/17 / #20170123528

System and 3d position and gesture sensing of human hand

A three dimensional touch sensing system having a touch surface configured to detect a touch input located above the touch surface is disclosed. The system includes a plurality of capacitive touch sensing electrodes disposed on the touch surface, each electrode having a baseline capacitance and a touch capacitance based on... The Trustees Of Princeton University

04/06/17 / #20170098454

Method and system for producing low-noise acoustical impulse responses at high sampling rate

The method and system for measuring low-noise acoustical impulse responses at high sampling rates of the present invention utilizes two exponential sine sweeps (ESSs) to measure the impulse responses. The first ESS is a quick sweep up to the Nyquist frequency to provide an estimate of the system response and... The Trustees Of Princeton University

03/23/17 / #20170082780

Non-crystaline materials having complete photonic, electronic or phononic band gaps

The invention provides an article of manufacture, and methods of designing and making the article. The article permits or prohibits waves of energy, especially photonic/electromagnetic energy, to propagate through it, depending on the energy band gaps built into it. The structure of the article may be reduced to a pattern... The Trustees Of Princeton University

03/16/17 / #20170073504

Functionalized graphene sheets having high carbon to oxygen ratios

Functionalized graphene sheets having a carbon to oxygen molar ratio of at least about 23:1 and method of preparing the same.... The Trustees Of Princeton University

03/09/17 / #20170067102

Nanochannel arrays and their preparation and use for high throughput macromolecular analysis

Nanochannel arrays that enable high-throughput macromolecular analysis are disclosed. Also disclosed are methods of preparing nanochannel arrays and nanofluidic chips. Methods of analyzing macromolecules, such as entire strands of genomic DNA, are also disclosed, as well as systems for carrying out these methods.... The Trustees Of Princeton University

03/02/17 / #20170056331

Novel droplet-embedded microfibers, and methods and devices for preparing and using same

The invention includes microfluidic methods and devices that allow for the continuous production of microfibers with embedded droplets aligned along the length of the fiber at specific positions. The invention allows for formation of single or multiple emulsions within a fiber. The various phases comprised within the fiber can vary... The Trustees Of Princeton University

03/02/17 / #20170062641

Multiple band gap co-ni oxide compositions and applications thereof

In one aspect, metal oxide compositions having electronic structure of multiple band gaps are described. In some embodiments, a metal oxide composition comprises a (Co,Ni)O alloy having electronic structure including multiple band gaps. The (Co,Ni)O alloy can include a first band gap and a second band gap, the first band... The Trustees Of Princeton University

03/02/17 / #20170063461

Multibeam radio frequency photonic beamformer using a multi-signal slow light time delay unit

A photonic beamformer is disclosed and is configured to transmit or receive a plurality of RF input signals from a plurality of antennas. The beamformer receiver includes a plurality of optical modulators, each optical modulator being configured to modulate each of the RF input signals onto an optical carrier, each... The Trustees Of Princeton University

02/16/17 / #20170042818

Lung targeting dual drug delivery system

The American Cancer Society estimated that in 2009, 1,479,350 new cancer cases would be diagnosed in the United States of which 219,440 would be lung and bronchus related. The standard treatments for NSCLC include surgery, chemotherapy, radiation, laser and photodynamic therapy, all with various success rates depending on the stage... The Trustees Of Princeton University

02/16/17 / #20170042823

Co-encapsulation of antimicrobials and adjuvants in nanocarriers

Microbial infections have become increasingly difficult to treat due to the emergence of drug resistant microbes. Adjunctive therapies can be used to better treat resistant microbes, where multiple drugs are concurrently used to overcome resistant mechanisms and to synergistically treat infections. The practice of adjunctive therapies is limited by the... The Trustees Of Princeton University

02/16/17 / #20170044570

Engineered cellular pathways for programmed autoregulation of differentiation

The present invention provides compositions and methods for programming mammalian cells to perform desired functions. In particular, the present invention provides compositions and methods for programming stem cells to differentiate into a desired cell type. A quorum sensing systems that regulates the expression of cell fate regulators is introduced into... The Trustees Of Princeton University

02/16/17 / #20170048395

System and methods for time deferred transmission of mobile data

A system for time deferred usage of mobile data by a plurality of user devices each coupled to a network server and running one or more applications. The system includes a network measurement module, user profiling module and a price-optimization computational module located at the network server and a user... The Trustees Of Princeton University

02/09/17 / #20170037234

Polymer nanoparticles

Polymer nanoparticles, including Janus nanoparticles, and methods of making them are described.... The Trustees Of Princeton University

02/02/17 / #20170034912

Printed electronics

Printed electronic device comprising a substrate onto at least one surface of which has been applied a layer of an electrically conductive ink comprising functionalized graphene sheets and at least one binder. A method of preparing printed electronic devices is further disclosed.... The Trustees Of Princeton University

01/26/17 / #20170022185

Decarboxylative cross-coupling and applications thereof

Methods described herein enable the production of numerous molecular species through decarboxylative cross-coupling via use of photoredox and transition metal catalysts. For example, methods described herein enable the production of numerous molecular species through decarboxylative cross-coupling via use of photoredox and transition metal catalysts. A method described herein, in some... The Trustees Of Princeton University

01/26/17 / #20170022532

Method for awakening silent gene clusters in bacteria and discovery of cryptic metabolites

The majority of clinically used antibiotics and anticancer agents are derived from bacterial small molecules. These molecules are produced by dedicated biosynthetic gene clusters, sets of genes that are responsible for the step-wise generation of the target small molecule. Recent investigations have indicated, to the surprise of many experts, that... The Trustees Of Princeton University

01/26/17 / #20170025677

Hyper-dendritic nanoporous zinc foam anodes, methods of producing the same, and methods for their use

Disclosed are hyper-dendritic nanoporous zinc foam electrodes, viz., anodes, methods of producing the same, and methods for their use in electrochemical cells, especially in rechargeable electrical batteries.... The Trustees Of Princeton University

Patent Packs
01/19/17 / #20170014504

Cytomegalovirus vaccines and methods of production

Methods of increasing diversity in cytomegalovirus vaccines through the selection of cell type in which the virus is propagated, and the use of cytomegalovirus produced by those methods in the development of vaccine compositions, are disclosed. Vaccine compositions comprising CMV isolated from epithelial cells are also disclosed.... The Trustees Of Princeton University

01/19/17 / #20170015921

Process for generating cool frame and flameless fuel oxidation using non-equilibrium plasma activation

An exemplary embodiment can be an exemplary method, which can include, for example, generating a cool flame(s) using a plasma-assisted combustion, and maintaining the cool flame(s). The cool flame(s) can have a temperature below about 1050 Kelvin, which can be about 700 Kelvin. The cool flame(s) can be further generated... The Trustees Of Princeton University

01/19/17 / #20170018732

Hybrid layers for use in coatings on electronic devices or other articles

A method for protecting an electronic device comprising an organic device body. The method involves the use of a hybrid layer deposited by chemical vapor deposition. The hybrid layer comprises a mixture of a polymeric material and a non-polymeric material, wherein the weight ratio of polymeric to non-polymeric material is... The Trustees Of Princeton University

01/19/17 / #20170019121

Multiplying analog to digital converter and method

A multiplying analog to digital converter including an analog to digital converter (ADC) having a sample input and a feedback input and an ADC output configured with a feedback path configured to couple the ADC output to a digital to analog converter. A feedback attenuator is disposed in the feedback... The Trustees Of Princeton University

01/05/17 / #20170000769

Nadph production by the 10-formyl-thf pathway, and its use in the diagnosis and treatment of disease

A 10-formyl-THF pathway for producing NADPH is useful in the diagnosis and treatment of cancer and metabolic disease, in the development of new antineoplastic agents and/or regimens, in the development of new methods for measuring metabolic pathway activity, and in the development of new therapeutics for treating metabolic disease.... The Trustees Of Princeton University

06/01/17 / #20170153339

Passive waveguide structures and integrated detection and/or imaging systems incorporating the same

Passive components adapted for integration with at least one active semiconductor device, in an embodiment, comprise at least one metallic structure dimensioned and arranged to absorb and/or reflect a major fraction of incident electromagnetic radiation received at one or more wavelengths of a first group of wavelengths. This prevents radiation... The Trustees Of Princeton University

02/16/17 / #20170047199

Scanning probe lithography methods

Provided among other things are a scanning electron microscope, scanning transmission electron microscope, focused ion beam microscope, ion beam micromachining device, or scanning probe nanofabrication device, wherein the microscope or device is configured to move a substrate and a scanning modality relative to one another with an enclosed sinusoidal trajectory,... The Trustees Of Princeton University








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