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The Trustees Of The University Of Pennsylvania
The Trustees Of The University Of Pennsylvania And Imclone Llc
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The Trustees Of The University Of Pennsylvania_20100121
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The Trustees Of The University Of Pennsylvania patents


Recent patent applications related to The Trustees Of The University Of Pennsylvania. The Trustees Of The University Of Pennsylvania is listed as an Agent/Assignee. Note: The Trustees Of The University Of Pennsylvania may have other listings under different names/spellings. We're not affiliated with The Trustees Of The University Of Pennsylvania, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "T" | The Trustees Of The University Of Pennsylvania-related inventors


Radiotracer derivatives of trimethoprim for diagnositc imaging

The present invention provides radiolabeled trimethoprim which are useful in imaging tests such as PET scans. The compounds show robust bacterial uptake in vitro and identify infections from inflammation or tumor when administered to a subject. The compounds show rapid and sensitive detection of Ec DHFR containing tumors from control... The Trustees Of The University Of Pennsylvania

Compositions to disrupt protein kinase a anchoring and uses thereof

The invention provides compositions and methods for treating diseases associated with expression of a cancer associated antigen as described herein. The invention also relates to chimeric antigen receptor (CAR) specific to a cancer associated antigen and modified T-cell receptor (TCR) T cells as described herein, vectors encoding the same, and... The Trustees Of The University Of Pennsylvania

System and virtual radiation therapy quality assurance

A method comprises receiving one or more plan parameters of a first radiation treatment plan for a first patient and one or more passing rate data for the first treatment plan; generating a predictive model for passing rate data from the plan parameters of the first radiation treatment plan and... The Trustees Of The University Of Pennsylvania

Vaccines with cd40 ligand as an adjuvant

Disclosed herein is a vaccine comprising an antigen and CD40L. Also disclosed herein are methods for increasing an immune response in a subject. The methods may comprise administering the vaccine to the subject in need thereof.... The Trustees Of The University Of Pennsylvania

Multi-sensor fusion for robust autonomous flight in indoor and outdoor environments with a rotorcraft micro-aerial vehicle (mav)

The subject matter described herein includes a modular and extensible approach to integrate noisy measurements from multiple heterogeneous sensors that yield either absolute or relative observations at different and varying time intervals, and to provide smooth and globally consistent estimates of position in real time for autonomous flight. We describe... The Trustees Of The University Of Pennsylvania

Synthetic immunogens for prophylaxis or treatment of tuberculosis

Compositions comprising a nucleic acid molecule that encodes TB esat-6 proteins are disclosed. Methods of inducing an immune response against TB an individual are disclosed. Method of treating an individual who has been diagnosed with TB are disclosed. Method of preventing TB infection in an individual are disclosed.... The Trustees Of The University Of Pennsylvania

Isg15 and its use as an adjuvant

Disclosed herein is a vaccine comprising an antigen and ISG15. Also disclosed herein is a method for increasing an immune response in a subject in need thereof. Further disclosed herein is a method for treating a subject in need thereof. The methods may comprise administering the vaccine to the subject.... The Trustees Of The University Of Pennsylvania

Antibacterial coatings that inhibit biofilm formation on implants

Orthopedic and dental implants coated with an antibacterial coating and methods of making and using, are described herein. The implant can be coated with a hydrophobic, polycationic antibacterial polymer. The polymer can be covalently or non-covalently associated with the surface; however, in particular embodiments, the polymer is non-covalently associated with... The Trustees Of The University Of Pennsylvania

Aza-amino acid collagen compounds

The invention relates to aza-amino acid backbone-modified biomimetic collagens and general methods for designing and making biomimetic materials and molecular mimics.... The Trustees Of The University Of Pennsylvania

Fusion proteins for modulating regulatory and effector t cells

The present invention provides fusion proteins that act on the glucocorticoid-induced TNFR family-related gene (GITR) and OX40 signaling pathway. The proteins of the invention are useful in modulating both regulatory T (Treg) cells and effector T (Teff) cells.... The Trustees Of The University Of Pennsylvania

Compositions and methods for treating asthma and other lung diseases

The present invention provides methods for dilating the bronchi or bronchioles and relaxing a pulmonary smooth muscle in a subject by treating the subject with a pharmaceutical composition, which includes a Histone deacetylase (HDAC) inhibitor. The ability to dilate the bronchi or bronchioles and relax a pulmonary smooth muscle according... The Trustees Of The University Of Pennsylvania

Novel chronotherapy based on circadian rhythms

The invention includes a formulation of a therapeutic compound, wherein release of the therapeutic compound from the formulation coincides with peak or trough expression of at least one target gene of the therapeutic compound. The invention also includes a method of developing such formulations and a method of treating a... The Trustees Of The University Of Pennsylvania

Compositions and methods for suppressing or reducing systemic immune response in a subject

The present invention includes a method of suppressing systemic immune response in a subject, the method comprising topically administering a pharmaceutically effective amount of a vitamin D analog to a subject in need thereof. The present invention further includes a method of treating an autoimmune disease in a subject, the... The Trustees Of The University Of Pennsylvania

Methods and compositions of a follicle stimulating hormone receptor immunoreceptor or chimeric antigen receptor

The present invention relates to compositions and methods for diagnosing and treating diseases, disorders or conditions associated with dysregulated expression of FSHR. The invention provides novel peptides that specifically bind to Follicle-stimulation hormone receptor (FSHR).... The Trustees Of The University Of Pennsylvania

Combination of ifn-gamma with anti-erbb antibody for the treatment of cancers

ii) a fusion protein of the invention.... The Trustees Of The University Of Pennsylvania

Enhancing activity of car t cells by co-introducing a bispecific antibody

The present invention provides compositions and methods for treating cancer in a human. The invention includes administering a T cell, genetically modified to express a chimeric antigen receptor (CAR), a bispecific antibody, or a combination thereof to a subject. The CAR and bispecific antibody of the invention can comprise a... The Trustees Of The University Of Pennsylvania

Method of increasing the function of an aav vector

A method of correcting singletons in a selected AAV sequence in order to increasing the packaging yield, transduction efficiency, and/or gene transfer efficiency of the selected AAV is provided. This method involves altering one or more singletons in the parental AAV capsid to conform the singleton to the amino acid... The Trustees Of The University Of Pennsylvania

Polymerized ionic liquid block copolymers as battery membranes

The present invention is directed to lithium ion transport media for use in separators in lithium ion batteries, and the membranes, separators, and devices derived therefrom.... The Trustees Of The University Of Pennsylvania

Methods and compositions for treating hypoglycemic disorders

This invention relates to methods of treating and ameliorating congenital and neonatal hyperinsulinism and post-prandial hypoglycemia, comprising the step of administering an antagonist of the Glucagon-Like Peptide-1 (GLP-1) receptor, e.g. a GLP-1 fragment or analogue thereof.... The Trustees Of The University Of Pennsylvania

System, method, and device for high-throughput, automated culturing of genetically modified organisms

A fluid transfer system includes a transfer carousel capable of rotational and/or translational movement; at least one holding vessel (e.g. syringe) having a plunger, wherein the syringe is connected to the transfer carousel such that the movement of the transfer carousel results in movement of the syringe and wherein the... The Trustees Of The University Of Pennsylvania

Treatment of cancer using a cd33 chimeric antigen receptor

The invention provides compositions and methods for treating diseases associated with expression of CD33. The invention also relates to chimeric antigen receptor (CAR) specific to CD33, vectors encoding the same, and recombinant T cells comprising the CD33 CAR. The invention also includes methods of administering a genetically modified T cell... The Trustees Of The University Of Pennsylvania

Car-expressing cells against multiple tumor antigens and uses thereof

The invention provides compositions and methods for treating cancer by using immune effector cells (e.g., T cells, NK cells) engineered to conditionally express an agent which enhances the immune effector response of an immune effector cell that expresses a Chimeric Antigen Receptor (CAR). The conditional agents described herein include agents... The Trustees Of The University Of Pennsylvania

Artificial placenta and methods of preparation

The presently disclosed subject matter provides a microfluidic device that can simulate capillary blood flow on a fetal side of the device and pooled blood on a maternal side of the device (i.e., intervillous space). The microfluidic device can reconstitute the maternal-fetal interface, can expand the capabilities of cell culture... The Trustees Of The University Of Pennsylvania

Aav-mediated gene therapy for rpgr x-linked retinal degeneration

Described herein are methods of preventing, arresting progression of or ameliorating vision loss and other conditions associated with retinitis pigmentosa and x-linked retinitis pigmentosa in a subject. The methods include administering to said subject an effective concentration of a composition comprising a recombinant adeno-associated virus (AAV) carrying a nucleic acid... The Trustees Of The University Of Pennsylvania

Use of the cd2 signaling domain in second-generation chimeric antigen receptors

The present invention provides compositions and methods for treating cancer in a human. The invention includes relates to administering a genetically modified T cell expressing a CAR having an antigen binding domain, a transmembrane domain, a CD2 signaling domain, and a CD3 zeta signaling domain. The invention also includes incorporating... The Trustees Of The University Of Pennsylvania

User interface input handheld and mobile devices

Methods, systems, and computer readable media for receiving user input. According to one example method for receiving user input, the method includes identifying gestures from directional movements of a user's fingers on a touch sensor, mapping the gestures to alphanumeric characters, and outputting alphanumeric characters, including defining a set of... The Trustees Of The University Of Pennsylvania

Iron oxide nanoparticles and methods of use thereof

The presently disclosed subject matter relates to iron oxide nanoparticle compositions and formulations thereof for: (1) the treatment and elimination of biofilms; (2) the prevention of biofilm formation; (3) biofilm extracellular matrix degradation; (4) the inhibition of bacterial viability and growth within the biofilm; and (5) the prevention of tooth... The Trustees Of The University Of Pennsylvania

Administration of plant expressed oral tolerance agents

Protein replacement therapy for patients with hemophilia or other inherited protein deficiencies is other complicated by pathogenic antibody responses, including antibodies that neutralize the therapeutic protein or that predispose to potentially life-threatening anaphylactic reactions by formation of IgE. Using murine hemophilia B as a model, we have developed a prophylactic... The Trustees Of The University Of Pennsylvania

Proteins comprising mrsa pbp2a and fragments thereof, nucleic acids encoding the same, and compositions and their use to prevent and treat mrsa infections

Nucleic acid molecules which encode an MRSA PBP2a protein or a fragment thereof which comprises at least 245 amino acid are disclosed. Compositions comprising the nucleic acid molecules are disclosed. Novel proteins which comprise a MRSA PBP2a protein or a fragment thereof which comprises at least 245 amino acid are... The Trustees Of The University Of Pennsylvania

Protease triggered release of molecules from hydrogels

The invention relates to compositions comprising (i) biocompatible hydrogel and (ii) one or more therapeutic agents contained within said hydrogel; wherein the hydrogel is cross-linked utilizing a cross-linker comprising a peptide sequence that is capable of being degraded by an enzyme; the therapeutic agent being effective as a treatment of... The Trustees Of The University Of Pennsylvania

Fully-human t-cell receptor specific for the 369-377 epitope derived from the her2/neu (erbb2) receptor protein.

The present invention relates to compositions and methods for treating HER2/Neu (ERBB2) expressing cancer cells. In some embodiments, the invention includes an isolated T cell receptor (TCR) having high affinity for and that specifically binds ERBB2369-377 epitope on a target cell. Other embodiments include a T cell or a population... The Trustees Of The University Of Pennsylvania

Method of detecting and/or identifying adeno-associated virus (aav) sequences and isolating novel sequences identified thereby

Adeno-associated virus rh.10 sequences, vectors containing same, and methods of use are provided.... The Trustees Of The University Of Pennsylvania

Regulation of autophagy and cell survival

Methods of treating an individual who has been identified as having glycolysis dependent cancer are disclosed. The methods comprise the step of: administering to suc an individual a combination of an anti-cancer composition that renders the cancer incapable of glycolysis and an autophagy inhibitor. Pharmaceutical compositions and kits comprising that... The Trustees Of The University Of Pennsylvania

Method and improving cognitive performance

A method for delivering electrical stimulation to alter a cognitive state of a user, the method comprising: monitoring a brain signal from the user via one or more intracranial electrodes implanted in the brain of the user while the user is presented with a stimulus; comparing the brain signal to... The Trustees Of The University Of Pennsylvania

Targeting cytotoxic cells with chimeric receptors for adoptive immunotherapy

The present invention provides compositions and methods for regulating the specificity and activity of T cells. In one embodiment, the invention provides a type of chimeric antigen receptor (CAR) wherein the CAR is termed a “KIR-CAR” which is a CAR design comprising a component of a receptor naturally found on... The Trustees Of The University Of Pennsylvania

01/25/18 / #20180024140

Atomic description of immune complex that causes heparin-induced thrombocytopenia

The present invention provides a humanized antibody or antibody fragment comprising (a) a humanized light chain comprising 1) Complementarity Determining Region (CDR)-L1, the sequence of which is identical to the sequence of SEQ ID NO: 3; 2) CDR-L2, the sequence of which is identical to the sequence of SEQ ID... The Trustees Of The University Of Pennsylvania

01/18/18 / #20180015149

Collagen iii composition and uses

The invention includes methods of suppressing cancer metastasis and local recurrence in a subject. In one aspect, the method comprises removing the tumor by surgery; and implanting a composition of the invention to the site of the primary tumor. In another aspect, the method comprises implanting a composition of the... The Trustees Of The University Of Pennsylvania

01/18/18 / #20180015161

Checkpoint inhibitor and vaccine combinations and use of same for immunotherapy

Disclosed herein is a vaccine comprising an antigen and checkpoint inhibitor. Also disclosed herein is a method for enhancing an immune response in a subject. The method may comprise administering the vaccine to the subject in need thereof.... The Trustees Of The University Of Pennsylvania

01/18/18 / #20180016598

Simian adenoviruses sadv-43, -45, -46, -47, -48, -49, and -50, and uses thereof

A recombinant vector comprises simian adenovirus 43, 45, 46, 47, 48, 49 or 50 sequences and a heterologous gene under the control of regulatory sequences. A cell line which expresses simian adenovirus 43, 45, 46, 47, 48, 49 or 50 gene(s) is also disclosed. Methods of using the vectors and... The Trustees Of The University Of Pennsylvania

01/18/18 / #20180016638

Novel methods for early identification of bone healing ability in injured patients

The present invention relates to the discovery that the expression levels of some RNA molecules, comprising messenger RNA (mRNA), non-coding RNA (ncRNA) and/or microRNA (miRNA), and protein can be used as a diagnostic signature to predict or monitor the bone healing ability in an acutely injured subject or in a... The Trustees Of The University Of Pennsylvania

01/04/18 / #20180000928

Immunogenicity of an optimized synthetic consensus dna vaccine for porcine epidemic diarrhea virus

Provided herein is a vaccine comprising a Porcine Epidemic Diarrhea Virus (PEDV) antigen. The antigen can be a consensus antigen. Also disclosed herein is a method of treating a porcine in need thereof, by administering the vaccine to the porcine.... The Trustees Of The University Of Pennsylvania

01/04/18 / #20180002698

C-rel-specific sirna and its use for preventing and treating autoimmune psoriasis

The present invention provides a c-Rel-specific siRNA and its use for preventing and treating autoimmune psoriasis. In particular, the c-Rel-specific siRNAs have sequences as shown in SEQ ID Nos. 1-2 or SEQ ID Nos. 3-4. In the present invention, small interfering RNA (siRel) specific to c-Rel are employed to inhibit... The Trustees Of The University Of Pennsylvania

01/04/18 / #20180002716

Compositions and methods thereof for down-regulation of genes following oral delivery of an rnai molecule bioencapsulated within plant cells

Compositions and methods for down-regulating genes through oral administration of RNAi molecule encapsulated in plant cells are provided.... The Trustees Of The University Of Pennsylvania

12/28/17 / #20170368180

Methods of promoting nervous system regeneration

The invention includes a composition comprising an astrocyte comprising aligned and elongated astrocyte processes resulting from ex vivo machine-driven, physical stretching of the astrocyte maintained in culture, as well as a method of making it. The invention also includes a composition comprising an astrocyte comprising aligned bi-polar processes resulting from... The Trustees Of The University Of Pennsylvania

12/28/17 / #20170369561

Glypican-3-specific antibody and uses thereof

The present invention relates to compositions and methods for diagnosing and treating diseases, disorders or conditions associated with dysregulated expression of GPC3. The invention provides novel antibodies that specifically bind to glypican-3 (GPC3). The invention also relates to a fully human chimeric antigen receptor (CAR) wherein the CAR is able... The Trustees Of The University Of Pennsylvania

12/28/17 / #20170369777

Morphologically and size uniform monodisperse particles and their shape-directed self-assembly

Monodisperse particles having: a single pure crystalline phase of a rare earth-containing lattice, a uniform three-dimensional size, and a uniform polyhedral morphology are disclosed. Due to their uniform size and shape, the monodisperse particles self assemble into superlattices. The particles may be luminescent particles such as down-converting phosphor particles and... The Trustees Of The University Of Pennsylvania

12/28/17 / #20170372137

Systems, devices, and methods for robotic remote sensing for precision agriculture

The present subject matter relates to systems, devices, and methods for data-driven precision agriculture through close-range remote sensing with a versatile imaging system. This imaging system can be deployed onboard low-flying unmanned aerial vehicles (UAVs) and/or carried by human scouts. Additionally, the present technology stack can include methods for extracting... The Trustees Of The University Of Pennsylvania

12/21/17 / #20170362295

Use of icos-based cars to enhance antitumor activity and car persistence

The present invention provides compositions and methods for treating cancer in a human. The invention includes administering a genetically modified Th17 cell to express a CAR having an antigen binding domain, a transmembrane domain, and an ICOS intracellular signaling domain.... The Trustees Of The University Of Pennsylvania

12/21/17 / #20170362669

Compositions, kits, and methods to detect hiv virus

Provided herein include compositions comprising a primer having the nucleic acid sequence of ACeIN-F3_c, a primer having the nucleic acid sequence of ACeIN-B3_a, a primer having the nucleic acid sequence of ACeIN-B3_b, a primer having the nucleic acid sequence of ACeIN-FIP_e, a primer having the nucleic acid sequence of ACeIN-FIP_f,... The Trustees Of The University Of Pennsylvania

12/21/17 / #20170365057

Semi-automated heart valve morphometry and computational stress analysis from 3d images

A method is provided for measuring or estimating stress distributions on heart valve leaflets by obtaining three-dimensional images of the heart valve leaflets, segmenting the heart valve leaflets in the three-dimensional images by capturing locally varying thicknesses of the heart valve leaflets in three-dimensional image data to generate an image-derived... The Trustees Of The University Of Pennsylvania

12/14/17 / #20170354324

Vision test for determining retinal disease progression

The present invention provides a reading test to measure vision loss. In one embodiment, the vision loss is due to disease progression. The tests are useful in evaluating the effects of intervention in vision deterioration. The tests are non-invasive, simple, quick, sensitive, reproducible, and easy to administer. The tests measure... The Trustees Of The University Of Pennsylvania

12/14/17 / #20170354369

Methods and systems for testing opticokinetic nystagmus

A mobile system for measuring opticokinetic nystagmus in a subject includes a display screen to provide an opticokinetic stimulus and an imaging system to record eye movement data of the subject. The mobile system is configured to compare the stimulus and the recorded eye movement data to provide objective vision... The Trustees Of The University Of Pennsylvania

12/14/17 / #20170355778

Compositions and methods of treating tumors

Methods of treating an individual who has an erbB protein mediated tumor is disclosed. Methods of preventing erbB protein mediated tumors in an individual are disclosed. The methods comprise administering to the individual a nucleic acid molecule that encodes a protein that dimerizes with an erbB protein and that is... The Trustees Of The University Of Pennsylvania

12/07/17 / #20170348387

Aav-mediated gene therapy for nphp5 lca-ciliopathy

Described herein are methods of preventing, arresting progression of or ameliorating vision loss and other conditions associated with Leber congenital amaurosis (LCA) in a subject. The methods include administering to said subject an effective concentration of a composition comprising a recombinant adeno-associated virus (AAV) carrying a nucleic acid sequence encoding... The Trustees Of The University Of Pennsylvania

11/30/17 / #20170342124

Universal immune receptor expressed by t cells for the targeting of diverse and multiple antigens

The invention provides compositions and methods for adoptive T cell therapy in treating a variety of disorders including cancer, infections, and autoimmune disorders. In one embodiment, the invention provides a universal immune receptor (UnivIR) that comprises an extracellular label binding domain, a transmembrane domain, and a cytoplasmic domain or otherwise... The Trustees Of The University Of Pennsylvania

11/30/17 / #20170342436

Transgenic plants exhibiting enhanced phytochelatin-based heavy metal tolerance and methods of use thereof

Transgenic plants exhibiting phytochelatin-based heavy metal tolerance and methods of use thereof for bioremediation are disclosed.... The Trustees Of The University Of Pennsylvania

11/30/17 / #20170343533

Fluid separator for point of care molecular diagnostics

The present disclosure provides devices and methods using Plasma coil r separating a fluid—e.g., plasma or serum—from whole blood. In some embodiments, the devices and methods use hydrophobic or superhydrophobic surfaces to encourage whole blood to contact a selective membrane that extracts the desired fluid component from the blood.... The Trustees Of The University Of Pennsylvania

11/30/17 / #20170343565

Biomarkers for seizures

The application relates to markers for seizures and epilepsy. Polypeptide expression panels or arrays are provided, comprising one or more probes capable of binding specific polypeptides in blood plasma or blood serum of a mammalian subject. Also provided are methods for detecting seizure, methods for predicting seizure, use of sICAM-5... The Trustees Of The University Of Pennsylvania

11/23/17 / #20170332981

A for magnetic resonance imaging data acquisition guided by physiologic feedback

An adaptive real-time radial k-space sampling trajectory (ARKS) can respond to a physiologic feedback signal to reduce motion effects and ensure sampling uniformity. In this adaptive k-space sampling strategy, the most recent signals from an ECG waveform can be continuously matched to the previous signal history, new radial k-space locations... The Trustees Of The University Of Pennsylvania

11/23/17 / #20170333450

Compositions and methods for treating hiv-associated cognitive dysfunction

The present invention provides methods comprising treating and/or preventing cognitive dysfunction in subjects infected with HIV by administering an antioxidant inflammation modulator (AIM). The present invention also provides for methods for treating and/or preventing an HIV-associated neurocognitive disorder by contacting peripheral blood monocytes of an HIV+subject with an AIM.... The Trustees Of The University Of Pennsylvania

11/23/17 / #20170334890

Small molecule activators of mitochondrial function

are described that are beneficial in treating, for example, diseases and conditions such as Friedreich's ataxia, normal aging, and various neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. Furthermore, such compounds are useful as probes for identifying defects in mitochondrial metabolism, mitochondrial iron accumulation, cellular stress among other mitochondrial... The Trustees Of The University Of Pennsylvania

11/23/17 / #20170334967

Treatment of cancer using gfr alpha-4 chimeric antigen receptor

The present invention relates to compositions and methods for treating diseases, disorders or conditions associated with the expression of the Glycosyl-phosphatidylinositol (GPI)-linked GDNF family α-receptor 4 (GFRα4).... The Trustees Of The University Of Pennsylvania

11/23/17 / #20170334980

Anti-properdin antibodies and uses thereof

This invention relates to selective inhibition of the alternative pathway (AP) of the complement system using an anti-properdin antibody. Specifically, the invention relates to methods of treating an AP-mediated pathology or AP-mediated condition in an individual by contacting the individual with an anti-properdin antibody.... The Trustees Of The University Of Pennsylvania

11/23/17 / #20170335281

Treatment of cancer using chimeric antigen receptor

The invention provides compositions and methods for treating diseases associated with expression of a cancer associated antigen as described herein. The invention also relates to chimeric antigen receptor (CAR) specific to a cancer associated antigen as described herein, vectors encoding the same, and recombinant T cells comprising the CARs of... The Trustees Of The University Of Pennsylvania

11/23/17 / #20170335331

Altering gene expression in cart cells and uses thereof

The present invention relates to compositions and methods for generating a modified T cell with a nucleic acid capable of downregulating endogenous gene expression selected from the group consisting of TCR α chain, TCR β chain, beta-2 microglobulin, a HLA molecule, CTLA-4, PD1, and FAS and further comprising a nucleic... The Trustees Of The University Of Pennsylvania

Patent Packs
11/23/17 / #20170335395

A parkinson's disease diagnostic biomarker panel

The present invention relates to a method of diagnosing Parkinson's disease in a subject using a novel set of biomarkers. The invention further includes compositions, methods and uses of a novel set of biomarkers to assess the risk of developing Parkinson's disease, to provide pre-symptomatic diagnosis of Parkinson's disease, and... The Trustees Of The University Of Pennsylvania

11/16/17 / #20170326253

Ph-sensitive peptides and their nanoparticles for drug delivery

A new nanoscale carrier made by one or more pH-sensitive peptides is provided for delivery of a biologically active substance. The peptides are composed of pH-sensitive hydrophilic and hydrophobic amino acids in the backbone. As the pH environment changes from physiological pH level to a weakly acidic environment such as... The Trustees Of The University Of Pennsylvania

11/16/17 / #20170327842

Purification and purity assessment of rna molecules synthesized with modified nucleosides

This invention provides purified preparations of an RNA, oligoribonucleotide, or polyribonucleotide comprising a modified nucleoside, and methods of assessing purity of purified preparations of an RNA, oligoribonucleotide, or polyribonucleotide comprising a modified nucleoside.... The Trustees Of The University Of Pennsylvania

11/09/17 / #20170319058

Apparatus and methods for testing visual function and functional vision at varying luminance levels

A test of visual function and/or functional vision may be performed at varying luminance levels. A first course may be selected for a subject. A given course may comprise a layout having a beginning point, at least one turn, at least one obstacle, and an ending point. The first course... The Trustees Of The University Of Pennsylvania

11/09/17 / #20170319319

Systems and methods for mesh augmentation and prevention of incisional hernia

Techniques for mesh augmentation and prevention of incisional hernia, including systems and methods for affixing mesh to a fascial incision. A mesh strip can be integrated with one or more uni-directional fasteners. Each fastener can include an anchoring mechanism adapted for affixation to anterior abdominal wall fascia and a mating... The Trustees Of The University Of Pennsylvania

11/09/17 / #20170319684

Novel artificial antigen presenting cells and uses thereof

The invention relates to novel artificial antigen presenting cells (aAPCs). The aAPC comprises at least one stimulatory ligand and at least one co-stimulatory ligand where the ligands each specifically bind with a cognate molecule on a T cell of interest, thereby mediating expansion of the T cell. The aAPC of... The Trustees Of The University Of Pennsylvania

11/09/17 / #20170319700

Drug-containing implants and methods of use thereof

The present invention provides implants comprising a therapeutic drug and a polymer containing polylactic acid (PLA) and optionally polyglycolic acid (PGA). The present invention also provides methods of maintaining a therapeutic level of a drug in a subject, releasing a therapeutic drug at a substantially linear rate, and treating schizophrenia... The Trustees Of The University Of Pennsylvania

11/09/17 / #20170322141

Measuring hiv reservoirs with optical scanning

Devices, systems and methods detect latent HIV in a patient on anti-retroviral therapy (ART), the method comprising using optical scanning to identify in a cell sample of the patient Gag+CD4 downregulated cells as in indication of latent HIV.... The Trustees Of The University Of Pennsylvania

11/02/17 / #20170312303

Compositions comprising ch848 envelopes and uses thereof

In certain aspects the invention provides immonogenic compositions comprising CH848 HIV-1 envelopes and their use in methods to induce immune responses in subjects, e.g., human subjects.... The Trustees Of The University Of Pennsylvania

10/26/17 / #20170304825

Apparatus and methods for manufacturing a microfluidic device

A microfluidic device includes an integrated circuit and a first substrate layer having a first surface and a second surface. The first surface of the first substrate layer is connected to the integrated circuit. The first substrate layer is in fluid communication with the integrated circuit. The microfluidic device also... The Trustees Of The University Of Pennsylvania

10/26/17 / #20170305971

Potent compstatin analogs

Compounds comprising peptides and peptidomimetics capable of binding C3 protein and inhibiting complement activation are disclosed. These compounds display greatly improved complement activation-inhibitory activity as compared with currently available compounds. Methods of making and using the compounds are also disclosed.... The Trustees Of The University Of Pennsylvania

10/26/17 / #20170306354

Adeno-associated virus (aav) serotype 8 sequences, vectors containing same, and uses therefor

Sequences of a serotype 8 adeno-associated virus and vectors and host cells containing these sequences are provided. Also described are methods of using such host cells and vectors in production of rAAV particles.... The Trustees Of The University Of Pennsylvania

10/26/17 / #20170306416

Biomarkers predictive of therapeutic responsiveness to chimeric antigen receptor therapy and uses thereof

Cancer biomarkers and methods of using them are disclosed.... The Trustees Of The University Of Pennsylvania

10/26/17 / #20170309025

Vivo detection of egfr mutation in glioblastoma via mri signature consistent with deep peritumoral infiltration

A method, including a computer-implemented method, is provided for in vivo detection of epidermal growth factor receptor (EGFR) mutation status within peritumoral edematous tissue of a patient. The method includes performing quantitative pattern analysis of magnetic resonance imaging (MRI) data corresponding to MRI of in vivo peritumoral edematous tissue to... The Trustees Of The University Of Pennsylvania

10/19/17 / #20170296675

Targeted carriers for intracellular drug delivery

The invention provides a method for delivering a cargo molecule into a cell using a targeted DNA-based carrier (e.g., DNA dendrimer). Compositions and kits useful in the practice of the methods are also provided.... The Trustees Of The University Of Pennsylvania

Patent Packs
10/19/17 / #20170296746

Methods, systems, and computer readable media for physiology parameter-invariant meal detection

Methods, systems, and computer readable media for physiology parameter-invariant meal detection are disclosed. According to one system, the system includes at least one processor and a meal detection module implemented using the at least one processor. The meal detection module is configured to receive insulin intake information and blood glucose... The Trustees Of The University Of Pennsylvania

10/19/17 / #20170298056

Small molecule inhibitors of hiv-1 entry and methods of use thereof

Described herein are small-molecule compounds that specifically inhibit a wide range of HIV-1 isolates without interfering with CD4 or CCR5 binding. Methods of using die compounds for treating or preventing HIV infection are also described.... The Trustees Of The University Of Pennsylvania

10/19/17 / #20170298388

Method of detecting and/or identifying adeno-associated virus (aav) sequences and isolating novel sequences identified thereby

Adeno-associated virus rh.20 sequences, vectors containing same, and methods of use are provided.... The Trustees Of The University Of Pennsylvania

10/19/17 / #20170298454

Compositions and methods for isolation of circulating tumor cells (ctc)

A method useful for identifying and isolating live circulating tumor cells is described. The method utilizes an adenoviral vector comprising a replication-competent adenovirus in which the E1 gene region is expressed under the control of a telomerase-specific promoter and further comprises a second expression cassette containing a marker protein, optionally... The Trustees Of The University Of Pennsylvania

10/19/17 / #20170299602

Biomimetic chemical sensors using nanoelectronic readout of olfactory receptors

The present invention provides biomimetic sensor devices that utilize proteins—such G-protein coupled receptors—and are useful in high-sensitivity analysis of analyte-containing samples. These sensors may be used to determine the presence or concentration of one or more analytes in a sample. The invention also includes methods of fabricating the devices and... The Trustees Of The University Of Pennsylvania

10/19/17 / #20170299732

Apparatus and methods for measuring delivered ionizing radiation

A dosimeter includes a substrate and a plurality of nanowire pairs located on the substrate. The plurality of nanowire pairs simulate a plurality of human chromosome pairs. A method of determining an effect of delivering ionizing radiation with a dosimeter having a substrate and a plurality of nanowire pairs located... The Trustees Of The University Of Pennsylvania

10/12/17 / #20170290858

Altering gene expression in modified t cells and uses thereof

The present invention relates to compositions and methods for generating a modified T cell with a nucleic acid capable of downregulating endogenous gene expression selected from the group consisting of TCR α chain, TCR β chain, beta-2 microglobulin and FAS further comprising a nucleic acid encoding a modified T cell... The Trustees Of The University Of Pennsylvania

10/12/17 / #20170291954

Glypican-3 antibody and uses thereof

The present invention relates to compositions and methods of isolated polynucleotides that encode or polypeptides comprising glypican-3 (GPC3). The invention also includes a chimeric antigen receptor (CAR) wherein the CAR is able to target GPC3. The invention further includes methods of treating a subject or diagnosing and treating diseases, disorders... The Trustees Of The University Of Pennsylvania

10/12/17 / #20170292132

Tissue preferential codon modified expression cassettes, vectors containing same, and uses thereof

Described herein are synonymously altered gene sequences which express protein in differing levels within secretory as compared to non-secretory target tissue. An expression cassette comprising an open reading frame (ORF) for a protein under the control of regulatory sequences which direct expression of the product in cell, which ORF has... The Trustees Of The University Of Pennsylvania

10/05/17 / #20170281691

Methods for constructing antibiotic resistance free vaccines

The present invention provides Listeria vaccine strains that express a heterologous antigen and a metabolic enzyme, and methods of generating same.... The Trustees Of The University Of Pennsylvania

10/05/17 / #20170281793

Anti-tem1 antibodies and uses thereof

The invention relates to Anti-TEM 1 antibodies or antigen-binding fragments thereof, yeast libraries comprising the same, and prophylactic, diagnostic, and therapeutic methods using the same.... The Trustees Of The University Of Pennsylvania

10/05/17 / #20170283775

Compositions and methods for treatment of cancer

The present invention provides compositions and methods for treating cancer in a human. The invention includes relates to administering a genetically modified T cell to express a CAR wherein the CAR comprises an antigen binding domain, a transmembrane domain, a costimulatory signaling region, and a CD3 zeta signaling domain.... The Trustees Of The University Of Pennsylvania

10/05/17 / #20170285124

Edema invariant tractography

Edema invariant tractography methods are provided. The methods include acquiring data using a multishell, high angular resolution diffusion imaging sequence; (ii) modeling the data using a multi-compartment model; and (iii) reconstructing the fibers through a probabilistic tracking algorithm using a fiber orientation distribution which has streamlines fitted to the output... The Trustees Of The University Of Pennsylvania

09/28/17 / #20170274014

Combinations of low, immune enhancing, doses of mtor inhibitors and cars

The invention relates, in part, to a method of treating a subject comprising administering to the subject a low, immune enhancing of a mTOR inhibitor and an immune effector cell engineered to express a CAR.... The Trustees Of The University Of Pennsylvania

09/28/17 / #20170275252

Asymmetric bisaminoquinolines and bisaminoquinolines with varied linkers as autophagy inhibitors for cancer and other therapy

The invention provides novel asymmetric and symmetric bisaminoquinolmes and related compounds, methods of treatment and syntheses. The novel compounds exhibit effective anticancer activity and are useful in the treatment of a variety of autophagy-related disorders.... The Trustees Of The University Of Pennsylvania

09/28/17 / #20170275686

Methods for detecting genomic dna methylation

The presently disclosed subject matter provides high-throughput methods for performing genomic DNA methylation assessments. The presently disclosed subject matter further provides methods for diagnosing a subject with a disease and/or disorder, and for determining the prognosis of a subject that has a disease and/or disorder. In certain embodiments, the present... The Trustees Of The University Of Pennsylvania

09/21/17 / #20170266282

Dna antibody constructs and using same

Disclosed herein is a composition including a recombinant nucleic acid sequence that encodes an antibody. Also disclosed herein is a method of generating a synthetic antibody in a subject by administering the composition to the subject. The disclosure also provides a method of preventing and/or treating disease in a subject... The Trustees Of The University Of Pennsylvania

09/21/17 / #20170266406

Nasal air jet insufflator

The present invention provides an apparatus for nasally delivering a supraglottic jet ventilation and methods of treating breathing disorders by utilizing the apparatus for nasally delivering a supraglottic jet ventilation.... The Trustees Of The University Of Pennsylvania

09/14/17 / #20170258776

Methods for treating disorders or diseases associated with hyperlipidemia and hypercholesterolemia while minimizing side effects

The present invention provides methods and compositions for treating hyperlipidemia and/or hypercholesterolemia comprising administering to the subject an effective amount of an MTP inhibitor to inhibit hyperlipidemia and/or hypercholesterolemia in said subject, wherein said administration comprises an escalating series of doses of the MTP inhibitor. In some embodiments the method... The Trustees Of The University Of Pennsylvania

09/14/17 / #20170258821

Use of secoisolariciresinol diglucosides (sdgs) and related compounds for protection against radiation and chemical damage

The invention provides compositions and methods for radioprotection and chemoprevention using therapeutic and prophylactics methods of using (S,S)-SDG (R,R)-SDG, (S,R)-SDG (R,S)-SDG, SDG, SECO, EL, ED, analogs thereof, stereoisomers thereof and other related molecules.... The Trustees Of The University Of Pennsylvania

09/14/17 / #20170258835

Methods and compositions for modified t cells

The present invention relates to compositions and methods for generating modified cells with nucleic acid encoding a T cell receptor (TCR), a nucleic acid encoding a bispecific antibody, affinity molecule chimeric receptor, bispecific affinity molecule, or a chimeric ligand engineered activation receptor (CLEAR). One aspect includes a method for generating... The Trustees Of The University Of Pennsylvania

09/14/17 / #20170258836

Compositions and methods of stimulating and expanding t cells

The present invention includes a method for expanding a population of electroporated T cells. The method includes electroporating a population of cells comprising T cells with mRNA encoding a chimeric membrane protein comprising an antigen binding domain to a molecule and an intracellular domain of a co-stimulatory molecule, wherein the... The Trustees Of The University Of Pennsylvania

09/14/17 / #20170258893

Mers-cov vaccine

Disclosed herein is a vaccine comprising a Middle East Respiratory Syndrome coronavirus (MERS-CoV) antigen. The antigen can be a consensus antigen. The consensus antigen can be a consensus spike antigen. Also disclosed herein is a method of treating a subject in need thereof, by administering the vaccine to the subject.... The Trustees Of The University Of Pennsylvania

09/14/17 / #20170258921

Protease triggered release of molecules from hydrogels

The invention relates to compositions comprising (i) biocompatible hydrogel and (ii) one or more therapeutic agents contained within said hydrogel; wherein the hydrogel is cross-linked utilizing a cross-linker comprising a peptide sequence that is capable of being degraded by an enzyme; the therapeutic agent being effective as a treatment of... The Trustees Of The University Of Pennsylvania

09/14/17 / #20170260221

Ruthenium-based photolinkers and methods of use

The present invention provides ruthenium-based photolinker compounds, caged molecules comprising the ruthenium-based photolinker compounds, and methods of use. In certain aspects, the compositions disclosed herein comprise an active domain conjugated to a ruthenium-based photolinker, such that irradiation of the photolinker exposes the active domain.... The Trustees Of The University Of Pennsylvania

09/14/17 / #20170260347

Nanocomposite films and methods for producing the same

A method of producing a nanocomposite film includes generating a bilayer film including at least a first layer of at least one nanoparticle and a second layer of at least one material and annealing the bilayer film. A uniform nanocomposite film includes a plurality of nanoparticles dispersed in a polymer... The Trustees Of The University Of Pennsylvania

09/14/17 / #20170261508

Methods for monitoring cd4+ t-helper type 1 response in cancer and immune restoration

A method for diagnosing or treating a mammalian subject having, or at risk of developing cancer, comprising: generating a circulating anti-cancer CD4+ Th1 response from antigen presenting cells or their precursors and CD4+ T-cells from a sample of said subject's blood which causes secretion of interferon-gamma (“IFN-γ”); and detecting said... The Trustees Of The University Of Pennsylvania








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