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The U s a As Represented By The Secretary Department Of Health And Human Services patents


Recent patent applications related to The U s a As Represented By The Secretary Department Of Health And Human Services. The U s a As Represented By The Secretary Department Of Health And Human Services is listed as an Agent/Assignee. Note: The U s a As Represented By The Secretary Department Of Health And Human Services may have other listings under different names/spellings. We're not affiliated with The U s a As Represented By The Secretary Department Of Health And Human Services, we're just tracking patents.

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 new patent  Human monoclonal antibodies specific for glypican-3 and use thereof

Described herein is the identification of human monoclonal antibodies that bind GPC3 or heparan sulfate (HS) chains on GPC3 with high affinity. The antibodies described herein are capable of inhibiting HCC cell growth and migration. Provided are human monoclonal antibodies specific for GPC3 or HS chains on GPC3, including immunoglobulin... The U s a As Represented By The Secretary Department Of Health And Human Services

Methods for the diagnosis and treatment of sjÖgren's syndrome

The finding that patients with Sjögren's syndrome exhibit a statistically significant increase in expression of BMP6 in the salivary gland relative to healthy control subjects is described. Also described is the finding that overexpression of BMP6 in the salivary glands of mice results in an increase in electrical potential across... The U s a As Represented By The Secretary Department Of Health And Human Services

Adeno-associated virus vectors encoding modified g6pc and uses thereof

Modified G6PC (glucose-6-phosphatase, catalytic subunit) nucleic acids and glucose-6-phosphatase-α (G6Pase-α) enzymes with increased phosphohydrolase activity are described. Also described are vectors, such as adeno-associated virus (AAV) vectors, and recombinant AAV expressing modified G6Pase-α. The disclosed AAV vectors and rAAV can be used for gene therapy applications in the treatment of... The U s a As Represented By The Secretary Department Of Health And Human Services

Topical sodium nitrite formulation

A sodium nitrite formulation for topical administration is described. The formulation includes an aqueous solution of non-acidified sodium nitrite dispersed in a white petrolatum ointment. The concentration of sodium nitrite in the formulation is about 0.5% to about 3.0% by weight. To prepare the formulation, non-acidified sodium nitrite is completely... The U s a As Represented By The Secretary Department Of Health And Human Services

Broad detection of dengue virus serotypes

Processes for detecting Dengue virus (DENV) nucleic acid in a sample are provided including producing an amplification product by amplifying DENV nucleotide sequence and detection of an amplification by hybridization of a probe or other technique. The processes use primers or probes with introduced mutations and or degenerate bases that... The U s a As Represented By The Secretary Department Of Health And Human Services

Biomarkers for diagnosis and management of neuro-immunological diseases

Biomarkers associated with neuroimmunological disease are described. The disclosed biomarkers are secreted proteins identified in cerebral spinal fluid (CSF) samples of patients with neurological disease. The disclosed biomarkers identify patients with intrathecal inflammation, distinguish multiple sclerosis (MS) patients from patients with other types of inflammatory neurological diseases and from subjects... The U s a As Represented By The Secretary Department Of Health And Human Services

Adeno-associated virus vectors for treatment of glycogen storage disease

The present disclosure describes improved adeno-associated virus (AAV) vectors for gene therapy applications in the treatment of glycogen storage disease, particularly glycogen storage disease type Ia (GSD-Ia). Described are recombinant nucleic acid molecules, vectors and recombinant AAV that include a G6PC promoter/enhancer, a synthetic intron, a G6PC coding sequence (such... The U s a As Represented By The Secretary Department Of Health And Human Services

Mesothelin-targeted chimeric antigen receptors and uses thereof

The presently disclosed subject matter provides for methods and compositions for enhancing the immune response toward cancers and pathogens. It relates to chimeric antigen receptors (CARs) that specifically target human mesothelin, and immunoresponsive cells comprising such CARs. The presently disclosed mesothelin-targeted CARs have enhanced immune-activating properties, including anti-tumor activity.... The U s a As Represented By The Secretary Department Of Health And Human Services

Engineered antibody constant domain molecules

Described herein are engineered antibody constant domain molecules, such as CH2 or CH3 domain molecules, comprising at least one mutation, or comprising at least one complementarity determining region (CDR), or a functional fragment thereof, engrafted in a loop region of the CH2 domain. The CH2 domain molecules described herein are... The U s a As Represented By The Secretary Department Of Health And Human Services








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