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The Uab Research Foundation
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The Uab Research Foundation patents


Recent patent applications related to The Uab Research Foundation. The Uab Research Foundation is listed as an Agent/Assignee. Note: The Uab Research Foundation may have other listings under different names/spellings. We're not affiliated with The Uab Research Foundation, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "T" | The Uab Research Foundation-related inventors


 new patent  Method of enhancing somatic cell reprogramming with the acetyllysine reader brd3r

A method of generating an induced pluripotent stem cell (ipsc) comprises introducing to an animal somatic cell at least one nuclear reprogramming inducing factor and a brd3r polypeptide or at least one nucleic acid expressing the at least one nuclear reprogramming factor and the brd3r-related polypeptide in the recipient somatic cell, and culturing said cell to generate an induced pluripotent stem cell (ipsc). The introduction of the brd3r-related polypeptide into the recipient somatic cell can increase the efficiency of inducing the generation of an ipsc by the at least one nuclear reprogramming inducing factor.. ... The Uab Research Foundation

Method and system for evaluating blood vessel

A method and system for evaluating physiological properties of a segment of blood vessel is provided. The method includes: acquiring a first measurement and a second measurement respectively at the first point and the second point; obtaining a transfer function configured to produce an output given an input, using the first measurement and the second measurement as the input and the output respectively; and determining the physiological properties of the section of the blood vessel based on the transfer function. ... The Uab Research Foundation

Fastening devices for landing string buoyancy and other solutions

Fastening devices are described. In one example, the fastening devices can be used for a landing string buoyancy solution. ... The Uab Research Foundation

Roneparstat combined therapy of multiple myeloma

The present invention relates to roneparstat for use in a combined therapy for the treatment of multiple myeloma. In particular it has unexpectedly been found that the combined use of roneparstat with a proteasome inhibitor, in particular selected between bortezomib and carfilzomib or with melphalan improve efficacy in decreasing the overall tumor burden, especially showing synergism, with respect to the administration of each active ingredient alone.. ... The Uab Research Foundation

Hypdh inhibitors and methods of use for the treatment of kidney stones

Provided herein are compounds of formula (i), formula (ii), and formula (iii), and compositions comprising the same, as well as methods of use thereof for controlling or inhibiting the formation of calcium oxalate kidney stones, inhibiting the production of glyoxylate and/or oxalate, and/or inhibiting hydroxyproline dehydrogenase (hypdh).. . ... The Uab Research Foundation

Multitargeting onocolytic adenovirus, methods of use, and methods of making

To increase the therapeutic potential of these oncolytic viruses based on a 24 base pair deletion in the viral e1 a gene (d24), a conditionally replicating adenovirus targeting multiple receptors upregulated on tumors was generated by incorporating an ad5/3 fiber with a carboxyl terminus rgd ligand. The virus displayed full cytopathic effect in tumor lines assayed at low titers with improved cytotoxicity over ad5-rgd d24, ad5/3 d24 and an hsv oncolytic virus. ... The Uab Research Foundation

Compositions and methods for inhibiting fibrosis

Provided herein are compositions and methods for treating or preventing fibrosis.. . ... The Uab Research Foundation

System and method for image registration of multiple video streams

Provided herein are methods and systems for image registration from multiple sources. A method for image registration includes rendering a common field of interest that reflects a presence of a plurality of elements, wherein at least one of the elements is a remote element located remotely from another of the elements and updating the common field of interest such that the presence of the at least one of the elements is registered relative to another of the elements.. ... The Uab Research Foundation

Protective helmets having energy absorbing liners

In one embodiment, a protective helmet includes an outer shell and an inner liner provided within the outer shell, the liner comprising an energy absorber including a first layer, an opposed second layer, and a plurality of energy absorbing columns provided between the layers, wherein the columns include relatively long columns that are attached to both the first and second layers and relatively short columns that are attached to only one of the first and second layers.. . ... The Uab Research Foundation

Protective helmets having energy absorbing tethers

In one embodiment, a tether system for use with a protective helmet worn by a user includes multiple tethers, each tether having a first end adapted to attach to a shell of the protective helmet and a second end adapted to attach to an article worn by the user, wherein the tethers limit movement of the helmet.. . ... The Uab Research Foundation

System and method for performing exercise testing and training

Disclosed are various approaches for determining the maximum oxygen consumption of a person, also known as maximum aerobic capacity or vo2 max. A person is positioned on a treadmill. ... The Uab Research Foundation

Protective helmets having energy absorbing shells

In one embodiment, a protective helmet includes an outer shell made of a polyethylene material, wherein the shell is locally deformable when impacted with a strong force and an inner liner provided within the outer shell. A protective helmet comprising: an outer shell made of a polyethylene material, wherein the shell is locally deformable when impacted with a strong force; and an inner liner provided within the outer shell.. ... The Uab Research Foundation

Methods for increasing cftr activity

The present disclosure provides compounds effective in increasing mucociliary clearance in a subject. In one embodiment, the compounds are of the general formula i. ... The Uab Research Foundation

Methods for preparing encapsulated markings on diamonds

In one aspect, the invention relates to methods to prepare markings on diamond surfaces which are encapsulated by diamond, and the marked diamonds prepared by the disclosed methods. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.. ... The Uab Research Foundation

09/14/17 / #20170261516

Methods and compositions for diagnosis and treatment of meningitis

The present invention provides a method of identifying meningitis as either bacterial meningitis or aseptic meningitis in a subject, comprising: a) measuring the amount of complement c3, complement factor b, complement membrane attack complex (mac) protein, complement c5b, complement c6, complement c7, complement c8, and/or complement c9 in a cerebrospinal fluid (csf) sample obtained from the subject; and b) comparing the amount of complement c3, complement factor b, complement mac protein, complement c5b, complement c6, complement c7, complement c8, and/or complement c9 measured in (a) with the amount of complement c3, complement factor b, complement mac protein, complement c5b, complement c6, complement c7, complement c8, and/or complement c9 measured in a control sample, wherein an amount of complement c3, complement factor b, complement mac protein, complement c5b, complement c6, complement c7, complement c8, and/or complement c9 measured in (a) that is greater than the amount of complement c3, complement factor b, complement mac protein, complement c5b, complement c6, complement c7, complement c8, and/or complement c9 measured in the control sample identifies the meningitis in the subject as bacterial meningitis.. . ... The Uab Research Foundation

08/31/17 / #20170248579

Amyotrophic lateral sclerosis (als) biomarkers and uses thereof

Provided herein are amyotrophic lateral sclerosis (als) biomarkers and methods of using these als biomarkers to diagnose and treat als.. . ... The Uab Research Foundation

08/03/17 / #20170218443

Msp nanopores and related methods

Provided herein are mycobacterium smegmatis porin nanopores, systems that comprise these nanopores, and methods of using and making these nanopores. Such nanopores may be wild-type mspa porins, mutant mspa porins, wild-type mspa paralog porins, wild-type mspa homolog porins, mutant mspa paralog porins, mutant mspa homolog porins, or single-chain msp porins. ... The Uab Research Foundation

07/27/17 / #20170210741

Benzimidazole compounds, use as inhibitors of wnt signaling pathway in cancers, and methods for preparation thereof

The present disclosure is concerned with benzimidazole compounds that are capable of inhibiting wnt signaling and methods of treating disease states such as, for example, cancer, using these compounds. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.. ... The Uab Research Foundation

07/13/17 / #20170197094

Systems and methods for providing radiotherapy treatment

In one embodiment, radiotherapy treatment is provided to a target volume of a patient by configuring a multileaf collimator of a radiation treatment machine in a first orientation so as to form an actual aperture having a first orientation, delivering radiation to the target volume through the actual aperture while in the first orientation with a single pass along an arcuate path centered on the target volume, configuring the multileaf collimator in a second orientation so as to place the actual aperture in a second orientation that is different from the first orientation, and delivering radiation to the target volume through the actual aperture while in the second orientation with a single pass back along the arcuate path such that a relatively large cumulative dose of radiation is delivered to the target volume through a virtual aperture created by an area of overlap between the first and second actual aperture orientations.. . ... The Uab Research Foundation

06/22/17 / #20170172825

Reclining transport chairs

A transport chair is provided that includes a base frame, a seat assembly pivotally mounted to the base, and a footrest assembly pivotally mounted to the base frame, the footrest assembly being associated with the seat assembly so as to pivot in unison with the seat assembly until the seat assembly is pivoted forward to an extent at which the footrest assembly contacts the floor or ground, at which point the footrest assembly does not pivot further upon further forward pivoting of the seat assembly. Further embodiments of the transport chair allow the seat assembly to recline, alone or in unison with a leg rest assembly, while the footrest remains in position.. ... The Uab Research Foundation

06/22/17 / #20170172243

Protective helmets for disaster situations

In one embodiment, a protective helmet for disaster situation includes a rigid outer shell and an electronic system integrated into the helmet that includes an electronic location system configured to transmit electromagnetic signals that can be used to locate the wearer of the helmet.. . ... The Uab Research Foundation

04/06/17 / #20170096698

Sumoylation assay and related reagents

Provided herein and methods and kits for identifying inhibitors of sumoylation. The provided methods include contacting a candidate agent with (i) a sumo-conjugating peptide comprising an n-terminal linker and a detectable tag, and (ii) a sumo comprising a metal complex, under conditions that allow binding between the sumo-conjugating peptide and the sumo, and detecting the detectable tag thereby determining the level of binding between the sumo-conjugating peptide and sumo. ... The Uab Research Foundation

03/23/17 / #20170082638

Methods and compositions for diagnosis and treatment of meningitis

The present invention provides a method of identifying meningitis as either bacterial meningitis or aseptic meningitis in a subject, comprising: a) measuring the amount of complement c3, complement factor b, complement membrane attack complex (mac) protein, complement c5b, complement c6, complement c7, complement c8, and/or complement c9 in a cerebrospinal fluid (csf) sample obtained from the subject; and b) comparing the amount of complement c3, complement factor b, complement mac protein, complement c5b, complement c6, complement c7, complement c8, and/or complement c9 measured in (a) with the amount of complement c3, complement factor b, complement mac protein, complement c5b, complement c6, complement c7, complement c8, and/or complement c9 measured in a control sample, wherein an amount of complement c3, complement factor b, complement mac protein, complement c5b, complement c6, complement c7, complement c8, and/or complement c9 measured in (a) that is greater than the amount of complement c3, complement factor b, complement mac protein, complement c5b, complement c6, complement c7, complement c8, and/or complement c9 measured in the control sample identifies the meningitis in the subject as bacterial meningitis.. . ... The Uab Research Foundation

02/02/17 / #20170029475

Msp nanopores and uses thereof

Provided herein are mutant single-chain mycobacterium smegmatis porin (msp) and uses thereof.. . ... The Uab Research Foundation

01/19/17 / #20170016191

Self-restoring crash cushions

In one embodiment, a self-restoring crash cushion including multiple diaphragms spaced along a length direction of the cushion, an elongated track adapted to be anchored to the ground that extends along the length direction under the cushion, the diaphragms being mounted to the track in a manner in which they can slide along the track when impacted by a moving vehicle or when the cushion is being restored, and means for dissipating energy of the moving vehicle.. . ... The Uab Research Foundation

01/19/17 / #20170014469

Methods of reactivating a latent human immunodeficiency virus

Provided herein are methods of reactivating a latent human immunodeficiency virus (hiv) infection in a cell or subject. The methods include contacting the cell with or administering to the subject one or more proteasome inhibitors, and contacting the cell with or administering to the subject one or more reactivating agents. ... The Uab Research Foundation

01/12/17 / #20170012423

Method for detecting an open-phase condition of a transformer

A method for detecting an open-phase condition of a transformer having a grounded-wye high voltage side connection including monitoring current flowing in a neutral connection on the high voltage side of the transformer in real time by voltage relaying and current relaying to identify an open phase condition signature in a signal capable of characterizing change of current magnitude. A current signal may be injected onto the neutral terminal and the zero-sequence mode of the transformer monitored to detect an open-phase condition indicated by an increase in network impedance and decrease or elimination of the injection current.. ... The Uab Research Foundation

01/05/17 / #20170002457

Composites comprising nanostructured diamond and metal boride films and methods for producing same

Composites having a substrate, a diamond film, and a metal boride film disposed between the substrate and the diamond film, together with methods for producing the composites.. . ... The Uab Research Foundation








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