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The United States Of America As Represented By The Secretary Department Of Health And Human Serv
The United States Of America As Represented By The Secretary Department Of Health And Human Service
The United States Of America As Represented By The Secretary Department Of Health And Human Services
The United States Of America As Represented By The Secretary Department Of Health And Human Servi
The United States Of America As Represented By The Secretary Department Of Health And Human Serv_20131212

The United States Of America As Represented By The Secretary Department Of Health And Human Serv patents


Recent patent applications related to The United States Of America As Represented By The Secretary Department Of Health And Human Serv. The United States Of America As Represented By The Secretary Department Of Health And Human Serv is listed as an Agent/Assignee. Note: The United States Of America As Represented By The Secretary Department Of Health And Human Serv may have other listings under different names/spellings. We're not affiliated with The United States Of America As Represented By The Secretary Department Of Health And Human Serv, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "T" | The United States Of America As Represented By The Secretary Department Of Health And Human Serv-related inventors


Cannabinoid receptor mediating compounds

A compound, or a pharmaceutically acceptable salt or ester thereof, comprising (i) a CB1 receptor mediating scaffold conjugated to (ii) a second therapeutic scaffold.... The United States Of America As Represented By The Secretary Department Of Health And Human Serv

Methods and surveillance and control of insect vectors

... The United States Of America As Represented By The Secretary Department Of Health And Human Serv

Methods of isolating t cells having antigenic specificity for a cancer-specific mutation

Disclosed are methods of isolating T cells having antigenic specificity for a mutated amino acid sequence encoded by a cancer-specific mutation, the method comprising: identifying one or more genes in the nucleic acid of a cancer cell of a patient, each gene containing a cancer-specific mutation that encodes a mutated... The United States Of America As Represented By The Secretary Department Of Health And Human Serv

Aerosol particle growth systems using polymer electrolyte membranes

Disclosed herein are aerosol particle growth systems including polymer electrolyte membranes and related methods of increasing the size of aerosol particles. In some embodiments, an outer housing contains a reservoir of a working fluid, and a PEM conduit extends through the outer housing, the reservoir, and the working fluid so... The United States Of America As Represented By The Secretary Department Of Health And Human Serv

 new patent  Rp2 and rpgr vectors for treating x-linked retinitis pigmentosa

Disclosed are adeno-associated virus (AAV) vectors comprising a nucleotide sequence encoding RP2 or RPGR-ORF15 and related pharmaceutical compositions. Also disclosed are methods of treating or preventing X-linked retinitis pigmentosa, increasing photoreceptor number in a retina of a mammal, and increasing visual acuity of a mammal using the vectors and pharmaceutical... The United States Of America As Represented By The Secretary Department Of Health And Human Serv

 new patent  Codon optimized il-15 and il-15r-alpha genes for expression in mammalian cells

The present invention further provides expression vectors, and IL-15 and IL-15 receptor alpha combinations (nucleic acid and protein) that increase IL-15 stability and potency in vitro and in vivo. The present methods are useful for the increased bioavailability and biological effects of IL-15 after DNA, RNA or protein administration in... The United States Of America As Represented By The Secretary Department Of Health And Human Serv

 new patent  Methods and reagents for detecting ebola virus

Probes and primers are disclosed for detecting EBOV nucleic acid in a sample. Methods are also disclosed that utilize these probes and primers, wherein the methods can be used to detect an EBOV in a sample to identify a subject with an EBOV infection.... The United States Of America As Represented By The Secretary Department Of Health And Human Serv

Diagnostic pediatric acute-onset neuropsychiatric syndrome (pans) and pediatric autoimmune neuropsychiatric disorder associated with streptococci infection (pandas)

The present invention provides a panel of at least five clinical analyses or tests (using serum samples) to determine the risk of pediatric acute-onset neuropsychiatric syndrome (PANS) and/or pediatric autoimmune neuropsychiatric disorder associated with streptococcal infection (PANDAS) in an individual. These include enzyme linked immunosorbent assays (ELISAs) to measure antibody... The United States Of America As Represented By The Secretary Department Of Health And Human Serv

Thermal inactivation of rotavirus

Methods of thermally inactivating a rotavirus are provided according to the present invention which include exposing the rotavirus to a temperature in the range of about 50° C.-80° C., inclusive, for an incubation time sufficient to render the rotavirus incapable of replication or infection. The thermally inactivated rotavirus is antigenic... The United States Of America As Represented By The Secretary Department Of Health And Human Serv

Myc g-quadruplex stabilizing small molecules and their use

Methods for treating a tumor, such as a benign or malignant tumor, are disclosed herein. The methods include administering a therapeutically effective amount of a small molecule that selectively binds to and stabilizes G-quadruplex DNA in the promoter of the c-MYC gene to the subject. The methods are also of... The United States Of America As Represented By The Secretary Department Of Health And Human Serv

Plasmodial surface anion channel inhibitors for the treatment or prevention of malaria

wherein Q, Y, R1, and R2 are as described herein. Methods of inhibiting a plasmodial surface anion channel of a parasite in an animal are also provided. The invention also provides pharmaceutical compositions comprising a compound represented by formula I in combination with any one or more compounds represented by... The United States Of America As Represented By The Secretary Department Of Health And Human Serv

Compounds and methods for treatment and prevention of flavivirus infection

The present invention concerns the use of compounds for the treatment or prevention of Flavivirus infections, such as Zika virus infections. Aspects of the invention include methods for treating or preventing Flavivirus virus infection, such as Zika virus infection, by administering a compound or class of compound disclosed herein, such... The United States Of America As Represented By The Secretary Department Of Health And Human Serv

Griffithsin mutants

The invention provides modified griffithsin polypeptides comprising the amino acid sequence of SEQ ID NO: 1, as well as corresponding nucleic acids, vectors, cells, fusion proteins, constructs, conjugates, and methods of inhibiting viral infection.... The United States Of America As Represented By The Secretary Department Of Health And Human Serv

Furoquinolinediones as inhibitors of tdp2

Compounds of Formula I and the pharmaceutically acceptable salts thereof are disclosed Formula I. The variables X1, X2, and R1-4 are disclosed herein. The compounds are useful for treating cancer and related proliferative diseases. Pharmaceutical compositions containing compounds of Formula I and methods of treatment comprising administering compounds of Formula... The United States Of America As Represented By The Secretary Department Of Health And Human Serv

Methods for identifying, diagnosing, and predicting survival of lymphomas

Gene expression data provides a basis for more accurate identification and diagnosis of lymphoproliferative disorders. In addition, gene expression data can be used to develop more accurate predictors of survival. The present invention discloses methods for identifying, diagnosing, and predicting survival in a lymphoma or lymphoproliferative disorder on the basis... The United States Of America As Represented By The Secretary Department Of Health And Human Serv

Human ebola virus species and compositions and methods thereof

Compositions and methods including and related to the Ebola Bundibugyo virus (EboBun) are provided. Compositions are provided that are operable as immunogens to elicit and immune response or protection from EboBun challenge in a subject such as a primate. Inventive methods are directed to detection and treatment of EboBun infection.... The United States Of America As Represented By The Secretary Department Of Health And Human Serv

Neutralizing antibodies to hiv-1 and their use

Monoclonal neutralizing antibodies are disclosed that specifically bind to the CD4 binding site of HIV-1 gp120. Monoclonal neutralizing antibodies also are disclosed that specifically bind to HIV-1 gp41. The identification of these antibodies, and the use of these antibodies are also disclosed. Methods are also provided for enhancing the binding... The United States Of America As Represented By The Secretary Department Of Health And Human Serv

Methanocarba derivatives of pseudoribose that inhibit adenosine kinase

where the moieties J and K, considered in combination, are —CH2—, or K and L, considered in combination, are —CH2—. The R1 moiety can be —NH2, C1-C6 alkyl, C1-C6 alkoxy, or C1-C6 hydroxyalkyl. The R2 and R3 moieties are each independently C1-C6 alkyl. The R4 moiety is hydrogen or C1-C6... The United States Of America As Represented By The Secretary Department Of Health And Human Serv

Lipoprotein targeting protease inhibitors and uses

Described herein is the design and construction of a class of lipoprotein targeting protease inhibitors. Small peptides with protease inhibitor activity are conjugated to hydrophobic, lipoprotein targeting molecules using, for instance, amine reactive chemistry. Methods of use of the resultant lipoprotein targeting protease inhibitor (antiprotease) molecules are also described. Also... The United States Of America As Represented By The Secretary Department Of Health And Human Serv

Novel crispr enzymes and systems

The invention provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides non-naturally occurring or engineered RNA-targeting systems comprising a novel RNA-targeting CRISPR effector protein and at least one targeting nucleic acid component like a guide RNA.... The United States Of America As Represented By The Secretary Department Of Health And Human Serv

Multi-focal structured illumination microscopy systems and methods

Various embodiments for a multi-focal selective illumination microscopy (SIM) system for generating multi-focal patterns of a sample are disclosed. The multi-focal SIM system performs a focusing, scaling and summing operation on each generated multi-focal pattern in a sequence of multi-focal patterns that completely scan the sample to produce a high... The United States Of America As Represented By The Secretary Department Of Health And Human Serv

Methods and compositions for the inhibition of pin1

The invention features compositions and methods for inhibiting the Pin1 protein, and the treatment of disorders characterized by elevated Pin1 levels.... The United States Of America As Represented By The Secretary Department Of Health And Human Serv

Polymer adjuvant

The invention relates to an adjuvant comprising Pattern Recognition Receptor (PRR) agonist molecules linked to polymer chains that are capable of undergoing particle formation in aqueous conditions, or in aqueous conditions in response to external stimuli; and methods of treatment or prevention of disease using such an adjuvant.... The United States Of America As Represented By The Secretary Department Of Health And Human Serv

Compounds for inhibiting drug-resistant strains of hiv-1 integrase

R8 and R9 is each independently H, optionally-substituted alkyl, optionally-substituted alkenyl, optionally-substituted alkynyl, optionally-substituted aryl, optionally-substituted cycloalkyl, optionally-substituted cycloalkylene, optionally-substituted heterocycle, optionally-substituted amide, optionally-substituted ester, or R8 and R9 together with the nitrogen to which R8 and R9 are attached form an optionally-substituted heterocycle.... The United States Of America As Represented By The Secretary Department Of Health And Human Serv

Immunogenic modulation by endocrine deprivation therapy improves sensitivity of tumor cells to immune mediated lysis

The invention is directed to methods of reducing growth of prostate cancer cells and breast cancer cells, which comprises treating such cancer cells with a combination of androgen or endocrine deprivation therapy (e.g., enzalutamide, abiraterone, and tamoxifen) and immunotherapy.... The United States Of America As Represented By The Secretary Department Of Health And Human Serv

Prefusion rsv f proteins and their use

Disclosed are immunogens including a recombinant RSV F protein stabilized in a prefusion conformation. Also disclosed are nucleic acids encoding the immunogens and methods of producing the immunogens. Methods for generating an immune response in a subject are also disclosed. In some embodiments, the method is a method for treating... The United States Of America As Represented By The Secretary Department Of Health And Human Serv

Substituted phenylpyrrolecarboxamides with therapeutic activity in hiv

Substituted phenylpyrrolecarboxamide compounds such as those represented by Formula A can be used in the treatment of HIV infection and related conditions.... The United States Of America As Represented By The Secretary Department Of Health And Human Serv

Chimeric antigen receptors to control hiv infection

The present disclosure is directed to novel multispecific chimeric antigen receptor (CAR) proteins and DNA sequences encoding these proteins. The CARs comprise at least two extracellular domains fused, via a transmembrane domain to a cytoplasmic signaling domain comprising two signaling domains. The disclosure further relates to nucleic acids encoding the... The United States Of America As Represented By The Secretary Department Of Health And Human Serv

Neutralizing antibodies to hiv-1 and their use

Monoclonal neutralizing antibodies that specifically bind to HIV-1 gp120 and antigen binding fragments of these antibodies are disclosed. Nucleic acids encoding these antibodies, vectors and host cells are also provided. Methods for detecting HIV using these antibodies are disclosed. In addition, the use of these antibodies, antigen binding fragment, nucleic... The United States Of America As Represented By The Secretary Department Of Health And Human Serv

Postnatal stem cells and uses thereof

The invention generally relates to postnatal dental stem cells and methods for their use. More specifically, the invention relates in one aspect to postnatal dental pulp stem cells, use of the cells to generate dentin, and differentiation of the cells. In another aspect, the invention relates to human postnatal deciduous... The United States Of America As Represented By The Secretary Department Of Health And Human Serv

Peptide-based methods for treating pancreatic cancer

Methods for treating pancreatic cancer via administration of small anti-inflammatory peptides. The peptides may be administered in conjunction with another therapeutic agent or therapeutic regimen.... The United States Of America As Represented By The Secretary Department Of Health And Human Serv

Soluble engineered monomeric fc

Fc domains and CH3 domains are disclosed that bind the neonatal Fc (FcRn) receptor and are at least 99% monomeric. Monomeric Fc domain molecules and CH3 domain molecules are disclosed herein that include a monomeric Fc domain or a monomeric CH3 domain and an effector molecule. In some embodiments, the... The United States Of America As Represented By The Secretary Department Of Health And Human Serv

Segmented metallic guidewires

Disclosed herein are embodiments of segmented metallic guidewires that are suitable for MRI catheterization. Disclosed guidewires comprise a plurality of short conductive metallic segments that individually are short enough such that they do not resonate during MRI. The conductive segments are electrically insulated from each other and mechanically coupled together... The United States Of America As Represented By The Secretary Department Of Health And Human Serv

Infectious hepatitis c viruses of genotype 3a and 4a and uses thereof

The present invention relates to molecular approaches to the production of nucleic acid sequences, which comprises the genome of infectious hepatitis C virus. In particular, the invention provides nucleic acid sequences which comprise the genomes of infectious hepatitis C viruses of either genotype 3a (strain S52) or genotype 4a (strain... The United States Of America As Represented By The Secretary Department Of Health And Human Serv

Recombinant hiv-1 envelope proteins and their use

HIV-1 Env ectodomain trimers stabilized in a prefusion mature closed conformation and methods of their use and production are disclosed. In several embodiments, the HIV-1 Env ectodomain trimers and/or nucleic acid molecules can be used to generate an immune response to HIV-1 in a subject. In additional embodiments, the therapeutically... The United States Of America As Represented By The Secretary Department Of Health And Human Serv

08/03/17 / #20170216398

Pseudomonas exotoxin a with less immunogenic b cell epitopes

The invention provides a Pseudomonas exotoxin A (PE) comprising an amino acid sequence having a substitution of one or more of amino acid residues E420, D463, Y481, L516, R563, D581, D589, and K606, wherein the amino acid residues are defined by reference to SEQ ID NO: 1. The invention further... The United States Of America As Represented By The Secretary Department Of Health And Human Serv

07/20/17 / #20170202977

Polyketal particles including a cpg oligodeoxynucleotide for the treatment of lung cancer

The methods include locally administering to the subject a therapeutically effective amount of the polyketal particle comprising a CpG oligodexoynucleotide. Optionally, the polyketal particle can include an imidazoquinoline compound.... The United States Of America As Represented By The Secretary Department Of Health And Human Serv

07/20/17 / #20170205409

Hpv16 antibodies as diagnostic and prognostic biomarkers in pre-invasive and invasive disease

Methods and systems for detection of HPV mediated cervical or oropharyneal cancer are provided. The methods include contacting a fluid sample from a patient with multiple antibodies to HPV16 early gene proteins and comparing patterns of HPV16 antibody bound to said early gene proteins with a control associated with cervical... The United States Of America As Represented By The Secretary Department Of Health And Human Serv

07/20/17 / #20170205413

Methods of diagnosing and prognosing colonic polyps

Methods of diagnosing or prognosing a disease or condition associated with increased or over expression of macrophage inhibitory cytokine-1 (MIC-1) are disclosed. The methods typically involve detecting a change in the amount of MIC-1 in a test body sample from a subject taken at two or more time points. The... The United States Of America As Represented By The Secretary Department Of Health And Human Serv

07/13/17 / #20170196911

Reducing cxcr4 expression and/or function to enhance engraftment of hematopoietic stem cells

Provided herein are methods of enhancing engraftment of hematopoietic stem cells (HSC) in recipient subjects by reducing expression (or activity) of CXC chemokine receptor 4 (CXCR4). Such methods can be used in gene therapy protocols and in HSC transplantation, for example allowing this to occur without radiation or chemotherapy conditioning... The United States Of America As Represented By The Secretary Department Of Health And Human Serv

06/22/17 / #20170173144

Human rotavirus vaccine strains and diagnostics

Immunogenic pharmaceutical compositions including a live, attenuated human rotavirus or an inactivated human rotavirus are provided which are useful for inducing an immunological response against the rotavirus in a subject. Methods of inducing an immunological response to a rotavirus in a subject are provided by administering an immunogenic pharmaceutical composition... The United States Of America As Represented By The Secretary Department Of Health And Human Serv

06/22/17 / #20170174639

Eis inhibitors

Provided herein are novel small-molecules that have use in the inhibition of Eis, which mediates kanamycin resistance in Mycobacterium tuberculosis. The presently-disclosed subject matter further includes a pharmaceutical composition including a small molecule inhibitor, as described herein, and a suitable pharmaceutical carrier. Methods of treating tuberculosis comprising administering to an... The United States Of America As Represented By The Secretary Department Of Health And Human Serv

06/22/17 / #20170174771

Anti-epidermal growth factor receptor variant iii chimeric antigen receptors and use of same for the treatment of cancer

The invention provides chimeric antigen receptors (CARs) comprising an antigen binding domain of human antibody 139, an extracellular hinge domain, a transmembrane domain, and an intracellular domain T cell receptor signaling domain. Nucleic acids, recombinant expression vectors, host cells, populations of cells, antibodies, or antigen binding portions thereof, and pharmaceutical... The United States Of America As Represented By The Secretary Department Of Health And Human Serv

06/08/17 / #20170160279

Assay to measure midkine or pleiotrophin level for diagnosing a growth

The invention provides methods and kits for diagnosing a growth in a subject by providing a sample of a growth taken from a subject, determining the level of midkine or pleiotrophin in the sample by an immunoassay, and comparing the level of midkine or pleiotrophin determined from the sample with... The United States Of America As Represented By The Secretary Department Of Health And Human Serv

06/01/17 / #20170151191

Intranasal administration of ketamine to treat depression

Methods and compositions for the treatment of treatment-resistant depression are described. More specifically, the invention demonstrates that intranasal administration of ketamine is effective to ameliorate the symptoms of depression in a patient who has not responded to an adequate trial of one antidepressant in the current episode and has recurrent... The United States Of America As Represented By The Secretary Department Of Health And Human Serv

06/01/17 / #20170151310

Complexes of il-15 and il-15ralpha and uses thereof

The present invention relates to agents that modulate interleυkin-15 (“IL-15”) signal transduction or function (“Therapeutic Agents”) and the use ol” those agents to modulate immune function. The Therapeutic Agents target the interaction between IL-15 and its receptor and modulate IL-15-induced signal transduction. The Therapeutic Agents may be formulated with polymers,... The United States Of America As Represented By The Secretary Department Of Health And Human Serv

05/25/17 / #20170143745

Inhibition of hiv infection through chemoprophylaxis

A process is provided for protecting a primate host from a self-replicating infection by an immunodeficiency retrovirus. Protection is achieved by administering to the primate host a combination of a pharmaceutically effective amount of a nucleoside reverse transcriptase inhibitor and a pharmaceutically effective amount of a nucleotide reverse transcriptase inhibitor... The United States Of America As Represented By The Secretary Department Of Health And Human Serv

05/25/17 / #20170145480

Selective detection of haemophilus influenzae

A process for detecting Haemophilus influenzae nucleic acid in a sample includes producing an amplification product by amplifying a Haemophilus influenzae nucleotide sequence and measuring the amplification product to detect Haemophilus influenzae in the sample. Some embodiments allow direct serotype determination in a single step assay. Also provided are reagents... The United States Of America As Represented By The Secretary Department Of Health And Human Serv

05/11/17 / #20170128535

Tslp induces neutrophil mediated killing of methicillin-resistant staphylococcus aureus

The invention also provides a method of treating blood product, which comprises introducing a TSLP protein or polypeptide into such blood product, wherein the blood product is extracorporeal and comprises at least one neutrophil.... The United States Of America As Represented By The Secretary Department Of Health And Human Serv

05/11/17 / #20170128562

Polyvalent influenza virus-like particles (vlps) and use as vaccines

This disclosure provides compositions that include a mixture of viral like particles (VLPs), expressing different individual influenza hemagglutinin (HA) proteins that elicit broadly reactive immune responses to a wide variety of influenza viruses. For example, the composition can include at least two different influenza VLPs, a first VLP comprising a... The United States Of America As Represented By The Secretary Department Of Health And Human Serv

05/11/17 / #20170130246

Trans-acting elements for intracellular delivery of nucleic acid sequences

provided that when x is 5-6, the number of positively charged linkages is 3, when x is 7-8, the number of positively charged linkages is 3-4, when x is 9-12, the number of positively charged linkages is 3-10, and when x is 13-20, the number of positively charged linkages is... The United States Of America As Represented By The Secretary Department Of Health And Human Serv

05/04/17 / #20170119881

Combination therapies targeting tumor-associated stroma or tumor cells and microtubules

The present invention provides, inter alia, methods for treating or ameliorating the effects of a disease, such as cancer, in a subject. The methods include: administering to a subject in need thereof (a) a therapeutically effective amount of a microtubule inhibitor; and (b) a therapeutically effective amount of a monoclonal... The United States Of America As Represented By The Secretary Department Of Health And Human Serv

05/04/17 / #20170119882

Combination therapies targeting tumor-associated stroma or tumor cells

The present invention provides, inter alia, methods for treating or ameliorating the effects of a disease, such as cancer, in a subject. The methods include: administering to a subject in need thereof (a) a therapeutically effective amount of an agent selected from the group consisting of an anti-angiogenic agent, a... The United States Of America As Represented By The Secretary Department Of Health And Human Serv

05/04/17 / #20170119883

Combination therapies using platinum agents and agents that target tumor-associated stroma or tumor cells

Methods, pharmaceutical compositions, and kits for treating a disease, such as cancer, in a subject. The methods include: administering to a subject in need thereof (a) a therapeutically effective amount of a platinum agent; and (b) a therapeutically effective amount of a monoclonal antibody or antigen binding fragment thereof.... The United States Of America As Represented By The Secretary Department Of Health And Human Serv

05/04/17 / #20170122853

Photo-controlled removal of targets in vitro and in vivo

This disclosure provides IR700-molecule conjugates and methods of their use to remove (e.g., separate or isolate) a target from a sample in vivo or from a subject in vitro. It is shown herein that exposure of IR700 to near infrared (NIR) light removes a portion of IR700, changing it from... The United States Of America As Represented By The Secretary Department Of Health And Human Serv

04/27/17 / #20170112926

Combination therapies using anti-metabolites and agents that target tumor-associated stroma or tumor cells

The present invention provides, inter alia, methods for treating or ameliorating the effects of a disease, such as cancer, in a subject. The methods include: administering to a subject in need thereof (a) a therapeutically effective amount of an agent selected from an anti-metabolite agent or analog thereof and combinations... The United States Of America As Represented By The Secretary Department Of Health And Human Serv

04/27/17 / #20170112928

Combination therapies targeting tumor-associated stroma or tumor cells and topoisomerase

The present invention provides, inter alia, methods for treating or ameliorating the effects of a disease, such as cancer, in a subject. The methods include: administering to a subject in need thereof (a) a therapeutically effective amount of a topoisomerase inhibitor; and (b) a therapeutically effective amount of a monoclonal... The United States Of America As Represented By The Secretary Department Of Health And Human Serv

04/27/17 / #20170114053

Heterocyclic compounds and methods of use thereof

Disclosed are compounds of formula (I), formula (II), and formula (III): wherein Ar, R1, A, and X are as defined in the specification. These compounds are antiviral agents and are contemplated for use in the treatment of viral infections, for example, hepatitis C. These compounds are also contemplated for use... The United States Of America As Represented By The Secretary Department Of Health And Human Serv

04/20/17 / #20170105941

Nanoparticulate complex of nicotine and cerium oxide and use thereof

Disclosed are particles comprising a complex of nicotine and cerium oxide and a biodegradable coating comprising agglutinin. Also disclosed is a method of treating or preventing neurodegenerative or neurological disorders in a mammal in need thereof, comprising administering to the mammal a therapeutically effective amount of the particles.... The United States Of America As Represented By The Secretary Department Of Health And Human Serv

04/20/17 / #20170107286

Chimeric antigen receptors targeting cd-19

The invention is directed to a chimeric antigen receptor (CAR) directed against CD19, which comprises an amino acid sequence of any one of SEQ ID NO: 1-SEQ ID NO: 13. The invention also provides T-cells expressing the CAR and methods for destroying malignant B-cells.... The United States Of America As Represented By The Secretary Department Of Health And Human Serv

04/06/17 / #20170095575

Combination therapies using agents that target tumor-associated stroma or tumor cells and other pathways

The present invention provides, inter alia, methods for treating or ameliorating the effects of a disease, such as cancer in a subject. The methods include: administering to a subject in need thereof (a) a therapeutically effective amount of a molecularly targeted agent; and (b) a therapeutically effective amount of a... The United States Of America As Represented By The Secretary Department Of Health And Human Serv

03/30/17 / #20170089995

Magnetic resonance 2d relaxometry reconstruction using partial data

An approach is presented to recontruct image data for an object using a partial set of magnetic resonance (MR) measurements. A subset of data points in a data space representing an object are selected (e.g. through random sampling) for MR data acquisition. Partial MR data corresponding to the subset of... The United States Of America As Represented By The Secretary Department Of Health And Human Serv

03/23/17 / #20170081276

Preparation of (r,r)-fenoterol and (r,r)- or (r,s)-fenoterol analogues and their use in treating congestive heart failure

This disclosure concerns the discovery of (R,R)- and (R,S)-fenoterol analogues which are highly effective at binding β2-adrenergic receptors. Exemplary chemical structures for these analogues are provided. Also provided are pharmaceutical compositions including the disclosed (R,R)-fenoterol and fenoterol analogues, and methods of using such compounds and compositions for the treatment of... The United States Of America As Represented By The Secretary Department Of Health And Human Serv

03/09/17 / #20170067800

Miniature serial sectioning microtome for block-face imaging

The present disclosure is directed to embodiments of microtome devices and methods of their use. In some embodiments, a microtome can be mounted on the built-in stage of a scanning electron microscope and used to perform serial block-face scanning electron microscopy. In some cases, a microtome installed in a scanning... The United States Of America As Represented By The Secretary Department Of Health And Human Serv

03/02/17 / #20170058366

Hiv-2 nucleic acids and methods of detection

Disclosed herein are methods of detecting HIV-2 nucleic acids in a sample (such as from a sample infected with or suspected to be infected with HIV-2). In some examples, the methods include LAMP or RT-LAMP, while in other examples, the methods include hybridization of a probe to an HIV-2 nucleic... The United States Of America As Represented By The Secretary Department Of Health And Human Serv

Patent Packs
03/02/17 / #20170058367

Real-time pcr point mutation assays for detecting hiv - 1 resistance to antiviral drugs

Disclosed are compositions including primers and probes, which are capable of interacting with the disclosed nucleic acids, such as the nucleic acids encoding the reverse transcriptase or protease of HIV as disclosed herein. Thus, provided is an oligonucleotide comprising any one of the nucleotide sequences set for in SEQ ID... The United States Of America As Represented By The Secretary Department Of Health And Human Serv

02/23/17 / #20170051008

Androstane and pregnane steroids with potent allosteric gaba receptor chloride ionophore modulating properties

This invention describes compounds of Structures 1, 2, and 3 and their use as allosteric modulators of the GABA receptor chloride ionophore complex to alleviate stress, anxiety, mood disorders, seizures, depression, treatment of drug and alcohol abuse, memory, premenstrual disorders, and neural system damage.... The United States Of America As Represented By The Secretary Department Of Health And Human Serv

02/23/17 / #20170051072

Modified pseudomonas exotoxin a

The invention provides a Pseudomonas exotoxin A (PE) comprising an amino acid sequence having a substitution of one or more B-cell and/or T-cell epitopes. The invention further provides related chimeric molecules, as well as related nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions. Methods of... The United States Of America As Represented By The Secretary Department Of Health And Human Serv

02/23/17 / #20170052185

Biomarkers for prostate cancer and methods for their detection

The invention provides a method for predicting the clinical response to a cancer vaccine in a patient having cancer, a method for determining the immune response to a cancer vaccine in a patient having cancer who has been administered a cancer vaccine, a method for determining the long-term survival in... The United States Of America As Represented By The Secretary Department Of Health And Human Serv

02/02/17 / #20170029483

Murine anti-ny-eso-1 t cell receptors

The invention provides an isolated or purified T cell receptor (TCR) having antigenic specificity for NY-ESO-1. Also provided are related polypeptides, proteins, nucleic acids, recombinant expression vectors, isolated host cells, populations of cells, antibodies, or antigen binding portions thereof, and pharmaceutical compositions. The invention further provides a method of detecting... The United States Of America As Represented By The Secretary Department Of Health And Human Serv

02/02/17 / #20170030911

Compositions and methods relating to lyme disease

Compositions and methods of the present invention relating to B. burgdorferi HtrA sensu lato (BbHtrA) protease activity, its substrates, cleavage products, biological effects and use in detection, diagnosis and/or treatment of Lyme disease are provided.... The United States Of America As Represented By The Secretary Department Of Health And Human Serv

01/19/17 / #20170014637

System with an electromagentic field generator with coils for treating tumors and a treating tissue

Treatment apparatus includes a plurality of coils configured to generate time-varying magnetic fields that induce electric fields within a subject. In one example, electric field strengths of at least 1 V/cm are produced in brain tissues exhibiting Glioblastoma Multiforme (GBM). Fields are applied based on computer-assisted modeling using electromagnetic characteristics... The United States Of America As Represented By The Secretary Department Of Health And Human Serv

01/05/17 / #20170002007

A3 adenosine receptor agonists

Disclosed are compounds of the formula (I) and (II) which are A3 adenosine receptor agonists, pharmaceutical compositions comprising such compounds, and a method of use of these compounds, wherein X, Y, Z, R2-R6, and R103-R106 are as defined in the specification. These compounds are selective to the A3 receptor, and... The United States Of America As Represented By The Secretary Department Of Health And Human Serv








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