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The United States Of America As Represented By The Secretary Dept Of Health And Human Services
The United States Of America As Represented By The Secretary Dept Of Health And Human Services_20100121

The United States Of America As Represented By The Secretary Dept Of Health And Human Services patents


Recent patent applications related to The United States Of America As Represented By The Secretary Dept Of Health And Human Services. The United States Of America As Represented By The Secretary Dept Of Health And Human Services is listed as an Agent/Assignee. Note: The United States Of America As Represented By The Secretary Dept Of Health And Human Services may have other listings under different names/spellings. We're not affiliated with The United States Of America As Represented By The Secretary Dept Of Health And Human Services, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "T" | The United States Of America As Represented By The Secretary Dept Of Health And Human Services-related inventors


Tagged form of mut enzyme, genetic constructs incorporating it, and its use in gene thereapy

Disclosed are polynucleotides, polypeptides, and gene therapy vectors relating to biologically active methylmalonyl-CoA mutase enzymes, internally tagged with an immunoaffinity and detection epitope, which has been designed and tested in mouse models of methylmalonic acidemia (MMA). The polypeptides and polynucleotides of the present invention contain a mitochondrial leader sequence fused... The United States Of America As Represented By The Secretary Dept Of Health And Human Services

Wirelessly powered magnetic resonance imaging signal amplification system

An implantable parametric circuit enables local signal amplification and wireless transmission of RF signals in connection with magnetic resonance imaging systems. The parametric circuit detects RF signal detected during magnetic resonance imaging procedure, amplifies the detected RF signal, and transmits the amplified RF signal in a wireless manner to an... The United States Of America As Represented By The Secretary Dept Of Health And Human Services

Ratio based biomarkers and methods of use thereof

Compositions, methods and kits are described for identifying biomolecules (e.g., proteins and nucleic acids) expressed in a biological sample that are associated with the presence, development, or progression of a disease (such as cancer), or more generally determination of the etiology or risk factors associated with a disease. Sample types... The United States Of America As Represented By The Secretary Dept Of Health And Human Services

Chimeric antigen receptors targeting b-cell maturation antigen

The invention provides an isolated and purified nucleic acid sequence encoding a chimeric antigen receptor (CAR) directed against B-cell Maturation Antigen (BCMA). The invention also provides host cells, such as T-cells or natural killer (NK) cells, expressing the CAR and methods for destroying multiple myeloma cells.... The United States Of America As Represented By The Secretary Dept Of Health And Human Services

Biomarkers for malaria diagnosis

Disclosed herein are methods of detecting Plasmodium in a subject (for example, presence of Plasmodium parasite) by detecting the presence and/or amount of one or more metabolites in a sample from the subject. In some embodiments, the methods include detecting in the sample one or more metabolites listed in Table... The United States Of America As Represented By The Secretary Dept Of Health And Human Services

Cannabinoid receptor mediating compounds

A compound, or a pharmaceutically acceptable salt or ester thereof, comprising (i) a CB1 receptor mediating scaffold conjugated to (ii) a second therapeutic scaffold.... The United States Of America As Represented By The Secretary Dept Of Health And Human Services

Development of mutations useful for attenuating dengue viruses and chimeric dengue viruses

A menu of mutations was developed that is useful in fine-tuning the attenuation and growth characteristics of dengue virus vaccines.... The United States Of America As Represented By The Secretary Dept Of Health And Human Services

Methods and compositions for inhibiting polyomavirus-associated pathology

Disclosed herein are methods of eliciting an immune response against a polyomavirus (for example, BKV serotype I (BKV-I), BKV serotype II (BKV-II), BKV serotype III (BKV-III) and/or BKV serotype IV (BKV-IV)) and methods of treating or inhibiting polyomavirus-associated pathology (such as polyomavirus-associated nephropathy, BKV-associated hemorrhagic cystitis, or JC virus-associated progressive... The United States Of America As Represented By The Secretary Dept Of Health And Human Services

Cd47 targeted therapies for the treatment of infectious disease

Methods are provided for treating a subject with for an intracellular pathogen infection, by administering an agent that reduces the binding of CD47 on a infected cell to SIRPα on a host phagocytic cell, in an effective dose for increasing the phagocytosis of infected cells.... The United States Of America As Represented By The Secretary Dept Of Health And Human Services

Synthetic methylmalonyl-coa mutase transgene for the treatment of mut class methylmalonic acidemia (mma)

Synthetic polynucleotides encoding human methylmalonyl-CoA mutase (synMUT) and exhibiting augmented expression in cell culture and/or in a subject are described herein. An adeno-associated viral (AAV) gene therapy vector encoding synMUT under the control of a liver-specific promoter (AAV2/8-HCR-hAAT-synMUT-RBG) successfully rescued the neonatal lethal phenotype displayed by methylmalonyl-CoA mutase-deficient mice, lowered... The United States Of America As Represented By The Secretary Dept Of Health And Human Services

Vascular endothelial growth factor antagonists

The present invention provides variant VEGF polypeptides which have been altered in their C-terminal heparin binding region to lower their heparin binding affinity. These variants have been found to act as receptor antagonists for VEGF receptors and antagonize angiogenesis. These variants are useful to treat diseases characterized by pathological angiogenesis.... The United States Of America As Represented By The Secretary Dept Of Health And Human Services

Compounds and methods for the prevention and treatment of tumor metastasis and tumorigenesis

The disclosure provides compounds for reducing the prevalence of the perinucleolar compartment in cells, for example, of formula (I), wherein R1, R2, R3, and R4 are as defined herein, that are useful in treating a disease or disorder associated with increased prevalence of the perinucleolar compartment, such as cancer. Also... The United States Of America As Represented By The Secretary Dept Of Health And Human Services

Phantom for diffusion mri imaging

A phantom calibration body (12) for calibrating diffusion MRI device (16) that mimics a material such as a mammalian tissue is disclosed. The phantom calibration body (12) includes a homogeneous aqueous solution (30) that contains a mixture of low molecular-weight and high molecular-weight polymers housed in a container (14) that... The United States Of America As Represented By The Secretary Dept Of Health And Human Services

Thio compounds

wherein A, B and D are each oxygen or sulfur, provided that least one of A, B and D is sulfur; and R1-R8 are each independently hydrogen, hydroxyl, acyl, substituted acyl, acyloxy, substituted acyloxy, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, alkoxy, substituted alkoxy, aryl, substituted aryl, amino,... The United States Of America As Represented By The Secretary Dept Of Health And Human Services

System and real-time processing of medical imaging raw data using cloud computing

The present invention relates to a system and apparatus for managing and processing raw medical imaging data.... The United States Of America As Represented By The Secretary Dept Of Health And Human Services

Cell lines for virus production and methods of use

... The United States Of America As Represented By The Secretary Dept Of Health And Human Services

Inhibitors of the farnesoid x receptor and uses in medicine

Disclosed are inhibitors of the farnesoid X receptor, for example of formula (I), wherein R1, R2, R4, X, Y, Z, m, and n are as defined herein, which are useful in treating or preventing obesity, type 2 diabetes/insulin resistance and non-alcoholic fatty liver disease in a mammal in need thereof.... The United States Of America As Represented By The Secretary Dept Of Health And Human Services

Ratio based biomarkers and methods of use thereof

Compositions, methods and kits are described for identifying biomolecules (e.g., proteins and nucleic acids) expressed in a biological sample that are associated with the presence, development, or progression of a disease (such as cancer), or more generally determination of the etiology or risk factors associated with a disease. Sample types... The United States Of America As Represented By The Secretary Dept Of Health And Human Services

Chimeric west nile/dengue viruses and methods of use

Disclosed herein are chimeric flaviviruses including non-coding regions, non-structural proteins, and at least a portion of a C protein from West Nile virus (WNV), and a prM protein and an E protein from Dengue virus (DENV). The DENV may be DEN1 serotype, DEN2 serotype, DEN3 serotype, or DEN4 serotype. Also... The United States Of America As Represented By The Secretary Dept Of Health And Human Services

Synthetic methylmalonyl-coa mutase transgene for the treatment of mut class methylmalonic acidemia (mma)

Synthetic polynucleotides encoding human methylmalonyl-CoA mutase (synMUT) and exhibiting augmented expression in cell culture and/or in a subject are described herein. An adeno-associated viral (AAV) gene therapy vector encoding synMUT under the control of a liver-specific promoter (AAV2/8-HCR-hAAT-synMUT-RBG) successfully rescued the neonatal lethal phenotype displayed by methylmalonyl-CoA mutase-deficient mice, lowered... The United States Of America As Represented By The Secretary Dept Of Health And Human Services

Methods for treating progeroid laminopathies using oligonucleotide analogues targeting human lmna

Provided are methods of treatment in subjects having progeroid diseases and related conditions which rely upon LMNA-targeted antisense oligonucleotides for reducing expression of one or more aberrantly spliced LMNA mRNA isoforms that encode progerin.... The United States Of America As Represented By The Secretary Dept Of Health And Human Services








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