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The University Of Chicago patents


Recent patent applications related to The University Of Chicago. The University Of Chicago is listed as an Agent/Assignee. Note: The University Of Chicago may have other listings under different names/spellings. We're not affiliated with The University Of Chicago, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "T" | The University Of Chicago-related inventors


Device and method for pressure-driven plug transport and reaction

The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.. ... The University Of Chicago

Nanoparticles for photodynamic therapy, x-ray induced photodynamic therapy, radiotherapy, radiodynamic therapy, chemotherapy, immunotherapy, and any combination thereof

Metal-organic frameworks (mofs) comprising photosensitizers are described. The mofs can also include moieties capable of absorbing x-rays or other ionizing irradiation energy and/or scintillation. ... The University Of Chicago

Synthetic substrates for enzymes that catalyze reactions of modified cysteines and related methods

Synthetic probes for detecting the activity of enzymes that catalyze reactions of post-translationally modified cysteine residues are described. The probes include “turn-on” probes that include a carbamate linkage that is cleaved via an intramolecular reaction with a free thiol produced by an enzyme catalyzed activity. ... The University Of Chicago

Compositionally matched molecular solders for semiconductors

Chalcogenidometallates of group iib, iv and v elements and, particularly, alkali metal-containing chalcogenidometallates of cadmium, lead and bismuth are provided. Also provided are methods of using the chalcogenidometallates as molecular solders to form metal chalcogenide structures, including thin films, molded objects and bonded surfaces composed of metal chalcogenides.. ... The University Of Chicago

Reporting tool with integrated lesion stager

A device and method integrates a lesion stager in a reporting tool. The method includes receiving a user input. ... The University Of Chicago

Il13ra2 binding agents and use thereof in cancer treatment

Provided are specific binding molecules, or fragments thereof, that bind to an epitope of il13rα2, a receptor polypeptide preferentially found on the surface of cancer cells rather than healthy cells. Exemplary specific binding molecules are bispecific binding molecules that comprise a fragment of an il13rα2 binding molecule and a peptide providing a second function providing a signaling function of the signaling domain of a t cell signaling protein, a peptide modulator of t cell activation, or an enzymatic component of a labeling system. ... The University Of Chicago

Method of forming topcoat for patterning

Disclosed is a method for the fabrication of polymeric topcoat via initiated chemical vapor deposition (icvd) or photoinitiated chemical vapor deposition (picvd) in conjunction with directed self-assembly (dsa) of block copolymers to generate high resolution patterns. A topcoat deposited by icvd or picvd allows for conformal, ultra-thin, uniform, pinhole-free coatings. ... The University Of Chicago

Methods for determining prognosis for breast cancer patients

Described herein are methods for treating breast cancer and for providing a prognosis for metastatic-free survival of breast cancer patients. Aspects relate to treating a patient determined to be at high risk for developing or having metastatic breast cancer comprising administering adjuvant or neoadjuvant therapy to the patient determined to be at high risk for developing or having metastatic breast cancer, wherein the patient was determined to be at high risk for developing or having metastatic breast cancer by determining that the expression level of rkip was reduced and/or the expression level of one or more of hmga2, ccl5, tn-fr2, grn, and ccl7 was elevated in a biological sample from the patient compared to a control non-metastatic tissue sample.. ... The University Of Chicago

Particles containing an opioid receptor antagonist and methods of use

Particles comprising an opioid receptor antagonist as well as methods of their use and methods of their preparation are provided herein. Such particles may be used for treating and preventing opioid-induced side effects in patients, and may be provided to chronic opioid users as well.. ... The University Of Chicago

System for the production of methane from co2

A method of converting co2 gas produced during industrial processes comprising contacting methanogenic archaea with the co2 gas under suitable conditions to produce methane.. . ... The University Of Chicago

Compositions and methods for identifying endogenous dna-dna interactions

Provided herein are compositions and methods for identifying endogenous dna-dna interactions. In particular, compositions and methods are provided for performing capture of associated targets on chromatin (catch) assays which use efficient capture and enrichment of specific genomic loci of interest through hybridization and subsequent purification via complementary oligonucleotides, without the need for enzymatic digestion or ligation steps.. ... The University Of Chicago

Enzymatically-cleavable peptide amphiphiles

Provided herein are enzymatically-cleavable peptide amphiphiles and methods of use thereof.. . ... The University Of Chicago

Mutant hsp70i to prevent autoimmune disease

Methods of treating autoimmune diseases, such as vitiligo, by using compositions comprising dna encoding a variant inducible heat shock protein 70 (hsp70i) having a mutation in the dendritic cell binding region thereof (hsp70i435-447) or an isolated variant gene product in the form of hsp70i with a modification in the dendritic cell activating region thereof (hsp70i435-447).. . ... The University Of Chicago

Automatically detecting distributed concurrency errors in cloud systems

A method for detecting distributed concurrency errors in a distributed cloud computing system includes tracing operations that access objects in functions involving inter-process messaging, applying a set of happens-before rules to the traced operations. Analyzing the traced operations to identify concurrent operations that access a common object to generate a list of potential distributed concurrency errors (dcbugs). ... The University Of Chicago

02/15/18 / #20180044385

Methods and compositions involving protein g variants

Methods and compositions are provided concerning polypeptides with modifications that increase its binding affinity for the fab region of an antibody. Methods include using the polypeptides for isolating, detecting, purifying, measuring and quantifying fab polypeptides. ... The University Of Chicago

02/08/18 / #20180038868

Beta-catenin inhibitors in cancer immunotherapy

Provided herein are compositions and methods for the treatment of cancer by inhibition of β-catenin or a β-catenin pathway. In particular, inhibitors of β-catenin and/or the wnt/p-catenin signaling pathway are employed prevent or reverse evasion of immune response or immuno-therapy by cancers.. ... The University Of Chicago

02/08/18 / #20180037889

Antisense polynucleotides to induce exon skipping and methods of treating dystrophies

Antisense polynucleotides and their use in pharmaceutical compositions to induce exon skipping in targeted exons of the gamma sarcoglycan gene are provided, along with methods of preventing or treating dystrophic diseases such as limb-girdle muscular dystrophy.. . ... The University Of Chicago

02/08/18 / #20180036380

Treatments for migraine and related disorders

Embodiments are directed to compositions and methods of treating migraine and related neurological disorders. In certain aspects, methods and compositions are for reducing cortical spreading depression and/or suppressing the neurochemical basis for chronic and acute migraine events, and provide methods and pharmaceutical compositions related to both acute and preventive therapies for migraine events and related headaches.. ... The University Of Chicago

02/08/18 / #20180036318

Methods are directed to the treatment of subjects with prostate cancer, in particular those with castration resistant prostate cancer, with glucocorticoid receptor antagonists. The prostate cancer may be one that has become resistant to androgen deprivation therapy, for example, by increase in glucocorticoid receptor expression and/or activity.. ... The University Of Chicago

02/01/18 / #20180028224

Mallet with radiolucent head

This disclosure includes embodiments of mallets with radiolucent heads to permit radiologic imaging of a device (e.g., needle) as the device is being positioned with the mallet, as well as methods of using such a mallet, and methods of imaging a device while it is being positioned with such a mallet.. . ... The University Of Chicago

02/01/18 / #20180027808

Methods, formulations, and kits for bacterial degradation

Methodologies, formulations, and kits suitable for decontaminating environments containing bacterial spores by degrading the spores. Formulations contain papain and at least one germinant. ... The University Of Chicago

01/18/18 / #20180015131

Treatment of cancer by manipulation of commensal microflora

Provided herein are methods of treatment and/or prevention of cancer by manipulation of commensal microflora. In particular, the amount, identity, presence, and/or ratio of microflora (e.g., gut microflora) in a subject is manipulated to facilitate one or more co-treatments.. ... The University Of Chicago

01/11/18 / #20180008594

Use of opioid antagonists

Embodiments of the invention provide methods of attenuating, e.g., inhibiting or reducing, cellular proliferation and migration, particularly endothelial cell proliferation and migration, including that associated with angiogenesis, as well as attenuating cancerous tumor growth and metastasis, using opioid antagonists, including, but not limited to, those that are peripherally restricted antagonists.. . ... The University Of Chicago

12/28/17 / #20170369847

Tissues containing semiconductor nanomaterials and methods of preparing and using the same

Provided herein are tissues containing semiconductor nanomaterials and methods of preparing and using the same.. . ... The University Of Chicago

12/28/17 / #20170369536

Compositions and methods related to protein a (spa) variants

The present invention concerns methods and compositions for treating or preventing a bacterial infection, particularly infection by a staphylococcus bacterium. The invention provides methods and compositions for stimulating an immune response against the bacteria. ... The University Of Chicago

12/28/17 / #20170368551

Device and method for pressure-driven plug transport and reaction

The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.. ... The University Of Chicago

12/21/17 / #20170364101

Microfluidic system

The present invention provides microfluidic technology enabling rapid and economical manipulation of reactions on the femtoliter to microliter scale.. . ... The University Of Chicago

12/21/17 / #20170363607

Amorphous, porous silicon materials and related methods

Provided herein are si-based materials, methods of making the si-based materials, and methods for using the si-based materials. In embodiments, a silicon-based material comprises an aggregate of particles, the particles comprising an ordered array of nanostructures, the nanostructures comprising amorphous silicon, wherein at least some pairs of adjacent nanostructures are connected by one or more bridges comprising amorphous silicon, the one or more bridges extending from the surface of one nanostructure of the pair to the surface of the other nanostructure in the pair.. ... The University Of Chicago

12/21/17 / #20170362460

Resin composition for forming a phase-separated structure, and method of producing structure containing phase-separated structure

A resin composition for forming a phase-separated structure, including: a block copolymer, and an ion liquid containing a compound (il) having a cation moiety and an anion moiety, the energy of the lumo of the cation moiety being −4.5 ev or more, and the energy difference between the lumo and the homo of the cation moiety being 10.0 ev or more, or the log p value of the anion moiety being 1 to 3.. . ... The University Of Chicago

12/21/17 / #20170361321

Device and method for pressure-driven plug transport and reaction

The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.. ... The University Of Chicago

12/21/17 / #20170360931

Methods and composition for neutralization of influenza

Provided herein are compositions useful for neutralization of influenza virus, and methods of use and manufacture thereof. In particular, compositions comprising antibodies that are cross-reactive with multiple influenza strains are provided, as well as methods of treatment and prevention of influenza infection therewith.. ... The University Of Chicago

12/14/17 / #20170355648

Synthesis of meta-substituted [18f]-3-fluoro-4-aminopyridines by direct radiofluorination of pyridine n-oxides

Disclosed herein are methods for the fluorination aromatic n-heterocyclic n-oxides that comprise at least one leaving group. The n-oxides may be reduced to the fluorinated aromatic n-heterocyclic amine analogs. ... The University Of Chicago

11/30/17 / #20170343252

Systems and methods for providing continuous cooling at cryogenic temperatures

Systems and methods of continuous cooling at cryogenic temperatures. One exemplary aspect involves a refrigeration system that includes: a chamber adapted to hold liquid and gaseous coolant received from a cooling pot; a first adsorption pump having an inlet end in fluid communication with the chamber, the first adsorption pump configured to capture gas from the liquid and gaseous coolant when the first adsorption pump is enabled; a second adsorption pump having an inlet end in fluid communication with the chamber, the second adsorption pump configured to capture gas from the liquid and gaseous coolant when the second adsorption pump is enabled; a means for desorbing the gas captured by the first adsorption pump; and a means for desorbing the gas captured by the second adsorption pump.. ... The University Of Chicago

11/09/17 / #a backlight unit including:

University Of Chicago

. . ... The University Of Chicago

10/26/17 / #20170306386

Yeast screens for treatment of human disease

Screening methods for identifying substances that provide therapeutic value for various diseases associated with protein misfolding are provided. Genetic and chemical screening methods are provided using a yeast system. ... The University Of Chicago

10/26/17 / #20170306004

Compositions and methods related to antibodies that neutralize coagulase activity during staphylococcus aureus disease

Embodiments concern methods and compositions for treating or preventing a bacterial infection, particularly infection by a staphylococcus bacterium. Aspects include methods and compositions for providing a passive immune response against the bacteria. ... The University Of Chicago

10/26/17 / #20170305981

Synthetic peptides

Provided herein are compositions comprising synthetic lipase-stimulating peptides, and methods of treating hyper-triglyceridemia and other conditions and diseases therewith. In particular, synthetic peptides (av-peptides) and peptidomimetics (av-peptidomimetics) are provided that exhibit the lipase-stimulating activity of apoa-v or an enhancement thereof, as well as methods of use thereof. ... The University Of Chicago

10/26/17 / #20170304281

Methods of using potassium channel inhibitors (blockers) for fluid resuscitation

Methods and pharmaceutical treatments of fluid resuscitation in which a selective potassium channel inhibitor is administered to a patient in a therapeutic amount sufficient to stabilize blood pressure and/or to reduce the amount of the resuscitation fluid otherwise required to resuscitate the patient.. . ... The University Of Chicago

10/05/17 / #20170281668

Materials and methods for preventing and treating microbe-mediated epithelial disorders

The present invention provides pharmaceutical compositions in the form of relatively high molecular weight biocompatible polymers such as polyethylene glycol, optionally supplemented with a protective polymer such as dextran and/or essential pathogen nutrients such as l-glutamine. Also provided are methods for preventing or treating gut-derived sepsis attributable to intestinal pathogens such as pseudomonas aeruginosa by administering high molecular weight polyethylene glycol as well as methods for monitoring the administration of high molecular weight polyethylene glycol, such as in methods of preventing, ameliorating or treating microbe-induced epithelial disorders, as exemplified by gut-derived sepsis. ... The University Of Chicago

09/28/17 / #20170278687

Batch production of microchannel plate photo-multipliers

In-situ methods for the batch fabrication of flat-panel micro-channel plate (mcp) photomultiplier tube (pmt) detectors (mcp-pmts), without transporting either the window or the detector assembly inside a vacuum vessel are provided. The method allows for the synthesis of a reflection-mode photocathode on the entrance to the pores of a first mcp or the synthesis of a transmission-mode photocathode on the vacuum side of a photodetector entrance window.. ... The University Of Chicago

09/21/17 / #20170268036

Oligonucleotide-mediated quantitative multiplexed immunoassays

Methods and compositions for quantitative immunoassays are provided, in which ligand-conjugated probes are used to label samples and ligand-surfaced microspheres are used as quantitative reference standards. Certain embodiments provide a method of quantitative flow cytometry where ligands are oligonucleotides, and a sample comprising one or more cells is contacted with a hybridized antibody::fluorophore labeled targeting construct to label the cells, and the labeled cells are analyzed. ... The University Of Chicago

09/21/17 / #20170268001

Rnas with tumor radio/chemo-sensitizing and immunomodulatory properties and methods of their preparation and application

Compositions, kits and methods for treating cancer in a subject in need thereof are disclosed involving one or more genes the suppression of which renders the cancer chemosensitive and/or radiosensitive.. . ... The University Of Chicago

09/14/17 / #20170261949

Apparatus and method for optimizing quantifiable behavior in configurable devices and systems

An apparatus and method are provided to perform constrained optimization of a constrained property of an apparatus, which is complex due to having several components, and these components are configurable in real-time. The optimization is achieved by detecting values of the constrained property and a plurality of other properties of the apparatus when the apparatus is configured in a first subset of the plurality of configurations. ... The University Of Chicago

09/14/17 / #20170261835

Semiconductor system with transitional metal impurity for quantum information processing

Methods and devices are disclosed for implementing quantum information processing based on electron spins in semiconductor and transition metal compositions. The transition metal electron orbitals split under semiconductor crystal field. ... The University Of Chicago

09/14/17 / #20170258909

Use of opioid antagonists to attenuate endothelial cell proliferation and migration

The invention provides methods of attenuating, e.g., inhibiting or reducing, cellular proliferation and migration, particularly endothelial cell proliferation and migration, including that associated with angiogenesis, using opioid antagonists, including, but not limited to, those that are peripherally restricted antagonists.. . ... The University Of Chicago

09/07/17 / #20170252336

Use of opioid antagonists to attenuate endothelial cell proliferation and migration

The invention provides methods of attenuating, e.g., inhibiting or reducing, cellular proliferation and migration, particularly endothelial cell proliferation and migration, including that associated with angiogenesis, using opioid antagonists, including, but not limited to, those that are peripherally restricted antagonists.. . ... The University Of Chicago

08/24/17 / #20170240767

Resin composition for forming a phase-separated structure, and method of producing structure containing phase-separated structure

A resin composition for forming a phase-separated structure, including a block copolymer, and an ion liquid containing a compound having a cation moiety and an anion moiety, the anion moiety being represented by general formula (a1), (a2) or (a3), in which x″ represents an alkylene group of 2 to 6 carbon atoms in which at least one hydrogen atom is substituted with a fluorine atom; y″ and z″ each independently represents an alkyl group of 1 to 10 carbon atoms in which at least one hydrogen atom is substituted with a fluorine atom; r″ represents an alkyl group of 1 to 5 carbon atoms in which at least one hydrogen atom is optionally substituted with a fluorine atom, m represents an integer of 1 to 6, and n represents an integer of 0 to 5, provided that m+n=6.. . ... The University Of Chicago

08/24/17 / #20170240766

Resin composition for forming a phase-separated structure, and method of producing structure containing phase-separated structure

A resin composition for forming a phase-separated structure, including: a block copolymer, and an ion liquid containing a compound (il) having a cation moiety and an anion moiety, the cation moiety of the compound (il) having a dipole moment of 3 debye or more.. . ... The University Of Chicago

08/17/17 / #20170232440

Device and method for pressure-driven plug transport and reaction

The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.. ... The University Of Chicago

08/17/17 / #20170231903

Nanoparticles for photodynamic therapy, x-ray induced photodynamic therapy, radiotherapy, chemotherapy, immunotherapy, and any combination thereof

Metal-organic frameworks (mofs) comprising photosensitizers are described. The mofs can also include moieties capable of absorbing x-rays and/or scintillation. ... The University Of Chicago

08/03/17 / #20170218055

Compositions and methods related to antibodies to staphylococcal protein a

Embodiments concern methods and compositions for treating or preventing a bacterial infection, particularly infection by a staphylococcus bacterium. Aspects include methods and compositions for providing a passive immune response against the bacteria. ... The University Of Chicago

07/20/17 / #20170202832

Use of methylnaltrexone to attenuate tumor progression

Presented herein are methods for preventing or treating tumor growth, tumor metastasis and/or abnormal proliferation of tumor cells in a subject, wherein the methods involve administration of a pharmaceutical composition comprising methylnaltrexone. Also presented herein are methods for inhibiting or slowing the growth of a tumor in a subject, wherein the methods include selecting a subject who is a suitable candidate for treatment with methylnaltrexone, and administering a composition comprising methylnaltrexone to the subject.. ... The University Of Chicago

06/29/17 / #20170182486

Metal-organic frameworks containing nitrogen-donor ligands for efficient catalytic organic transformations

Metal-organic framework (mofs) compositions based on nitrogen donor-based organic bridging ligands, including ligands based on 1,3-diketimine (nacnac), bipyridines and salicylaldimine, were synthesized and then post-synthetically metalated with metal precursors, such as complexes of first row transition metals. Metal complexes of the organic bridging ligands could also be directly incorporated into the mofs. ... The University Of Chicago

06/29/17 / #20170182066

Methods and compositions related to glucocorticoid receptor antagonists and breast cancer

Embodiments of the invention are directed to methods of determining the prognosis of a breast cancer patient by evaluating the activity of the glucocorticoid receptor in tumor cells. Other embodiment include methods of treating breast cancer cells, particularly, chemo-resistant cells, with a glucocorticoid receptor antagonist and an anticancer agent or compound.. ... The University Of Chicago

06/22/17 / #20170174629

Use of fluorinated derivatives of 4-aminopyridine in therapeutics and medical imaging

The present disclosure provides novel compounds, including compounds that bind to potassium channels, methods for their manufacture, and methods for their use, including their use to diagnose and/or assess traumatic brain injury and use to treat dymeylinating diseases, and/or in vivo imaging of the central neverous system, and to diagnose and/or assess the progression of ms or other diseases.. . ... The University Of Chicago

06/15/17 / #20170166652

Chimeric antigen receptors recognizing cancer-specific tn glycopeptide variants

Disclosed are binding proteins, or fragments thereof, that specifically binds to a cancer-specific glycosylation variant of a protein and to a second epitope on the same protein, to a different protein presented on the same cell, or to a different protein presented on a different cell, such as an encoded polypeptide binding to both a cancer cell and an activated t cell. Also disclosed are polynucleotides encoding such binding proteins, including polynucleotides comprising codon-optimized coding regions and polynucleotides comprising coding regions that are not codon-optimized for expression in a particular host cell. ... The University Of Chicago

05/18/17 / #20170137484

Methods and compositions for cancer therapy using mutant light molecules with increased affinity to receptors

Methods and compositions are disclosed to target tumor cells with embodiments of the light proteins linked fused or conjugated to a targeting agent. These compositions bind to both human and mouse receptors with affinity sufficient to conduct preclinical and clinical trials, and with increased affinity as compared to the wild type human light protein. ... The University Of Chicago

03/23/17 / #20170081670

Methods for modulating klhl1 levels, methods for modulating current activity in t-type calcium channels, molecules therefor, and methods for identifying molecules therefor

Methods for modulating t-type calcium channel activity without directly targeting the t-type calcium channels are provided that include modulating kelch-like protein 1 (klhl1) levels in a subject by providing a small hairpin rna (shrna) that targets a klhl1 gene, and then administering the shrna to the subject in an amount sufficient to modulate klhl1 gene expression. The klhl1 level directly effects current activity in t-type calcium channels and therefore modulation of klhl1 gene expression indirectly modulates current activity in t-type calcium channels. ... The University Of Chicago

03/09/17 / #20170065581

Treatment with opioid antagonists and mtor inhibitors

Embodiments of the invention provide methods of treating a disorder or disease characterized by cellular proliferation and migration by co-administering a synergistically effective amount of an mtor inhibitor and a μ-opioid receptor antagonist.. . ... The University Of Chicago

03/02/17 / #20170061613

Contrast medium uptake time computation using magnetic resonance imaging

A computing device determines a contrast medium uptake time using magnetic resonance imaging data. Image data constructed from data generated by a magnetic resonance imaging (mri) machine of a subject is read. ... The University Of Chicago

01/19/17 / #20170014360

Methods of treating cancer using rad51 small molecule stimulators

Methods of killing or inhibiting the growth cancer cells and tumors and of treating cancer by administering compounds that stimulate the activity of rad51. Cells overexpressing rad51 or with other imbalances in homologous recombination machinery are particularly susceptible targets of rad51 stimulators.. ... The University Of Chicago

01/05/17 / #20170002334

Direct evolution of a regioselective halogenase for increased thermostability

Compounds and methods are providing involving rebh variants with improved properties. Directed evolution based on random mutagenesis was employed to generate a series of rebh variants. ... The University Of Chicago








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