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The University Of North Carolina At Chapel Hill patents


Recent patent applications related to The University Of North Carolina At Chapel Hill. The University Of North Carolina At Chapel Hill is listed as an Agent/Assignee. Note: The University Of North Carolina At Chapel Hill may have other listings under different names/spellings. We're not affiliated with The University Of North Carolina At Chapel Hill, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "T" | The University Of North Carolina At Chapel Hill-related inventors


Water soluble nitric oxide-releasing polyglucosamines and uses thereof

The presently disclosed subject matter provides nitric oxide-releasing polysaccharides and oligosaccharides, in particular, polyglucosamines, and their use in biomedical and pharmaceutical applications. More particularly, in some embodiments, the presently disclosed subject matter provides nitric oxide-releasing polysaccharides and oligosaccharides that release nitric oxide in a controlled and targeted manner, thereby prolonging the therapeutic effects of nitric oxide and improving the specificity of nitric oxide delivery to targeted cells and/or tissues.. ... The University Of North Carolina At Chapel Hill

Pressure driven fluidic injection for chemical separations by electrophoresis

A pneumatic method, and associated apparatus, for injecting a discrete sample plug into the separation channel of an electrophoresis microchip (100) is disclosed. In a first step, pressurized gas (90) is applied to the sample (30) and background electrolyte (20) reservoirs such that the pressure is higher there than at the sample waste reservoir (35) to create a focused sample stream at the junction between the sample and separation channels. ... The University Of North Carolina At Chapel Hill

Bispecific molecules comprising an hiv-1 envelope targeting arm

The invention is directed to bispecific molecules comprising an hiv-1 envelope targeting arm and an arm targeting an effector cell, compositions comprising these bispecific molecules and methods of use. In certain aspects, the bispecific molecules of the present invention can bind to two different targets or epitopes on two different cells wherein the first epitope is expressed on a different cell type than the second epitope, such that the bispecific molecules can bring the two cells together. ... The University Of North Carolina At Chapel Hill

Photoredox-catalyzed direct c-h functionalization of arenes

The invention generally relates to methods of making substituted arenes via direct c—h amination. More specifically, methods of making para- and ortho-substituted arenes via direct c—h amination are disclosed. ... The University Of North Carolina At Chapel Hill

Methods and compositions for treatment of heart failure

The present invention relates to methods and compositions for treating heart failure in a subject using histone deacetylase (hdac) inhibitors and/or histone acetyltransferases (hat) activators.. . ... The University Of North Carolina At Chapel Hill

Integrated sample processing for electrospray ionization devices

Methods, systems and devices that generate differential axial transport in a fluidic device having at least one fluidic sample separation flow channel and at least one esi emitter in communication with the at least one sample separation flow channel. In response to the generated differential axial transport, the at least one target analyte contained in a sample reservoir in communication with the sample separation channel is selectively transported to the at least one esi emitter while inhibiting transport of contaminant materials contained in the sample reservoir toward the at least one esi emitter thereby preferentially directing analyte molecules out of the at least one esi emitter. ... The University Of North Carolina At Chapel Hill

The University Of North Carolina At Chapel Hill

. . ... The University Of North Carolina At Chapel Hill

Methods for fabricating isolated micro- or nano-structures using soft or imprint lithography

The presently disclosed subject matter describes the use of fluorinated elastomer-based materials, in particular perfluoropolyether (pfpe)-based materials, in high-resolution soft or imprint lithographic applications, such as micro- and nanoscale replica molding, and the first nano-contact molding of organic materials to generate high fidelity features using an elastomeric mold. Accordingly, the presently disclosed subject matter describes a method for producing free-standing, isolated nanostructures of any shape using soft or imprint lithography technique.. ... The University Of North Carolina At Chapel Hill

The University Of North Carolina At Chapel Hill

. . ... The University Of North Carolina At Chapel Hill

Methods, systems, and computer readable media for image overlap detection

Methods, systems, and computer readable media for image overlap detection. An example method includes identifying, by one or more computers, a collection of images; streaming, by the one or more computers, each image from the collection of images so that, in one or a limited number of passes through the collection of images, each image is loaded only once from an input source and each image is discarded after a processing time for the image is exceeded; and during the streaming, for each image in at least a first subset of the images in the collection, determining whether the image overlaps with at least one other image in the at least a first subset of the images.. ... The University Of North Carolina At Chapel Hill

Methods and compositions for synthetic rna endonucleases

The present invention provides sequence specific restriction enzymes for site-specific cleavage of rna, as well as methods of their use.. . ... The University Of North Carolina At Chapel Hill

Activatable crispr/cas9 for spatial and temporal control of genome editing

Disclosed herein is a genetically encoded light- or chemically-activated cas9 engineered through the site-specific installation of an activatable lysine amino acid. Such activatable cas9 proteins can be used in crispr/cas9 systems to control gene expression temporally, spatially, or both. ... The University Of North Carolina At Chapel Hill

Polymeric microneedles and rapid additive manufacturing of the same

The invention generally relates to microneedle devices, methods of making same, pharmaceutical compositions comprising same, and methods of treating a disease comprising administering same. Specifically, the disclosed microneedle devices comprise a plurality of biocompatible microneedles having one or more of: (i) a curved, discontinuous, undercut, and/or perforated sidewall; (ii) a sidewall comprising a breakable support; and (iii) a cross-section that is non-circular and non-polygonal. ... The University Of North Carolina At Chapel Hill

Delivery vehicles for stem cells and uses thereof

Provided herein according to some embodiments is a biocompatible scaffold comprising stem cells (e.g., a pliable scaffold) suitable for intracavity administration after surgical removal of a tumor, wherein the scaffold allows the stem cells to migrate away from the scaffold and towards a cancerous or damaged tissue, wherein the stem cells are loaded with a therapeutic agent and/or a reporter molecule. Methods of forming the scaffold, and methods of use thereof, are also provided.. ... The University Of North Carolina At Chapel Hill

03/01/18 / #20180055792

Polymeric metformin and its use as a therapeutic agent and as a delivery vehicle

Provided herein are polymers comprising metformin residues (“polymet”) as useful therapeutic agents, delivery vehicles and transfection agents for nucleotides. Also provided herein are methods for the treatment of a disease or an unwanted condition in a subject, wherein the methods comprise administering polymet as a therapeutic agent to combat the disease or condition. ... The University Of North Carolina At Chapel Hill

02/22/18 / #20180051249

Methods for making neural stem cells and uses thereof

Provided herein according to some embodiments is a method for producing an induced neural stem cell (insc), which method may include one or more of the steps of: providing a somatic cell; introducing into (e.g., by transfecting or transducing) said somatic cell with a nucleic acid encoding sox2, whereby said cell expresses sox2; and then transdifferentiating said somatic cell (e.g., by growing the cell in a neural progenitor medium), to thereby make said induced neural stem cell. In some embodiments, the transdifferentiating is carried out for a time of from 1 to 10 days, from 1 to 5 days, from 1 to 3 days, or from 12 to 24 or 48 hours.. ... The University Of North Carolina At Chapel Hill

02/22/18 / #20180049410

Ephemeral substrates for oyster aquaculture

Provided is novel ephemeral substrate material for growing oysters that alleviates concerns related to adding large quantities of permanent fill to estuarine water and promotes high rates of oyster survival and growth, high meat quality and market-favorable shell-shape of cultured oysters, along with artificial oyster growing structures prepared from the ephemeral substrate material and methods of using the same.. . ... The University Of North Carolina At Chapel Hill

02/15/18 / #20180045843

Acoustic imaging with expandable microcapsules

The present disclosure relates generally to expandable microcapsules and their utilization for acoustic imaging within a geological formation. The present disclosure further relates to expandable microcapsules with a multicomponent core and disclosure to practical utilization of multicomponent cores for controlling the expansion properties (e.g., temperature and pressure of expansion, expansion volume ratio, and shell thickness) of the resulting microbubbles.. ... The University Of North Carolina At Chapel Hill

01/18/18 / #20180016584

Methods and compositions for unsilencing imprinted genes

The present invention provides methods and compositions for inducing expression of ube3a in a cell by contacting the cell with a topoisomerase inhibitor. Particular embodiments include a method of treating a genomic imprinting disorder, such as angelman syndrome, in a subject by administering to the subject an effective amount of a topoisomerase inhibitor.. ... The University Of North Carolina At Chapel Hill

01/18/18 / #20180016340

Monoclonal antibodies for enhancing or inhibiting insulin-like growth factor 1 (igf-1)

The present invention provides an antibody or antigen-binding fragment thereof that binds αvβ3 integrin, as well as methods of use in the treatment of diseases and disorders.. . ... The University Of North Carolina At Chapel Hill

01/11/18 / #20180013639

Methods, systems, and computer readable media for generating and using a web page classification model

Methods, systems, and computer readable media for generating and using a web page classification model are disclosed. The method may include identifying a plurality of web pages for generating a web page classification model, assigning a label to each of the plurality of web pages, accessing transmission control protocol/internet protocol (tcp/ip) traffic traces associated with downloading content from each of the plurality of web pages, processing tcp/ip headers from the tcp/ip traffic traces to identify and extract features that discriminate between the labels, that are uncorrelated and whose discriminatory accuracy remains stable across time and/or browser platform. ... The University Of North Carolina At Chapel Hill

01/11/18 / #20180009908

Igg bispecific antibodies and processes for preparation

The present invention provides fully igg bi-specific antibodies comprising designed residues in the interface of the heavy chain-heavy chain (ch3/ch3) domains, processes for preparing said fully igg bi-specific antibodies, and nucleic acids, vectors and host cells encoding the same.. . ... The University Of North Carolina At Chapel Hill

01/04/18 / #20180002722

Methods and compositions for targeted gene transfer

The present invention provides aav capsid proteins comprising a modification in the amino acid sequence and virus capsids and virus vectors comprising the modified aav capsid protein. The invention also provides methods of administering the virus vectors and virus capsids of the invention to a cell or to a subject in vivo.. ... The University Of North Carolina At Chapel Hill

01/04/18 / #20180002672

Methods to generate gastrointestinal epithelial tissue constructs

A method of making a live cell construct is carried out by: (a) providing a non-cellular support having a top surface and a bottom surface, (b) contacting live undifferentiated cells to the non-cellular support, and then (c) propagating a gastrointestinal epithelial cell monolayer on said top surface. In some embodiments, the live cells in the monolayer include: (i) undifferentiated cells (e.g., stem or progenitor cells); and (ii) optionally, but in some embodiments preferably, differentiated cells (e.g., enterocytes, paneth cells, enteroendocrine cells, tuft cells, microcells, intra-epithelial lymphocytes, and/or goblet cells). ... The University Of North Carolina At Chapel Hill

12/28/17 / #20170369849

Compositions and methods for bioengineered tissues

The present disclosure provides methods for producing bioengineered tissue along with an apparatus and other relevant compositions employed in generation thereof.. . ... The University Of North Carolina At Chapel Hill

12/28/17 / #20170368199

Methods and compositions for treating dystroglycanopathy disorders

The invention relates to synthetic polynucleotides encoding fukutin related protein (fkrp). The invention further relates to nucleic acid constructs comprising the synthetic polynucleotides and methods of using these synthetic polynucleotides to treat dystroglycanopathy disorders.. ... The University Of North Carolina At Chapel Hill

12/21/17 / #20170360960

Aav vectors targeted to the central nervous system

The invention relates to chimeric aav capsids targeted to the central nervous system, virus vectors comprising the same, and methods of using the vectors to target the central nervous system. The invention further relates to chimeric aav capsids targeted to oligodendrocytes, virus vectors comprising the same, and methods of using the vectors to target oligodendrocytes.. ... The University Of North Carolina At Chapel Hill

11/30/17 / #20170345398

Minimal-latency tracking and display for matching real and virtual worlds in head-worn displays

Methods, systems, and computer readable media for minimal-latency tracking and display for matching real and virtual worlds in head-worn displays are disclosed. According to one aspect, a method for minimal-latency tracking and display for matching real and virtual worlds in head-worn displays includes calculating a desired image, calculating an error image as the difference between the desired image and an image currently being perceived by a user, identifying as an error portion a portion of the error image having the largest error, updating a portion of a projected image that corresponds to the error portion, and recalculating the image currently being perceived by a user based on the updated projected image.. ... The University Of North Carolina At Chapel Hill

11/23/17 / #20170333548

Methods and compositions for recombinant dengue viruses for vaccine and diagnostic development

The present invention provides compositions and methods of use comprising a chimeric dengue virus e glycoprotein comprising a dengue virus e glycoprotein backbone, which comprises amino acid substitutions that introduce an epitope that is recognized by an antibody from a dengue virus serotype that is different from the dengue virus serotype of the dengue virus e glycoprotein backbone.. . ... The University Of North Carolina At Chapel Hill

11/23/17 / #20170333347

Metal bisphosphonate nanoparticles for anti-cancer therapy and imaging and for treating bone disorders

Metal-bisphosphonate nanoparticles are disclosed. Also disclosed are pharmaceutical compositions including the metal-bisphosphonate nanoparticles, methods of preparing the metal-bisphosphonate nanoparticles and materials comprising the nanoparticles, and methods of using the compositions to treat cancer or bone-related disorders (e.g., bone-resorption-related diseases, osteoporosis, paget's disease, and bone metastases) and as imaging agents.. ... The University Of North Carolina At Chapel Hill

11/16/17 / #20170329037

Mobile and free-form x-ray imaging systems and methods

A three-dimensional (3d) x-ray tomographic imaging system includes an x-ray source fixedly attached to a first unmanned vehicle, which can be aerial or otherwise configured for locomotion, and an x-ray detector. A vehicle controller is configured to be operated by an operator, and an optical camera is mounted to the first unmanned vehicle at a fixed position relative to the x-ray source, and an optical pattern is fixed at a position relative to the x-ray detector. ... The University Of North Carolina At Chapel Hill

11/09/17 / #20170322180

Pressure driven microfluidic injection for chemical separations

Methods that allow independently applied pressures to a bge reservoir and a sample reservoir for pressure-driven injection that can inject a discrete sample plug into a separation channel that does not require voltage applied to the sample reservoir and can allow for in-channel focusing methods to be used. The methods are particularly suitable for use with a mass spectrometer.. ... The University Of North Carolina At Chapel Hill

10/26/17 / #20170309840

High efficiency dye sensitized photoelectrosynthesis cells

Electrodes useful in dye sensitized photoelectrosynthesis cells provide a coreshell nanoparticle having a chromophore and a catalyst, or a chromophore-catalyst assembly, linked to the shell material. Optionally, an overlayer stabilizes the chromophore or chromophore-catalyst assembly on the shell material. ... The University Of North Carolina At Chapel Hill

10/26/17 / #20170309204

Modular staged reality simulator

This invention is directed to a modular staged simulator and a process of simulating medical trauma and maladies for the purpose of training or certifying individuals including medical professionals. More specifically, this disclosure relates to ex vivo training exercises as opposed to traditional forms of training using intact cadavers, in vivo surgery on animal subjects; and supervised apprenticeship performing surgery on human subjects with trauma or maladies under the watch of a skilled medical practitioner.. ... The University Of North Carolina At Chapel Hill

09/28/17 / #20170274024

Aav vectors targeted to oligodendrocytes

The invention relates to chimeric aav capsids targeted to oligodendrocytes, virus vectors comprising the same, and methods of using the vectors to target oligodendrocytes.. . ... The University Of North Carolina At Chapel Hill

09/21/17 / #20170271139

Mass spectrometry systems with convective flow of buffer gas for enhanced signals and related methods

Mass spectrometry systems include an ionizer, mass analyzer and the detector, with a high pressure chamber holding the mass analyzer and a separate chamber holding the detector to allow for differential background pressures where p2<p1 which generates gas flow through an unsealed, sealed or partially sealed ion trap and enhances detected signal relative to when p2=p1.. . ... The University Of North Carolina At Chapel Hill

09/21/17 / #20170266188

Methods for the treatment of cancer

The invention provides combinations comprising a mertk inhibitor, or a pharmaceutically acceptable salt thereof, and an egfr inhibitor and methods of use thereof, including methods of treating disorders such as cancer.. . ... The University Of North Carolina At Chapel Hill

09/14/17 / #20170263432

Miniature charged particle trap with elongated trapping region for mass spectrometry

A miniature electrode apparatus is disclosed for trapping charged particles, the apparatus including, along a longitudinal direction: a first end cap electrode; a central electrode having an aperture; and a second end cap electrode. The aperture is elongated in the lateral plane and extends through the central electrode along the longitudinal direction and the central electrode surrounds the aperture in a lateral plane perpendicular to the longitudinal direction to define a transverse cavity for trapping charged particles.. ... The University Of North Carolina At Chapel Hill

08/24/17 / #20170244976

Methods, systems, and computer readable media for compressing video images

Methods, systems, and computer readable media for compressing video images are disclosed. According to one exemplary method, the method includes classifying image pixels in each video image of a series of video images as either foreground or background. ... The University Of North Carolina At Chapel Hill

08/24/17 / #20170243522

Radiation-free simulator systems and methods for simulating fluoroscopic or other procedures

Radiation-free simulator systems and methods for simulating fluoroscopic procedures or other medical procedures are provided. Simulator systems, methods and computer readable media are provided, comprising a physical, anatomical model of an anatomy of interest, at least one or more video camera positioned proximate the anatomical model and configured to transmit a live video feed or image of the anatomical model, a computer configured for combining a recorded video feed or 2d rendering of a 3d dataset of an actual anatomical area of interest with the live video feed or image of the anatomical model to form a composite image or video, and a display configured to display the composite image or video. ... The University Of North Carolina At Chapel Hill

08/24/17 / #20170242033

Epithelial cell spheroids and methods of making and using the same

Provided are epithelial cell spheroids including spheroids that have apical membranes and cilia that face towards the interior core of the spheroid and spheroids that have apical membranes and cilia that face away from the interior core of the spheroid. Also provided methods of making and using such spheroids.. ... The University Of North Carolina At Chapel Hill

08/24/17 / #20170238852

Extended analytical performance of continuous glucose monitoring devices via nitric oxide

The present invention relates to instruments and methods related to the in vivo analytical performance of percutaneously implanted nitric oxide (no)-releasing amperometric glucose biosensors. Needle-type glucose biosensors can be functionalized with no-releasing polyurethane coatings designed to release similar total amounts of no for rapid or slower (greater than 3 day) durations and remain functional as outer glucose sensor membranes. ... The University Of North Carolina At Chapel Hill

08/17/17 / #20170233827

Methods and compositions for prognostic and/or diagnostic subtyping of pancreatic cancer

Methods for generating a prognostic and/or subtype signature for a subject with pancreatic ductal adenocarcinoma (pdac) are provided. In some embodiments, the methods include determining expression levels for one or more genes listed in tables 2-5, 9, 10, or 11, and/or the de-s and/or de-t subset of genes in pdac cells obtained from the subject, wherein the determining provides a prognostic and/or subtype signature for the subject. ... The University Of North Carolina At Chapel Hill

08/17/17 / #20170233797

Microfluidic devices, solid supports for reagents and related methods

A microfluidic device includes a plurality of reaction wells; and a plurality of solid supports, and each of the solid supports has a reagent attached thereto. The reagent is attached to the solid support via a labile reagent/support bond such that the reagent is configured to be cleaved from the support via a cleaving operation.. ... The University Of North Carolina At Chapel Hill

08/03/17 / #20170219498

Optical geometry calibration devices, systems, and related methods for three dimensional x-ray imaging

Optical geometry calibration devices, systems, and related methods for x-ray imaging are disclosed. An optical-based geometry calibration device is configured to interface with a two-dimensional (2d) imaging device to perform three-dimensional (3d) imaging. ... The University Of North Carolina At Chapel Hill

07/20/17 / #20170204186

Depletion of plasmacytoid dendritic cells

The present invention relates to antibodies targeted to bdca2 that deplete plasmacytoid dendritic cells (pdc) and methods of using the antibodies to treat disorders associated with pdc.. . ... The University Of North Carolina At Chapel Hill

07/20/17 / #20170202448

Methods, systems, and computer readable media for predicting early onset glaucoma

Methods, systems, and computer readable media for predicting early onset glaucoma via structural parameters obtained via time and spectral-domain optical coherence tomography (sd-oct) are disclosed. Sd-oct technology measures the thicknesses of the layers of the retina that contain the cells that die in glaucoma before there is any functional loss. ... The University Of North Carolina At Chapel Hill

07/06/17 / #20170195678

Methods, systems, and computer readable media for performing image compression

Methods, systems, and computer readable media for performing image compression are disclosed. According to one exemplary method, the method includes identifying a canonical image set from a plurality of images uploaded to or existing on a cloud computing and/or a storage environment. ... The University Of North Carolina At Chapel Hill

07/06/17 / #20170195353

Methods, systems, and computer readable media for detecting malicious network traffic

Methods, systems, and computer readable media for detecting malicious network traffic are disclosed. According to one method, the method includes caching network traffic transmitted between a client and a server, wherein the network traffic includes a uniform resource locator (url) for accessing at least one file from the server. ... The University Of North Carolina At Chapel Hill

06/22/17 / #20170175181

Nanofluidic devices for the rapid mapping of whole genomes and related systems and methods of analysis

Devices and methods generate an ordered restriction map of genomic dna extracted from whole cells. The devices have a fluidic microchannel that merges into a reaction nanochannel that merges into a detection nanochannel at an interface where the nanochannel diameter decreases in size by between 50% to 99%. ... The University Of North Carolina At Chapel Hill

06/22/17 / #20170175088

Methods and compositions for producing vitamin k dependent proteins

The present invention relates to methods and compositions for improving the productivity of recombinant vitamin k dependent protein expression in host cells.. . ... The University Of North Carolina At Chapel Hill

06/22/17 / #20170174768

Depletion of plasmacytoid dendritic cells

The present invention relates to antibodies targeted to bdca2 that deplete plasmacytoid dendritic cells (pdc) and methods of using the antibodies to treat disorders associated with pdc.. . ... The University Of North Carolina At Chapel Hill

06/22/17 / #20170173572

Chiral ligand-based metal-organic frameworks for broad-scope asymmetric catalysis

Metal-organic framework (mofs) compositions based on chiral phosphine-, chiral oxazoline-, chiral pyridine-, and chiral diene-derived organic bridging ligands were synthesized and then post-synthetically metalated with metal precursors such as ru and rh complexes. The metal complexes could also be directly incorporated into the mofs. ... The University Of North Carolina At Chapel Hill

06/15/17 / #20170170001

Microscale mass spectrometry systems, devices and related methods

Mass spectrometry systems or assemblies therefore include an ionizer that includes at least one planar conductor, a mass analyzer with a planar electrode assembly, and a detector comprising at least one planar conductor. The ionizer, the mass analyzer and the detector are attached together in a compact stack assembly. ... The University Of North Carolina At Chapel Hill

06/15/17 / #20170168067

Chromatin-activity-based chemoproteomic (chac) methods and systems for disease marker discovery and development

Methods for identifying and developing biomarkers based on the characterization of disease-related components of gene-specific chromatin regulatory protein complexes. Chemoprobes that are substrate-competitive and selectively bind enzymatically active enzymes associated with gene-specific chromatin regulatory protein complex can be used to select chromatin complexes associated with a phenotype of interest.. ... The University Of North Carolina At Chapel Hill

06/15/17 / #20170166897

Compositions and methods for targeting o-linked n-acetylglucosamine transferase and promoting wound healing

The presently disclosed subject matter provides compounds, compositions, and methods for targeting udp-n-acetylglucosamine polypeptide β-n-acetylglucosaminyl transferase (ogt). Further, the presently disclosed subject matter provides compounds, compositions, and methods for promoting wound healing.. ... The University Of North Carolina At Chapel Hill

06/01/17 / #20170152472

Hepatic stellate cell precursors and methods of isolating same

The present invention relates to precursor cells to hepatic stellate cells, compositions comprising same and methods of isolating same. The surface antigenic profile of the precursors is mhc class ia negative, icam-1+, vcam-1+, β3-integrin+. ... The University Of North Carolina At Chapel Hill

05/18/17 / #20170137803

Methods and compositions for synthetic rna endonucleases

The present invention provides sequence specific restriction enzymes for site-specific cleavage of rna, as well as methods of their use.. . ... The University Of North Carolina At Chapel Hill

05/18/17 / #20170136043

Therapeutic uses of selected pyrrolopyrimidine compounds with anti-mer tyrosine kinase activity

Uses of pyrrolopyrimidines with anti-mer tyrosine kinase activity as anti-infective agents, immunostimulatory and immunomodulatory agents, anti-cancer agents (including against mertk−/− tumors and itd and tkd mutant forms of acute myeloid leukemia (aml)), and as adjunctive agents in combination with chemotherapeutic, radiation or other standard of care for neoplasms.. . ... The University Of North Carolina At Chapel Hill

05/04/17 / #20170126991

Camera sensor with event token based image capture and reconstruction

The subject matter described herein includes a camera sensor with event token based image capture and reconstruction. The sensor includes a photodetector for capturing light from a portion of a scene and for producing a signal indicative of the light. ... The University Of North Carolina At Chapel Hill

04/27/17 / #20170114416

Methods for typing of lung cancer

Methods and compositions are provided for the molecular subtyping of lung cancer samples. Specifically, a method of assessing whether a patient's lung cancer subtype is adenocarcinoma, squamous cell carcinoma, or a neuroendocrine (encompassing both small cell carcinoma and carcinoid) is provided herein. ... The University Of North Carolina At Chapel Hill

04/27/17 / #20170114134

Antagonists of iap-shps1 interaction

Provided herein is technology relating to antagonists that inhibit, reduce, or minimize the interaction of integrin associated protein (iap) with src homology 2 (sh2) domain-containing protein tyrosine phosphatase substrate 1 (shps1) and particularly, but not exclusively, to compositions comprising such antagonists and methods of treatment comprising administering such antagonists.. . ... The University Of North Carolina At Chapel Hill

04/20/17 / #20170110307

Solid phase extraction with capillary electrophoresis

Methods, systems and devices that provide fluid devices with at least one spe bed adjacent (upstream of) a separation channel which may be in communication with an inlet of a mass spectrometer. The fluid device can be configured to operate using independently applied pressures to a bge reservoir and a sample reservoir for pressure-driven injection that can inject a discrete sample plug into a separation channel that does not require voltage applied to the sample reservoir and can allow for in-channel focusing methods to be used. ... The University Of North Carolina At Chapel Hill

04/13/17 / #20170100029

Compositions and methods for analyzing collateral density

The present invention provides a retinal predictor index (rpi), composed of discrete geometric and fractal descriptors of the branch-patterning of the outer retinal circulation, as a biomarker for differences in the extent (number and diameter) of collateral blood vessels in brain, heart, lower extremities and other tissues.. . ... The University Of North Carolina At Chapel Hill

04/06/17 / #20170098535

Electrospray ionization interface to high pressure mass spectrometry and related methods

An electrospray ionization (esi)-mass spectrometer analysis systems include an esi device with at least one emitter configured to electrospray ions and a mass spectrometer in fluid communication with the at least one emitter of the esi device. The mass spectrometer includes a mass analyzer held in a vacuum chamber. ... The University Of North Carolina At Chapel Hill

04/06/17 / #20170096641

Primitive and proximal hepatic stem cells

Hepatic progenitors comprise two populations of human hepatic stem cells, primitive and proximal hepatic stem cells, and two populations of committed progenitors, one for biliary cells and one for hepatocytes. Human primitive hepatic stem cells are a very small fraction of the liver cell population and give rise to proximal hepatic stem cells constituting a much larger fraction of the liver. ... The University Of North Carolina At Chapel Hill

04/06/17 / #20170096455

Methods and compositions for chimeric coronavirus spike proteins

The present invention provides compositions and methods comprising a chimeric coronavirus spike protein.. . ... The University Of North Carolina At Chapel Hill

03/30/17 / #20170088506

Dtpa prodrugs, compositions thereof, and methods of using the same

The present invention relates to trisodium diethylenetriamine pentaacetic acid (dtpa) prodrugs, such as, for example, dtpa di-ethyl esters. The invention further relates to compositions comprising dtpa prodrugs and methods of using the same.. ... The University Of North Carolina At Chapel Hill

03/23/17 / #20170080053

Regulation of sodium channels by plunc proteins

The present invention relates to the ability of plunc proteins, such as splunc1 and splunc2, to bind to sodium channels and inhibit activation of the sodium channels. The invention further relates to methods for regulating of sodium absorption and fluid volume and treating disorders responsive to modulating sodium absorption by modulating the binding of plunc proteins to sodium channels.. ... The University Of North Carolina At Chapel Hill

03/02/17 / #20170057934

Small molecules for inhibiting male fertility

Compounds suitable for use in providing male contraception, an assay method for identifying such compounds, and methods of providing contraception using the compounds, are provided. In one embodiment, the compounds described herein mimic the binding of anti-eppin antibodies to eppin, and thus inhibit the forward motility of sperm in humans and other primates. ... The University Of North Carolina At Chapel Hill

02/02/17 / #20170034641

Methods, systems, and computer readable media for utilizing adaptive rectangular decomposition (ard) to generate head-related transfer functions

Methods, systems, and computer readable media for utilizing adaptive rectangular decomposition (ard) to perform head-related transfer function (hrtf) simulations are disclosed herein. According to one method, the method includes obtaining a mesh model representative of head and ear geometry of a listener entity and segmenting a simulation domain of the mesh model into a plurality of partitions. ... The University Of North Carolina At Chapel Hill

02/02/17 / #20170029453

Bis(phosphine)-carbodicarbene catalyst complexes and methods of using the same

An organometallic complex of a tridentate bis(phosphine)-carbodicarbene ligand and a transition metal, is described. In some embodiments the ligand has the structure of formula (i): the complexes are useful in methods of making an allylic amine carried out by reacting a 1,3-diene with a substituted amine in the presence of such an organometallic complex to produce by intermolecular hydroamination the allylic amine.. ... The University Of North Carolina At Chapel Hill

01/26/17 / #20170025263

Integrated sample processing for electrospray ionization devices

Methods, systems and devices that generate differential axial transport in a fluidic device having at least one fluidic sample separation flow channel and at least one esi emitter in communication with the at least one sample separation flow channel. In response to the generated differential axial transport, the at least one target analyte contained in a sample reservoir in communication with the sample separation channel is selectively transported to the at least one esi emitter while inhibiting transport of contaminant materials contained in the sample reservoir toward the at least one esi emitter thereby preferentially directing analyte molecules out of the at least one esi emitter. ... The University Of North Carolina At Chapel Hill

01/26/17 / #20170021030

Asymmetric bifunctional silyl monomers and particles thereof as prodrugs and delivery vehicles for pharmaceutical, chemical and biological agents

Asymmetric bifunctional silyl (abs) monomers comprising covalently linked pharmaceutical, chemical and biological agents are described. These agents can also be covalently bound via the silyl group to delivery vehicles for delivering the agents to desired targets or areas. ... The University Of North Carolina At Chapel Hill

01/19/17 / #20170015974

Biomatrix scaffolds

The present invention provides biomatrix scaffolds, a tissue extract enriched for extracellular matrix components and bound growth factors, cytokines and hormones, and methods of making and using same.. . ... The University Of North Carolina At Chapel Hill








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