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The University Of North Carolina At Chapel Hill
The University Of North Carolina At Chapel Hill_20131212

The University Of North Carolina At Chapel Hill patents


Recent patent applications related to The University Of North Carolina At Chapel Hill. The University Of North Carolina At Chapel Hill is listed as an Agent/Assignee. Note: The University Of North Carolina At Chapel Hill may have other listings under different names/spellings. We're not affiliated with The University Of North Carolina At Chapel Hill, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "T" | The University Of North Carolina At Chapel Hill-related inventors


Pyrrolopyrimidine compounds for the treatment of cancer

wherein: one of X and X′ is N and the other of X and X′ is C, are described, along with compositions containing the same and methods of use thereof in the treatment of cancer.... The University Of North Carolina At Chapel Hill

Proppant additives for hydraulic fracturing

Hydraulic fracturing of a geological formation is performed by injection of a proppant mixture into the geological formation to form fractures in the geological formation. The proppant mixture includes at least a liquid, proppant, and proppant additive particles. The hydraulic fracturing results in a presence of the proppant additive particles... The University Of North Carolina At Chapel Hill

Methods and compositions for synthetic rna endonucleases

The present invention provides sequence specific restriction enzymes for site-specific cleavage of RNA, as well as methods of their use.... The University Of North Carolina At Chapel Hill

Methods, systems, and computer readable media for image overlap detection

Methods, systems, and computer readable media for image overlap detection. An example method includes identifying, by one or more computers, a collection of images; streaming, by the one or more computers, each image from the collection of images so that, in one or a limited number of passes through the... The University Of North Carolina At Chapel Hill

Activatable crispr/cas9 for spatial and temporal control of genome editing

Disclosed herein is a genetically encoded light- or chemically-activated Cas9 engineered through the site-specific installation of an activatable lysine amino acid. Such activatable Cas9 proteins can be used in CRISPR/Cas9 systems to control gene expression temporally, spatially, or both. Systems, methods, kits, and compositions for manipulation of sequences and/or activities... The University Of North Carolina At Chapel Hill

Delivery vehicles for stem cells and uses thereof

Provided herein according to some embodiments is a biocompatible scaffold comprising stem cells (e.g., a pliable scaffold) suitable for intracavity administration after surgical removal of a tumor, wherein the scaffold allows the stem cells to migrate away from the scaffold and towards a cancerous or damaged tissue, wherein the stem... The University Of North Carolina At Chapel Hill

Polymeric microneedles and rapid additive manufacturing of the same

The invention generally relates to microneedle devices, methods of making same, pharmaceutical compositions comprising same, and methods of treating a disease comprising administering same. Specifically, the disclosed microneedle devices comprise a plurality of biocompatible microneedles having one or more of: (i) a curved, discontinuous, undercut, and/or perforated sidewall; (ii) a... The University Of North Carolina At Chapel Hill

Polymeric metformin and its use as a therapeutic agent and as a delivery vehicle

Provided herein are polymers comprising Metformin residues (“PolyMet”) as useful therapeutic agents, delivery vehicles and transfection agents for nucleotides. Also provided herein are methods for the treatment of a disease or an unwanted condition in a subject, wherein the methods comprise administering PolyMet as a therapeutic agent to combat the... The University Of North Carolina At Chapel Hill

Ephemeral substrates for oyster aquaculture

Provided is novel ephemeral substrate material for growing oysters that alleviates concerns related to adding large quantities of permanent fill to estuarine water and promotes high rates of oyster survival and growth, high meat quality and market-favorable shell-shape of cultured oysters, along with artificial oyster growing structures prepared from the... The University Of North Carolina At Chapel Hill

Methods for making neural stem cells and uses thereof

Provided herein according to some embodiments is a method for producing an induced neural stem cell (iNSC), which method may include one or more of the steps of: providing a somatic cell; introducing into (e.g., by transfecting or transducing) said somatic cell with a nucleic acid encoding Sox2, whereby said... The University Of North Carolina At Chapel Hill

Acoustic imaging with expandable microcapsules

The present disclosure relates generally to expandable microcapsules and their utilization for acoustic imaging within a geological formation. The present disclosure further relates to expandable microcapsules with a multicomponent core and disclosure to practical utilization of multicomponent cores for controlling the expansion properties (e.g., temperature and pressure of expansion, expansion... The University Of North Carolina At Chapel Hill

Monoclonal antibodies for enhancing or inhibiting insulin-like growth factor 1 (igf-1)

The present invention provides an antibody or antigen-binding fragment thereof that binds αvβ3 integrin, as well as methods of use in the treatment of diseases and disorders.... The University Of North Carolina At Chapel Hill

Methods and compositions for unsilencing imprinted genes

The present invention provides methods and compositions for inducing expression of Ube3a in a cell by contacting the cell with a topoisomerase inhibitor. Particular embodiments include a method of treating a genomic imprinting disorder, such as Angelman syndrome, in a subject by administering to the subject an effective amount of... The University Of North Carolina At Chapel Hill

Igg bispecific antibodies and processes for preparation

The present invention provides fully IgG bi-specific antibodies comprising designed residues in the interface of the heavy chain-heavy chain (CH3/CH3) domains, processes for preparing said fully IgG bi-specific antibodies, and nucleic acids, vectors and host cells encoding the same.... The University Of North Carolina At Chapel Hill

Methods, systems, and computer readable media for generating and using a web page classification model

Methods, systems, and computer readable media for generating and using a web page classification model are disclosed. The method may include identifying a plurality of web pages for generating a web page classification model, assigning a label to each of the plurality of web pages, accessing Transmission Control Protocol/Internet Protocol... The University Of North Carolina At Chapel Hill

Apparatuses, systems, and methods for preclinical ultrasound imaging of subjects

Apparatuses, systems, and methods for preclinical ultrasound imaging of subjects are provided. In one aspect, the apparatus can include a platform on which a subject is positionable and at least one motion stage for controlling a spatial position of at least one ultrasound transducer relative to the platform in order... The University Of North Carolina At Chapel Hill

Methods to generate gastrointestinal epithelial tissue constructs

A method of making a live cell construct is carried out by: (a) providing a non-cellular support having a top surface and a bottom surface, (b) contacting live undifferentiated cells to the non-cellular support, and then (c) propagating a gastrointestinal epithelial cell monolayer on said top surface. In some embodiments,... The University Of North Carolina At Chapel Hill

Methods and compositions for targeted gene transfer

The present invention provides AAV capsid proteins comprising a modification in the amino acid sequence and virus capsids and virus vectors comprising the modified AAV capsid protein. The invention also provides methods of administering the virus vectors and virus capsids of the invention to a cell or to a subject... The University Of North Carolina At Chapel Hill

Optimized mini-dystrophin genes and expression cassettes and their use

This invention relates to polynucleotides encoding mini-dystrophin proteins, viral vectors comprising the same, and methods of using the same for delivery of mini-dystrophin to a cell or a subject.... The University Of North Carolina At Chapel Hill

Methods and compositions for treating dystroglycanopathy disorders

The invention relates to synthetic polynucleotides encoding fukutin related protein (FKRP). The invention further relates to nucleic acid constructs comprising the synthetic polynucleotides and methods of using these synthetic polynucleotides to treat dystroglycanopathy disorders.... The University Of North Carolina At Chapel Hill

Compositions and methods for bioengineered tissues

The present disclosure provides methods for producing bioengineered tissue along with an apparatus and other relevant compositions employed in generation thereof.... The University Of North Carolina At Chapel Hill

Compositions and methods for preventing and treating graft versus host disease

ILC2 cells play a role in the pathogenesis of graft versus host disease (GvHD) and idiopathic pneumonia syndrome (IPS), both conditions associated with allogeneic stem cell transplantation. Infusion of IL-33 activated ILC2 cells into patients with ongoing GvHD or IPS, or prior to onset of GvHD or IPS in susceptible... The University Of North Carolina At Chapel Hill

Aav vectors targeted to the central nervous system

The invention relates to chimeric AAV capsids targeted to the central nervous system, virus vectors comprising the same, and methods of using the vectors to target the central nervous system. The invention further relates to chimeric AAV capsids targeted to oligodendrocytes, virus vectors comprising the same, and methods of using... The University Of North Carolina At Chapel Hill

Minimal-latency tracking and display for matching real and virtual worlds in head-worn displays

Methods, systems, and computer readable media for minimal-latency tracking and display for matching real and virtual worlds in head-worn displays are disclosed. According to one aspect, a method for minimal-latency tracking and display for matching real and virtual worlds in head-worn displays includes calculating a desired image, calculating an error... The University Of North Carolina At Chapel Hill

Metal bisphosphonate nanoparticles for anti-cancer therapy and imaging and for treating bone disorders

Metal-bisphosphonate nanoparticles are disclosed. Also disclosed are pharmaceutical compositions including the metal-bisphosphonate nanoparticles, methods of preparing the metal-bisphosphonate nanoparticles and materials comprising the nanoparticles, and methods of using the compositions to treat cancer or bone-related disorders (e.g., bone-resorption-related diseases, osteoporosis, Paget's disease, and bone metastases) and as imaging agents.... The University Of North Carolina At Chapel Hill

Methods and compositions for recombinant dengue viruses for vaccine and diagnostic development

The present invention provides compositions and methods of use comprising a chimeric dengue virus E glycoprotein comprising a dengue virus E glycoprotein backbone, which comprises amino acid substitutions that introduce an epitope that is recognized by an antibody from a dengue virus serotype that is different from the dengue virus... The University Of North Carolina At Chapel Hill

Peptide inhibitors of sodium channels

The present invention relates to the ability of specialized non-naturally occurring peptides to bind to sodium channels and inhibit activation of the sodium channels. The invention further relates to methods for regulating of sodium absorption and fluid volume and treating disorders responsive to modulating sodium absorption by modulating the binding... The University Of North Carolina At Chapel Hill

Mobile and free-form x-ray imaging systems and methods

A three-dimensional (3D) x-ray tomographic imaging system includes an x-ray source fixedly attached to a first unmanned vehicle, which can be aerial or otherwise configured for locomotion, and an x-ray detector. A vehicle controller is configured to be operated by an operator, and an optical camera is mounted to the... The University Of North Carolina At Chapel Hill

Pressure driven microfluidic injection for chemical separations

Methods that allow independently applied pressures to a BGE reservoir and a sample reservoir for pressure-driven injection that can inject a discrete sample plug into a separation channel that does not require voltage applied to the sample reservoir and can allow for in-channel focusing methods to be used. The methods... The University Of North Carolina At Chapel Hill

Modular staged reality simulator

This invention is directed to a modular staged simulator and a process of simulating medical trauma and maladies for the purpose of training or certifying individuals including medical professionals. More specifically, this disclosure relates to ex vivo training exercises as opposed to traditional forms of training using intact cadavers, in... The University Of North Carolina At Chapel Hill

High efficiency dye sensitized photoelectrosynthesis cells

Electrodes useful in dye sensitized photoelectrosynthesis cells provide a coreshell nanoparticle having a chromophore and a catalyst, or a chromophore-catalyst assembly, linked to the shell material. Optionally, an overlayer stabilizes the chromophore or chromophore-catalyst assembly on the shell material. In some embodiments, the core material comprises tin oxide; the shell... The University Of North Carolina At Chapel Hill

Molecular diagnosis and typing of lung cancer variants

Compositions and methods useful in determining the major morphological types of lung cancer are provided. The methods include detecting expression of at least one gene or biomarker in a sample. The expression of the gene or biomarker is indicative of the lung tumor subtype. The compositions include subsets of genes... The University Of North Carolina At Chapel Hill

Solid phase extraction with capillary electrophoresis

Methods, systems and devices that provide fluid devices with at least one SPE bed adjacent (upstream of) a separation channel which may be in communication with an inlet of a Mass Spectrometer. The fluid device can be configured to operate using independently applied pressures to a BGE reservoir and a... The University Of North Carolina At Chapel Hill

Aav vectors targeted to oligodendrocytes

The invention relates to chimeric AAV capsids targeted to oligodendrocytes, virus vectors comprising the same, and methods of using the vectors to target oligodendrocytes.... The University Of North Carolina At Chapel Hill

Methods for the treatment of cancer

The invention provides combinations comprising a MERTK inhibitor, or a pharmaceutically acceptable salt thereof, and an EGFR inhibitor and methods of use thereof, including methods of treating disorders such as cancer.... The University Of North Carolina At Chapel Hill

09/21/17 / #20170271139

Mass spectrometry systems with convective flow of buffer gas for enhanced signals and related methods

Mass spectrometry systems include an ionizer, mass analyzer and the detector, with a high pressure chamber holding the mass analyzer and a separate chamber holding the detector to allow for differential background pressures where P2<P1 which generates gas flow through an unsealed, sealed or partially sealed ion trap and enhances... The University Of North Carolina At Chapel Hill

09/14/17 / #20170263432

Miniature charged particle trap with elongated trapping region for mass spectrometry

A miniature electrode apparatus is disclosed for trapping charged particles, the apparatus including, along a longitudinal direction: a first end cap electrode; a central electrode having an aperture; and a second end cap electrode. The aperture is elongated in the lateral plane and extends through the central electrode along the... The University Of North Carolina At Chapel Hill

08/24/17 / #20170238852

Extended analytical performance of continuous glucose monitoring devices via nitric oxide

The present invention relates to instruments and methods related to the in vivo analytical performance of percutaneously implanted nitric oxide (NO)-releasing amperometric glucose biosensors. Needle-type glucose biosensors can be functionalized with NO-releasing polyurethane coatings designed to release similar total amounts of NO for rapid or slower (greater than 3 day)... The University Of North Carolina At Chapel Hill

08/24/17 / #20170242033

Epithelial cell spheroids and methods of making and using the same

Provided are epithelial cell spheroids including spheroids that have apical membranes and cilia that face towards the interior core of the spheroid and spheroids that have apical membranes and cilia that face away from the interior core of the spheroid. Also provided methods of making and using such spheroids.... The University Of North Carolina At Chapel Hill

08/24/17 / #20170243522

Radiation-free simulator simulating fluoroscopic or other procedures

Radiation-free simulator systems and methods for simulating fluoroscopic procedures or other medical procedures are provided. Simulator systems, methods and computer readable media are provided, comprising a physical, anatomical model of an anatomy of interest, at least one or more video camera positioned proximate the anatomical model and configured to transmit... The University Of North Carolina At Chapel Hill

08/24/17 / #20170244976

Methods, systems, and computer readable media for compressing video images

Methods, systems, and computer readable media for compressing video images are disclosed. According to one exemplary method, the method includes classifying image pixels in each video image of a series of video images as either foreground or background. The method also includes replacing each pixel classified as background with a... The University Of North Carolina At Chapel Hill

08/17/17 / #20170233797

Microfluidic devices, solid supports for reagents and related methods

A microfluidic device includes a plurality of reaction wells; and a plurality of solid supports, and each of the solid supports has a reagent attached thereto. The reagent is attached to the solid support via a labile reagent/support bond such that the reagent is configured to be cleaved from the... The University Of North Carolina At Chapel Hill

08/17/17 / #20170233827

Methods and compositions for prognostic and/or diagnostic subtyping of pancreatic cancer

Methods for generating a prognostic and/or subtype signature for a subject with pancreatic ductal adenocarcinoma (PDAC) are provided. In some embodiments, the methods include determining expression levels for one or more genes listed in Tables 2-5, 9, 10, or 11, and/or the DE-S and/or DE-T subset of genes in PDAC... The University Of North Carolina At Chapel Hill

08/10/17 / #20170226180

Peptide inhibitors of sodium channels

The present invention relates to the ability of specialized non-naturally occurring peptides to bind to sodium channels and inhibit activation of the sodium channels. The invention further relates to methods for regulating of sodium absorption and fluid volume and treating disorders responsive to modulating sodium absorption by modulating the binding... The University Of North Carolina At Chapel Hill

08/03/17 / #20170219498

Optical geometry calibration devices, systems, and related methods for three dimensional x-ray imaging

Optical geometry calibration devices, systems, and related methods for x-ray imaging are disclosed. An optical-based geometry calibration device is configured to interface with a two-dimensional (2D) imaging device to perform three-dimensional (3D) imaging. The optical-based geometry calibration device includes one or more optical cameras fixed to either an x-ray source... The University Of North Carolina At Chapel Hill

07/27/17 / #20170213039

Methods, systems, and computer readable media for preventing code reuse attacks

Methods, systems, and computer readable media for preventing code reuse attacks are disclosed. According to one method, the method includes executing, on a processor, code in a memory page related to an application, wherein the memory page is protected. The method also includes detecting a read request associated with the... The University Of North Carolina At Chapel Hill

07/20/17 / #20170202448

Methods, systems, and computer readable media for predicting early onset glaucoma

Methods, systems, and computer readable media for predicting early onset glaucoma via structural parameters obtained via time and spectral-domain optical coherence tomography (SD-OCT) are disclosed. SD-OCT technology measures the thicknesses of the layers of the retina that contain the cells that die in glaucoma before there is any functional loss.... The University Of North Carolina At Chapel Hill

07/20/17 / #20170202847

Methods for the treatment of tumors

The present invention is directed to methods of treating a tumor, in particular human tumors, including administering an effective amount of a MER tyrosine kinase inhibitor (MER TKI) to inhibit TKI signaling in a tumor. The use of a MER TKI in combination with a chemotherapeutic agent, wherein the MER... The University Of North Carolina At Chapel Hill

07/20/17 / #20170204186

Depletion of plasmacytoid dendritic cells

The present invention relates to antibodies targeted to BDCA2 that deplete plasmacytoid dendritic cells (pDC) and methods of using the antibodies to treat disorders associated with pDC.... The University Of North Carolina At Chapel Hill

07/06/17 / #20170195353

Methods, systems, and computer readable media for detecting malicious network traffic

Methods, systems, and computer readable media for detecting malicious network traffic are disclosed. According to one method, the method includes caching network traffic transmitted between a client and a server, wherein the network traffic includes a uniform resource locator (URL) for accessing at least one file from the server. The... The University Of North Carolina At Chapel Hill

07/06/17 / #20170195678

Methods, systems, and computer readable media for performing image compression

Methods, systems, and computer readable media for performing image compression are disclosed. According to one exemplary method, the method includes identifying a canonical image set from a plurality of images uploaded to or existing on a cloud computing and/or a storage environment. The method also includes computing an image representation... The University Of North Carolina At Chapel Hill

06/22/17 / #20170173572

Chiral ligand-based metal-organic frameworks for broad-scope asymmetric catalysis

Metal-organic framework (MOFs) compositions based on chiral phosphine-, chiral oxazoline-, chiral pyridine-, and chiral diene-derived organic bridging ligands were synthesized and then post-synthetically metalated with metal precursors such as Ru and Rh complexes. The metal complexes could also be directly incorporated into the MOFs. The MOFs provide a versatile family... The University Of North Carolina At Chapel Hill

06/22/17 / #20170174768

Depletion of plasmacytoid dendritic cells

The present invention relates to antibodies targeted to BDCA2 that deplete plasmacytoid dendritic cells (pDC) and methods of using the antibodies to treat disorders associated with pDC.... The University Of North Carolina At Chapel Hill

06/22/17 / #20170175088

Methods and compositions for producing vitamin k dependent proteins

The present invention relates to methods and compositions for improving the productivity of recombinant vitamin K dependent protein expression in host cells.... The University Of North Carolina At Chapel Hill

06/22/17 / #20170175181

Nanofluidic devices for the rapid mapping of whole genomes and related systems and methods of analysis

Devices and methods generate an ordered restriction map of genomic DNA extracted from whole cells. The devices have a fluidic microchannel that merges into a reaction nanochannel that merges into a detection nanochannel at an interface where the nanochannel diameter decreases in size by between 50% to 99%. Intact molecules... The University Of North Carolina At Chapel Hill

06/15/17 / #20170168067

Chromatin-activity-based chemoproteomic (chac) methods and systems for disease marker discovery and development

Methods for identifying and developing biomarkers based on the characterization of disease-related components of gene-specific chromatin regulatory protein complexes. Chemoprobes that are substrate-competitive and selectively bind enzymatically active enzymes associated with gene-specific chromatin regulatory protein complex can be used to select chromatin complexes associated with a phenotype of interest.... The University Of North Carolina At Chapel Hill

06/15/17 / #20170170001

Microscale mass spectrometry systems, devices and related methods

Mass spectrometry systems or assemblies therefore include an ionizer that includes at least one planar conductor, a mass analyzer with a planar electrode assembly, and a detector comprising at least one planar conductor. The ionizer, the mass analyzer and the detector are attached together in a compact stack assembly. The... The University Of North Carolina At Chapel Hill

06/08/17 / #20170157127

Methods of facilitating cell survival using neurotrophin mimetics

Methods and compounds for treating neurodegenerative and other disorders. Included is the administering to a subject in need thereof an effective amount of a compound having binding specificity for a p75NTR receptor molecule. Enhanced survival of neural and other cells has been observed.... The University Of North Carolina At Chapel Hill

05/25/17 / #20170146381

Devices, systems, and methods for volumetrically measuring syringe fluid

Devices, systems, and methods for volumetrically measuring syringe fluid are disclosed. In one aspect, a device for volumetrically measuring syringe fluid includes a reference plate, a flange adapter base attached at a first end of the reference plate for receiving a flange of a syringe, a plunger adapter disposed adjacent... The University Of North Carolina At Chapel Hill

05/18/17 / #20170136043

Therapeutic uses of selected pyrrolopyrimidine compounds with anti-mer tyrosine kinase activity

Uses of pyrrolopyrimidines with anti-Mer tyrosine kinase activity as anti-infective agents, immunostimulatory and immunomodulatory agents, anti-cancer agents (including against MerTK−/− tumors and ITD and TKD mutant forms of Acute Myeloid Leukemia (AML)), and as adjunctive agents in combination with chemotherapeutic, radiation or other standard of care for neoplasms.... The University Of North Carolina At Chapel Hill

05/18/17 / #20170137803

Methods and compositions for synthetic rna endonucleases

The present invention provides sequence specific restriction enzymes for site-specific cleavage of RNA, as well as methods of their use.... The University Of North Carolina At Chapel Hill

05/18/17 / #20170141430

Hybrid solid single-ion-conducting electrolytes for alkali batteries

Solid electrolyte compositions are described. The solid electrolyte compositions may include a composite including an inorganic solid electrolyte and an ion conducting fluoropolymer. A cation transference number of each of the inorganic solid electrolyte and the ion conducting fluoropolymer may be at least 0.9. The inorganic solid electrolyte may be... The University Of North Carolina At Chapel Hill

05/11/17 / #20170130222

Small molecules that enhance the activity of oligonucleotides

Methods of administering an oligonucleotide of interest into a cell in vitro or in vivo are described. In the methods, a small organic compound active agent is concurrently administered to the cell in an amount effective to increase the delivery of the oligonucleotide into the cell, and/or increase the activity... The University Of North Carolina At Chapel Hill

05/04/17 / #20170119895

Combination therapy comprising a liposomal prodrug of mitomycin c and radiotherapy

A method of treating neoplasia in a subject in need of treatment is provided by administering to the subject an amount of a prodrug of mitomycin C that yields a therapeutically effective amount of mitomycin C, in combination with radiation therapy. In one embodiment, the prodrug of mitomycin C is... The University Of North Carolina At Chapel Hill

05/04/17 / #20170126991

Camera sensor with event token based image capture and reconstruction

The subject matter described herein includes a camera sensor with event token based image capture and reconstruction. The sensor includes a photodetector for capturing light from a portion of a scene and for producing a signal indicative of the light. An integrator is coupled to the photodetector for accumulating charge... The University Of North Carolina At Chapel Hill

Patent Packs
04/27/17 / #20170114134

Antagonists of iap-shps1 interaction

Provided herein is technology relating to antagonists that inhibit, reduce, or minimize the interaction of integrin associated protein (IAP) with Src homology 2 (SH2) domain-containing protein tyrosine phosphatase substrate 1 (SHPS1) and particularly, but not exclusively, to compositions comprising such antagonists and methods of treatment comprising administering such antagonists.... The University Of North Carolina At Chapel Hill

04/27/17 / #20170114416

Methods for typing of lung cancer

Methods and compositions are provided for the molecular subtyping of lung cancer samples. Specifically, a method of assessing whether a patient's lung cancer subtype is adenocarcinoma, squamous cell carcinoma, or a neuroendocrine (encompassing both small cell carcinoma and carcinoid) is provided herein. A method for assessing whether a patient's lung... The University Of North Carolina At Chapel Hill

04/20/17 / #20170110307

Solid phase extraction with capillary electrophoresis

Methods, systems and devices that provide fluid devices with at least one SPE bed adjacent (upstream of) a separation channel which may be in communication with an inlet of a Mass Spectrometer. The fluid device can be configured to operate using independently applied pressures to a BGE reservoir and a... The University Of North Carolina At Chapel Hill

04/13/17 / #20170100029

Compositions and methods for analyzing collateral density

The present invention provides a retinal predictor index (RPI), composed of discrete geometric and fractal descriptors of the branch-patterning of the outer retinal circulation, as a biomarker for differences in the extent (number and diameter) of collateral blood vessels in brain, heart, lower extremities and other tissues.... The University Of North Carolina At Chapel Hill

04/06/17 / #20170096455

Methods and compositions for chimeric coronavirus spike proteins

The present invention provides compositions and methods comprising a chimeric coronavirus spike protein.... The University Of North Carolina At Chapel Hill

04/06/17 / #20170098535

Electrospray ionization interface to high pressure mass spectrometry and related methods

An electrospray ionization (ESI)-mass spectrometer analysis systems include an ESI device with at least one emitter configured to electrospray ions and a mass spectrometer in fluid communication with the at least one emitter of the ESI device. The mass spectrometer includes a mass analyzer held in a vacuum chamber. The... The University Of North Carolina At Chapel Hill

03/30/17 / #20170088506

Dtpa prodrugs, compositions thereof, and methods of using the same

The present invention relates to trisodium diethylenetriamine pentaacetic acid (DTPA) prodrugs, such as, for example, DTPA di-ethyl esters. The invention further relates to compositions comprising DTPA prodrugs and methods of using the same.... The University Of North Carolina At Chapel Hill

03/30/17 / #20170089923

Bcl6 expression in eutopic endometrium as a marker for endometriosis and subfertility

Methods for identifying subjects as candidates for embryo implantation are provided. In some embodiments, the methods include providing a sample of endometrium isolated from a subject during the second half of the subject's menstrual cycle and determining whether the subject is a candidate based on the expression of BCL6 in... The University Of North Carolina At Chapel Hill

03/23/17 / #20170080053

Regulation of sodium channels by plunc proteins

The present invention relates to the ability of PLUNC proteins, such as SPLUNC1 and SPLUNC2, to bind to sodium channels and inhibit activation of the sodium channels. The invention further relates to methods for regulating of sodium absorption and fluid volume and treating disorders responsive to modulating sodium absorption by... The University Of North Carolina At Chapel Hill

03/02/17 / #20170057934

Small molecules for inhibiting male fertility

Compounds suitable for use in providing male contraception, an assay method for identifying such compounds, and methods of providing contraception using the compounds, are provided. In one embodiment, the compounds described herein mimic the binding of anti-EPPIN antibodies to EPPIN, and thus inhibit the forward motility of sperm in humans... The University Of North Carolina At Chapel Hill

02/16/17 / #20170044618

Methods and compositions involving intrinsic genes

Disclosed are compositions and methods related intrinsic gene sets and methods and compositions related to detecting and classifying cancer.... The University Of North Carolina At Chapel Hill

02/02/17 / #20170029453

Bis(phosphine)-carbodicarbene catalyst complexes and methods of using the same

An organometallic complex of a tridentate bis(phosphine)-carbodicarbene ligand and a transition metal, is described. In some embodiments the ligand has the structure of Formula (I): The complexes are useful in methods of making an allylic amine carried out by reacting a 1,3-diene with a substituted amine in the presence of... The University Of North Carolina At Chapel Hill

02/02/17 / #20170034641

Methods, systems, and computer readable media for utilizing adaptive rectangular decomposition (ard) to generate head-related transfer functions

Methods, systems, and computer readable media for utilizing adaptive rectangular decomposition (ARD) to perform head-related transfer function (HRTF) simulations are disclosed herein. According to one method, the method includes obtaining a mesh model representative of head and ear geometry of a listener entity and segmenting a simulation domain of the... The University Of North Carolina At Chapel Hill

01/26/17 / #20170021030

Asymmetric bifunctional silyl monomers and particles thereof as prodrugs and delivery vehicles for pharmaceutical, chemical and biological agents

Asymmetric bifunctional silyl (ABS) monomers comprising covalently linked pharmaceutical, chemical and biological agents are described. These agents can also be covalently bound via the silyl group to delivery vehicles for delivering the agents to desired targets or areas. Also described are delivery vehicles which contain ABS monomers comprising covalently linked... The University Of North Carolina At Chapel Hill

01/26/17 / #20170025263

Integrated sample processing for electrospray ionization devices

Methods, systems and devices that generate differential axial transport in a fluidic device having at least one fluidic sample separation flow channel and at least one ESI emitter in communication with the at least one sample separation flow channel. In response to the generated differential axial transport, the at least... The University Of North Carolina At Chapel Hill

Patent Packs
01/19/17 / #20170015974

Biomatrix scaffolds

The present invention provides biomatrix scaffolds, a tissue extract enriched for extracellular matrix components and bound growth factors, cytokines and hormones, and methods of making and using same.... The University Of North Carolina At Chapel Hill








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