The University Of Western Ontario patents

Method and system for registering ultrasound and computed tomography images

A method for registering ultrasound (US) and computed tomography (CT) images, comprising: receiving US and CT images representative of a body portion comprising blood vessels and an initial approximate transform; enhancing the blood vessels in the US and CT images, thereby obtaining an enhanced US and CT images; creating a... The University Of Western Ontario

Self-locking braking system and method

A self-locking brake mechanism, which utilises a cantilever to engage a brake drum to prevent the brake drum from rotating, thereby resulting in braking behaviour. Further, locking mechanisms are provided that are useful for applications involving multiple brakes. The locking mechanism, through suitable use of indexing via Geneva mechanisms, allows... The University Of Western Ontario

3d ultrasound image stitching

A computer-implemented method for combining two 3-dimensional ultrasound images of a patient's body part containing blood vessels into a single 3-dimensional ultrasound image of that body part with a greater field of view. Blood vessels within the body part are used for registration. The two ultrasound images are preprocessed using... The University Of Western Ontario

A counterbalancing gimbal joints and/or a counterbalancing a load on a gimbal joint

Disclosed is a counterbalance apparatus, and a method for counterbalancing using an apparatus, having a center of motion that is internal or external to the apparatus. The apparatus and method are adapted to support a payload, having a load vector applied in a direction of the vector or gravity, that... The University Of Western Ontario

A counterbalance apparatus and/or supporting a load

A counterbalance apparatus for supporting a load includes a base, a load bearing arm, a toggle linkage, and first and second resilient members for applying a force to the load bearing arm. The load bearing arm has pivot points forming a parallelogram linkage, and is adapted to support the load... The University Of Western Ontario

Navigation by bending forces

The present disclosure provides a navigation method and system which does not require a remotely located tracking system, or additional targets or other devices to be installed on the patient or object being tracked. The system uses one flexible component in physical contact with the patient/object and measures relative position... The University Of Western Ontario

Reactor and multifunctional riser and downer simulator incorporating the same

A reactor comprises a reactor vessel defining a confined reactor volume, a support assembly extending about a periphery of the confined reactor volume, a basket positioned within the reactor vessel and supported by the support assembly, the basket having an interior surface and an exterior surface, a downflow zone being... The University Of Western Ontario

Statherin peptides

A novel statherin-based fusion peptide is provided. The fusion peptide comprises the statherin peptide, DSSEEKFLR, or a functionally equivalent variant thereof, fused to an acquired enamel pellicle protein or peptide. The statherin-based fusion peptide is useful to treat dental demineralization. Also provided is hydrogel-encapsulated enamel-protective protein or peptides such as... The University Of Western Ontario

Polymer-drug conjugate based on a polyisoolefin-based copolymer

A polymer-drug conjugate, which can be used in medical applications such as stents, has at least one active agent conjugated through a carboxylic acid moiety to a copolymer derived from at least one isoolefin monomer and at least one copolymerizable monomer, where the copolymerizable monomer is at least one multiolefin... The University Of Western Ontario

Mammalian head cooling system and method

Described herein is a head cooling system comprising: a source of compressed breathable gas; a vortex tube comprising an inlet, a hot gas outlet and a cold gas outlet, the inlet operably connected to the source of compressed breathable gas; and an interface for delivering cooled gas to a nasopharyngeal... The University Of Western Ontario

Oral appliance for administration of electrical stimulation and the use thereof

An oral appliance for use with a subject in his/her mouth includes a flexible tube having an input end and an output end and an electrode coupled to the flexible tube adjacent the output end. The flexible tube is adapted to be positioned in the subject's oral cavity with the... The University Of Western Ontario

Vesicular stomatitis virus for prime boost vaccine

The present invention relates to vesicular stomatitis virus (VSV) matrix (M) protein mutants. One mutant M protein includes a glycine changed to a glutamic acid at position 21, a leucine changed to a phenylalanine at position 111 and a methionine changed to an arginine at position 51. Another M protein... The University Of Western Ontario

Vesicular stomatitis virus for prime boost vaccine

The present invention relates to vesicular stomatitis virus (VSV) matrix (M) protein mutants. One mutant M protein includes a glycine changed to a glutamic acid at position 21, a leucine changed to a phenylalanine at position 111 and a methionine changed to an arginine at position 51. Another M protein... The University Of Western Ontario

System and processing images

A method of processing a plurality of time separated images comprises selecting a plurality of imaging units in each image; measuring a temporal difference in each imaging unit; and selecting temporal differences above a threshold limit.... The University Of Western Ontario

Sonicated biological hydrogen reactor

A method and system for hydrogen production from organic material such as waste. The system includes a bioreactor for continuous anerobic fermentation to produce hydrogen in which a mixture containing a microorganism and organic material is sonicated. The system optionally includes a biomethanator connected in-line with the bioreactor.... The University Of Western Ontario

Polyglyoxylates, manufacture and use thereof

Self-immolative polymers degrade by an end-to-end depolymerization mechanism in response to the cleavage of a stabilizing end-cap from the polymer terminus. Examples include homopolymers, mixed polymers including block copolymers, suitable for a variety of applications. A polyglyoxylate can be end-capped or capped with a linker as in a block copolymer.... The University Of Western Ontario

Vesicular stomatitis virus for prime boost vaccine

The present invention relates to vesicular stomatitis virus (VSV) matrix (M) protein mutants. One mutant M protein includes a glycine changed to a glutamic acid at position 21, a leucine changed to a phenylalanine at position 111 and a methionine changed to an arginine at position 51. Another M protein... The University Of Western Ontario

Oral mouthpiece and the use thereof

The present invention relates generally to an oral device, or mouthpiece, for delivering a fluid to the mouth or oropharynx of a user. In one embodiment, the oral device includes an intraoral portion, an extraoral portion, and an auxiliary support device that serves to stabilize the oral device. In various... The University Of Western Ontario