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The Washington University patents


Recent patent applications related to The Washington University. The Washington University is listed as an Agent/Assignee. Note: The Washington University may have other listings under different names/spellings. We're not affiliated with The Washington University, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "T" | The Washington University-related inventors


Blood biomarkers for appendicitis and diagnostics methods using biomarkers

The invention relates to methods and kits for diagnosing and/or treating appendicitis in a subject, comprising obtaining a biological sample from said subject; detecting rna expression levels of at least three or more biomarkers in the biological sample and comparing the expression levels of said at least three or more biomarkers to a control sample wherein an increase or decrease in the level of expression of said at least three or more biomarkers as compared to the control sample is indicative of appendicitis.. . ... The Washington University

Method of treating low blood pressure

A method for treating a patient suffering from one of septic shock, acute kidney injury, severe hypotension, cardiac arrest, and refractory hypotension, but not from myocardial infarction, is provided. The method includes administering a therapeutically effective dose of angiotensin ii, or ang ii, to the patient.. ... The Washington University

Dry coupling apparatus for photoacoustic computed tomography systems

An apparatus for holding an imaging subject, such as a whole animal, within a photoacoustic computed tomography system with dry acoustic coupling is disclosed. The apparatus includes a dry acoustic coupler with a tubular elastic membrane made of an optically and acoustically transmissive material. ... The Washington University

Camera calibration with lenticular arrays

The present disclosure is directed to an approach to solve camera calibration from a single picture of a simply structured light field created by viewing a carefully designed lenticular sheet. The lenticular sheet has different colors visible at different relative orientations and gives linear constraints on the k-1?r matrix which can be decomposed to give the rotation and calibration. ... The Washington University

Methods of diagnosing and treating cancer comprising me1

The present disclosure provides a method of determining treatment for cancer comprising identifying the absence of malic enzyme 1 (me1) and treating with an inducer of ferroptosis.. . ... The Washington University

3d-printed scaffold device for cell transplantation

Disclosed herein is a 3d-printed, biocompatible macroporous device that houses stem cell derived β-cell (sc-β cell) clusters within a degradable fibrin gel. Cluster sizes are used that avoid severe hypoxia within 3d-printed devices and a microwell-based technique is used for resizing clusters within this range. ... The Washington University

Systems and methods for measuring cardiac strain

A method for rapid computation of three-dimensional displacement and lagrange strain in a high resolution filed of phase data obtained with displacement encoding with stimulated echoes (dense) in magnetic resonance images of the myocardium. The method includes semi-automated segmentation of a region of a heart, phase unwrapping the images in three dimensions, and a custom radial point interpolation method (rpim). ... The Washington University

Opto-mechanical system and method having chaos induced stochastic resonance and opto-mechanically mediated chaos transfer

An a system and method for chaos transfer between multiple detuned signals in a resonator mediated by chaotic mechanical oscillation induced stochastic resonance where at least one signal is strong and where at least one signal is weak and where the strong and weak signal follow the same route, from periodic oscillations to quasi-periodic and finally to chaotic oscillations, as the strong signal power is increased.. . ... The Washington University

Device with multiple microenvironments and methods thereof

Among the various aspects of the present disclosure is the provision of a device with multiple microenvironments and methods of use and manufacture thereof. An aspect of the present disclosure provides for a device for evaluating cell invasion. ... The Washington University

Methods to detect motor neuron disease comprising micro-rnas

The present invention relates to compositions and methods for detecting motor neuron-specific mirnas in a population of cells or subject. More particularly, the invention relates to detecting motor neuron-specific mirnas to detect and treat motor neuron diseases associated with dysregulation of motor neuron-specific mirnas, such as amyotrophic lateral sclerosis (als).. ... The Washington University

Ultrasound-enhanced drug delivery for treatment of onychomycosis

A method of treating onychomycosis is provided. The method includes the steps of submerging a nail infected with onychomycosis in a solution containing at least one pharmaceutical agent, and applying ultrasound to the infected nail. ... The Washington University

Systems and methods for embedded sensors with variance-based logic

A variance-based substrate computing system is disclosed. The variance-based computing system includes a sensor configured to be embedded in a structure, the sensor further configured to generate an electrical output signal in response to a mechanical input, and a processor configured to receive the electrical output signal. ... The Washington University

Peptide regulators of mitochondrial fusion and methods of use

Mitofusin modulatory peptides are described which may function as activators or inhibitors of mitochondrial fusion. The sequences and compositions comprising the sequences are useful for treating diseases or disorders associated with mitofusin 1 (mfn1) and/or mitofusin 2 (mfn2) and mitochondrial dysfunction. ... The Washington University

Background traffic management

A traffic management mechanism can employ a two-tiered approach for managing background traffic based on prioritizing tasks by remaining time flexibility then scheduling prioritized tasks using linear programming.. . ... The Washington University

03/08/18 / #20180066015

Inhibitors of growth factor activation enzymes

The present invention generally relates to compounds that are useful for inhibiting one or more of hepatocyte growth factor activator, matriptase, hepsin, factor xa, or thrombin. The present invention also relates to various methods of using the inhibitor compounds including treating a malignancy, a pre-malignant condition, or cancer by administering an effective amount of the inhibitor to a subject in need thereof.. ... The Washington University

03/08/18 / #20180064932

System for stimulating bone growth, tissue healing and/or pain control, and method of use

A system to deliver current to an area of interest of a subject is described that includes a power source, a controller electrically coupled to the power source, at least one first electrode electrically coupled to the controller, and at least one second electrode electrically coupled to one of the power source and the controller, with the area of interest positioned between the at least one first electrode and the at least one second electrode. A method of stimulating at least one of bone growth, tissue healing and pain control within an area of interest of a patient is described that includes inserting first and second electrode spaced at a predetermined distance, and further includes directing an electric current between the first and second electrodes so that at least a portion of the electric current passes through the area of interest positioned between the first electrode and the second electrode.. ... The Washington University

03/01/18 / #20180057882

Blood rna biomarkers of coronary artery disease

The present invention discloses a unique panel of gene transcripts down-regulated in patients with coronary artery disease (cad). Methods and compositions for detecting cad in patient blood samples are provided.. ... The Washington University

03/01/18 / #20180055923

Compositions and methods for the treatment and prevention of ebp pilus-related diseases

The present invention relates to compositions comprising ebpa and methods of use thereof. Specifically, methods useful in the treatment and prevention of ebpa-associated infections.. ... The Washington University

03/01/18 / #20180055408

Quantitative differentiation of inflammation from solid tumors, heart and nerve injury

D-histo, a non-invasive diagnostic method, renovated from diffusion basis spectrum imaging (dbsi) is provided for quantitatively detecting and distinguishing inflammation from solid tumors, heart and nerve injury. For example, the d-histo methods disclosed herein provide an accurate diagnosis of prostate cancer, distinguishing it from prostatitis and bph that missed by currently available methods of diagnosing prostate cancer (multiparameter mri, needle biopsy). ... The Washington University

02/22/18 / #20180051301

Induction of pacemaker-like cells from cardiomyocytes

Disclosed are compositions and methods relating to the cardiac conduction system. Compositions, methods for converting cardiac tissue to an induced-sinoatrial node, and methods for treating sinus node dysfunction (snd) in an individual in need thereof are disclosed. ... The Washington University

02/22/18 / #20180050054

Administration of nicotinamide mononucleotide in the treatment of disease

Disclosed are methods and compositions related to methods of treating, ameliorating, mitigating, slowing, arresting, preventing or reversing various diseases and conditions, including age-related obesity, age-related increases in blood lipid levels, age-related decreases in insulin sensitivity, age-related decreases in memory function, and age-related changes in eye function such as macular degeneration. The methods comprise administering nicotinamide mononucleotide (nmn) to a subject. ... The Washington University

02/22/18 / #20180049977

Hydrogel microparticle scaffold with gradients of degradability and methods thereof

Disclosed herein is a device and method for regenerating tissue using a modular scaffold having a gradient of enzymatic degradability. The disclosure further relates to scaffolds made of microparticles comprising a cross-linked water-soluble polymer or cross-linked water-soluble polymers and a process for forming thereof.. ... The Washington University

02/15/18 / #20180044183

Methods and systems for carbon nanofiber production

A system and process for producing carbon nano-materials is disclosed. A carbonate material such as li2co3 is heated via a furnace to transform into molten carbonate. ... The Washington University

02/15/18 / #20180043278

Bilayered structures for solar steam generation

The present disclosure is directed to steam generation through the efficient harvesting of solar energy. In particular, the present disclosure is directed to bilayered structures that are cost-effective, scalable and/or biodegradable that provide high steam-generation efficiency.. ... The Washington University

02/15/18 / #20180042541

Fast, continuous psychometric estimation system utilizing machine learning and associated method of use

A method and system for of computerized psychometric testing of sensory information that includes selecting stimulus parameters for a first stimulus to be applied with a stimulus inducer, applying a first stimulus on a subject with the stimulus inducer upon command of a processor, calculating a posterior probability function and an acquisition function at least based on the subject's response to the first stimulus with the processor, determining stimulus parameters for a second stimulus based on the calculated acquisition function with the processor, stimulating the subject with the second stimulus with the stimulus inducer upon command of the processor, and determining a detection threshold function by calculating the posterior probability function at least based on the subject's response to the second stimulus with the processor.. . ... The Washington University

02/08/18 / #20180037641

Antibodies to tau

This invention relates to antibodies to tau and methods of use thereof.. . ... The Washington University

02/01/18 / #20180031483

Bioplasmonic detection of biomarkers in body fluids using peptide recognition elements

Plasmonic nanotransducers and methods for label-free detection of biomarkers are disclosed. The plasmonic nanotransducers include nanostructure cores and peptide aptamers. ... The Washington University

02/01/18 / #20180030109

Tumor targeted tnf-related apoptosis inducing ligand fusion polypeptide, methods and uses therefor

Fusion polypeptides comprising a trail trimer and a targeting domain are disclosed. The targeting domain can be, in some embodiments, a sequence that binds muc16, which is prevalent on some tumor cells such as pancreatic and ovarian tumor cells. ... The Washington University

01/25/18 / #20180021462

Homing agents

The present disclosure provides peptide constructs for diagnostic imaging and therapeutic applications, using pegylated peptides which exhibit specific binding for a target molecule of interest, such as a biomarker of a disease or disorder.. . ... The Washington University

01/25/18 / #20180020977

Electrocardiogram sensor ring

An electrocardiogram (ecg) sensor has a flexible thin ring-shaped substrate configured to be worn about a patient's finger. The substrate has an inner surface and an outer surface opposite the inner surface. ... The Washington University

01/18/18 / #20180016328

Anti-tau constructs

The present invention provides anti-tau constructs. Anti-tau constructs of the invention are polynucleotide sequences encoding a polypeptide comprising at least one tau binding moiety and optionally comprising a signal peptide and/or a purification moiety. ... The Washington University

01/18/18 / #20180015207

Smart release system for growth factor delivery and combined bone and vascular growth

Embodiments of the present invention relate to structures and systems having a three-dimensional biomimetic structure with a porous biomimetic three-dimensional scaffold and a coating deposited onto a surface of the porous biomimetic three-dimensional scaffold as well as methods of using and fabricating the like.. . ... The Washington University

01/18/18 / #20180014971

Thermally conductive graft

The present disclosure provides thermally conductive grafts and methods of passively cooling a hyperthermic region and preventing epilepsy, neural inflammation, and other neurological abnormalities using a thermally conductive graft including a thermally conductive matrix disposed between two opposed surfaces.. . ... The Washington University

01/18/18 / #20180014837

Discectomy instrument

A discectomy instrument for use with a cutting tool including a flexible shaft and an implement extending from the shaft generally includes a guard including a shaft and a foot extending therefrom, wherein the foot has a port and a plurality of teeth. The instrument also includes a guide including a rod, a finger extending from the rod, and an actuator operably connected to the finger such that the finger is adjustable via the actuator. ... The Washington University

01/18/18 / #20180014720

Self-cleaning endoscope

A self-cleaning endoscope and methods of using the same are described. The self-cleaning endoscope includes a housing having a distal end and a proximal end opposite the distal end, a lens positioned at the distal end of the housing, and a lens protector coupled to the distal end of the housing external to the lens. ... The Washington University

01/11/18 / #20180010102

Toolkit for the production of post-translationally modified proteins

The present disclosure provides a system to produce soluble, folded, and post-translationally modified proteins. The system includes a fusion protein comprising a catalytic domain of an enzyme involved in post-translational protein modification and a targeting domain, and a substrate protein comprising a protein of interest and a sequence that interacts with the targeting domain. ... The Washington University

01/04/18 / #20180002747

Detection of rare sequence variants, methods and compositions therefor

The present disclosure encompasses methods of error corrected sequencing (ecs) that enable detection of very rare mutations well below the error rate of convention next generation sequencing (ngs). Further, the methods disclosed herein enable multiplex targeting of genomic dna.. ... The Washington University

01/04/18 / #20180000918

Vaccine compositions for use against enterotoxigenic escherichia coli

The present disclosure provides vaccine compositions for use against enterotoxigenic escherichia coli (etec) comprising etpa and eata. Etpa and eata are prevalent amount diverse etec isolates and display significant sequence conservation. ... The Washington University

12/28/17 / #20170371104

Tunable add-drop filter with an active resonator

An add-drop filter for transmitting at least one signal is provided. The add-drop filter includes at least two optical waveguides capable of carrying the at least one signal, and at least one active resonator coupled between the optical waveguides, wherein the at least one active resonator provides gain that counteracts losses for the at least one signal.. ... The Washington University

12/28/17 / #20170370353

Micro-cathode arc thruster

A satellite thruster increases satellite efficiency. The linear actuated μcat has a stepper motor to move the ablative electrode forward. ... The Washington University

12/28/17 / #20170369946

Blood biomarkers for respiratory infections

Methods and kits for diagnosing and/or treating a lower respiratory infection in a subject include obtaining a biological sample from the subject; detecting rna expression levels of one or more biomarkers in the biological sample and comparing the expression levels of the one or more three biomarkers to at least one invariant control marker wherein an increase or decrease in the level of expression of the one or more biomarkers as compared to the at least one invariant control marker is indicative of a lower respiratory infection.. . ... The Washington University

12/28/17 / #20170369864

Inhibition and diagnostics of emerging tetracycline resistance enzymes

The present disclosure provides compositions and methods for treating bacterial infections in a subject. The methods comprise administering a compound that binds a fad-dependent flavoenzyme and a tetracycline, analog, derivative, or pharmaceutically acceptable salt thereof.. ... The Washington University

12/28/17 / #20170368104

Induction of tolerance in lung allograft transplantation

The present disclosure relates to methods of inducing tolerance to lung allograft transplantation. These methods comprise increasing suppressor cd8+ t cells and/or suppressing deleterious cd8+ and cd4+ t cells.. ... The Washington University

12/28/17 / #20170367323

Blood substitute composition and method of use

The present disclosure provides oxygen-carrying nanoparticles, methods of making the nanoparticles, and methods of using the nanoparticles to carry oxygen in blood.. . ... The Washington University

12/21/17 / #20170365277

Emotional interaction apparatus

A system and method for emotional interaction. The system includes a robot that uses behavioral analysis automation to provide treatment and assessment of emotional communication and social skills for children with autism. ... The Washington University

12/21/17 / #20170363284

Radiant boiler for pressurized oxy-combustion and method of radiant trapping to control heat flux in high temperature particle-laden flows at elevated pressure

A boiler has a shell surrounding a vertical centerline. The shell defines an inner surface having an inner diameter and an inner length extending between an upper upstream end and a lower downstream end. ... The Washington University

12/21/17 / #20170360554

Compostions and methods for tissue repair

Provided herein are compositions and methods for treating a subject with damaged tissue, such as an injury associated with a tissue to tissue (e.g., a connective tissue-to-connective tissue or tissue to bone) interface. One aspect provides an adhesive film or adhesive layer, optionally comprising a biomaterial, tissue growth factors, including ctgf/ccn2, or cells.. ... The Washington University

12/07/17 / #20170348442

Compositions and methods for detecting ccr2 receptors

Among the various aspects of the present disclosure is the provision of compositions of imaging agents and methods for use in detecting, monitoring, and evaluating ccr2 associated diseases, disorders, and conditions.. . ... The Washington University

11/23/17 / #20170334944

Neuroactive 19-alkoxy-17(20)-z-vinylcyano-substituted steroids, prodrugs thereof, and methods of treatment using same

The present disclosure is generally directed to neuroactive 19-alkoxy-17(20)-z-vinylcyano-substituted steroids as referenced herein, and pharmaceutically acceptable salts thereof, for use as, for example, an anesthetic, and/or in the treatment of disorders relating to gaba function and activity. The present disclosure is further directed to pharmaceutical compositions comprising such compounds.. ... The Washington University

11/23/17 / #20170334865

Ddr2 inhibitors and methods of using

Compounds that inhibit activation of discoidin domain receptor 2 (ddr2) and methods of using the compounds to inhibit ddr2 activation, inhibit migration of cells expressing ddr2, and treat diseases or disorders associated with ddr2 dysfunction.. . ... The Washington University

11/23/17 / #20170332983

Systems and methods for point-of-care positron emission tomography

A positron emission tomography (pet) system is provided. The system includes a first detector panel including a first array of detectors, a second detector panel including a second array of detectors, said second detector panel being moveable relative to a point between the first detector panel and the second detector panel, a tracking system configured to detect a position of said second detector panel relative to the first detector panel while imaging a subject, a computing device in communication with the first detector panel, the second detector panel, and the tracking system, the computing device configured to receive coincidence data from the first and second detector panels, receive position data from the tracking system, wherein each coincidence datum of the received coincidence data is associated with a unique position datum of the received position data, and reconstruct a plurality of images based on the received coincidence data and the received position data.. ... The Washington University

11/09/17 / #20170324088

Method for the use of slurries in spray pyrolysis for the production of non-hollow, porous particles

A process for preparing a metal oxide-containing powder that comprises conducting spray pyrolysis that comprises aerosolizing a slurry that comprises solid-phase particles in a liquid that comprises at least one precursor compound, which comprises one or more metallic elements of at least one metal oxide, to form droplets of said slurry, and calcining the droplets to at least partially decompose the at least one precursor compound and form the metal oxide-containing powder having a non-hollow morphology.. . ... The Washington University

11/09/17 / #20170319323

Biomedical patches with aligned fibers

A structure of aligned (e.g., radially and/or polygonally aligned) fibers, and systems and methods for producing and using the same. One or more structures provided may be created using an apparatus that includes one or more first electrodes that define an area and/or partially circumscribe an area. ... The Washington University

10/26/17 / #20170307639

Tau kinetic measurements

The invention relates to in vitro methods for measuring the in vivo metabolism of tau in a subject.. . ... The Washington University

10/26/17 / #20170307590

Inhibitors of malarial and human glucose transporters and methods for identifying the inhibitors

Inhibitors of glucose transporter plasmodium falciparum hexose transporter (pfht) are provided herein. Further, a cell-based, high-throughput assay that directly measures the ability of a compound to inhibit glucose transport by pfht is provided.. ... The Washington University

10/26/17 / #20170304397

Treatment of cardiovascular disease using actrii ligand traps

Provided herein are methods of treating diseases associated with vascular calcification and/or cardiovascular disease in a subject by using the level of a biomarker, in particular, snail homolog 1 (snai1), phosphosmad2, phosphosmad3, urinary protein, dickkopf homolog 1 (dkk1), collagen type 1 alpha 1 (col1a1), activin (e.g., free activin), runt-related transcription factor 2 (runx2), alkaline phosphatase (alp), bone-specific alkaline phosphatase (bsap), c-terminal type 1 collagen telopeptide (ctx), osterix, klotho, alpha-smooth muscle actin (alpha-sma), myocardin (myocd), activin receptor type 2a (actriia), axis inhibition protein 2 (axin2), and/or smooth muscle protein 22-alpha (sm22-alpha), as an indicator(s) of responsiveness of the subject to the treatment, efficacy of the treatment, or appropriate dosage for the treatment with an activin type ii receptor signaling inhibitor. Provided herein are methods of bone resorption in a subject by using the level of a biomarker, in particular, snail homolog 1 (snai1), phosphosmad2, phosphosmad3, urinary protein, dickkopf homolog 1 (dkk1), collagen type 1 alpha 1 (col1a1), activin (e.g., free activin), runt-related transcription factor 2 (runx2), alkaline phosphatase (alp), bone-specific alkaline phosphatase (bsap), c-terminal telopeptide (ctx), osterix, klotho, alpha-smooth muscle actin (alpha-sma), myocardin (myocd), activin receptor type 2a (actriia), axis inhibition protein 2 (axin2), and/or smooth muscle protein 22-alpha (sm22-alpha), as an indicator(s) of responsiveness of the subject to the treatment, efficacy of the treatment, or appropriate dosage for the treatment with an activin type ii receptor signaling inhibitor.. ... The Washington University

10/26/17 / #20170304084

Methods and systems for controlling body parts and devices using ipsilateral motor cortex and motor related cortex

A system for controlling a body part includes a number of sensing devices that sense signals from a hemisphere of a brain. A signal translating unit translates the signals into a command signal for controlling the body part, which is on a same side of the body as the hemisphere of the brain. ... The Washington University

10/05/17 / #20170285015

Bile acid biomarkers for niemann-pick diseases, methods and uses therefor

Methods for identification and quantification of bile acids are disclosed. Bile acids in plasma, serum and/or blood such as a dried blood spot are used to identify subjects with a niemann-pick disease. ... The Washington University

08/31/17 / #20170249441

Developing predictive dose-voume relationships for a radiotherapy treatment

Embodiments develop a predictive dose-volume relationships for a radiation therapy treatment is provided. A system includes a memory area for storing data corresponding to a plurality of patients, wherein the data comprises a three-dimensional representation of the planning target volume and one or more organs-at-risk. ... The Washington University

08/31/17 / #20170247401

Compounds and methods for treating bacterial infections

The present invention encompasses compounds and methods for treating urinary tract infections.. . ... The Washington University

08/31/17 / #20170246299

Compositions and methods for treatment of pre-cancerous skin lesions

The present disclosure encompasses compositions and methods for the treatment of precancerous skin lesions. Compositions of the invention comprise a cytotoxic agent and a thymic stromal lymphopoietin (tslp) inducer.. ... The Washington University

08/17/17 / #20170237398

Phase-selective entrainment of nonlinear oscillator ensembles

A system for entraining an oscillator ensemble is disclosed that includes a plurality of oscillators in an entrained phase pattern. The system includes an entrainment device operatively coupled to each non-linear oscillator of the oscillator ensemble, and the entrainment control device is configured to deliver a 2π-periodic control signal v(θ) to all oscillators of the plurality of oscillators to induce the entrained phase pattern.. ... The Washington University

08/17/17 / #20170233356

Neuroactive substituted cyclopent[a]anthracenes as modulators for gaba type-a receptors

The present disclosure is generally directed to neuroactive substituted cyclopent[a]anthracenes as referenced herein, and pharmaceutically acceptable salts thereof, for use as, for example, an anesthetic, and/or in the treatment of disorders relating to gaba function and activity. The present disclosure is further directed to pharmaceutical compositions comprising such compounds.. ... The Washington University

08/17/17 / #20170232427

Doped graphitic carbon nitrides, methods of making and uses of the same

Carbon-doped graphitic carbon nitride (g-c3n4) compositions are synthesized from the chemical precursors melamine, cyanuric acid and barbituric acid. Phosphorus-doped g-c3n4 compositions are synthesized from the chemical precursors melamine, cyanuric acid and etidronic acid. ... The Washington University

08/17/17 / #20170232146

3d tissue-engineered bone marrow for personalized therapy and drug development

A tissue-engineered bone marrow for personalized therapy of a patient is described. The tissue-engineered bone marrow includes an autologous fibrin scaffold and a plurality of patient-derived cells isolated from the patient's bone marrow. ... The Washington University

08/17/17 / #20170231501

Super-pixel detection for wearable diffuse optical tomography

A system includes a wearable head apparatus and an electronic console. The head apparatus is configured to receive resultant light from the head of a subject. ... The Washington University

08/03/17 / #20170218465

Compositions and methods for detecting viruses in a sample

The present disclosure provides a composition comprising a panel of probes for detecting one or more viruses in a sample. The panel of probes may be used to detect viruses in a biological sample obtained from a subject.. ... The Washington University

08/03/17 / #20170217776

System and method for mass production of graphene platelets in arc plasma

A system and method for producing graphene includes a heating block, substrate, motor and collection device. The substrate is arranged about the heating block and is configured to receive heat from the heating block. ... The Washington University

07/27/17 / #20170211155

Method for predicting risk of metastasis

The invention encompasses methods and compositions for predicting the risk of metastasis. In particular, the invention encompasses a method for correlating the level of expression of one or more nucleic acid sequences with a risk of metastasis.. ... The Washington University

07/27/17 / #20170209606

Hydrogels for localized radiotherapy

Radioactive hydrogels for the delivery of localized radiotherapy, methods of making the radioactive hydrogels, and methods of using the radioactive hydrogels are disclosed. A radioisotope may be conjugated to a high molecular weight molecule, which may be encapsulated in a microparticle, where the microparticle is then dispersed within a hydrogel. ... The Washington University

07/27/17 / #20170209603

Compositions targeting radiation-induced molecules and methods of use thereof

The present invention is directed towards the compositions of peptide constructs that bind to grp78 and the methods of use thereof.. . ... The Washington University

07/20/17 / #20170203113

Method for low-voltage termination of cardiac arrhythmias by effectively unpinning anatomical reentries

A method for extinguishing a cardiac arrhythmia utilizes destructive interference of the passing of the reentry wave tip of an anatomical reentry through a depolarized region created by a relatively low voltage electric field in such a way as to effectively unpin the anatomical reentry. Preferably, the relatively low voltage electric field is defined by at least one unpinning shock(s) that are lower than an expected lower limit of vulnerability as established, for example, by a defibrillation threshold test. ... The Washington University

07/20/17 / #20170202939

Personalized cancer vaccines and methods therefor

Methods of cane r treatment based, on personalized vaccines are disclosed. Individual amino acid substitutions from tumors are revealed using whole genome sequencing, and identified as neoantigens silico. ... The Washington University

07/20/17 / #20170202475

Depression brain computer interface for the quantitative assessment of mood state and for biofeedback for mood alteration

A brain computer interface (bci) system includes an electroencephalogram (eeg) headset and a computing device communicatively coupled to the eeg headset. The computing device includes a memory, a processor and a display device. ... The Washington University

07/13/17 / #20170197912

Synthesizing pet tracers using [f-18]sulfonyl fluoride as a source of [f-18]fluoride

The present disclosure relates to the methods for the preparation of reactive [f-18]fluoride in a form of [f-18]sulfonyl fluoride suitable for efficient radiolabeling without an azeotropic evaporation step by the use of anion exchange resin and sulfonyl chloride, and its applications in the manufacturing of pet radiopharmaceuticals.. . ... The Washington University

07/06/17 / #20170189893

Nanoscale nickel phosphide catalysts for hydrotreatment

This present disclosure is directed to methods for the preparation of a hydrotreatment catalyst, such as nanoscale nickel phosphide (i.e., ni2p) particles supported on high-surface area metal oxides (e.g., silica, alumina, amorphous silica-alumina), in a manner that is compatible with conditions employed in commercial hydrotreating units. The catalyst synthesis includes impregnation, drying, and in situ reduction, and can provide highly active catalysts for the removal of s and n impurities from crude oil fractions.. ... The Washington University

07/06/17 / #20170189566

Alpha-synuclein ligands

The present invention generally relates to various compounds that are useful as α-synuclein ligands. The invention further relates to methods of using these compounds and their radiolabeled analogs for the detection of synucleinopathies, including parkinson's disease (pd).. ... The Washington University

07/06/17 / #20170188571

Systems and methods for normothermic extracorporeal organ perfusion

A system and method for perfusing an organ with a normothermic extracorporeal perfusion system is disclosed. The perfusion system is an active flow system using a centrifugal pump to aid in circulation. ... The Washington University

06/29/17 / #20170183385

Methods and compositions for red-shifted chromophore substitution for optogenetic applications

The present disclosure provides compositions and methods used for optogenetics, wherein the composition comprises an optogenetic device and a retinoid processing enzyme.. . ... The Washington University

06/29/17 / #20170181424

Blood substitute composition and method of use

The present disclosure provides oxygen-carrying nanoparticles, methods of making the nanoparticles, and methods of using the nanoparticles to carry oxygen in blood.. . ... The Washington University

06/22/17 / #20170176563

Methods for simultaneous multi-angular relaxometry and rf mapping of tissue using magnetic resonance imaging

Methods of obtaining quantitative mri images of a subject that includes fitting a theoretical model that accounts for tissue-specific relaxation properties and magnetization transfer effects to mri measured data is disclosed.. . ... The Washington University

06/15/17 / #20170166977

Biomarkers for the identification of prostate cancer and methods of use

The present disclosure provides biomarkers for the identification of prostate cancer and methods of use. The present disclosure also provide biomarkers that can be used for determining risk of developing prostate cancer, aggressiveness of prostate cancer and survival rate for subpopulations of african american males or non-hispanic white males.. ... The Washington University

06/08/17 / #a system and method for compressed-sensing ultrafast photography for two-dimensional dynamic imaging is disclosed. the system and method may capture non-repetitive time-evolving events at up to about 100 billion frames per second.

Washington University

. . ... The Washington University

06/08/17 / #20170161417

Reconfigurable optical computer

An optical-electronic device can be controlled by a bias voltage to simulate an electronic component such as a resistor, capacitor, inductor with resistor, or capacitor with resistor. The optical-electronic device can be connected in a network to perform computations, model problems, simulate properties such as physical properties (for instance heat transfer), and achieve circuit performances to carry out computations in the analog domain, all at faster speed with smaller size and at less energy.. ... The Washington University

06/01/17 / #20170154181

System and method for uncovering covert timing channels

A system detects a covert timing channel on a combinational structure or a memory structure. The system identifies the events behind conflicts, and constructs an event train based on those events. ... The Washington University

06/01/17 / #20170153243

Methods of polypeptide identification, and compositions therefor

Methods are disclosed for identifying one or more proteins or polypeptides comprised by a sample. The methods comprise determining binding of each polypeptide with respect to each binding pool of a plurality of binding pools, wherein each binding pool comprises one or more probes which bind a structure comprised by a protein or polypeptide. ... The Washington University

05/18/17 / #20170135656

Insert device for enhancing pet and mri images

Insert devices that include a rf surface coil and gamma-ray photon detector array for enhancing pet and mri images produced from integrated pet-mri scanners are disclosed. Integrated pet-mri scanners that include such insert devices as well of methods for scanning an object by use of such devices are also disclosed.. ... The Washington University

05/04/17 / #20170124255

Method and apparatus for performing similarity searching

A system and method for performing similarity searching is disclosed wherein programmable logic devices such as field programmable gate arrays (fpgas) can be used to implement bloom filters for identifying possible matches between a query and data. The bloom filters can be implemented in a parallel architecture where the different parallel bloom filters share access to the same memory units. ... The Washington University

04/20/17 / #20170108515

Antibodies to disulfated heparin disaccharide in the diagnosis of neuropathy

Methods aiding in the diagnosis of certain neuropathies are disclosed, in which the titer of antibodies to a disulfated heparin disaccharide is assessed in a test sample from a subject. Also disclosed are apparatus and kits that can be used in the methods of the invention.. ... The Washington University

04/20/17 / #20170105636

Photoacoustic flowmetry systems and methods

Methods for measuring blood flow speed within blood vessels using a pa imaging system are disclosed. The methods include position a field of view of a pa imaging system along a section of a blood vessel, introducing a pa discontinuity into the blood flow within the blood vessel upstream of the fov of the pa system, monitoring the movement of the pa discontinuity during movement through the fov of the pa imaging device, and calculate the blood flow speed using at least two measured positions and corresponding times of the pa discontinuity within the fov of the pa imaging system. ... The Washington University

04/13/17 / #20170101642

Methods of inhibiting viral replication comprising the signal peptidase complex

The present invention is directed to compositions targeting the signal peptidase complex and methods of use in treating and preventing flavivirus infection.. . ... The Washington University

04/13/17 / #20170101624

Methods of enhancing t-cell longevity and uses thereof

The present disclosure encompasses methods of enhancing t cell longevity and/or t cell function by promoting mitochondrial fusion and/or mitochondrial structural remodeling including cristae. Compositions comprising the enhanced t cells may be used in adoptive cellular immunotherapy.. ... The Washington University

04/06/17 / #20170095577

Noninvasive imaging of focal atherosclerotic lesions using fluorescence molecular tomography

The present disclosure provides compositions comprising an oligopeptide comprising a fragment of a natriuretic peptide, wherein the fragment comprises the sequence arg-ile-asp-arg-ile (seq id no:1), and a detectable label. Further disclosed are methods of imaging atherosclerotic plaque by optical imaging using a peptide composition.. ... The Washington University

04/06/17 / #20170095526

Method of treating low blood pressure

A method for treating a patient suffering from one of septic shock, acute kidney injury, severe hypotension, cardiac arrest, and refractory hypotension, but not from myocardial infarction, is provided. The method includes administering a therapeutically effective dose of angiotensin ii, or ang ii, to the patient.. ... The Washington University

03/30/17 / #20170089897

Distinguishing flavivirus infection using a recombinant mutant envelope protein

The present invention relates to mutant peptides of the e protein of the west nile virus and other flaviviruses useful for discriminating flaviviral infections, as well as kits, methods and uses related thereto.. . ... The Washington University

03/30/17 / #20170089689

System and method for quantifying deformation, disruption, and development in a sample

A computer-implemented method for determining a quantification of the deformation of the sample is implemented using a computer device in communication with a memory. The method includes receiving, by the computer device, a first image of the sample and a second image of the sample. ... The Washington University

03/30/17 / #20170087519

Composite nanostructures having a crumpled graphene oxide shell

Composite nanostructures having a crumpled graphene oxide shell and a nanoparticle selected from titanium dioxide, silver and magnetite within the shell are disclosed. The nanostructures may be incorporated into a filtration membrane suitable for purifying water for targeted separations and for human consumption.. ... The Washington University

03/23/17 / #20170080243

Methods and devices for three-stage ventricular therapy

Methods and apparatus for a three-stage ventricular cardioversion and defibrillation therapy that treats ventricular tachycardia and fibrillation at low energy levels. An implantable therapy generator adapted to generate and selectively deliver a three-stage ventricular therapy and at least two leads operably each having at least one electrode adapted to be positioned proximate the ventricle of the patient. ... The Washington University

03/16/17 / #20170074811

Integrated epr nmr with frequency agile gyrotron

A frequency agile gyrotron for use in combination with an nmr system is disclosed. The frequency agile gyrotron combined with epr-nmr magic angle spinning resonators and cryogenic sample cooling may increase the sensitivity of solid state nmr with dnp.. ... The Washington University

03/16/17 / #20170073610

Microencapsulation of chemical additives

The present disclosure relates to new and optimized processes for the preparation of micro- and nano-scale capsules containing lubricant chemical additives. The present disclosure also relates to micro- and nano-scale capsules prepared by such processes, which are useful in a variety of applications, including automotive lubricants, diesel lubricants, industrial lubricants, metal-working lubricants, coolants, and process fluids. ... The Washington University

03/16/17 / #20170071889

Dna methyltransferases for the treatment and prevention of arthritis

The present disclosure is directed to compositions and methods for treating osteoarthritis comprising increasing the expression of dnmt3b and/or inhibiting aminobutyrate aminotransferase.. . ... The Washington University

03/09/17 / #20170067112

Sequences associated with tdp-43 proteinopathies and methods of using the same

The present invention provides nucleic acids and peptides, and methods of using the nucleic acids and peptides to identify subjects at risk for a tdp-43 proteinopathy. The invention also provides for an array comprising the nucleic acids and peptides of the invention.. ... The Washington University

03/09/17 / #20170065669

Antithrombotic nanoparticle

The present invention encompasses an antithrombotic nanoparticle and use thereof.. . ... The Washington University

03/02/17 / #20170058297

Compositions and methods for site specific recombination at asymmetric sites

The present invention relates to enzymes, compositions and methods for catalyzing site specific recombination at asymmetric sites.. . ... The Washington University

02/23/17 / #20170052194

Molecules and methods for iterative polypeptide analysis and processing

Reagents and methods for the digital analysis of proteins or peptides are provided. Specifically provided herein are proteins for identifying the n-terminal amino acid or n-terminal phosphorylated amino acid of a polypeptide. ... The Washington University

02/16/17 / #20170044269

Adenoviral targeting, compositions and methods therefor

Polypeptides are disclosed comprising, in n-terminal-to-c-terminal order: an n-terminal segment of ad5 fiber tail sequence; at least 2 pseudorepeats of an ad5 fiber shaft domain sequence; a portion of a third ad5 fiber shaft domain sequence; a carboxy-terminal segment of a 14 fibritin bacteriophage trimerization domain sequence; a linker sequence; and a camelid single chain antibody sequence. A camelid single chain antibody sequence can be against a human carcinoembryonic antigen. ... The Washington University

02/09/17 / #20170038326

Highly selective nanostructure sensors and methods of detecting target analytes

A nanostructure sensing device comprises a semiconductor nanostructure having an outer surface, and at least one of metal or metal-oxide nanoparticle clusters functionalizing the outer surface of the nanostructure and forming a photoconductive nanostructure/nanocluster hybrid sensor enabling light-assisted sensing of a target analyte.. . ... The Washington University

02/09/17 / #20170037521

Process for the production of ammonia from air and water

The present disclosure relates to a simple one-pot process for the production of ammonia. The process involves electrolysis of air and water using a molten or concentrated aqueous hydroxide electrolyte in the presence of an iron catalyst. ... The Washington University

02/09/17 / #20170037079

Neuroactive 13, 17-substituted steroids as modulators for gaba type-a receptors

The present disclosure is generally directed to neuroactive 13, 17-substituted steroids as referenced herein, and pharmaceutically acceptable salts thereof, for use as, for example, an anesthetic, and/or in the treatment of disorders relating to gaba function and activity. The present disclosure is further directed to pharmaceutical compositions comprising such compounds.. ... The Washington University

02/09/17 / #20170035759

Treatment of parasitic diseases using kdac inhibitor compounds

Methods of using kdac inhibitor compounds for the treatment of various parasitic diseases are described.. . ... The Washington University

02/02/17 / #20170028034

Mutant huntingtin-mediated protein dysfunction

The present invention relates to methods of inhibiting neurodegeneration in a subject suffering from or genetically at risk and/or destined to develop huntington's disease comprising increasing, in neurons of the subject, the activity of the tim23 mitochondrial protein import complex.. . ... The Washington University

01/26/17 / #20170022263

Tumor targeted tnf-related apoptosis inducing ligand fusion polypeptide, methods and uses therefor

Fusion polypeptides comprising a trail trimer and a targeting domain are disclosed. The targeting domain can be, in some embodiments, a sequence that binds muc16, which is prevalent on some tumor cells such as pancreatic and ovarian tumor cells. ... The Washington University

01/26/17 / #20170020402

Implantable and bioresorbable sensors

Provided herein are implantable and bioresorbable sensors that are specifically designed to be implanted, function for an operational lifetime, and at some point after the operational lifetime to be resorbed by the body in such a manner so as to avoid having to remove any part of the sensor. This avoids a second impact on the patient otherwise associated with sensor removal. ... The Washington University

01/19/17 / #20170015660

Sigma-2 receptor ligand drug conjugates as antitumor compounds, methods of synthesis and uses thereof

Methods and compositions for treating cancers such as pancreatic cancer and synovial sarcoma are disclosed. Compounds comprising a sigma-2 receptor-binding moiety and a ferroptosis-inducing moiety are described. ... The Washington University

01/19/17 / #20170014420

Use of nk-1 receptor antagonists for treating hypomagnesemia, neurogenic inflammation, and cardiac dysfunction associated with egfr-blocking drugs

The present disclosure provides methods for alleviating or preventing the negative physiological side effects associated with the administration of egfr blocking therapeutics. The disclosure provides, inter alia, methods for treating or preventing: hypomagnesemia, cardiac dysfunction, and skin lesions, which are induced by egfr blocking drugs, by administering an nk-1 receptor antagonist.. ... The Washington University

01/19/17 / #20170014066

Task-less optical mapping of brain function using resting state functional connectivity

A method for utilizing an optical system for taskless mapping of brain function includes determining a time series of dynamic light measurements for a plurality of spatially distributed source-detector pairs, receiving the dynamic light measurements over a period of time using the source-detector pairs without dependence on either a task or a change in physiological condition, generating a plurality of temporal correlations between regions of a brain for the light measurements based on the time series of the spatially distributed source-detector pairs and the received dynamic light measurements, producing at least one map of a respective strength of each of a plurality of temporal correlations, producing overlapping source-detector pairs measurements using diffuse optical tomography (dot) geometries, reconstructing data representative of the dynamic light measurements into an image space using at least one dot algorithm, and co-registering dot voxel images obtained by the reconstruction to anatomical information.. . ... The Washington University

01/12/17 / #20170007724

Imaging and treatment of pathophysiologic conditions by cerenkov radiation

The present disclosure discloses methods and compositions for a administering cerenkov radiation-induced therapy (grit). In an aspect, the invention encompasses a composition comprising at least two radiation-sensitive molecules. ... The Washington University

01/05/17 / #20170001076

Low dimple coverage and low drag golf ball

A golf ball has a lower drag than conventional golf balls due to the arrangement of dimples on the outer surface of the golf ball, which arrangement produces a correspondingly lower percentage of outer surface area that is covered by the dimples. In particular, dimple coverage area may be less than 70%, and more specifically between about 18.6% and about 60.8%, of the outer surface area. ... The Washington University








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