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The Wistar Institute Of Anatomy And Biology patents


Recent patent applications related to The Wistar Institute Of Anatomy And Biology. The Wistar Institute Of Anatomy And Biology is listed as an Agent/Assignee. Note: The Wistar Institute Of Anatomy And Biology may have other listings under different names/spellings. We're not affiliated with The Wistar Institute Of Anatomy And Biology, we're just tracking patents.

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Contructs for enhancing immune responses

Chimeric protein constructs including a herpesvirus glycoprotein D (gD) and a heterologous polypeptide that interact with herpes virus entry mediator (HVEM) and enhance and enhance an immune response against the heterologous polypeptide and methods for their use are provided.... The Wistar Institute Of Anatomy And Biology

Methods and compositions for treatment of metastatic and refractory cancers and tumors

A method of treating a mammalian subject with cancer comprises administering to said subject having a cancer, e.g., a metastatic or refractory cancer or tumor, a small molecule inhibitor of a target signaling molecule of the MEK/MAPK pathway that impairs T cell activation, and administering to said subject a molecule... The Wistar Institute Of Anatomy And Biology

Methods and compositions for treating cancer

A nucleic acid sequence is provided that encodes a chimeric protein comprising a ligand that comprises a naturally occurring or modified follicle stimulating hormone sequence, e.g., an FSHp sequence, or fragment thereof, which ligand binds to human follicle stimulating hormone (FSH) receptor, linked to either (a) a nucleic acid sequence... The Wistar Institute Of Anatomy And Biology

Methods and compositions for treatment or diagnosis of cancers related to gabra3

Compositions and methods for diagnosing and treating breast cancer, including metastatic breast cancer, are provided. In one aspect, a diagnostic composition comprising a reagent which is capable of specifically complexing with, or identifying, GABRA3 is provided. In another aspect, a method of detecting breast cancer in a subject comprising measuring... The Wistar Institute Of Anatomy And Biology

Methods and compositions for diagnosis of ectopic pregnancy

Methods and compositions are provided for diagnosing ectopic pregnancy in a mammalian subject by detecting changes in expression of the selected genes, gene fragments or transcripts or expression products, or changes in the expression levels of one or more of proteins or peptide fragments, identified in Table 2 and FIGS.... The Wistar Institute Of Anatomy And Biology

Combination therapies targeting mitochondria for cancer therapy

Pharmaceutical compositions for the treatment of cancer are provided. In one embodiment the composition comprises Gamitrinib and a P13K inhibitor selected from PX-866, AZD6482, LY294002. BEZ235, GSK458, GDCO941, ZSTK474, BKM120 and GSK2636771B. Methods of treating cancer are also provided. The present invention is based in part on the inventor's discovery... The Wistar Institute Of Anatomy And Biology

Methods and compositions for treatment of metastatic and refractory cancers and tumors

A method of treating a mammalian subject with cancer comprises administering to said subject having a cancer, e.g., a metastatic or refractory cancer or tumor, a small molecule inhibitor of a target signaling molecule of the MEK/MAPK pathway that impairs T cell activation, and administering to said subject a molecule... The Wistar Institute Of Anatomy And Biology

Small molecule hsp70 inhibitors

In an effort to discover therapies for treating HSP70 related diseases, a previously unidentified hydrophobic pocket was found in the C-terminal domain of DnaK and of human HSP70. A novel chemical scaffold was also discovered for identifying compounds that treat diseases related to this hydrophobic pocket. The compounds have the... The Wistar Institute Of Anatomy And Biology

Small molecule modulators of prb inactivation

The present invention provides a small molecule treatment of diseases/conditions caused by a virus carrying a viral oncoprotein. In one embodiment, the virus which carries the viral oncoprotein is HPV. The small molecule useful herein includes thiadiazolin-3,5-dione compounds having an optionally substituted aryl group bound to one nitrogen atom of... The Wistar Institute Of Anatomy And Biology

Methods and compositions for inhibiting mitochondrial trafficking

Methods for reducing, inhibiting or preventing cancer metastasis comprise blocking the movement of mitochondria within a cancer cell. Other methods involve interrupting or preventing oxidative phosphorylation pathways or respiration pathways in the cancer cell. In one embodiment, mitochondrial movement is induced by contact of the cell with PI3K inhibitors or... The Wistar Institute Of Anatomy And Biology








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