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Thermo Fisher Scientific Inc patents


Recent patent applications related to Thermo Fisher Scientific Inc. Thermo Fisher Scientific Inc is listed as an Agent/Assignee. Note: Thermo Fisher Scientific Inc may have other listings under different names/spellings. We're not affiliated with Thermo Fisher Scientific Inc, we're just tracking patents.

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Multi-reflection mass spectrometer with deceleration stage

Disclosed herein is a multi-reflection mass spectrometer comprising two ion mirrors spaced apart and opposing each other in an x direction, each mirror elongated along a drift direction y orthogonal to the direction x, and an ion injector for injecting ions as an ion beam into the space between the ion mirrors at an inclination angle to the x direction. Along a first portion of their length in the drift direction y the ion mirrors converge with a first degree of convergence, and along a second portion of their length in the drift direction y the ion mirrors converge with a second degree of convergence or are parallel, the first portion of their length being closer to the ion injector than the second portion and the first degree of convergence being greater than the second degree of convergence.. ... Thermo Fisher Scientific Inc

Methods and systems for high resolution melt analysis of a nucleic acid sequence

Described herein are methods and systems for analyzing and visualizing hrm data from a double-stranded nucleic acid. The hrm data is generally characterized by a plurality of data points each including a signal value associated with the concentration of a double-stranded nucleic acid in a sample and a temperature value associated with a the temperature of the sample. ... Thermo Fisher Scientific Inc

Method and apparatus for automated analysis

An apparatus for pretreatment of a desired sample in a discrete fluid analyzing instrument includes a frame rotatably mounted on or within the discrete fluid analyzing instrument with a column for immobilizing at least one substance or analyte from the sample. The substance or analyte is reversibly immobilized. ... Thermo Fisher Scientific Inc

Elemental analysis of organic samples

A method of imaging analyte elements in an organic sample includes providing the sample as a layer on a substrate and reacting the sample on the substrate to produce one or more volatile products that leave the sample while the one or more elements remain in the sample. A majority of the sample layer by weight is removed from the substrate by the reaction and the remaining sample layer is enriched in the one or more elements which are not spatially disturbed by the reaction. ... Thermo Fisher Scientific Inc

Method and apparatus for automated analysis

An apparatus for pretreatment of a sample of whole blood in a discrete fluid analyzing instrument comprises automated means for handling and analyzing the sample and means for performing a pretreatment step on the sample or a sub-sample of the sample. The means for pretreatment are used for immobilizing at least one substance or analyte from the sample or sub-sample wherein the substance or analyte is reversibly immobilized. ... Thermo Fisher Scientific Inc

Methods and compositions for selecting sirna of improved functionality

Efficient sequence specific gene silencing is possible through the use of sirna technology. By selecting particular sirnas by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. ... Thermo Fisher Scientific Inc

Elemental analyzer

An analysis system for analysing the constituents of a sample of material is provided. A reference supply conduit supplies a source of a first gas. ... Thermo Fisher Scientific Inc

Sample preparation apparatus and method for elemental analysis spectrometer

A sample preparation apparatus for an elemental analysis system comprising a sample combustion and/or reduction and/or pyrolysis arrangement for receiving a sample of material to be analysed, and producing therefrom a sample gas flow containing atoms, molecules and/or compounds; a gas chromatography (gc) column into which the sample gas flow is directed; a heater for heating at least a part of the gc column; and a controller for controlling the heater. The controller is configured to control the heater so as to increase the temperature of at least the part of the gc column whilst the sample gas flow in the gc column elutes.. ... Thermo Fisher Scientific Inc

Method for identification of the monoisotopic mass of species of molecules

The invention concerns a method for identification of the monoisotopic mass or a parameter correlated the mass of the isotopes of the isotope distribution of at least one species of molecules contained in a sample and/or originated from a sample by at least an ionization process, comprising measuring a mass spectrum of the sample with a mass spectrometer, dividing at least one range of measured m/z values of the mass spectrum into fractions, assigning at least some of the fractions to one processor of several provided processors, deducing for each of the at least one species of molecules an isotope distribution of their ions having a specific charge z, deducing from at least one deduced isotope distribution the monoisotopic mass or a parameter correlated the mass of the isotopes of the isotope distribution of the species of molecules.. . ... Thermo Fisher Scientific Inc

Sample vessel

A sample vessel (1, 11) for transferring and analyzing a sample with analyzer instrument, which sample vessel comprises an elongated vessel body (2, 12) for containing the sample and a hinged cap (3, 13) connected in top end area of the vessel body, and the cross-section of the vessel body (2, 12) on a transversal plane in relation to the lengthwise center axis of the vessel body the inner surface of the vessel body is rotationally asymmetrical in relation to the lengthwise center axis, wherein the sample vessel (1, 11) comprises a surface (5, 15) extending upwards from the vessel body, which surface partially surrounds the edge of the cap (3, 13), when the cap is in closed position.. . ... Thermo Fisher Scientific Inc

Targeted mass analysis

A mass spectrometer comprises: an ion source that generates ions having an initial range of mass-to-charge ratios; an auxiliary ion detector, downstream from the ion source that receives a plurality of first ion samples derived from the ions generated by the ion source and determines a respective ion current measurement for each of the plurality of first ion samples; a mass analyser, downstream from the ion source that receives a second ion sample derived from the ions generated by the ion source and to generate mass spectral data by mass analysis of the second ion sample; and an output stage that establishes an abundance measurement associated with at least some of the ions generated by the ion source based on the ion current measurements determined by the auxiliary ion detector.. . ... Thermo Fisher Scientific Inc

Temperature-compensated rectifying component

A temperature-compensated rectifying component is configured to receive an input signal and comprises: a diode part, for rectifying the received input signal and providing a rectified output signal thereby, the diode part having an operational temperature; and a temperature compensation controller, configured to control a power dissipated by the diode part over a predetermined period of time, such that an average of the operational temperature over the predetermined period of time meets pre-set criteria. This may be used in a rf detector for generating a dc level from a rf input signal, which may form part of a control circuit for setting an amplitude of an rf potential for supplying to an electronic amplifier in an analytical instrument, such as an ion optical device.. ... Thermo Fisher Scientific Inc

Method of calibrating a mass spectrometer

A method of calibrating a mass spectrometer is disclosed. The mass spectrometer includes a first quadrupole, a second mass analyzer and a detection means. ... Thermo Fisher Scientific Inc

Temperature-compensated electronic apparatus

A temperature-controlled electronic apparatus, comprises: a circuit board; a plurality of electronic components, mounted on the circuit board in an arrangement to form at least one electronic circuit; a temperature sensor, configured to measure a temperature of the at least one electronic circuit; and a heat-generating component, configured to be controlled by a temperature control circuit, the temperature control circuit being configured to control an amount of heat generated by the heat-generating component in response to the temperature measured by the temperature sensor. The plurality of electronic components are arranged on the circuit board to lie on one of one or more paths, each path of the one or more paths being defined by a respective circle having a radius.. ... Thermo Fisher Scientific Inc

02/08/18 / #20180040463

Ms/ms data processing

A method of identifying precursor ion species from their fragments comprises obtaining mass spectra of a plurality of precursor ion species and their fragments to high mass accuracy. The fragment mass spectrum, obtained from fragmentation of multiple precursor ion species, is then scanned it identify pairs of fragments whose combined mass matches the mass of one of the precursor ion species. ... Thermo Fisher Scientific Inc

02/08/18 / #20180037935

Transposon nucleic acids comprising a calibration sequence for dna sequencing

Transposon nucleic acids comprising a transposon end sequence and a calibration sequence for dna sequencing in the transposon end sequence. In one embodiment, the transposon end sequence is a mu transposon end. ... Thermo Fisher Scientific Inc

02/08/18 / #20180036735

Sample vessel rack, method for locking sample vessels in a sample vessel rack and sample vessel rack system

A sample vessel rack (1), which comprises a frame (2) with a plurality of openings (3) in the upper surface of the frame for sample vessels (9), and a locking plate member (5) movable in a plane parallel to the upper surface of the frame (2) of the rack from a releasing position to a locking position and back, wherein the removal of the sample vessels (9) from the rack is prevented when the locking plate member is in the locking position, the openings (3) of the upper surface of the frame (2) comprises slots (12) formed on their side, and in the locking position a part of the locking plate member (5) sets itself in the area of the slots. The invention also relates to such a method and a sample vessel rack system.. ... Thermo Fisher Scientific Inc

02/08/18 / #20180036734

Reaction vessel and apparatus and method for opening and closing a reaction vessel

A method and apparatus for opening a reaction vessel having a body forming a volume for liquid, and a lid. In the method at least one reaction vessel is placed on a transport vehicle and the reaction vessel is positioned on the vehicle so that the vessel's rotation about its own axis is prevented. ... Thermo Fisher Scientific Inc

02/01/18 / #20180033604

Method and apparatus for injection of ions into an electrostatic ion trap

A method of injecting ions into an electrostatic trap, comprising: generating ions in an ion source; transporting the ions from the ion source to an ion store downstream of the ion source; releasing the ions from the ion store to an ion guide downstream of the ion store; and accelerating the ions from the ion guide as a pulse into an orbital electrostatic trap for mass analysis, wherein the average velocity of the ions as the ions exit from the ion guide is substantially higher than the average velocity of the ions as they exit from the ion store, wherein there is a delay between releasing the ions from the ion store and accelerating the ions from the ion guide. Also an apparatus suitable for the method.. ... Thermo Fisher Scientific Inc

02/01/18 / #20180030396

Sampling device and combination of sampling device and sample vessel

This invention relates to a sampling device comprising a shaft and a sample collection portion removably connected with the shaft, wherein the connection site between the shaft and the sample collection portion is weakened. The invention relates also to a combination of a sampling device comprising a shaft and a removable sample collection portion and a sample vessel configured to receive sample collection portion from the shaft.. ... Thermo Fisher Scientific Inc

02/01/18 / #20180029039

Bottle compartment for analyzer instrument

A bottle compartment (1, 21) for an analyzer instrument, which bottle compartment comprises a frame (3) with a location (4) for a bottle (10, 23) of liquid, and a tube (7, 24) for aspiration of liquid from a bottle at the location for a bottle by the analyzer instrument, wherein the bottle compartment (1, 21) comprises a handle mechanism (2, 22) connected turnably to the frame (3), which handle mechanism in an open position allows access to the location (4) for insertion and removal of a bottle (10, 23) and in a closed position prevents access to the location, and that the tube (7, 24) for aspiration of liquid is connected to the handle mechanism so that when the handle mechanism is turned to the open position the end of the tube is simultaneously moved from the bottle at the location and when the handle mechanism is turned to the closed position the end of the tube is simultaneously moved inside the bottle at the location.. . ... Thermo Fisher Scientific Inc

01/25/18 / #20180021746

Use of a reactor, methods, and device for quantitatively obtaining molecular hydrogen from substances

The invention relates to the use of a reactor, methods, and devices for the quantitative recovery of molecular hydrogen from solid, liquid, or gaseous substances which contain hydrogen and which have heteroatoms, as well as to reactors. In this case, the reactors have material containing chromium. ... Thermo Fisher Scientific Inc

01/04/18 / #20180005809

Integrated hybrid nems mass spectrometry

A hybrid mass spectrometer comprising: an ion source for generating ions from a sample, a first mass spectral system comprising a nanoelectromechanical mass spectral (nems-ms) system, a second mass spectral system including at least one mass analyzer adapted to separate the charged particles according to their mass-to-charge ratios, and an integration zone coupling the first and second mass spectral systems, the integration zone including at least one directional device for controllably routing the ions to a selected one or both of the first and second mass spectral systems for analysis thereby. The second system can be an orbital electrostatic trap system. ... Thermo Fisher Scientific Inc

12/28/17 / #20170372882

Method of tandem mass spectrometry

A method of tandem mass spectrometry is disclosed. A quasi-continuous stream of ions from an ion source (20) and having a relatively broad range of mass to charge ratio ions is segmented temporally into a plurality of segments. ... Thermo Fisher Scientific Inc

12/28/17 / #20170370890

Gas inlet system for isotope ratio analyzer and method of determining an isotope ratio

A gas inlet system for introducing gas into an isotope ratio analyzer, the gas inlet system including a reference system comprising: a first supply of a reference gas having a first known isotope ratio; a supply of a carrier gas, wherein the supplies of reference gas and carrier gas are each connected by respective reference and carrier gas lines to a first mixing junction where the reference gas and carrier gas combine; a mixing zone connected downstream of the first mixing junction wherein the combined reference gas and carrier gas mix together; an exit line for transporting the mixed gas from the mixing zone to the isotope ratio analyzer; and an opening on the exit line, wherein the opening is downstream of the mixing zone. Also provided is a method of determining an isotope ratio.. ... Thermo Fisher Scientific Inc

12/07/17 / #20170352530

Ion injection to an electrostatic trap

Ions are injected into an orbital electrostatic trap. An ejection potential is applied to an ion storage device, to cause ions stored in the ion storage device to be ejected towards the orbital electrostatic trap. ... Thermo Fisher Scientific Inc

12/07/17 / #20170352528

Apparatus and method for static gas mass spectrometry

A method of static gas mass spectrometry is provided. The method includes the steps of: introducing a sample gas comprising two or more isotopes to be analyzed into a static vacuum mass spectrometer at a time, t0; operating an electron impact ionization source of the mass spectrometer with a first electron energy below the ionization potential of the sample gas for a first period of time that is following t0 until a time t1; and operating the electron impact ionization source with a second electron energy at least as high as the ionization potential of the sample gas for a second period of time that is after time t1. ... Thermo Fisher Scientific Inc

12/07/17 / #20170349904

Methods and compositions for selecting sirna of improved functionality

Efficient sequence specific gene silencing is possible through the use of sirna technology. Be selecting particular sirnas by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. ... Thermo Fisher Scientific Inc

11/30/17 / #20170343684

System and method of stabilization of a gamma and neutron detecting device

A spectroscopic gamma and neutron detecting device includes a scintillation detector that detects gamma and thermal neutron radiation, the scintillation detector including signal detection and amplification electronics, and a stabilization module configured to measure a pulse height spectrum of neutron radiation, determine a thermal neutron peak position in the neutron pulse height spectrum originating from cosmic ray background radiation, monitor the thermal neutron peak position in the neutron pulse height spectrum during operation of the spectroscopic gamma and neutron detecting device, and adjust the signal detection and amplification electronics based on the thermal neutron peak position in the neutron pulse height spectrum, thereby stabilizing the spectroscopic gamma and neutron detecting device.. . ... Thermo Fisher Scientific Inc

11/23/17 / #20170336374

Elemental analysis system and method

An elemental analysis system includes a reactor having at least one reduction reaction zone including a metal zeolite that can reduce nitrogen oxides (nox) to molecular nitrogen (n2) by selective catalytic reduction. Correspondingly, a method of elemental analysis includes providing a reactor having at least one reduction reaction zone including a metal zeolite and reducing nitrogen oxides (nox) to molecular nitrogen (n2) by selective catalytic reaction on the metal zeolite.. ... Thermo Fisher Scientific Inc

11/09/17 / #20170322161

Apparatus and method for controlling an atomic emission spectrometer

A controller (316) and method for establishing safe operation of an atomic emission spectrometer (aes) to analyse a sample (100) arranged on a sample holder (102) of the aes. The controller (316) is configured to receive a measurement of at least one test parameter indicative of the arrangement of the sample (100) on the sample holder (102). ... Thermo Fisher Scientific Inc

10/26/17 / #20170307446

Sensor container for mounting a temperature sensor, and associated refrigerator

A refrigerator for storing products includes a sensor container configured to position at least one temperature sensor within a refrigerated interior in a cabinet of the refrigerator. The sensor container includes a main body portion enclosing a hollow interior space configured to receive a ballast liquid, and a plurality of dry wells which each extend generally horizontally between a closed end within the hollow interior space and an open end. ... Thermo Fisher Scientific Inc

09/28/17 / #20170278692

Multi-reflection mass spectrometer

A multi-reflection mass spectrometer is provided comprising two ion-optical mirrors, each mirror elongated generally along a drift direction (y), each mirror opposing the other in an x direction, the x direction being orthogonal to y, characterized in that the mirrors are not a constant distance from each other in the x direction along at least a portion of their lengths in the drift direction. In use, ions are reflected from one opposing mirror to the other a plurality of times while drifting along the drift direction so as to follow a generally zigzag path within the mass spectrometer. ... Thermo Fisher Scientific Inc

09/21/17 / #20170270282

High-resolution mass spectrometer and methods for determining the isotopic anatomy of organic and volatile molecules

A mass spectrometer including an entrance slit, an energy filter, a momentum filter and a detector array, the entrance slit, energy filter and momentum filter being configured to provide molecular analyte ions to the detector array at a mass resolution of about 20,000 or greater. A method for determining the isotopic composition of an analyte in a sample includes converting the analyte to molecular analyte ions, separating the molecular analyte ions using an entrance slit, separating the molecular analyte ions according to their energy levels, separating the molecular analyte ions according to their momenta, detecting two or more of the molecular analyte ions at a mass resolution of about 20,000 or greater to produce molecular analyte ion data; and analyzing the molecular analyte data to determine the isotopic composition of at least a portion of the analyte.. ... Thermo Fisher Scientific Inc

09/21/17 / #20170267982

Polymerase compositions and uses

A composition having nucleic acid polymerase activity, which comprises an active nucleic acid polymerase and an excess amount of a non-functional mutant nucleic acid polymerase protein, wherein the non-functional mutant nucleic acid polymerase protein stabilizes the active nucleic acid polymerase against loss of polymerase activity.. . ... Thermo Fisher Scientific Inc

09/21/17 / #20170266667

Thermal cycler with optimized sample holder geometry

The invention concerns a thermal cycler and a microtiter plate. The cycler comprises a sample holder having a first surface and a surface and means for automated, controlled heating and cooling of the sample holder. ... Thermo Fisher Scientific Inc

09/14/17 / #20170258229

Devices and methods for leveling shelves in a laboratory climatic cabinet

A shelf support for leveling a shelf of a laboratory climatic cabinet is provided. The shelf support includes a shelf support body configured to be secured to a wall of the laboratory climatic cabinet and to support the shelf and at least one shelf leveling mechanism associated with the shelf support body. ... Thermo Fisher Scientific Inc

09/07/17 / #20170254756

Method and apparatus for optical measurement of liquid sample

A method and an apparatus for optical measurement of a liquid sample placed in a sample well where the sample in the sample well is exposed to excitation light at first wavelength from an excitation light source, which excitation light generates a collection of singlet state oxygen molecules from donor molecules in the liquid sample, said singlet state oxygen molecules reacting with acceptor molecules in the liquid sample causing said acceptor molecules to emit chemiluminescence emission light at second wavelength, which second wavelength is shorter than said first wavelength, and where the emission light produced by the excitation light is measured with a detector, characterized in that the excitation light source is a led.. . ... Thermo Fisher Scientific Inc

08/31/17 / #20170248517

High-accuracy mid-ir laseer-based gas sensor

A gas sensor system is provided, comprising: a gas cell operable so as to receive a sample gas; a vacuum system fluidically coupled to the gas cell operable to maintain the sample gas within the gas cell at a sub-ambient pressure; a pressure sensor operable to sense a pressure of the sample gas; a thermally insulated enclosure having the gas cell therein; a heat source or heat exchanger operable to influence an interior temperature of the thermally insulated enclosure; a light source within the thermally insulated enclosure operable to provide a mid-infrared (mid-ir) light into and through the gas cell; a photodetector within the thermally insulated enclosure operable to receive the attenuated mid-ir; and a control system electronically coupled to the vacuum system and to the pressure sensor operable to maintain the sample gas within the gas cell at the predetermined pressure to within one torr (1 torr).. . ... Thermo Fisher Scientific Inc

08/10/17 / #20170227488

Chlorine detection with pulsed amperometric detection

A method of measuring oxidant in an aqueous composition using an electrode system comprising a membrane permeable to a species to be measured, a cathode situated behind the membrane, and an electrolyte between the membrane and cathode. Embodiments of the method may include contacting the membrane and an anode with the aqueous composition, and measuring the current between the cathode and anode in response to a first voltage applied between them. ... Thermo Fisher Scientific Inc

07/27/17 / #20170213717

Quadrupole mass spectrometer

In mass spectrometry, ion optics process a received ion beam into an output ion beam travelling in an output direction and having a spatial distribution in a plane perpendicular to the output direction elongated in one dimension of the plane relative to the other dimension of the plane and defines an axis of elongation thereby. A quadrupole ion optical device comprises first and second pairs of opposing elongated electrodes, receiving the output ion beam travelling along the output direction and defining an acceptance axis in a plane perpendicular to the direction of elongation of the first and second pairs of opposing elongated electrodes. ... Thermo Fisher Scientific Inc

07/20/17 / #20170204454

Antibodies that bind thermophilic dna polymerases

This disclosure relates to antibodies that bind thermophilic family b dna polymerases. Related uses, methods, and compositions are also provided.. ... Thermo Fisher Scientific Inc

07/20/17 / #20170204384

Thermophilic dna polymerase mutants

This disclosure relates to thermophilic family b dna polymerases comprising a neutral amino acid residue at a certain position near the c-terminus of the catalytic domain, which corresponds to a position occupied by a basic amino acid residue in wild-type pfu polymerase. Related uses, methods, and compositions are also provided. ... Thermo Fisher Scientific Inc

07/13/17 / #20170200596

Irms sample introduction system and method

A sample introduction system for a spectrometer comprises a desolvation region that receives or generates sample ions from a solvent matrix and removes at least some of the solvent matrix from the sample ions. A separation chamber downstream of the desolvation region has a separation chamber inlet communicating with the desolvation region, for receiving the desolvated sample ions along with non-ionised solvent and solvent ion vapours. ... Thermo Fisher Scientific Inc

06/29/17 / #20170184552

Heated transfer line

A flexible, foldable light-weight gas chromatography transfer line suitable for connecting a gas chromatograph (gc) to a spectrometer, such as a mass spectrometer or optical spectrometer, in particular to the ion source of the spectrometer, such as an inductively coupled plasma (icp) ion source. The transfer line has a heating arrangement that allows maintaining an even temperature profile, which improves quality of spectra. ... Thermo Fisher Scientific Inc

06/22/17 / #20170178884

Liquid sample introduction system and method, for analytical plasma spectrometer

A liquid sample introduction system for a plasma spectrometer includes a sample container for holding a liquid sample, a surface acoustic wave (saw) nebulizer, arranged to receive a liquid sample from the sample container, an electronic controller for supplying electrical power to the saw nebulizer so as to produce a surface acoustic wave on a surface of the saw nebulizer, for generating an aerosol from the supplied sample liquid, and an aerosol transport arrangement for receiving the aerosol from the saw nebulizer and carrying it into a plasma or flame of a spectrometer. The electronic controller is further configured to control the electrical power to the saw nebulizer so as to permit adjustment of the aerosol parameters, and to control the aerosol transport arrangement so as to permit adjustment of the aerosol delivery into the plasma or flame of the spectrometer.. ... Thermo Fisher Scientific Inc

06/15/17 / #20170166851

Petri dish

The present invention relates to a petri dish comprising a dish body which comprises a bottom wall and a side wall which extends along an outer circumference of the bottom wall, the bottom wall and the side wall of the dish body form an upper opening space adapted to accommodate cultures; a dish lid adapted to cover the upper opening space from above the dish body, the dish lid comprises a top wall and a side wall which extends along an outer circumference of the top wall, wherein the dish body and the dish lid are two independent members that are detachable, and the side wall of the dish body is formed on the outer side thereof with a ring for gripping that extends circumferentially, and the ring for gripping having an outer diameter larger than that of the dish lid. The petri dish according to the present invention has a simple structure. ... Thermo Fisher Scientific Inc

06/01/17 / #20170154169

Data processing device and method for the evaluation of mass spectrometry data

A data processing device comprises a processor unit adapted to process a plurality of initial data vectors provided by a chromatograph and/or a mass spectrometer, the processing being carried out in one, two or more processing steps producing items of processed data, and a storage unit adapted to save and retrieve initial data vectors and/or items of processed data, in particular processed data vectors or identified compounds, and/or items of additional data, in particular properties of the sample introduced in the mass spectrometer. Each item of processed data and/or additional data is connected to at least one initial data vector, and wherein the processor unit is adapted to group, select and/or modify initial data vectors and/or items of processed data according to one or more items of additional data.. ... Thermo Fisher Scientific Inc

05/18/17 / #20170140914

Addition of reactive species to icp source in a mass spectrometer

Disclosed is a method of inductively coupled plasma mass spectrometry (icp-ms), comprising steps of introducing at least one sample comprising at least one sample species, and at least one reactive species, into an inductively coupled plasma source, such that at least one molecular adduct ion of the at least one reactive species and the at least one sample species is formed; transferring the at least one molecular adduct ion into a collision cell that is arranged between the inductively coupled plasma source and at least one mass analyzer, transferring the at least one molecular adduct ion, or a product thereof, into the at least one mass analyzer, and analyzing the mass of the at least one molecular adduct ion, or the product thereof, in the at least one mass analyzer. Also disclosed is a mass spectrometer that is adapted to perform the method.. ... Thermo Fisher Scientific Inc

05/04/17 / #20170120235

Pipette comprising imaging device element

A pipette comprising a cylinder with a piston movable inside the cylinder for aspiring and dispensing liquid, and a handle portion for gripping the pipette, wherein the pipette further comprises an imaging device element for obtaining images that assist the use of the pipette.. . ... Thermo Fisher Scientific Inc

04/27/17 / #20170117130

Electrostatic trap

An electrostatic trap such as an orbitrap is disclosed, with an electrode structure. An electrostatic trapping field of the form u′(r, Φ, z) is generated to trap ions within the trap so that they undergo isochronous oscillations. ... Thermo Fisher Scientific Inc

04/27/17 / #20170114339

Inactivation method

The present invention relates to the field of thermostable enzymes, methods for their inactivation, and related uses, kits and reagents. In particular, the invention relates to a method for reversible inactivation of thermophilic enzymes by chemical modification under aqueous or non-aqueous conditions.. ... Thermo Fisher Scientific Inc

04/13/17 / #20170100712

Pipette with a tracking system

A pipette is described which includes a piston for aspirating liquid into and dispensing out of a container in the pipette. The pipette is provided with at least one tracking element which is able to count the magnitude of some variable or variables relating to the amount of use of the pipette, at least one operating device for creating a limit magnitude for each variable, and for giving information when the limit value is exceeded. ... Thermo Fisher Scientific Inc

03/23/17 / #20170084447

Mass spectrometer

An elemental mass spectrometer uses a mass filter to select ions from ions received from an ion source and transmit the selected ions. A reaction or collision cell receives the transmitted ions and reacts or collides these with a gas to provide product ions thereby. ... Thermo Fisher Scientific Inc

03/23/17 / #20170082585

Automated system for sample preparation and analysis

A sample preparation and analysis system. The system 10 includes a sample preparation system 12 and a sample analysis system 14. ... Thermo Fisher Scientific Inc

03/23/17 / #20170081646

Dna polymerases

A dna polymerase mutant comprising a taq dna polymerase amino acid sequence with a mutation at one or more of the following selected amino acid positions: e189k, e230k, e507k, h28r, l30r, g38r, f73v, h75r, e76a, e76g, e76k, e90k, k206r, e315k, a348v, l351f, a439t, d452n, g504s, e507a, d551n, l552r, i553v, d578n, h676r, q680r, d732g, e734g, e734k, f749v; wherein the polymerase mutant exhibits relative to wild-type dna polymerase increased polymerase speed, increased affinity to dna substrate and/or increased resistance to a dna polymerase inhibitor; and wherein, when the mutation is e507k in combination with two or more further mutations or the mutation is q680r in combination with four or more further mutations, at least one of the further mutations is at one of the selected amino acid positions; and when the mutation is i553v, this is not in combination with d551s.. . ... Thermo Fisher Scientific Inc

03/02/17 / #20170059403

Optimization of the laser operating point in a laser absorption spectrometer

An operating value of a first laser parameter of a laser device in a laser absorption spectrometer is optimized. The wavelength of laser device emitted light is adjusted by the first or a second laser parameter. ... Thermo Fisher Scientific Inc

02/23/17 / #20170053790

Method of mass separating ions and mass separator

An analyzer for separating ions according to their time of flight comprising two opposing ion mirrors abutting at a first plane, each mirror comprising inner and outer field-defining electrode systems elongated along an analyzer axis, the outer field-defining electrode system surrounding the inner field-defining electrode system. The outer field-defining electrode system of one mirror comprises two sections, the sections abutting at a second plane, comprising a first section between the first plane and the second plane, and a second section adjacent to the first section. ... Thermo Fisher Scientific Inc

02/16/17 / #20170047217

Dynamic range improvement for isotope ratio mass spectrometry

In a mass spectrometer, a mass-to-charge dispersive element separates received ions spatially according to their mass-to-charge ratios, to provide a dispersed ion beam thereby. An ion detection arrangement that detects the dispersed ion beam comprises: at least one primary ion detector, each detecting spatially separated ions having mass-to-charge ratios within a respective desired range and each providing a respective main beam signal based on its respective detected ions; and at least one secondary ion detector, each detecting ions having mass-to-charge ratios outside all of the desired ranges simultaneously with the at least one primary ion detector detecting the spatially separated ions and each providing a respective background signal based on its respective detected ions. ... Thermo Fisher Scientific Inc

02/16/17 / #20170047216

Mirror lens for directing an ion beam

An electrostatic dual-mode lens assembly is provided for selectively transmitting or reflecting an ion beam in a mass spectrometer. The assembly comprises at least one electrode that provides a switchable electric field that, during a first mode of operation, directs an ion beam that enters the assembly along a first path so that the beam is transmitted through the assembly along the first path, and during a second mode of operation, directs an ion beam that enters the assembly along the first path so that the ion beam is reflected by the electric field and exits the assembly along a second path. ... Thermo Fisher Scientific Inc

02/16/17 / #20170047214

Detector and slit configuration in an isotope ratio mass spectrometer

A method of configuring a faraday detector in a mass spectrometer is described. The mass spectrometer defines a central ion beam axis i, and the faraday detector is moveable relative to the central ion beam axis i. ... Thermo Fisher Scientific Inc

02/16/17 / #20170047210

Quantitative measurements of elemental and molecular species using high mass resolution mass spectrometry

A method for generating a mass spectrum of sample ions using a multi-collector mass spectrometer is disclosed. The mass spectrometer includes a spatially dispersive mass analyser to direct the sample ions into a detector chamber. ... Thermo Fisher Scientific Inc

02/09/17 / #20170040152

Ion detection

Mass analyzers and methods of ion detection for a mass analyzer are provided. An electrostatic field generator provides an electrostatic field causing ion packets to oscillate along a direction. ... Thermo Fisher Scientific Inc

02/02/17 / #20170031033

Elemental analysis of organic samples

A method of imaging analyte elements in an organic sample includes providing the sample as a layer on a substrate and reacting the sample on the substrate to produce one or more volatile products that leave the sample while the one or more elements remain in the sample. A majority of the sample layer by weight is removed from the substrate by the reaction and the remaining sample layer is enriched in the one or more elements which are not spatially disturbed by the reaction. ... Thermo Fisher Scientific Inc

02/02/17 / #20170029861

Protein production

A method for producing from host cells a heterologous polypeptide or protein comprising at least one cysteine residue in a reduced state. The method cultured the host cells in a culture medium comprising a reducing agent; and recovered the heterologous polypeptide or protein comprising at least one cysteine residue in a reduced state from the host cells or from the culture medium, where the host cells comprise a nucleic acid encoding the heterologous protein or polypeptide, and where the reducing agent is capable of permeating the plasma membrane of the host cells.. ... Thermo Fisher Scientific Inc

01/26/17 / #20170025261

Mass spectrometer vacuum interface method and apparatus

A mass spectrometer vacuum interface can include a skimmer apparatus having a skimmer aperture and an internal surface. A method of operating the mass spectrometer vacuum interface can include establishing an outwardly directed flow along the internal surface of the skimmer apparatus.. ... Thermo Fisher Scientific Inc

01/26/17 / #20170021348

Electronic pipette

An electronic pipette comprising a piston actuated in a cylinder by a motor, a control system for carrying out pipette operations, and a user interface for operating the pipette, which user interface comprises a display, wherein the main menu of the user interface comprises a user defined shortcut to a specific pipetting application.. . ... Thermo Fisher Scientific Inc

01/19/17 / #20170018416

Control of gas flow

The invention relates to a gas inlet system for providing gas into an analytical apparatus, comprising at least a first and a second flow restriction that are arranged on a gas inlet line, a gas flow control line connected to the gas inlet line, a gas flow controller on the gas control line, and valves for controlling gas flow in the gas inlet line and the gas control line. Also provided is a method of controlling gas flow into an analytical apparatus.. ... Thermo Fisher Scientific Inc

01/19/17 / #20170015980

Phi29 dna polymerase mutants having increased thermostability and processivity

Mutants of bacteriophage phi29 dna polymerase with increased protein stability and increased half-life, compared to wild type dna polymerase. The disclosed mutants are more stable in reaction mixtures with or without dna. ... Thermo Fisher Scientific Inc

01/12/17 / #20170009291

Sample processing apparatus and method

The invention relates to a sample processing apparatus comprising a holder for a microtiter plate comprising a plurality of microwells, optical measurement unit for measuring optical responses of samples dosed to the microwells, and a computing unit configured to analyze the optical responses in order to detect dosing failures in said plurality of microwells, and if a dosing failure has been detected in one or more of the microwells, to communicate the existence of the dosing failure to a user of the apparatus through signaling means or to store data indicative of the dosing failure to data storage means for further use. In particular, the invention relates to detecting dosing failures in before, during and after a pcr process.. ... Thermo Fisher Scientific Inc

01/12/17 / #20170009288

Method for controlled dna fragmentation

A composition and method for controlled in vitro fragmentation of nucleic acids. A transposase forms catalytically active complexes with a modified transposon end that contains within its end sequence degenerate, apurinic/apyrimidinic sites, nicks, or nucleotide gaps, to fragment or shear a target nucleic acid sample in a controlled process. ... Thermo Fisher Scientific Inc








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