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Translational Genomics Research Institute patents


Recent patent applications related to Translational Genomics Research Institute. Translational Genomics Research Institute is listed as an Agent/Assignee. Note: Translational Genomics Research Institute may have other listings under different names/spellings. We're not affiliated with Translational Genomics Research Institute, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "T" | Translational Genomics Research Institute-related inventors


Methods for detecting and treating fungal infections

Methods are provided to detect and treat a fungal infection. The method may include the steps of obtaining a sample from a subject suspected of having a fungal infection, detecting an uncharacterized fungal protein (cimg_09001/cpsg_01366) in the sample, and determining the presence on the fungal infection if the uncharacterized fungal protein is detected.. ... Translational Genomics Research Institute

Quality assessment of circulating cell-free dna using multiplexed droplet digital pcr

The present invention provides a method of determining integrity and/or quantity of cell free dna (cfdna) in a bio logical sample comprising amplifying target sequences with at least a first primer/probe set and at least a second primer probe/set, amplifying the target sequences of differing lengths, and monitoring for detection of the labels of the oligonucleotide probes, and determining the integrity and/or quantity of the cfdna based on the level of detection of the label of the oligonucleotide probe from the first primer/probe set compared to the level detection of the label of the oligonucleotide probe from the second primer/probe set. The present invention also provides methods for generating a library with the cfdna for sequencing and analysis.. ... Translational Genomics Research Institute

Methods of detecting breast cancer brain metastasis with genomic and epigenomic biomarkers

The present invention provides a method of diagnosing a breast cancer central nervous system (cns) metastasis in a subject, comprising determining the expression level of at least one biomarker in a subject-derived brain or breast tissue comparing the subject-derived expression level with a normal control level obtained from normal brain or breast cells; and correlating an increase or decrease of the subject-derived expression level as compared to the normal control level to a diagnosis of a breast cancer cns metastasis. The present invention also provides a method for the treatment of a breast cancer cns metastasis in a subject comprising administering to the subject an inhibitor of an overexpressed gene associated with cns metastasis.. ... Translational Genomics Research Institute

Methods and kits used in classifying adrenocortical carcinoma

The invention encompasses methods and kits used to detect biomarkers that may be used to predict disease outcome in adrenocortical carcinoma patients.. . ... Translational Genomics Research Institute

Method of characterizing sequences from genetic material samples

Among other aspects provided herein is a method describing the use of single nucleotide polymorphism (snp) genotyping microarrays to resolve whether genetic material (such as genomic dna) derived from a particular individual is present in a genetic material mixture (such as a complex genomic dna mixture) is disclosed. Furthermore, it is demonstrated that the identification of the presence of genetic material (such as genomic dna) of specific individuals within a series of complex genomic mixtures is possible.. ... Translational Genomics Research Institute

Genetic signature of vulnerability to inhibitors of base excision repair (ber) in cancer

The invention relates to the identification of genetic signatures and expression profiles that are a part of the base excision repair (ber) pathway, a major dna repair pathway that modifies base lesions. In one embodiment, the present invention provides a method of determining responsiveness of treatment by ber inhibitors for malignant glioma by determining the presence of a low level of expression of apex 1, a low level of expression of apex 2, and a high level of expression of mpg.. ... Translational Genomics Research Institute

Biomarkers and methods of use thereof

Methods useful in the prediction and detection of a triple negative cancer subtype using biomarkers are provided herein.. . ... Translational Genomics Research Institute

Canine autoimmune conditions and diagnosis and treatment thereof

The disclosure includes methods of identifying a dog at risk of developing a an autoimmune disease or condition, for example a hypothyroid disease or condition, comprising testing whether the dog exhibits one or more selected single nucleotide polymorphisms (snps), together with diagnostic kits for carrying out such methods, methods of treatment or prophylaxis of such autoimmune disease or condition, e.g., comprising administering an effective amount of tea extract to a dog in need thereof, and a canine diet or supplement comprising tea extract, useful for treatment of prophylaxis of such autoimmune disease or condition, or for maintenance of thyroid health in a dog.. . ... Translational Genomics Research Institute

Methods used to treat cancer

The invention encompasses methods used in the sensitization and treatment of cancer based upon the expression of sgef.. . ... Translational Genomics Research Institute

Autophagy inhibitors

The present invention relates to compounds of formula iii, formula 111(a), formula v, formula v(a), formula a, formula a 1, formula a2, formula a 3, or a pharmaceutically acceptable salt thereof that are useful as pharmaceutical agents, individually and/or in a combination with a chemotherapeutic agent: plx-4032 (vemurafenib), or the catalytic mtor inhibitor azd8055, to treat a cancer and/or a cancer metastasis, for example a cancer harboring a braf protein kinase mutation and/or a hras protein mutation. Also, a method of treating and/or preventing malaria in a subject, the method comprising administering a therapeutically effective amount of a compound of formula a, formula a 1, formula a2, formula a 3, or a pharmaceutically acceptable salt thereof to the subject in need.. ... Translational Genomics Research Institute








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