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Trustees Of Boston University
Trustees Of Boston University And President And Fellows Of Harvard College
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Trustees Of Boston University patents


Recent patent applications related to Trustees Of Boston University. Trustees Of Boston University is listed as an Agent/Assignee. Note: Trustees Of Boston University may have other listings under different names/spellings. We're not affiliated with Trustees Of Boston University, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "T" | Trustees Of Boston University-related inventors


 new patent  Method and composition for reducing nitrates, nitrites, and/or hydroxylamine in water using a homogeneous reduced copper tetra-substituted fluorinated pinacolate ligand catalyst complex

A method for reducing nitrates, nitrites, and/or hydroxylamine in water using a homogeneous reduced copper tetra-substituted fluorinated pinacolate ligand catalyst complex. The method includes dissolving a copper(II) tetra-substituted fluorinated pinacolate ligand pre-catalyst complex in water having an excess amount of nitrates, nitrites, and/or hydroxylamine therein. The dissolved copper(II) tetra-substituted fluorinated... Trustees Of Boston University

 new patent  Gene expression-based biomarker for the detection and monitoring of bronchial premalignant lesions

Disclosed herein are assays and methods for the identification of premalignant lesions, as well as methods of determining the likelihood that such premalignant lesions will progress to lung cancer. Also disclosed are methods and assays that are useful for monitoring the progression of premalignant lesions to lung cancer. The assays... Trustees Of Boston University

Wireless fluidic readout platform for sensors

Near-field magnetic resonance is used to retrieve information stored in sensors passing through a fluidic channel in a fluidic medium, and can also be used for recharging a power source in the sensors. The sensors have been previously injected into a downhole and/or reservoir environment, and are then retrieved in... Trustees Of Boston University

Glycerol-based polycarbonates

The invention provides polymer compositions, compounds, processes, and methods of use of the polymers for drug delivery, biodegradable consumer plastics, or solvents for Li-based batteries or supercapacitors. The invention is based, at least in part, on the discovery that poly(glyceric acid carbonate)s and alkyl functionalized poly(1,2 glycerol carbonates) and poly(glyceric... Trustees Of Boston University

Method and system for oblique backscattering ultrasound imaging

An Oblique Backscatter Ultrasound imaging system includes a transceiver that has an US source and a plurality of US detectors configured in receive signals off axis from the US source. While the system is arranged in a reflective configuration, the device produces transmissive contrast signals to yield improved images. The... Trustees Of Boston University

Large scale video search using queries that define relationships between objects

One embodiment of the present solution is a relationship-based video server system. The server system is programmed to provide a platform for large scale video search based on relationships between objects in video segments, and the platform executes search based on probabilistically discriminative objects and relationships.... Trustees Of Boston University

Electrode comprising heavily-doped ceria

An electrode can include a functional layer having an Ln2MO4 phase, where Ln is at least one lanthanide optionally doped with a metal and M is at least one 3d transition metal, and a heavily-doped ceria phase. An electrochemical device or a sensor device can include the electrode.... Trustees Of Boston University

Diagnostic and prognostic methods for lung disorders using gene expression profiles from nose epithelial cells

The present invention provides methods for diagnosis and prognosis of lung cancer using expression analysis of one or more groups of genes, and a combination of expression analysis from a nasal epithelial cell sample. The methods of the invention provide far less invasive method with a superior detection accuracy for... Trustees Of Boston University

Therapeutic and research application of pdcl3

Described herein are novel compositions comprising, for example, PDCL3 polypeptides having VEGFR-2 inhibitory activity, inhibitory PDCL3 antibodies and PDCL3-binding fragments thereof, or PDCL3 inhibitory nucleic acid molecules, and methods of their use in anti-angiogenesis and anti-tumor proliferation and invasiveness therapies, such as the treatment of cancer, as well as the... Trustees Of Boston University

Methods and systems for monitoring, diagnosing, and treating chronic obstructive pulmonary disease

A novel set of 98 genes expressed in the respiratory tract epithelium that serve as biomarkers for measuring chronic obstructive pulmonary disease (COPD) activity are provided. Methods of classifying the (COPD) status of a subject are provided. Systems for expression-based classification of COPD disease status are provided. Methods of treating... Trustees Of Boston University

Immunomodulating compositions and methods of use thereof

This invention is directed to β-1-6-glucans, compositions and devices comprising the same, and methods of use thereof in modulating immune responses. The β-1-6-glucans of certain embodiments of the invention are enriched for O-acetylated groups and/or conjugated to a solid support or linked to a targeting moiety.... Trustees Of Boston University

Biological analog-to-digital and digital-to-analog converters

Described herein are novel biological converter switches that utilize modular components, such as genetic toggle switches and single invertase memory modules (SIMMs), for converting analog inputs to digital outputs, and digital inputs to analog outputs, in cells and cellular systems. Flexibility in these biological converter switches is provided by combining... Trustees Of Boston University

Structured substrates for optical surface profiling

This disclosure provides methods and devices for the label-free detection of target molecules of interest. The principles of the disclosure are particularly applicable to the detection of biological molecules (e.g., DNA, RNA, and protein) using tandard SiO2-based microarray technology.... Trustees Of Boston University

Compositions comprising riboregulators and methods of use thereof

The invention provides novel and versatile classes of riboregulators, including inter alia activating and repressing riboregulators, switches, and trigger and sink RNA, and methods of their use for detecting RNAs in a sample such as a well and in modulating protein synthesis and expression.... Trustees Of Boston University

Chemical functionalization of solid-state nanopores and nanopore arrays and applications thereof

Chemical functionalization of solid-state nanopores and nanopore arrays and applications thereof. Nanopores are extremely sensitive single-molecule sensors. Recently, electron beams have been used to fabricate synthetic nanopores in thin solid-state membranes with sub-nanometer resolution. A new class of chemically modified nanopore sensors are provided with two approaches for monolayer coating... Trustees Of Boston University

Ultraviolet light emitting diodes

The invention provides ultraviolet (UV) light-emitting diodes (LEDs). The UV LEDs can comprise abase layer including p-type SiC or p-type AlGaN, an active layer, and an n-AlGaN layer, wherein the active layer is disposed between the base layer and the n-AlGaN layer. In some embodiments, the absorption losses in p-SiC... Trustees Of Boston University

Inhibitors of fibroproliferative disorders and cancer

The present invention generally relates to the field of treatment of fibroproliferative diseases and disorders and cancer. Embodiments of the present invention generally relate to compositions, methods and kits comprising an inhibitor of a portion of the N-terminal pro-fibrotic domain (PFD) of Aortic Carboxypeptidase-Like Protein (ACLP), and in some embodiments,... Trustees Of Boston University

Method and apparatus to assist foot motion about the pronation axis

An apparatus that assists foot movement includes a normally twisted plate configured to interact with the foot. The foot has a pronation axis, and the normally twisted plate is biased and configured to twist about a plate axis that substantially approximates the pronation axis in response to a load received... Trustees Of Boston University

Dna recombinase circuits for logical control of gene expression

The invention provides, inter alia, recombinase-based systems that provide for integrated logic and memory in living cells such as mammalian cells. The nucleic acid cassettes, switches, and systems described herein allow for control of gene expression or gene regulation. The invention also provides nucleic acid-based switches for adopted T-cell therapy.... Trustees Of Boston University

Riboregulator compositions and methods of use

The invention provides novel and versatile classes of riboregulators, including inter alia activating and repressing riboregulators, switches, and trigger and sink RNA, and methods of their use for detecting RNAs in a sample such as a well and in modulating protein synthesis and expression.... Trustees Of Boston University

System and neuro-stimulation

A neuro-stimulation system employs a includes a stimulator which may include electrode devices and/or vibration elements. A controller may be employed to drive the stimulating elements with an electrical signal. In response to the electrical signal, the stimulating elements deliver electrical and/or mechanical stimulation to the body part. The stimulation... Trustees Of Boston University

Therapeutic agent for emphysema and copd

The invention described herein relates to methods of treating emphysema and COPD with a GHK tripeptide. The invention further relates to methods of determining the state of the lungs using biomarkers described herein.... Trustees Of Boston University

Methods and assays relating to huntingtons disease and parkinson's disease

Described herein are methods for the diagnosis, prognosis, and treatment of neurological conditions, e.g. Huntington's Disease, relating to the misregulation of miRNAs in such conditions.... Trustees Of Boston University

Detection of electromagnetic radiation using nonlinear materials

An apparatus for detecting electromagnetic radiation within a target frequency range is provided. The apparatus includes a substrate and one or more resonator structures disposed on the substrate. The substrate can be a dielectric or semiconductor material. Each of the one or more resonator structures has at least one dimension... Trustees Of Boston University

Proton-motive force stimulation to potentiate aminoglycoside antibiotics against persistent bacteria

Provided herein are compositions and methods to improve treatment of chronic infections, and reduce, delay, or inhibit formation of biofilms, using specific combinations of aminoglycoside antibiotics and high, localized concentrations of one or more PMF stimulating compounds. These novel methods are easily adapted to clinical settings as toxicity and efficacy... Trustees Of Boston University

Robo2 inhibitory compositions comprising slit2-binding extracellular domain of robo2

Provided herein are methods for the treatment of chronic kidney disease and proteinuria and for the diagnosis of chronic kidney disease and monitoring the effects of treatment on the progression of chronic kidney disease and proteinuria based on unexpected roles for the SLIT-ROBO signaling pathway in the regulation of podocyte... Trustees Of Boston University

Inhibitors of late sv40 factor (lsf) as cancer chemotherapeutics

The present invention is directed to methods, compositions and kits for treatment of cancer, e.g. heptacellular carcinoma. In some embodiments, the present invention discloses the use of a small-molecule compound of formula (I)-(XXVI) and (III′) as disclosed herein to inhibit transcription factor Late SV40 Factor (LSF) for treatment of cancer,... Trustees Of Boston University

Blood glucose control system

Techniques are used for adaptation of drug-administration parameters that control insulin delivery in a blood glucose control system. One technique provides long-term adaptation of a nominal basal infusion rate, adapting to longer-term changes in a patient's needs due to growth, illness, hormonal fluctuations, physical activity, aging, etc. Another technique provides... Trustees Of Boston University

Dark current mitigation with diffusion control

A photosensor device for reducing dark current is disclosed. The photosensor device includes a photon absorbing layer and two or more photosensor diffusions in said absorbing layer. The photosensor diffusions in the absorbing layer have edges of their diffusions separated in said absorbing layer by less than two minority carrier... Trustees Of Boston University

System and embedding phase and amplitude into a real-valued unipolar signal

A system for embedding phase and amplitude into a real valued unipolar signal suitable for intensity modulation (IM) by optical transmitters. The system includes a complex-to-unipolar conversion engine configured to receive complex symbols in Cartesian format and convert the complex symbols from the Cartesian format to a polar coordinate format... Trustees Of Boston University

Anti-despr monoclonal antibody targeted therapy and imaging for cancer and stroke

Provided herein are novel compositions comprising anti-DEspR antibodies and fragments thereof derived from 6G8G7 and 7C5B2 anti-DEspR variant antibodies, including fully human, composite engineered human, humanized, monoclonal, and polyclonal anti-DEspR antibodies and fragments thereof, and methods of their use in a variety of therapeutic applications. The compositions comprising the anti-DEspR... Trustees Of Boston University

Gm3 functionalized nanoparticles

Embodiments disclosed herein relates to ganglioside GM3-containing mixed lipids nanoparticles having an overall size between 60-100 nm, the making thereof and the uses. The nanoparticles selectively targeted to CD169+ expressing cells such as dendritic cells and macrophage. The nano-particles are endocytosed by the CD169+ expressing cells.... Trustees Of Boston University

Methods and compositions for treating viral or virally-induced conditions

Provided are methods and compositions for the prevention and/or treatment of viral conditions, virally-induced conditions and inflammatory conditions. The methods can comprise administering to a subject a viral inducing agent with an antiviral agent, and optionally an additional agent. The viral inducing agent can be a HDAC inhibitor administered orally.... Trustees Of Boston University

Inhibitors of late sv40 factor (lsf) as cancer chemotherapeutics

The present invention is directed to methods, compositions and kits for treatment of cancer, e.g. heptacellular carcinoma. In some embodiments, the present invention discloses the use of a small-molecule compound of formula (I)-(XXVI) and (III′) as disclosed herein to inhibit transcription factor Late SV40 Factor (LSF) for treatment of cancer,... Trustees Of Boston University

Methods for treating viral disorders

... Trustees Of Boston University

02/02/17 / #20170027994

Differentiation of stem cells into thyroid tissue

Embodiments herein relate in vitro methods of stem cell differentiation into thyroid hormone producing cells and tissues, and methods of use of these cells.... Trustees Of Boston University

02/02/17 / #20170029904

Classification of myc-driven b-cell lymphomas

Methods for diagnosing Burkitt lymphoma (BL) and diffuse large B-cell lymphoma (DLBCL) based on a diagnostic score, as well as determining MYC activity levels and selecting treatments based on a MYC activity score.... Trustees Of Boston University

01/19/17 / #20170016821

Polarization enhanced interferometric imaging

An imaging system uses polarized light to illuminate the target and then uses a polarization filter to remove the light that is reflected from the target without modification. The target can include one or more anisotropic objects that scatter the light and alter the polarization state of the reflected light... Trustees Of Boston University

01/19/17 / #20170016878

Apparatus, systems & methods for non-contact rheological measurements of biological materials

An acoustical non-contact levitation system and method for eliciting the deformation response of biological samples, coupled with the data analysis to yield quantitative measures of established time-dependent viscoelastic material properties. Embodiments allow for measurement to occur in near-real-time by way of a computer. In use, a biological sample is placed... Trustees Of Boston University

01/12/17 / #20170007824

Minimally invasive splaying microfiber electrode array and methods of fabricating and implanting the same

An electrode array having a splayable bundle of fibers having heat-sharpened tips. A method of manufacturing an electrode array including heat-sharpening a tip of each of a plurality of fibers; and bundling the plurality of fibers. A method of implanting an electrode array into a subject, the electrode array having... Trustees Of Boston University

01/05/17 / #20170003405

Direction sensitive neutron detector

A neutron detector includes a pressure vessel, an electrically conductive field cage assembly within the pressure vessel and an imaging subsystem. A pressurized gas mixture of CF4, 3He and 4He at respective partial pressures is used. The field cage establishes a relatively large drift region of low field strength, in... Trustees Of Boston University








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