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Tufts University patents


Recent patent applications related to Tufts University. Tufts University is listed as an Agent/Assignee. Note: Tufts University may have other listings under different names/spellings. We're not affiliated with Tufts University, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "T" | Tufts University-related inventors


 new patent  Fabrication of macroporous monodisperse hydrogel microspheres

A macroporous polymeric hydrogel microsphere that contains poly(ethylene glycol), chitosan, and water. The hydrogel microsphere, having a diameter of 50-250 gm and a mesh size of 5-100 nm, is capable of transporting biomolecules conjugated to it. Also disclosed is a method of fabricating the microsphere based on a micromolding technique... Tufts University

Uridine monophosphate and triphosphate derivatives, compositions and methods of use

This disclosure relates to uridine nucleoside derivatives, compositions comprising therapeutically effective amounts of those nucleoside derivatives and methods of using those nucleoside derivatives or compositions in treating disorders that are responsive to compounds, such as agonists, of P2Y6 receptor, e.g., neuronal disorders, including neurodegenerative disorders (e.g., Alzheimer's disease, Parkinson's disease)... Tufts University

Compositions and methods for treating inflammatory diseases

The invention provides compositions and methods for treating inflammatory diseases, such as cardiac or hepatic inflammatory diseases, involving the use of parasite-derived neurotrophic factor (PDNF), or fragment of PDNF.... Tufts University

Shape memory silk materials

The present application relates to silk fibroin-based materials, methods for making and using the same. Provided materials exhibit shape memory characteristics while showing comparable or better volumetric swelling, biocompatibility and/or degradability when compared to current memory polymers derived from either natural or synthetic materials.... Tufts University

Two-layer nanofiltration membranes

A two-layer membrane including a polymer layer and a support layer, the polymer layer being disposed on a surface of the support layer. The polymer layer, having a pore size of at most 50 nm and a thickness of 5 nm to 10 μm, is formed of an amphiphilic copolymer... Tufts University

Zwitterionic copolymers for fouling resistant filtration membranes

A graft copolymer including zwitterionic repeat units and hydrophobic repeat units, in which the zwitterionic repeat units constitute 2-60 wt % of the graft copolymer and each of the hydrophobic repeat units is characterized in that a homopolymer formed thereof is miscible with polyvinylidene fluoride, polysulfone, poly ether sulfone, polyvinyl... Tufts University

Vhh based binding antibodies for anthrax and botulinum toxins and methods of making and using therefor

Methods, compositions and kits are provided for treating a subject exposed to or at risk for exposure to a disease agent, methods, compositions and kits having a pharmaceutical composition including at least one recombinant binding protein or a source of expression of the binding protein, wherein the binding protein neutralizes... Tufts University

Maximum entropy quantization of link state

An approach to communication of a quantized value includes communicating one or more parameters characterizing a distribution of the values, and then repeatedly quantizing values according to the distribution and communicating the transmitted values. In some examples, the quantizing of the values is according to a maximum-entropy codebook determined from... Tufts University

Methods and compositions for vaccinating a subject for a sexually transmitted pathogen

Purified Chlamydia major outer membrane protein (MOMP) has been observed to induce protection against genital and respiratory challenge in mice. MOMP contains variable domains that are highly immunogenic and elicit cross-serovar neutralizing monoclonal and polyclonal antibodies and T cell responses in animal and human models. Examples herein provide a method... Tufts University

Drifting keyboard

A keyboard entry system for use in a touch screen display in which a user touches the display to move a keyboard on the display. The user moves the keyboard until a desired key lies under a fixed cursor. To type the key, the user lifts his finger.... Tufts University

Three dimensional printing of bio-ink compositions

3D printing of biopolymer-based inks provides for manufacturing a broad range of products with desirable properties. A print nozzle may be charged to form a cone-shaped ink droplet to result in increased resolution, more reliable contact with irregular surfaces, and a mechanism to control contacting the ink to the print... Tufts University

Microphysiologic methods and compositions

The present invention provides, among other things, methods for producing platelets including the steps of providing a silk membrane about 2 μm and 100 μm thick, inclusive, contacting the silk membrane with a porogen to form a porous silk membrane comprising at least one silk wall defining a lumen, associating... Tufts University

Compositions, methods and kits for treating complement related disorders

Compositions, methods and kits are provided for treating complement related disorders in a subject with protein in combination having protein fusions of at least two of a CD46 protein, a CD55 protein and a CD59 protein or with a recombinant chimeric protein having at least two of a CD46 protein,... Tufts University

Lymphangiogenesis inhibitors for cancer and for graft survival

Compositions and methods are provided for treating and/or preventing lymphangiogenesis in a subject by using an inhibitor of a galectin-8 protein in an amount effective to inhibit or to modulate an activity of the galectin-8 protein or a portion thereof sufficient to inhibit the lymphangiogenesis associated with cancer, corneal injury,... Tufts University

3d graphene transistor

A field effect transistor having a channel that comprises three-dimensional graphene foam. The subject matter of the invention concerns a three dimensional field-effect transistor having a channel based on graphene foam and the use of ionic liquid as a gate. The graphene foam is made of a three-dimensional network of... Tufts University

System and measuring phase delay and amplitude of a near infra-red signal in animal tissue

A system and method, for measuring phase delay and amplitude of a near infrared signal emanating from tissue of an animal subject in response a near infrared signal input to such tissue, operate by processing a signal from an optical detector and a corresponding signal from an optical detector emulation... Tufts University

Integrated circuit with multi-threshold bulk finfets

A method for manufacturing a FinFET having a fm that has a fm body includes selecting a desired electrical performance parameter, selecting a base dimension of the fin, identifying a combination of fin-body doping and fin-geometry that causes the FinFET to have the desired electrical performance parameter, doping the fin... Tufts University

Biopolymer-based preservation of perishable products

Disclosed herein are biopolymer-based coatings and products incorporating such coatings. Related methods and use are also provided.... Tufts University

Synthesizer with cymbal actuator

An apparatus for making music includes a cymbal, an acoustic transducer, a signal-processing system that receives a first signal from the acoustic transducer and that generates a second signal based on a property of the first signal, and a classifier that determines a particular manner in which the cymbal was... Tufts University

Methods of identifying and formulating food compounds that modulate phenotype-related targets

This invention relates generally to (but is not limited to) identifying food compounds that have an impact on a phenotype of interest in a subject, and more particularly to identifying a phenotype-related target, identifying a stimulus (e.g., a pharmaceutical agent) that modulates that target, and identifying food compounds exhibiting similarity... Tufts University

Vascular oximetry system

A method for determining a hemoglobin saturation of a volume-oscillating vascular compartment in tissue includes receiving data representing measurements of a number of oscillating hemoglobin concentrations from the tissue and determining the hemoglobin saturation of the volume-oscillating vascular compartment to exclude an effect of an oscillating rate of supply of... Tufts University

Methods and compositions for inhibiting clostridium difficile spore germination and outgrowth

Certain bile acids, including novel bile acids, and derivatives thereof can be used to inhibit the germination of C. difficile spores and/or the growth of C. difficile cells. The methods and compositions of the invention are useful for preventing and treating C. difficile-associated diseases, including but not limited to C.... Tufts University

Methods and transformation of naturally competent cells

The present invention includes compositions and methods of co-transformation of naturally competent cells. In one aspect of the invention, a method is included for introducing nucleic acid sequences into one or more naturally competent cells in parallel. In other aspects, a heterogenic pool of co-transformed naturally competent cells and an... Tufts University

Silk-based scaffold platform for engineering tissue constructs

The inventions provided herein relate to silk-based scaffolds and methods of producing the same, which can be used for a range of tissue engineering applications. The fabrication methods described herein provide a versatile platform to incorporate hollow conduits (e.g., for nutrient/oxygen delivery) through three-dimensional silk-based scaffolds that have tunable bulk... Tufts University

Cupric oxide semiconductors

A method of preparing a cupric oxide semiconductor. The method includes providing a substrate having a first surface, forming a cuprous oxide layer on the first surface, converting the cuprous oxide layer into a cupric oxide layer via an oxidation reaction, and depositing additional cupric oxide on the cupric oxide... Tufts University








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