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Tufts University patents


Recent patent applications related to Tufts University. Tufts University is listed as an Agent/Assignee. Note: Tufts University may have other listings under different names/spellings. We're not affiliated with Tufts University, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "T" | Tufts University-related inventors


Fabrication of macroporous monodisperse hydrogel microspheres

A macroporous polymeric hydrogel microsphere that contains poly(ethylene glycol), chitosan, and water. The hydrogel microsphere, having a diameter of 50-250 gm and a mesh size of 5-100 nm, is capable of transporting biomolecules conjugated to it. ... Tufts University

Uridine monophosphate and triphosphate derivatives, compositions and methods of use

This disclosure relates to uridine nucleoside derivatives, compositions comprising therapeutically effective amounts of those nucleoside derivatives and methods of using those nucleoside derivatives or compositions in treating disorders that are responsive to compounds, such as agonists, of p2y6 receptor, e.g., neuronal disorders, including neurodegenerative disorders (e.g., alzheimer's disease, parkinson's disease) and traumatic cns injury, pain, down syndrome (ds), glaucoma and inflammatory conditions.. . ... Tufts University

Compositions and methods for treating inflammatory diseases

The invention provides compositions and methods for treating inflammatory diseases, such as cardiac or hepatic inflammatory diseases, involving the use of parasite-derived neurotrophic factor (pdnf), or fragment of pdnf.. . ... Tufts University

Shape memory silk materials

The present application relates to silk fibroin-based materials, methods for making and using the same. Provided materials exhibit shape memory characteristics while showing comparable or better volumetric swelling, biocompatibility and/or degradability when compared to current memory polymers derived from either natural or synthetic materials.. ... Tufts University

Non-neuroinvasive viruses and uses thereof

Provided herein are compositions and methods for vaccination and research applications. In particular, provided herein are non-neuroinvasive herpesviruses and alpha herpesviruses and uses thereof.. ... Tufts University

Two-layer nanofiltration membranes

A two-layer membrane including a polymer layer and a support layer, the polymer layer being disposed on a surface of the support layer. The polymer layer, having a pore size of at most 50 nm and a thickness of 5 nm to 10 μm, is formed of an amphiphilic copolymer that contains both charged groups and hydrophobic groups. ... Tufts University

Zwitterionic copolymers for fouling resistant filtration membranes

A graft copolymer including zwitterionic repeat units and hydrophobic repeat units, in which the zwitterionic repeat units constitute 2-60 wt % of the graft copolymer and each of the hydrophobic repeat units is characterized in that a homopolymer formed thereof is miscible with polyvinylidene fluoride, polysulfone, poly ether sulfone, polyvinyl chloride, or polyacrylonitrile, each of the hydrophobic repeat units not being a repeat unit of polyvinylidene fluoride. Also disclosed is a filtration membrane containing such a graft copolymer or a statistical copolymer that includes the same composition of repeat units as the graft copolymer. ... Tufts University

Maximum entropy quantization of link state

An approach to communication of a quantized value includes communicating one or more parameters characterizing a distribution of the values, and then repeatedly quantizing values according to the distribution and communicating the transmitted values. In some examples, the quantizing of the values is according to a maximum-entropy codebook determined from the distribution (or from the parameters characterizing the distribution). ... Tufts University

Vhh based binding antibodies for anthrax and botulinum toxins and methods of making and using therefor

Methods, compositions and kits are provided for treating a subject exposed to or at risk for exposure to a disease agent, methods, compositions and kits having a pharmaceutical composition including at least one recombinant binding protein or a source of expression of the binding protein, wherein the binding protein neutralizes at least one or a plurality of disease agents that are toxins, for example at least one of a botulinum toxin or an anthrax toxin.. . ... Tufts University

Drifting keyboard

A keyboard entry system for use in a touch screen display in which a user touches the display to move a keyboard on the display. The user moves the keyboard until a desired key lies under a fixed cursor. ... Tufts University

Three dimensional printing of bio-ink compositions

3d printing of biopolymer-based inks provides for manufacturing a broad range of products with desirable properties. A print nozzle may be charged to form a cone-shaped ink droplet to result in increased resolution, more reliable contact with irregular surfaces, and a mechanism to control contacting the ink to the print surface.. ... Tufts University

Compositions, methods and kits for treating complement related disorders

Compositions, methods and kits are provided for treating complement related disorders in a subject with protein in combination having protein fusions of at least two of a cd46 protein, a cd55 protein and a cd59 protein or with a recombinant chimeric protein having at least two of a cd46 protein, a cd55 protein and a cd59 protein or with nucleic acids encoding these proteins. The composition negatively modulates classical and alternative complement pathways thereby treating complement related disorder such as macular degeneration, age-related macular degeneration, diabetic retinopathy, inflammatory bowel disease, thyroiditis, cryoglobulinaemia, fetal loss, organ graft rejection, cancer, etc.. ... Tufts University

Lymphangiogenesis inhibitors for cancer and for graft survival

Compositions and methods are provided for treating and/or preventing lymphangiogenesis in a subject by using an inhibitor of a galectin-8 protein in an amount effective to inhibit or to modulate an activity of the galectin-8 protein or a portion thereof sufficient to inhibit the lymphangiogenesis associated with cancer, corneal injury, dry eye disease, inflammation, lymphedema, organ rejection or graft rejection.. . ... Tufts University

3d graphene transistor

A field effect transistor having a channel that comprises three-dimensional graphene foam. The subject matter of the invention concerns a three dimensional field-effect transistor having a channel based on graphene foam and the use of ionic liquid as a gate. ... Tufts University

06/22/17 / #20170179121

Integrated circuit with multi-threshold bulk finfets

A method for manufacturing a finfet having a fm that has a fm body includes selecting a desired electrical performance parameter, selecting a base dimension of the fin, identifying a combination of fin-body doping and fin-geometry that causes the finfet to have the desired electrical performance parameter, doping the fin body according to the identified fin-body doping, and fabricating the fm according to the fin-geometry.. . ... Tufts University

06/22/17 / #20170172417

System and method for measuring phase delay and amplitude of a near infra-red signal in animal tissue

A system and method, for measuring phase delay and amplitude of a near infrared signal emanating from tissue of an animal subject in response a near infrared signal input to such tissue, operate by processing a signal from an optical detector and a corresponding signal from an optical detector emulation circuit. In some aspects, the processed signals are fed into zero crossing detectors that in turn feed a time-to-digital converter providing at an output thereof a digital measure of the phase delay of the received optical signal.. ... Tufts University

06/08/17 / #20170156356

Biopolymer-based preservation of perishable products

Disclosed herein are biopolymer-based coatings and products incorporating such coatings. Related methods and use are also provided.. ... Tufts University

04/27/17 / #20170116971

Synthesizer with cymbal actuator

An apparatus for making music includes a cymbal, an acoustic transducer, a signal-processing system that receives a first signal from the acoustic transducer and that generates a second signal based on a property of the first signal, and a classifier that determines a particular manner in which the cymbal was struck based on the second signal, and provides an output trigger signal for triggering production of a sound that consistent with the particular manner.. . ... Tufts University

03/09/17 / #20170068777

Methods of identifying and formulating food compounds that modulate phenotype-related targets

This invention relates generally to (but is not limited to) identifying food compounds that have an impact on a phenotype of interest in a subject, and more particularly to identifying a phenotype-related target, identifying a stimulus (e.g., a pharmaceutical agent) that modulates that target, and identifying food compounds exhibiting similarity to the agent (e.g., having a chemical structure that is similar to the agent's structure). The similarity can be determined, for example, by a computer-interfaced comparison between a drug database and a food database.. ... Tufts University

03/02/17 / #20170056419

Methods and compositions for inhibiting clostridium difficile spore germination and outgrowth

Certain bile acids, including novel bile acids, and derivatives thereof can be used to inhibit the germination of c. Difficile spores and/or the growth of c. ... Tufts University

03/02/17 / #20170055893

Vascular oximetry system

A method for determining a hemoglobin saturation of a volume-oscillating vascular compartment in tissue includes receiving data representing measurements of a number of oscillating hemoglobin concentrations from the tissue and determining the hemoglobin saturation of the volume-oscillating vascular compartment to exclude an effect of an oscillating rate of supply of oxygenated blood to a portion of the tissue including removing a first contribution on one or more of the oscillating hemoglobin concentration measurements from at least one of the measurements, the first contribution being phase offset relative to said measurements.. . ... Tufts University

02/23/17 / #20170051311

Methods and apparatus for transformation of naturally competent cells

The present invention includes compositions and methods of co-transformation of naturally competent cells. In one aspect of the invention, a method is included for introducing nucleic acid sequences into one or more naturally competent cells in parallel. ... Tufts University

02/02/17 / #20170027879

Silk-based scaffold platform for engineering tissue constructs

The inventions provided herein relate to silk-based scaffolds and methods of producing the same, which can be used for a range of tissue engineering applications. The fabrication methods described herein provide a versatile platform to incorporate hollow conduits (e.g., for nutrient/oxygen delivery) through three-dimensional silk-based scaffolds that have tunable bulk properties (e.g., but not limited to, porosity, mechanical, degradation rate) and allow endothelialization and/or cell compartmentalization, for engineering a variety of complex tissue equivalents.. ... Tufts University

01/26/17 / #20170025555

Cupric oxide semiconductors

A method of preparing a cupric oxide semiconductor. The method includes providing a substrate having a first surface, forming a cuprous oxide layer on the first surface, converting the cuprous oxide layer into a cupric oxide layer via an oxidation reaction, and depositing additional cupric oxide on the cupric oxide layer, which serves as a seed layer, to yield a cupric oxide film, thereby obtaining a cupric oxide semiconductor. ... Tufts University








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