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Ucb Biopharma Sprl patents


Recent patent applications related to Ucb Biopharma Sprl. Ucb Biopharma Sprl is listed as an Agent/Assignee. Note: Ucb Biopharma Sprl may have other listings under different names/spellings. We're not affiliated with Ucb Biopharma Sprl, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "U" | Ucb Biopharma Sprl-related inventors


Antibodies

The present invention relates to an anti-csf-1r antibody and binding fragments thereof, dna encoding the same, host cells comprising said dna and methods of expressing the antibody or binding fragment in a host cell. The present invention also extends to pharmaceutical compositions comprising the antibody or a binding fragment thereof and use of the antibody, binding fragment and compositions comprising the same in treatment.. ... Ucb Biopharma Sprl

Method for increasing the percentage of monomeric antibody fab-dsfv multimeric species

The present invention provides method for increasing the percentage of monomer in a composition of recombinantly expressed antibody molecules characterised in that the antibody molecule comprises at least one fv with specificity for an antigen of interest comprising one vh and one vl wherein said vh and vl are connected directly or indirectly via one or more linkers and are stabilised by a disulfide bond therebetween, said method comprises a) a thermal conversion step of holding the composition comprising the antibody molecule at a temperature in the range 30 to 60° c. For a period of at least 1 hour, wherein step a) is performed in the presence of a reducing agent or after treatment with a reducing agent.. ... Ucb Biopharma Sprl

Method for the treatment of neurological disease

The present invention pertain an inhibitor of csf-1r activity for use in the treatment and/or prophylaxis of neurologic diseases and new method of treatment of neurologic diseases.. . ... Ucb Biopharma Sprl

Albumin binding antibodies and binding fragments thereof

A serum albumin binding antibody or fragment thereof comprising a heavy chain variable domain having the sequence given in seq id no: 1 or seq id no:2 and/or comprising a light chain variable domain having the sequence given in seq id no:3 or seq id no:4, in particular comprising a heavy chain variable domain and a light chain variable domain having the sequence given in seq id no: 1 and seq id no:3 or a heavy chain variable domain and a light chain variable domain having the sequence given in seq id no: 2 and seq id no:4. The disclosure also extends to polynucleotides encoding the antibodies or fragments, vectors comprising same and host cells capable of expressing the polynucleotides. ... Ucb Biopharma Sprl

Benzoxazinone derivatives and analogues thereof as modulators of tnf activity

A series of substituted 3,4-di-hydro-2h-.1,4-benzoxazin-3-one derivatives, and analogues thereof, being potent modulators of human tnfα activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.. . ... Ucb Biopharma Sprl

Anti-fcrn antibodies

The disclosure relates to antibody fusion proteins specific to fcrn, formulations comprising the same, use of each in therapy, processes for expressing and optionally formulating said antibody, dna encoding the antibodies and hosts comprising said dna.. . ... Ucb Biopharma Sprl

Method of monomerisation of recombinant antibody molecules

The present invention provides method of increasing the percentage of monomer in a composition of recombinantly expressed antibody molecules characterised in that the antibody molecule comprises at least one fv with specificity for an antigen of interest comprising one vh and one vl wherein said vh and vl are connected directly or indirectly via one or more linkers and are stabilised by a disulfide bond therebetween, said method comprises: a) a conversion step of treating the composition with a denaturant selected from urea and/or guanidine hydrochloride; b) wherein step a) is performed in the presence of a reducing agent or after treatment with a reducing agent.. . ... Ucb Biopharma Sprl

Auto-injector

Provided is a cassette unit suitable for use with an auto-injector having a drive unit. The cassette unit comprises a cassette unit housing defining a cassette unit housing cavity arranged for receipt of a syringe; a needle projection aperture; a needle cover defining a needle sheath for sheathing of a needle tip of the syringe; a removable cap that in a capping position fits over and thereby, acts such as to close off, the needle projection aperture, the removable cap defining a cap interior; provided to the removable cap, a cap insert; and provided to the cap insert, a connector defining one or more needle cover gripping elements for gripping the needle cover and the connector defines a central hub and the one or more needle gripper elements attach to the central hub and in spaced arrangement relative to each other, wherein the connector locates within the removable cap such that the central hub of the connector is in spaced relationship with a forward end wall or surface of the cap interior and the needle cover gripping elements project away from the forward end cap wall or surface of the cap interior and towards the open end of the cap, and wherein the removable cap is shaped to allow for limited axial travel of the cap insert there within.. ... Ucb Biopharma Sprl

Method for protein purification

The present invention provides a method for recovering a human vh3 domain-containing antibody in monomeric form. In particular the present invention provides a new method that allows recovery of monomeric human vh3 domain-containing antibodies from a mixture containing monomeric and multimeric forms of the antibody.. ... Ucb Biopharma Sprl

Auto-injector and drive unit therefor

Provided is a drive unit for an auto-injector having a drive unit housing arranged for docking receipt of a syringe or of a cassette unit comprising a syringe movable from a rest position, in which a needle tip of the syringe is within the drive unit housing to a use position, in which the needle tip protrudes from a needle delivery aperture; and a drive arrangement including one or more electrically powered sources of axial drive; a first drive transfer element for advancing the syringe to said use position; and a second drive transfer element for moving a plunger into the barrel of the syringe to eject liquid contents thereof. The drive unit housing is provided with a skin sensor arrangement having an array of plural skin sensor electrodes located about the needle delivery aperture.. ... Ucb Biopharma Sprl

A specific trifluoroethyl quinoline analogue for use in the treatment of sjögren's syndrome

N-{(r)-1-[8-chloro-2-(1-oxypyridin-3-yl)-quinolin-3-yl]-2,2,2-trifluoroethyl}-pyrido[3,2-d]pyrimidin-4-ylamine is effective in the treatment and/or prevention of sjögren's syndrome.. . ... Ucb Biopharma Sprl

Systems and methods for administering medication

The syringe systems disclosed herein provide in part devices for allowing patients with compromised joint strength to more easily administer medicine. Certain exemplary syringe embodiments include a handle forming a handgrip, a syringe barrel that magnifies the dosage marks located on an inner barrel, and a tip cap slidably engageable with the syringe barrel for shielding a needle.. ... Ucb Biopharma Sprl

Method of generating, storing and mining data related to key opinion leaders in scientific fields and computer system configured for presenting an explorable graphical user interface

A method of storing and ingesting data related to key opinion leaders is provided. The method includes extracting published works data, individual data, organization data and subject matter data for a plurality of published scientific works to identify entities for each of the published scientific works and storing the published works data, the individual data, the organization data and the subject matter data in a graph database as an explorable network in which each of the entities is represented by a respective node, the published scientific works including at least one of results of clinical trials and biomedical scientific publications, the entities including the published scientific works, individuals, organizations and subjects, the nodes including published work nodes representing the published scientific works, individual nodes representing the individuals, organization nodes representing the organizations and subject matter nodes representing the subjects, each of the individual nodes being linked to at least one of the other individual nodes, at least one of the organization nodes and at least one of the subject matter nodes, the graph database being configured such that the individual nodes, organization nodes and subject nodes are each displayable on a graphical user interface as a center node icon in a partial view of the explorable network with linked nodes being generated as outer node icons surrounding the center node icon. ... Ucb Biopharma Sprl

Polymeric fc proteins and methods of screening to alter their functional characteristics

The invention relates to polymeric fc proteins which bind to human fc-receptors and methods of screening said polymeric fc proteins to alter their functional characteristics. The invention also relates to therapeutic compositions comprising the polymeric fc proteins, and their use in the treatment of immune disorders.. ... Ucb Biopharma Sprl

02/15/18 / #20180043097

Auto-injector and drive unit therefor

Provided is a drive unit for an auto-injector having a drive unit housing arranged for docking receipt of a syringe or of a cassette unit comprising a syringe movable from a rest position, in which a needle tip of the syringe is within the drive unit housing to a use position, in which the needle tip protrudes from a needle delivery aperture; and a drive arrangement including one or more electrically powered sources of axial drive; a first drive transfer element for advancing the syringe to said use position; and a second drive transfer element for moving a plunger into the barrel of the syringe to eject liquid contents thereof. The drive unit housing is provided with a skin sensor arrangement having an array of plural skin sensor electrodes located about the needle delivery aperture.. ... Ucb Biopharma Sprl

02/08/18 / #20180037646

Epitopes of il-17a and il-17f and antibodies specific thereto

The present invention relates neutralising epitopes of il-17a and il-17f and antibodies which bind those epitopes. The present invention also relates to the therapeutic uses of the antibody molecules and methods for producing them.. ... Ucb Biopharma Sprl

02/01/18 / #20180028652

Pharmaceutical formulation

The current invention relates to a new pharmaceutical formulation, in particular to a pharmaceutical formulation comprising a protein, more particularly an antibody as an active ingredient.. . ... Ucb Biopharma Sprl

01/25/18 / #20180022812

Treatment of autoimmune disorders with cd154 antibodies

The present invention relates to a method of treating an autoimmune or inflammatory disease or a neurodegenerative disease with an antibody to cd154.. . ... Ucb Biopharma Sprl

01/25/18 / #20180022748

9h-pyrrolo-dipyridine derivatives

The invention relates to 9h-pyrrolo-dipyridine derivatives of formula i, processes for preparing them, pharmaceutical compositions containing them and their use as radiopharmaceuticals in particular as imaging agents for the detection of tau aggregates.. . ... Ucb Biopharma Sprl

01/25/18 / #20180021307

Combination treatment

The present invention relates and the combination of lacosamide and brivaracetam for the preparation of a fixed dose combination that is useful in the treatment of epilepsy, epileptogenesis, seizure disorders and convulsions.. . ... Ucb Biopharma Sprl

12/21/17 / #20170362272

Protein manufacture

The present invention provides a novel method for protein manufacture wherein the protein is expressed in a host cell, and in a more specific manner relates to a method for manufacturing a protein that results in reduced levels of product-related impurities.. . ... Ucb Biopharma Sprl

11/30/17 / #20170342105

Method of protein manufacture

The present invention provides a novel method for manufacturing a protein, particularly where said protein is to be coupled with another molecule. The invention further provides a method for industrial scale protein manufacturing to obtain proteins, e.g., for therapeutic purposes.. ... Ucb Biopharma Sprl

10/26/17 / #20170304292

Tetrahydroisoquinoline derivatives

The present invention relates to tetrahydroisoquinoline derivatives according to formula (i), which are positive allosteric modulators of d1 and accordingly of benefit as pharmaceutical agents for the treatment of diseases in which d1 receptors play a role.. . ... Ucb Biopharma Sprl

09/28/17 / #20170275355

Neutralising antibody molecules having specificity for human il-17

The invention relates to an antibody molecule having specificity for antigenic determinants of il-17, therapeutic uses of the antibody molecule and methods for producing said antibody molecule.. . ... Ucb Biopharma Sprl

08/24/17 / #20170242959

Method and system for quantifying the likelihood that a gene is casually linked to a disease

A computer program product, disposed on a non-transitory computer readable media, for analyzing a biological relevance of a candidate gene to a human phenotype is provided. The product includes computer executable process steps operable to control a computer to receive an input phenotype comprised of a plurality of input human traits and at least one input candidate gene; identify a plurality of disease-linked genes by querying disease-linked gene data and identifying genes causally linked to at least one disease; provide values of a semantic similarity metric for a identified gene set with respect to the input phenotype based on a comparison of human traits linked to each gene of the identified gene set and the input human traits, the identified gene set including genes mechanistically related to the input candidate gene that are included in the identified disease-linked genes; and output a statistical measure indicating whether the values of the semantic similarity metric of the genes of the identified gene set with respect to the input phenotype are greater than the values of the semantic similarity metric of others of the identified disease-linked genes with respect to the input phenotype by a statistically significant amount.. ... Ucb Biopharma Sprl

07/20/17 / #20170204200

Multispecific antibody constructs

The present disclosure relates to a multi-specific antibody molecule comprising or consisting of: a) a polypeptide chain of formula (i): vh—ch1—x—v1; and b) a polypeptide chain of formula (ii): vl-cl-y—v2 and pharmaceutical formulations comprising, for example for use in treatment. The disclosure also provides polynucleotide sequences encoding said multispecific antibody molecules, vectors comprising the polynucleotides and host cells comprising said vectors and/or polynucleotide sequences. ... Ucb Biopharma Sprl

07/20/17 / #20170204183

Molecules with specificity for cd45 and cd79

The present disclosure relates to a multispecific molecule comprising a binding domain specific to the antigen cd45 and a binding domain specific to the antigen cd79a and/or cd79b, compositions comprising same and use of each in treatment, for example treatment of autoimmune disease.. . ... Ucb Biopharma Sprl

07/20/17 / #20170204178

Molecules with specificity for cd79 and cd22

The present disclosure relates to multispecific molecule comprising a binding domain specific to the antigen cd22 and a binding domain specific to the antigen cd79a and/or cd79b, compositions comprising the same and use of both in treatment, for example the treatment of autoimmune disease.. . ... Ucb Biopharma Sprl

06/08/17 / #20170158688

Imidazopyridine derivatives as modulators of tnf activity

A series of substituted 1h imidazo[4,5-c]pyridine derivatives of formula (i), being potent modulators of human tnfa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.. . ... Ucb Biopharma Sprl

06/01/17 / #20170153244

Method for determining antibody specificity

The present invention relates to a method for determining antibody specificity, whether a multivalent antibody is monospecific, particularly whether a bivalent antibody is monospecific or bispecific. Furthermore the invention provides a method for quantifying the amount of bispecific bivalent antibody present in a sample.. ... Ucb Biopharma Sprl

05/18/17 / #20170140118

Method and system for generating and visually displaying inter-relativity between topics of a healthcare treatment taxonomy

A computerized method for displaying categorized healthcare textual data after a taxonomy has been applied to a data set is provided. The method includes generating a visual network generator graphical user interface configured to display a visual network comprised of a plurality of nodes and links, each of the nodes corresponding to a healthcare treatment topic, each of the links connecting two of the nodes; receiving a nodes input delimiting a number of the nodes to be displayed in the visual network; receiving at least one links input delimiting the links to be displayed in the visual network, the at least one links input including a first link input delimiting the links based on a modifiable metric representing a mixture of a first metric and a second metric, the first metric indicating a strength of potential links of each of the topics represented by one of the delimited nodes in the data set with each of the topics represented by the other delimited nodes of the data set, the second metric indicating a strength of each of the potential links of the delimited nodes in comparison to other potential links of the two respective delimited nodes each of the potential links is connecting; and generating, in response to the nodes input and the at least one links input, the delimited nodes and the delimited links in the visual network on the visual network generator graphical user interface to illustrate correlations between the healthcare treatment topics of different categories.. ... Ucb Biopharma Sprl

05/18/17 / #20170140117

Method and system for generating and displaying topics in raw uncategorized data and for categorizing such data

A computerized method for searching and organizing a healthcare textual data set is provided. The method includes receiving, by a server including a processor and a memory, an input of a user of a selected healthcare treatment product delimiting a subject data set; displaying, in response to the input subject data set received by the server, an intertopic distance map on a topic modeler graphical user interface displaying topics of the input subject data set as raw uncategorized data, the topic modeler graphical user interface displaying icons each representing a corresponding topic within the data set, the icons illustrating a prevalence of the topics in the data set by sizes of the icons and an interrelatedness of the topics by spacing and/or overlap of the icons; modifying, in response to a selection of one of the icons, a terms graph of the topic modeler graphical user interface to display representative keywords of the topic represented by the selected icon; receiving an input of a pattern in a taxonomy modifier graphical user interface generated by the server; displaying, in response to the input pattern, text of the data set corresponding to the input pattern on the taxonomy modifier graphical user interface; and adding, in response to a request of the user, the input pattern to one or more existing levels of a taxonomy of the data set to alter the structure of the taxonomy and provide a modified healthcare treatment taxonomy on the memory of the server.. ... Ucb Biopharma Sprl

05/18/17 / #20170140110

Method and system for generating and displaying structured topics of a healthcare treatment taxonomy in different formats

A computerized method for generating and displaying structured topics of a taxonomy in different formats is provided. The computerized method includes generating a categorized topic viewer graphical user interface allowing a user to select a textual model defining a corpus of documents to explore by delimiting a healthcare treatment product; generating in the categorized topic viewer graphical user interface, in response to an input of the user delimiting the healthcare treatment product, at least one of a plurality of tools; generating in a topic mapping graphical user interface an interactive map illustrating the number of documents for a first class for each corresponding country; generating in a trend generating graphical user interface at least one of a plurality of tools; and modifying each of the categorized topic viewer graphical user interface, the topic mapping graphical user interface and the trend generating graphical user interface in response to at least one input of the user into at least one taxonomy filter such that data displayed by each of the categorized topic viewer graphical user interface, the topic mapping graphical user interface and the trend generating graphical user interface display data related to a second class of the corpus of documents, the second class being a subcategory of the first class.. ... Ucb Biopharma Sprl

05/11/17 / #20170129894

Triazolopyridazine derivatives as modulators of tnf activity

A series of substituted [1,2,4]triazolo[4,3-b]pyridazine derivatives of formula (i), being potent modulators of human tnfa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.. . ... Ucb Biopharma Sprl

05/11/17 / #20170129883

Tetrahydroimidazopyridine derivatives as modulators of tnf activity

A series of substituted 4,5,6,7-tetrahydro-1h-imidazo[4,5-c]pyridine derivatives, being potent treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.. . ... Ucb Biopharma Sprl

05/11/17 / #20170128445

Fused imidazole and pyrazole derivatives as modulators of tnf activity

A series of substituted benzimidazole, imidazo[1,2-α]pyridine and pyrazolo[1,5-α]pyridine derivatives, and analogues thereof, being potent modulators of human tnfα activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.. . ... Ucb Biopharma Sprl

04/20/17 / #20170105988

Pharmaceutical compositions comprising levocetirizine

The present invention relates to a pharmaceutical composition comprising levocetirizine. The invention relates specifically to a dry syrup formulation.. ... Ucb Biopharma Sprl

03/30/17 / #20170088603

Multimeric fc proteins

The invention relates to multimeric fusion proteins which bind to human fc receptors. The invention also relates to therapeutic compositions comprising the proteins, and their use in the treatment of immune disorders.. ... Ucb Biopharma Sprl

03/23/17 / #20170081406

Multimeric fc proteins

The invention relates to multimeric fusion proteins which bind to human fc receptors. The invention also relates to therapeutic compositions comprising the proteins, and their use in the treatment of immune disorders.. ... Ucb Biopharma Sprl

03/23/17 / #20170081404

New bispecific format suitable for use in high-through-put screening

The present disclosure relates to a novel bispecific protein complex and a method of using the complexes to screen for synergistic or novel biological function. The bispecific format is particularly suitable for high-throughput screening because all of its components can be expressed from cells as individual units and the units can be assembled simply by mixing without employing conjugation or coupling chemistry.. ... Ucb Biopharma Sprl

03/23/17 / #20170081321

Pyrazolopyridine derivatives as modulators of tnf activity

A series of substituted pyrazolo[1,5-a]pyridine derivatives, being potent modulators of human tnfα activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.. . ... Ucb Biopharma Sprl

02/02/17 / #20170029505

Multimeric fc proteins

The invention relates to multimeric proteins which bind to human fc receptors. The invention also relates to therapeutic compositions comprising the proteins, and their use in the treatment of immune and other disorders.. ... Ucb Biopharma Sprl

01/12/17 / #20170007763

Auto-injector

Provided is a cassette unit suitable for use with an auto-injector having a drive unit. The cassette unit comprises a cassette unit housing defining a cassette unit housing cavity, which is in receipt of a syringe, a rearward entrance to said cavity and a forward needle projection aperture. ... Ucb Biopharma Sprl

01/05/17 / #20170002378

Synthetic promoters

Cho cell-specific synthetic promoter constructs for expressing recombinant proteins, a library of promoter constructs thereof, and a method for producing the promoter constructs. The promoter constructs enable precise control of recombinant gene transcription over three orders of magnitude, with the top expressing promoters capable of double the transcriptional activity of the cmv promoter.. ... Ucb Biopharma Sprl

01/05/17 / #20170000955

Auto-injector

Provided is a cassette unit suitable for use with an auto-injector having a drive unit. The cassette unit comprises a cassette unit housing defining a cassette unit housing cavity arranged for receipt of a syringe; a needle projection aperture; a needle cover defining a needle sheath for sheathing of a needle tip of the syringe; a removable cap that in a capping position fits over and thereby, acts such as to close off, the needle projection aperture, the removable cap defining a cap interior; provided to the removable cap, a cap insert; and provided to the cap insert, a connector defining one or more needle cover gripping elements for gripping the needle cover and the connector defines a central hub and the one or more needle gripper elements attach to the central hub and in spaced arrangement relative to each other. ... Ucb Biopharma Sprl








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