Universite Pierre Et Marie Curie patents

Method and device to assist with the operation of an instrument

The invention relates to a device and a method to assist with the operation of an instrument by means of said device, the device and the method using leverage effects in order to calculate the data relative to any point of an instrument axis, instead of using low-accuracy sensors. Other... Universite Pierre Et Marie Curie

Use of a reverse-transcriptase inhibitor in the prevention and treatment of degenerative diseases

The invention relates to the use of a reverse-transcriptase inhibitor in the prevention or treatment of a degenerative disease.... Universite Pierre Et Marie Curie

Tricyclo-dna antisense oligonucleotides, compositions, and methods for the treatment of disease

Provided are tricyclo-DNA (tc-DNA) AON and methods employing tc-DNA AON for modifying splicing events that occur during pre-mRNA processing. Tricyclo-DNA (tc-DNA) AON are described that may be used to facilitate exon skipping or to mask intronic silencer sequences and/or terminal stein-loop sequences during pre-mRNA processing and to target RNase-mediated destruction... Universite Pierre Et Marie Curie

Lentiviral vectors for regulated expression of a chimeric antigen receptor molecule

The invention relates to the regulated expression of a chimeric antigen receptor (CAR) within a lentiviral vector. The CAR comprises a hook-binding domain that interacts with a hook, preferably encoded by the same lentiviral vector, which prevents proper processing and release of the CAR to the cell membrane. The invention... Universite Pierre Et Marie Curie

Light unmanned vertical take-off aircraft

A light unmanned vertical take-off aircraft includes at least two fixed coplanar propulsion devices and at least one wing providing the lift for the drone. The coplanar propulsion devices and the wing are each laid out on the frame of the drone so that the plane of the profile chord... Universite Pierre Et Marie Curie

Prevention or treatment of an infection by bacteroides thetaiotaomicron

The present invention relates to a composition comprising a therapeutically effective amount of Bacteroides thetaiotaomicron or an extract thereof for use in the prevention or treatment of an infection in a subject who is immunodepressed, who is immunosuppressed, who has an immature immune system, and/or who has a weakness, and... Universite Pierre Et Marie Curie

Pixel cell circuit and implant

A pixel cell circuit comprises an electrode, one or more main photosensitive elements electrically coupled to the electrode for outputting a stimulation signal to the electrode responsive to light illumination, and a shunt arrangement comprising a shunt switch electrically coupled in parallel across the one or more photosensitive elements, and... Universite Pierre Et Marie Curie

Injectable collagen suspensions, the preparation method thereof, and the uses thereof, particularly for forming dense collagen matrices

Disclosed is the preparation of injectable collagen suspensions, to the method for preparing the suspensions, and to the uses thereof, particularly for forming dense collagen matrices.... Universite Pierre Et Marie Curie

Pro-apoptotic set and pp2a peptides

The invention provide chimeric peptides comprising a chimeric peptide comprising a cell-penetrating peptide linked to a pro-apoptotic peptide, wherein the pro-apoptotic peptide is derived from, or consists of, a portion of PP2A protein that binds a SET protein or is derived from, or consists of, a portion of the SET... Universite Pierre Et Marie Curie

Method for processing an asynchronous signal

Disclosed is a method for processing an asynchronous signal produced by a light sensor, the sensor having a pixel matrix disposed opposite a scene, the method including: receiving from the light sensor the asynchronous signal including, for each pixel of the matrix, successive events from the pixel; analysing the asynchronous... Universite Pierre Et Marie Curie

Method for the 3d reconstruction of a scene

The present invention concerns a method for the 3D reconstruction of a scene comprising the matching (610) of a first event from among the first asynchronous successive events of a first sensor with a second event from among the second asynchronous successive events of a second sensor depending on a... Universite Pierre Et Marie Curie

Method of diagnosis, prognosis or treatment of neurodegenerative diseases

Methods for the diagnosis and prognosis of neurodegenerative diseases, such as a Tauopathy or Alzheimer's disease, are described. Compositions and methods for the treatment of neurodegenerative diseases are also described.... Universite Pierre Et Marie Curie

Interstitial ultrasonic disposable applicator and tissue thermal conformal volume ablation and monitoring the same

An interstitial ultrasound thermal ablation applicator for conformal treatment of an inhomogeneous tumor lesion includes: a body having a longitudinal axis; and a plurality of array transducers mounted on the body, arranged side by side and having azimuth directions parallel to the longitudinal axis of the body, and having outer... Universite Pierre Et Marie Curie

Method for inducing targeted meiotic recombinations

The present invention relates to a fusion protein comprising a Cas9 domain and a Spo11 domain, as well as the use of this protein to induce targeted meiotic recombinations in a eukaryotic cell.... Universite Pierre Et Marie Curie

Imaging device and method

Disclosed is an imaging device including a light source arranged so as to generate an optical signal, an optical support coupled to the light source and arranged so as to project a luminous excitation signal with a substantially constant light intensity, from the light source to a body to be... Universite Pierre Et Marie Curie

Treatment of facioscapulohumeral dystrophy

The present invention relates to nucleic acids, compositions and methods for the treatment of facioscapulohumeral dystrophy.... Universite Pierre Et Marie Curie

Bixa orellana composition for the treatment macular degeneration

A method for photoprotection of the retinal pigmentary epithelium in a mammal includes administering an effective amount of a composition containing an extract of seeds of Bixa orellana. A process for preparing the extract and formulations of the composition are also provided.... Universite Pierre Et Marie Curie

Transgenic rpe cells overexpressing otx2 for the treatment of retinal degeneration

The present invention relates to methods and composition for use in the treatment of retinal degeneration, in particular retinal degeneration due to retinal pigment epithelium dysfunction.... Universite Pierre Et Marie Curie

Aerosol-obtained mesostructured particles loaded with anticorrosion agents

The present invention relates to mesostructured particles that have the particular property of being spontaneously individualized, and that include anticorrosion agents. The invention also relates to a process for preparing these particles, and also to materials obtained by inclusion of these particles in matrices.... Universite Pierre Et Marie Curie

Methods and pharmaceutical compositions for treating human immunodeficiency virus type 1 (hiv-1) infections

The present invention provides methods and pharmaceutical compositions for treating human immunodeficiency virus type 1 (HIV-1) infections. In particular, the present invention relates to a method for treating HIV-1 infection in a subject in need thereof comprising administering the subject with a therapeutically effective amount of an inhibitor of SGT1... Universite Pierre Et Marie Curie

Anti-corrosion coatings loaded with mesostructured particles

Coatings, for example polymer coatings or sol-gel coatings, including at least one layer of micrometric, individualised and mesostructured spherical particles. The particles having been created and loaded with at least one element selected from corrosion-inhibiting functional molecules and corrosion-inhibiting functional nano-objects, by a method having non-dissociable nebulization-heating steps that are... Universite Pierre Et Marie Curie

Use of low dose il-2 for treating autoimmune – related or inflammatory disorders

The present invention relates to novel therapies for treating autoimmune and inflammatory diseases. More specifically, the present invention relates to a use of low dose interleukin-2 for the treatment of type I diabetes and other autoimmune and/or inflammatory diseases.... Universite Pierre Et Marie Curie

Method and device for estimating optical properties of a sample

A method and a device allow optical properties of a sample to be estimated. The method includes the illumination of the sample by a first light source, and the formation of an image of the sample thus illuminated, on the basis of which a first optical property is estimated, at... Universite Pierre Et Marie Curie

Active glazing system

An active glazing system (100) includes a double glazing, with two transparent plates (1a, 1b) that together delimit an intermediate volume (2) filled with gas. The system further includes a control device (10) that is capable of producing a transition in a volatile compound present in the intermediate volume, between... Universite Pierre Et Marie Curie

Pharmaceutical compositions for preventing glucocorticoid-induced corneal or skin thinning

The present invention relates to method and pharmaceutical compositions for preventing glucocorticoid-induced corneal or skin thinning. In particular, the present invention relates to a mineralocorticoid receptor antagonist for topical use in a method for preventing or reducing glucocorticoid-induced corneal or skin thinning in a subject in need thereof. The invention... Universite Pierre Et Marie Curie

Method for transiently disrupting a region of the blood-brain barrier of a human

The present invention relates to a method for transiently disrupting a region of the blood-brain barrier (BBB) of a human using ultrasounds in the presence of an ultrasound contrast agent, and uses thereof. The method comprises the application of at least one ultrasound (US) beam with a pressure level higher... Universite Pierre Et Marie Curie

Method for characterizing the cracking mechanism of a material from the fracture surface thereof

The disclosed method includes, from a topographic map showing, for a set of points {x} located in a midplane of the fracture surface, a height of the fracture surface h relative to the midplane: a step of determining, for each point x on the topographic map, a quantity ω∈ representative... Universite Pierre Et Marie Curie

Method for in vitro production of adipocyte progenitors and adipocytes

The present invention relates to a method for in vitro production of adipocyte progenitors and adipocytes from pluripotent stem cells, in particular from induced pluripotent stem cells, as well as to the use of the adipocyte progenitors and adipocytes thus obtained for therapeutic or screening purposes.... Universite Pierre Et Marie Curie

Cyclic compounds having a 1,3 diamino-functionality for use in the treatment of hiv infection

The present invention relates to compounds, capable of activating HIV expression in reservoir cells, of formula (I) for use in the treatment of HIV infection.... Universite Pierre Et Marie Curie

Optical device for measuring the position of an object

The invention relates to an optical device for measuring the position of an object along a first axis, the object being subjected to light radiations emitted by a light source. The optical device comprises: an imaging system comprising an objective for collecting light radiations diffused by the object, the imaging... Universite Pierre Et Marie Curie

Treatment of amyotrophic lateral sclerosis

The invention relates to a method for the treatment of amyotrophic lateral sclerosis (ALS). Specifically, the invention implements the use of an antisense sequence adapted to affect alternative splicing in a human SOD1 pre-mRNA, thereby leading to the destruction of the skipped m RNA by the cell machinery.... Universite Pierre Et Marie Curie

Display control for implementing said method

A method of controlling the display of images in the form of a pixel array, includes for a pixel of the array, asynchronous information representing events concerning the pixel is received, a first activation of the pixel is actuated at an activation time determined by a first event of the... Universite Pierre Et Marie Curie

Device for displaying an image sequence and system for displaying a scene

A device for displaying an image sequence in the form of a pixel matrix, includes a control unit coupled to a projector. The control unit includes an input interface designed to receive asynchronous information representing, for each pixel of the matrix, events concerning the pixel, and a processor designed to... Universite Pierre Et Marie Curie

Lentiviral-based vector and its use in directed evolution of genomic regions, genes and polynucleotides

Replication-defective lentiviral vectors are described. Using this vector, methods of directing evolution of a target polynucleotide of interest for obtaining variants of the target polynucleotide, methods to generate genetic variability by preparing a cell library, and methods to isolate and/or screen variants of a polynucleotide or variants of a protein... Universite Pierre Et Marie Curie

Method of dna sequencing by polymerisation

The present invention relates to a method for the determination of a nucleic acid sequence by physical manipulation. The method is based on the precise determination of the localization of the replicating fork on the template by measuring the physical distance between one end of the molecule and the fork.... Universite Pierre Et Marie Curie