Real Time Touch



new TOP 200 Companies filing patents this week

new Companies with the Most Patent Filings (2010+)




Real Time Touch

University Health Network patents


Recent patent applications related to University Health Network. University Health Network is listed as an Agent/Assignee. Note: University Health Network may have other listings under different names/spellings. We're not affiliated with University Health Network, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "U" | University Health Network-related inventors


Salt and crystal forms of plk-4 inhibitor

A fumarate salt and a maleate salt of compound (i) represented by the following structural formula, as well as their corresponding pharmaceutical compositions, are disclosed. Particular single crystalline forms of 1:1 compound (i) fumarate and 1:1 compound (i) maleate are characterized by a variety of properties and physical measurements. ... University Health Network

Nk cells and antibodies for cancer treatment

Treatment of cancer in a patient comprises administering to the patient an effective amount of an antibody and an effective amount of nk cells, wherein the antibody binds an antigen on the surface of the nk cells and the antibody binds to an fc receptor on a cell of the cancer. Anticancer activity is via resultant killing action of the nk cell on the cancer cell now binding the antibody via r-adcc.. ... University Health Network

Method and apparatus for the measurement, characterization and correction of geometric distortions in magnetic resonance imaging

Various embodiments are described herein for an apparatus and a method for measuring and characterizing geometric distortions for a region of interest in images obtained using magnetic resonance. The method comprises deriving a computed set of 3d distortion vectors for a set of points within a region of interest covered by a phantom by using harmonic analysis to solve an associated boundary value problem based on boundary conditions derived from a measured set of 3d distortion vectors. ... University Health Network

Method and system for assessing qrs components and the risk of ventricular arrhythmias

Various embodiments are described herein for a system and a method for assessing a risk of ventricular arrhythmias for a patient. For example, the method may comprise receiving ecg data obtained from the patient; analyzing the ecg data to detect abnormal qrs peaks; determining the risk of ventricular arrhythmias for the patient based on the detected abnormal qrs peaks; and providing an indication of the risk of ventricular arrhythmias for the patient. ... University Health Network

Synthesis of chiral 2-(1h-indazol-6-yl)-spiro[cyclopropane-1,3'-indolin]-2'-ones

The present invention is directed to novel synthetic methods for preparing cyclopropyl indolinone compound represented by structural formula (a): (a) or its pharmaceutically acceptable salt thereof. Also included are synthetic intermediates described herein.. ... University Health Network

Texaphyrin-phospholipid conjugates and methods of preparing same

There is provided herein, a texaphyrin-phospholipid conjugate, wherein the texaphyrin-phospholipid conjugate comprises a texaphyrin, texaphyrin derivative or texaphyrin analog covalently attached to a lipid side chain of a phospholipid.. . ... University Health Network

Method for expansion of double negative regulatory t cells

There is provided herein a method for expanding human cd4−cd8− regulatory t cells (dn tregs) from a population of cells comprising dn tregs, comprising: culturing the population of cells with artificial antigen presenting cells (apcs), prefer-ably the dn tregs are αβ-tcr−cd56− or alternatively γδ-tcr+.. . ... University Health Network

Method of inhibition of leukemic stem cells

A method for inhibition of leukemic stem cells expressing il-3rα (cd123), comprises contacting the cells with an antigen binding molecule comprising a fc region or a modified fc region having enhanced fc effector function, wherein the antigen binding molecule binds selectively to il-3rα (cd123). The invention includes the treatment of a hematologic cancer condition in a patient by administration to the patient of an effective amount of the antigen binding molecule.. ... University Health Network

Breathing disorder identification, characterization and diagnosis methods, devices and systems

Disclosed herein are breathing disorder identification, characterization and diagnosis methods, devices and systems. In general the disclosed methods, devices and systems may rely on the characterization of breath sound amplitudes, periodic breath sounds and/or aperiodic breath sounds to characterize a breathing disorder as obstructive (e.g. ... University Health Network

System and method for rotor detection in cardiac fibrillation

Various embodiments are described herein for detecting a rotor at a location of a heart that experiences cardiac fibrillation. This generally involves obtaining a plurality of bipolar egms for a recording duration using a circular bipolar electrode array positioned at the location of the heart; detecting a dominant periodicity cycle length (cl) and identifying periodic activations for each bipolar egm associated with the dominant periodicity cl; tracking the identified periodic activations across each bipolar egm to define rotational activations and determining when a path taken by the tracked rotational activations corresponds to a rotational activation pattern of a rotor; and detecting the rotor when a number and completeness of the tracked rotational activations meet predefined rotor criteria.. ... University Health Network

Methods for making and using sinoatrial node-like pacemaker cardiomyocytes and ventricular-like cardiomyocytes

Provided are methods for producing compositions comprising a population of cardiomyocytes enriched for or substantially devoid of sinoatrial node-like pacemaker cardiomyocytes (sanlcm) from human pluripotent stem cells (hpscs), and methods of use thereof.. . ... University Health Network

Methods and compositions for modulating toso activity

The present invention is further directed to methods and compositions for modulating the activity of the toso protein. The invention further encompasses treatment of disorders associated with inflammation, autoimmune disorders, and cancer using compositions that include a soluble toso protein.. ... University Health Network

Drug complexes comprising alpha-fetoprotein

Compositions which comprise a hydro-phobic taxane such as paclitaxel are produced by non-covalent complexing between the taxane and alpha-fetoprotein c at a ratio of about 4 moles of taxane per mole of afp. The complexes are water soluble and suitable for injection. ... University Health Network

System and method for enhanced mass spectrometry imaging

Various embodiments are described herein for a system and a method for identifying a region of interest in tissue using mass spectrometry. An agent administration component can be provided to administer an exogenous agent to the tissue. ... University Health Network

11/09/17 / #20170320881

Pyrazolopyrimidine compounds

The present teachings provide a compound represented by the following structural formula: (formula (i)); or a pharmaceutically acceptable salt thereof. Also described are pharmaceutical compositions and methods of use thereof.. ... University Health Network

11/09/17 / #20170319719

J-aggregate forming nanoparticle

There is provided herein a nanovesicle having a bilayer comprising a saturated first phospholipid and no more than about 15 molar % of a second phospholipid covalently conjugated to a j-aggregate forming dye.. . ... University Health Network

10/26/17 / #20170304648

Photodynamic compounds and methods for activating them using ionizing radiation and/or other electromagnetic radiation for therapy and/or diagnostics

A method for destroying cells and/or microorganisms in an organism includes the following steps: (a) administering to the organism a composition including a photodynamic compound containing at least one transition metal; and (b) irradiating the photodynamic compound in the organism with electromagnetic radiation, wherein the electromagnetic radiation includes ionizing radiation and is effective to activate the photodynamic compound to destroy at least one of the cells and the microorganisms in the organism. The ionizing radiation is preferably x-rays and/or gamma rays. ... University Health Network

09/28/17 / #20170274060

Immunotherapy for the treatment of cancer

Methods for the treatment of cancer using double negative (dn) t cells are described. The dnts may be used for the treatment of chemotherapy-resistant cancers such as recurring or relapsing acute myeloid leukemia (aml). ... University Health Network

09/21/17 / #20170269094

Organotellurium compounds, compositions and methods of use thereof

A compound of formula (i) as described herein and methods and uses thereof as probes in the mass tagging of biosensors or biologically active materials for use in mass cytometry analysis of tissue samples such as in the detection, labelling and quantification of oxygen-deprived cells by using, for example, tellurophene-tagged 2-nitroimidazole.. . ... University Health Network

09/21/17 / #20170267977

Organoids for drug screening and personalized medicine

There is provided herein cell culture mediums for generating organoids, including tumour organoids.. . ... University Health Network

09/07/17 / #20170252440

Multifunctional nanoparticle compositions and uses thereof

Disclosed herein are multifunctional nanoparticle compositions. The compositions can be useful for the treatment of cancer by enhancing the anti-tumor effectiveness of radiation directed to a tissue, cell or a tumor and the methods of use thereof. ... University Health Network

08/31/17 / #20170245807

Method for t1 mapping with incomplete tissue magnetization recovery

Methods and systems for performing t1 mapping. T1 samples are obtained from an acquisition including one or more inversion groupings. ... University Health Network

08/17/17 / #20170236281

Collection and analysis of data for diagnostic purposes

Systems and methods for determining bacterial load in targets and tracking changes in bacterial load of targets over time are disclosed. An autofluorescence detection and collection device includes a light source configured to directly illuminate at least a portion of a target and an area around the target with excitation light causing at least one biomarker in the illuminated target to fluoresce. ... University Health Network

08/10/17 / #20170226088

Synthesis of chiral 2-(1h-indazol-6-yl)-spiro[cyclopropane-1,3'-indolin]-2'-ones

The present invention is directed to novel synthetic methods for preparing cyclopropyl indolinone compound represented by structural formula (a): (a) or its pharmaceutically acceptable salt thereof. Also included are synthetic intermediates described herein.. ... University Health Network

08/03/17 / #20170217966

Pyrazolopyrimidine compounds

The present teachings provide a compound represented by structural formula (i-0), or a pharmaceutically acceptable salt thereof. Also described are pharmaceutical compositions and methods of use thereof.. ... University Health Network

06/22/17 / #20170175396

Connector apparatus

A locking member for a gate apparatus comprises a body mountable to a gripping array of a support, said body having a mating form mutually engageable with the gripping array, whereby axial motion of said body relative to said gripping array is inhibited. A member extends away from said body, said member defining a cross-tie mount for receiving a mating end of a cross-tie. ... University Health Network

06/22/17 / #20170172497

Method and system for brain activity signal-based treatment and/or control of user devices

A method for characterizing a brain electrical signal comprising forming a temporo-spectral decomposition of the signal to form a plurality of time resolved frequency signal values, associating each instance of the signal value with a predetermined function approximating a neurological signal to form a table of coefficients collectively representative of the brain electrical signal.. . ... University Health Network

05/18/17 / #20170136090

Angiopoietin-based interventions for treating cerebral malaria

The present invention provides methods for treating, preventing or reducing the severity of cerebral malaria. The methods of the present invention comprise administering to a subject in need thereof a therapeutically effective amount of a pharmaceutical composition comprising a modified angiopoietin molecule such as angf1-fc-f1.. ... University Health Network

05/18/17 / #20170136072

Il-12 immunotherapy for cancer

Compositions and methods far delivering immune modulatory molecules to result in a therapeutic effect are disclosed. The compositions and methods use stably integrating lentiviral delivery systems. ... University Health Network

05/11/17 / #20170128591

Peptide containing porphyrin lipid nanovesicles

There is provided herein a nanovesicle comprising a monolayer of phospholipid, porphyrin-phospholipid conjugate and a peptide encapsulating a hydrophobic core, wherein the peptide comprises an amino acid sequence capable of forming at least one amphipathic α-helix; the porphyrin-phospholipid conjugate comprises one porphyrin, porphyrin derivative or porphyrin analog covalently attached to a lipid side chain, preferably at the sn-1 or the sn-2 position, of one phospholipid; the molar % of porphyrin-phospholipid conjugate to phospholipid is 35% or less; the nanovesicle is 35 nm in diameter or less.. . ... University Health Network

05/04/17 / #20170121398

Anti-transthyretin antibodies

The invention provides antibodies that specifically bind to transthyretin (ttr). The antibodies can be used for treating or effecting prophylaxis of diseases or disorders associated with ttr accumulation or accumulation of ttr deposits (e.g., ttr amyloidosis). ... University Health Network

05/04/17 / #20170119303

Acoustic upper airway assessment system and method, and sleep apnea assessment system and method relying thereon

Described are various embodiments of an acoustic upper airway assessment system and method, and sleep apnea assessment system and method relying thereon. In one embodiment, a non-invasive method is described for assessing upper airway anatomy in a subject while breathing. ... University Health Network

04/13/17 / #20170100606

Fiber optic light delivery, monitoring and apparatus therefore

Apparatus for illuminating comprises one or more fibers, the one or more fibers including fiber portions meeting at an apex and a bottom location to form a three dimensional cage; a detector attached to each of the fiber portions for receiving light and transmitting light along each of the fiber portions, respectively; and an illumination member situated within the cage. A method for illuminating a hollow member includes the steps of inserting one or more fibers into the hollow member, wherein one or more fibers include fiber portions that meet at a location to form a three-dimensional cage; permitting light to emit from within the three-dimensional cage and towards the fiber portions; receiving light at distinct locations on each of said fibers; and allowing each of the fibers to transmit the light received on each of the fiber portions out of the hollow member.. ... University Health Network

03/30/17 / #20170089929

Antibodies to ttr and methods of use

The disclosure pertains to antibodies and binding fragments thereof that specifically binds all or part of ehaevvfta. Also provided are isolated peptides, isolated nucleic acids, immunogens, compositions, immunoassays and kits and method of using said reagents to detect misfolded ttr.. ... University Health Network

03/23/17 / #20170079539

System and method for focal source identification

Various embodiments are described herein for a system, method, and device for identifying focal source locations of electrophysiological activity in an organ. The system, method and device may also be used to guide catheter ablation of the organ. ... University Health Network

03/16/17 / #20170071983

Combination therapy with double negative t-cells

There is provided herein methods of treating leukemia or lymphoma in a subject in need thereof, with double negative t cells (dnts) in combination with interferon-γ.. . ... University Health Network

03/02/17 / #the application relates to a composition comprising:

University Health Network

. . ... University Health Network

03/02/17 / #20170058023

Anti-transthyretin antibodies

The invention provides antibodies that specifically bind transthyretin (ttr). The antibodies can be used for treating or effecting prophylaxis of diseases or disorders associated with ttr accumulation or accumulation of ttr deposits (e.g., ttr amyloidosis). ... University Health Network

02/09/17 / #20170036006

Cannula for connecting medical devices to biological systems

A cannula for connecting a medical device to a biological system is taught. The cannula includes a tissue engagement portion, preferably in the form of an annulus, to which a vacuum is applied through the cannula to attract and hold tissue of the biological system in an initial connection while an affixment device is applied to complete the connection. ... University Health Network

02/02/17 / #20170029515

Method of inhibition of leukemic stem cells

A method for inhibition of leukemic stem cells expressing il-3rα (cd123), comprises contacting the cells with an antigen binding molecule comprising a fc region or a modified fc region having enhanced fc effector function, wherein the antigen binding molecule binds selectively to il-3rα (cd123). The invention includes the treatment of a hematologic cancer condition in a patient by administration to the patient of an effective amount of the antigen binding molecule.. ... University Health Network

01/19/17 / #20170015737

Anti-transthyretin antibodies

The invention provides antibodies that specifically bind to transthyretin (ttr). The antibodies can be used for treating or effecting prophylaxis of diseases or disorders associated with ttr accumulation or accumulation of ttr deposits (e.g., ttr amyloidosis). ... University Health Network








ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009



###

This listing is an abstract for educational and research purposes is only meant as a recent sample of applications filed, not a comprehensive history. Freshpatents.com is not affiliated or associated with University Health Network in any way and there may be associated servicemarks. This data is also published to the public by the USPTO and available for free on their website. Note that there may be alternative spellings for University Health Network with additional patents listed. Browse our Agent directory for other possible listings. Page by FreshPatents.com

###