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University Health Network patents


Recent patent applications related to University Health Network. University Health Network is listed as an Agent/Assignee. Note: University Health Network may have other listings under different names/spellings. We're not affiliated with University Health Network, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "U" | University Health Network-related inventors


 new patent  Drug complexes comprising alpha-fetoprotein

Compositions which comprise a hydro-phobic taxane such as paclitaxel are produced by non-covalent complexing between the taxane and alpha-fetoprotein c at a ratio of about 4 moles of taxane per mole of AFP. The complexes are water soluble and suitable for injection. Uses of the compositions for treating a subject... University Health Network

 new patent  Methods and compositions for modulating toso activity

The present invention is further directed to methods and compositions for modulating the activity of the Toso protein. The invention further encompasses treatment of disorders associated with inflammation, autoimmune disorders, and cancer using compositions that include a soluble Toso protein.... University Health Network

System and enhanced mass spectrometry imaging

Various embodiments are described herein for a system and a method for identifying a region of interest in tissue using mass spectrometry. An agent administration component can be provided to administer an exogenous agent to the tissue. A sampling unit can also be provided to acquire a sample from the... University Health Network

J-aggregate forming nanoparticle

There is provided herein a nanovesicle having a bilayer comprising a saturated first phospholipid and no more than about 15 molar % of a second phospholipid covalently conjugated to a J-aggregate forming dye.... University Health Network

Pyrazolopyrimidine compounds

The present teachings provide a compound represented by the following structural formula: (Formula (I)); or a pharmaceutically acceptable salt thereof. Also described are pharmaceutical compositions and methods of use thereof.... University Health Network

Urinary biomarkers for sle and lupus nephritis

A SLE and/or lupus nephritis (LN) biomarker panel comprising a solid support and two or more biomarker detection agents, each biomarker detection agent specific for a corresponding target biomarker selected from a group of target biomarkers listed herein is provided; as well as methods for measuring biomarker levels, predicting, prognosing,... University Health Network

Photodynamic compounds and methods for activating them using ionizing radiation and/or other electromagnetic radiation for therapy and/or diagnostics

A method for destroying cells and/or microorganisms in an organism includes the following steps: (a) administering to the organism a composition including a photodynamic compound containing at least one transition metal; and (b) irradiating the photodynamic compound in the organism with electromagnetic radiation, wherein the electromagnetic radiation includes ionizing radiation... University Health Network

Immunotherapy for the treatment of cancer

Methods for the treatment of cancer using double negative (DN) T cells are described. The DNTs may be used for the treatment of chemotherapy-resistant cancers such as recurring or relapsing acute myeloid leukemia (AML). The use of allogenic DNTs, such as those derived from healthy donors, that do not exhibit... University Health Network

Organoids for drug screening and personalized medicine

There is provided herein cell culture mediums for generating organoids, including tumour organoids.... University Health Network

Organotellurium compounds, compositions and methods of use thereof

A compound of formula (I) as described herein and methods and uses thereof as probes in the mass tagging of biosensors or biologically active materials for use in mass cytometry analysis of tissue samples such as in the detection, labelling and quantification of oxygen-deprived cells by using, for example, tellurophene-tagged... University Health Network

Multifunctional nanoparticle compositions and uses thereof

Disclosed herein are multifunctional nanoparticle compositions. The compositions can be useful for the treatment of cancer by enhancing the anti-tumor effectiveness of radiation directed to a tissue, cell or a tumor and the methods of use thereof. The multifunctional nanoparticle composition comprises a metal oxide nanoparticle core; a functional coating... University Health Network

Method for t1 mapping with incomplete tissue magnetization recovery

Methods and systems for performing T1 mapping. T1 samples are obtained from an acquisition including one or more inversion groupings. The acquisition may be designed to result in incomplete tissue magnetization recovery between inversion groupings. The acquisition may be designed for the use of non-uniform, non-180° preparatory pulses. The method... University Health Network

Collection and analysis of data for diagnostic purposes

Systems and methods for determining bacterial load in targets and tracking changes in bacterial load of targets over time are disclosed. An autofluorescence detection and collection device includes a light source configured to directly illuminate at least a portion of a target and an area around the target with excitation... University Health Network

Synthesis of chiral 2-(1h-indazol-6-yl)-spiro[cyclopropane-1,3'-indolin]-2'-ones

The present invention is directed to novel synthetic methods for preparing cyclopropyl indolinone compound represented by Structural Formula (A): (A) or its pharmaceutically acceptable salt thereof. Also included are synthetic intermediates described herein.... University Health Network

Pyrazolopyrimidine compounds

The present teachings provide a compound represented by structural formula (I-0), or a pharmaceutically acceptable salt thereof. Also described are pharmaceutical compositions and methods of use thereof.... University Health Network

Method and system for brain activity signal-based treatment and/or control of user devices

A method for characterizing a brain electrical signal comprising forming a temporo-spectral decomposition of the signal to form a plurality of time resolved frequency signal values, associating each instance of the signal value with a predetermined function approximating a neurological signal to form a table of coefficients collectively representative of... University Health Network

Connector apparatus

A locking member for a gate apparatus comprises a body mountable to a gripping array of a support, said body having a mating form mutually engageable with the gripping array, whereby axial motion of said body relative to said gripping array is inhibited. A member extends away from said body,... University Health Network

Il-12 immunotherapy for cancer

Compositions and methods far delivering immune modulatory molecules to result in a therapeutic effect are disclosed. The compositions and methods use stably integrating lentiviral delivery systems. The methods are useful for therapeutically and prophylactically treating cancer such as leukemia.... University Health Network

Angiopoietin-based interventions for treating cerebral malaria

The present invention provides methods for treating, preventing or reducing the severity of cerebral malaria. The methods of the present invention comprise administering to a subject in need thereof a therapeutically effective amount of a pharmaceutical composition comprising a modified angiopoietin molecule such as AngF1-Fc-F1.... University Health Network

Peptide containing porphyrin lipid nanovesicles

There is provided herein a nanovesicle comprising a monolayer of phospholipid, porphyrin-phospholipid conjugate and a peptide encapsulating a hydrophobic core, wherein the peptide comprises an amino acid sequence capable of forming at least one amphipathic α-helix; the porphyrin-phospholipid conjugate comprises one porphyrin, porphyrin derivative or porphyrin analog covalently attached to... University Health Network

Acoustic upper airway assessment system and method, and sleep apnea assessment system and method relying thereon

Described are various embodiments of an acoustic upper airway assessment system and method, and sleep apnea assessment system and method relying thereon. In one embodiment, a non-invasive method is described for assessing upper airway anatomy in a subject while breathing. This method comprises receiving as input at a hardware processor... University Health Network

Anti-transthyretin antibodies

The invention provides antibodies that specifically bind to transthyretin (TTR). The antibodies can be used for treating or effecting prophylaxis of diseases or disorders associated with TTR accumulation or accumulation of TTR deposits (e.g., TTR amyloidosis). The antibodies can also be used for diagnosing TTR amyloidosis and inhibiting or reducing... University Health Network

Fiber optic light delivery, monitoring and apparatus therefore

Apparatus for illuminating comprises one or more fibers, the one or more fibers including fiber portions meeting at an apex and a bottom location to form a three dimensional cage; a detector attached to each of the fiber portions for receiving light and transmitting light along each of the fiber... University Health Network

Antibodies to ttr and methods of use

The disclosure pertains to antibodies and binding fragments thereof that specifically binds all or part of EHAEVVFTA. Also provided are isolated peptides, isolated nucleic acids, immunogens, compositions, immunoassays and kits and method of using said reagents to detect misfolded TTR.... University Health Network

System and focal source identification

Various embodiments are described herein for a system, method, and device for identifying focal source locations of electrophysiological activity in an organ. The system, method and device may also be used to guide catheter ablation of the organ. An electro-gram signal can be obtained from a location in the organ,... University Health Network

Combination therapy with double negative t-cells

There is provided herein methods of treating leukemia or lymphoma in a subject in need thereof, with double negative T cells (DNTs) in combination with Interferon-γ.... University Health Network

Thymidylate kinase fusions and uses thereof

The application also relates to use of these compositions in methods of treatment of diseases such as graft versus host disease and cancer.... University Health Network

Anti-transthyretin antibodies

The invention provides antibodies that specifically bind transthyretin (TTR). The antibodies can be used for treating or effecting prophylaxis of diseases or disorders associated with TTR accumulation or accumulation of TTR deposits (e.g., TTR amyloidosis). The antibodies can also be used for diagnosing TTR amyloidosis and inhibiting or reducing aggregation... University Health Network

Cannula for connecting medical devices to biological systems

A cannula for connecting a medical device to a biological system is taught. The cannula includes a tissue engagement portion, preferably in the form of an annulus, to which a vacuum is applied through the cannula to attract and hold tissue of the biological system in an initial connection while... University Health Network

Method of inhibition of leukemic stem cells

A method for inhibition of leukemic stem cells expressing IL-3Rα (CD123), comprises contacting the cells with an antigen binding molecule comprising a Fc region or a modified Fc region having enhanced Fc effector function, wherein the antigen binding molecule binds selectively to IL-3Rα (CD123). The invention includes the treatment of... University Health Network

Anti-transthyretin antibodies

The invention provides antibodies that specifically bind to transthyretin (TTR). The antibodies can be used for treating or effecting prophylaxis of diseases or disorders associated with TTR accumulation or accumulation of TTR deposits (e.g., TTR amyloidosis). The antibodies can also be used for diagnosing TTR amyloidosis and inhibiting or reducing... University Health Network








ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009



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