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University Of Dundee patents


Recent patent applications related to University Of Dundee. University Of Dundee is listed as an Agent/Assignee. Note: University Of Dundee may have other listings under different names/spellings. We're not affiliated with University Of Dundee, we're just tracking patents.

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The University Of Dundee

. . ... University Of Dundee

University Of Dundee

. . ... University Of Dundee

Derivatives of 1-[(cyclopentyl or 2-pyrrolidinyl)carbonylaminomethyl]-4-(1,3-thiazol-5-yl) benzene which are useful for the treatment of proliferative, autoimmune or inflammatory diseases

There is provided novel small molecule e3 ubiquitin ligase protein binding ligand compounds, having utility in proteolysis targeted chimeras (protacs), as well as processes for the preparation thereof, and use in medicine. There is particularly provided protacs which bind to a protein within the bromo- and extra-terminal (bet) family of proteins, and especially to protacs including novel small molecule e3 ubiquitin ligase protein binding ligand compounds which selectively induce degradation of the brd4 protein within the bromodomain of the bet family of proteins.. ... University Of Dundee

Pyrazolo[3,4-d]pyrimidin derivative and its use for the treatment of leishmaniasis

The compound 3,3,3-trifluoro-n-((1,4-trans)-4-((3-((s)-2-methylmorpholino)-ih-pyrazolo[3,4-d]pyrimidin-6-yl)amino)cyclohexyl)propane-1-sulfonamide having the formula (i) or a salt thereof, its opposite enantiomer, compositions comprising the compound and its use in the treatment or prevention of leishmaniasis, particularly visceral leishmaniasis.. . ... University Of Dundee

Treatment or prophylaxis of proliferative conditions

The invention relates to novel compounds for use in the treatment or prophylaxis of cancers and other proliferative conditions that are for example characterized by cells that express cytochromne p450 1b1 (cyp1b1) and allelic variants thereof. The invention also provides pharmaceutical compositions comprising one or more such compounds for use in medical therapy, for example in the treatment of prophylaxis of cancers or other proliferative conditions, as well as methods for treating cancers or other conditions in human or non-human animal patients. ... University Of Dundee

Sik inhibitor for use in a method of treating an inflammatory and/or immune disorder

The present invention relates to the discovery that salt inducible kinases (siks) suppress the formation of anti-inflammatory molecules such as il-10, which are important for the resolution of inflammation and identifies sik inhibitors that may be used to treat disorders associated with undesirable inflammation, such as inflammatory bowel disease and/or autoimmune disorders.. . ... University Of Dundee

Cysteine labelling

The present invention relates to the production of activated biological molecules for use in profiling biological molecule interactions. The activated biological molecule may be a ubiquitin (ub) and ubiquitin-like conjugation enzyme as well as other proteins with internal reactive cysteine residues.. ... University Of Dundee

Predicting rapid decline in renal function in diabetes

Methods of predicting rapid decline in renal function in diabetes employing panels of biomarkers. The methods are useful for predicting risk of decline of renal function in individual subject and also for selecting subjects for clinical trials.. ... University Of Dundee

Complaint actuator

An actuator (12) includes a moving member (18) pivotally connected to a base unit (14) for rotation about an axis. The driving force for rotation of the moving member (18) relative to the base unit (14) is provided by a pair of antagonistically operating shape memory alloy (sma) wires (48, 50) and transmitted via a torsional spring (56). ... University Of Dundee

Welded glass product and method of fabrication

A method for welding together glass workpieces where one of the workpieces has metal nanoparticles positioned at or near the surface to be welded. The method comprises positioning the workpieces in operative contact at an interface where a weld is to be formed, applying a laser beam to be incident upon the interface wherein energy from the laser beam is absorbed by the nanoparticle bearing workpiece and the energy from the laser beam is transferred to the glass surrounding the metal nanoparticles to heat the glass and to weld the workpieces together.. ... University Of Dundee








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