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University Of Iowa Research Foundation patents


Recent patent applications related to University Of Iowa Research Foundation. University Of Iowa Research Foundation is listed as an Agent/Assignee. Note: University Of Iowa Research Foundation may have other listings under different names/spellings. We're not affiliated with University Of Iowa Research Foundation, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "U" | University Of Iowa Research Foundation-related inventors


Use of anti-cgrp antibodies and antibody fragments to treat diarrhea in subjects with diseases or treatments that result in elevated cgrp levels

The present invention is directed to methods for treating diarrhea, both chronic or acute forms, by the administration of a therapeutically or prophylactically effective amount of antibodies and fragments thereof having binding specificity for cgrp. In particular the methods prevent or reduce diarrhea in conditions or treatments resulting in elevated cgrp levels, e.g., in the gi tract (colon) that are associated with diarrhea and/or improper electrolyte and fluid excretion from the bowel or urinary system. ... University Of Iowa Research Foundation

Use of nad precursors for breast enhancement

Certain embodiments of the invention provide a method for breast enhancement in a female mammal (e.g., a human) in need thereof, comprising administering an effective amount of a nicotinamide adenine dinucleotide (nad) precursor to the mammal.. . ... University Of Iowa Research Foundation

Methods for treating tumors in situ including intratumor injection of cytotoxic particles and immune checkpoint blockade therapy

Disclosed are compositions, kits, and methods for treating cancer in a subject in need thereof. The compositions, kits, and methods may be used to treat a tumor in a subject in situ. ... University Of Iowa Research Foundation

Nucleic acid aptamers to treat histone-induced disease states

The present invention relates to optimized aptamers and methods of using these aptamers.. . ... University Of Iowa Research Foundation

Catheters, catheter systems, and methods for puncturing through a tissue structure and ablating a tissue region

A percutaneous catheter system for use within the human body and an ablation catheter for ablating a selected tissue region within the body of a subject. The percutaneous catheter system can include two catheters that are operatively coupled to one another by magnetic coupling through a tissue structure. ... University Of Iowa Research Foundation

University Of Iowa Research Foundation

. . ... University Of Iowa Research Foundation

Vaccine, therapeutic composition and methods for treating or inhibiting cancer

The present invention provides a method of preparing an anti-cancer composition comprising activated immune cells and a pharmaceutically acceptable excipient. The present invention further provides a method of contacting immune cells obtained from an animal with an optimal combination of activating agents and with an immunogenic material to form the activated immune cells.. ... University Of Iowa Research Foundation

Compositions and methods for treating anxiety and compulsive behavior

Provided herein is compositions and methods for treating anxiety, obsession and/or pathologically compulsive behavior associated with various neuropsychiatric diseases.. . ... University Of Iowa Research Foundation

Viral rna segments as immunomodulatory agents and vaccine components

The disclosure provides compositions and methods involving viral rna segments for use in modulating immune responses, including inhibition inflammation related to pathogenic t-cell activation. In addition, modification of the viral sequences responsible for modulating immune response provides for improved vaccine formulations.. ... University Of Iowa Research Foundation

Methods and compositions for treating brain diseases

The present disclosure provides methods for treating or preventing huntington's disease (hd) in a subject in need thereof, comprising administering a therapeutic agent that activates mtorc 1 function and/or increases ras homolog enriched in striatum (rhes) level in the subject's brain as compared to the function or level in the subject prior to treatment, and methods for modulating mhtt-associated metabolic phenotypes and/or reversal of striatal atrophy by administering a therapeutic agent that activates mtorc1 function and/or increases ras homolog enriched in striatum (rhes) level in the subject's brain as compared to the function or level in the subject prior to treatment.. . ... University Of Iowa Research Foundation

Methods for the regeneration of articular cartilage in vivo

A pharmaceutical composition is provided that is useful to enhance the repair of articular cartilage, to treat a joint injury or to prevent, inhibit or treat osteoarthritis in a mammal. The composition may include an effective amount of an isolated protein that is a chemoattractant for chondrogenic progenitor cells and/or an effective amount of an isolated protein that is a chondro genic factor or a nucleic acid sequence that encodes a chondrogenic factor.. ... University Of Iowa Research Foundation

Reduction of off-target rna interference toxicity

The present invention is directed to rna interference (rnai) molecules targeted against a nucleic acid sequence, and methods of using these rnai molecules to reduce off-target toxicity.. . ... University Of Iowa Research Foundation

Methods and reagents for treatment of age-related macular degeneration

The invention relates to factor h gene polymorphisms and haplotypes associated with an elevated or a reduced risk of amd. The invention provides methods and reagents for diagnosis and treatment of amd.. ... University Of Iowa Research Foundation

Miniature grism system for astronomical spectroscopy

The invention is directed at a miniature grism system. The miniature grism system is a single compact device that comprises a grism with collimating and focusing optics. ... University Of Iowa Research Foundation

12/14/17 / #20170356045

Genes and polymorphisms associated with amd

There is provided a method of screening for susceptibility to complement dysregulation in an individual, the method including screening for the presence or absence of a genetic profile characterized by polymorphisms in the genome of the individual associated with complement dysregulation. The presence of a genetic profile is indicative of the individual's risk of complement dysregulation.. ... University Of Iowa Research Foundation

12/07/17 / #20170348386

Methods and compositions for treating brain diseases

The present disclosure provides targeting peptides and vectors containing a sequence that encodes targeting peptides that deliver agents to the brain.. . ... University Of Iowa Research Foundation

11/30/17 / #the present invention is directed to methods of inhibiting or preventing photophobia in subjects in need thereof using anti-cgrp antibodies or antibody fragments that inhibit photophobia, especially cgrp-associated photophobia. these antibodies and fragments are useful in treating different disorders associated with photophobia such as migraine, cluster headaches and the like.

The University Of Iowa Research Foundation

. . ... University Of Iowa Research Foundation

11/23/17 / #20170335318

Rna interference suppression of neurodegenerative diseases and methods of use thereof

The present invention is directed to small interfering rna molecules (sirna) targeted against nucleic acid sequence that encodes huntingtin or ataxin-1, and methods of using these sirna molecules.. . ... University Of Iowa Research Foundation

11/23/17 / #20170333896

Fluid handling systems for application of fluid shear stress to a fluid sample

A fluid handling system for applying a plurality of pulses of fluid shear stress to a fluid sample may comprise a first sample chamber; a second sample chamber; a plurality of conduits mounted between and in fluid communication with the first sample chamber and the second sample chamber; and a force delivery system mounted to the first sample chamber and configured to apply a force sufficient to push the fluid sample from the first sample chamber through each of the conduits at a substantially constant flow rate to the second sample chamber. The plurality of conduits may be arranged in series and separated by additional sample chambers or arranged such that the conduits are substantially parallel to one another. ... University Of Iowa Research Foundation

11/16/17 / #20170326075

Thymol and carvacol for use in medicine

The invention provides therapeutic methods comprising the administration of thymol or carvacrol, or a pharmaceutically acceptable salt or prodrug thereof. The methods are useful for modulating muscle atrophy, performance, recovery, generation, or maintenance in animals.. ... University Of Iowa Research Foundation

11/09/17 / #20170321190

Methods to generate epithelial cells

The invention provides in certain embodiments, a method of generating a re-programmed differentiated epithelial cell comprising (a) contacting a non-stem somatic cell obtained from a subject with an effective amount of a de-differentiation agent to form a de-differentiated cell, and (b) transfecting the de-differentiated cell with an expression cassette comprising a promoter operably linked to a nucleic acid encoding a conversion agent to form a re-programmed differentiated cell. The invention also provides in certain embodiments, a method of generating a re-programmed differentiated epithelial cell comprising (a) contacting a non-stem somatic cell obtained from a subject with an effective amount of a de-differentiation agent to form a de-differentiated cell, and (b) contacting the de-differentiated cell with a conversion agent to form a re-programmed differentiated cell. ... University Of Iowa Research Foundation

10/26/17 / #the invention provides a compound of formula i:

University Of Iowa Research Foundation

. . ... University Of Iowa Research Foundation

10/26/17 / #20170307592

Neuroprotective chemicals and methods for identifying and using same

Provided herein are methods for identifying a compound having cell-protective (e.g., neuroprotective) activity. Compounds identified therefrom are also provided. ... University Of Iowa Research Foundation

10/26/17 / #20170306355

Modified adeno-associated virus vector compositions

An adeno-associated virus filler component comprising a nucleic acid of between 3300 and 4200 nucleotides in length is disclosed.. . ... University Of Iowa Research Foundation

10/26/17 / #20170306326

Microrna inhibitor system and methods of use thereof

The present invention relates to plasmid-based mir inhibitory systems (pmis), mir inhibitors and methods of use of these systems and inhibitors.. . ... University Of Iowa Research Foundation

10/12/17 / #20170290929

Grp78 targeted conjugates

Accordingly, certain embodiments of the invention provide a conjugate of formula (i): p-(x-d)n, wherein p is a peptide that binds to a glucose regulated protein 78 (grp78); x is a direct bond or a linking group; d is a detectable agent; and n is 1 to 4. Certain embodiments of the invention provide a pharmaceutical composition comprising a conjugate of formula (i) and a pharmaceutically acceptable excipient. ... University Of Iowa Research Foundation

10/05/17 / #20170288666

Voltage-controlled magnetic-based devices having topological insulator/magnetic insulator heterostructure

A voltage-controlled magnetic based device is described that includes a magnetic insulator; a topological insulator adjacent the magnetic insulator; and magnetic dopants within the topological insulator. The magnetic dopants are located within an edge region of the topological insulator to inhibit charge current flow in the topological insulator during a switching operation using an applied electric field generating by applying a switching voltage across two electrodes at opposite sides of the topological insulator. ... University Of Iowa Research Foundation

09/28/17 / #20170273794

Cranioplasty plate

A cranial plate is provided for use after a craniectomy. The plate is mounted to the skull and protects the brain exposed in the skull opening. ... University Of Iowa Research Foundation

09/14/17 / #20170260285

Methods for treating cancer

The present invention relates to pharmaceutical compositions and methods of treating cancer in a subject, the method comprising administering to the subject a combination therapy comprising administering (1) at least one anti-cancer therapy, and (2) a pharmaceutical composition comprising a pharmaceutically acceptable carrier and an amount of an il-1α inhibitor, wherein the combination therapy is effective to reduce at least one symptom of the cancer in the subject.. . ... University Of Iowa Research Foundation

09/14/17 / #20170258058

Transgenic pig models of cystic fibrosis

This invention relates to transgenic pig models of cystic fibrosis, cells that can be used to make such animals, and methods of making and using these pigs and cells.. . ... University Of Iowa Research Foundation

08/24/17 / #20170240966

Predicting amd with snps within or near c2, factor b, plekha1, htra1, prelp, or loc387715

The invention relates to gene polymorphisms and genetic profiles associated with an elevated or a reduced risk of a complement cascade dysregulation disease such as amd. The invention provides methods and reagents for determination of risk, diagnosis and treatment of such diseases. ... University Of Iowa Research Foundation

08/24/17 / #20170240864

Methods to generate pancreatic beta cells from skin cells

In certain embodiments, the present invention provides methods to prepare insulin secreting cells from a skin sample from a mammal.. . ... University Of Iowa Research Foundation

08/24/17 / #20170239491

Real-time application position monitoring system

A real-time applicator position monitoring system (raps) measures brachytherapy applicator displacement in real-time by computing the relative displacement between two infrared reflective targets, one attached to the applicator and the other to the patient's skin. In an aspect, raps can be used with any brachytherapy application. ... University Of Iowa Research Foundation

08/17/17 / #20170236282

Automated assessment of glaucoma loss from optical coherence tomography

Systems and methods for assessing glaucoma loss using optical coherence topography. One method according to an aspect comprises receiving optical coherence image data and assessing functional glaucoma damage from retinal optical coherence image data. ... University Of Iowa Research Foundation

08/10/17 / #20170226512

Nucleic acid aptamers

The present invention relates to optimized aptamers and methods of using these aptamers.. . ... University Of Iowa Research Foundation

08/10/17 / #20170225967

Use of magnetic mesoporous silica nanoparticles for removing uranium from media

The present invention is directed to a method of removing uranium from a uranium containing aqueous medium. The method comprises a step of contacting the medium with magnetic mesoporous silica nanoparticles. ... University Of Iowa Research Foundation

07/13/17 / #20170200399

Precise, low-cost orthopaedic surgical simulator

An orthopaedic surgical simulator includes a bone (a simulated bone or cadaver bone). The simulator further includes a base, wherein the bone is operatively connected to the base, an optical system mounted proximate the base, wherein the optical system comprises at least one camera and provides a first view and a second view of an incision area associated with the bone. ... University Of Iowa Research Foundation

06/22/17 / #20170173363

Close-proximity range shifting device for proton radiosurgery

A range shifting device configured to be placed close to a portion of a body of a patient during radiation beam treatment. The radiation beam treatment can include stereotactic radiosurgery (srs). ... University Of Iowa Research Foundation

06/22/17 / #20170172991

Image guided therapy for cancer

The invention provides a method to treat cancer in an animal comprising administering a tetra-arylethylene cation to the animal.. . ... University Of Iowa Research Foundation

06/15/17 / #20170166924

Methods for producing and using in vivo pseudotyped retroviruses

The present invention provides novel pseudotyped retroviral vectors that can transduce human and other cells. Vectors are provided that are packaged efficiently in packaging cells and cell lines to generate high titer recombinant virus stocks expressing novel envelope glycoproteins. ... University Of Iowa Research Foundation

06/15/17 / #20170165500

Advanced rotating-shield brachytherapy and planning of the same

Systems and methods for rotating shield brachytherapy. In an aspect, some of the systems and methods can be used to facilitate shield selection for use in rotating shield brachytherapy. ... University Of Iowa Research Foundation

06/01/17 / #20170151029

Catheters, catheter systems, and methods for puncturing through a tissue structure and ablating a tissue region

A percutaneous catheter system for use within the human body and an ablation catheter for ablating a selected tissue region within the body of a subject. The percutaneous catheter system can include two catheters that are operatively coupled to one another by magnetic coupling through a tissue structure. ... University Of Iowa Research Foundation

05/11/17 / #20170132382

Method for determining programmatically expected disease recurrence likelihood

The disclosure is directed a computer implemented method for determining the likelihood of recurrence of a disease.. . ... University Of Iowa Research Foundation

04/20/17 / #compounds of formula i:

University Of Iowa Research Foundation

. . ... University Of Iowa Research Foundation

04/13/17 / #20170100370

Compositions and methods for cancer therapy

The invention provides compositions and methods to treat a hyperproliferative disorder with ascorbate or a pharmaceutically acceptable salt thereof, at least one chelating agent that enhances ascorbate redox cycling (edta) to form h2o2, and one or more anti-cancer therapies.. . ... University Of Iowa Research Foundation

04/06/17 / #20170098311

Graph search using non-euclidean deformed graph

Disclosed are methods and systems for analyzing data. An example method can comprise receiving volume data representative of an object. ... University Of Iowa Research Foundation

03/23/17 / #20170082717

Apparatus and methods for dynamical tracking of mechanical activity wthin cell populations

Apparatus and methods for dynamical tracking of movement of cells and cell groups within cell populations using magnetic resonance imaging are provided.. . ... University Of Iowa Research Foundation

03/09/17 / #20170065577

Therapeutic compositions and methods

Therapeutic methods and compositions for treating fibrosis (e.g. Scarring) are provided, as well as compositions comprising blebbistatin or a salt thereof and plga and nanoparticles comprising blebbistatin or a salt thereof and plga.. ... University Of Iowa Research Foundation

02/02/17 / #20170031386

Multi-screen display system, devices and methods

The disclosed apparatus, systems and methods relate to a collapsible, freestanding display unit. The display unit can be a collapsible and transportable stack system, which may include a base unit. ... University Of Iowa Research Foundation

02/02/17 / #20170030897

Neuroprotective chemicals and methods for identifying and using same

Provided herein are methods for identifying a compound having cell-protective (e.g., neuroprotective) activity. Compounds identified therefrom are also provided. ... University Of Iowa Research Foundation

02/02/17 / #20170028201

Method for causing stochastic polarization in the spinal cord to inhibit transmission of synchronous action potentials

This invention provides a new technology for management of back pain by stimulating the spinal cord in a manner that renders it refractory to transmission of deleterious or undesirable sensory input. The electrical stimulus comprises high frequency pulses in a regular or complex pattern or that are stochastically produced under microprocessor control. ... University Of Iowa Research Foundation








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