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University Of Maryland Baltimore
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University Of Maryland Baltimore patents


Recent patent applications related to University Of Maryland Baltimore. University Of Maryland Baltimore is listed as an Agent/Assignee. Note: University Of Maryland Baltimore may have other listings under different names/spellings. We're not affiliated with University Of Maryland Baltimore, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "U" | University Of Maryland Baltimore-related inventors


Compositions and methods for producing bacterial conjugate vaccines

Longer chain antigenic O-polysaccharide chains for use as a hapten in conjugate vaccines can be produced in a controlled manner using recombinant Gram-negative bacteria that overexpress native or heterologous genes of the wzz family, for example wzzB. Bacteria expressing a chosen wzz gene have modified O-polysaccharide chain lengths, allowing the... University Of Maryland Baltimore

Runx2 transcription factor inhibitors and uses thereof

Substituents R1 and R2 independently are H, Cl, F, Br, CH3, CF3, SH, —N(C1-3alkyl)2, —NHC(O)C1-3alkyl, or —NHC(O)C5-7cycloalkyl, substituent R3 is H or C1-3 alkyl and R4 is a bridged cycloalkene such as a bridged cyclohexene or a bridge-substituted cyclohexene. The compounds are therapeutics to treat a cancer, such as breast... University Of Maryland Baltimore

Inhibitors of the notch transcriptional activation complex and methods for use of the same

Disclosed herein are inhibitors of the Notch transcriptional activation complex, and methods for their use in treating or preventing diseases, such as cancer. The inhibitors described herein can include compounds of Formula (I) and pharmaceutically acceptable salts thereof: Formula (I), wherein the substituents are as described.... University Of Maryland Baltimore

Coaptation ultrasound devices and methods of use

Disclosed is a system and method for the placement of elongate medical members within a patient's body using coaptive ultrasound that combines magnetic guidance with ultrasound visualization of the medical member in the patient's body. A coaptive ultrasound probe adaptor magnetically attracts an elongate medical member within the patient with... University Of Maryland Baltimore

Biomarkers for diagnosis and prognosis of lung cancer

Provided herein are methods for non-invasively diagnosing and/or prognosing a lung cancer and for determining the efficacy of a therapeutic treatment regimen for the lung cancer. Expression levels of at least two small non-coding RNAs, for example, microRNAs and small nucleolar RNAs, are measured and used to calculate an area... University Of Maryland Baltimore

Universal antibody-mediated biosensor

A universal antibody-mediated biosensor is provided that comprise a biosensor cell line stably expressing a novel chimeric fusion protein that can be used to detect target agents in a sample. The fusion protein has an extracellular antibody-binding domain that binds antibodies without regard to their binding specificity and a signaling... University Of Maryland Baltimore

Biomarker kit for metastatic breast cancer prognosis and uses thereof

Provided herein are kits for detecting and quantifying the level of a metastatic cancer biomarker(s) in a patient. The kits may contain a detection and quantifying means, such as, biomarker specific antibodies. Also provided are methods for determining a prognosis, a stratification and/or monitoring of a metastatic cancer in a... University Of Maryland Baltimore

Inhibitors of ncca-atp channels for therapy

Methods and compositions are provided that are utilized for treatment and/or prevention of intraventricular hemorrhage or progressive hemorrhagic necrosis (PHN), particularly following spinal cord injury. In particular, the methods and compositions are inhibitors of a particular NCCa-ATP channel and include, for example, inhibitors of SUR1 and/or inhibitors of TRPM4. Kits... University Of Maryland Baltimore

Muc1 decoy peptides for treatment and prevention of bacterial infections

Pseudomonas aeruginosa flagellin protein recruits the mammalian host sialidase enzyme neuraminidase-1 (NEU1) to remove sialic acid residues from the extracellular domain of the mammalian cell-surface protein MUC1 (MUC1-ED), thereby exposing a cryptic binding site on the MUC1-ED protein backbone for flagellin binding. NEU1-driven MUC1-ED desialylation rapidly increases P. aeruginosa adhesion... University Of Maryland Baltimore

Self-sealing cannula

The present invention discloses a self-sealing cannula and methods of its use. The self-sealing cannula can be minimally invasively placed into the heart for drawing and/or returning blood with a self-sealing function at the interface of the blood access site. The disclosed cannula can be implemented as a single lumen... University Of Maryland Baltimore

Treatment of cancer and inhibition of metastasis using hemoglobin beta subunit

The beta 2 subunit of mouse hemoglobin (HBB2) has been identified as soluble factor from mouse lungs that exhibits cytostatic/cytotoxic activity against neuroblastoma lung micrometastases. The beta subunit of human hemoglobin (HBB) has been found to have similar activity. Methods of using these proteins and fragments thereof in the treatment... University Of Maryland Baltimore

Methods for treating neural cell swelling

A composition comprising a novel Ca2+-activated, [ATP]i-sensitive nonspecific cation (NCCa-ATP) channel is described. The channel is found in mammalian neural cells and exhibits a different sensitivity to block by various adenine nucleotides, and is activated by submicromolar [Ca]i. The NCCa-ATP channel is activated under conditions of ATP depletion, which causes... University Of Maryland Baltimore

Targeting ncca-atp channel for organ protection following ischemic episode

The present invention concerns protection of an organ or tissue outside of the central nervous system following an ischemic episode. In particular aspects, the invention concerns organ preservation for transplantation, angina pectoris, kidney reperfusion injury, and so forth. In specific embodiments, the organ is subjected to an inhibitor of an... University Of Maryland Baltimore

Histatin-5 based synthetic peptides and uses thereof

Provided herein are synthetic peptides or synthetic fragments thereof based on a Histatin-5 peptide, for example with a sequence DSHAKRHHGYKRKFHEKHHSHRGY (SEQ ID NO: 1). The synthetic peptides or synthetic fragments have at least one substituted amino acid that is arginine and/or leucine to increase resistance to proteolytic degradation by a... University Of Maryland Baltimore

Stable immunogen based on inner domain of hiv-1 gp120 for inducing immunity against hiv

Stable immunogens comprising portions of the inner domain (ID) of the Human Immunodeficiency Virus (HIV-1) gp120 protein are provided. These ID immunogens selectively present the gp120 C1/C2 region in its CD4-bound state within a minimal structure. These ID immunogens can be used to vaccinate subjects against infection with HIV, the... University Of Maryland Baltimore

Multi-functional fluid flow device

The present invention relates to a fluid flow device. The device includes an elongate body having a proximal end, a distal end, and a length therebetween, at least one source fluid inflow port, at least one waste fluid outflow port, at least one well inlet port positioned at the distal... University Of Maryland Baltimore

Central pressurized cadaver model

Provided are methods for creating a pressurized cadaver model used for surgical procedure training. In the method the internal jugular veins, common carotid arteries, brachial arteries, superficial femoral arteries and femoral veins thereof of a cadaver are exposed. One internal jugular vein is ligated and a drainage tube is disposed... University Of Maryland Baltimore

Nonsteroidal and steroidal compounds with potent androgen receptor down-regulation and anti prostate cancer activity

Nonsteroid and steroid compounds that cause down-regulation of the androgen receptor (AR), both full length and splice variant, induce apoptosis and inhibit proliferation of inhibiting proliferation and migration of androgen sensitive cancer cells. The steroid compounds and nonsteroid compounds may be agents for the prevention and/or treatment of cancer, including... University Of Maryland Baltimore

Biomarkers predictive of lupus progression and uses thereof

Methods, systems and kits to detect and/or quantify lupus and disease progression in a subject having, or at risk of having, lupus are disclosed.... University Of Maryland Baltimore

Method and transapical procedures on a mitral valve

Apparatus and methods for performing a non-invasive procedure to repair a cardiac valve are described herein. In some embodiments, apparatus and methods are described herein for repairing a mitral valve using an edge-to-edge repair to secure the mitral valve leaflets. Implant securing devices are also described that can be used... University Of Maryland Baltimore

Artificial lung system and its methods of use

An oxygen supply unit for use with a blood oxygenator comprises an oxygen concentrator and a carbon dioxide scrubber. In an on-line operational mode, oxygen-rich gas from the oxygen concentrator is predominantly supplied to the blood oxygenator with a reduced flow of recycled gas from the concentrator. In an off-line... University Of Maryland Baltimore

System and optimizing a treatment plan for irradiation therapy using multi-criteria optimization (mco)

A method and apparatus is presented for optimizing a treatment plan for irradiation therapy. The method includes defining a single objective function based on a plurality of objective functions that are each associated with a plurality of tissue types within a subject, upper and lower bounds for each objective function... University Of Maryland Baltimore

Methods and devices for multi-step cell purification and concentration

Described herein are microfluidic devices and methods that can separate and concentrate particles in a sample.... University Of Maryland Baltimore

Methods for treating cardiovascular dysfunction and improving fluid homeostasis with a peptide hormone

The present invention generally to methods of treating subjects suffering from a cardiac condition or having a risk factor for developing a cardiac condition by administering an ELA peptide or fusion protein to a subject in need. The invention relates to fusion proteins of Fc-ELA-32 and Fc-ELA-21 that exhibit improved... University Of Maryland Baltimore

Immunoglobulin constant region fc receptor binding agents

IVIG replacement compounds are derived from recombinant and/or biochemical creation of immunologically active biomimetic(s). These replacement compounds are then screened in vitro to assess each replacement compound's efficiency at modulating immune function. Particular replacement compounds are selected for further in vivo validation and dosage/administration optimization. Finally, the replacement compounds are... University Of Maryland Baltimore

Methods and systems for processing particles

Described herein are improved microfluidic devices and methods for processing cells that can improve cell quality, streamline workflows, and lower costs. Applications include research and clinical diagnostics in cancer, infectious disease, and inflammatory disease, among other disease areas.... University Of Maryland Baltimore

Method of extracting lipids from microbes

Improved methods for extracting lipid-containing molecules from microbes are disclosed. The methods utilize selected surfactants for extraction of lipids and lipopolysaccharides from microbes, such as bacteria and fungi. The extracted lipids and lipopolysaccharides may be used, for example, to identify the source microbe via mass spectroscopy.... University Of Maryland Baltimore

Pathogen identification in complex biological fluids

Provided herein are methods for rapidly identifying a microbe, such as a pathogen, from a biological sample including, blood, urine, wound effluent, stool, serum, and bronchoalveolar lavage fluid. The method comprises obtaining the sample from the subject and performing a spectrometric analysis of the lipids in the microbe to obtain... University Of Maryland Baltimore

System and assessment of cardiac stroke volume and volume responsiveness

Disclosed are systems and methods using ultrasound to predict if a patient's cardiac stroke volume will increase with a fluid bolus. Ultrasound measures are taken before administering a fluid bolus, including measurement of the left ventricular outflow tract velocity time integral (LVOT VTI), and venous measurements of the internal jugular... University Of Maryland Baltimore

Protein-repellent dental materials and use thereof in dental applications

The present invention provides protein-repellent dental materials that can be widely applied in a variety of dental applications. The protein-repellent dental materials of the invention include dental primers, dental adhesives, dental resins, dental composites, dental bonding systems and the like, as well as dental cements, dental sealants, dental bases and... University Of Maryland Baltimore

Recombinant t cell receptor ligand compositions and methods for treatment of prostate cancer

Disclosed herein are compositions and methods for treating or inhibiting prostate cancer. The compositions include a MHC molecule including covalently linked first and second domains, wherein the first domain is an MHC class II β1 domain and the second domain is an MHC class II α1 domain, wherein the amino... University Of Maryland Baltimore

System, transient electric field detection and display

Disclosed are systems, devices and methods for detecting and measuring TMS-induced electrical fields. In accordance with certain aspects of an embodiment of the invention, a TMS sensor probe is provided having a field detector, a first electrical connection connecting the field detector to either a power source or a processor,... University Of Maryland Baltimore

Microtentacle imaging in patient tumor samples

The present invention provides a method for imaging microtentacles on isolated, living, non-adherent primary tumor cells from a cancer subject comprising: i) obtaining one or more living, non-adherent primary tumor cells that has been isolated from a solid tumor from the subject; and ii) imaging the one or more living,... University Of Maryland Baltimore

Methylated peptides derived from tau protein and their antibodies for diagnosis and therapy of alzheimer's disease

In sporadic Alzheimer's disease, neurofibrillary lesion formation is preceded by extensive post-translational modification of the microtubule associated protein tau. Immunoassays have been developed recently that detect tau in biological specimens, thus providing a means for pre-mortem diagnosis of Alzheimer's disease, which has remained elusive. These assays have been improved by... University Of Maryland Baltimore

Surgical drain sutured-in-place prevention device

The present invention discloses systems and methods to alert a medical operator that a surgical drain has been sutured in place within a patient's body. A readily removable sheath is provided at a distal end of a surgical drain. The sheath is configured to be placed within a surgical wound... University Of Maryland Baltimore

06/22/17 / #20170174620

Linked diaryl compounds with anticancer properties and methods of using the same

Provided are compositions comprising linked diaryl compounds that possess anticancer properties. Methods of use are also disclosed herein. The method comprises administering an effective amount of a compound described herein to an individual in need thereof.... University Of Maryland Baltimore

06/08/17 / #20170156690

Techniques for suppression of motion artifacts in medical imaging

Techniques for suppression of motion artifacts in medical imaging include obtaining projections at different times within a time interval from a medical imaging system operating on a subject. A stationary projection is determined for a first subset of the projections in which a signal source and detector array of the... University Of Maryland Baltimore

06/01/17 / #20170152318

Methods and compositions for modulation of blood-neural barrier

Methods and compositions for modulating blood-neural barrier (BNB) for the treatment of CNS conditions such as edema, and for increased drug delivery efficacy across the BNB. The present invention further relates to improved tPA treatment of ischemic cerebrovascular and related diseases in combination with antagonism of the PDGF signaling pathway.... University Of Maryland Baltimore

05/18/17 / #20170135699

Apparatus and placement of device along wall of a body lumen

An apparatus (100) includes: a expandable structure (140) formable into three dimensional shapes including a range of diameters (D) and corresponding lengths (L); a movable component (106) moveable between a range of positions (124, 126) effecting the range of diameters; and a mechanical linkage (110) disposed between the movable component... University Of Maryland Baltimore

04/27/17 / #20170112723

Nanostructured antibacterial and remineralizing dental bonding agents and dental bonding systems

The present invention provides dental bonding agents and dental bonding systems comprising the dental bonding agents. The dental bonding agents of the invention are characterized by having antibacterial properties, and in some aspects of the invention, remineralizing properties.... University Of Maryland Baltimore

04/27/17 / #20170112860

Novel non-selective cation channel in neuronal cells and methods for treating brain swelling

The present invention is directed to therapeutic compounds, treatment methods, and kits affecting the NCCa-ATP channel of neural tissue, including neurons, glia and blood vessels within the nervous system, and methods of using same. The NCCa-ATP channel is newly expressed in neural tissue following injury such as ischemia, and is... University Of Maryland Baltimore

03/23/17 / #20170081390
03/02/17 / #20170058040

Chemoenzymatic glycoengineering of antibodies and fc fragments thereof

The present invention provides for recombinant Endo-S mutants that exhibit reduced hydrolysis activity and increased transglycosylation activity for the synthesis of glycoproteins wherein a desired sialylated oxazoline or synthetic oligosaccharide oxazoline is added to a core fucosylated or nonfucosylated GlcNAc-protein acceptor. Such recombinant Endo-S mutants are useful for efficient glycosylation... University Of Maryland Baltimore

02/02/17 / #20170027975

Methods of treating coronavirus infection

The present invention provides methods for treating a coronavirus infection. For example, treatment may be effected by administering a neurotransmitter inhibitor, a signaling kinase inhibitor, an estrogen receptor inhibitor, a DNA metabolism inhibitor or an anti-parasitic agent. Also provided are methods for treating a coronavirus infection in which an anti-viral... University Of Maryland Baltimore

01/26/17 / #20170020892

Use of negative modulators of gaba receptors containing alpha5 subunits as fast acting antidepressants

Embodiments of the disclosure include methods and compositions related to treatment of one or more medical conditions with one or more negative modulators of GABAA receptors. In specific embodiments, depression and/or suicidability is treated or ameliorated or prevented with one or more negative modulators of GABAA receptors, such as a... University Of Maryland Baltimore

01/26/17 / #20170021187

Methods and systems for controlling magnetic fields and magnetic field induced current

The present invention discloses methods and systems to control magnetic fields and magnetic field induced currents, and more particularly to provide stimulations within a patient's body, such as deep brain stimulation, in a non-invasive manner and with greater focus and control than has been afforded by prior known methods and... University Of Maryland Baltimore

01/05/17 / #20170000931

Para-xylene films and therapeutic uses thereof

The present invention provides single sheet and compound para-xylene films for therapeutic uses. For example, the present invention provides single sheet para-xylene films useful as tissue separators and/or adhesion barriers in a subject, where the top and/or bottom surfaces of such films have a water contact angle between 75 and... University Of Maryland Baltimore

03/29/18 / #20180088008

Actively shaken in-situ passive sampling device

A vibrating platform for the deploying of passive sampling devices in sediments and other media to be sampled. The vibrating platform can greatly enhance the rate of mass transfer of analytes, such as polycyclic aromatic hydrocarbons and polychlorinated biphenyls, into passive sampler material by disrupting the formation of a depletion... University Of Maryland Baltimore

03/29/18 / #20180088114

Ultra-fast pathogen toxin detection assay based on microwave-accelerated metal-enhanced fluorescence

The present invention provides for a system and method to detect low levels of the anthrax protective antigen (PA) exotoxin in biological fluids, wherein the system uses a metal-enhanced fluorescence (MEF)-PA assay in combination with microwave-accelerated PA protein surface absorption. Microwave irradiation rapidly accelerates PA deposition onto the surface adjacent... University Of Maryland Baltimore

01/18/18 / #20180015052

Design, synthesis and methods of use of acyclic flexmier nucleoside analogues having anti-coronavirus activity

The present invention is directed to compounds, methods and compositions for treating or preventing viral infections using nucleosides analogs. Specifically, the present invention provides for the design and synthesis of acyclic fleximer nucleoside analogues having increased flexibility and ability to alter their conformation structures to provide increased antiviral activity potential... University Of Maryland Baltimore

11/30/17 / #20170342458

Biomass containment device

A biomass containment device (BCD) and methods of measuring microbial growth or enzyme activity in the presence of insoluble substrates using the BCD is described. The BCD is compatible with microbial growth and enzyme assays, is sterilizable, is reusable, and the size can be varied to fit any container.... University Of Maryland Baltimore

11/16/17 / #20170327427

Phosphorus extraction and recovery system (pears)

Separation methods and systems for converting high concentrations of animal wastes into nutrients and other useful products such as struvite and potassium struvite. Advantageously, the system and methods do not require the addition of external chemicals other than an acid and a base.... University Of Maryland Baltimore

10/19/17 / #20170299513

Tuning of metal enhanced emissions of long-lived luminescent compounds

The present invention provides for the surface plasmon-enhancement of long lived luminescent compounds, thereby providing for methods and systems having enhanced and controllable rates of the radiative emission of such relaxation of long lived luminescent compounds. The present invention achieves acceleration of the radiative processes by the interaction of the... University Of Maryland Baltimore

08/10/17 / #20170226181

Soluble cd80 as a therapeutic to reverse immune suppression in cancer patients

The present invention provides for a therapeutic cancer treatment using a soluble CD80 fusion protein that binds to PDL1 and inhibits PDL1-PD1 interactions thereby overcoming PDL1-induced immune suppression and restoring T cell activation.... University Of Maryland Baltimore

06/22/17 / #20170174577

Nutrient extraction and recovery device for isolation and separation of target products from animal produced waste streams

The present invention provides for nutrient extraction and recovery devices that use the Donnan Membrane Principle (DMP) to cause spontaneous separation of dissolved ions along electrochemical potential gradients, wherein anions and cations such as H2PO4−, HPO42−, PO43−, Mg2+, Ca2+, NH4+, and K+ are moved from manure containing waste streams through... University Of Maryland Baltimore

06/15/17 / #20170166929

Method of converting marine fish waste to biomethane

Methods employed for the discovery, enrichment, and characterization of a marine consortium of fermentative and methanogenic microorganisms developed from the solid waste digestor of a fully contained, land-based, marine recirculating aquaculture system are described. The methanogenic microbial consortium discovered is capable of reducing over 90% of marine fish waste in... University Of Maryland Baltimore

01/26/17 / #20170021187

Methods and systems for controlling magnetic fields and magnetic field induced current

The present invention discloses methods and systems to control magnetic fields and magnetic field induced currents, and more particularly to provide stimulations within a patient's body, such as deep brain stimulation, in a non-invasive manner and with greater focus and control than has been afforded by prior known methods and... University Of Maryland Baltimore

01/19/17 / #20170014415

Thieno- and pyrrolopyrimidine analogues as anticancer agents and methods of use thereof

The present invention provides for the design and synthesis of halogenated thieno- and pyrrolopyrimidine compounds that exhibit cancer proliferation inhibitory activity and the use thereof for cancer treatment.... University Of Maryland Baltimore

01/12/17 / #20170013213

Turbulence-free camera system and related image enhancement

A turbulence-free CCD camera system with nonclassical imaging resolution, for applications in long-distance imaging, such as satellite and aircraft-to-ground based distant imaging, utilizing an intensity-fluctuation correlation measurement of thermal light. The proposed camera system has the following advantages over classic imaging technology: (1) it is turbulence-free; (2) its spatial resolution... University Of Maryland Baltimore








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