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University Of Massachusetts patents


Recent patent applications related to University Of Massachusetts. University Of Massachusetts is listed as an Agent/Assignee. Note: University Of Massachusetts may have other listings under different names/spellings. We're not affiliated with University Of Massachusetts, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "U" | University Of Massachusetts-related inventors


Recombinant glut1 adeno-associated viral vector constructs and related methods for restoring glut1 expression

The present invention relates to recombinant Glut1 adeno-associated viral vector (rAAV) constructs and related methods for restoring Glut1 expression in Glut1 deficient mammals. In certain embodiments, the rAAV further comprises a chicken β-actin promoter wherein the rAAV is capable of crossing the blood-brain barrier (BBB). In certain embodiments, the present... University Of Massachusetts

Targeting gdf6 and bmp signaling for anti-melanoma therapy

The invention features methods of treating melanoma by modulating an activity of GDF6 in melanoma cells. In one aspect, the methods involve downregulating an activity of GDF6, for example, by using an anti-GDF6 binding molecule, such as an inactivating antibody. Another aspect features treating a subject by first screening for... University Of Massachusetts

Protein transduction domains mimics

The invention generally relates to synthetic mimics of cell penetrating peptides. More particularly, the invention relates to certain novel monomers, oligomers and polymers (e.g., co-polymers) that are useful for the preparation of synthetic mimics of cell penetrating peptides, their compositions, preparations and use.... University Of Massachusetts

Surface-modified macrophages for cell-based delivery

A population of isolated mammalian macrophages, the cell surface of which is chemically modified to comprise a molecule that comprises an imaging agent or a therapeutic agent or a molecule that binds to an imaging agent or a therapeutic agent, and methods of making and using the modified macrophages are... University Of Massachusetts

Compositions and methods for transient delivery of nucleases

The disclosure in some aspects relates to recombinant adeno-associated viruses having nuclease grafted to one or more capsid proteins. In some aspects, the disclosure relates to isolated AAV capsid proteins having terminally grafted nucleases and isolated nucleic acids encoding the same. Recent approaches to delivering nucleases to cells for gene... University Of Massachusetts

Systems and methods for asymmetric backscatter communications

Systems and methods for backscatter communications are provided that employ a backscatter reader to transmit a carrier signal to multiple backscatter tags having heterogeneous hardware and specifications. In response to receiving the carrier, the tags encode data into the received signal and, concurrently, transmit their respective backscattered signal to the... University Of Massachusetts

Nanoparticle-protein complex for intracellular protein delivery

Various embodiments disclosed relate to a nanoparticle-protein complex for intracellular protein delivery. In various embodiments, the present invention provides a nanoparticle-protein complex including a nanoparticle including an amine-containing ligand. The nanoparticle-protein complex also includes a protein comprising a carboxylic acid-containing tag.... University Of Massachusetts

Recombinant aav variants and uses thereof

The disclosure in some aspects relates to recombinant adeno-associated viruses having distinct tissue targeting capabilities. In some aspects, the disclosure relates to gene transfer methods using the recombinant adeno-associated viruses. In some aspects, the disclosure relates to isolated AAV capsid proteins and isolated nucleic acids encoding the same.... University Of Massachusetts

Analogy finder

A user provides a query that includes at least two of a subject, a predicate, and an object. A computer system identifies synonyms of one or more of the subject, predicate, and object, and forms new queries from the identified synonyms. The system searches a dataset using the new queries,... University Of Massachusetts

Fiber surface finish enhanced flocked impact force absorbing structure and manufacturing

Embodiments of fiber surface finish enhanced flocked surface impact force absorbing structure include a plurality of flock fibers disposed on a substrate, a surface coating applied to the plurality of flock fibers, and in another embodiment, a divider fabric bonded to the tops of flock fibers.... University Of Massachusetts

Backside configured surface plasmonic structure for infrared photodetector and imaging focal plane array enhancement

The invention relates to quantum dot and photodetector technology, and more particularly, to quantum dot infrared photodetectors (QDIPs) and focal plane array. The invention further relates to devices and methods for the enhancement of the photocurrent of quantum dot infrared photodetectors in focal plane arrays.... University Of Massachusetts

Cancer immunotherapy

Methods of providing populations of NKT and/or γδ T cells, and their use, e.g., in therapies such as cancer immunotherapy.... University Of Massachusetts

Preparation and application of pb-free nanosolder

The preparation and use of particulate metallic solder alloy having particles of a single chemical composition is described. The particles of the particulate metallic solder alloy have a bimodal size distribution in which particles in a smaller size range have a largest dimension that is smaller than a smallest dimension... University Of Massachusetts

Fully stabilized asymmetric sirna

Provided herein are self-delivering oligonucleotides that are characterized by efficient RISC entry, minimum immune response and off-target effects, efficient cellular uptake without formulation, and efficient and specific tissue distribution.... University Of Massachusetts

Hic: identifying interactions between genomic loci

The disclosed Hi-C protocol can identify genomic loci that are spatially co-located in vivo. These spatial co-locations may include, but are not limited to, intrachromosomal interactions and/or interchromosomal interactions. Hi-C techniques may be applied to many different scales of interest. For example, on a large scale, Hi-C techniques can be... University Of Massachusetts

Systems and methods for backscatter communication

Systems and methods for wireless communication are provided. The systems and methods employ a backscatter tag that is configured to shift an incident carrier signal received by the tag to a different frequency band and then transmitting the frequency-shifted carrier signal to a receiver. The frequency band to which the... University Of Massachusetts

Anthelmintic probiotic compositions and methods

Compositions and methods for treating or reducing the severity or likelihood of occurrence of a parasitic worm or helminth infection in a subject are described. The methods include administering to the subject a therapeutically effective amount of a recombinant bacterium expressing a crystal protein such as a Bacillus thuringiensis crystal... University Of Massachusetts

Cns targeting aav vectors and methods of use thereof

The invention in some aspects relates to recombinant adeno-associated viruses useful for targeting transgenes to CNS tissue, and compositions comprising the same, and methods of use thereof In some aspects, the invention provides methods and compositions for treating CNS-related disorders.... University Of Massachusetts

Polymers and polymeric nanogels with hydrophilics encapsulation and release capabilities and methods thereof

The invention provides pH- or redox-responsive and charge-neutral polymeric nanogels that stably encapsulate a biomolecule at one pH or redox condition and then release it at a different pH or redox condition, and compositions and methods of preparation and use thereof.... University Of Massachusetts

Targeting epigenetic regulators using a bacterial delivery system

One embodiment provides an attenuated Salmonella strain comprising a lysis gene or cassette operably linked to an intracellularly induced Salmonella promoter. In one embodiment, the promoter is a promoter for one of the genes in Salmonella pathogenicity island 2 type III secretion system (SPI2-T3SS) selected from the group SpiC/SsaB, SseF,... University Of Massachusetts

Mapping of genomic interactions

The present invention relates to genomic analysis. In particular, the present invention provides methods and compositions for mapping genomic interactions.... University Of Massachusetts

Ultralow-energy electro-optical logic and nxn switching by resonant on-chip nanobeam waveguide networks

An ultralow-energy electro-optical 2×2 cross-bar switch comprises an identical pair of semiconductor nanobeams that are incorporated in the central arms of a waveguided Mach-Zehnder interferometer. Each nanobeam includes a one dimensional “lattice” of holes along the nanobeam axis that defines a resonant cavity whose fundamental mode is the operating wavelength... University Of Massachusetts

Yeast cell wall particles for receptor-targeted nanoparticle delivery

The present invention generally relates to yeast cell wall microparticles loaded with nanoparticles for receptor-targeted nanoparticle delivery. In particular, the present invention relates to trapping nanoparticles either on the surface or inside a yeast glucan particles, for example, yeast glucal particles. The present invention further relates to methods of making... University Of Massachusetts

Rna interference mediating small rna molecules

Double-stranded RNA (dsRNA) induces sequence-specific post-transcriptional gene silencing in many organisms by a process known as RNA interference (RNAi). Using a Drosophila in vitro system, we demonstrate that 19-23 nt short RNA fragments are the sequence-specific mediators of RNAi. The short interfering RNAs (siRNAs) are generated by an RNase III-like... University Of Massachusetts

Mouse model of alpha-one antitrypsin (aat) deficiency

Transgenic non-human animals, e.g., rodents, e.g., mice comprising genomic mutations that inactive all of the serpinlA genes and thus lack any functional serpinA1 genes. As a result of the genomic mutations, the animals express no hepatic or circulatory AAT protein. Also provided herein are cells and tissues derived from the... University Of Massachusetts

Electrical insulation layer and battery device

An electrical insulation layer including microparticles and having a mesoporous structure; and a battery device including a cathode, an anode, an electrical insulation layer including microparticles and having a mesoporous structure, the electrical insulation layer being arranged between the anode and the cathode, and an ion conductive composition.... University Of Massachusetts

Branched oligonucleotides

Provided herein are branched oligonucleotides exhibiting efficient and specific tissue distribution, cellular uptake, minimum immune response and off-target effects, without formulation.... University Of Massachusetts

Versioning system for network states in a software-defined network

A versioning system for network state of a network includes: a server, configured to execute a versioning controller, the versioning controller being configured to communicate with a plurality of data plane devices of the network and store a plurality of network states in a local non-transitory memory corresponding to the... University Of Massachusetts

Compositions and methods for increasing immunogenicity of glycoprotein vaccines

The present invention relates to the microbial immunogens engineered to bear α-gal epitope(s) for induction of potent humoral and cellular immune responses when administered to subjects having anti-Gal antibodies. In one embodiment, the present invention provides compositions and methods for propagating influenza virus in human, ape, Old World monkey or... University Of Massachusetts

Deoxybenzoin containing flame retardant polymer compositions

The present invention relates to specific deoxybenzoin containing flame retardant polyesters and flame retardant thermoplastic polymer molding compositions comprising deoxybenzoin containing flame retardant polyesters as well as their preparation and use for producing moldings, fibers or foils.... University Of Massachusetts

High capacity easy release extended use adhesive devices

The invention provides novel devices, systems, designs, materials and fabrication methods that enable high-load capacity, easy release, and suitable for extended/repeated use in a variety of applications.... University Of Massachusetts

Devices and methods for measuring vascular deficiency

The present invention relates to devices and methods for measuring vascular deficiency using Doppler ultrasound detection. Embodiments can be used to monitor the condition of surgical tissue flaps or other conditions in which obstruction in the vascular system can impact patient health. The systems can include a Doppler ultrasound probe,... University Of Massachusetts

Surgical retraction device

A surgical appliance includes a pair of opposed prongs slideably disposed on an elongated locking track for retracting neurovascular and musculotendinous anatomical structures through an incision for affording access to deeper structures for inserting osteosynthesis hardware in the surgical treatment of a distal radius fracture or other surgical procedure. The... University Of Massachusetts

Negative pressure wound closure devices and methods

Systems, devices, and methods of the present application can accelerate and reduce medical complications associated with healing of non-planar wounds such as amputation wounds. The devices and methods utilize a collapsing structure and negative pressure to cause the shaped wound to preferentially close. The structure can accommodate movement over curved... University Of Massachusetts

10/05/17 / #20170282147

Nanostructured producing carbon-containing molecules as a renewable energy resource

Nanostructured arrays having a metal catalyst (e.g., cobalt) are irradiated with light to initiate the an artificial photosynthetic reaction resulting in the formation of carbon-containing molecules, for example, long chained hydrocarbons or amino acids. A nanostructure having one or more structural elements having a high aspect ratio can formed over... University Of Massachusetts

09/28/17 / #20170276643

Coulometric microfluidic sensors using a silver band electrode, and methods thereof

The invention provides novel microfluidic coulometric sensors having a silver (Ag) band electrode longitudinally placed in a microchannel affording visual readout suitable for the naked eye, and methods of fabrication and applications thereof.... University Of Massachusetts

09/14/17 / #20170258571

Composite comprising fabric and polyampholyte hydrogel and preparation method thereof

(c) polymerizing monomers in the monomer mixture solution to obtain a precursor of the composite.... University Of Massachusetts

09/14/17 / #20170258796

Methods and compositions to reduce oxidative stress

The invention relates to therapeutic applications for compositions that reduce the level of oxidative stress on cells in vivo or in vitro. The invention describes methods for improving the therapeutic properties of stem cells. The invention also provides combination therapies that are useful to balance the oxidative microenvironment of cells... University Of Massachusetts

09/14/17 / #20170258892

Compositions and methods to treat aids

Polyvalent, primary isolate nucleic acid compositions for inducing an immune response against HIV are disclosed. The compositions and methods described herein are for the use of a nucleic acid composition that encodes one or more different HIV envelope glycoproteins. The synthetic, codon-optimized DNAs encoding one or more HIV proteins are... University Of Massachusetts

09/14/17 / #20170263385

Hydrophilic conjugated polymers, and methods of preparation and use thereof

The invention provides novel hydrophilic conjugated polymers, e.g., hydrophilic poly(arylene vinylenes) or PAVs, and preparation thereof, and methods and devices for their application in photovoltaics, and the resulting improved solar cells.... University Of Massachusetts

08/31/17 / #20170248610

Method of predicting obesity

The presently disclosed subject matter relates to a method for predicting increased risk of obesity on a non-obese subject. More particularly, the presently disclosed subject matter relates to a method of predicting increased risk of obesity in a non-obese subject by determining a level of neurotensin expression in a biological... University Of Massachusetts

08/24/17 / #20170238660

High capacity easy release extended use adhesive closure devices

Unique designs, devices, systems, materials and fabrication methods are provided including adhesive closure devices that are easily released and are suitable for extended/repeated use in a variety of applications.... University Of Massachusetts

08/24/17 / #20170239377

Molecular probes for multimodality imaging and tracking of stem cells

The invention relates to novel multi-modality probes for imaging, tracking and analyzing stem cells and related biological samples, and methods of preparation and use thereof. The molecular probes of the invention are constructed, for example, by utilizing (a) the high selectivity of long hydrocarbon chains for binding to plasma membranes... University Of Massachusetts

08/24/17 / #20170241982

Multi-well quartz crystal microbalance mass and viscoelastic sensor

In an embodiment, a system includes a plurality of sensor devices contained in a plurality of wells contained in a well-plate assembly. The sensor devices are used in a plurality of oscillators. Each oscillator generates a frequency and a resistance based on a quality of living biological cells contained in... University Of Massachusetts

08/17/17 / #20170231587

Apparatus and x-ray-based breast imaging

The invention provides x-ray-based breast imaging systems and related methods that are, for example, applicable to contrast enhanced digital mammography and contrast enhanced digital breast tomosynthesis and allow fast, cost-effective and accurate x-ray imaging.... University Of Massachusetts

08/17/17 / #20170231905

Methods of inhibiting cataracts and presbyopia

Described herein are methods of inhibiting or reversing the progression of cataract formation or presbyopia in an eye by administering a γ-crystallin charge masking agent. Both presbyopia and cataracts are caused by aggregation of the soluble crystalline lens proteins called the crystallins.... University Of Massachusetts

08/10/17 / #20170224703

Antifungal agents and uses thereof

Antimicrobial agents, compositions that include the agent(s) and use(s) thereof are provided. Also disclosed are screening assays for identifying antimicrobial agents.... University Of Massachusetts

08/10/17 / #20170226193

Anti-ospa antibodies and methods of use

The invention provides anti-OspA antibodies and methods of using the same.... University Of Massachusetts

08/03/17 / #20170216450

Crosslinked polymer nano-assemblies and uses thereof

The invention provides a novel system of nano-assemblies and related method for delivery of therapeutic, diagnostic or imaging agent to biological sites. The compositions and methods of the invention enable the syntheses of novel polymeric nano-assemblies (nanoparticles) under non-emulsion conditions with the incorporation of hydrophobic guest molecules. The versatilities and... University Of Massachusetts

08/03/17 / #20170219503

Apparatus and x-ray phase contrast imaging

An x-ray phase contrast imaging apparatus and method of operating the same. The apparatus passes x-rays generated by an x-ray source through, in succession, a source grating, an object of interest, a phase grating, and an analyzer grating. The x-ray source, the source grating, the phase grating, and the analyzer... University Of Massachusetts

07/27/17 / #20170209625

Zwitterionic hydrogels for delivery of biomolecules

The invention provides a novel approach in which zwitterionic networks are used to sequester and deliver ionic biomolecules, such as proteins, without compromising their native conformation and bioactivity. Zwitterionic networks are designed to effectively retain and deliver ionic or polar biomolecules for guided tissue regeneration. The invention represents a conceptual... University Of Massachusetts

07/13/17 / #20170197371

Method and making a composite

Various embodiments disclosed relate to methods and apparatuses for forming composites. In various embodiments, the present invention provides a method of making a composite. The method can include placing a resin-impregnated fiber on a tooling surface. The method can include at least partially curing the resin-impregnated fiber. The method can... University Of Massachusetts

07/06/17 / #20170188823

Eye tracker system and methods for detecting eye parameters

An improved eye tracker system and methods for detecting eye parameters including eye movement using a pupil center, pupil diameter (i.e., dilation), blink duration, and blink frequency, which may be used to determine a variety of physiological and psychological conditions. The eye tracker system and methods operates at a ten-fold... University Of Massachusetts

07/06/17 / #20170189239

Surgical cavity drainage and closure system

The device also can include a coating of surgical adhesive and a tissue anchoring system of hooks or barbs. The device can be used with a negative pressure system to further improve the drainage band can also be used with a wound dressing. The device and systems containing the device... University Of Massachusetts

07/06/17 / #20170191039

Recombinant aavs having useful transcytosis properties

The disclosure in some aspects relates to recombinant adeno-associated viruses having distinct tissue targeting capab- lities. In some aspects, the disclosure relates to gene transfer methods using the recombinant adeno-associate viruses. IN some as- pects, the disclosure relates to isolated AAV capsid proteins and isolated nucleic acids encoding the same.... University Of Massachusetts

07/06/17 / #20170191893

Optical fiber pressure sensor with uniform diaphragm and fabricating same

An optical fiber sensor can be used to measure pressure with high sensitivity and fine resolution. As a cavity at the end of the sensor expands or contracts, the spectrum of a beam reflected from the end of fiber shifts, producing a change linked to pressure exerted on the sensor.... University Of Massachusetts

07/06/17 / #20170193339

Feature type spectrum technique

Sensors are used to generate sample set data representing objects in a sample set. A computer system analyzes the sample set data to determine the frequencies with which features in a feature set are observed in the objects in the sample set. An example of such output is a bar... University Of Massachusetts

06/29/17 / #20170182220

Degradable hydrogel with predictable tuning of properties, and compositions and methods thereof

The invention provides a novel approach to hydrogels with predictable degradation/gelling kinetics, which is useful for many biomedical applications where appropriate gelling kinetics and the timely disintegration of the hydrogel (e.g., drug delivery, guided tissue regeneration) is required. Precisely controlling hydrogel degradation over a broad range in a predictable manner... University Of Massachusetts

06/29/17 / #20170183686

Exosomal loading using hydrophobically modified oligonucleotides

In one aspect, the invention relates to a method of loading exosomes with oligonucleotide cargo, by incubating an oligonucleotide comprising one or more hydrophobic modifications with a population of exosomes for a period of time sufficient to allow loading of the exosomes with the oligonucleotide. Exosomes loaded with hydrophobic ally... University Of Massachusetts

06/29/17 / #20170183741

Treating chronic myelogenous leukemia (cml)

Methods for treating chronic myeloid leukemia (CML), e.g., BCR-ABL inhibitor imatinib mesylate (IM)-resistant CML, using combination treatments, e.g., combined treatment with a BCR-ABL inhibitor, e.g., IM, and a MEK inhibitor, e.g., trametinib.... University Of Massachusetts

06/29/17 / #20170184730

Detectors, detecting ionizing radiation using high energy current

Detectors, a system and a method for detecting ionizing radiation are provided. In some aspects, a detector includes a first layer comprising a first conducting material, and a second layer comprising a second conducting material, wherein at least one of the first layer and second layer is configured to produce... University Of Massachusetts

06/22/17 / #20170179391

Organic photovoltaic devices and methods thereof

The invention provides a novel fabrication method to produce solar cells using water-based inks that can be readily used in roll-to-roll processing, ink-jet printing and other large-scale fabrication processes. The invention also provides OPV devices with significantly improved efficiency. The invention offers a number of advantages over existing methods: (1)... University Of Massachusetts

06/15/17 / #20170165116

Negative pressure wound closure devices and methods

Systems, devices, and methods of the present application can accelerate and reduce medical complications associated with healing of amputation wounds. The devices and methods utilize a compression structure and negative pressure to cause the amputation wound to preferentially close from the deepest portion of the wound to the shallowest portion.... University Of Massachusetts

06/15/17 / #20170165377

Isolation of novel aav's and uses thereof

The invention in some aspects relates to isolated nucleic acids, compositions, and kits useful for identifying adeno-associated viruses in cells. In some aspects, the invention provides kits and methods for producing somatic transgenic animal models using recombinant AAV (rAAV) to an animal having at least one transgene that expresses a... University Of Massachusetts

Patent Packs
06/15/17 / #20170166925

Recombinant aav vectors useful for reducing immunity against transgene products

The disclosure in some aspects, relates to nucleic acids, compositions and kits useful for gene therapy with reduced immune response to transgene products.... University Of Massachusetts

06/15/17 / #20170166927

Isolation of novel aav's and uses thereof

The invention in some aspects relates to isolated nucleic acids, compositions, and kits useful for identifying adeno-associated viruses in cells. In some aspects, the invention provides kits and methods for producing somatic transgenic animal models using recombinant AAV (rAAV) to an animal having at least one transgene that expresses a... University Of Massachusetts

06/08/17 / #20170157243

Manf as a regulator of immune system function

Methods and compositions for enhancing an immunological response by administering an immunogenic composition comprising an effective amount of a MANF family protein or fragment thereof and an antigen to a subject. Also, methods and compositions for decreasing an immune response by inhibiting or antagonizing the activity of a MANF family... University Of Massachusetts

06/08/17 / #20170159071
05/25/17 / #20170144889

Fast production of high quality graphene by liquid phase exfoliation

A method of exfoliating graphite into graphene uses a sequence of flow and sonication on graphite suspensions. Graphite particles after intense mixing/grinding in a liquid are found to be altered, graphite having curled-up edges, which increases its sensitivity to ultrasound. Quadrupled graphene yield is achieved through introducing chaotic flow pretreatment.... University Of Massachusetts

05/25/17 / #20170145439

Multicistronic expression constructs

Some aspects of this invention provide nucleic acid constructs for transgene expression. Some aspects of this invention provide multicistronic nucleic acid constructs, for example, comprising an expression cassette encoding a hairpin RNA and a reporter expression cassette. Some aspects of this invention provide nucleic acid constructs comprising two or more... University Of Massachusetts

05/25/17 / #20170146453

Single channel terahertz endoscopy

A terahertz endoscopic system including a flexible waveguide and system optics. The waveguide is configured to transmit terahertz radiation from a first end of the waveguide to a second end of the waveguide proximate to a sample, and transmit reflected terahertz radiation from the second end of the waveguide to... University Of Massachusetts

05/18/17 / #20170135646

Hyperspectral imaging for prediction of skin injury after exposure to thermal energy or ionizing radiation

The invention provides hyperspectral imaging-based methods that enable effective, efficient and non-invasive detection and characterization of thermal and ionizing radiation exposure in tissue. The methods allow for complete visualization and quantification of oxygenation and perfusion changes in thermal burn or ionizing radiation impacted skin and enables rapid identification of individuals... University Of Massachusetts

05/18/17 / #20170135972

Methods of inhibiting cataracts and presbyopia

Described herein are methods of inhibiting or reversing the progression of cataract formation or presbyopia in an eye by administering a bifunctional molecule comprising a substituted or unsubstituted amine, succinimide, carboxylic acid, isocyanate, isothiocyanate, sulfonyl chloride, aldehyde, carbodiimide, acyl azide, anhydride, fluorobenzene, carbonate, N-hydroxysuccinimide ester, imidoester, epoxide or fluorophenyl ester... University Of Massachusetts

05/11/17 / #20170133525

Infrared absorption by crystalline silicon, compositions and methods thereof

The invention provides a novel method for fabrication of IR-absorbing silicon substrate in ambient atmosphere without the need for special background gases, and compositions and methods of preparation and use thereof.... University Of Massachusetts

05/04/17 / #20170122963

Method for the comparison of protein higher order structures

Some aspects of the disclosure include methods for comparing the higher order structures (HOS) of proteins using covalent labeling agents which allow for the direct comparison of changes in the HOS of protein therapeutics using mass spectrometry. The inventive methods can be used to access the effect of changing the... University Of Massachusetts

04/27/17 / #20170114340

Raav-based compositions and methods for treating amyotrophic lateral sclerosis

The invention relates to inhibitory nucleic acids and rAAV-based compositions, methods and kits useful for treating Amyotrophic Lateral Sclerosis.... University Of Massachusetts

04/20/17 / #20170110642

Folded multi-layered 2-d van der waals materials as efficient thermoelectric converters, and methods thereof

The invention provides thermoelectric devices based on folded, multi-layered nanomembranes prepared from 2-dimensional van der Waals materials, and compositions and methods of preparation and use thereof.... University Of Massachusetts

04/13/17 / #20170101640

Modulation of human cytomegalovirus replication by micro-rna 132 (mir132), micro-rna 145 (mir145) and micro-rna 212 (mir212)

The present invention relates to miR145, miR132, miR212, and the genes or gene products regulated by these miRNAs. miR145 is downregulated in cells infected with HCMV. This downregulation modulates expression of miR145 target genes, including IRS-1. Transfection of cells with a miR145 agent, such as a miR145 mimetic, reduces HCMV... University Of Massachusetts

04/13/17 / #20170101645

Compositions and methods for modulating dysferlin expression

Aspects of the disclosure relate to methods of altering RNA splicing in a subject. In some embodiments, methods are provided for correcting splicing in a cell that contains a DYSF gene having a mutation that results in defective splicing.... University Of Massachusetts

Patent Packs
04/06/17 / #20170096121

Retrofit seat belt system

Systems and methods for installing retrofit seat belt systems with structural support for the lap and shoulder belts, while at the same time providing a low cost solution. In particular, some, or all of the loads, as required, are shared by an added support structure connected rigidly to a structural... University Of Massachusetts

04/06/17 / #20170096664

Spinal muscular atrophy (sma) treatment via targeting of smn2 splice site inhibitory sequences

The present invention is directed to methods and compositions capable of blocking the inhibitory effect of a newly-identified intronic inhibitory sequence element, named ISS-N1 (for “intronic splicing silencer”), located in the SMN2 gene. The compositions and methods of the instant invention include oligonucleotide reagents (e.g., oligoribonucleotides) that effectively target the... University Of Massachusetts

03/23/17 / #20170081664

Targeting hepatitis b virus (hbv) host factors

Described herein are methods of identifying host factors that modulate Hepatitis B virus (HBV) replication in mammalian, e.g., human cells, as well as factors identified by those methods, and methods of treating HBV infections by targeting those factors. Zinc finger, CCHC domain containing 14 (ZCCHC14) is an exemplary host factor.... University Of Massachusetts

03/23/17 / #20170084764

Backside configured surface plasmonic structure for infrared photodetector and imaging focal plane array enhancement

The invention relates to quantum dot and photodetector technology, and more particularly, to quantum dot infrared photodetectors (QDIPs) and focal plane array. The invention further relates to devices and methods for the enhancement of the photocurrent of quantum dot infrared photodetectors in focal plane arrays.... University Of Massachusetts

03/09/17 / #20170065720

Compositions and methods for delivering agents to the central nervous system

The invention in some aspects provides compounds useful for targeting bacterial infections. In some embodiments, the compounds comprise a transferrin receptor ligand covalently linked to a bactericidal agent. In some embodiments, the bactericidal agent is a bactericidal peptide, such as a glycoside hydrolase (e.g., lysozyme).... University Of Massachusetts

03/09/17 / #20170067821

Fourier domain terahertz coherence tomography (tct)

A single-shot terahertz imaging system including an interferometer and a terahertz spectrometer. The interferometer includes a beam splitter configured to receive input terahertz radiation and output first terahertz radiation and second terahertz radiation, a sample configured to reflect the first terahertz radiation, and a mirror configured to reflect the second... University Of Massachusetts

03/09/17 / #20170068725

Analogy finder

A user provides a query that includes at least two of a subject, a predicate, and an object. A computer system identifies synonyms of one or more of the subject, predicate, and object, and forms new queries from the identified synonyms. The system searches a dataset using the new queries,... University Of Massachusetts

02/23/17 / #20170050991

Substituted angular bistetracenes and substituted angular bisoligoacenes and electronic devices made with same

We report the synthesis and characterization of novel bistetracenes, an unconventional, linearly extended conjugated core with eight fused rings. Also described are bisoligoacenes. In general, the properties and stability of large polycyclic aromatic hydrocarbons (PAHs) strongly depend on the mode of ring annellation and the topology of their it-electron systems,... University Of Massachusetts

02/23/17 / #20170051283

Rna interference for the treatment of gain-of-function disorders

The present invention relates to the discovery of an effective treatment for a variety of gain-of-function diseases, in particular, Huntington's disease (HD). The present invention utilizes RNA Interference technology (RNAi) against polymorphic regions in the genes encoding various gain-of-function mutant proteins resulting in an effective treatment for the gain-of-function disease.... University Of Massachusetts

02/23/17 / #20170053079

System and methods for scoring data to differentiate between disorders

A clinical scoring system and methods that effectively and efficiently utilizes a number of different data sources to determine a diagnosis of patient conditions. The score is compared to a spectrum of scores in order to identify between disorders, such as Inflammatory bowel disease (IBD) and irritable bowel syndrome (IBSd)... University Of Massachusetts

02/16/17 / #20170043024

Bioactive conjugates for oligonucleotide delivery

Provided herein are self-delivering oligonucleotides that are characterized by efficient RISC entry, minimum immune response and off-target effects, efficient cellular uptake without formulation, and efficient and specific tissue distribution.... University Of Massachusetts

02/16/17 / #20170047520

Functional interlayers of fullerene derivatives and applications in organic solar cells

The invention provides novel materials, methods and designs to enable improved power conversion efficiencies of organic photovoltaics (OPVs). In particular, the invention provides novel materials and interlayers for polymer-based solar cells. Novel functional fullerene-based interlayers are disclosed that enable high efficiency devices in conjunction with numerous active layer and electrode... University Of Massachusetts

02/09/17 / #20170035691

Food matrices and methods of making and using

A method of these teachings for designing foods in order to improve the bioavailability of orally administered bioactive agents, the method including designing a food matrix, the food matrix not having bioactivity above its normal nutritional function, that increases bioavailability of a predetermined pharmaceutical or nutraceutical by at least one... University Of Massachusetts

02/09/17 / #20170035837

Compositions and methods for treating disease using salmonella t3ss effector protein (sipa)

The invention provides compositions and methods for reducing one or more symptoms of disease by administering compositions comprising SipA. The invention's compositions and methods are particularly advantageous in reducing symptoms of diseases that are associated with overexpression of P-gp and/or p53. The invention's compositions and methods are useful in reducing... University Of Massachusetts

02/09/17 / #20170036241

Methods and formulations for durable superhydrophic, self-cleaning, and superhydrophobic polymer coatings and objects having coatings thereon

An object has a durable superhydrophic, self-cleaning, and icephobic coating includes a substrate and a layer disposed on the substrate, the layer resulting from coating with a formulation having an effective amount of hierarchical structuring micro/nanoparticles, liquid silane having one or more groups configured to graft to a hierarchical structuring... University Of Massachusetts

02/02/17 / #20170028103

Compositions and methods for surface mineralization

The invention provides novel compositions and methods of surface mineralization for metallic or ceramic implants and devices and the resulting enhancement of properties and performance in skeletal tissue engineering, orthopedic applications and dental care. The novel approach utilizes zwitterionic brushes (e.g., of poly(sulfobetaine methacrylate) or pSBMA) covalently grafted on the... University Of Massachusetts

02/02/17 / #20170029838

Plant biomass yield increase by modified swam1 gene expression

Provided herein are plants and methods to increase plant biomass, for example, a transgenic plant, plant cell, plant part or seed, wherein the transgenic plant, plant cell, plant part or seed comprises a heterologous promoter which increases expression of SWAM1, other genes related to SWAM1, or GNRF, as compared to... University Of Massachusetts

01/19/17 / #20170014547

Amphiphilic degradable polymers for immobilization and sustained delivery of biomolecules

The invention provides a novel approach to controlled delivery of biomolecules (e.g., lipids and proteins) by employing novel amphiphilic polymers that are effective delivery vehicles. These unique amphiphilic polymers may be employed as controlled delivery vehicles or tissue engineering scaffolds wherein the delivery of lipophilic or amphiphilic bioactive molecules can... University Of Massachusetts

01/12/17 / #20170009090

Ferroelectric nanocomposite based dielectric inks for reconfigurable rf and microwave applications

A novel ferroelectric ink comprising multiphase Barium Strontium Titanate (BST) in a polymer composite is described. The ink can be employed using direct-ink writing techniques to print high dielectric constant, low loss, and electrostatically-tunable dielectrics on substrates. The substrates can be flexible such as plastics or rigid, such as substrates... University Of Massachusetts

12/21/17 / #20170362269

Novel neisseria gonorrhoeae therapeutic based on cmp-nonulosonate sugars

N. gonorrhoeae has become resistant to almost every conventional antibiotic. Described herein is the use of CMP-nonulosonate analogues to counter gonococcal complement evasion. The nonulosonate sugar is incorporated into the lipooligosaccharide of the N. gonorrhoeae which in turn reduces the serum resistance of the bacteria. This provides a novel therapeutic... University Of Massachusetts

06/22/17 / #20170172411

Methods and systems for reducing irritability in infants

Systems and methods according to the present concepts reduce irritability in infants, such as infants suffering from neonatal abstinence syndrome (NAS) or colic. According to one embodiment, a method for reducing irritability in an infant includes determining one or more physiological measurements from an infant. The one or more physiological... University Of Massachusetts








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