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University Of Notre Dame Du Lac
University Of Notre Dame Du Lac Office Of Technology Transfer
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University Of Notre Dame Du Lac patents


Recent patent applications related to University Of Notre Dame Du Lac. University Of Notre Dame Du Lac is listed as an Agent/Assignee. Note: University Of Notre Dame Du Lac may have other listings under different names/spellings. We're not affiliated with University Of Notre Dame Du Lac, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "U" | University Of Notre Dame Du Lac-related inventors


Potentiators of beta-lactam antibiotics

We disclose herein that the BlaR1 protein of methicillin-resistant Staphylococcus aureus (MRSA), an antibiotic sensor/signal transducer, is phosphorylated on exposure to β-lactam antibiotics. This event is critical for the onset of the biochemical events that unleash induction of antibiotic resistance. The BlaR1 phosphorylation and the antibiotic-resistance phenotype are abrogated in... University Of Notre Dame Du Lac

Method for preparing largazole analogs and uses thereof

Analogs of largazole are described herein. Methods of treating cancer and blood disorders using largazole and largazole analogs and pharmaceutical compositions comprising the same are additionally described herein. Methods for preparing largazole analogs are likewise described.... University Of Notre Dame Du Lac

Quinazolinone antibiotics

A new class of antibiotics effective against methicillin-resistant Staphylococcus aureus (MRSA) is disclosed. Compounds of this class can impair cell-wall biosynthesis by binding to both the allosteric and the catalytic domains of penicillin-binding protein (PBP) 2a. This class of antibiotics holds promise in reversing obsolescence of staphylococcal PBPs as important... University Of Notre Dame Du Lac

Method and apparatus of plasma flow control for drag reduction

A plasma plate is used to minimize drag of a fluid flow over an exposed surface. The plasma plate includes a series of plasma actuators positioned on the surface. Each plasma actuator is made of a dielectric separating a first electrode exposed to a fluid flow and a second electrode... University Of Notre Dame Du Lac

System for capillary electrophoresis for peptide and protein analysis

The invention provides a novel method of coating the inside of a capillary with a polymeric material. The method can include introducing a catalyst-free solution of a monomer and initiator, wherein the monomer is present in about 1-10% (w/v) and the initiator is present in 0.1-1% (w/v), into a capillary... University Of Notre Dame Du Lac

Peripherally substituted monocyclic beta-lactams

The invention provides monobactams that can be used as antibacterial agents or intermediates for the preparation of other useful compounds such as antibacterial agents.... University Of Notre Dame Du Lac

Enhanced cosite transmitter-receiver isolation

Systems and methods for improving isolation between a cosite transmitter-receiver system. The transmitter may send a first plurality of transmit signals from multiple transmit ports. The first plurality of transmit signals may be related to one another by a first set of complex weights. The receiver may detect channel-impaired versions... University Of Notre Dame Du Lac

Linear combinations of transmit signals by a receiver

A multi-port transmitter can synthesize and send a first plurality of transmit signals having a separability characteristic which permits them to be differentiated from one another. A receiver can then detect one or more receiver signals which include one or more combinations of received versions of the first plurality of... University Of Notre Dame Du Lac

Additive manufacturing device for biomaterials

An additive manufacturing (AM) device for biomaterials comprises a reservoir, a shaft, and a material delivery head. The device can be used for intracorporeal additive manufacturing. Material within the reservoir can be expelled by a mechanical transmission element, for example a syringe pump, a peristaltic pump, an air pressure pump,... University Of Notre Dame Du Lac

Acceleration of diabetic wound healing

The invention provides compounds, compositions, and methods to improve or accelerate the healing of a wound. In various embodiments, the methods can include the topical treatment of the wound with the enzyme MMP-8, or the topical treatment of the wound with MMP-8 in combination with administration of an MMP-9 inhibitor,... University Of Notre Dame Du Lac

Adjustable connection for structural members

An adjustable structural connection—a connection which can be adjusted to alter the location and angle of member attachment—transforms the traditional notion of connections as a static means of connecting members at specific angles to a dynamic means of assembling a variety of structurally efficient forms. The adjustable connection connects a... University Of Notre Dame Du Lac

Adjustable bolted steel plate connection

An adjustable structural connection can be used to join steel structural elements at a range of angles and is capable of adjusting in situ to accommodate additional angles or tolerances through cold bending. Pre-bent plate or plates may be loosely fitted around steel structural elements, such that holes in the... University Of Notre Dame Du Lac

Exosomal biomarkers diagnostic of tuberculosis

The disclosure provides a method for diagnosing an active mycobacterium tuberculosis infection by detecting certain RNA biomarkers present in secreted extracellular vesicles isolated from a bodily fluid. The RNA biomarkers in the secreted extracellular vesicles may include a certain mycobacterium RNAs as well as certain host cell RNAs. Also provided... University Of Notre Dame Du Lac

Methods and spin wave-based spectrum analyzers

An example device includes a magnetic film, two or more spin wave generators, and one or more detectors. The magnetic film is capable of supporting spin waves. The two or more spin wave generators are operable to create a diffraction pattern of the spin waves in the magnetic film. The... University Of Notre Dame Du Lac

Inter-chip alignment

First, second, and third integrated devices each include one or more interconnecting structure. Each interconnecting structure includes (i) one or more interconnecting nodules extending from an edge surface of the device, (ii) one or more interconnect voids formed in an edge surface of the device, or (iii) both (i) and... University Of Notre Dame Du Lac

Ion transport in binary-salt ionic liquids

The viscosity of various ionic liquids (IL), the solvent tetraethylene glycol dimethyl ether (G4), and their mixtures, with or without lithium salts, were measured experimentally. Various compositions were studied spectroscopically. Detailed analysis reveals that G4 preferentially solvates cations, leading to a reduction in the interaction energy between cations and anions... University Of Notre Dame Du Lac

Selective matrix metalloproteinase inhibitors

The invention provides compounds, compositions, and methods for the treatment of diseases, disorders, or conditions that are modulated by matrix metalloproteinases (MMPs). The compounds can be selective MMP inhibitors, for example, selective inhibitors of MMP-2, MMP-9, and/or MMP-14. The disease, disorder, or condition can include, for example, stroke, neurological disorders,... University Of Notre Dame Du Lac

Inter-chip alignment

First and second integrated devices each have an optical component and a plurality of interconnect structures disposed one edge thereon. The first edge surface of the second integrated device is positioned contiguous to the first edge surface of the first integrated device. The interconnect structures disposed on the first integrated... University Of Notre Dame Du Lac

Methods and pulsed-dc dielectric barrier discharge plasma actuator and circuit

A plasma generating device intended to induce a flow in a fluid via plasma generation includes a dielectric separating two electrodes and a power supply. The first electrode is exposed to a fluid flow while the second electrode is positioned under the dielectric. The power supply is electrically coupled to... University Of Notre Dame Du Lac

Antibody purification via affinity chromatography

Embodiments herein provide methods of purifying monoclonal and polyclonal anti-bodies (e.g., immunoglobulins) from biological fluids, such as cell lysates, cell supernatant and ascites fluids, using small molecule affinity chromatography. Various embodiments disclose a class of small molecules that selectively bind a nucleotide binding site that is inherent to all immunoglobulins,... University Of Notre Dame Du Lac

Group iii-nitride compound heterojunction tunnel field-effect transistors and methods for making the same

A tunnel field-effect transistor device includes a p-type GaN source layer, an n-type GaN drain layer, and an interlayer interfaced between the source-layer and the drain layer. In one example, the interlayer includes an Indium Nitride (InN) layer. In one example, the interlayer includes a graded Indium gallium nitride layer... University Of Notre Dame Du Lac

Group iii-nitride compound heterojunction tunnel field-effect transistors and methods for making the same

A tunnel field-effect transistor device includes a p-type GaN source layer, an ntype GaN drain layer, and an interlayer interfaced between the source-layer and the drain layer. These devices employ polarization engineering in GaN/InN heterojunctions to achieve appreciable interband tunneling current densities. In one example, the interlayer includes an Indium... University Of Notre Dame Du Lac

Integrated membrane sensor for rapid molecular detection

Disclosed are methods, compositions, and devices for an integrated, heterogenerous ion-exchange membrane-based plastic microfluidic biochip platform that can be used to detect multiple diagnostic markers present in real samples. Its various components can be easily integrated in a modular fashion for different applications. Automated control allows sequential and dynamic activation... University Of Notre Dame Du Lac

Adjustable modules for variable depth structures

This disclosure presents a new strategy for modular construction: an adjustable module. This disclosure develops a new adjustable module comprised of a four-bar linkage which can form more efficient variable depth structures. Applications can include rapidly erectable bridges, roofs, buildings, and grid shells, among others. This disclosure provides specific detail... University Of Notre Dame Du Lac

Systems and methods for filtering and computation using tunnelling transistors

An electrical circuit is disclosed that comprises plurality of tunneling field-effect transistors (TFETs) arranged in a diffusion network matrix having a plurality of nodes wherein, for each of the TFETs that is not on an end of the matrix, a drain of the TFET is electrically coupled with the source... University Of Notre Dame Du Lac

Two-dimensional heterojunction interlayer tunneling field effect transistors

A two-dimensional (2D) heterojunction interlayer tunneling field effect transistor (Thin-TFET) allows for particle tunneling in a vertical stack comprising monolayers of two-dimensional semiconductors separated by an interlayer. In some examples, the two 2D materials may be misaligned so as to influence the magnitude of the tunneling current, but have a... University Of Notre Dame Du Lac

Mixed signal processors

Various processor architectures for mixed signal computation exploit the unique characteristics of advanced CMOS technologies, such as fin-based, multi-gate field effect transistors, and/or emerging technologies such as tunnel field effect transistors (TFETs). The example processors disclosed herein are cellular neural network (CNN)-inspired and eliminate the need for voltage controlled current... University Of Notre Dame Du Lac

Selective matrix metalloproteinase inhibitors

The invention provides compounds, compositions, and methods for the treatment of diseases, disorders, or conditions that are modulated by matrix metalloproteinases (MMPs). The compounds can be selective MMP inhibitors, for example, selective inhibitors of MMP-2, MMP-9, and/or MMP-14. The disease, disorder, or condition can include, for example, stroke, neurological disorders,... University Of Notre Dame Du Lac

Glass catalyst compositions for improved hydrothermal durability

A diesel soot filter includes a substrate having a surface disposed at least partially within a fluid path of the diesel soot filter. A glass catalyst is disposed on the surface of the substrate such that an exhaust gas contacts at least a portion of a surface of the glass... University Of Notre Dame Du Lac

Use of coherent signal dispersion for signal source association

A signal source association method and receiver. A receiver can be used to detect a plurality of signals transmitted from a plurality of transmission sources. The receiver can determine amplitude and phase information for a plurality of frequency components of each of the plurality of signals. The receiver can also... University Of Notre Dame Du Lac

Systems and methods for guided de-noising for computed tomography

A method includes obtaining spectral computed tomography (CT) information via an acquisition unit having an X-ray source and a CT detector. The method also includes, generating, with one or more processing units, using at least one image transform, a first basis image and a second basis image using the spectral... University Of Notre Dame Du Lac

Space-polarization modulated communications

Methods and systems relating to topics in space-polarization modulated communications. The topics include: adaptive space-polarization modulated communications using channel state information at the transmitter; adaptive decision boundaries at the receiver; carrier frequency offset estimation for multi-carrier modulation schemes; transmission of analog images using polarization and coherence dispersion information; and reduction... University Of Notre Dame Du Lac








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