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University Of Pittsburgh Of The Commonwealth System Of Higher Education
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University Of Pittsburgh Of The Commonwealth System Of Higher Education patents


Recent patent applications related to University Of Pittsburgh Of The Commonwealth System Of Higher Education. University Of Pittsburgh Of The Commonwealth System Of Higher Education is listed as an Agent/Assignee. Note: University Of Pittsburgh Of The Commonwealth System Of Higher Education may have other listings under different names/spellings. We're not affiliated with University Of Pittsburgh Of The Commonwealth System Of Higher Education, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "U" | University Of Pittsburgh Of The Commonwealth System Of Higher Education-related inventors


Biodegradable metal alloys

The invention relates to biodegradable, metal alloy-containing compositions, methods for their preparation and applications for their use. The compositions include magnesium and other components, such as yttrium, calcium, silver, cerium, and zirconium; or zinc, silver, cerium, and zirconium; or aluminum, zinc, calcium, manganese, silver, yttrium; or strontium, calcium, zinc. The... University Of Pittsburgh Of The Commonwealth System Of Higher Education

Treatment of pulmonary and other conditions

Also disclosed are method for treating pulmonary conditions and other organ or system conditions with the compounds.... University Of Pittsburgh Of The Commonwealth System Of Higher Education

Double component mandrel for electrospun stentless, multi-leaflet valve fabrication

Provided herein is a mandrel for use in electrospinning prosthetic valve devices. Also provided are prosthetic valve devices for implantation in an animal or a human. Methods of making and using the valve devices are also provided herein.... University Of Pittsburgh Of The Commonwealth System Of Higher Education

Retrievable self-expanding non-thrombogenic low-profile percutaneous atrioventricular valve prosthesis

An atrioventricular prosthesis device is provided. The device includes a frame at least partially defining and enclosing a central cavity, the frame having a distal portion, a proximal portion, and a middle portion connected therebetween. The device further includes a valve construct formed, at least in part, from a cell... University Of Pittsburgh Of The Commonwealth System Of Higher Education

Compositions and methods for treating respiratory injury or disease

a pharmaceutically acceptable carrier, excipient, or diluent.... University Of Pittsburgh Of The Commonwealth System Of Higher Education

Bone augmentation utilizing muscle-derived progenitor compositions, and treatments thereof

The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment non-soft tissue following introduction (e.g. via injection, transplantation, or implantation) into a site of non-soft tissue (e.g. bone). Also provided are methods of isolating muscle-derived progenitor cells, and methods of... University Of Pittsburgh Of The Commonwealth System Of Higher Education

Activatable crispr/cas9 for spatial and temporal control of genome editing

Disclosed herein is a genetically encoded light- or chemically-activated Cas9 engineered through the site-specific installation of an activatable lysine amino acid. Such activatable Cas9 proteins can be used in CRISPR/Cas9 systems to control gene expression temporally, spatially, or both. Systems, methods, kits, and compositions for manipulation of sequences and/or activities... University Of Pittsburgh Of The Commonwealth System Of Higher Education

E. coli separatome-based protein expression and purification platform

Provided is a separatome-based peptide, polypeptide, and protein expression and purification platform based on the juxtaposition of the binding properties of host cell genomic peptides, polypeptides, and proteins with the characteristics and location of the corresponding genes on the host cell chromosome of E. coli. The separatome-based protein expression and... University Of Pittsburgh Of The Commonwealth System Of Higher Education

Methods and compositions for diagnosis and prognosis of renal injury and renal failure

It is an object of the present invention to provide methods for assessing the efficacy of a remote ischemic preconditioning procedure though the measurement of urinary TIMP-2 and IGFBP7 concentrations.... University Of Pittsburgh Of The Commonwealth System Of Higher Education

Oxide interface displaying electronically controllable ferromagnetism

A structure includes an electronically controllable ferromagnetic oxide structure that includes at least three layers. The first layer comprises STO. The second layer has a thickness of at least about 3 unit cells, said thickness being in a direction substantially perpendicular to the interface between the first and second layers.... University Of Pittsburgh Of The Commonwealth System Of Higher Education

Wearable cardiac electrophysiology measurement devices, software, systems and methods

Disclosed are wearable devices, such as rings and bracelets, for monitoring and diagnosing cardiovascular conditions of a wearer, along with related systems, algorithms and methods. The disclosed wearable devices can continuously monitor the wearer's cardiovascular status by measuring heart rate, motion, blood oxygenation, and/or other properties of the wearer. Disclosed... University Of Pittsburgh Of The Commonwealth System Of Higher Education

Electrocardiographic identification of non-st elevation ischemic events

Disclosed herein are methods, systems, and devices for identifying increased likelihood of non-ST elevation myocardial infarction (NSTEMI) in a patient based on ECG data. The methods can include determining based on the ECG data that the patient lacks ST elevation (STE) and that the patient exhibits a ventricular repolarization dispersion... University Of Pittsburgh Of The Commonwealth System Of Higher Education

Elastomer coupled with bioactive fatty acid

each R1 is the same or different and is a moiety derived from an unsaturated fatty acid, a dicarboxylic acid, or a dicarboxylic acid-terminated polymer.... University Of Pittsburgh Of The Commonwealth System Of Higher Education

Use of eomesodermin to determine risk of allograft rejection

Pre-existing alloreactive memory T cells are a major barrier to the induction of allograft tolerance in organ transplant recipients. The use of Eomesodermin (Eomes) expression in memory T cells to determine the risk of allograft rejection in a subject is described. Also described is the use of Eomes expression in... University Of Pittsburgh Of The Commonwealth System Of Higher Education

Thioflavin derivatives for use in antemortem diagnosis of alzheimer's disease and in vivo imaging and prevention of amyloid deposition

This invention relates to novel thioflavin derivatives, methods of using the derivatives in, for example, in vivo imaging of patients having neuritic plaques, pharmaceutical compositions comprising the thioflavin derivatives and method of synthesizing the compounds. The compounds find particular use in the diagnosis and treatment of patients having diseases where... University Of Pittsburgh Of The Commonwealth System Of Higher Education

Acyl-coa dehydrogenases micro/nano enzyme assay

Provided herein are methods of measuring acyl-CoA dehydrogenase activity in a biological sample in a multiwell microplate setting.... University Of Pittsburgh Of The Commonwealth System Of Higher Education

Artificial cell constructs for cellular manipulation

The present invention contemplates induction of immunological tolerance thereby providing permanent allograft acceptance. This method obviates the need for a lifelong regimen of immunosuppressive agents which can increase the risk of infection, autoimmunity, and cancer. Immunological tolerance is thought to be mediated by regulatory T lymphocytes (Treg cells) with immunosuppressive... University Of Pittsburgh Of The Commonwealth System Of Higher Education

Griffithsin mutants

The invention provides modified griffithsin polypeptides comprising the amino acid sequence of SEQ ID NO: 1, as well as corresponding nucleic acids, vectors, cells, fusion proteins, constructs, conjugates, and methods of inhibiting viral infection.... University Of Pittsburgh Of The Commonwealth System Of Higher Education

Fatty acids as anti-inflammatory agents

where a, b, c, d, e, f, V, W, X, Y, Ra, Ra′, Rb, Rb′, Rc, and Rc′ are defined herein. In particular, the compounds of the invention are candidate therapeutics for treating inflammatory conditions.... University Of Pittsburgh Of The Commonwealth System Of Higher Education

Tetrahydroisoquinolines as selective nadph oxidase 2 inhibitors

wherein “” represents a single or double bond, R1 is hydrogen, halogen, lower aliphatic, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; Ra is hydrogen, —CH2R2, R3, or —SO2R4; R2 is lower aliphatic, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; R3 is substituted or unsubstituted aryl, or... University Of Pittsburgh Of The Commonwealth System Of Higher Education

Calcium channel agonists

wherein each bond depicted as “” is a single bond or a double bond as needed to satisfy valence requirements; Z1, Z2, Z3, Z4, and Z5 independently are nitrogen or carbon; R1 and R3 are alkyl; R2 is alkyl, aryl, heteroaryl, arylalkyl, or heteroarylalkyl; and R4 is alkyl or hydroxyalkyl.... University Of Pittsburgh Of The Commonwealth System Of Higher Education

Active stability devices and systems for mobile devices

A system for use with a mobile device includes at least one sensor to sense a variable related to tilting of the mobile device and at least one activatable system in operative connection with the sensor. The at least one activatable system increases stability of the mobile device upon actuation/change... University Of Pittsburgh Of The Commonwealth System Of Higher Education

Method to perform convolutions between arbitrary vectors using clusters of weakly coupled oscillators

A method to perform convolutions between arbitrary vectors includes estimating a first degree of match for a difference between a first vector having a plurality of first elements and a second vector having a plurality of second elements using a first cluster of coupled oscillators, estimating a second degree of... University Of Pittsburgh Of The Commonwealth System Of Higher Education

Formulations and carrier systems including farnesylthiosalicylic moieties

A formulation includes a carrier agent formed by conjugating at least one biologically active hydrophobic compound with at least one hydrophilic compound, the at least one biologically active hydrophobic compound selected from the group of farnesylthiosalicylic acid and a derivative of farnesylthiosalicylic acid which is biologically active as an RAS... University Of Pittsburgh Of The Commonwealth System Of Higher Education

Optical coherence tomography as a rapid, accurate, non-contact visualizing the palisades of vogt

The innovation provides for a system and method available to image and visualize the palisades of Vogt via a non-contact process, analyze the image volumes acquired, evaluate the status of the palisades of Vogt from the data represented therein, and display the data in real-time or as a part of... University Of Pittsburgh Of The Commonwealth System Of Higher Education

Electrocardiogram reconstruction from implanted device electrograms

... University Of Pittsburgh Of The Commonwealth System Of Higher Education

Biomimetic drug delivery of an immunomodulatory agent for the treatment of ocular conditions

A method for treating an ocular disorder in a subject comprising administering a therapeutic agent-loaded carrier to an ocular site of the subject in need thereof, wherein the therapeutic agent loaded-carrier provides controlled delivery of the therapeutic agent under conditions suitable for recruiting regulatory T cells to an ocular region... University Of Pittsburgh Of The Commonwealth System Of Higher Education

Vinyl substituted fatty acids

Activated fatty acids, pharmaceutical compositions including activated fatty acids, methods for using activated fatty acids to treat a variety of diseases, and methods for preparing activated fatty acids are provided herein.... University Of Pittsburgh Of The Commonwealth System Of Higher Education

Microsphere-based delivery and ex vivo manipulation of dendritic cells for autoimmune therapies

The present invention relates to tolerogenic mammalian dendritic cells (iDCs) and methods for the production of tolerogenic DCs. In addition, the present invention provides methods for administration of tolerogenic dendritic cells as well as particles containing oligonucleotides to mammalian subjects. Enhanced tolerogenicity in a host can be useful for treating... University Of Pittsburgh Of The Commonwealth System Of Higher Education

Devices, treating urological and gastrointestinal disorders by electrical stimulation of the foot

Provided herein are devices, systems, and methods for treating urological and gastrointestinal disorders, including bedwetting, through stimulation of the dorsal or plantar surface of the foot, including the superficial peroneal nerve and branches thereof, such as the dorsal intermediate and medial cutaneous nerves, or the medial and/or and lateral plantar... University Of Pittsburgh Of The Commonwealth System Of Higher Education

Implantable medical devices having double walled microspheres

An implantable medical device including at least one double-walled microsphere containing an active agent, and a biodegradable polymer layer containing the at least one double-walled microsphere.... University Of Pittsburgh Of The Commonwealth System Of Higher Education

Degradable carbon nanotube-containing biosensors and methods for target clinical marker detection

The invention relates to carbon nanotube-containing composites as biosensors to detect the presence of target clinical markers, methods of their preparation and uses in the medical field. The invention is particularly suitable for the detection in patient biological specimens of bone markers and tissue markers. The biosensors of the invention... University Of Pittsburgh Of The Commonwealth System Of Higher Education

Multiparametric assessing immune system status

The invention provides a multiparametric method of assessing the reaction of a patient's immune system to a test subject. The invention compares a patient sample reacted with a test sample and a third party sample and combines the assessments of the multiple parameters to correlate the test reaction with a... University Of Pittsburgh Of The Commonwealth System Of Higher Education

Bioerodible wraps and uses therefor

A tubular tissue graft device is provided comprising a tubular member and a restrictive fiber matrix of a bioerodible polymer about a circumference of the tubular tissue. The matrix may be electrospun onto the tubular tissue. In one embodiment, the tubular tissue is from a vein, such as a saphenous... University Of Pittsburgh Of The Commonwealth System Of Higher Education

Use of relaxin to treat atrial fibrillation

Disclosed herein are methods of using relaxin polypeptides and analogs, or nucleic acid molecules encoding such polypeptides to treat or inhibit atrial fibrillation.... University Of Pittsburgh Of The Commonwealth System Of Higher Education

11/30/17 / #20170342498

Parp genomic variants conferring resistance and sensitization to chemotherapy under inhibition

A method is provided for selecting a subject diagnosed with cancer as a candidate for treatment with a PARP1 inhibitor, or both a PARP1 inhibitor and a chemotherapeutic agent such as an alkylating agent. The method includes detecting the presence or absence of a mutation in a non-coding region of... University Of Pittsburgh Of The Commonwealth System Of Higher Education

11/30/17 / #20170343536

Multiparametric assessing immune system status

The invention provides a multiparametric method of assessing the reaction of a patient's immune system to a test subject. The invention compares a patient sample reacted with a test sample and a third party sample and combines the assessments of the multiple parameters to correlate the test reaction with a... University Of Pittsburgh Of The Commonwealth System Of Higher Education

11/30/17 / #20170343543

Degradable carbon nanotube-containing biosensors and methods for target clinical marker detection

The invention relates to carbon nanotube-containing composites as biosensors to detect the presence of target clinical markers, methods of their preparation and uses in the medical field. The invention is particularly suitable for the detection in patient biological specimens of bone markers and tissue markers. The biosensors of the invention... University Of Pittsburgh Of The Commonwealth System Of Higher Education

11/23/17 / #20170333488

Stem cell-based technologies for avian skeletal tissue engineering and regeneration

Methods are disclosed for forming bone and/or cartilage in an avian subject. The methods include administering to the avian subject a therapeutically effective amount of a composition comprising avian mesenchymal stem cells and a hydrogel that supports the differentiation of the avian mesenchymal stem cells into cells of an osteogenic... University Of Pittsburgh Of The Commonwealth System Of Higher Education

11/23/17 / #20170335382

Isothermal amplification assay for the detection of short nucleic acid sequences

Provided herein is a method of detecting short nucleic acids, such as microRNAs, in a sample, such as urine, and a kit for use in detection of the short nucleic acids.... University Of Pittsburgh Of The Commonwealth System Of Higher Education

11/23/17 / #20170337848

Myringotomy surgical training device with real-time and stored feedback on performance

A system for performing a myringotomy training procedure placing a tympanostomy tube in a simulated ear drum of a patient includes a canal structure. The canal structure includes a tubular portion having an inner surface formed from a conductive material disposed about a longitudinal axis, the tubular portion having a... University Of Pittsburgh Of The Commonwealth System Of Higher Education

11/16/17 / #20170326381

Wireless micro/nano- stimulation opto-electrode for excitable tissue

Disclosed are wireless stimulation electrode for excitable tissue. In one example, a wireless stimulation electrode includes a body made of biocompatible photovoltaic and/or photothermal material; and at least one coating surrounding at least a portion of the body, wherein at least one critical dimension of the body is substantially smaller... University Of Pittsburgh Of The Commonwealth System Of Higher Education

11/16/17 / #20170326772

System and mandrel-less electrospinning

A system for electrospinning a fiber matrix on a tubular member includes at least one nozzle, a tubular member in a spaced relationship to the at least one nozzle, and a fluid source for pressurizing a lumen of the tubular member. An electrical potential is applied between the at least... University Of Pittsburgh Of The Commonwealth System Of Higher Education

11/09/17 / #20170320898

Class of hdac inhibitors expands the renal progenitor cells population and improves the rate of recovery from acute kidney injury

Compounds and compositions are provided that inhibit histone deacylase activity and which expand renal progenitor cell populations and improve kidney function in a damaged kidney. Methods of use of the compounds and compositions are provided.... University Of Pittsburgh Of The Commonwealth System Of Higher Education

11/09/17 / #20170321113

Proppants for hydrocarbon recovery

A method of sequestering at least one target species, including exposing a proppant for use in subterranean hydrocarbon recovery via hydraulic fracturing which comprises a material adapted to sequester the at least one target species formed external to the subterranean formation and formed external to the proppant and the material,... University Of Pittsburgh Of The Commonwealth System Of Higher Education

11/09/17 / #20170322201

Antigen presenting cell assay

Disclosed herein are methods for diagnosing or predicting acute cellular and/or humoral rejection in a subject. In one example, a method of assessing organ rejection includes contacting a first sample comprising antigen presenting cells (APCs) obtained from a subject in need of or having received an organ transplant with a... University Of Pittsburgh Of The Commonwealth System Of Higher Education

10/26/17 / #20170304499

Injectable peripheral nerve specific hydrogel

The present invention relates to a peripheral nerve-specific hydrogel material, which is deliverable in a minimally invasive fashion, sustains the growth of neurons, and speeds recovery following surgical reconstruction.... University Of Pittsburgh Of The Commonwealth System Of Higher Education

10/19/17 / #20170298517

Synthesis of structured carbon material from organic materials

A method of forming a carbonized composition includes providing an organic composition, forming a protective layer over the organic composition, increasing temperature to carbonize the organic composition and for a period of time to form the carbonized composition, and removing the protective layer from the carbonized composition.... University Of Pittsburgh Of The Commonwealth System Of Higher Education

10/12/17 / #20170290773

Sphingomyelin liposomes for the treatment of hyperactive bladder disorders

The present invention provides pharmaceutical compositions and methods for the instillation of lipid vehicles comprised of liposomes containing sphingomyelin or sphingomyelin metabolites to prevent, manage, ameliorate and/or treat disorders involving neuropathic pain and aberrant muscle contractions, such as what occurs in bladder hyperactivity disorders such as interstitial cystitis (IC) in... University Of Pittsburgh Of The Commonwealth System Of Higher Education

10/12/17 / #20170290815

Glutaminase inhibitors

provided that if c is 1 and d is 0, then R2 is amino and R1 is optionally substituted alkyl, optionally substituted aralkyl, optionally substituted cycloalkyl, optionally substituted heteroaralkyl, optionally substituted alkylalkoxy, optionally substituted alkylaryloxy, optionally substituted aryl, optionally substituted heteroaryl, or optionally substituted heterocycloalkyl.... University Of Pittsburgh Of The Commonwealth System Of Higher Education

10/12/17 / #20170290917

Engineered microparticles for macromolecule delivery

making a modified release composition based on the optimal ratio determination.... University Of Pittsburgh Of The Commonwealth System Of Higher Education

10/05/17 / #20170283782

Trpv1 modulatory gene product that affects trpv1-specific pain behavioral responses identified in a functional screen of an hsv-based cdna library

The invention provides a method for ameliorating chronic pain signaling involving transient receptor potential cation channel subfamily V member 1 (TRPV1) by expressing PP1α in neurons. The invention also provides HSV vectors for expressing PP1α within neurons and compositions comprising such vectors.... University Of Pittsburgh Of The Commonwealth System Of Higher Education

09/28/17 / #20170274025

Oncolytic hsv vector

The present invention provides a recombinant herpes simplex virus (HSV), comprising (a) a mutation of the glycoprotein B (gB) at position 285 or 549, (b) a plurality of copies of one or more microRNA target sequences inserted into a locus of an HSV gene required for HSV replication, wherein said... University Of Pittsburgh Of The Commonwealth System Of Higher Education

09/21/17 / #20170266352

Layer by layer coated mesh for local release of bio-active proteins

The present invention relates to biomaterials coated with an active agent eluting coating, wherein implantation of the coated biomaterial results in reduced implant-related complications and/or improved integration of the biomaterial into the host tissue and further relates to kits containing the coated biomaterial. The present invention also relates to methods... University Of Pittsburgh Of The Commonwealth System Of Higher Education

09/21/17 / #20170267556

Managing naturally occurring radioactive material in wastewater

A method of treating wastewater including calcium ions and radium ions includes charging the wastewater into a container via an inlet in the container, precipitating a portion of the calcium ions in the wastewater within the container as calcium carbonate, removing an outflow via an outlet in the container, and... University Of Pittsburgh Of The Commonwealth System Of Higher Education

09/07/17 / #20170252485

Ovarian-derived hydrogels for biomedical and biotechnology applications

The present invention relates to an ovarian-derived hydrogel material, which can be useful for three-dimensional in vitro culturing of cells, cell therapy, fertility preservation, drug delivery, site-specific remodeling and repair of damaged tissue, and/or diagnostic kits.... University Of Pittsburgh Of The Commonwealth System Of Higher Education

09/07/17 / #20170253854

Use of adipose-derived stem cells for glaucoma treatment

A method of preparing a functional trabecular meshwork (TM) cell from adipose-derived stem cells is provided. Methods of treating glaucoma, implanting trabecular meshwork (TM) cells, or repairing or regenerating the aqueous outflow pathway of an eye of a patient also are provided.... University Of Pittsburgh Of The Commonwealth System Of Higher Education

09/07/17 / #20170254800

Multiparametric assessing immune system status

The invention provides a multiparametric method of assessing the reaction of a patient's immune system to a test subject. The invention compares a patient sample reacted with a test sample and a third party sample and combines the assessments of the multiple parameters to correlate the test reaction with a... University Of Pittsburgh Of The Commonwealth System Of Higher Education

08/31/17 / #20170245936

Sensor guided catheter navigation system

A method and a system for producing images of a subject, such as the heart of a human being. The method may comprise acquiring ultrasound images of the subject with a catheter comprising a position sensor. The method may also comprise capturing a plurality of 4D surface registration points in... University Of Pittsburgh Of The Commonwealth System Of Higher Education

08/31/17 / #20170246164

Small molecules targeting androgen receptor nuclear localization and/or level in prostate cancer

R23 is an aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocycloalkyl, substituted heterocycloalkyl, alkoxy, aryloxy, a silyl-containing group, a boryl-containing group, a phosphine-containing group, amino, a thio-containing group, a seleno-containing group, halide, or a nitro-containing group.... University Of Pittsburgh Of The Commonwealth System Of Higher Education

08/31/17 / #20170246350

"bioengineered human corneal stromal tissue"

Provided herein is a method of making an aligned ECM scaffold useful in refractive correction of the eye and repair of the cornea. Methods of use of the scaffold as well as a scaffold construct are provided.... University Of Pittsburgh Of The Commonwealth System Of Higher Education

08/31/17 / #20170247382

Small molecules targeting androgen receptor nuclear localization and/or level in prostate cancer

R23 is an aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocycloalkyl, substituted heterocycloalkyl, alkoxy, aryloxy, a silyl-containing group, a boryl-containing group, a phosphine-containing group, amino, a thio-containing group, a seleno-containing group, halide, or a nitro-containing group.... University Of Pittsburgh Of The Commonwealth System Of Higher Education

08/24/17 / #20170240594

Therapeutic use of peptide inhibitors of nadph oxidase; aerosolization as a delivery mechanism

A method is provided for treatment of a condition mediated by Nox2 in a patient. The method comprises administering to the patient by inhalation a polypeptide as described herein, able to inhibit superoxide production by Nox2. Conditions treatable in this manner include, without limitation, one or more of: right ventricular... University Of Pittsburgh Of The Commonwealth System Of Higher Education

08/24/17 / #20170240924

Methods for treating cells containing fusion genes

The present invention relates to methods for treating prostate cancer patients. It is based, at least in part, on the discovery that approximately 90% of men carrying at least one of the following fusion genes: TRMT11-GRIK2, SLC45A2-AMACR, MTOR-TP53BP1, LRRC59-FLJ60017, TMEM135-CCDC67 and CCNH-C5orf30 experienced prostate cancer recurrence, metastases and/or prostate cancer-specific... University Of Pittsburgh Of The Commonwealth System Of Higher Education

08/17/17 / #20170233879

Non-noble metal based electro-catalyst compositions for proton exchange membrane based water electrolysis and methods of making

The invention provides electro-catalyst compositions for an anode electrode of an acid mediated proton exchange membrane-based water electrolysis system. The compositions include a noble metal component selected from the group consisting of iridium oxide, ruthenium oxide, rhenium oxide and mixtures thereof, and a non-noble metal component selected from the group... University Of Pittsburgh Of The Commonwealth System Of Higher Education

Patent Packs
08/10/17 / #20170226074

Antifibrotic effects of oxetanyl sulfoxides

R25 is H, alkyl, substituted alkyl, halogen, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, C1-C3 alkoxy, aryloxy, or —(CH2)qOR17, wherein R17 is alkyl an aryl and q is an integer in the range of 1 to 10.... University Of Pittsburgh Of The Commonwealth System Of Higher Education

08/10/17 / #20170224686

Targeting cyb5r3

Ar is optionally substituted aryl or optionally substituted heteroaryl.... University Of Pittsburgh Of The Commonwealth System Of Higher Education

08/10/17 / #20170226074

Antifibrotic effects of oxetanyl sulfoxides

R25 is H, alkyl, substituted alkyl, halogen, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, C1-C3 alkoxy, aryloxy, or —(CH2)qOR17, wherein R17 is alkyl an aryl and q is an integer in the range of 1 to 10.... University Of Pittsburgh Of The Commonwealth System Of Higher Education

08/03/17 / #20170219585

Activation of myeloid-derived suppressor cells as a predictor of patient response to interferon-a therapy

The present invention relates to methods and materials for more effectively treating patients with interferon. It is based on the discovery that clinical response to interferon (IFN) therapy is mediated in part by inhibition of activation of MDSC and such inhibition can be observed after a test dose of interferon;... University Of Pittsburgh Of The Commonwealth System Of Higher Education

07/27/17 / #20170209242

Dental abutment screw extractor

Described herein are systems and methods for extracting a broken fragment of a dental abutment screw from a dental implant. An exemplary system comprises an extractor tool having a tubular outer body and a conductor positioned within the tubular outer body, and an applicator that receives and end of the... University Of Pittsburgh Of The Commonwealth System Of Higher Education

07/27/17 / #20170209495

Skeletal muscle augmentation utilizing muscle-derived progenitor compositions, and treatments thereof

The present invention provides muscle-derived progenitor cells (MDCs) that show long-term survival following transplantation into body tissues and which can augment soft tissue following introduction into a site of soft tissue. Also provided are methods of isolating MDCs. The invention further provides methods of using compositions comprising MDCs for the... University Of Pittsburgh Of The Commonwealth System Of Higher Education

07/27/17 / #20170211069

Use of the chromosome 19 microrna cluster (c19mc) for treating microbial disease and promoting authophagy

It is disclosed herein that cultured primary placental human trophoblast (PHT) cells are highly resistant to infection by a number of disparate viruses, and confer this resistance to non-placental recipient cells by exosome-mediated delivery of microRNAs (miRs). PHT cells express high levels of unique, primate-specific miRNAs, expressed from the chromosome... University Of Pittsburgh Of The Commonwealth System Of Higher Education

07/20/17 / #20170202947

Computationally optimized broadly reactive antigens for influenza

The development of a computationally optimized influenza HA protein that elicits broadly reactive immune response to all H5N1 influenza virus isolates is described. The optimized HA protein was developed through a series of HA protein alignments, and subsequent generation of consensus sequences, for clade 2 H5N1 influenza virus isolates. The... University Of Pittsburgh Of The Commonwealth System Of Higher Education

07/13/17 / #20170196685

Artificial valved conduits for cardiac reconstructive procedures and methods for their production

Artificial heart valve structures and methods of their fabrication are disclosed. The heart valve structures may be fabricated from a biocompatible polymer and include one or more heart valve leaflet structures incorporated within a conduit. The valve structures may incorporate one or more conduit sinuses, as well as a gap... University Of Pittsburgh Of The Commonwealth System Of Higher Education

07/13/17 / #20170199204

Urine biomarkers for prediction of recovery after acute kidney injury: proteomics

This invention is related to the field of the prevention and treatment of kidney disease. The treatment of kidney disease may be tailored depending upon the need for, or expectation of, renal recovery. For example, renal recovery can be determined by monitoring urine biomarkers related to the development of chronic... University Of Pittsburgh Of The Commonwealth System Of Higher Education

07/06/17 / #20170189495

Use of microperoxidases for the treatment of carboxyhemoglobinemia

It is disclosed herein that microperoxidases are capable of binding carbon monoxide (CO) with high affinity and displacing CO from hemoglobin, thereby acting as CO scavengers. The present disclosure provides methods of treating carboxyhemoglobinemia (or CO poisoning) in a subject by administering a therapeutically amount of an isolated or recombinant... University Of Pittsburgh Of The Commonwealth System Of Higher Education

07/06/17 / #20170189514

Identification of mutations in herpes simplex virus envelope glycoproteins that enable or enhance vector retargeting to novel non-hsv receptors

In one embodiment, the invention provides an HSV vector comprising a mutant gB and/or a mutant gH glycoprotein, where the viral envelope further comprises a non-native ligand specific for a protein present on the surface of a predetermined cell type. In another embodiment, the invention provides an HSV vector comprising... University Of Pittsburgh Of The Commonwealth System Of Higher Education

07/06/17 / #20170189684

Monitoring and regulating physiological states and functions via sensory neural inputs to the spinal cord

Methods and apparatuses for monitoring and regulating physiological states and functions are disclosed. Several embodiments include application of one or more microelectrode arrays to a dorsal root ganglion for measurement of sensory neuron activity, or stimulation of sensory reflex circuits. The methods and apparatuses can be used, for example, for... University Of Pittsburgh Of The Commonwealth System Of Higher Education

07/06/17 / #20170190758

Engineered receptors and their use

Engineered chloride channel receptors, nucleic acids encoding these receptors, expression vectors including these nucleic acids are disclosed herein. Nanoparticles and pharmaceutical compositions including these engineered chloride channel receptors, nucleic acids, and expression vectors are disclosed. The use of these compositions and nanoparticles, such as for the treatment of pain, cystic... University Of Pittsburgh Of The Commonwealth System Of Higher Education

06/29/17 / #20170184696

Universal, modular temperature controlled mri phantom for calibrated anisotropic and isotropic imaging including hollow fluid filled tubular textiles for calibrated anisotropic imaging

A universal, modular, temperature controlled MRI phantom for calibration and validation for anisotropic and isotropic imaging comprises an outer insulating shell configured to be received within an MRI chamber; an inner shell received within the outer insulating shell; a fluid conduits adjacent the inner shell for receiving temperature controlling fluid... University Of Pittsburgh Of The Commonwealth System Of Higher Education

Patent Packs
06/29/17 / #20170182128

Method of treating heart failure

The present invention includes methods, systems, uses, and means for the delivery of one or more anti-fibrotic agents into the pericardial space for the treatment and prevention of heart failure (HF).... University Of Pittsburgh Of The Commonwealth System Of Higher Education

06/29/17 / #20170182319

"methods and systems for achieving a physiological response by pudendal nerve stimulation and blockade"

Methods and apparatus are therefore provided herein for stimulating a desired physiological effect. The methods and apparatus can be used to control micturition, defecation and/or ejaculation. The methods and apparatus also can be used to control pain in the lower pelvic region, for example and without limitation, interstitial cystitis. The... University Of Pittsburgh Of The Commonwealth System Of Higher Education

06/29/17 / #20170183732

Transcriptional signature for chlamydial pelvic inflammatory disease

Methods are provided herein for determining the likelihood that a subject, such as an asymptomatic subject, has chlamydial pelvic inflammatory disease. In some embodiments, the method can determine the likelihood that a pharmaceutical agent is effective for treating a subject that has chlamydial pelvic inflammatory disease. In other specific non-limiting... University Of Pittsburgh Of The Commonwealth System Of Higher Education

06/22/17 / #20170173126

Identification of pneumocystis antigens and uses thereof

Pneumonia due to the fungus Pneumocystis jirovecii is a life-threatening infection that occurs in immunocompromised patients. The inability to culture the organism as well as the lack of a sequenced genome has hindered antigen discovery that could be useful in developing effective vaccines, therapeutic antibodies and diagnostic methods. A method... University Of Pittsburgh Of The Commonwealth System Of Higher Education

06/22/17 / #20170173127

Kexin-derived vaccines to prevent or treat fungal infections

A vaccine is disclosed that promotes CD4+ T cell-independent host defense mechanisms to defend against infection by fungi such as Pneumocystis spp. The vaccine may be used to prevent or to treat fimgal infections. The novel vaccine can provide protective immunity, even for immunocompromised individuals such as HIV patients having... University Of Pittsburgh Of The Commonwealth System Of Higher Education

06/22/17 / #20170173254

Devices, cell modification

A method of modifying cells includes removing fluid including cells from a patient, contacting the removed fluid from the patient with at least one surface upon which at least one agent to interact at least one cell receptor is immobilized to modify cells in the fluid, and returning the fluid... University Of Pittsburgh Of The Commonwealth System Of Higher Education

06/22/17 / #20170174740

Kv2.1 channel-derived peptides and methods of use

Peptides capable of interfering with the Kv2.1-mediated apoptotic K+ current surge that leads to neuronal cell death are described. The disclosed peptides are derived from the C-terminal region of Kv2.1, which mediates binding to the SNARE protein syntaxin. Disruption of Kv2.1 binding to syntaxin inhibits the apoptotic K+ current surge... University Of Pittsburgh Of The Commonwealth System Of Higher Education

06/15/17 / #20170165048

Device for changing course of vessel and treatment method using the same

The present invention relates to a device for changing a course of a vessel, a method of introducing the device, a method of changing a course of a vessel using the device, and a treatment method of brain-nervous system diseases, such as neurovascular compression syndrome, using the device. In treating... University Of Pittsburgh Of The Commonwealth System Of Higher Education

06/08/17 / #20170156569

Steerable, follow the leader device

A highly articulated robotic probe (HARP) is comprised of a first mechanism and a second mechanism, one or both of which can be steered in desired directions. Each mechanism can alternate between being rigid and limp. In limp mode the mechanism is highly flexible. When one mechanism is limp, the... University Of Pittsburgh Of The Commonwealth System Of Higher Education

06/08/17 / #20170156699

Contrast assisted intravascular ultrasound imaging

A method of imaging a blood vessel includes delivering a bubble-based contrast agent within the vessel and positioning at least one ultrasound device in the vicinity of the bubble-based contrast agent within the vessel. A first burst of low-frequency ultrasound energy can be delivered to excite the bubble-based contrast agent... University Of Pittsburgh Of The Commonwealth System Of Higher Education

06/08/17 / #20170156815

Apparatus and implantation of devices into soft tissue

Apparatus and method for surgeon-assisted rapid surgical implantation of devices into soft tissue. The apparatus comprises several subsystems that enable the referencing of the spatial position and orientation of the device being implanted with respect to the soft tissue into which it is being implanted and then the controlled implantation... University Of Pittsburgh Of The Commonwealth System Of Higher Education

06/08/17 / #20170157217

Use of endostatin peptides for the treatment of fibrosis

C-terminal endostatin polypeptides are disclosed herein. Polynucleotides encoding these polypeptide, host cells transformed with the polynucleotides, and methods of using these polypeptides and polynucleotides are disclosed. Uses of these polypeptide, polynucleotides and expression vectors include the treatment of fibrosis in a subject. Thus, methods are provided for treating fibrosis, including... University Of Pittsburgh Of The Commonwealth System Of Higher Education

06/01/17 / #20170151317

Peptide analogs capable of enhancing stimulation of a glioma-specific ctl response

The invention provides a peptide derived from the interleukin-13 receptor α2, which serves as a HLA-A2-restricted cytotoxic T lymphocyte (CTL) epitope. The invention can be used as a vaccine for glioma and can be formulated into compositions for medical or veterinary use. In addition, the invention provides the use of... University Of Pittsburgh Of The Commonwealth System Of Higher Education

06/01/17 / #20170152565

Method for diagnosing renal diseases or predispositions

The invention provides a method of diagnosing a disease or a predisposition to contract a disease by assaying for mutations of uromodulin (UMOD) within a test subject or patient. The presence of a mutation in the UMOD supports a diagnosis of a disease or a predisposition to contract a disease... University Of Pittsburgh Of The Commonwealth System Of Higher Education

05/18/17 / #20170135639

Skin screw electrodes

Electrodes providing excellent recording and physical stability. Electrodes are disclosed that may include a plurality of small teeth that possess a novel design shape and orientation. The shallow and relatively long teeth run parallel to the rim of the electrode that presses against the patient's skin. When the electrode is... University Of Pittsburgh Of The Commonwealth System Of Higher Education

05/04/17 / #20170121374

Computationally optimized broadly reactive antigens for h1n1 influenza

Described herein is the generation of optimized H1N1 influenza HA polypeptides for eliciting a broadly reactive immune response to H1N1 influenza virus isolates. The optimized HA polypeptides were developed through a series of HA protein alignments, and subsequent generation of consensus sequences, based on selected H1N1 viruses isolated from 1918-2011.... University Of Pittsburgh Of The Commonwealth System Of Higher Education

04/27/17 / #20170112946

Methods and materials for increasing viral vector infectivity

This document relates to methods and materials for increasing viral vector infectivity. For example, methods and materials for using spliceosome inhibitors (e.g., U2 snRNP spliceosome inhibitors such as meayamycin B or pladienolide derivative E7107) to increase viral vector (e.g., adeno-associated virus-based vector) infectivity are provided.... University Of Pittsburgh Of The Commonwealth System Of Higher Education

04/27/17 / #20170112964

Method and composition for treating inflammatory bowel disease without colectomy

Methods and compositions for treating diseased or damaged tissue, such as Inflammatory Bowel Disease, e.g., Ulcerative Colitis, include tissue regeneration using stem cells or tissue grafts which stimulate stem cell migration to the damaged tissue. The tissue grafts can be extracellular matrix (ECM) material, such as tissue-specific extracellular matrix (TS-ECM).... University Of Pittsburgh Of The Commonwealth System Of Higher Education

04/27/17 / #20170114102

Computationally optimized broadly reactive antigens for h1n1 influenza

Described herein is the generation of optimized H1N1 influenza HA polypeptides for eliciting a broadly reactive immune response to H1N1 influenza virus isolates. The optimized HA polypeptides were developed through a series of HA protein alignments, and subsequent generation of consensus sequences, based on selected H1N1 viruses isolated from 1918-2012.... University Of Pittsburgh Of The Commonwealth System Of Higher Education

04/20/17 / #20170107190

Antifibrotic effects of oxetanyl sulfoxides

R25 is H, alkyl, substituted alkyl, halogen, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, C1-C3 alkoxy, aryloxy, or —(CH2)qOR17, wherein R17 is alkyl an aryl and q is an integer in the range of 1 to 10.... University Of Pittsburgh Of The Commonwealth System Of Higher Education

04/20/17 / #20170107262

Computationally optimized broadly reactive antigens for human and avian h5n1 influenza

Described herein is the generation of optimized H5N1 influenza HA polypeptides for eliciting a broadly reactive immune response to H5N1 influenza virus isolates. The optimized HA polypeptides were developed through a series of HA protein alignments, and subsequent generation of consensus sequences, based on human and avian H5N1 isolates. Provided... University Of Pittsburgh Of The Commonwealth System Of Higher Education

04/20/17 / #20170107537

Identification of mutations in herpes simplex virus envelope glycoproteins that enable or enhance vector retargeting to novel non-hsv receptors

The present invention provides an HSV vector comprising an envelope comprising one or more mutant gB and/or gH envelope glycoproteins, whereby the HSV vector exhibits at least 25% increased rate-of-entry after 20 minutes when assayed at 30° C. or 37° C. in Vero cells after first incubating at 4° C.... University Of Pittsburgh Of The Commonwealth System Of Higher Education








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