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University Of Rochester patents


Recent patent applications related to University Of Rochester. University Of Rochester is listed as an Agent/Assignee. Note: University Of Rochester may have other listings under different names/spellings. We're not affiliated with University Of Rochester, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "U" | University Of Rochester-related inventors


Anti-glucosaminidase passive immunization for staphylococcus aureus infections

The present invention is directed to a monoclonal antibody that binds specifically to a Staphylococcus aureus glucosaminidase and inhibits in vivo growth of S. aureus. Also disclosed are monoclonal antibody binding portions, recombinant or hybridoma cell lines, pharmaceutical compositions containing the monoclonal antibody or binding portions thereof, and methods of... University Of Rochester

Anti-glucosaminidase passive immunization for staphylococcus aureus infections

The present invention is directed to a monoclonal antibody that binds specifically to a Staphylococcus aureus glucosaminidase and inhibits in vivo growth of S. aureus. Also disclosed are monoclonal antibody binding portions, recombinant or hybridoma cell lines, pharmaceutical compositions containing the monoclonal antibody or binding portions thereof, and methods of... University Of Rochester

Apparatus and enhancing corneal lenticular surgery with laser refractive index changes

Methods and systems wherein laser induced refractive index changes by focused femtosecond laser pulses in optical tissues is performed in combination with corneal lenticular surgery to achieve overall desired vision corrections.... University Of Rochester

System and method to assess risk of changes to brain white matter based on head impact dose equivalent number

A system to assess risk of changes to brain white matter includes a sensor system adapted to measure an energy of each impact to an individual belonging to a sub-population that causes a repetitive head impact (RHI). A head impact dose equivalent number (HIDEN) process calculates a HIDEN for a... University Of Rochester

Methods for identifying, diagnosing, and predicting survival of lymphomas

Gene expression data provides a basis for more accurate identification and diagnosis of lymphoproliferative disorders. In addition, gene expression data can be used to develop more accurate predictors of survival. The present invention discloses methods for identifying, diagnosing, and predicting survival in a lymphoma or lymphoproliferative disorder on the basis... University Of Rochester

Ultrasound system for high-speed and high resolution imaging applications

An ultrasound imaging system includes an array of ultrasound transducer elements chat send ultrasound energy into an object when energized for respective transmission time periods and provide responses to ultrasound energy emitted from the object for respective reception time periods, a reception modulation circuit modulating the responses with irregular sequences... University Of Rochester

Per-channel color barcodes for displays

A method of decoding a coherent RGB color barcode captured by a RGB camera includes: displaying a coherent RGB color barcode on the RGB display; capturing an image of the displayed barcode; performing a pilot block RGB color interference cancellation process to estimate a per pixel color interference; applying the... University Of Rochester

Novel approach to treatment of hyperglycemia using a nanoparticle encapsulated peptide

The present invention relates to compositions and methods for treating or preventing hyperglycemia and diseases associated with hyperglycemia. In certain embodiments, the composition comprises a peptide having the amino acid sequence KRSCYK wherein the peptide consists of D-amino acids is useful in treating or preventing diabetes. In some aspects, the... University Of Rochester

Methods of diagnosing bacterial infections

The present invention relates to compositions and methods useful for the assessment, diagnosis, and treatment of bacterial infections.... University Of Rochester

Resistive memory accelerator

Presented is a method and apparatus for solving. The method includes receiving, by a resistive memory array, a first data, the resistive memory array comprising a plurality of cells, wherein the receiving comprises setting a plurality of resistances on the plurality of cells, wherein each of the plurality of resistances... University Of Rochester

Use of inhibitors of binding between a par-1 receptor and its ligands for the treatment of glioma

The present invention relates to a method of treating glioma in a subject. The method comprises selecting a subject having a glioma, providing an inhibitor of binding between a PAR-1 receptor and a ligand of the PAR-1 receptor, and administering the inhibitor to the selected subject under conditions effective to... University Of Rochester

Compositions and methods to inhibit estrogen receptor beta for the treatment of renal cell carcinoma

The invention provides compositions and methods for treating and preventing cancer. The invention relates to compositions and methods for treating subjects having a cancer associated with overexpression of estrogen receptors, especially in males. The invention comprises inhibitors of ERβ, inhibitors of TGFβ-1, inhibitors of SMAD, or inhibitors of HIF, or... University Of Rochester

Ultrasound technology to control the spatial organization of cells and proteins in engineered tissues

The present invention is directed to methods of inducing spatial organization of cells an in vitro culture system using ultrasound technology. The invention is further directed to methods of inducing extracellular matrix remodeling and neovessel formation in an in vitro culture system and generating vascularized engineered tissue constructs using ultrasound... University Of Rochester

Efficient lasing with excited-state absorption-impaired materials

Laser signal intensity is resonantly enhanced within a laser cavity to be greater than a pump intensity. This enables the suppression of excited-state absorption and is applicable to terbium-doped fiber lasers, lambda-type materials, or other materials used in lasers. In other embodiments, ESA is suppressed by de-populating the higher excited... University Of Rochester

Synergistic compositions for treating microbial infections

Synergistic pharmaceutical compositions including an RNase P inhibitor and a tRNA synthetase inhibitor are provided, as well as methods for their use in treating infections. Also provided herein are methods of using the compositions to inhibit a bacterial tRNA synthetase in a cell and to decolonize bacteria on a surface.... University Of Rochester

Compositions and methods for enhancing cardiac function in the neonate

The invention provides novel pharmaceutical compositions and methods for treating newborns in need of enhanced cardiac function, in particular, newborns suffering from cardiomyopathy, or a related disease or condition.... University Of Rochester

Context-dependent piano music transcription with convolutional sparse coding

The present disclosure presents a novel approach to automatic transcription of piano music in a context-dependent setting. Embodiments described herein may employ an efficient algorithm for convolutional sparse coding to approximate a music waveform as a summation of piano note waveforms convolved with associated temporal activations. The piano note waveforms... University Of Rochester

Registration of aerial imagery to vector road maps with on-road vehicular detection and tracking

Methods for aligning images captured by aerial imaging platforms with a road network described by geo-referenced data, including the steps of: (a) identifying locations of moving vehicles in at least one image; (b) estimating a coordinate transformation that aligns the identified locations with the road network described by the geo-referenced... University Of Rochester

Artemisinin derivatives, methods for their preparation and their use as antimalarial agents

Derivatives of the antimalarial agent artemisinin, compositions comprising the derivatives, methods for preparing the derivatives, and their uses in pharmaceutical compositions intended for the treatment of parasitic infections are provided. Methods are provided for the production of artemisinin derivatives via functionalization of positions C7 and C6a, and optionally, in conjunction... University Of Rochester

Small molecule anti-scarring agents

Disclosed are methods of treating fibrosis in a patient in need thereof that includes administering to the patient an amount of an active agent, as identified herein, that is therapeutically effective to inhibit myofibroblast formation and thereby treat the fibrosis. Also disclosed is a recombinant cell line that includes a... University Of Rochester

Treating myelin diseases with optimized cell preparations

The disclosure relates to oligodendrocyte-biased glial progenitor cells and methods of making, isolating, and using such cells.... University Of Rochester

Enhanced algorithm for the detection of eye motion from fundus images

A method, controller, and non-transitory medium for obtaining images of a moving subject. Estimating changes in position of the subject based on the images. Calculating a quality metric of the estimation of the change. Comparing the quality metric to a threshold. In a first case in which the quality metric... University Of Rochester

Novel arenavirus vaccine

The invention relates to compositions and methods for preventing or treating arenavirus related diseases and disorders through the administration to a subject in need thereof a live-attenuated virus (LAV), wherein the LAV is a codon deoptimized (CD) arenavirus.... University Of Rochester

Induced pluripotent cell-derived oligodendrocyte progenitor cells for the treatment of myelin disorders

The present invention relates to preparations of induced pluripotent cell-derived oligodendrocyte progenitor cells, and methods of making, isolating, and using these preparations.... University Of Rochester

Measurement of the lipid and aqueous layers of a tear film

Systems and methods for determining thickness of lipid and aqueous layers of a tear film in which a spectrum array is generated from optical coherence tomography and input into a statistical estimator, which determines the thickness of the lipid and/or aqueous layers at a nanometer resolution based on the inputted... University Of Rochester

System and real-time eye tracking for a scanning laser ophthalmoscope

Systems and methods for real-time eye tracking using a SLO or other imaging device are described. The systems and methods provide robust and accurate image-based eye tracking for both small and large field SLO, with or without adaptive optics. Methods for rapidly re-locking the tracking of a subject's eye position... University Of Rochester

Real-time laser modulation and delivery in ophthalmic devices for scanning, imaging, and laser treatment of the eye

Systems and methods of real-time laser control and modulation for ophthalmic devices are described. The systems and methods can be used for precise laser delivery at sub-micron resolution in both laser treatment and scan imaging processes. In various embodiments, the systems can include a laser delivery device useful for surgical... University Of Rochester

Metabolic biomarkers for memory loss

The present invention relates to methods of determining if a subject has an increased risk of suffering from memory impairment. The methods comprise analyzing at least one plasma sample from the subject to determine a value of the subject's metabolite profile and comparing the value of the subject's metabolite profile... University Of Rochester

Optical material and modifying the refractive index

An optical device comprising an optical hydrogel with select regions that have been irradiated with laser light having a pulse energy from 0.01 nJ to 50 nJ and a wavelength from 600 nm to 900 nm. The irradiated regions are characterized by a positive change in refractive index of from... University Of Rochester

Non-human mammal model of human degenerative disorder, uses thereof, and treating human degenerative disorder

The present application relates to a non-human mammal model of a human neurodegenerative disorder, methods of producing the non-human mammal model, and methods of using the non-human mammal model to identify agents suitable for treating a neurodegenerative disorder. The present application also relates to methods of treating neurodegenerative disorders and... University Of Rochester

Non-human mammal model of human degenerative disorder, uses thereof, and treating human degenerative disorder

The present application relates to a non-human mammal model of a human neurodegenerative disorder, methods of producing the non-human mammal model, and methods of using the non-human mammal model to identify agents suitable for treating a neurodegenerative disorder. The present application also relates to methods of treating neurodegenerative disorders and... University Of Rochester

Genetic markers for memory loss

The present invention relates to methods of determining if a subject has an increased risk of suffering from memory impairment. The methods comprise analyzing the gene expression profile from peripheral blood leukocytes taken from the subject and comparing the value of the subject's gene expression profile with the value of... University Of Rochester

Exosome and lipid biomarkers for memory loss

The present invention relates to methods of determining if a subject has an increased risk of suffering from memory impairment. The methods comprise analyzing at least one sample from the subject to determine a value of the subject's exosomal profile or combined biomarker profile (lipids plus exosomal cargo) and comparing... University Of Rochester

Polarized hydroxyapatite films and methods of making and using same

Polarized hydroxyapatite films disposed on a substrate. The films have a residual polarization of at least 5 mC/cm2. Also provided are methods of making and using polarized hydroxyapatite. The films can be used as coatings of medical devices, such as, for example, medical implants.... University Of Rochester

Scattering and reflection identification system and method

A method of forming an image of a region of interest using a pulse-echo imaging device is described. The method includes the steps of transmitting a pulse, discriminating an echo of the pulse by comparison to a plurality of Hermite polynomials, and determining a color for display based on the... University Of Rochester

06/15/17 / #20170169714

Methods and systems for cognitive training using high frequency heart rate variability

Disclosed are systems and methods for administering cognitive training to a subject in need thereof.... University Of Rochester

06/08/17 / #20170156619

Ecg clock electrocardiogram based diagnostic device and method

An ECG clock electrocardiogram based diagnostic device and method is disclosed. The ECG clock provides a clear visual indicator of heart related anomalies such as Long QT syndrome over a longer span of time than can otherwise be assimilated by a medical practitioner. A variable such as QT interval is... University Of Rochester

06/08/17 / #20170156931

Multi-photon absorption for femtosecond micromachining and refractive index modification of tissues

By adapting femtosecond micromachining approaches developed in hydrogels, we can perform Intra-tissue Refractive Index Shaping (IRIS) in biological tissues. We reduced femtosecond laser pulse energies below the optical breakdown thresholds to create grating patterns that are associated with a change in the refractive index of the tissue. To increase two-photon... University Of Rochester

06/01/17 / #20170152287

Methods and compositions for site-specific labeling of peptides and proteins

Methods and compositions are provided for covalently linking a chemical species to a recombinant or synthetic polypeptide. The methods involve the reaction of a thioester-comprising polypeptide with a reagent comprising a reactive amino-thiol group connected to the chemical species which is to be covalently linked to the polypeptide, via a... University Of Rochester

05/25/17 / #20170145506

Signature of longitudinal gene expression changes to diagnose brain injury

Described herein are compositions and methods relating to biomarkers used to diagnose brain injury in a subject who has experienced a head trauma. The biomarkers described herein can be used to diagnose, monitor the onset, monitor the progression, and assess the recovery of brain injury. The biomarkers can also be... University Of Rochester

05/11/17 / #20170132785

Method and system for evaluating the quality of a surgical procedure from in-vivo video

The quality of surgeries in captured videos is modeled in a learning network. For this task, a dataset of surgical video is given with a corresponding set of scores that are labeled by reviewers, to learn a model for quality assessment of surgical procedures. A learned model is then used... University Of Rochester

04/13/17 / #20170100414

Small molecule efflux pump inhibitors

Small molecule efflux pump inhibitors are provided, as well as methods for their use in treating infections. Also provided herein are methods of using the small molecule efflux pump inhibitors to restore the antibiotic susceptibility of microbes.... University Of Rochester

04/13/17 / #20170100797

Femtosecond laser pulse surface structuring methods and materials resulting therefrom

Embodiments of the present invention are generally directed to materials processing methods using femtosecond duration laser pulses, and to the altered materials obtained by such methods. The resulting nanostructured (with or without macro- and micro-structuring) materials have a variety of applications, including, for example, aesthetic applications for jewelry or ornamentation;... University Of Rochester

04/13/17 / #20170102557

Customized wavefront-guided methods, systems, and devices to correct higher-order aberration

Methods and systems for manufacturing a wavefront-guided scleral lens prosthetic device customized for an eye of a patient include obtaining a first scleral lens prosthetic device with a central optic zone configured to vault over the eye's cornea and a peripheral haptic zone configured to align with the eye's sclera,... University Of Rochester

03/16/17 / #20170072062

Compositions and methods for controlled localized delivery of bone forming therapeutic agents

The present invention provides compositions and methods for providing controllable local delivery of a therapeutic agent to promote bone formation. In certain embodiments, the invention is used as a treatment for a subject with osteoporosis, bone cancer or bone fracture. The invention provides a therapeutic agent that is tethered to... University Of Rochester

03/16/17 / #20170072330

Responsive construction toy

A responsive construction toy is disclosed. The responsive construction toy, also known as LumenLinks™, comprises at least one active rod and at least one connector. The active rod has an optics end and a push-pull transducer. The active rod illuminates with varying intensity and color to signify magnitude and direction... University Of Rochester

03/16/17 / #20170075806

Parallel memory allocator employing liveness metrics

A liveness-based memory allocation module operating so that a program thread invoking the memory allocation module is provided with an allocation of memory including a reserve of free heap slots beyond the immediate requirements of the invoking thread. The module receives a parameter representing a thread execution window from an... University Of Rochester

03/09/17 / #20170065540

Methods and compositions for treating infection

Provided herein are compositions and methods for treating or preventing infection.... University Of Rochester

03/09/17 / #20170067871

High-throughput cellular analysis using microbubble arrays

A microfabricated device and method having a substrate with an array of curvilinear cavities that is used for high throughput single cell screening. The substrate of the device is preferably fabricated in a low elastic modulus polymer such as polydimethylsiloxane. The architecture of the cavity forms a small volume micro-niche... University Of Rochester

02/23/17 / #20170052204

Metabolic and genetic biomarkers for memory loss

The present invention relates to methods of determining if a subject has an increased risk of suffering from memory impairment. The methods comprise analyzing at least one plasma sample from the subject to determine a value of the subject's lipidomic profile, and also analyzing the gene expression profile from leukocytes... University Of Rochester

02/09/17 / #20170035613

Method for modifying the refractive index of ocular tissues

A method for providing vision correction to a patient. The method includes: (a) measuring the degree of vision correction needed by the patient and determining the location and shape of refractive structures that need to be positioned within the cornea to partially correct a patient's vision; (b) directing and focusing... University Of Rochester

02/09/17 / #20170037084

Macrocyclic peptidomimetics for alpha-helix mimicry

Methods and compositions are provided for generating macrocyclic peptides constrained by side-chain-to-C-terminus non-peptidic tethers for use as functional and structural mimics of α-helical motifs, including in therapeutic applications. These methods can be used to produce libraries of conformationally constrained peptidomimetics to identify compounds with desired activity properties.... University Of Rochester

02/09/17 / #20170040054

Resistive memory accelerator

Presented is a method and apparatus for solving. The method includes receiving, by a resistive memory array, a first data, the resistive memory array comprising a plurality of cells, wherein the receiving comprises setting a plurality of resistances on the plurality of cells, wherein each of the plurality of resistances... University Of Rochester

01/26/17 / #20170020462

Method and apparatus to diagnose the metastatic or progressive potential of cancer, fibrosis and other diseases

A method and apparatus for determining the progressive potential of a disease is disclosed. The forward to backward propagating second harmonic generation signal derived from a second harmonic generation instrument is used to assess the collagen microstructure of imaged body tissue by way of numerical values that are in turn... University Of Rochester

01/26/17 / #20170020474

Method and cone beam breast ct image-based computer-aided detection and diagnosis

Cone Beam Breast CT, (CBBCT) is a three-dimensional breast imaging modality with high soft tissue contrast, high spatial resolution and no tissue overlap. CBBCT-based computer aided diagnosis (CBBCT-CAD) technology is a clinically useful tool for breast cancer detection and diagnosis that will help radiologists to make more efficient and accurate... University Of Rochester

01/26/17 / #20170023569

Diagnostic device and detection of staphylococcus infection

Disclosed herein are diagnostic devices, kits, and methods for the detection of an active Staphylococcus infection in an individual. Utilizing a sample from the individual, antibodies specific for one or more Staphylococcus polypeptides are detected, where the detection of a threshold number of antibodies specific for one or more Staphylococcus... University Of Rochester

01/19/17 / #20170015610

Methods for producing butanol

Methods and compositions for producing 1-butanol are described herein. In some examples, the methods can comprise, contacting a reactant comprising ethanol with a catalyst system, thereby producing a product comprising 1-butanol. The catalyst system can comprise, for example, an iridium catalyst and a nickel, copper, and/or zinc catalyst. The nickel,... University Of Rochester

01/19/17 / #20170015735

Anti-glucosaminidase passive immunization for staphylococcus aureus infections

The present invention is directed to a monoclonal antibody that binds specifically to a Staphylococcus aureus glucosaminidase and inhibits in vivo growth of S. aureus. Also disclosed are monoclonal antibody binding portions, recombinant or hybridoma cell lines, pharmaceutical compositions containing the monoclonal antibody or binding portions thereof, and methods of... University Of Rochester

01/12/17 / #20170011797

Multistate register having a flip flop and multiple memristive devices

A multistate register, comprising: a flip-flop that comprises a first latch, a second latch and an intermediate gate coupled between the first and second latches; multiple memristive devices; and an interface coupled between the multiple memristive devices and the flip-flop; wherein the multistate register is arranged to operate in a... University Of Rochester

01/05/17 / #20170004344

Robust eye tracking for scanning laser ophthalmoscope

A system, apparatus, and method of obtaining an image of a fundus. Acquiring a reference image of the fundus at a first point in time. Acquiring a target image of the fundus at a second point in time. The target imaging area may overlap with the reference imaging area. An... University Of Rochester








ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009



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