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University Of South Florida patents


Recent patent applications related to University Of South Florida. University Of South Florida is listed as an Agent/Assignee. Note: University Of South Florida may have other listings under different names/spellings. We're not affiliated with University Of South Florida, we're just tracking patents.

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Human cord blood as a source of neural tissue repair of the brain and spinal cord

The present invention relates to the use of umbilical cord blood cells from a donor or patient to provide neural cells which may be used in transplantation. The isolated cells according to the present invention may be used to effect autologous and allogeneic transplantation and repair of neural tissue, in... University Of South Florida

System and measuring cell viability and growth

A novel SH-SAW biosensor capable of non-invasive and touch-free detection of cancer cell viability and growth or proliferation in two-dimensional (2D) and three-dimensional (3D) cell cultures as well as stem cell regeneration as it pertains to cancer cell biology and anti-cancer drug development is presented. The biosensor includes two pairs... University Of South Florida

Bis-cyclic guanidine compound compositions, methods of use and treatment thereof

The present disclosure provides compositions including a bis-cyclic guanidine compound, pharmaceutical compositions including a bis-cyclic guanidine compound, methods of treatment of a condition (e.g., bacterial infection) or disease, methods of treatment using compositions or pharmaceutical compositions, and the like.... University Of South Florida

System and electroporation controlled by electrical impedance measurements

The present invention provides a system and method for measuring the impedance of one more target cells before and after an electroporation protocol has been applied to the cells. The result of the impedance measurement provides a feedback control that can be implemented during and/or after the electroporation protocol to... University Of South Florida

Myricanol derivatives and uses thereof for treatment of neurodegenerative diseases

The subject invention pertains to myricanol derivatives, therapeutic compositions, and methods for treatment of neurodegenerative diseases, in particular, neurodegenerative diseases associated with abnormal accumulation of protein tau.... University Of South Florida

Cutin-like materials with advanced functionalities and methods of manufacture

Cutin-based devices, coatings and methods of producing such devices and coatings are presented herein. Cutin-like materials (CLMs) are presented which mimic and adapt coatings found in nature for the next generation of functional coatings. Cutin has several advantages including excellent UV resistance, natural resistance to bacteria and viruses, noncorrosive, and... University Of South Florida

Electronic catheter stethoscope

An electronic catheter stethoscope measures and analyzes acoustic fields and dynamic pressure variations in the gaseous or liquid fluid inside a conventional medical catheter that is positioned in a patient's urologic, digestive, reproductive, cardiovascular, neurological or pulmonary system. Measurement transducers are installed in a housing connectable to multiple preselected medical... University Of South Florida

Treating and/or preventing insulin-resistance related weight gain

Provided herein are methods of preventing or reducing weight gain in a subject in need thereof by administering 2-acetylcyclopentane-1,3-dione (ACPD).... University Of South Florida

Self-assembled targeted inclusion complexes for drug delivery

Inclusion complexes are provided containing a targeted carrier non-covalently associated with an active agent. The targeted carrier includes an inclusion host that binds the active agent or a binding partner attached to the active agent. The targeted carrier includes a targeting moiety attached to the inclusion host or to a... University Of South Florida

Bone fusion system

A method and system for performing bone fusion and/or securing one or more bones, such as adjacent vertebra, are disclosed. The screws include a threaded tip connected to a main shaft and a threaded outer sleeve that rotates relative to the outer shaft until locked down. Independent rotation of the... University Of South Florida

Systems and methods for treating dilute wastewater

In one embodiment, a dilute wastewater treatment system includes a separation subsystem configured to receive dilute wastewater and separate it into a product stream containing a low concentration of organic material and a reject stream containing a high concentration of organic material, and a conversion subsystem configured to receive the... University Of South Florida

Bk channel-modulating peptides and their use

The present invention concerns peptides and nucleic acids encoding the peptides, and their use for modulating large conductance Ca2+ activated K+ (BK) channel activity in cells; for treating conditions such as presbycusis (age-related hearing loss), audiogenic seizures, alcohol addiction, cancer, and neurodegenerative disease; and for delivering a cargo moiety to... University Of South Florida

Encapsulation of thermal energy storage media

In one embodiment, a method for depositing metal on a polymer surface, the method includes coating the polymer surface with a binding metal to render the polymer surface solvophillic and/or hydrophilic and depositing a further metal on the binding metal-coated polymer surface.... University Of South Florida

Method of treating colorectal cancers using a pkc inhibitor

The subject invention pertains to methods of treating colorectal cancer by administering an atypical PKC inhibitor. The inhibitors of aPKC useful in the methods of the instant invention include ACPD, ICA-1, DNDA and ζ-Stat. Also provided are methods of measuring the susceptibility of colon cancer cells of a subject to... University Of South Florida

Systems and methods for bubble based ion sources

The present disclosure describes embodiments directed to a bubble based ion source system comprising an ion source configured to generate a plurality of ions, an ion channel, an electrode, and/or any other components. The ion source can include a container at least partially comprising a solvent or solution, a bubble... University Of South Florida

Methods for making catechin derivatives

Disclosed herein are methods for making a catechin derivative, or a salt thereof. The methods can include: contacting an alcohol protected aromatic aldehyde and a triphenyl phosphonium ylide to make an alcohol protected aromatic olefin; hydrogenating the alcohol protected aromatic olefin to make alcohol protected aromatic compound; and deprotecting the... University Of South Florida

Metal oxide-based biocompatible hybrid sorbent for the extraction and enrichment of catecholamine neurotransmitters and related compounds, and synthesis

The subject invention concerns metal or metalloid oxide-based sol-gel hybrid sorbent and methods of synthesis. In one embodiment, the sorbent is a ZrO2 polypropylene oxide based sol-gel. The subject invention also concerns a hollow tube or capillary internally coated with a sorbent of the invention. Sorbent coated tubes and capillaries... University Of South Florida

Inflammatory disease diagnosis and methods of treatment using lipopolysaccharide-responsive beige-like anchor

Anti-cytokine therapy has revolutionized immunological disease treatment, but is not always effective and subject to treatment resistance as the cytokine cascade is highly redundant and multiple cytokines are involved in inflammation. Targeting a critical common regulator of inflammatory effectors is desirable. Lipopolysaccharide (LPS)-responsive beige-like anchor (LRBA) is a master regulator... University Of South Florida

Methods and compositions for cloning into large vectors

Provided herein are methods of cloning into vectors.... University Of South Florida

Methods of treating cognitive impairment

The subject invention concerns materials and methods for treating a person or animal having cognitive impairment. In one embodiment, the method comprises administering an effective amount of one or more inflammatory mediator(s), for example, fms-related tyrosine kinase 3 (Flt3) ligand, interleukin-6 (IL-6), macrophage migration inhibitory factor (MIF), interleukin-1 (IL-1), interleukin-3... University Of South Florida

Multiple-component solid phases containing at least one active pharmaceutical ingredient

The subject invention concerns a method for identifying complementary chemical functionalities to form a desired supramolecular synthon. The subject invention also pertains to multiple-component phase compositions comprising one or more pharmaceutical entities and methods for producing such compositions.... University Of South Florida

Method of treating melanoma using an inhibitor of an atypical protein kinase c

The invention pertains to a method of treating melanoma by administering to a subject in need thereof, a composition comprising a therapeutically effective amount of an inhibitor of PKC-ζ and/or PKC-ι. Non-limiting examples of an inhibitor of PKC-ζ and/or PKC-ι include ICA-1 and ACPD. The invention also provides PKC-ζ and/or... University Of South Florida

Methods and materials for capture antibody targeted fluorescent in-situ hybridization (cat-fish)

The subject invention concerns materials and methods for detecting a target cell in a population. Methods of the invention comprise internally labeling cells via fluorescence in situ hybridization (FISH) using probes that target rRNA, followed by binding of capture antibodies targeted (CAT) for specific cell surface epitopes on the target... University Of South Florida

Methods and compositions for diagnosis and management of diabetes and metabolic syndrome

Described herein are assays, methods, and devices for diagnosing/prognosing diabetes, metabolic syndrome, pre-diabetic state and/or the early-onset of diabetes in a subject. The assays, methods, and devices described herein can be configured to detect one or more long-coding RNAs in a sample from a subject.... University Of South Florida

Use of cotinine in treating or preventing neurogenesis deficits and enhancing neurogenesis

A method of inhibiting or treating chemotherapy-induced cognitive dysfunction comprising administering a therapeutically effective amount of cotinine to a cancer patient experiencing chemotherapy-induced cognitive dysfunction.... University Of South Florida

Compositions including triciribine and epidermal growth factor receptor inhibitor compounds or salts thereof and methods of use thereof

This application relates to combination therapies including triciribine compounds and epidermal growth factor receptor inhibitor compounds, particularly erlotinib-like compounds and compositions with reduced toxicity for the treatment and prevention of tumors, cancer, and other disorders associated with abnormal cell proliferation.... University Of South Florida

Supervised learning methods for the prediction of tumor radiosensitivity to preoperative radiochemotherapy

Disclosed is a gene expression panel that can predict radiation sensitivity (radiosensitivity) of a tumor in a subject. A method of predicting radiation sensitivity is provided that is based on cellular clonogenic survival after 2 Gy (SF2) for 48 cell lines. Gene expression is used as the basis of the... University Of South Florida

Pharmaceutical compounds and use of same in cancer and tauopathies

Disclosed are compounds of formula (I)-(V): where the substituents are as provided herein. Further disclosed are methods of inhibiting tau aggregation, treating or ameliorating a tauopathy or cancer by administration of such a compound. Tau is a microtubule-binding protein that accumulates in a number of neurodegenerative disorders, including frontotemporal dementia... University Of South Florida

Compositions and methods for producing elevated and sustained ketosis

Beta-hydroxybutyrate mineral salts in combination with medium chain fatty acids or an ester thereof such as medium chain triglycerides were used to induce ketosis, achieving blood ketone levels of (2-7 mmol/L), with or without dietary restriction. The combination results in substantial improvements in metabolic biomarkers related to insulin resistance, diabetes,... University Of South Florida

Transgenic mouse model for conditional fkbp51 expression and related methods

The subject invention pertains to transgenic non-human animals comprising a transgenic nucleotide sequence, integrated into the genome of the animals, comprising a nucleotide sequence encoding human FKBP51 operably linked to a tetracycline response element. In some embodiments, the transgenic animal comprises an additional transgenic nucleotide sequence, integrated into the genome... University Of South Florida

Magneto-dielectric polymer nanocomposites

In accordance with the present invention, novel superparamagnetic magneto-dielectric polymer nanocomposites are synthesized using a novel process. The tunability of the dielectric/magnetic properties demonstrated by this novel highly-viscous solvent-free polymer nanocomposite that is amenable to building 3D electromagnetic structures/devices by using processes such as 3D printing, compression molding or injection... University Of South Florida

Systems and methods for authentication using authentication votes

A system and method of authentication is described. In operation, an authenticator computing device receives a request to access a resource from a requesting user. In response to the request, the authenticator computing device generates and transmits an authentication vote query to one or more voting users, wherein the one... University Of South Florida

Arginine deiminase gene therapy for disordered proteins

The invention relates to compositions comprising arginine deiminase and their use in a method of reducing aggregation of disordered protein in a subject.... University Of South Florida

Methods of synthesizing gamma-aapeptides, gamma-aapeptide building blocks, gamma-aapeptide libraries, and gamma-aapeptide inhibitors of alpha-beta40 aggregates

Embodiments of the present disclosure provide for γ-AApeptides, γ-AApeptide building blocks, methods of making γ-AApeptides and libraries of γ-AApeptides, methods of screening the γ-AApeptide libraries for desired peptidomimetic activity, and the like. The present disclosure also provides for γ-AApeptides that are inhibitors of Aβ peptide aggregation, methods of inhibiting and... University Of South Florida

System and automated stereology of cancer

A system and method for applying an ensemble of segmentations to a tissue sample at a blob level and at an image level to determine if the tissue sample is representative of cancerous tissue. The ensemble of segmentations at the image level is used to accept or reject images based... University Of South Florida

08/17/17 / #20170237439

Wide operating level shifters

Aspects of wide operating range level shifter designs are described. One embodiment includes a level shifter configured to receive an input signal in a first voltage domain and generate an output signal in a second voltage domain, a pulse generator configured to generate a pulse in response to sensing a... University Of South Florida

08/10/17 / #20170224724

Ionic cocrystal of lithium, lispro, for the treatment of fragile x syndrome

The invention relates to a pharmaceutical composition comprising an ionic co-crystal (ICC) of lithium with salicylic acid and 1-proline (LISPRO). The pharmaceutical composition can further comprise an anti-inflammatory agent, for example, salicylic acid. An embodiment of the invention provides a method for treating Fragile X Syndrome (FXS) in a subject... University Of South Florida

08/10/17 / #20170225969

Porous organic polymers for binding heavy metals

Compositions containing a porous organic polymer and a heavy metal chelating moiety are provided for binding heavy metals, for example in remediation and purification. The compositions can be stable and recyclable. The compositions can contain heavy metal chelating moieties such as a thiol, a sulfide, an amine, a pyridine, or... University Of South Florida

08/03/17 / #20170216337

Compositions including triciribine and epidermal growth factor receptor inhibitor compounds or salts thereof and methods of use thereof

This application relates to combination therapies including triciribine compounds and epidermal growth factor receptor inhibitor compounds, particularly erlotinib-like compounds and compositions with reduced toxicity for the treatment and prevention of tumors, cancer, and other disorders associated with abnormal cell proliferation.... University Of South Florida

08/03/17 / #20170219564

Three-dimensional fibrous scaffolds for cell culture

Provided herein is a three-dimensional scaffold composition comprising randomly oriented fibers, wherein the fibers comprise a polyethylene glycol-polylactic acid block copolymer (PEG-PLA) and a poly(lactic-co-glycolic acid) (PLGA). Also provided are methods for using the three-dimensional scaffolds described herein.... University Of South Florida

07/27/17 / #20170214532

Magnetic memory physically unclonable functions

A magnetic random access memory (MRAM) physically unclonable function (PUF) device that uses the geometric variations in magnetic memory cells to generate a random PUF response is described herein. Within the MRAM, one or more magnetic memory cells can be used for the PUF. The PUF response is generated by... University Of South Florida

07/20/17 / #20170202659

Reversible anchoring devices

In one embodiment, a reversible anchoring device includes a base having a threaded shaft and an internal passage that extends through the base along a longitudinal direction of the base and a cap having a top surface, a bottom surface, a threaded circular opening formed in the bottom surface adapted... University Of South Florida

07/20/17 / #20170202795

Small molecule inhibitors of stat3 with anti-tumor activity

The present invention concerns compounds, compositions containing these compounds, and methods of using these compounds and compositions as inhibitors of Stat3 signaling, Stat3 dimerization, Stat3-DNA binding, Stat5-DNA binding, and/or aberrant cell growth in vitro or in vivo, e.g., as anti-cancer agents for treatment of cancer, such as breast cancer. The... University Of South Florida

07/20/17 / #20170202848

Afobazole nanoparticles formulation for enhanced therapeutics

A novel nanoparticle drug composition and method of use thereof is presented herein. The nanoparticle drug composition is comprised of at least one nanoparticle carrier, formed from the conjugation of PLGA and. PEG, which encapsulates a drug such as afobazole and its derivatives, in a pharmaceutically acceptable carrier. The nanoparticle... University Of South Florida

07/20/17 / #20170202902

Conjugates for immunotherapy

The current invention pertains to a molecular conjugate comprising an antagonist of a cell surface receptor specific to a target cell and an immune effector, such as a T cell modulator, conjugated to the antagonist. The target cell can be a cell responsible for development of a disease in a... University Of South Florida

07/13/17 / #20170196948

Methods, antibodies, and vaccines utilizing epitopes of alpha synuclein for treatment of parkinsons disease

The present invention pertains to a dendritic cell-based vaccine against rh-α-Syn, α-synuclein specific peptide antibodies and related vaccines, and methods of treating, preventing, and/or vaccinating against Parkinson's Disease (PD), or symptoms thereof.... University Of South Florida

07/06/17 / #20170188554

Animal model for studying complex human diseases

The invention concerns a non-human animal model useful for modeling complex human diseases; compositions comprising cell populations from the animal model having different genotypes for the same gene; methods for producing the animal model; and methods for studying a phenotype using an animal model or compositions of the invention.... University Of South Florida

07/06/17 / #20170189490

Methods of treating cognitive impairment

The subject invention concerns materials and methods for treating a person or animal having cognitive impairment. In one embodiment, the method comprises administering an effective amount of one or more inflammatory mediator(s), for example, fms-related tyrosine kinase 3 (Flt3) ligand, interleukin-6 (IL-6), macrophage migration inhibitory factor (MIF), interleukin-1 (IL-1), interleukin-3... University Of South Florida

06/29/17 / #20170181983

Exo-s-mecamylamine formulation and use in treatment

A pharmaceutical composition includes a therapeutically effective amount of exo-S-mecamylamine or a pharmaceutically acceptable salt thereof, substantially free of exo-R-mecamylamine in combination with a pharmaceutically acceptable carrier. Preferably the amount is about 0.5 mg to about 20 mg. Medical conditions are treated by administering a therapeutically effective amount of exo-S-mecamylamine... University Of South Florida

06/29/17 / #20170185697

Systems and methods for designing kinetic shapes

In one embodiment, a kinetic shape is designed by determining an applied force to be applied to an object that is to incorporate the kinetic shape, determining a reactive force that is desired to be produced in response to the applied force, inputting the applied force and the reactive force... University Of South Florida

06/22/17 / #20170172418

Standardized oral health assessment and scoring using digital imaging

System and methodology objectively capture clinical data on oral health and provide standardized scoring for quantifying oral health. The process of capturing clinical data is based on use of an intraoral camera with imaging software that has the capacity to capture digital images of all tooth surfaces. Digital plaque data... University Of South Florida

06/22/17 / #20170172969

Methods of sustaining dietary ketosis and its effects on lipid profile

The ketogenic diet (KD) has therapeutic implications in many disease states. It was hypothesized ketone precursor supplementation would elevate blood ketone levels to therapeutic ranges (2-7 mM) without need for dietary restriction. The effects of ketogenic agents were tested on blood glucose, ketones, and lipids with a 28-day dose escalation... University Of South Florida

06/22/17 / #20170173049

Withacnistin compounds for treatment of cancer

The subject invention pertains to the treatment of tumors and cancerous tissues and the prevention of tumorigenesis and malignant transformation through the modulation of STAT3 intracellular signaling. The subject invention concerns pharmaceutical compositions containing one or more withacnistin compounds, or a pharmaceutically acceptable salt or derivative thereof. In one embodiment,... University Of South Florida

06/22/17 / #20170173216

Collagen scaffolds, medical implants with same and methods of use

The subject invention concerns non-degradable three dimensional porous collagen scaffolds and coatings. These scaffolds can be prepared around sensors for implantation into a body. A specific embodiment of the invention concerns implantable glucose sensors. Sensors comprising a collagen scaffold of the invention have improved biocompatibility by minimizing tissue reactions while... University Of South Florida

06/22/17 / #20170173307

Novel non-invasive direct delivery of therapeutics to the spinal cord in the treatment of spinal cord pathology

Most spinal cord therapies are administered systemically, with only a small portion of the therapeutic reaching the spinal cord. A novel method for delivering therapeutics directly to the spinal cord is provided. The method uses a duel-balloon catheter to isolate the microvasculature around a region of the spinal cord. Once... University Of South Florida

06/22/17 / #20170174726

Stabilized peptoid-peptide hybrids and uses thereof

The current invention pertains to stabilized peptoids or peptoid-peptide hybrids. The peptoids or peptoid-peptide hybrids are stabilized by side chain-side to side chain linkages and/or backbone cyclization. The current invention also provides a positional library scanning method for identification of peptoids or peptoid-peptide hybrids having a desired biological activity.... University Of South Florida

06/08/17 / #20170157571

Electrospun cactus mucilage nanofibers

Novel electrospun nanofibers and nanofibrous membranes, methods of manufacturing the same, and methods of using the same are provided. The nanofibers include a cactus mucilage, such as mucilage from Opuntia ficus-indica. An organic polymer can be added to the cactus mucilage before electrospinning. The nanofibrous membranes can be used in... University Of South Florida

05/25/17 / #20170143769

Human umbilical cord blood-derived monocytes for treatment of neurodegenerative diseases and disorders

Human umbilical cord blood-derived monocytes that markedly promote Aβ clearance through heterodimerization of sAPPα with Aβ and resultant sAPPα production for prevention or treatment of Alzheimer's disease and other neurodegenerative disorders (including stroke and TBI). It was discovered that multiple low-dose infusions of human umbilical cord blood cells (HUCBCs) ameliorate... University Of South Florida

05/25/17 / #20170144099

Metal-organic materials (moms) for co2 adsorption and methods of using moms

Embodiments of the present disclosure provide for metal-organic materials (MOMs), systems that exhibit permanent porosity and using hydrophobic MOMs to separate components in a gas, methods of separating CO2 from a gas, and the like.... University Of South Florida

05/25/17 / #20170145681

Shape-morphing space frame apparatus using unit cell bistable elements

Unit cell bistable elements, and particular arrangements thereof, that can transform or morph a structure from one shape to another. In certain embodiments, the current invention includes unit cell bistable elements, and particular arrangements and uses thereof, that can transform or morph a structure from one shape to another. In... University Of South Florida

05/18/17 / #20170137812

Compositions and methods for modulating myeloid derived suppressor cells

Provided are methods of treating an inflammatory disease in a subject in need thereof by administering an amount of microRNA 142, an amount of microRNA 223 or an amount of microRNA 142 and an amount of micro RNA 223 to the subject in need thereof.... University Of South Florida

05/18/17 / #20170140672

Radial arm model with mesh

A radial arm model in combination with a two-way mesh to permit puncturing, dissection/transection, and suturing of the underlying simulation vessels. The current invention also includes a method of training for such a procedure using said model, along with a method of fabricating or manufacturing such a model.... University Of South Florida

04/27/17 / #20170113204

Metal-organic materials for c02 adsorption

Embodiments of the present disclosure provide for metal-organic materials (MOMs), systems that exhibit permanent porosity and using hydrophobic MOMs to separate components in a gas, methods of separating CO2 from a gas, and the like.... University Of South Florida

04/20/17 / #20170106019

Compositions and methods for mitigating drug resistant bacteria

The current invention is a broad-based remediation mechanism against MRFs and includes nanotechnology formulations and methodologies that may be used to develop novel mitigation strategies against certain drug resistant bacterial strains. In an embodiment, the current invention relates to mitigation of drug resistant bacteria from nosocomial infections, for example in... University Of South Florida

04/20/17 / #20170108829

Systems and methods for performing self-interference incoherent digital holography

In one embodiment, a self-interference incoherent digital holography system including a light sensor and a diffractive filter configured to receive light from an object to be holographically imaged and generate holographic interference patterns on the light sensor. A self-interference incoherent digital holography system comprising: a light sensor; and a diffractive... University Of South Florida

Patent Packs
04/13/17 / #20170100506

Protease resistant growth factor formulations for chronic wound healing

A formulation and method of treating chronic wounds is presented. The formulation uses two different fusion peptides, one of which incorporates an elastase resistant peptide, to preserve the bioactivity of different functional peptides and growth factors in chronic wounds.... University Of South Florida

04/13/17 / #20170101439

Gamma-aa-peptide stat3/dna inhibitors and methods of use

STAT3 hyperphosphorylation, dimerization and DNA binding are required for its ability to contribute to malignant transformation. As such, STAT3 has been recognized as a promising target for cancer therapy. Although a number of inhibitors of STAT3-STAT3 dimerization have been reported, molecular ligands that prevent interactions between STAT3 and DNA are... University Of South Florida

03/30/17 / #20170088524

Compositions, methods of use, and methods of treatment

Embodiments of the present disclosure, in one aspect, relate to a beta-lactamase inhibitor, pharmaceutical compositions including a beta-lactamase inhibitor, methods of treatment of a condition (e.g., infection) or disease, methods of treatment using compositions or pharmaceutical compositions, and the like.... University Of South Florida

03/23/17 / #20170080007

Effective treatment of esophageal adenocarcinoma using triciribine and related compounds

The inventors have determined, contrary to the prior art and experience, how to successfully use triciribine to treat esophogeal adenocarcinoma by one or a combination of (i) administering triciribine only to patients which according to a diagnostic test described below, exhibit enhanced sensitivity to the drug; (ii) use of a... University Of South Florida

03/23/17 / #20170081225

Portable wastewater treatment systems

In one embodiment, a portable wastewater treatment system includes an anaerobic reactor in which organic material within the wastewater can be broken down, a membrane filter that receives wastewater from the anaerobic reactor and filters the water to produce permeate, and a small shipping container in which the reactor and... University Of South Florida

03/23/17 / #20170081635

Tumor-infiltrating lymphocytes for adoptive cell therapy

Disclosed are compositions and methods for ex vivo expansion of tumorinfiltrating lymphocytes for use in adoptive cell therapy (ACT). Also disclosed are compositions and method for identifying an agent for ex vivo expansion of tumorinfiltrating lymphocytes for use in ACT. Also disclosed are methods for treating cancer using tumor-infiltrating lymphocytes... University Of South Florida

03/23/17 / #20170082602

Systems and methods for analyzing liquids

In one embodiment, an optical spectroscopy probe includes an optical fiber having a distal tip and a microfluidic filtering chamber attached to the distal tip of the optical fiber, the chamber comprising a microfluidic membrane adapted to enable liquid to enter the chamber but prevent particles from entering the chamber.... University Of South Florida

03/16/17 / #20170071496

Radiologically identified tumor habitats

Virtually every cancer patient is imaged with CT, PET or MRI. Importantly, such imaging reveals that tumors are complex and heterogeneous, often containing multiple habitats within them. Disclosed herein are methods for analyzing these images to infer cellular and molecular structure in each of these habitats. The methods can involve... University Of South Florida

03/16/17 / #20170071566

Electronic catheter stethoscope

An electronic catheter stethoscope measures and analyzes acoustic fields and dynamic pressure variations in the gaseous or liquid fluid inside a conventional medical catheter that is positioned in a patient's urologic, digestive, reproductive, cardiovascular, neurological or pulmonary system. Measurement transducers are installed in a housing connectable to multiple preselected medical... University Of South Florida

03/09/17 / #20170065564

Bis-cyclic guanidine compound compositions, methods of use and treatment thereof

The present disclosure provides compositions including a bis-cyclic guanidine compound, pharmaceutical compositions including a bis-cyclic guanidine compound, methods of treatment of a condition {e.g., bacterial infection) or disease, methods of treatment using compositions or pharmaceutical compositions, and the like.... University Of South Florida

03/09/17 / #20170065643

Method of stem cell delivery into the brain during chronic disease using blood brain barrier permeabilizers

Blood brain barrier (BBB) permeabilizers, such as mannitol, can facilitate the entry of stem cells from the periphery to the stroke brain. It is unknown whether BBB permeation in the chronic stage of the disease still facilitates the entry of stem cells from the periphery to the injured brain. Evidence... University Of South Florida

03/09/17 / #20170067005

Concentrically baffled reactors and systems that incorporate them

In one embodiment, a concentrically baffled reactor includes an outer housing that defines an interior space, an inlet through which material can be delivered into the interior space, an outlet through which material can be removed from the interior space, and multiple concentric baffles within the interior space that define... University Of South Florida

03/02/17 / #20170056337

Antibacterial s-heterosubstituted disulfides

Synthetically-derived S,S-heterodisubstituted disulfides that exhibit potent in vitro antibacterial activity against a variety of bacteria, including Staphylococcus aureus, methicillin-resistant Staphylococcus aureus and Francisella tularensis. The present invention provides compounds, methods and compositions effective to treat microbial/bacterial infections, and, especially, infections arising from bacteria which have developed resistance to conventional antibiotics.... University Of South Florida

03/02/17 / #20170058002

Gamma-aapeptides with potent and broad-spectrum antimicrobial activity

The present invention is directed to a novel class of antimicrobial agents called γ-AApeptides. The current invention provides various categories of γ-AApeptides, for example, linear γ-AApeptides, cyclic γ-AApeptides, and lipidated γ-AApeptides. γ-AApeptides of the current invention are designed to exert antimicrobial activity while being stable and non-toxic. γ-AApeptides also do... University Of South Florida

03/02/17 / #20170058264

Formation of multicellular tumoroids and uses thereof

Described herein are compositions and methods of forming multi-cellular tumoroids. Also described herein are methods of using the multi-cellular tumoroids.... University Of South Florida

Patent Packs
03/02/17 / #20170058432

Polypeptide electrospun nanofibrils of defined composition

Electrospun nanofibrils and methods of preparing the same are provided. The electrospun nanofibrils comprise at least one polypeptide. A polypeptide can be dissolved in a solution, and the solution can be electrospun into a nanofibril. The solution can be added to a syringe or syringe pump, and an electric field... University Of South Florida

03/02/17 / #20170060417

Magnetic coprocessor and use

A magnetic system for solving a quadratic optimization problem by associating each of a plurality of variables of a quadratic optimization problem with a nanomagnet of a nanomagnet array, driving the nanomagnets of the nanomagnet array to an excited state, allowing the nanomagnets of the nanomagnet array to enter a... University Of South Florida

03/02/17 / #20170062072

Physically unclonable function based on domain wall memory and use

A system and method for providing a physically unclonable function (PFU) is described. In operation, the method includes applying a domain wall shift pulse challenge to a plurality of nanowires of a domain wall memory (DWM) array, wherein the nanowires of the domain wall memory (DWM) array have process induced... University Of South Florida

02/23/17 / #20170050029

Magnetic resonant imaging safe stylus

An implantable magnetic resonant imaging (MRI) safe stylus for biomedical devices is described. In one example, the stylus includes a set of stylus modules. One or more of the stylus modules includes a core rod formed of silicon carbide (SiC) material, a recording array mounted on the core rod, and... University Of South Florida

02/23/17 / #20170050946

Antimicrobials from an epigenetics based fungal metabolite screening program

Novel antimicrobial compounds and associated methods of development are presented herein.... University Of South Florida

02/16/17 / #20170042927

Effective treatment of ovarian cancer using triciribine and related compounds

The inventors have determined, contrary to the prior art and experience, how to successfully use triciribine to treat ovarian cancer by one or a combination of (i) administering triciribine only to patients which according to a diagnostic test described below, exhibit enhanced sensitivity to the drug; (ii) use of a... University Of South Florida

02/16/17 / #20170044225

Amyloid precursor protein (app) based β-secretase inhibitor peptides, and methods of use

The present invention provides fusion peptides, compositions, methods and kits for treating, reducing the risk of, lessening the severity of, preventing, or delaying the onset of amyloid-related disorders, such as Alzheimer's disease and HIV associated neurocognitive impairment.... University Of South Florida

02/16/17 / #20170044690

Polypeptide electrospun nanofibrils of defined composition

Electrospun nanofibrils and methods of preparing the same are provided. The electrospun nanofibrils comprise at least one polypeptide. A polypeptide can be dissolved in a solution, and the solution can be electrospun into a nanofibril. The solution can be added to a syringe or syringe pump, and an electric field... University Of South Florida

02/09/17 / #20170039892

Synthetic vaginal cuff model and simulating vaginal cuff closure

A vaginal cuff surgical model and methods of manufacture and use thereof. The model includes a body (resembling a vaginal cuff) and appendages (resembling uterosacral ligaments) extending from the body. The model (body and appendages) is formed of silicone, rubber, a polymer, or other suitable material with one or more... University Of South Florida

01/26/17 / #20170020826

Stabilization of alcohol intoxication-induced cardiovascular instability

The present invention concerns use of an agent that increases sphingosine-1-phosphate (S1P) receptor activity, such as S1P, or an S1P receptor agonist, for treatment of alcohol-intoxicated subjects will help stabilize blood pressure and improve resuscitation efforts in alcohol-intoxicated subjects, including alcohol-intoxicated trauma patients. Another aspect concerns a kit for stabilization... University Of South Florida

01/26/17 / #20170022540

Bioink for three-dimensional biomaterial printing

A method of creating “bioink” has been proposed, which increases the shelf-life and transportability of biological materials for use in bioprinting applications. The current invention also contemplates a composition of biomaterials admixed with trehalose to dehydrate the biomaterials for preservation and transportation. The dehydrated biomaterials can then be rehydrated for... University Of South Florida

01/19/17 / #20170018308

Mtj-based content addressable memory

Embodiments of the subject invention provide a three transistor, two domain-wall-based magnetic tunnel junction CAM cell (3T-2DW-MTJ CAM). A four transistor, two magnetic tunnel junction ternary CAM cell (4T-2MTJ TCAM) is also provided. An array of the provided CAM cells forms words of various lengths, such as 4-bit, 8-bit, and... University Of South Florida

01/19/17 / #20170019284

Joint physical layer security and papr mitigation in ofdm sytems

Systems and methods for securing orthogonal frequency division multiplexing (OFDM) transmission of data are discussed herein. Transceivers can sense the signal strength of frequencies on an OFDM wireless channel. The transceivers can determine which of the frequencies are fading frequencies failing below a threshold. A transmitting transceiver can send artificial... University Of South Florida

01/05/17 / #20170000612

Osteoconductive and osteoinductive implant for augmentation, stabilization, or defect reconstruction

Aspects of the present invention provide implants for augmentation, stabilization, or defect reconstruction of bone tissue, comprising a scaffold portion structured to provide shape to the implant, the scaffold portion comprising one or more of the following: one or more polylactic acid isomer; one or more polyglycolic acid isomer; and/or... University Of South Florida

01/05/17 / #20170000630

Universal multi-branch endograft

The present invention provides endovascular stent graft conversion devices, systems and related methods that are particularly useful in aortic aneurysm repair, such as, but not limited to, thoraco-abdominal aortic aneurysm (TAAA) repair. The endovascular stent graft conversion device provided by the present invention comprises a graft segment comprising a first... University Of South Florida

01/05/17 / #20170000754

Ketone supplements for treatment of angelman syndrome

The invention concerns a method of treating Angelman Syndrome (AS) in a subject, comprising inducing ketosis in the subject by administering a therapeutically effective amount of a ketone ester, such as an R,S-1,3-butanediol acetoacetate ester, wherein administration of the ketone ester elevates the blood ketone level in the subject. Other... University Of South Florida

01/05/17 / #20170000785

Inhibitors of the fkbp51 protein from a high-throughput drug screen and methods of use

The subject invention concerns materials and methods for treating depression, stress disorders, such as PTSD, anxiety disorders, and/or a neurodegenerative disease or condition in a person or animal. In one embodiment, a person or animal in need of treatment is administered one or more compounds or drugs, or a composition... University Of South Florida

01/05/17 / #20170002317

Conversion of non-neuronal cells into neurons

The subject invention concerns materials and methods for conversion of non-neuronal cells into neurons. The subject invention also concerns methods for screening drugs and other compounds for activity in treating Alzheimer's disease using neuronal cells produced using the subject invention. The subject invention also concerns neuronal cells that have been... University Of South Florida

01/05/17 / #20170004868

Robust slope detection technique for sttram and mram sensing

Slope detection systems and methods are provided that monitor magnetic tunnel junction (MTJ) resistance switching. A low-overhead, sample-and-hold circuit can be used. Slope detection techniques can reduce or eliminate bit-to-bit process variation, thereby reducing or eliminating variation in oxide thickness. In addition, the need for data and reference current can... University Of South Florida

10/05/17 / #20170283344

Systems and methods for producing liquid fuels from landfill gases

In some embodiments, a system for producing liquid fuel from landfill gas includes a tri-reformer that receives landfill gas and produces synthesis gas having a H2:CO ratio of approximately 2:1, and a Fischer-Tropsch synthesis (FTS) reformer that receives the synthesis gas from the tri-reformer and produces liquid fuel.... University Of South Florida

08/03/17 / #20170219564

Three-dimensional fibrous scaffolds for cell culture

Provided herein is a three-dimensional scaffold composition comprising randomly oriented fibers, wherein the fibers comprise a polyethylene glycol-polylactic acid block copolymer (PEG-PLA) and a poly(lactic-co-glycolic acid) (PLGA). Also provided are methods for using the three-dimensional scaffolds described herein.... University Of South Florida








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