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University Of Utah Research Foundation
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University Of Utah Research Foundation patents


Recent patent applications related to University Of Utah Research Foundation. University Of Utah Research Foundation is listed as an Agent/Assignee. Note: University Of Utah Research Foundation may have other listings under different names/spellings. We're not affiliated with University Of Utah Research Foundation, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "U" | University Of Utah Research Foundation-related inventors


Methods for diagnosing and monitoring eosinophilic esophagitis

Disclosed are compositions and methods for diagnosing eosinophilic esophagitis in a subject. Also disclosed are methods for monitoring the course of eosinophilic esophagitis in a subject before, during, and after treatment. In another aspect, disclosed is a method of diagnosing eosinophilic esophagitis or eosinophilic diseases in a subject, comprising detecting... University Of Utah Research Foundation

Temperature profile for rock sample composition analysis

A method for analyzing the petroleum content of a rock sample includes at least three repetitions of heating a rock sample to a holding temperature, holding the rock sample at the holding temperature for a holding period, and collecting data about the rock sample during each holding period. The holding... University Of Utah Research Foundation

Methods of detecting analytes and diagnosing tuberculosis

A method for detecting lipoarabinomannan in a biological sample is described, including the step of contacting the biological sample with at least one acid selected from the group consisting of perchloric acid, trifluoroacetic acid, and sulfosalicylic acid. Methods for diagnosing diseases, including tuberculosis, and kits for the described methods are... University Of Utah Research Foundation

Hdac1,2 inhibitors and methods of using the same

Disclosed herein are methods for treating a cancer and a method for sensitizing a cancer to a chemotherapeutic agent. Each method administers an agent that selectively inhibits HDAC1 and HDAC2 to a subject in need thereof. Also disclosed herein are methods for determining if a cancer is sensitive to an... University Of Utah Research Foundation

Skin stretch feedback devices, systems, and methods

Embodiments of the present disclosure relate devices, systems, methods, and for displaying information about the direction and magnitude of position, movement, and/or resistive force experienced for an object. The present disclosure also provides a shear display device that can generate skin shear with one or more tactors. The movement of... University Of Utah Research Foundation

Compositions and methods for peptide expression and purification using a type iii secretion system

Disclosed are compositions and methods for expressing and purifying a peptide of interest using a Flagellar Type III secretion system. Disclosed are nucleic acid sequences that contain a FlgM nucleic acid sequence, a cleavage site, and a nucleic acid sequence of interest. Also disclosed are polypeptides that contain FlgM, a... University Of Utah Research Foundation

Organism identification panel

Methods and containers are provided for identifying a species, illustratively a bacterial species. Illustrative methods comprise amplifying various genes in the nucleic acid from the bacterial species in a single reaction mixture using pairs of outer first-stage primers designed to hybridize to generally conserved regions of the respective genes to... University Of Utah Research Foundation

Dimeric collagen hybridizing peptides and methods of using

Disclosed are peptide conjugates comprising an active agent, a spacer moiety, and a dimeric collagen hybridizing peptide comprising a first and second collagen hybridizing peptide, a linker; and a branch point, wherein the first and second collagen hybridizing peptides comprise the sequence of at least (GXY)n, wherein G is glycine,... University Of Utah Research Foundation

Bi-functional allosteric protein-drug molecules for targeted therapy

Disclosed herein, is a bi-functional allosteric protein-drug molecule comprising a targeting moiety, one or more biological binding domains, and one or more therapeutic agents, wherein the therapeutic agent is allosterically bound to the biological binding domain. Also described herein, are methods of incorporating a bi-functional allosteric protein-drug molecule comprising a... University Of Utah Research Foundation

Spinal cord stimulation system

A method for optimizing the stimulation of the dorsal column of the spinal cord is disclosed. The method includes providing a stimulating electrode array and a frame element. The frame element is configured to couple to the stimulating electrode array and guide the stimulating electrode array to a desired position... University Of Utah Research Foundation

Trizol-1-ol analogs anti-retroviral latency drugs

In one aspect, the invention relates to triazol-1-ol compounds, analogs thereof, compositions comprising same, and methods of using same, alone or in combination with other agents, to reactivate latent retroviruses, and more particularly to reactivate latent HIV-1. Such compounds, compositions, and methods can be used, for example, in connection with... University Of Utah Research Foundation

Nanodiamond supported catalytic nanoparticles and associated methods

A catalytic nanoparticle can include a nanodiamond core, a thin-layer polymeric film applied to an outer surface of the nanodiamond core, and a catalyst immobilized at an outer surface of the thin-layer polymeric film. The nanoparticles can also be used in connection with a transducer to form a sensor. A... University Of Utah Research Foundation

Polyphosphate hydrogels and methods of making and using thereof

Described herein are hydrogels with improved mechanical properties. The hydrogels are composed of two polymer networks covalently crosslinked with one another. The addition of a multivalent cation and/or polycation to the hydrogels further crosslinks the polyphosphate network and can modulate the mechanical properties of the hydrogels as needed. Methods for... University Of Utah Research Foundation

Climate control system and associated methods

A climate control system is described that can include a thermal battery (100) with a heating bed (110) and cooling bed (120) and a conditioned air manifold adapted to direct heat transfer fluid across at least one of the heating bed (110) and the cooling bed (120) to condition inlet... University Of Utah Research Foundation

Methods for creating cadmium telluride (cdte) and related alloy film

A method of creating cadmium telluride films is presented. The method demonstrates heterogeneous nucleation of CdTe directly on a substrate through sequential deposition of aqueous precursor solutions containing cadmium and telluride ions, respectively. The method can include (i) applying a cadmium precursor solution to the substrate to form a cadmium... University Of Utah Research Foundation

Patient specific scan parameters for mri scanning

A method of optimizing scan parameters for LGE-MRI. At least one cardiac MRI TI scout scan is performed by applying an inversion pulse every predetermined heartbeat of a patient. An initial value of an inversion time TIinitial is determined by assessing a set of images generated from the scout scan.... University Of Utah Research Foundation

Ultra-low power digital chemical analyzers

A zero-power digital chemical analyzer can include a chemically-selective percolation switch. The chemically selected percolation switch can include a positive electrode and a negative electrode separated from the positive electrode by a gap. A binding agent can be located at binding sites in the gap. The binding agent can be... University Of Utah Research Foundation

Induced pluripotent stem cell and producing the same

The disclosure provides an episome comprising OCT4, KLF4, SOX2, cMYC, NANOG, LIN28, and NRSA2. Also disclosed is a method for producing an induced pluripotent stem (iPS) cell. The method comprises introducing an episome into a cell, wherein the episome comprises OCT4, KLF4, SOX2, cMYC, NANOG, LIN28, and NRSA2, and growing... University Of Utah Research Foundation

Systems and methods for distributed computing

A distributed computing manager provides access to computing resources of a plurality of separate computing systems. The distributed computing manager emulates the distributed computing resources as a unitary computing system comprising an emulated processor, I/O, memory, and so on. The distributed computing manager distributes instructions, I/O requests, memory accesses, and... University Of Utah Research Foundation

Multi-echo pseudo-golden angle stack of stars thermometry with high spatial and temporal resolution using k-space weighted image contrast

A method for producing an image of a subject using a magnetic resonance imaging (MRI) system includes acquiring a series of echo signals by sampling k-space along radial lines that each pass through the center of k-space. Each projection of the radial lines is divided into multiple echoes and successive... University Of Utah Research Foundation

Disease therapy game technology

A video game in possession of and/or in the proximity of a patient. The patient computing system receives an indication that it is to begin a game, and executes the game using identified game parameters that are associated with the patient by a clinician as part of a disease therapy... University Of Utah Research Foundation

Electronic peripheral nerve stimulation

A technology is described for an electronic peripheral nerve stimulation system. The electronic nerve stimulation system can include a stimulation device and an electrode array. The stimulation device can be operable to generate a high-frequency alternating current. The electrode array can be operable to apply the high-frequency alternating current received... University Of Utah Research Foundation

Monochrome multiplex quantitative pcr

Disclosed herein are methods and compositions for determining the copy number of a first target nucleic acid as compared to the copy number of a second target nucleic acid in a single well with a single detection label. For example, disclosed herein are methods and compositions for determining the copy... University Of Utah Research Foundation

Methods of treating hypoxia-associated optical conditions with cartilage oligo matrix protein-angiopoietin 1 (comp-ang1)

Methods, compositions, and systems for treating ischemia-associated and other ocular conditions using cartilage oligo matrix protein-Angiopoietin 1 (COMP-Ang1) are disclosed and described.... University Of Utah Research Foundation

Tissue sample processing system and associated methods

A tissue sample processing system and associated methods is disclosed and described. The tissue sample processing system (100) can include a microfluidic separating system (110). The microfluidic separating system (110) can include a fluid channel to receive a carrier fluid (104) and a tissue sample (102), and a plurality of... University Of Utah Research Foundation

Cardiac mapping catheter

A basket style electrical mapping catheter includes an elongated body with a proximal end and a distal end, where the proximal end has a user interface for controlling a basket-shaped electrode assembly that extends from the distal end of the elongated body. The basket-shaped electrode assembly includes a plurality of... University Of Utah Research Foundation

Compositions and methods for bile acid particles

Therapeutic compositions are disclosed which contain a therapeutic agent and a bile acid or bile acid conjugate. The compositions can be absorbed via enterohepatic circulation. The compositions include a cationic moiety and an anionic polymer, which are coupled through electrostatic interactions. The therapeutic compositions can be used for the treatment... University Of Utah Research Foundation

Method of producing n-alkyl polyamines

In one embodiment, the invention presents a process for the preparation of N-alkyl polyamines that includes (i) the conversion of an amino alcohol to an aminoalkyl alkylating agent with a halo or aldehyde reactive group and (ii) the addition of amines to an amine-containing alkylating agent to make an N-alkyl... University Of Utah Research Foundation

Molecular diagnosis and typing of lung cancer variants

Compositions and methods useful in determining the major morphological types of lung cancer are provided. The methods include detecting expression of at least one gene or biomarker in a sample. The expression of the gene or biomarker is indicative of the lung tumor subtype. The compositions include subsets of genes... University Of Utah Research Foundation

Methods for delivering an anti-cancer agent to a tumor

exposing the tumor to light for a sufficient time and wavelength in order for the gold particles to achieve surface plasmon resonance and heating the tumor.... University Of Utah Research Foundation

Multi-spectral imaging with diffractive optics

A multi-spectral imaging (MSI) device can include an imaging plane and a diffractive optic. The imaging plane can include at least two groups of pixels an array of pixels for sensing at least two spectral bands. The at least two spectral bands can include a first spectral band and a... University Of Utah Research Foundation

Uterine contraction device

The present disclosure describes a uterine contraction device which may be utilized to treat and/or prevent postpartum hemorrhaging. The uterine contraction device includes a catheter and a pressure seal adjustably coupled to the catheter. A distal section of the catheter is configured for insertion into the uterus, and a proximal... University Of Utah Research Foundation

Electronic nerve stimulation

A technology is described for an electronic nerve stimulation system. The electronic nerve stimulation system can include a stimulation device operable to generate a high-frequency alternating current. The electronic nerve stimulation system can include one or more wearable electrodes operable to apply the high-frequency alternating current from the stimulation device... University Of Utah Research Foundation

Substituted 1-h-indol-3-yl-benzamide and 1, 1'-biphenyl analogs as histone demethylase inhibitors

Substituted 1-H-indol-3-yl-benzamide and 1, 1′-biphenyl analogs derivatives thereof, and related compounds, which are useful as inhibitors of lysine-specific histone demethylase, including LSD1; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds and compositions to treat disorders associated with dysfunction of the LSD1.... University Of Utah Research Foundation

Method and system for data streaming

A technology is disclosed and described for distributing data packets. An example method may include creating a network connection between a source node and a gatherer server. Identifying a forwarder node available to connect to the source node via a wireless network. Sending connection protocol information to the forwarder node... University Of Utah Research Foundation

09/21/17 / #20170267729

Vaccine antigens that direct immunity to conserved epitopes

A method of identification and elimination of immunodominant epitopes to elicit a response to secondary epitopes, especially conserved structures, is described, and applied to influenza haemagglutinin (HA). Identification of the primary epitopes in (HA), and replacement of amino acids having high LODrps with corresponding low LODrps amino acids produces an... University Of Utah Research Foundation

08/31/17 / #20170247418

Ebolavirus pre-hairpin intermediate mimics and methods of use

Ebolavirus is a highly lethal filovirus that causes hemorrhagic fever in humans and non-human primates. With no approved treatments or preventatives, the development of an anti-ebolavirus therapy to protect against natural infections and potential weaponization is an urgent unmet global health need. The design, biophysical characterization, and validation of peptide... University Of Utah Research Foundation

08/24/17 / #20170239212

Bryostatin analogs and use thereof as antiviral agents

Described herein are tricyclic macrolactones. The macrolactones have a high binding affinity for PKC. The compounds described herein can be used in a number of therapeutic applications including the treatment or prevention of viral infection. Also described herein are methods for producing macrolactones. The methods permit the high-yield synthesis of... University Of Utah Research Foundation

08/24/17 / #20170239272

Intraocular drug delivery device and associated methods

An intraocular active agent delivery device can include an active agent homogenously combined with a biodegradable active agent matrix such that the entire delivery device is homogenous. The homogenous delivery device can have a shape and size to fit within a lens capsule or ciliary sulcus of an eye and... University Of Utah Research Foundation

08/24/17 / #20170239364

Methods and compositions related to inhibition of viral entry

Disclosed herein are compositions and methods for inhibiting viral entry.... University Of Utah Research Foundation

08/24/17 / #20170241961

Micro circulatory gas chromatography system and method

A gas chromatography system can include a circulatory loop, a gas inlet positioned along the circulatory loop, a gas outlet positioned along the circulatory loop, a micro column positioned in line with the circulatory loop, and an in-line population sensor positioned in line with the circulatory loop. The in-line population... University Of Utah Research Foundation

08/24/17 / #20170244042

Organic light-emitting apparatus

An organic light-emitting apparatus includes an organic light-emitting device and a magnetic field-applying member that applies a magnetic field to the organic light-emitting device. The organic light-emitting device includes a host and a dopant.... University Of Utah Research Foundation

08/24/17 / #20170244392

Relative timed clock gating cell

Technology is described for a relative timed clock gated cell. In one example, the relative timed clock gated cell includes a trigger latch and a data clock latch. The trigger latch includes a clock input coupled to a trigger line for transmitting a trigger signal. The trigger latch is configured... University Of Utah Research Foundation

08/17/17 / #20170233269

Water treatment device

A water treatment device (100) can include a chamber (104) having an inlet (108) to receive water contaminated with pathogens and an outlet (110) to dispense treated water. The water treatment device (100) can also include a catalytic element (130) disposed in the chamber (104) to deactivate the pathogens in... University Of Utah Research Foundation

08/10/17 / #20170226573

Nucleic acid melting analysis with saturation dyes

Methods are provided for nucleic acid analysis wherein a target nucleic acid is mixed with a dsDNA binding dye to form a mixture. Optionally, an unlabeled probe is included in the mixture. A melting curve is generated for the target nucleic acid by measuring fluorescence from the dsDNA binding dye... University Of Utah Research Foundation

08/03/17 / #20170218363

Morpholino-mediated increase in soluble flt-1 expression results in decreased ocular and tumor neovascularization

Methods of inhibiting lymphangiogenesis and/or angiogenesis in a subject are provided. In one aspect, for example, a method of inhibiting angiogenesis in a subject can include binding an antisense morpholino to an mRNA splicing site of VEGFR1 selected from exon13_intron13 junction, intron13_exon14 junction, or a combination thereof. In another aspect,... University Of Utah Research Foundation

08/03/17 / #20170218375

Morpholinos, morpholino upregulating, and associated methods

Various methods and compositions relating to vascular endothelial growth factor receptor 2 (VEGFR2) are provided. In one aspect, a method of increasing expression of the soluble form of VEGFR2 (sVEGFR2) in a subject can include binding an antisense morpholino to an exon13-intron13 splicing site of VEGFR2 mRNA such that the... University Of Utah Research Foundation

07/27/17 / #20170209084

Diagnosis of affective disorders using magnetic resonance spectroscopy neuroimaging

A method for facilitating diagnosis of an affective disorder in a person can include (a) acquiring 1H spectroscopic data to obtain an indicator of total choline (tCho) and creatine (Cr) in an area, e.g., the anterior cingulate cortex, of the person's brain; and (b) determining, by a processor and based... University Of Utah Research Foundation

06/22/17 / #20170174750

Peptide inhibitors of bcr-abl oligomerization

In one aspect, the invention relates to peptides comprising the Bcr-Abl coiled-coil oligomerization domain and an alpha helix stabilizing moiety, mutant forms thereof, truncated forms thereof, derivatives thereof, and related peptides, which are useful as inhibitors of the Bcr-Abl chimeric protein; pharmaceutical compositions comprising the compounds; and methods of treating... University Of Utah Research Foundation

06/22/17 / #20170175113

Methods for modulating ataxin 2 expression

Disclosed herein are methods for decreasing Ataxin 2 mRNA and protein expression. Such methods are useful to treat, prevent, or ameliorate Ataxin 2 associated diseases, disorders, and conditions. Such Ataxin 2 associated diseases include spinocerebellar ataxia type 2 (SCA2), amyotrophic lateral sclerosis (ALS), and parkinsonism. Provided are methods for reducing... University Of Utah Research Foundation

06/15/17 / #20170165264

Combination of creatine, an omega-3 fatty acid, and citicoline

In one aspect, the invention relates to compositions comprising at least one creatine or creatine analog, at least one omega-3 fatty acid, and citicoline analogs. Also disclosed are methods of using same, alone or in combination with other agents, to treat depression disorders and associated maladies. Also disclosed are methods... University Of Utah Research Foundation

06/15/17 / #20170166966

Autism associated genetic markers

The present disclosure relates to the identification of a subject that is affected with, or predisposed to, autism or to one or more autism spectrum disorders (ASD). The present disclosure includes methods related to the association of certain genetic markers with autism and/or ASD. More particularly, the present disclosure is... University Of Utah Research Foundation

06/08/17 / #20170157285

In situ solidifying complex coacervates and methods of making and using thereof

Described herein are fluid complex coacervates that produce solid adhesives in situ. Oppositely charged polyelectrolytes were designed to form fluid adhesive complex coacervates at ionic strengths higher than the ionic strength of the application site, but an insoluble adhesive solid or gel at the application site. When the fluid, high... University Of Utah Research Foundation

06/08/17 / #20170160252

Chemical self-doping of one-dimensional organic nanomaterials for high conductivity application in chemirsistive sensing gas or vapor

where R can be a morphology control group or -A′-D′, A and A′ can be independently a linking group, D and D′ can be independently a strong electron donor which transfers electrons to the PTCDI core sufficient to form an anionic PTCDI radical of the PTCDI core, and R1 to... University Of Utah Research Foundation

05/25/17 / #20170143199

Airway bronchoscope

A bronchoscope system is disclosed that can include a bronchoscope and a bronchoscopy instrument. The bronchoscope can include a rigid tube for insertion into an airway of a patient. The rigid tube can have a proximal end, a distal end, and a working channel extending between the proximal and distal... University Of Utah Research Foundation

05/25/17 / #20170148592

Very low power microelectromechanical devices for the internet of everything

A microelectromechanical device is disclosed and described. The microelectromechanical device can include a base having a raised support structure. The microelectromechanical device can also include a biasing electrode supported by the base. The microelectromechanical device can further include a displacement member supported by the raised support structure. The displacement member... University Of Utah Research Foundation

05/18/17 / #20170135606

System, device, and measuring net load on a lower extremity

Implementations of the present disclosure relate to apparatuses, systems, and methods for measuring net load on a lower extremity. In one embodiment a bootcast may include a body and a sole. The sole may be configured to receive at least a first force. The body may be configured to receive... University Of Utah Research Foundation

05/18/17 / #20170135607

Method and system for analyzing gait and providing real-time feedback on gait asymmetry

A method and system for analyzing gait asymmetry between left and right feet of individuals by measuring and comparing stance phase time and/or stance phase force between left and right during gait, and providing real-time sensory feedback if stance phase time/force inequality exceeds a predetermined threshold.... University Of Utah Research Foundation

05/04/17 / #20170120078

Therapeutic ultrasound breast treatment

A therapeutic ultrasound breast treatment device (101) is disclosed. The device (101) can include a receptacle (130) to receive a breast of a patient therein. The device (101) can also include an ultrasound transducer assembly disposed proximate the receptacle and oriented to direct a high intensity ultrasound transmission through an... University Of Utah Research Foundation

05/04/17 / #20170122893

Interfacial nanofibril composite for selective alkane vapor detection

A nanofiber composite sensor for detecting alkanes can include a network of contacting nanofibers having multiple contact points. Each contact point can form an interfiber interface of interdigitated alkyl chains. Alkanes can be adsorbed at the interfiber interface which results in an increased interfiber distance between first and second nanofibers... University Of Utah Research Foundation

04/27/17 / #20170112940

Modified collagen hybridizing peptides and uses thereof

Disclosed are peptide conjugates comprising an active agent, a spacer moiety, and a peptide, wherein the peptide comprises the sequence (Xaa1-Xaa2-Xaa3)n1-Xaa4-Xaa5-Xaa6-(Xaa7-Xaa8-Xaa9)n2, wherein Xaa1, Xaa2, Xaa3, Xaa4, Xaa5, Xaa6, Xaa7, Xaa8, Xaa9 is glycine, proline, a modified proline or aza-glycine, and at least one of Xaa1, Xaa2, Xaa3, Xaa4, Xaa5, Xaa6,... University Of Utah Research Foundation

04/27/17 / #20170113273

Molten salt de-oxygenation of metal powders

Methods of removing oxygen from a metal are described. In one example, a method (100) can include forming a mixture (110) including a metal, a calcium de-oxygenation agent, and a salt. The mixture can be heated (120) at a de-oxygenation temperature for a period of time to reduce an oxygen... University Of Utah Research Foundation

04/27/17 / #20170113975

Methods of sintering dense zeta-phase tantalum carbide

A method of forming a sintered ζ-phase tantalum carbide can include assembling a particulate mixture including a tantalum hydride powder and a carbon source powder. The particulate mixture can be sintered to form a tantalum carbide having at least 70 wt. % of a ζ-phase with at least about 90%... University Of Utah Research Foundation

04/20/17 / #20170105932

Intraocular drug delivery device and associated methods

Devices, systems, and methods for delivery of an active agent from the lens capsule to a posterior segment of the eye of a subject can include an intraocular active agent delivery device including an active agent dispersed within a biodegradable active agent matrix. The active agent includes dexamethasone and the... University Of Utah Research Foundation

04/20/17 / #20170108502

Biomarkers and methods for diagnosis of early stage pancreatic ductal adenocarcinoma

The present invention provides biomarker compositions and methods for the diagnosis and prognosis of PDAC. In a particular embodiment, the invention provides methods and compositions for screening, diagnosis and prognosis of early stage, asymptomatic PDAC.... University Of Utah Research Foundation

Patent Packs
04/20/17 / #20170109674

Systems and methods for managing power generation resources

An optimal operating configuration for a power system may be derived from a continuous-time model of generation and ramping constraints of power generation units available within the power system. The optimal operating configuration may be leveraged to calculate a valuation metric for power generated by the power generating units. The... University Of Utah Research Foundation

04/20/17 / #20170110678

Dual-gate chemical field effect transistor sensor

A chemical sensing field effect transistor device is disclosed. The device can include a control gate structure interfacing a control side of a semiconductor channel region, a source region, and a drain region. The control gate structure can comprise a control gate dielectric and a control gate electrode. The device... University Of Utah Research Foundation

04/13/17 / #20170100375

Compositions and methods comprising 2-(acylamino)imidazoles

The present invention presents 2-(acylamino)imidazoles with therapeutic activity, including selective activity against cancer cells, and compositions comprising them. Methods of using and preparing the 2-(acylamino)imidazoles are also presented.... University Of Utah Research Foundation

04/13/17 / #20170102725

Systems and methods for power system management

An operating configuration for a power system during a particular time period may be derived from a net load forecast for the power system during the particular time period. The operating configuration may be based on characteristics of power generation units (PGUs) available within the power system (e.g., power generators).... University Of Utah Research Foundation

04/13/17 / #20170103187

Disease therapy game technology

A video game in possession of and/or in the proximity of a patient. The patient computing system receives an indication that it is to begin a game, and executes the game using identified game parameters that are associated with the patient by a clinician as part of a disease therapy... University Of Utah Research Foundation

04/06/17 / #20170095501

Pharmaceutical compositions composed of low molecular weight sulfated hyaluronan

Described herein are pharmaceutical compositions composed of low molecular weight sulfated hyaluronan.... University Of Utah Research Foundation

03/30/17 / #20170089908

Systems and methods for label-free detection of analytes

Disclosed are methods of detecting an analyte of interest comprising introducing a sample comprising an analyte of interest to an antibody or antibody fragment; incubating the sample and antibody or antibody fragment under conditions sufficient to allow binding of the analyte of interest to the antibody or antibody fragment; and... University Of Utah Research Foundation

03/23/17 / #20170081637

Development of natural killer cells and functional natural killer cell lines

The invention relates to natural killer cells and methods for the development of immortalized natural killer cells and use of the natural killer cells. A growth and culture system is described that supports increased natural killer cell development, and provides for the establishment of continuous natural killer cell lines. Additionally,... University Of Utah Research Foundation

03/16/17 / #20170071540

High aspect ratio shadow mask and a making and using the same

A high aspect ratio shadow mask and a method of making and using the high aspect ratio shadow mask can provide multiple conductive trace pathways along high aspect ratio electrodes. The high aspect ratio shadow mask can include a substantially planar base layer and a plurality of hollow high aspect... University Of Utah Research Foundation

03/09/17 / #20170065602

Compounds with trpv4 activity, compositions and associated methods thereof

Compounds, compositions and methods useful for treating ocular diseases are provided. In particular, antagonists of TRPV4, their synthesis, pharmaceutical compositions thereof and methods of treating ocular diseases such as glaucoma, are disclosed.... University Of Utah Research Foundation

03/09/17 / #20170067015

Electrophysiological recording system and methods of using same

The disclosure provided herein provides systems, devices, and methods for analyzing cultured cells. Also disclosed herein are systems, devices, and methods for analyzing interactions between two different groups of cells. Also disclosed herein are systems and methods of producing and analyzing a three-dimensional cell culture.... University Of Utah Research Foundation

03/02/17 / #20170058047

Method of detecting ocular diseases and pathologic conditions and treatment of same

Methods of detecting and treating diseases and pathological conditions of the eye are disclosed. In particular a genetic variant of the HtrA1 gene is correlated to age related macular degeneration (AMD). In addition, biologically active agents capable of inhibiting HtrA1 activity are provided, and methods of treating diseases and pathological... University Of Utah Research Foundation

02/23/17 / #20170051075

Method of detecting ocular diseases and pathologic conditions and treatment of same

Ocular diseases affecting the macula or the vasculature of the eye affect a wide variety of individuals. In particular, Age-related macular degeneration (AMD) is the most common cause of irreversible vision loss in the developed world and has a significant genetic predisposition. Methods of analyzing one or more mutations in... University Of Utah Research Foundation

02/23/17 / #20170051280

Methods and compositions for inhibiting retinopathy of prematurity

Disclosed are vectors and compositions comprising a pol II promoter and an shRNA wherein the shRNA has a sense RNA strand and an antisense RNA strand, wherein the sense and the antisense RNA strands form an RNA duplex, and wherein the sense RNA strand comprises a nucleotide sequence identical to... University Of Utah Research Foundation

02/16/17 / #20170042662

Tissue stabilization system

Methods and systems are provided for tissue stabilization. Some aspects include a carrier member having a length, width, and thickness, wherein the length and width are each at least two times greater than the thickness; attachment members extending from the carrier member and that engage connective tissue; and stabilizing members,... University Of Utah Research Foundation

Patent Packs
02/16/17 / #20170044618

Methods and compositions involving intrinsic genes

Disclosed are compositions and methods related intrinsic gene sets and methods and compositions related to detecting and classifying cancer.... University Of Utah Research Foundation

02/09/17 / #20170035760

Galactokinase inhibitors for the treatment and prevention of associated diseases and disorders

Disclosed are inhibitors of human galactokinase of formula (1) that are useful in treating or preventing a galactokinase mediated disease or disorder, e.g., galactosemia. Also disclosed are a composition comprising a pharmaceutically acceptable carrier and at least one inhibitor of the invention, and a method of treating or preventing such... University Of Utah Research Foundation

02/02/17 / #20170027465

Systems and methods for characterizing the conductive properties of the heart

Electrophysiology mapping systems and methods that are used to determine longitudinal and transverse conduction velocities within myocardial tissue. The myocardial tissue can be contacted with at least three non-collinear electrodes. A selected electrical pacing protocol can include at least one pacing wave that is delivered to the at least three... University Of Utah Research Foundation

02/02/17 / #20170027503

Devices, systems, and methods for imaging and treating a selected tissue

A catheter for imaging and treating a selected tissue and method of use is provided. Imaging, and treatment assemblies may be co-located at a distal end of a single catheter. The imaging assembly may include at least a portion of a confocal microscope. The treatment assembly may include at least... University Of Utah Research Foundation

02/02/17 / #20170029367

Substituted aromatic sulfur compounds and methods of their use

wherein D, n, Ra, Rb, and Rc are as herein defined, along with pharmaceutical compositions and methods of using compounds of formula II for treating or reducing the risk of peritoneal carcinomatosis in a patient.... University Of Utah Research Foundation

02/02/17 / #20170030096

Elongate member reinforcement with a studded collar

An elongate member reinforcement system and associated methods are disclosed. The system can include an elongate member, a collar secured about an end portion of the elongate member, a support layer surrounding the end portion of the elongate member, and a structural filler disposed between the support layer and the... University Of Utah Research Foundation

01/26/17 / #20170020433

Fluid analysis device and associated systems and methods

A fluid analysis device including a fluid receipt chamber, a first capacitive element for measuring fluid flow into the fluid receipt chamber and a controller operatively coupled to the first capacitive element, wherein the controller is configured to measure a first capacitance of the first capacitive element.... University Of Utah Research Foundation

01/26/17 / #20170021425

Production of substantially spherical metal powders

A method for producing a substantially spherical metal powder is described. A particulate source metal includes a primary particulate and has an average starting particle size. The particulate source metal is optionally ball milled and mixed with a binder in a solvent to form a slurry. The slurry is granulated... University Of Utah Research Foundation

01/12/17 / #20170007813

Multi-site electrode arrays and methods of making the same

A multi-site electrode array (100) can include a microneedle array and a set of electrically active sites (115). The microneedle array includes a plurality of microneedles (105) supported on a base substrate (110). The set of electrically active sites (115) can be arranged at and/or near the tip of each... University Of Utah Research Foundation

01/12/17 / #20170010585

Methods and systems for generating a three-dimensional holographic mask

A system for surface patterning using a three dimensional holographic mask includes a light source configured to emit a light beam toward the holographic mask. The holographic mask can be formed as a topographical pattern on a transparent mask substrate. A semiconductor substrate can be positioned on an opposite site... University Of Utah Research Foundation

01/05/17 / #20170000894

Compositions and methods for modifying the surface of cells and methods of use

Described herein are compounds, compositions and methods for modification of the surface of a living cell with a therapeutically relevant targeting moiety. Also described herein are methods for treating disease states, such as acute myocardial ischemia or infarction, with said compositions, in a subject.... University Of Utah Research Foundation

01/05/17 / #20170001970

Substituted benzohydrazide analogs as histone demethylase inhibitors

Benzohydrazide analogs, derivatives thereof, and related compounds, which are useful as inhibitors of lysine-specific histone demethylase, including LSD1 and LSD2; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds and compositions to treat disorders associated with dysfunction of the LSD1 and/or LSD2.... University Of Utah Research Foundation








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