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University Of Utah patents (2015 archive)


Recent patent applications related to University Of Utah. University Of Utah is listed as an Agent/Assignee. Note: University Of Utah may have other listings under different names/spellings. We're not affiliated with University Of Utah, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "U" | University Of Utah-related inventors


12/31/15 / #20150374402

Surgical blade

A surgical cutting device may be made of one or more pieces and include a front edge having a plurality of incision points. The incision points may be the forwardmost points of the front edge and may be separated by a recessed portion. ... University Of Utah

12/24/15 / #20150368208

Substituted n-(3-(pyrimidin-4-yl)phenyl)acrylamide analogs as tyrosine receptor kinase btk inhibitors

In one aspect, the invention relates to substituted n-(3-(pyrimidin-4-yl)phenyl)acrylamide analogs, derivatives thereof, and related compounds, which are useful as inhibitors of the btk kinase; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds and compositions to treat disorders associated with dysfunction of the btk kinase. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.. ... University Of Utah

12/17/15 / #20150360317

Friction spot welding and friction seam welding

Systems and methods for spot welding and seam welding an upper material layer to a lower material layer using a rod. The rod can be a non-consumable rod or a consumable rod.. ... University Of Utah

12/03/15 / #20150350001

Blind phase-shift keying (psk) and quadrature amplitude modulation (qam) identification

Technology for blind phase-shift keying (psk) and quadrature amplitude modulation (qam) identification of a received radio frequency (rf) signal is disclosed. One method can include: uniform sub-sampling the received rf signal to eliminate a phase contribution from a carrier frequency of the received rf signal; and computing a likelihood function of observed phase differences of the sub-sampled received rf signal of a phase sequence for each psk modulation type. ... University Of Utah

12/03/15 / #20150343216

Modulation of ion channels

Electrical or magnetic fields oscillating at specific frequencies can modulate functions of ion channels in excitable cells. For example, an alternating current (ac) at a frequency that resonates with a particular type of ion channel can be applied to modulate conductance of the channel.. ... University Of Utah

12/03/15 / #20150343204

Pseudoporous surface of implantable materials and methods of making the same

An implantable medical device can include an electrode substrate electrically connected to at least one electrode. The device can have a pseudoporous surface across the electrode substrate and electrode. ... University Of Utah

11/26/15 / #20150338665

Ultra-high efficiency color mixing and color separation

Methods and apparatus for combining or separating spectral components by means of a polychromat. A polychromat is employed to combine a plurality of beams, each derived from a separate source, into a single output beam, thereby providing for definition of one or more of the intensity, color, color uniformity, divergence angle, degree of collimation, polarization, focus, or beam waist of the output beam. ... University Of Utah

11/26/15 / #20150338408

Single step calibration curve through sample convection

This disclosure relates to methods and apparatuses for simultaneous measurement of multiple analytes in samples. This disclosure relates to methods and apparatuses for determining the concentration of one or more analytes in a fluid sample without use of a calibrant.. ... University Of Utah

11/12/15 / #20150320675

Modified release osmotic pump for ph-responsive drug delivery

In one aspect, the invention relates to controlled-release devices and methods of using same, alone or in combination with other agents, to deliver pharmaceutical agents, and more particularly to deliver birth control agent, fertility agents, hormone replacement agents, cervical ripening agents, agents to prevent a sexually transmitted disease, agents to treat a sexually transmitted disease, biologics, agents to treat a mucosal infection, agents to treat uterine fibroids, agents to treat reproductive cancers, agents to treat nausea gravidarum, and/or agents to treat endometriosis. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.. ... University Of Utah

10/29/15 / #20150307455

Heterocyclic compounds

Described herein are methods for synthesizing heterocyclic, 8-membered ring structures. The methods may allow for preparation of highly substituted 8-membered rings. ... University Of Utah

10/29/15 / #20150305643

Neural interface

Technology for a neural interface is described. The neural interface can include an intracranial electrode grid operable to detect neural activity. ... University Of Utah

10/22/15 / #20150299797

Compositions and methods relating to blood-based biomarkers of breast cancer

The present invention relates generally to the field of breast cancer. More specifically, the invention concerns methods and compositions useful for diagnosing treating breast cancer.. ... University Of Utah

10/22/15 / #20150299633

Periodic symmetry defined bioreactor

A bioreactor can include a plurality of unit cells. Each unit cell can include a floor configured to support a volume of liquid, the floor being symmetric across at least one axis of symmetry, and an injection port oriented at a center point of at least one axis of symmetry and configured to inject a fluid into the volume of liquid. ... University Of Utah

10/01/15 / #20150275307

Compositions and methods for detecting sessile serrated adenomas/polyps

Provided are methods of predicting the likelihood that a colorectal polyp in a subject will develop into colorectal cancer. Further provided are methods of increasing the likelihood of detecting colorectal cancer at an early stage, the methods including predicting the likelihood that a colorectal polyp in a subject will develop into colorectal cancer, and when there is an increased likelihood that the colorectal polyp will develop into colorectal cancer, the frequency of colonoscopies administered to the subject are increased. ... University Of Utah

10/01/15 / #20150274639

Methods of use for compositions comprising a biocidal polyamine

Compounds, compositions, and methods comprising a polyamine compound are described, which may be used to kill, disperse, treat, reduce biofilms, and/or inhibit or substantially prevent biofilm formation. In certain aspects, the present invention relates to compounds, compositions, and methods comprising polyamine compounds that have antimicrobial or dispersing activity against a variety of bacterial strains capable of forming biofilms.. ... University Of Utah

10/01/15 / #20150272702

Radiopaque marking implement

This disclosure provides marking implements for making radiopaque markings, and methods of using the same.. . ... University Of Utah

09/17/15 / #20150259741

Methods and compositions for the diagnosis of multiple sclerosis

Disclosed herein are methods and compositions for diagnosing multiple sclerosis (“ms”) in a subject or the risk of ms in a subject. More particularly, methods and compositions for the use of genetic markers for diagnosing ms in subject or the risk of ms in a subject.. ... University Of Utah

09/17/15 / #20150259738

Calibrators for use in high-resolution melt analysis and related methods

Calibrators for use in high-resolution melt analysis and related methods are disclosed and described. In one embodiment a polynucleotide thermal melt calibrator having a stem-loop configuration may include: a first stem region having a first nucleotide sequence; a second stem region having a second nucleotide sequence; a loop region joining the first stem region and the second stem region; and a hybridization indicator associated with at least one of the first stem region, the second stem region, or the loop region.. ... University Of Utah

09/10/15 / #20150252048

Substituted n-(3-pyrimidin-4-yl)phenyl)acrylamide analogs as tyrosine receptor kinase btk inhibitors

In one aspect, the invention relates to substituted n-(3-(pyrimidin-4-yl)phenyl)acrylamide analogs, derivatives thereof, and related compounds, which are useful as inhibitors of the btk kinase; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds and compositions to treat disorders associated with dysfunction of the btk kinase. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.. ... University Of Utah

09/03/15 / #20150249889

Digital signal processor for audio extensions and correction of nonlinear distortions in loudspeakers

Digital filters for processing an input audio signal for extending the audio capabilities and reducing distortion of a loudspeaker. Such extension may include a general sound pressure level (spl) extension or a more targeted low frequency (lf) extension. ... University Of Utah

09/03/15 / #20150247209

Monitoring temperature with fluorescence

Systems, methods, and kits are provided wherein a temperature-sensitive reagent that emits a luminescent signal is used to adjust the identification of the temperature of a sample or to control thermocycling. In various illustrative embodiments, the sample is a pcr mixture.. ... University Of Utah

08/27/15 / #20150238781

Image-guided tissue ablation

A method of treating hypertension in a mammal is described, including: by focused sound energy, heating at least one nerve at a surface of a renal artery in a mammal; during the heating and by magnetic resonance imaging, repeatedly determining thermal levels in each of first and second volumetric zones of a region that includes at least a portion of the surface, the second zone being adjacent to the first zone; after determining that an indicium of a thermal level in the first zone exceeds a first threshold, and upon determining that an indicium of a thermal level in the second zone exceeds a second threshold, ceasing the heating of the at least one nerve for at least three months; and as a result of the heating, lowering a blood pressure in the mammal.. . ... University Of Utah

08/27/15 / #20150238415

Intravaginal devices for controlled delivery of lubricants

The present technology provides intravaginal devices designed to deliver lubricants to the vagina for a sustained period of time. The intravaginal devices include a first segment comprising an outer surface and a lumen containing a lubricant, wherein the first segment is configured to deliver the contents of the lumen to the outer surface, and the first segment comprises a polymer selected from the group consisting of a hydrophilic, semi-permeable elastomer and a hydrophobic elastomer. ... University Of Utah

08/20/15 / #20150236643

Systems and methods for fault detection

A fault detection module acquires spread spectrum time domain reflectometry (sstdr) data pertaining to an electrical system, such as a photovoltaic string. A fault may be detected by use of difference data, calculated by comparing the sstdr autocorrelation data to baseline sstdr autocorrelation data previously acquired from the electrical system. ... University Of Utah

08/20/15 / #20150232945

Identification of novel pathways for drug development for lung disease

The invention provides the identification of oncogenic pathways activated in cytologically normal airway cells of individuals having or at risk of having lung disease, as well as specific gene expression patterns (biomarkers) associated with pathway activation. These biomarkers and pathways may provide prognostic and/or diagnostic indicators in lung disease, e.g., lung cancer. ... University Of Utah

08/13/15 / #20150225466

Compositions and methods for peptide expression and purification using a type iii secretion system

Disclosed are compositions and methods for expressing and purifying a peptide of interest using a flagellar type iii secretion system. Disclosed are nucleic acid sequences that contain a flgm nucleic acid sequence, a cleavage site, and a nucleic acid sequence of interest. ... University Of Utah

08/06/15 / #20150222166

Flexible devices, systems, and methods for harvesting energy

Embodiments of the present invention relate to systems, methods, and apparatus for harvesting energy by transforming mechanical energy into electrical energy. Particularly, the energy can be harvested by converting mechanical energy produced during operations or movements of a body (e.g., a vehicle, a person, a machine, etc.) that generate alternating or periodic force, which can be received by the energy harvesting device.. ... University Of Utah

07/30/15 / #20150211065

Methods of predicting the development of amd based on chromosome 1 and chromosome 10

Disclosed herein are methods and compositions for the diagnosis and treatment of amd based on snps, haplotypes, and diplotypes on chromosome 1 and chromosome 10.. . ... University Of Utah

07/30/15 / #20150209385

Use of alkylated semi-synthetic glycosaminoglycosan ethers for the treatment of inflammation

Described herein are methods for treating inflammation in a subject comprising administering to the subject an effective amount of a modified hyaluronan or a pharmaceutically acceptable salt or ester thereof, wherein said hyaluronan or its pharmaceutically acceptable salt or ester comprises at least one sulfate group and the primary c-6 hydroxyl proton of at least one n-acetyl-glucosamine residue is substituted with a c1-c10 unsubstituted alkyl group or fluoroalkyl group.. . ... University Of Utah

07/30/15 / #20150209353

Application of 5-ht6 receptor antagonists for the alleviation of cognitive deficits of down syndrome

Methods for treating down syndrome and improving cognitive function of a patient with an intellectual disability are disclosed. 5-hydroxytryptamine sub-receptor six (5-ht6) receptor antagonists are provided for improving the cognition of a down syndrome patient.. ... University Of Utah

07/23/15 / #20150204836

Soluble metal sensor compounds and methods for making and using the same

Described herein are the preparation and use of metal sensor compounds in detecting metals that are toxic to humans or to the environment. In one aspect, the metal sensor compounds comprise a polycyclic aryl group (pac), wherein at least one solubilizing group and at least one metal binding ligand are covalently bonded to (pac).. ... University Of Utah

07/23/15 / #20150203554

Methods and compositions related to improving properties of pharmacological agents targeting nervous system

Disclosed are compositions and methods related to improving pharmacological properties of bioactive compounds targeting nervous system.. . ... University Of Utah

07/09/15 / #20150194473

Device comprising deuterated organic interlayer

The present invention relates to devices that can be manipulated or controlled with a magnetic field, such as a spin-valve device, an organic light-emitting device, a compass, or a magnetometer. The devices of the invention comprise an organic interlayer comprising a deuterated organic material.. ... University Of Utah

07/02/15 / #20150185200

Detection of nucleic acid lesions and adducts using nanopores

Methods, systems, and compounds for detecting modified nucleic acid bases are disclosed and described. The methods provide for detecting a nucleic acid lesion and can include directing a nucleic acid adduct into a channel, wherein the nucleic acid adduct includes a nucleic acid having a lesion and a current modulating compound coupled to the nucleic acid at the lesion (110), and measuring a change in current through the channel in response to the current modulating compound to detect the lesion (112). ... University Of Utah

07/02/15 / #20150182601

Compositions and methods for selectively producing sirna

The disclosure provided herein provides compositions and methods for producing sirna. Also disclosed are compositions and methods for modulating the production of sirna. ... University Of Utah

07/02/15 / #20150182356

Modular prosthetic abutment system

An abutment system for operatively coupling an implant stem to an exo-prosthesis. The abutment system includes a plurality of interlocking sleeve elements that are operatively coupled to an implant stem positioned within a prepared site of a selected bone. ... University Of Utah

06/25/15 / #20150173764

Tissue fixation

Methods and systems are provided for tissue stabilization. Some aspects include a carrier member having a length, width, and thickness, wherein the length and width are each at least two times greater than the thickness; attachment members extending from the carrier member and that engage connective tissue; and stabilizing members, each of which can couple a respective attachment member to the carrier member and is substantially positionally fixed relative to the carrier member.. ... University Of Utah

06/25/15 / #20150173692

Computed tomography devices, systems, and methods

Computed tomography devices, systems, and associated methods are disclosed. The device can include a radiation source coupleable to a rotating gantry to emit radiation from an adjustable focal spot toward a volume of interest. ... University Of Utah

06/18/15 / #20150169835

Faint and fall assessment

A computer-implemented method of assessing a patient is provided. In some embodiments, the method includes displaying a first set of queries concerning a patient and receiving a response to at least one of the queries, the response indicating that the patient has recently experienced at least one of (i) losing consciousness, (ii) falling, and (iii) being uncertain about whether the patient has lost consciousness. ... University Of Utah

06/18/15 / #20150168616

Nanoparticle light filtering method and apparatus

Implementations of the present invention relate to apparatuses, systems, and methods for blocking, attenuating, or filtering neuroactive wavelengths of the visible light spectrum and reducing or preventing the symptoms affiliated with exposure to those wavelengths. Nanoparticles of a predetermined composition, size, and structure are dispersed in a host medium to create an optical notch filter, thereby attenuating only a narrow range of the visible spectrum.. ... University Of Utah

06/11/15 / #20150162557

Spin-polarized light-emitting diodes based on organic bipolar spin valves

Spin-polarized organic light-emitting diodes are provided. Such spin-polarized organic light-emitting diodes incorporate ferromagnetic electrodes and show considerable spin-valve magneto-electroluminescence and magneto-conductivity responses, with voltage and temperature dependencies that originate from the bipolar spin-polarized space charge limited current.. ... University Of Utah

06/11/15 / #20150162158

Micro-plasma field effect transistors

In some aspects, a micro-plasma device comprises a plasma gas enclosure containing at least one plasma gas, and a plurality of electrodes interfaced with the plasma gas enclosure. In other aspects, a micro-plasma circuitry apparatus comprises a first layer having a cavity formed therein and a second layer having a circuit formed therein. ... University Of Utah

06/11/15 / #20150157413

Integrated surgical cutting system

Integrated surgical systems and methods for using same are provided that can receive scanned images and produce a three dimensional model from the images. Based at least in part on the three dimensional model, a processor generates code defining an optimized tool path, which is sent to a surgical machining system that can machine the desired portion of the patient. ... University Of Utah

06/04/15 / #20150152382

Pure populations of astrocyte restricted precursor cells and methods for isolation and use thereof

An isolated, pure homogeneous population of mammalian astrocyte restricted precursor cells which is cd44 immunoreactive and which generate astrocytes but not oligodendrocytes is provided. Methods for identifying, isolating and using these mammalian astrocyte restricted precursor cells are also provided.. ... University Of Utah

06/04/15 / #20150152165

Matrix metalloproteinase cleavable protein polymers for cancer gene therapy

A delivery system that includes a recombinantly synthesized protein polymer with protease cleavage sites such as matrix metalloproteinase responsive sequences engineered within the protein polymer. The system may be used to treat cancer, wounds, or pathological conditions in other tissues that express excess protease relative to healthy tissue.. ... University Of Utah

06/04/15 / #20150151028

Tropoelastin for promoting endothelial cell adhesion or migration

The invention provides methods, compositions, and devices for promoting adhesion or migration of endothelial cell.. . ... University Of Utah

06/04/15 / #20150150864

Substituted (e)-n'-(1-phenylethylidene)benzohydrazide analogs as histone demethylase inhibitors

In one aspect, the invention relates to substituted (e)-n′-(1-phenylethylidene)benzohydrazide analogs, derivatives thereof, and related compounds, which are useful as inhibitors of lysine-specific histone demethylase, including lsd1; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds and compositions to treat disorders associated with dysfunction of the lsd1. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.. ... University Of Utah

05/28/15 / #20150148910

Prosthetic joint

A prosthetic joint (100) comprises a first component (110) having a first interface portion (111). The prosthetic joint (100) further comprises a second component (120) having a second interface portion (121) with a textured surface (122) to interface with the first interface portion (111) and form a skeletal joint. ... University Of Utah

05/28/15 / #20150148869

Charge steering high density electrode array

Technology for deep brain stimulating including devices, systems, computer circuitry, and associated methods is provided. A deep brain stimulating device (100) can include a semiconductor substrate, an array of electrodes (140) coupled to the semiconductor substrate, and circuitry operable to control the array of electrodes (140). ... University Of Utah

05/28/15 / #20150148251

Autism associated genetic markers

The present disclosure relates to the identification of a subject that is affected with, or predisposed to, autism or to one or more autism spectrum disorders (asd). The present disclosure includes methods related to the association of certain genetic markers with autism and/or asd. ... University Of Utah

05/28/15 / #20150145986

Annular thermoacoustic energy converter

A thermoacoustic energy converter for converting heat energy to electricity includes an annular resonator with a regenerator disposed therein. An electro-mechanical transducer is coupled to the annular resonator and in fluid communication with the working fluid. ... University Of Utah

05/28/15 / #20150145470

Micro-energy harvesting device for space-limited applications

Implementations of the present invention relate to apparatuses, systems, and methods for harvesting mechanical energy from micro-energy sources and converting that energy into electrical energy. Such mechanical energy sources may be from common motions or processes such as the movement of cars or people. ... University Of Utah

05/21/15 / #20150138661

Nanoparticle light filtering method and apparatus

Implementations of the present invention relate to apparatuses, systems, and methods for blocking, attenuating, or filtering neuroactive wavelengths of the visible light spectrum and reducing or preventing the symptoms affiliated with exposure to those wavelengths. Nanoparticles of a predetermined composition, size, and structure are dispersed in a host medium to create an optical notch filter, thereby attenuating only a narrow range of the visible spectrum.. ... University Of Utah

05/07/15 / #20150126604

Branched chain amino acids: formulations and methods of treatment

The present disclosure includes a formulation of branched chain amino acids and arginine for treatment of diseases for which the pathological mechanism includes autophagy. The formulation includes defined ratios of the branched chain amino acids isoleucine, leucine, and valine along with arginine. ... University Of Utah

04/30/15 / #20150119708

Devices and systems for fluorescence imaging of tissue

A system and method for fluorescence imaging of tissue in vivo and in situ, e.g., for minimally invasive diagnosis of patients. A fluorescent imaging system is provided that has a dye carrier coupled to the distal end of a probe containing a fiber optics bundle, which allows for the introduction of at least one fluorescent dye therein the dye carrier into a portion of the tissue of interest of a subject or patient when the dye carrier is selectively brought into contact with the portion of the tissue of interest. ... University Of Utah

04/30/15 / #20150118760

Fluorescent sensing of vapors using tubular nanofibril materials

A fluorescence-based sensor can comprise a nanofiber mass of nanofibers having tubular morphology and a fluorescence detector, where fluorescence of the nanofibers decreases upon contact with a nitro-containing compound. The nanofibers can comprise carbazole-cornered, arylene-ethynylene tetracyclic macromolecules of formula i: where r1-r4 are alkyl-containing groups. ... University Of Utah

04/30/15 / #20150118758

Compounds, sensors, methods, and systems for detecting gamma radiation

Methods, compositions, and systems for detecting gamma radiation is disclosed and described. A compound for detecting gamma radiation can comprise a conjugated imidazole having the following structure: [formula i] where at least one of r1, r2, and r3 are conjugated organic groups. ... University Of Utah

04/30/15 / #20150118715

Extreme pcr

Methods, devices, and kits are provided for performing pcr in <20 seconds cycle, with improved efficiency and yield.. . ... University Of Utah

04/09/15 / #20150099965

System for high resolution fast acquisition magnetic resonance imaging using a catheter-mounted coil

A catheter-mounted, expandable or set in position, coil for magnetic resonance imaging. The coil having a catheter sheath including an elongated tube with a central axis, the catheter sheath having an opening at an end thereof; an expandable coil including a conductive material connected to an expansion mechanism which, when deployed, maintains the expandable receive coil shape; and a cable running through the catheter sheath, the cable being electrically connected to the coil inductive loop.. ... University Of Utah

04/09/15 / #20150099790

Compositions and methods for modulating mitochondrial pyruvate carrier activity

Disclosed herein are methods and compositions for the diagnosis and treatment of conditions associated with aberrant pyruvate metabolism, and symptoms thereof, in a subject. Disclosed herein are methods of detecting an aberrant pyruvate metabolism-associated condition, and symptoms thereof, in a subject, by the expression level of mpc1 or mpc2. ... University Of Utah

03/26/15 / #20150087692

Morpholino-mediated increase in soluble flt-1 expression results in decreased ocular and tumor neovascularization

Methods of inhibiting lymphangiogenesis and/or angiogenesis in a subject are provided. In one aspect, for example, a method of inhibiting angiogenesis in a subject can include binding an antisense morpholino to an mrna splicing site of vegfr1 selected from exon13_intron13 junction, intron13_exon14 junction, or a combination thereof. ... University Of Utah

03/19/15 / #20150078506

Practical model based ct construction

A method for a practical model based computed tomography construction may include assuming that a filtered back projection reconstruction of a computed tomography image is available and acquiring a deviate of a multivariate random variable computed tomography data set. A filtered back projection reconstruction of the image may be estimated, and the filtered back projection reconstruction may be identified as a deviate of a multivariate random variable. ... University Of Utah

03/19/15 / #20150077644

Display backlight

A display backlight can include a light source and a parabolic waveguide. The parabolic waveguide can have a light inlet to receive the light from the light source, a parabolic reflective surface adapted to change a direction of the light emitted from the light source by a predetermined angle, and a light outlet configured to emit the light at the predetermined angle.. ... University Of Utah

03/19/15 / #20150075987

Devices and methods for separating nanoparticles

A device and related method for separating nanometer particles is disclosed and described. The device can include a microfluidic system including a sample input port, a fluid flow channel, and a sample output port, in which the fluid flow channel is defined by a pair of electrode walls and an insulator. ... University Of Utah

03/19/15 / #20150075099

Elongate member reinforcement

An elongate member reinforcement system and associated methods is disclosed. The system can include an elongate member, a structure associated with an end of the elongate member, a support member coupled to the structure and laterally offset from the elongate member extending about an end portion of the elongate member, a support layer surrounding the end portion of the elongate member such that at least a portion of the support member is between the support layer and the elongate member, and a structural filler disposed between the support layer and the elongate member. ... University Of Utah

03/12/15 / #20150072352

Small molecule-dependent split aptamer ligation

Methods, assays, and products for the detection of small molecules are provided. In one aspect, for example, a method of detecting a small molecule in a sample can include reacting together a first half of a dna split aptamer having a first reactive group coupled thereto, a second half of a dna split aptamer having a second reactive group coupled thereto, where the dna split aptamer is selective for the small molecule, and a sample containing the small molecule. ... University Of Utah

03/12/15 / #20150072021

Methods and kits for predicting outcome and methods and kits for treating breast cancer with radiation therapy

The application describes methods and kits for screening subjects with breast cancer to determine if the breast cancer will be responsive to a post-mastectomy breast cancer therapy including radiation. The application further describes methods and kits for treating subjects with post-mastectomy breast cancer by screening them for the likelihood of the effectiveness of treating the cancer with a therapy including radiation and administering the therapy in subjects when it is found that radiation is likely to be effective.. ... University Of Utah

03/05/15 / #20150066064

Tissue stabilization system

Methods and systems are provided for tissue stabilization. Some aspects include a carrier member having a length, width, and thickness, wherein the length and width are each at least two times greater than the thickness; attachment members extending from the carrier member and that engage connective tissue; and stabilizing members, each of which can couple a respective attachment member to the carrier member and is substantially positionally fixed relative to the carrier member.. ... University Of Utah

03/05/15 / #20150065495

Substituted- 1h-benzo[d]imidazole series compounds as lysine-specific demethylase 1 (lsd1) inhibitors

The present invention provides compounds which are useful as inhibitors of lysine-specific demethylase 1 (“lsd1”). The present invention also relates to pharmaceutical compositions containing these compounds. ... University Of Utah

03/05/15 / #20150061832

Directly observed thearpy using mobile technology

The present disclosure provides systems and methods for performing directly observed therapy, and particularly, mobile directly observed therapy.. . ... University Of Utah

02/26/15 / #20150057517

Sample capture device and systems and methods of using same

Disclosed are devices, compositions, and methods for diagnosing eosinophilic esophagitis in a subject. Also disclosed are methods for monitoring the course of eosinophilic esophagitis in a subject before, during, and after treatment.. ... University Of Utah

02/26/15 / #20150057339

High molecular weight arginine-grafted bioreducible polymers

The polymeric carrier for delivering nucleic acid material to a cell is provided herein. The polymeric carrier can include a dendrimer group having 2 to 8 termini, each of the termini having an arginine-grafted bioreducible polymer attached thereto. ... University Of Utah

02/26/15 / #20150056587

Method and system for automating the scoring of task information

A method and system for scoring task information. Through the use of an electronic time management device, such as a cell phone or other portable digital computer based device programmed to support this method, a user enters a description of a task and when the task should be completed. ... University Of Utah

02/05/15 / #20150039000

System for tissue fixation to bone

Methods and systems are provided for fixating connective tissue to bone. Some aspects include a carrier member having a length, width, and thickness, wherein the length and width are each at least two times greater than the thickness; attachment members extending from the carrier member and that engage connective tissue of an animal; and a bone engaging member extending from the carrier member and configured to attach to a bone of the animal. ... University Of Utah

02/05/15 / #20150038705

Methods of use comprising a biocidal polyamine

Compounds, compositions, and methods comprising a polyamine compound are described, which may be used to kill, disperse, treat, reduce biofilms, and/or inhibit or substantially prevent biofilm formation. In certain aspects, the present invention relates to compounds, compositions, and methods comprising polyamine compounds that have antimicrobial or dispersing activity against a variety of bacterial strains capable of forming biofilms.. ... University Of Utah

02/05/15 / #20150038512

Compositions and methods comprising a biocidal polyamine

Compounds, compositions, and methods comprising a polyamine compound are described, which may be used to kill, disperse, treat, or reduce biofilms, or to inhibit or substantially prevent biofilm formation. In certain aspects, the present invention relates to compounds, compositions, and methods comprising polyamine compounds that have antimicrobial or dispersing activity against a variety of bacterial strains capable of forming biofilms.. ... University Of Utah

02/05/15 / #20150036117

Maskless nanoimprint lithography

A method for creating a nanoimprint lithography template includes exposing (600) a mass transport layer of material adjacent to a support substrate to electromagnetic radiation in a predetermined pattern to form a nanoimprint lithography template in the mass transport layer.. . ... University Of Utah

01/29/15 / #20150032402

Extraction of spectral information

A spectral distribution of incident light can be determined to increase collected spectral information. The spectral distribution of the incident light can be represented as a sum of spectral components after the incident light passes through a spectrum selective element. ... University Of Utah

01/29/15 / #20150030050

Ultrasonic temperature measurement device

An ultrasonic thermometer for measuring a temperature profile along a measurement axis of a structure, comprising a continuous measurement pathway of a structure (310) having a longitudinal measurement axis and proximal (202) and distal ends (204), and at least two backscatterers (332) formed therein transverse to the longitudinal axis and separated by a predetermined separation distance.. . ... University Of Utah

01/22/15 / #20150025114

Substituted 1h-indazol-1-ol analogs as inhibitors of beta catenin/tcf protein-protein interactions

In one aspect, the invention relates to substituted 1h-benzo[d][1,2,3]triazol-1-ol analgoues, derivatives thereof, and related compound; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating disorders, e.g. Various tumors and cancers, associated with β-catenin/tcf protein-protein interaction dysfunction using the compounds and compositions. ... University Of Utah

01/22/15 / #20150025013

Compositions and methods of use for (pro)renin receptor

Disclosed are methods of treating kidney disease, infectious or inflammatory diseases, acute kidney injury and hypertension by administering a (pro)renin receptor (prr) antagonist. In some instances the prr antagonist is a polypeptide. ... University Of Utah

01/22/15 / #20150024998

Isolation, identification, and uses of antifungal compounds

In one aspect, the invention relates to isolated compounds useful as antifungal agents, for example, compounds having a structure represented by a formula: wherein r1 is hydrogen or hydroxyl; wherein r2 is hydrogen, a-xylose or β-xylose; and wherein r3 and r4 are each hydrogen or together oxygen, or a pharmaceutically acceptable salt thereof; methods of isolating and purifying same; pharmaceutical compositions comprising same; agricultural compositions comprising same; and methods of treating and/or preventing fungal infections using same. In one aspect, r2 is not hydrogen or β-xylose when r1 is hydroxyl and r3 and r4 are together oxygen. ... University Of Utah

01/22/15 / #20150024399

Molecular diagnosis and typing of lung cancer variants

Compositions and methods useful in determining the major morphological types of lung cancer are provided. The methods include detecting expression of at least one gene or biomarker in a sample. ... University Of Utah

01/15/15 / #20150018349

Substituted n-(3-(pyrimidin-4-yl)phenyl)acrylamide analogs as tyrosine receptor kinase btk inhibitors

In one aspect, the invention relates to substituted n-(3-(pyrimidin-4-yl)phenyl)acrylamide analogs, derivatives thereof, and related compounds, which are useful as inhibitors of the btk kinase; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds and compositions to treat disorders associated with dysfunction of the btk kinase. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.. ... University Of Utah

01/15/15 / #20150017675

Assay for determining relative redox changes in living cells and associated devices, systems, and methods

The present disclosure provides conjugates, systems, devices, and methods for detecting cellular redox state. In one aspect, for example, a conjugate for detecting cellular redox state can include a first segment including a cell penetrating peptide conjugated to a first detection molecule, and a second segment including a cargo peptide conjugated to a second detection molecule, wherein the first segment and the second segment are coupled together by a redox-sensitive linkage, and wherein the first detection molecule and the second detection molecule have properties that allow linked proximity detection. ... University Of Utah

01/08/15 / #20150011867

Retrospectively correlated turbo spin echo imaging

Systems and methods which generate a sequence of images using turbo spin echo magnetic resonance imaging which are retrospectively correlated with periodic motion occurring within a subject being imaged are described. In one embodiment, k-space measurements (or the measurements from which images are formed) are captured during, and correlated with, different phases in a cardiac cycle of the subject. ... University Of Utah








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