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University Of Washington patents


Recent patent applications related to University Of Washington. University Of Washington is listed as an Agent/Assignee. Note: University Of Washington may have other listings under different names/spellings. We're not affiliated with University Of Washington, we're just tracking patents.

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 new patent  Thermally conductive graft

The present disclosure provides thermally conductive grafts and methods of passively cooling a hyperthermic region and preventing epilepsy, neural inflammation, and other neurological abnormalities using a thermally conductive graft including a thermally conductive matrix disposed between two opposed surfaces.... University Of Washington

Prolonged anti-diabetic effect of fibroblast growth factor 1 (fgf1)

Disclosed are compositions and methods for inducing sustained diabetes remission by single administration of FGF1 to the brain. The composition and methods described herein result in basal glucose clearance by using a dosage of FGF1 that is lower than that needed for systemic efficacy and is devoid of the risk... University Of Washington

System and immersion flow cytometry

An immersion cytometry system (200, 250) having a primary focusing optic immersed in a fluid stream (209) containing suspended particles (212). The system includes a light source (202) configured to illuminate a sensing region in the fluid stream that includes a focus of the primary optic. Light scattered and/or fluoresced... University Of Washington

Materials and methods for detecting androgen receptor splice variants and uses thereof

The present disclosure relates to materials and methods for evaluating prostate cancer using binding entities (such as antibodies) that bind to the N-terminus and the C-Terminus of androgen receptor. Prostate samples are histochemically labeled for the N-terminus and the C-Terminus of androgen receptor, and a ratio between the binding of... University Of Washington

Method for solid freeform fabrication

The present invention provides methods, processes, and systems for the manufacture of three-dimensional articles made of polymers using 3D printing. A layer of prepolymer is deposited on a build plate to form a powder bed. The deposited powder bed is heated to about 50° C. to about 170° C. Then,... University Of Washington

Devices and methods for metatarsophalangeal arthroplasty procedures

The present technology relates generally to devices and methods for arthroplasty procedures. In some embodiments, for example, a device is disclosed for use during an arthroplasty procedure of a joint of a patient, the joint extending between a first joint end of a first bone and an abutting second joint... University Of Washington

Neutralizing antibodies to hiv-1 and their use

Monoclonal neutralizing antibodies are disclosed that specifically bind to the CD4 binding site of HIV-1 gp120. Monoclonal neutralizing antibodies also are disclosed that specifically bind to HIV-1 gp41. The identification of these antibodies, and the use of these antibodies are also disclosed. Methods are also provided for enhancing the binding... University Of Washington

Hormone degradable crispr-based transcription factors

Synthetic signal transduction systems are provided. The synthetic signal transduction system may be a hormone degradable CRISPR-based transcription factor including a nuclease null Cas9 protein, a nuclear localization signal, a phytohormone degron, and a transcriptional regulation domain. Methods of generating non-naturally occurring plants are also provided. The methods may include... University Of Washington

Active control of vortices for skin friction reduction

Systems and method for active control of stationary vortices for aerodynamic structures are disclosed herein. In one embodiment, a method for active control of vortices over a solid surface includes: generating vortices proximate to the solid surface; sensing locations of vortices by printed skin sensors; and maintaining the vortices in... University Of Washington

Methods for treating and preventing cardiomyopathy

Methods for treating patients having a cardiomyopathy are provided. Additionally, methods for prophylactically treating patients at risk of developing a cardiomyopathy are provided. Methods for treating patients having, or at risk of developing, a cardiomyopathy may comprise administering a fusion protein including a tafazzin peptide and a cellular permeability peptide... University Of Washington

Muscle-specific crispr/cas9 editing of genes

Pharmaceutical compositions including a muscle-specific nuclease cassette, one or more guide RNA cassettes, and a delivery system for delivery of the muscle-specific nuclease cassette and the one or more gRNA cassettes are provided. The pharmaceutical composition may also include a mutation-corrected DNA template including a modification to be made in... University Of Washington

Biosensors engineered from conditionally stable ligand-binding domains

Disclosed is a biosensor engineered to conditionally respond to the presence of specific small molecules, the biosensors including conditionally stable ligand-binding domains (LBDs) which respond to the presence of specific small molecules, wherein readout of binding is provided by reporter genes or transcription factors (TFs) fused to the LBDs.... University Of Washington

Systems and methods of identifying motion of a subject

Systems and methods of identifying medical disorders in one or more subjects are disclosed herein. In one embodiment, sound is transmitted toward a subject and at least a portion of the sound reflected by the subject and is acquired as echo data. The acquired echo data is used to generate... University Of Washington

Computer-assisted osteocutaneous free flap reconstruction

Example methods and systems to facilitate osteocutaneous free flap reconstructions are provided. One example method involves causing a surgical navigation system to display a representation of a patient undergoing surgery; receiving input data representing one or more osteotomies made during the surgery to form a defect within the patient; determining... University Of Washington

Hla-dr binding peptides and their uses

The present invention provides HLA-DR (MHC class II) binding peptides derived from the ovarian/breast cancer associated antigens, Human Epidermal Growth Factor Receptor 2 (HER-2/neu), Carcinoembryonic Antigen (CEA), Insulin Growth Factor Binding Protein 2 (IGFBP-2), and Cyclin D1. The immunogenic peptides can be used in cancer vaccines.... University Of Washington

Nanoparticles for photovoltaic and led devices and methods of making the same

The present disclosure relates to a composition that includes a particle and a surface species, where the particle has a characteristic length between greater than zero nm and 100 nm inclusively, and the surface species is associated with a surface of the particle such that the particle maintains a crystalline... University Of Washington

Additive manufacturing using stimuli-responsive high-performance polymers

The present invention provides high performance polymer (HPP) compositions, methods, processes, and systems for the manufacture of three-dimensional articles made of polymers using molding or 3D printing. The HPP compositions comprise a first HPP dissolved in a solvent and a second HPP present as a solid having particular particle size.... University Of Washington

3d printable hydrogel materials

Hydrogel compositions including a polymer uniformly embedded with a loading agent are provided. Also provided are methods for extrusion printing hydrogel compositions to provide extruded hydrogel compositions, which can be crosslinked to provide crosslinked hydrogel structures. Also provided are methods for using crosslinked hydrogel structures in chemical processes.... University Of Washington

Systems, devices, and methods for separating, concentrating, and/or differentiating between cells from a cell sample

Embodiments are generally related to differentiating and/or separating portions of a sample that are of interest from the remainder of the sample. Embodiments may be directed towards separating cells of interest from a cell sample. In some embodiments, acoustic impedances of the cells of interest may be modified. For example,... University Of Washington

Ambient backscatter tranceivers, apparatuses, systems, and methods for communicating using backscatter of ambient rf signals

Apparatuses, systems, ambient backscatter transceivers, and methods for modulating a backscatter of an ambient RF signal are described. An example system may include an ambient backscatter transceiver comprising an antenna that is configured to receive a backscattered ambient radio frequency (RF) signal. The ambient backscatter transceiver is configured to demodulate... University Of Washington

High affinity vitamin d3 binding proteins

The present disclosure provides isolated polypeptides with vitamin D3 binding activity and methods for their use as detection agents. In another aspect, the invention provides recombinant expression vector comprising an isolated nucleic acid of the invention operably linked to a control sequence. In another aspect, the invention provides recombinant host... University Of Washington

Filter-free devices and systems for measuring fluorescence of a microfluidic assay and associated methods of use

The present technology relates generally to devices, systems, and methods for detecting an analyte from a microfluidic assay. In some embodiments, a method for detecting the analyte includes binding an analyte and a plurality of quantum dots to a detection region of a porous membrane of a microfluidic device. The... University Of Washington

Methods and defibrillators utilizing hidden markov models to analyze ecg and/or impedance signals

Examples described herein include defibrillators or other medical equipment that may employ hidden Markov models to classify cardiac rhythms in ECG signals. Hidden Markov models may additionally or instead be used to determine presence of a chest compression from the thoracic impedance signal. Classification of cardiac rhythms may be used... University Of Washington

Branched discrete peg constructs

Disclosed are general and “substantially pure” branched discrete polyethylene glycol constructs useful in attaching to a variety of biologically active groups, for example, preferential locators, as well as biologics like enzymes, for use in diagnostics, e.g. imaging, therapeutics, theranostics, and moieties specific for other applications. In its simplest intermediate state,... University Of Washington

Distributed control adaptive wireless power transfer system

A wireless power transfer system (100) includes a transmitter (110) configured to transmit power to a receiver (120), for example, through coupled resonators (111,121). The transmitter receives feedback from the receiver, and uses the feedback to control the power transmission, to control a parameter at the receiver, for example, a... University Of Washington

Wnt signaling agonist molecules

Wnt signaling agonist compositions and methods for their use are provided. Wnt signaling agonists of the invention comprise a frizzled binding moiety, which is fused or conjugated to an LRP5 or LRP6 binding moiety.... University Of Washington

Baffled-tube ram accelerator

A baffled ram accelerator system includes a ram accelerator tube with an inner surface and an outer surface and a plurality of baffles disposed on the inner surface. The plurality of baffles forms a sequential series of propellant chambers along the longitudinal axis of the ram accelerator tube. An accelerator... University Of Washington

Particle positioning device with periodic dielectric structure

Devices and techniques for a particle positioning device are generally described. In some examples, a fluid may be introduced to a channel formed on a first surface of a substrate. In various examples, the channel may comprise a periodic dielectric structure etched in a first surface of the substrate and... University Of Washington

Medical implant with discontinuous osseointigrative surface

A medical implant includes a base portion configured for implantation into a bone of a patient. The base portion is formed from an electrically insulating and biocompatible base material with retaining features on an outer surface of the base portion for gripping the bone in the patient and at least... University Of Washington

Ampule autoinjector systems and methods

An autoinjector is described that includes an outer body, a first trigger, an output needle, and a first compartment. The first compartment is positioned within the outer body and includes (i) a main body, (ii) a first biasing member coupled to the first trigger, and (iii) a protrusion positioned at... University Of Washington

Systems and methods for inhibiting heterotopic ossification

Systems and methods for mitigating the formation of heterotopic ossification lesions by delivering a neuromuscular inhibitor employ a delivery device to distribute injection of the neuromuscular inhibitor. A delivery device for delivering the neuromuscular inhibitor can include an injector body, a device body for spacing the injector body from a... University Of Washington

Systems and methods for quantitative assessment of microvasculature using optical coherence tomography angiography

A five-index quantitative analysis of OCT angiograms is disclosed. One method of analyzing an anatomical region of interest of a subject includes acquiring vascular image data from the region of interest and generating a binary vasculature map from the vascular image data. A vessel skeleton map and vessel perimeter map... University Of Washington

Cancer vaccine compositions and methods of use thereof

The present application describes compositions that include an epitope of a peptide that elicits an immune response in a subject following administration. The compositions described herein include nucleic acids. The present application also describes compositions that include peptides. Also described herein are methods that include administering a composition comprising an... University Of Washington

Phone adapter for flexible laryngoscope and rigid endoscopes

An adapter for endoscopy can operably connect camera features and light source features of a portable electronic device with a respective viewfinder and illumination element of a medical endoscope. Systems including an endoscope, adapter, and handheld electronic device with a microphone, light source, and camera can, when connected, be used... University Of Washington

09/28/17 / #20170275279

Specific inhibitors of methionyl-trna synthetase

The present disclosure is generally directed to compositions useful in the inhibition of MetRS and methods for treating diseases that are ameliorated by the inhibition of MetRS.... University Of Washington

09/28/17 / #20170276578

Expansion microscopy methods and kits

Methods and kits useful in expansion microscopy are described. In particular, the present disclosure relates to methods and kits for expanding or enlarging fixed samples of interest for microscopy by synthesizing a water-swellable compound within a fixed sample, which can be physically expanded, resulting in physical magnification of the sample.... University Of Washington

09/21/17 / #20170266350

Functionalized zwitterionic and mixed charge polymers, related hydrogels, and methods for their use

Functionalized zwitterionic and mixed charge polymers and copolymers, methods for making the polymers and copolymers, hydrogels prepared from the functionalized zwitterionic and mixed charge polymers and copolymers, methods for making and using the hydrogels, and zwitterionic and mixed charge polymers and copolymers for administration for therapeutic agents.... University Of Washington

09/14/17 / #20170260328

Methods for solid freeform fabrication

The present invention provides methods, processes, and systems for the manufacture of three-dimensional articles of polymer materials using 3D printing. A syringe or an inkjet print head prints a solution of prepolymer onto a build plate. The printed prepolymer is exposed to a stimulus whereby the prepolymer is converted to... University Of Washington

09/07/17 / #20170254887

Systems and methods for measuring pressure distributions of acoustic beams from ultrasound sources

The present technology relates generally to receiving arrays to measure a characteristic of an acoustic beam and associated systems and methods. The receiving arrays can include elongated elements having at least one dimension, such as a length, that is larger than a width of an emitted acoustic beam and another... University Of Washington

08/31/17 / #20170245874

Broadly focused ultrasonic propulsion probes, systems, and methods

Disclosed herein are ultrasonic probes and systems incorporating the probes. The probes are configured to produce an ultrasonic therapy exposure that, when applied to a kidney stone, will exert an acoustic radiation force sufficient to produce ultrasonic propulsion. Unlike previous probes configured to produce ultrasonic propulsion, however, the disclosed probes... University Of Washington

08/31/17 / #20170246311

Peptides for binding alternatively activated macrophages

M2 macrophage-binding peptides and polymers and related methods of use are described.... University Of Washington

08/31/17 / #20170246805

Methods for solid freeform fabrication

The present invention provides high performance polymer (HPP) compositions, methods, processes, and systems for the manufacture of three-dimensional articles made of polymers using molding or 3D printing. The HPP compositions comprise a first HPP dissolved in a solvent and a second HPP present as a solid.... University Of Washington

08/31/17 / #20170247687

Error detection in sequence tag directed subassemblies of short sequencing reads

The invention provides methods for preparing DNA sequencing libraries by assembling short read sequencing data into longer contiguous sequences for genome assembly, full length cDNA sequencing, metagenomics, and the analysis of repetitive sequences of assembled genomes.... University Of Washington

08/31/17 / #20170248551

Inspection of structures

A method of detecting inconsistencies in a structure is presented. A pulsed laser beam is directed towards the structure. A plurality of types of ultrasonic signals is formed in the structure when radiation of the pulsed laser beam is absorbed by the structure. The plurality of types of ultrasonic signals... University Of Washington

08/31/17 / #20170249932

Confinement or movement of an object using focused ultrasound waves to generate anultrasound intensity well

A method includes transmitting a focused ultrasound wave into a medium to form (i) an ultrasound intensity well within the medium that exhibits a first range of acoustic pressure and (ii) a surrounding region of the medium that surrounds the ultrasound intensity well and exhibits a second range of acoustic... University Of Washington

08/24/17 / #20170239360

Micellic assemblies

Provided herein are micellic assemblies comprising a plurality of copolymers. In certain instauces, micellic assemblies provided herein are pH sensitive particles.... University Of Washington

08/24/17 / #20170240695

Metathesis polymerization methods

The present disclosure is directed to methods of making a polymer, including exposing a reaction mixture including a strained cyclic unsaturated monomer and an organic initiator to a stimulus to provide an activated organic initiator, whereby the activated organic initiator is effective to polymerize the strained cyclic unsaturated monomer via... University Of Washington

08/24/17 / #20170240861

Human pluripotent stem cell derived endocardial endothelium

Provided herein are methods that enable the polarization of hPSC mesoderm such that closely related yet distinct cardiovascular populations can be generated efficiently without the need of post-facto enrichment.... University Of Washington

08/17/17 / #20170233426

Method for 2-sulfation of glycosides

Method for selective 2-sulfation of glycosides.... University Of Washington

08/17/17 / #20170233722

Combinatorial photo-controlled spatial sequencing and labeling

Methods of labeling or barcoding molecules within one or more portions of a plurality of cells are provided. Kits and systems for labeling or barcoding molecules within one or more portions of a plurality of cells are also provided. The methods, kits, and systems may utilize photo-controlled adapter sequences, nucleic... University Of Washington

08/17/17 / #20170234990

Pet detector scintillator arrangement with light sharing and depth of interaction estimation

A photon detector includes a sensor array of optical sensors disposed in a plane and four substantially identical scintillation crystal bars. Each optical sensor is configured to sense luminescence. Each of the four scintillator crystal bars being a rectangular prism with four side surfaces and first and second end surfaces,... University Of Washington

08/10/17 / #20170225395

Three-dimensional printed mechanoresponsive materials and related methods

The present disclosure provides additive manufacturing methods that include depositing onto a substrate a material including a blend of a mechanochromic molecule and a matrix polymer; and fusing the material to provide an article. The mechanochromic molecule has a first end and a second end and includes at least one... University Of Washington

08/10/17 / #20170227494

Analyte sequencing with nanopores

Provided herein are methods and systems pertaining to sequencing units of analytes using nanopores. In general, arresting constructs are used to modify an analyte such that the modified analyte pauses in the opening of a nanopore. During such a pause, an ion current level is obtained that corresponds to a... University Of Washington

08/03/17 / #20170215728

Applanation tonometer

Intraocular pressure measurement devices and techniques for use therewith are generally described. In some examples the pressure measurement device may include a sleeve comprising a lower end including a first opening and an upper end. In various examples, a fastener may be used to secure the upper end of the... University Of Washington

08/03/17 / #20170218029

Polypeptides for use in self-assembling protein nanostructures

Synthetic nanostructures, polypeptides that are useful, for example, in making synthetic nanostructures, and methods for using such synthetic nanostructures are disclosed herein.... University Of Washington

08/03/17 / #20170218443

Msp nanopores and related methods

Provided herein are Mycobacterium smegmatis porin nanopores, systems that comprise these nanopores, and methods of using and making these nanopores. Such nanopores may be wild-type MspA porins, mutant MspA porins, wild-type MspA paralog porins, wild-type MspA homolog porins, mutant MspA paralog porins, mutant MspA homolog porins, or single-chain Msp porins.... University Of Washington

07/27/17 / #20170209056

Implantable self-calibrating sensor assemblies and associated methods

Self-calibrating sensor assemblies for excess body fluid drainage systems are disclosed herein. Self-calibrating sensor assemblies can include a sensor assembly engaged with a flexible interface member of a drainage catheter. The assembly includes a sensor having a body and a shaft extending from the body. A contact member is slidably... University Of Washington

07/27/17 / #20170211143

Methods of determining tissues and/or cell types giving rise to cell-free dna, and methods of identifying a disease or disorder using same

The present disclosure provides methods of determining one or more tissues and/or cell-types contributing to cell-free DNA (“cfDNA”) in a biological sample of a subject. In some embodiments, the present disclosure provides a method of identifying a disease or disorder in a subject as a function of one or more... University Of Washington

07/20/17 / #20170202874

Polymers for thermally-regulated release of hno and other molecules

Multivalent scaffolds configured to facilitate drug release upon exposure to a stimulus, such as heat, or light, are described herein. The multivalent scaffolds are covalently bound to a moiety that is susceptible to decomposition upon exposure to stimulus. The moiety releases HNO upon decomposition. In some embodiments, the moiety is... University Of Washington

07/20/17 / #20170202950

Highly immunogenic hiv p24 sequences

The invention relates to peptides comprising part or all of a conserved element within a Center-of-Tree (COT) sequence derived from a family of polypeptides encoded by naturally occurring variants of HIV. The invention also relates to immunogenic compositions and vaccines comprising said peptides. The invention also relates to methods for... University Of Washington

07/20/17 / #20170205318

Ultrasound system for shearing cellular material

A system for processing biological or other samples includes an array of transducer elements that are positioned to align with sample wells in a microplate. Each transducer element produces ultrasound energy that is focused towards a well of the microplate with sufficient acoustic pressure to cause inertial cavitation. In one... University Of Washington

07/20/17 / #20170205421

Synthetic yeast agglutination

The present invention provides methods and compositions that can be applied to screening protein-protein interaction networks, screening drug candidates that modulate protein-protein interactions for on- and off-target effects, detecting extracellular targets for which no native S. cerevisiae receptor exists, and re-engineering yeast agglutination in order to answer biological questions about... University Of Washington

07/20/17 / #20170208597

Power transmission using wireless communication signals

Examples described herein include wireless transmitters configured for power transmission. Example wireless transmitters may insert power packets into wireless communications such that power harvesting circuitry may harvest sufficiently continuous power from the wireless communication signals. Example power harvesting circuitry is configured to harvest power across multiple wireless communication channels. Example... University Of Washington

07/13/17 / #20170196292

Layered materials and structures for enhanced impact absorption

A garment worn by a wearer has an exterior shell and an interior shell with various impact absorbing material between the exterior shell and the interior shell. The impact absorbing material includes multiple structures, such as rods or filaments, capable of deforming when force is applied then returning to its... University Of Washington

Patent Packs
07/13/17 / #20170198363

Compositions and methods for detection of small molecules

Compositions and methods are provided for the detection of small molecules in a cell using biosensor molecules comprising conditionally active ligand binding domains. Compositions for conditionally activating transcription based on the presence of a small molecules in a cell are further provided, together with methods of designing, producing, and expressing... University Of Washington

07/13/17 / #20170199149

Nanopore-based analysis of protein characteristics

Methods for nanopore-based protein analysis are provided. The methods address the characterization of a target protein analyte, which has a dimension greater than an internal diameter of the nanopore tunnel, and which is also physically associated with a polymer. The methods further comprise applying an electrical potential to the nanopore... University Of Washington

07/13/17 / #20170200033

Systems and methods for enabling user interactions with wireless tags

There is provided a system including a wireless tag reader, a first wireless antenna, a wireless tag including an integrated circuit (IC), a conductive element electronically connecting the wireless tag to the first wireless antenna, a non-transitory memory storing an executable code, a hardware processor executing the executable code to... University Of Washington

06/29/17 / #20170184520

X-ray spectrometer with source entrance slit

An example spectrometer includes a crystal analyzer having a radius of curvature that defines a Rowland circle and a sample stage configured to support a sample such that the sample is offset from the Rowland circle. The spectrometer further includes an x-ray source aligned to emit x-rays toward the sample... University Of Washington

06/29/17 / #20170184543

Isotachophoretic device and methods

The present disclosure relates to devices and methods for performing isotachophoretic concentration of analytes using a porous matrix, for example, for use in diagnostic assays such as lateral flow assays. For example, the disclosure provides a method of concentrating an analyte in a sample. The method includes providing a device... University Of Washington

06/22/17 / #20170173185

Globin gene therapy for treating hemoglobinopathies

The presently disclosed subject matter provides for expression cassettes that allow for expression of a globin gene or a functional portion thereof, vectors comprising thereof, and cells transduced with such expression cassettes and vectors. The presently disclosed subject matter further provides methods for treating a hemoglobinopathy in a subject comprising... University Of Washington

06/22/17 / #20170173190

Gadolinium expressed lipid nanoparticles for magnetic resonance imaging

Lipid nanoparticles expressing metal ions and methods for using the compositions for magnetic resonance imaging.... University Of Washington

06/22/17 / #20170174907

Marine coatings

Marine coatings including cationic polymers hydrolyzable to nonfouling zwitterionic polymers, coated marine surfaces, and methods for making and using the marine coatings.... University Of Washington

06/22/17 / #20170175136

Genomic insulator elements and uses thereof

Provided herein are methods for identifying high potency genomic insulator elements that can be used in a vector composition e.g., that are useful for preventing unwanted expression of neighboring genes, such as proto-oncogenes, when administered to a subject in need thereof. Also provided herein are methods for treating disease and... University Of Washington

06/22/17 / #20170176322

Composite inspection

A method of detecting local material changes in a composite structure is presented. A pulsed laser beam is directed towards the composite structure comprised of a number of composite materials. Wide-band ultrasonic signals are formed in the composite structure when radiation of the pulsed laser beam is absorbed by the... University Of Washington

06/22/17 / #20170176393

Composite inspection

A method of detecting material changes in a composite structure is presented. A pulsed laser beam is directed towards the composite structure comprised of a number of composite materials. Wide-band ultrasonic signals are formed in the composite structure when radiation of the pulsed laser beam is absorbed by the composite... University Of Washington

06/22/17 / #20170180075

Wireless networking communication methods, systems, and devices operable using harvested power

Example devices described herein include endpoint devices which may communicate with an access point device by modulating a channel associated with the wireless communication to encode transmit data. The channel modulation may be performed by utilizing a switch to control an impedance of an antenna at the endpoint device to... University Of Washington

06/22/17 / #20170180178

Apparatuses, systems, and methods for communicating using mimo and spread spectrum coding in backscatter of ambient signals

Apparatuses, systems, ambient RF backscatter transceivers, and methods for communicating using MIMO and spread spectrum coding of backscattered ambient RF signals are described. An example system may include an ambient RF backscatter transceiver that include an antenna configured to receive a backscattered ambient radio frequency (RF) signal, and a receiver... University Of Washington

06/15/17 / #20170166875

Methods relating to nucleic acid sequence editing

The technology described herein is directed to engineered endonucleases whose activity is restricted to certain phases of the cell cycle. Provided herein are compositions and methods relating to such engineered endonucleases.... University Of Washington

06/08/17 / #20170159103

Methods and compositions for assaying the activity of one or more lysosomal enzymes

Methods and liquid compositions for assaying the activity of one or more lysosomal enzymes in a sample are provided. In some embodiments, the assay is a multiplexed assay for the activities of a plurality of lysosomal enzymes in the sample. The compositions and methods can comprise or employ: one or... University Of Washington

Patent Packs
06/08/17 / #20170162177

Methods and systems for providing presentation security for augmented reality applications

In some embodiments, an augmented reality system is provided that provides output security. In some embodiments, an operating system of the augmented reality system provides trusted management support for presenting virtual objects from untrusted applications executing in multiple isolated processes. With the output security mechanisms enabled, untrusted applications are still... University Of Washington

05/25/17 / #20170143853

Mri signal supression agents, compositions, and methods

To solve the problem of differentiating veins from lymphatics in MRI images, among other uses, the disclosed embodiments relate to compositions, kits, systems, and methods that include an MRI contrast agent and an MRI suppression agent that is also a blood pool agent. Using appropriate MRI techniques, the MRI suppression... University Of Washington

05/25/17 / #20170145141

Omega-functionalized polymers, junction-functionalized block copolymers, polymer bioconjugates, and radical chain extension polymerization

Polymeric compounds having spatially controlled bioconjugation sites are described. Functionalization is achieved by selective ω-terminal chain extension of polymer chains by radical polymerization, such as reversible addition-fragmentation chain transfer (RAFT) polymerization.... University Of Washington

05/25/17 / #20170146244

Continuous rotating detonation engines and associated systems and methods

Continuous rotating detonation engines including an annular combustion chamber formed between substantially concentric inner and outer cylindrical shells. A plurality of ignition devices extend into the annular combustion chamber and can be positioned around a circumference of at least one of the inner and outer cylindrical shells. Each ignition device... University Of Washington

05/18/17 / #20170137684

Crystals for cooling solutions and related methods

The present disclosure relates crystals capable of cooling upon illumination. In certain embodiments, the crystals include yttrium-fluoride doped with a trivalent rare earth ion. Exemplary crystals include yttrium-lithium-fluoride crystals and yttrium-sodium-fluoride crystals, doped with Yb3+, Er3+, or a combination of both. Methods of producing the crystals hydrothermally and methods of... University Of Washington

05/18/17 / #20170141793

Error correction for nucleotide data stores

This disclosure provides techniques for adding error correction to information in a data store that encodes information as a sequence of bases in polynucleotides. Errors may be introduced through creation of the database (e.g., oligonucleotide synthesis) and/or reading information from the database (e.g., polynucleotide sequencing). Additional polynucleotides added to the... University Of Washington

05/11/17 / #20170131211

Systems for cell lysis and analyte detection and associated methods

The present technology relates generally to systems for disrupting biological samples and associated devices and methods. In some embodiments, the system includes a vessel configured to receive a biological sample and a cap assembly that includes a porous membrane having a receiving region and a detection region. When the cap... University Of Washington

05/11/17 / #20170131395

Devices, systems, and methods for detecting gestures using multiple antennas and/or reflections of signals transmitted by the detecting device

Examples described herein may detect gestures using multiple antennas and/or using reflected signals transmitted by the device which is also detecting the gesture. Multiple antenna detection may allow for classification of 3D gestures around a device. The use of reflected signals transmitted by the device itself may reduce a need... University Of Washington

05/04/17 / #20170126282

Sensor devices and systems for powering same including examples of body-area networks powered by near-field communication devices

Example systems described herein may include one or more sensor devices that may be powered by a power device. The power may be transmitted from the power device to the sensor devices through a waveguide (e.g. a body). In some examples, the power device may be implemented using a near-field... University Of Washington

04/27/17 / #20170112879

Methods of protection against ischemia reperfusion injury

Provided herein are methods of treatment and prevention of ischemia reperfusion (IR) injury comprising administering a mesenchymal stem cell conditioned medium to a transplant tissue or donor.... University Of Washington

04/27/17 / #20170113045

Real-time seizure prediction informed by hidden markov model event states

Provided is an implantable medical device for predicting and treating electrical disturbances in tissue. The medical device includes an implantable telemetry unit (ITU), and an implantable leads assembly including a first and a second electrode implanted in the tissue. A processor of the ITU is configured to perform training by... University Of Washington

04/27/17 / #20170113056

Sensory input through non-invasive brain stimulation

Systems, methods and techniques for providing sensory input to a subject through non-invasive brain stimulation are generally described. In some examples, an input signal related to an environment may be received. In various further examples, a communication to the subject may be determined in response to the input signal. In... University Of Washington

04/27/17 / #20170115110

Compact portable double differential fiber optic sagnac interferometer

A compact and portable apparatus for measuring properties of objects utilizing a fiber optic Sagnac interferometer is enabled. The fiber optic Sagnac interferometer may be a double differential Sagnac interferometer. The interferometer core may be implemented with fiber optic components including polarization maintaining optical fiber, and by utilizing an auto-balanced... University Of Washington

04/20/17 / #20170106537

Haptic virtual fixture tools

Apparatus and methods for defining and utilizing virtual fixtures for haptic navigation within real-world environments, including underwater environments, are provided. A computing device can determine a real-world object within a real-world environment. The computing device can receive an indication of the real-world object. The computing device can determine a virtual... University Of Washington

04/20/17 / #20170108414

High-resolution three-dimensional imaging of mammalian hearts

Methods and materials for high-resolution three-dimensional imaging of mammalian tissues, such as heart and intestine, are described. Both methods of tissue preparation for imaging and methods of imaging are described, as well as kits comprising materials and media for use in the methods.... University Of Washington

04/20/17 / #20170108492

Dual-functional nonfouling surfaces comprising target binding partner covalently coupled to polymer attached to substrate

Dual-functional nonfouling surfaces and materials, methods for making dual-functional nonfouling surfaces and materials, and devices that include dual-functional nonfouling surfaces and materials. The dual-functional surfaces are nonfouling surfaces that resist non-specific protein adsorption and cell adhesion. The dual-functional surfaces and materials include covalently coupled biomolecules (e.g., target binding partners) that... University Of Washington

04/13/17 / #20170100145

Histotripsy treatment of hematoma

Methods for treating an extravascular hematoma in a patient can include liquefying a first portion of the extravascular hematoma by applying a first series of focused acoustic pulses to the extravascular hematoma at a first frequency; and liquefying a second portion of the extravascular hematoma by applying a second series... University Of Washington

04/06/17 / #20170095214

Apparatuses and methods for determining whether cardiopulmonary resuscitation is conducted based on an impedance signal

Examples of systems, apparatuses, and methods for determining whether CPR is being conducted based on an impedance signal are described. An example system may include a defibrillator including a cardiopulmonary resuscitation (CPR) analyzer configured to detect an impedance signal between electrodes applied to a chest of a patient. The CPR... University Of Washington

04/06/17 / #20170096517

Diblock copolymers and polynucleotide complexes thereof for delivery into cells

Described herein are copolymers, and methods of making and utilizing such copolymers. Such copolymers have at least two blocks: a first block that has at least one unit that is hydrophilic at physiologic pH, and a second block that has hydrophobic groups. This second block further has at least one... University Of Washington

04/06/17 / #20170097355

Biomarkers and methods to distinguish ovarian cancer from benign tumors

Methods for detecting and measuring metabolic changes useful in the detection of cancer, and in differentiating between ovarian cancer and benign ovarian tumor are described, as well as the unexpected and valuable combination of detecting both lipidomic and aqueous metabolites. Two independent LC-MS-based metabolomics platforms, including a global lipidomics approach,... University Of Washington

03/23/17 / #20170079622

Real-time photoacoustic and ultrasound imaging system and method

Methods and system for producing combined photoacoustic/ultrasonic image frames use a low-power narrow beam laser to direct sequential pulses along a path overlying an internal region of interest. Photoacoustic responses are received and used to generate sub-frames. Between each of the laser pulses a plurality of ultrasound pulse-echo beams are... University Of Washington

03/23/17 / #20170081686

Modified methanotrophic bacteria and uses thereof

Described herein are compositions and methods relating to the bacterial production of industrially-useful carbon products from methane. In particular, the engineered bacteria described herein have been modified to increase the production sucrose. Aerobic methanotrophic bacteria (methanotrophs or MB) are a highly specialized group of microbes utilizing methane (e.g., CH4) as... University Of Washington

03/23/17 / #20170082624

Porous membrane-binding peptides

The present invention provides porous membrane-binding polypeptides, fusion proteins thereof, and methods for use of the polypeptides and fusion proteins in binding assays.... University Of Washington








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