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Vib Vzw
Vib Vzw_20131212

Vib Vzw patents


Recent patent applications related to Vib Vzw. Vib Vzw is listed as an Agent/Assignee. Note: Vib Vzw may have other listings under different names/spellings. We're not affiliated with Vib Vzw, we're just tracking patents.

ARCHIVE: New 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 | Company Directory "V" | Vib Vzw-related inventors


Protein binding domains stabilizing functional conformational states of gpcrs and uses thereof

The present invention relates to the field of GPCR structure biology and signaling. In particular, the present invention relates to protein binding domains directed against or capable of specifically binding to a functional conformational state of a G-protein-coupled receptor (GPCR). More specifically, the present invention provides protein binding domains that... Vib Vzw

Protein binding domains stabilizing functional conformational states of gpcrs and uses thereof

The present invention relates to the field of GPCR structure biology and signaling. In particular, the present invention relates to protein binding domains directed against or capable of specifically binding to a functional conformational state of a G-protein-coupled receptor (GPCR). More specifically, the present invention provides protein binding domains that... Vib Vzw

Targeting of cytokine antagonists

The present invention relates to a fusion protein, comprising a cytokine antagonist and a targeting moiety, preferably an antibody or anti-body like molecule. In a preferred embodiment, the cytokine antagonist is a modified cytokine which binds to the receptor, but doesn't induce the receptor signalling. The invention relates further to... Vib Vzw

Markers for determining tumor hypoxia

The present application relates to the field of cancer, particular to hypoxic tumors. It was found that hypoxia is an important driver for hypermethylation of (promoters of) tumor suppressor genes. As this hypermethylation is a stable signature that is also present in circulating tumor DNA in peripheral blood, detecting this... Vib Vzw

Virus-like particle (vlp) based small molecule-protein interaction trap

This disclosure relates to a virus-like particle in which a small molecule-protein complex is entrapped, ensuring the formation of the small molecule-protein complex under physiological conditions, while protecting the small molecule-protein complex during purification and identification. The disclosure further relates to the use of such virus-like particle for the isolation... Vib Vzw

Targeted human-interferon fusion proteins

This disclosure relates to a modified α-helical bundle cytokine, with reduced activity via an α-helical bundle cytokine receptor, wherein the α-helical bundle cytokine is specifically delivered to target cells. Preferably, the α-helical bundle cytokine is a mutant, more preferably it is a mutant interferon, with low affinity to the interferon... Vib Vzw

Causative genes conferring acetic acid tolerance in yeast

The present invention relates to genes conferring acetic acid tolerance in yeast. More specifically, the invention relates to the use of DOT5, preferably in combination with CUP2 and/or HAA1 to obtain acid tolerance in yeast. Even more preferably, the invention relates to specific alleles of said genes, and to yeast... Vib Vzw

Means and methods for treatment of early-onset parkinson's disease

This application relates to the field of neurodegenerative diseases, more particularly to the field of Parkinson's disease. In particular, the disclosure describes that inhibitors reducing FAS activity can be used for treatment of Parkinson's disease, in particular, the treatment of patients suffering from Parkinson's disease having loss of function mutations... Vib Vzw

3,4-diaminobenzenesulfonamide derivatives for inhibiting cell death

This disclosure relates to a novel class of compounds having the structure of formula I as defined herein and pharmaceutical compositions comprising a compound of formula I or a pharmaceutically acceptable salt thereof. This disclosure also comprises methods of treating a subject by administering a therapeutically effective amount of a... Vib Vzw

Direct and selective inhibition of mdm4 for treatment of cancer

The present application relates to the field of cancer, particularly that of cancers with high MDM4 protein levels (such as melanoma, breast, colon or lung cancers, glioblastoma, retinoblastoma, etc.). It is shown herein that direct and selective inhibition of MDM4, e.g., by antisense RNA, leads to growth inhibition of cancer... Vib Vzw

Functional mutant alleles of ein5 for yield increase

This disclosure relates to novel mutant alleles for increasing biomass in plants and provides mutant plants comprising alleles and chimeric genes encoding the novel alleles.... Vib Vzw

A treating joint disease

The invention relates to a method for treating joint inflammation. More particularly, the invention relates to a method for treating joint disease involving the inhibition or inactivation of growth differentiation factor 15 (GDF15) in an individual.... Vib Vzw

Mutant csgg pores

The invention relates to mutant forms of the outer membrane located lipoprotein CsgG, in particular, modifications at one or more of positions Tyr51; Asn55; and Phe56. The invention also relates to analyte detection and characterisation using said mutant CsgG.... Vib Vzw

Muscle-specific nucleic acid regulatory elements and methods and use thereof

The present invention relates to nucleic acid regulatory elements that are able to enhance muscle-specific expression of genes, in particular expression in cardiac muscle and/or skeletal muscle, methods employing these regulatory elements and uses of these elements. Expression cassettes and vectors containing these nucleic acid regulatory elements are also disclosed.... Vib Vzw

Biological sampling and storage container

The invention relates to a biological sampling and storage container comprising a top cover and a bottom cover adapted to fit onto each other; and a sampling element having a proximal end onto which the top cover fits and a distal end onto which the bottom cover fits, said sampling... Vib Vzw

Binding domains directed against gpcr:g protein complexes and uses derived thereof

The present disclosure relates to the field of G protein coupled receptor (GPCR) structural biology and signaling. In particular, the present disclosure relates to binding domains directed against and/or specifically binding to GPCR:G protein complexes. Also provided are nucleic acid sequences encoding such binding domains and cells expressing or capable... Vib Vzw

Genetically modified plants having altered lignin content

The invention relates to methods for producing a plant with altered lignin content by genetically manipulating expression of a PIRIN gene. The said method comprises (a) altering expression of a gene encoding a PIRIN2 polypeptide in the plant; and/or (b) altering expression of a gene encoding a PIRIN4 polypeptide in... Vib Vzw

Hydrolysis of mannose-1-phospho-6-mannose linkage to phospho-6-mannose

Described herein are methods and genetically engineered cells useful for uncapping a mannose-6-phosphate residue on an oligosaccharide.... Vib Vzw

Liver-specific nucleic acid regulatory elements and methods and use thereof

Described are nucleic acid regulatory elements that are able to enhance liver-specific expression of genes, methods employing these regulatory elements and uses of these elements. Expression cassettes and vectors containing these nucleic acid regulatory elements are also disclosed. These are particularly useful for applications using gene therapy.... Vib Vzw

Causative genes conferring acetic acid tolerance in yeast

The present invention relates to the use of GLO1 to modulate acetic acid tolerance in yeast. More specifically, it relates to the use of a specific GLO1 allele to confer tolerance to acetic acid, and to improve the fermentation performance of yeast in the presence of acetic acid.... Vib Vzw

Opoid receptor binding agents and uses thereof

Agents that specifically bind to an opioid receptor in a conformationally specific way can be used to induce a conformational change in the receptor. Such agents have therapeutic applications and can be used in X-ray crystallography studies of the receptor. Such agents can also be used to improve drug discovery... Vib Vzw

Means and methods to increase plant yield

This disclosure relates to plants having a decreased expression of the KIX8 and KIX9 genes that result in an increased yield, particularly an increased leaf biomass. The disclosure provides plants and chimeric genes that can be used to decrease the combined KIX8/KIX9 gene expression.... Vib Vzw

Methods to select for agents that stabilize protein complexes

The application relates to the field of structural biology. More specifically, the disclosure relates to methods for the identification and characterization of biomolecular tools allowing the selective recognition and/or stabilization of distinct conformational states of protein complexes, including transient protein-protein interactions and protein-nucleic acid complexes. Such tools can then be... Vib Vzw

Protein binding domains stabilizing functional conformational states of gpcrs and uses thereof

The present invention relates to the field of GPCR structure biology and signaling. In particular, the present invention relates to protein binding domains directed against or capable of specifically binding to a functional conformational state of a G-protein-coupled receptor (GPCR). More specifically, the present invention provides protein binding domains that... Vib Vzw

A treating bone disease

The disclosure provides compositions and methods comprising a sialoadhesin binding moiety for treating metabolic and genetic bone disease, especially for treating a bone disorder of hyper-resorption of bone and/or enhanced activation of osteoclasts.... Vib Vzw

Targeted mutant alpha-helical bundle cytokines

This disclosure relates to a modified α-helical bundle cytokine, with reduced activity via an α-helical bundle cytokine receptor, wherein the α-helical bundle cytokine is specifically delivered to target cells. Preferably, the α-helical bundle cytokine is a mutant, more preferably it is a mutant interferon, with low affinity to the interferon... Vib Vzw

Responsiveness to angiogenesis inhibitors

The invention is concerned with a method of determining whether a patient is more suitably treated by a therapy with an angiogenesis inhibitor, such as bevacizumab, by determining the genotype of VEGFR-1 gene. The invention further relates to a pharmaceutical composition comprising an angiogenesis inhibitor, such as bevacizumab, for the... Vib Vzw

Inhibition of neat1 for treatment of solid tumors

The application relates to the field of cancer, particularly to the field of solid tumors. It was found that a particular long non-coding RNA (lncRNA), NEAT1, an essential architectural component of nuclear paraspeckles, is required for the survival of cancer, but not that of normal, non-transformed, cells. Inhibition of NEAT1... Vib Vzw

Means and methods for regulating secondary metabolite production in plants

This disclosure relates to the field of secondary metabolite production in plants. More specifically, the disclosure relates to chimeric genes and their use in the regulation of biosynthesis and/or production of secondary metabolites in plants and plant-derived cell cultures.... Vib Vzw








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